_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e3
_enti_e4
_enti_e2
_enti_e55
_enti_e5
_enti_e53
_enti_e59
_enti_e6
_enti_e11
_enti_e56
_enti_e54
_enti_e50
_enti_e51
_enti_e52
_enti_e61
_enti_e58
_enti_e57
_enti_e60
_enti_e62
g1_fact_g1
g1_fact_g14
g2_fact_g12
g2_fact_g13
g1_fact_g2
p1_propro_p1
PMID: 17681884,16902195,17038530
Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and
Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic
differentiation of mesenchymal stem cells
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17681884,16902195,17038530
Synthetic CpG oligodeoxydinucleotide, a TLR9 ligand, can affect mesenchymal stem-cell proliferation and
Pam3Cys, a prototypic TLR2 ligand, inhibits adipogenic
differentiation of mesenchymal stem cells
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17681884,17525261
Interestingly,
leptin is capable of inducing TLR expression and
responsiveness in preadipocytes and mature adipocytes, indicating that this adipokine immunomodulates adipocyte
function. In this context, mature adipocytes seem to
be responsive to a broader spectrum of TLR ligands than
preadipocytes
c7 cso30:c:InputAssociation connector
c8 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
c9 cso30:c:InputAssociation connector
c10 cso30:c:InputAssociation connector
c11 cso30:c:OutputProcess connector
p4_propro_p5
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
c12 cso30:c:InputAssociation connector
c13 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p4_propro_p6
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
c15 cso30:c:InputAssociation connector
c16 cso30:c:InputAssociation connector
c20 cso30:c:OutputProcess connector
p4_propro_p7
PMID: 17681884
Preadipocytes can react rapidly (within 4 h) to the TLR4
ligand lipopolysaccharide (LPS) by secreting proinflammatory
mediators, such as IL-6 and the chemokines CCL2,
CCL5 and CCL11
c18 cso30:c:InputAssociation connector
c19 cso30:c:InputAssociation connector
c17 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
c21 cso30:c:InputAssociation connector
c22 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p8_propro_p9
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
c24 cso30:c:InputAssociation connector
c25 cso30:c:InputAssociation connector
c26 cso30:c:OutputProcess connector
p8_propro_p10
PMID: 17681884,16873530,17090751
The
proinflammatory response capacity of adipose tissue to
LPS, such as the induction of IL-6, TNF, IL-1b, IL-8 and
CCL2 secretion, seems to be based mainly on preadipocytes
rather than on mature adipocytes
c27 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17681884,17090751,10823826
Stimulation with bacterial LPS, yeast cell wall zymosan or
TNF of murine and human adipocytes leads to a dramatic
induction of TLR2 synthesis indicating that TLR4
signaling in adipocytes induces TLR2 production.
c29 cso30:c:InputAssociation connector
c31 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p11_propro_p12
PMID: 17681884,17090751,10823826
Stimulation with bacterial LPS, yeast cell wall zymosan or
TNF of murine and human adipocytes leads to a dramatic
induction of TLR2 synthesis indicating that TLR4
signaling in adipocytes induces TLR2 production.
c32 cso30:c:InputAssociation connector
c33 cso30:c:InputAssociation connector
c34 cso30:c:OutputProcess connector
p11_propro_p13
PMID: 17681884,17090751,10823826
Stimulation with bacterial LPS, yeast cell wall zymosan or
TNF of murine and human adipocytes leads to a dramatic
induction of TLR2 synthesis indicating that TLR4
signaling in adipocytes induces TLR2 production.
c35 cso30:c:InputAssociation connector
c36 cso30:c:InputAssociation connector
c37 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17681884,17062773
Moreover, in human adipocytes, the proinflammatory
adipokine resistin induces TLR2 protein
expression
c38 cso30:c:InputAssociation connector
c39 cso30:c:InputAssociation connector
c40 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1qreceptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
c41 cso30:c:InputProcess connector
c42 cso30:c:InputProcess connector
c43 cso30:c:OutputProcess connector
p15_propro_p16
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1qreceptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
c45 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
c46 cso30:c:OutputProcess connector
p15_propro_p17
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1qreceptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
c47 cso30:c:InputProcess connector
c48 cso30:c:InputProcess connector
c49 cso30:c:OutputProcess connector
p15_propro_p18
PMID: 17681884
Interestingly, there is also evidence for a dichotomy of the
gC1qreceptor interaction because there are two high- and
low-affinity receptors for gC1q and full-length adiponectin:
AdipoR1 and AdipoR2 (adiponectin receptors type 1 and
type 2).
c50 cso30:c:InputProcess connector
c51 cso30:c:InputProcess connector
c52 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c53 cso30:c:InputAssociation connector
c54 cso30:c:InputProcess connector
c55 cso30:c:OutputProcess connector
p19_propro_p20
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c56 cso30:c:InputAssociation connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p19_propro_p21
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c59 cso30:c:InputAssociation connector
c60 cso30:c:InputProcess connector
c61 cso30:c:OutputProcess connector
p19_propro_p22
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c62 cso30:c:InputAssociation connector
c63 cso30:c:InputProcess connector
c64 cso30:c:OutputProcess connector
p19_propro_p23
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c65 cso30:c:InputAssociation connector
c66 cso30:c:InputProcess connector
c67 cso30:c:OutputProcess connector
p19_propro_p24
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c68 cso30:c:InputAssociation connector
c69 cso30:c:InputProcess connector
c70 cso30:c:OutputProcess connector
p19_propro_p25
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c71 cso30:c:InputAssociation connector
c72 cso30:c:InputProcess connector
c73 cso30:c:OutputProcess connector
p19_propro_p26
PMID: 17681884,12802337
These receptors can mediate both adiponectin- and
gC1q-induced activation of adenosine monophosphateactivated
kinase (AMPK) and p38 mitogen-activated
protein kinase (p38 MAPK) and phosphorylation of ACC
(acetyl-CoA-carboxylase)
c74 cso30:c:InputAssociation connector
c75 cso30:c:InputProcess connector
c76 cso30:c:OutputProcess connector
p27_propro_p27
c77 cso30:c:InputAssociation connector
c78 cso30:c:InputProcess connector
c79 cso30:c:OutputProcess connector
p27_propro_p29
c80 cso30:c:InputAssociation connector
c81 cso30:c:InputProcess connector
c82 cso30:c:OutputProcess connector
p27_propro_p30
c83 cso30:c:InputAssociation connector
c84 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p27_propro_p31
c86 cso30:c:InputAssociation connector
c87 cso30:c:InputProcess connector
c88 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 17681884,16806199
CTRP-1 is expressed in preadipocytes and
upregulated dramatically in rat adipose tissue on LPS
stimulation and in adipose tissue of murine models with
genetically determined obesity
PMID: 17681884,16806199
This LPS effect was
mediated by TNF and IL-1b and both of these proinflammatory
mediators can induce CTRP-1 expression
in adipocytes.
c89 cso30:c:InputAssociation connector
c90 cso30:c:InputAssociation connector
c91 cso30:c:InputAssociation connector
c92 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 17681884,16806199
CTRP-1 is expressed in preadipocytes and
upregulated dramatically in rat adipose tissue on LPS
stimulation and in adipose tissue of murine models with
genetically determined obesity
PMID: 17681884,16806199
This LPS effect was
mediated by TNF and IL-1b and both of these proinflammatory
mediators can induce CTRP-1 expression
in adipocytes.
c93 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 17681884,15231994
CTRP-2, the mouse paralog most
similar to adiponectin, enhances glycogen accumulation
and fatty acid oxidation in myotubes by activating the
AMPK signaling pathway
c95 cso30:c:InputAssociation connector
c118 cso30:c:InputProcess connector
c119 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 17681884,15231994
CTRP-2, the mouse paralog most
similar to adiponectin, enhances glycogen accumulation
and fatty acid oxidation in myotubes by activating the
AMPK signaling pathway
c100 cso30:c:InputProcess connector
c120 cso30:c:InputAssociation connector
c98 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 17681884,16650001
CTRP-3 stimulates
the proliferation of mesenchymal chondroprogenitor cells
through the activation of ERK1/2 and Akt
c101 cso30:c:InputAssociation connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p35_propro_p36
PMID: 17681884,16650001
CTRP-3 stimulates
the proliferation of mesenchymal chondroprogenitor cells
through the activation of ERK1/2 and Akt
c104 cso30:c:InputAssociation connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p35_propro_p37
PMID: 17681884,16650001
CTRP-3 stimulates
the proliferation of mesenchymal chondroprogenitor cells
through the activation of ERK1/2 and Akt
c107 cso30:c:InputAssociation connector
c108 cso30:c:InputProcess connector
c109 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 17681884,17311679
CTRP-3 is a
secreted protein, can be detected in human serum and
forms stable trimers
c110 cso30:c:InputProcess connector
c111 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 17681884,17299102
Moreover, PPARg activation
exerts anti-inflammatory effects and PPARg can bind
specifically to the CTRP-3 promoter and inhibit CTRP-3
gene expression when activated by troglitazone, an exogenous
PPARg activator
c112 cso30:c:InputProcess connector
c113 cso30:c:InputProcess connector
c114 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 17681884,17299102
Moreover, PPARg activation
exerts anti-inflammatory effects and PPARg can bind
specifically to the CTRP-3 promoter and inhibit CTRP-3
gene expression when activated by troglitazone, an exogenous
PPARg activator
c116 cso30:c:InputInhibitor connector
c117 cso30:c:InputAssociation connector
c115 cso30:c:OutputProcess connector
TLR9_enti_e12
TLR9
CpG oligodeoxydinucleotide_enti_e13
CpG oligodeoxydinucleotide
TLR9:CpG oligodeoxynucleotide_enti_e14
TLR9:CpG oligodeoxynucleotide
TLR2_enti_e15
TLR2
Pam3Cys_enti_e16
Pam3Cys
TLR2:Pam3cys_enti_e17
TLR2:Pam3cys
Leptin_enti_e18
Leptin
TLR_enti_e19
TLR
TLR4:LPS_enti_e20
TLR4:LPS
IL-6_enti_e21
IL-6
IL-6_enti_e22
IL-6
CCL2_enti_e23
CCL2
CCL11_enti_e24
CCL11
CCL5_enti_e25
CCL5
TNF_enti_e26
TNF
TNF_enti_e27
TNF
Il-1beta_enti_e28
Il-1beta
Il-1b_enti_e29
Il-1b
CCL2_enti_e30
CCL2
CCL5_enti_e31
CCL5
CCL11_enti_e32
CCL11
Il-8_enti_e33
Il-8
IL-8_enti_e34
IL-8
TLR2_enti_e36
TLR2
Zymosan_enti_e35
Zymosan
Resistin_enti_e37
Resistin
AdipoR1_enti_e38
AdipoR1
AdipoR2_enti_e39
AdipoR2
gC1q_enti_e40
gC1q
gC1q:AdipoR1_enti_e41
gC1q:AdipoR1
gc1q:AdipoR2_enti_e42
gc1q:AdipoR2
Adiponectin_enti_e43
Adiponectin
AdipoR1:Adiponectin_enti_e44
AdipoR1:Adiponectin
AdipoR2:Adiponectin_enti_e45
AdipoR2:Adiponectin
AMPK_enti_e46
AMPK
AMPK{active}_enti_e47
AMPK{active}
p38 MAPK_enti_e48
p38 MAPK
p38 MAPK{active}_enti_e49
p38 MAPK{active}
ACC_enti_e63
ACC
ACC{p}_enti_e64
ACC{p}
CTRP1_enti_e65
CTRP1
CTRP1_enti_e66
CTRP1
CTRP2_enti_e67
CTRP2
fatty acid_enti_e70
fatty acid
fatty acid{oxidized}_enti_e71
fatty acid{oxidized}
CTRP3_enti_e72
CTRP3
ERK1_enti_e73
ERK1
ERK1{active}_enti_e74
ERK1{active}
ERK2_enti_e75
ERK2
ERK2{active}_enti_e76
ERK2{active}
AKT_enti_e77
AKT
AKT{active}_enti_e78
AKT{active}
CTRP3 trimer_enti_e79
CTRP3 trimer
PPAR-gamma_enti_e80
PPAR-gamma
DNA_enti_e81
DNA
PPAR-gamma:DNA_enti_e82
PPAR-gamma:DNA
CTRP3_enti_e83
CTRP3
Troglitazone_enti_e84
Troglitazone