1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17681884.csml convertedTime:2009.07.01.11:07

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs andCTRPs.
Authors Schaffler A, Scholmerich J, Salzberger B.
Affiliation Department of Internal Medicine I, University of Regensburg, D-93042 Regensburg,Germany. andreas.schaeffler@klinik.uni-regensburg.de
Abstract Adipose tissue has long been regarded as a mostly resting tissue that isdedicated solely to energy storage and release. However, in recent years, thisview has changed dramatically following new insights into the metabolic andimmunological functions of preadipocytes and adipocytes. There are several linesof evidence for the involvement of adipose tissue in innate and acquired immuneresponses. First, adipocytes are potent producers of proinflammatory cytokines,such as interleukin-6 and tumor necrosis factor (TNF), and chemokines.Furthermore, adipocytes secrete high amounts of adipokines, such as leptin,adiponectin and resistin, that regulate monocyte/macrophage function, and alsosecrete molecules associated with the innate immune system, such as theC1qTNF-related protein superfamily. Finally, preadipocytes and adipocytesexpress a broad spectrum of functional Toll-like receptors and the former canconvert into macrophage-like cells. Collectively, these data clearly establishthe role of adipose tissue as a new member of the immune system.
PMID 17681884
Model Abstract

Entity

e1: e10: e11: e12:TLR9 e13:CpG oligodeoxydinucleotide e14:TLR9:CpG oligodeoxynucleotide e15:TLR2 e16:Pam3Cys e17:TLR2:Pam3cys e18:Leptin e19:TLR e2: e20:TLR4:LPS e21:IL-6 e22:IL-6 e23:CCL2 e24:CCL11 e25:CCL5 e26:TNF e27:TNF e28:Il-1beta e29:Il-1b e3: e30:CCL2 e31:CCL5 e32:CCL11 e33:Il-8 e34:IL-8 e35:Zymosan e36:TLR2 e37:Resistin e38:AdipoR1 e39:AdipoR2 e4: e40:gC1q e41:gC1q:AdipoR1 e42:gc1q:AdipoR2 e43:Adiponectin e44:AdipoR1:Adiponectin e45:AdipoR2:Adiponectin e46:AMPK e47:AMPK{active} e48:p38 MAPK e49:p38 MAPK{active} e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:ACC e64:ACC{p} e65:CTRP1 e66:CTRP1 e67:CTRP2 e7: e70:fatty acid e71:fatty acid{oxidized} e72:CTRP3 e73:ERK1 e74:ERK1{active} e75:ERK2 e76:ERK2{active} e77:AKT e78:AKT{active} e79:CTRP3 trimer e8: e80:PPAR-gamma e81:DNA e82:PPAR-gamma:DNA e83:CTRP3 e84:Troglitazone e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p5 p6 p7 p8 p9
Model Detail
168.75, 171.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
177.0, 192.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
648.0, 323.0
255.36718942597568, 426.33335861794274

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
839.5, 384.0
25.588752196836552, 39.36731107205624

TLR9

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1074.0, 413.5
60.0, 13.0

CpG oligodeoxydinucleotide

--

e13

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
870.5, 445.0
19.751370313527733, 38.22845867134401

TLR9:CpG oligodeoxynucleotide

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
334.5, 179.0
27.370826010544814, 42.10896309314587

TLR2

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
438.0, 123.5
27.047695713423227, 16.679412356610985

Pam3Cys

--

e16

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
445.5, 180.0
20.33589125191844, 39.359789519842145

TLR2:Pam3cys

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
107.0, 1058.5
25.599999999999994, 19.2

Leptin

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
375.0, 1121.0
42.820069204152254, 22.837370242214533

TLR

--

e19

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p3

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
168.75, 171.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
191.5, 740.0
24.740188555141415, 47.88423591317694

TLR4:LPS

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p4 p5 p6 p7 p8 p9 p11 p28

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
496.0, 941.0
39.49826989619377, 21.065743944636683

IL-6

--

e21

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1047.0, 870.5
25.599999999999998, 19.199999999999996

IL-6

--

e22

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p4

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
618.0, 956.0
44.688581314878896, 23.833910034602077

CCL2

--

e23

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p5

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
538.0, 998.0
52.16262975778547, 27.82006920415225

CCL11

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p6

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
690.0, 1018.0
52.16262975778547, 27.82006920415225

CCL5

--

e25

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p7

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
413.0, 996.0
46.193771626297575, 24.636678200692042

TNF

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p8

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
129.0, 915.0
14.483629560336759, 33.423760523854064

TNF

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
130.5, 857.0
18.473938418192795, 29.957737975447767

Il-1beta

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
481.0, 1052.0
46.193771626297575, 24.636678200692042

Il-1b

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p9

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
185.87518862352903, 189.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1043.0, 922.5
26.56000000000001, 19.919999999999998

CCL2

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1047.0, 977.5
26.72000000000001, 20.04

CCL5

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1048.0, 826.5
24.639999999999993, 18.479999999999993

CCL11

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
436.46712802768167, 1097.0
54.65397923875433, 29.14878892733564

Il-8

--

e33

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p10

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
119.5, 991.0
16.53793519822902, 26.818273294425435

IL-8

--

e34

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p10

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1042.0, 727.0
51.497056349873844, 29.18166526492851

Zymosan

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
608.0, 1075.0
47.85467128027682, 25.522491349480973

TLR2

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p11 p12 p13 p14

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1056.0, 1054.5
27.86878647615214, 17.185751660293825

Resistin

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
224.5, 182.0
23.509666080843587, 36.168717047451665

AdipoR1

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p17

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
184.5, 294.0
23.509666080843587, 36.168717047451665

AdipoR2

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16 p18

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
217.5567875770579, 219.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
98.0, 227.5
27.325417589052115, 16.850674179915476

gC1q

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
188.5, 221.0
22.61960096470072, 43.77987283490462

gC1q:AdipoR1

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
185.5, 355.0
21.817583863187895, 42.227581670686256

gc1q:AdipoR2

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
61.0, 403.5
22.55999999999999, 16.919999999999998

Adiponectin

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17 p18

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
189.5, 424.0
21.029160271870204, 40.701600526200394

AdipoR1:Adiponectin

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
193.5, 488.0
21.029160271870204, 40.701600526200394

AdipoR2:Adiponectin

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
529.0, 387.5
22.560000000000002, 16.919999999999995

AMPK

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
433.0, 267.5
22.560000000000002, 16.919999999999995

AMPK{active}

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
527.5, 310.0
16.880458844837996, 27.373717045683236

p38 MAPK

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23 p24 p25 p26

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
459.5, 454.0
16.880458844837996, 27.373717045683236

p38 MAPK{active}

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

p23 p24 p25 p26

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
648.0, 323.0
255.36718942597568, 426.33335861794274

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
351.0, 893.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
401.29367619468036, 903.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
357.06992643728904, 898.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
357.93705878547314, 899.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
351.0, 893.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
351.0, 893.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
361.93705878547314, 891.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
690.9158804881849, 1066.426469636829
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
614.6082338479803, 1187.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
351.0, 893.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
648.0, 323.0
255.36718942597568, 426.33335861794274

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
460.7511016961721, 1080.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
460.2586758712023, 1059.489410851356
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
481.43298634490134, 1118.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
630.0, 275.5
27.120144898369894, 16.724089353994774

ACC

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p27 p29 p30 p31

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
587.0, 362.0
25.60975609756097, 20.48780487804878

ACC{p}

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

p27 p29 p30 p31

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
533.0, 1140.0
45.83044982698962, 24.442906574394463

CTRP1

--

e65

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1045.0, 1159.5
24.96, 18.720000000000006

CTRP1

--

e66

cso30:c:Protein

cso30:i:CC_Extracellular

--

p32

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1067.0, 526.5
25.92, 19.44

CTRP2

--

e67

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
180.0, 177.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
498.0, 556.0
43.069806560134566, 24.406223717409585

fatty acid

--

e70

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
574.0, 624.0
43.069806560134566, 24.406223717409585

fatty acid{oxidized}

--

e71

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
136.0, 603.5
23.039999999999996, 17.28

CTRP3

--

e72

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p35 p36 p37 p38

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
243.0, 559.5
26.878647615214334, 16.575166029382174

ERK1

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
347.0, 607.5
26.878647615214334, 16.575166029382174

ERK1{active}

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
350.0, 647.5
28.15858321593882, 17.36445964982894

ERK2

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
354.0, 691.5
28.15858321593882, 17.36445964982894

ERK2{active}

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
424.5, 695.0
15.711410746629099, 25.47796337291205

AKT

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
332.5, 743.0
15.711410746629099, 25.47796337291205

AKT{active}

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
85.0, 721.5
38.88000000000001, 29.159999999999997

CTRP3 trimer

--

e79

cso30:c:Protein

cso30:i:CC_Extracellular

--

p38

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
183.0, 198.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
726.0, 1095.5
27.13221976252768, 16.731535520225403

PPAR-gamma

--

e80

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p39

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
546.0, 1193.5
60.0, 13.0

DNA

--

e81

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p39

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
662.0, 1227.5
60.0, 17.0

PPAR-gamma:DNA

--

e82

cso30:c:Complex

cso30:i:CC_Nucleolus

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
422.0, 1172.0
60.0, 32.0

CTRP3

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
127.0, 1214.0
15.043030869971934, 34.71468662301215

Troglitazone

--

e84

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p40

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
191.0, 219.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
897.0, 357.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m12*m13*0.1

nodelay

--

true

0

false

PMID: 17681884,16902195,17038530 Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic differentiation of mesenchymal stem cells

Go back
329.0, 989.0
21.0, 21.0

p8

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

Go back
565.0, 781.0
21.0, 21.0

p11

p11

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m36*m20*0.1

nodelay

--

true

0

false

PMID: 17681884,17090751,10823826 Stimulation with bacterial LPS, yeast cell wall zymosan or TNF of murine and human adipocytes leads to a dramatic induction of TLR2 synthesis indicating that TLR4 signaling in adipocytes induces TLR2 production.

Go back
625.0, 769.0
21.0, 21.0

p11

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m35*m36*0.1

nodelay

--

true

0

false

PMID: 17681884,17090751,10823826 Stimulation with bacterial LPS, yeast cell wall zymosan or TNF of murine and human adipocytes leads to a dramatic induction of TLR2 synthesis indicating that TLR4 signaling in adipocytes induces TLR2 production.

Go back
485.0, 741.0
21.0, 21.0

p11

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m36*m27*0.1

nodelay

--

true

0

false

PMID: 17681884,17090751,10823826 Stimulation with bacterial LPS, yeast cell wall zymosan or TNF of murine and human adipocytes leads to a dramatic induction of TLR2 synthesis indicating that TLR4 signaling in adipocytes induces TLR2 production.

Go back
705.0, 809.0
21.0, 21.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m37*m36*0.1

nodelay

--

true

0

false

PMID: 17681884,17062773 Moreover, in human adipocytes, the proinflammatory adipokine resistin induces TLR2 protein expression

Go back
101.0, 141.0
21.0, 21.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m40*m38*0.1

nodelay

--

true

0

false

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

Go back
73.0, 281.0
21.0, 21.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c44 : 1
stoichiometry:c46 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

Go back
61.0, 325.0
21.0, 21.0

p15

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m38*m43*0.1

nodelay

--

true

0

false

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

Go back
93.0, 457.0
21.0, 21.0

p15

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m39*m43*0.1

nodelay

--

true

0

false

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

Go back
278.0, 266.0
20.0, 20.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m41*m46*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
338.0, 122.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m15*m16*0.1

nodelay

--

true

0

false

PMID: 17681884,16902195,17038530 Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic differentiation of mesenchymal stem cells

Go back
270.0, 386.0
20.0, 20.0

p19

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m42*m46*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
286.0, 418.0
20.0, 20.0

p19

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m44*m46*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
322.0, 494.0
20.0, 20.0

p19

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m45*m46*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
294.0, 314.0
20.0, 20.0

p19

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m41*m48*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
262.0, 338.0
20.0, 20.0

p19

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m42*m48*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
274.0, 458.0
20.0, 20.0

p19

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m44*m48*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
326.0, 550.0
20.0, 20.0

p19

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m45*m48*0.1

nodelay

--

true

0

false

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

Go back
550.0, 266.0
19.0, 19.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m41*m63*0.1

nodelay

--

true

0

false

Go back
544.0, 1068.0
23.0, 23.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m20*m28*m27*0.1

nodelay

--

true

0

false

PMID: 17681884,16806199 CTRP-1 is expressed in preadipocytes and upregulated dramatically in rat adipose tissue on LPS stimulation and in adipose tissue of murine models with genetically determined obesity PMID: 17681884,16806199 This LPS effect was mediated by TNF and IL-1b and both of these proinflammatory mediators can induce CTRP-1 expression in adipocytes.

Go back
366.0, 358.0
19.0, 19.0

p27

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m42*m63*0.1

nodelay

--

true

0

false

Go back
368.0, 1060.0
23.0, 23.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17681884,17525261 Interestingly, leptin is capable of inducing TLR expression and responsiveness in preadipocytes and mature adipocytes, indicating that this adipokine immunomodulates adipocyte function. In this context, mature adipocytes seem to be responsive to a broader spectrum of TLR ligands than preadipocytes

Go back
326.0, 438.0
19.0, 19.0

p27

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m44*m63*0.1

nodelay

--

true

0

false

Go back
378.0, 538.0
19.0, 19.0

p27

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m45*m63*0.1

nodelay

--

true

0

false

Go back
836.0, 1224.0
23.0, 23.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17681884,16806199 CTRP-1 is expressed in preadipocytes and upregulated dramatically in rat adipose tissue on LPS stimulation and in adipose tissue of murine models with genetically determined obesity PMID: 17681884,16806199 This LPS effect was mediated by TNF and IL-1b and both of these proinflammatory mediators can induce CTRP-1 expression in adipocytes.

Go back
909.0, 617.0
21.0, 21.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m67*m46*0.1

nodelay

--

true

0

false

PMID: 17681884,15231994 CTRP-2, the mouse paralog most similar to adiponectin, enhances glycogen accumulation and fatty acid oxidation in myotubes by activating the AMPK signaling pathway

Go back
577.0, 493.0
21.0, 21.0

p34

p34

cso30:i:ME_Oxidation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c120 : 1
stoichiometry:c98 : 1

m70*m47*0.1

nodelay

--

true

0

false

PMID: 17681884,15231994 CTRP-2, the mouse paralog most similar to adiponectin, enhances glycogen accumulation and fatty acid oxidation in myotubes by activating the AMPK signaling pathway

Go back
262.0, 606.0
19.0, 19.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m72*m73*0.1

nodelay

--

true

0

false

PMID: 17681884,16650001 CTRP-3 stimulates the proliferation of mesenchymal chondroprogenitor cells through the activation of ERK1/2 and Akt

Go back
274.0, 646.0
19.0, 19.0

p35

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m72*m75*0.1

nodelay

--

true

0

false

PMID: 17681884,16650001 CTRP-3 stimulates the proliferation of mesenchymal chondroprogenitor cells through the activation of ERK1/2 and Akt

Go back
270.0, 698.0
19.0, 19.0

p35

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m72*m77*0.1

nodelay

--

true

0

false

PMID: 17681884,16650001 CTRP-3 stimulates the proliferation of mesenchymal chondroprogenitor cells through the activation of ERK1/2 and Akt

Go back
89.0, 649.0
21.0, 21.0

p38

p38

cso30:i:ME_Trimerization

cso30:i:CC_EndosomeLumen

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 17681884,17311679 CTRP-3 is a secreted protein, can be detected in human serum and forms stable trimers

Go back
637.0, 1129.0
21.0, 21.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Nucleolus

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m80*m81*0.1

nodelay

--

true

0

false

PMID: 17681884,17299102 Moreover, PPARg activation exerts anti-inflammatory effects and PPARg can bind specifically to the CTRP-3 promoter and inhibit CTRP-3 gene expression when activated by troglitazone, an exogenous PPARg activator

Go back
490.0, 866.0
19.0, 19.0

p4

p4

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m20*m21*0.1

nodelay

--

true

0

false

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11 PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

Go back
513.0, 1245.0
21.0, 21.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c115 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 17681884,17299102 Moreover, PPARg activation exerts anti-inflammatory effects and PPARg can bind specifically to the CTRP-3 promoter and inhibit CTRP-3 gene expression when activated by troglitazone, an exogenous PPARg activator

Go back
730.0, 890.0
19.0, 19.0

p4

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m23*m20*0.1

nodelay

--

true

0

false

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11 PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

Go back
662.0, 826.0
19.0, 19.0

p4

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c20 : 1

m20*m24*0.1

nodelay

--

true

0

false

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11

Go back
774.0, 926.0
19.0, 19.0

p4

p7

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c17 : 1

m25*m20*0.1

nodelay

--

true

0

false

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11

Go back
313.0, 917.0
21.0, 21.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m20*m26*0.1

nodelay

--

true

0

false

PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

Go back
401.0, 861.0
21.0, 21.0

p8

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m29*m20*0.1

nodelay

--

true

0

false

PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

Go back
865.0, 379.38925153189456

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
503.676232709847, 892.8224193126193

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
533.0, 519.52380597346

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 612.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
259.0, 576.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 616.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 616.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.0, 656.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.0, 661.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 620.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
297.0, 708.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 715.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.0, 876.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
115.65685424949238, 621.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
100.0, 670.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.4353305060856, 1109.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.0, 1154.1778465754876

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 1150.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.7868443531486, 1209.52380597346

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.9728138699361, 1240.0

c116

c116

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
142.0, 1231.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.0, 403.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.4304642766784, 288.75911012547124

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 911.5009923464537

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
449.0, 284.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
216.0, 767.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.0, 901.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.0, 766.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
573.0, 851.8163240255034

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 938.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.0, 951.5158932948676

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
216.0, 768.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.7290821472562, 373.06428902069575

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.0, 836.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.0, 781.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.4995185980357, 939.6643604056492

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
150.99778638623323, 928.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.44111761376183, 889.2220986955496

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
216.0, 770.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
157.0, 872.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.9250453320943, 1014.3752988579824

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.99828238638958, 1000.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.49689686312, 809.8587085313798

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
888.182592802198, 378.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.8789765458099, 228.46401326691455

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.0, 765.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.968935072917, 744.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0, 797.9992121816395

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
361.56725146193713, 228.16063663421818

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.0078397333506, 769.4130223349507

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.0, 760.5777087639997

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.0659261813976, 228.72864470738668

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.594652807391, 831.5288579520637

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
636.0, 837.63194973521

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 149.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.07456715133, 227.884613462592

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
112.0, 170.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
129.45739530241863, 158.89607584559946

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
122.0, 162.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
90.0, 251.19388070996638

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
101.87913857256363, 295.38534304572545

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
94.0, 299.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
88.17045664806804, 210.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
72.0, 354.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
82.0, 344.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.0, 132.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
114.0680069693155, 330.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
77.0, 420.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
114.0, 472.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 247.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
305.2228841505914, 284.43946864313875

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.0, 276.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 379.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
298.0, 396.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.0, 288.7348182818526

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 431.2639240088534

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.0, 138.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.9285756673952, 397.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 289.74190512016673

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 504.29885666707884

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.1014613972897, 402.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 291.18257043321626

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 252.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.0, 324.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
314.0, 333.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 354.7339445046936

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.96819908896055, 325.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
133.0, 1068.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
282.0, 354.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 447.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
300.9550720926676, 329.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.0, 468.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 512.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.1877316447983, 334.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 478.5566786900217

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 244.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.9615792869974, 277.7831061593768

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 285.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.0, 1083.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 368.3518604324392

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
392.63194973521007, 288.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.0, 368.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 444.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.05882352941177, 291.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0, 378.1935699018565

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 510.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
402.5629836812244, 292.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 387.1151037770579

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.0, 775.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
216.0, 769.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.0, 876.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.0, 935.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.0, 1091.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.0, 1159.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.0, 1175.4188594645682

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.9303267043271, 543.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.0, 514.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back