PMID: 17681884,16902195,17038530 Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic differentiation of mesenchymal stem cells

PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

PMID: 17681884,17090751,10823826 Stimulation with bacterial LPS, yeast cell wall zymosan or TNF of murine and human adipocytes leads to a dramatic induction of TLR2 synthesis indicating that TLR4 signaling in adipocytes induces TLR2 production.

PMID: 17681884,17090751,10823826 Stimulation with bacterial LPS, yeast cell wall zymosan or TNF of murine and human adipocytes leads to a dramatic induction of TLR2 synthesis indicating that TLR4 signaling in adipocytes induces TLR2 production.

PMID: 17681884,17090751,10823826 Stimulation with bacterial LPS, yeast cell wall zymosan or TNF of murine and human adipocytes leads to a dramatic induction of TLR2 synthesis indicating that TLR4 signaling in adipocytes induces TLR2 production.

PMID: 17681884,17062773 Moreover, in human adipocytes, the proinflammatory adipokine resistin induces TLR2 protein expression

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

PMID: 17681884 Interestingly, there is also evidence for a dichotomy of the gC1q?receptor interaction because there are two high- and low-affinity receptors for gC1q and full-length adiponectin: AdipoR1 and AdipoR2 (adiponectin receptors type 1 and type 2).

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,16902195,17038530 Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic differentiation of mesenchymal stem cells

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,12802337 These receptors can mediate both adiponectin- and gC1q-induced activation of adenosine monophosphateactivated kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) and phosphorylation of ACC (acetyl-CoA-carboxylase)

PMID: 17681884,16806199 CTRP-1 is expressed in preadipocytes and upregulated dramatically in rat adipose tissue on LPS stimulation and in adipose tissue of murine models with genetically determined obesity PMID: 17681884,16806199 This LPS effect was mediated by TNF and IL-1b and both of these proinflammatory mediators can induce CTRP-1 expression in adipocytes.

PMID: 17681884,17525261 Interestingly, leptin is capable of inducing TLR expression and responsiveness in preadipocytes and mature adipocytes, indicating that this adipokine immunomodulates adipocyte function. In this context, mature adipocytes seem to be responsive to a broader spectrum of TLR ligands than preadipocytes

PMID: 17681884,16806199 CTRP-1 is expressed in preadipocytes and upregulated dramatically in rat adipose tissue on LPS stimulation and in adipose tissue of murine models with genetically determined obesity PMID: 17681884,16806199 This LPS effect was mediated by TNF and IL-1b and both of these proinflammatory mediators can induce CTRP-1 expression in adipocytes.

PMID: 17681884,15231994 CTRP-2, the mouse paralog most similar to adiponectin, enhances glycogen accumulation and fatty acid oxidation in myotubes by activating the AMPK signaling pathway

PMID: 17681884,15231994 CTRP-2, the mouse paralog most similar to adiponectin, enhances glycogen accumulation and fatty acid oxidation in myotubes by activating the AMPK signaling pathway

PMID: 17681884,16650001 CTRP-3 stimulates the proliferation of mesenchymal chondroprogenitor cells through the activation of ERK1/2 and Akt

PMID: 17681884,16650001 CTRP-3 stimulates the proliferation of mesenchymal chondroprogenitor cells through the activation of ERK1/2 and Akt

PMID: 17681884,16650001 CTRP-3 stimulates the proliferation of mesenchymal chondroprogenitor cells through the activation of ERK1/2 and Akt

PMID: 17681884,17311679 CTRP-3 is a secreted protein, can be detected in human serum and forms stable trimers

PMID: 17681884,17299102 Moreover, PPARg activation exerts anti-inflammatory effects and PPARg can bind specifically to the CTRP-3 promoter and inhibit CTRP-3 gene expression when activated by troglitazone, an exogenous PPARg activator

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11 PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

PMID: 17681884,17299102 Moreover, PPARg activation exerts anti-inflammatory effects and PPARg can bind specifically to the CTRP-3 promoter and inhibit CTRP-3 gene expression when activated by troglitazone, an exogenous PPARg activator

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11 PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11

PMID: 17681884 Preadipocytes can react rapidly (within 4 h) to the TLR4 ligand lipopolysaccharide (LPS) by secreting proinflammatory mediators, such as IL-6 and the chemokines CCL2, CCL5 and CCL11

PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes

PMID: 17681884,16873530,17090751 The proinflammatory response capacity of adipose tissue to LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and CCL2 secretion, seems to be based mainly on preadipocytes rather than on mature adipocytes