_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e18
default_fact_i1
default_fact_i6
default_fact_i2
_enti_e59
_enti_e53
_enti_e16
_enti_e17
default_fact_i3
default_fact_i4
default_fact_i5
default_fact_i7
_enti_e54
_enti_e56
_enti_e50
_enti_e52
_enti_e51
default_fact_i8
_enti_e61
_enti_e58
_enti_e57
default_fact_i9
_enti_e62
_enti_e60
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g1
g3_fact_g4
g1_fact_g6
g2_fact_g5
g1_fact_g3
p1_propro_p1
PMID: 17702640, 11846986
They are expressed preferentially in hematopoietic cells, of both myeloid and lymphoid origin, and interact with the same partner transcription factors such as PU.1, an immune cell specific protein of the Ets family, although the two factors associate with distinct factors as well.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17702640, 11846986
They are expressed preferentially in hematopoietic cells, of both myeloid and lymphoid origin, and interact with the same partner transcription factors such as PU.1, an immune cell specific protein of the Ets family, although the two factors associate with distinct factors as well.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17702640, 16966383
In the past few years IRF-4 and IRF-8 first, and IRF-1 next, have emerged as key players of DC development.
PMID: 17702640, 16474425, 14670306
As STAT-3 is required for Flt3L-dependent differentiation of pDCs and CD8α+ DCs, it may be suggested that IRF-8, acting downstream of the Flt3L/STAT3 pathway, specifically regulates the differentiation of these DC subsets.
PMID: 17702640, 15829558
Moreover, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), a potent inhibitor of DC differentiation, completely abolishes in vitro-induced up-regulation of IRF-4 in monocytes-derived DCs and blood mDCs but not in pDCs.
PMID: 17702640, 16172134
Moreover, at variance with IRF-4, IRF-1 appears to function as a negative regulator of CD4+CD8α DC differentiation. In support of this finding, IRF-4 is shown to be a natural antagonist of IRF-1 in immune cells including DCs.
PMID: 17702640, 17018853, 10891453
Thus, in accordance with the reports indicating that IFNalpha/beta exert an inhibitory effect on human DC maturation [33] and [34], IRF-2 may protect developing DCs, especially myeloid lineage-related subsets, from detrimental effects of high levels of IFNalpha/beta such as maturation arrest.
c7 cso30:c:InputAssociation connector
c8 cso30:c:InputAssociation connector
c9 cso30:c:InputInhibitor connector
c55 cso30:c:InputInhibitor connector
c68 cso30:c:InputAssociation connector
c31 cso30:c:InputAssociation connector
c32 cso30:c:InputAssociation connector
c40 cso30:c:InputInhibitor connector
p5_propro_p5
PMID: 17702640
The Flt3 ligand (Flt3L) expands preferentially pDCs and CD8α+ DCs, in which IRF-8 expression is predominant.
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 17702640
The Flt3 ligand (Flt3L) expands preferentially pDCs and CD8α+ DCs, in which IRF-8 expression is predominant.
PMID: 17702640
Thus, the differentiation and functions of Flt3L-induced DC subsets depend on IRF-8 activity.
PMID: 17702640, 15728463
Whereas, GM-CSF selectively promotes the differentiation of CD8α DCs that predominantly express IRF-4.
c16 cso30:c:InputAssociation connector
c20 cso30:c:InputAssociation connector
p7_propro_p7
PMID: 17702640, 15728463
Whereas, GM-CSF selectively promotes the differentiation of CD8α DCs that predominantly express IRF-4.
c17 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17702640
IRF-8-KO DCs generated in presence of Flt3L are impaired in maturation, unlike wild type DCs that give rise to mature DCs capable of producing IL-12p40 and expressing CD8α in response to LPS.
c24 cso30:c:InputAssociation connector
c26 cso30:c:InputAssociation connector
c22 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17702640
IRF-8-KO DCs generated in presence of Flt3L are impaired in maturation, unlike wild type DCs that give rise to mature DCs capable of producing IL-12p40 and expressing CD8α in response to LPS.
c25 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17702640
IRF-8-KO DCs generated in presence of Flt3L are impaired in maturation, unlike wild type DCs that give rise to mature DCs capable of producing IL-12p40 and expressing CD8α in response to LPS.
c28 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17702640, 16474425, 14670306
As STAT-3 is required for Flt3L-dependent differentiation of pDCs and CD8α+ DCs, it may be suggested that IRF-8, acting downstream of the Flt3L/STAT3 pathway, specifically regulates the differentiation of these DC subsets.
c21 cso30:c:InputAssociation connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17702640, 16272311
Consistent with this finding, it has been reported that this growth factor specifically stimulates IRF-4 expression in human monocytes-derived DCs through the activation of NF-kappaB.
c35 cso30:c:InputProcess connector
c37 cso30:c:InputAssociation connector
c36 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17702640, 16272311
Consistent with this finding, it has been reported that this growth factor specifically stimulates IRF-4 expression in human monocytes-derived DCs through the activation of NF-kappaB.
PMID: 17702640, 15829558
Moreover, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), a potent inhibitor of DC differentiation, completely abolishes in vitro-induced up-regulation of IRF-4 in monocytes-derived DCs and blood mDCs but not in pDCs.
c38 cso30:c:InputAssociation connector
c41 cso30:c:InputInhibitor connector
c39 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17702640
Of note, the entire splenic DC population from IRF-1 KO mice fail to undergo maturation in response to viral or bacterial stimuli, such as New Castle disease (NDV) virus and LPS, and express high levels of tolerogenic cytokines such as IL-10, accounting for the induction of suppressor activity in allogeneic CD4+CD25+ regulatory T (Treg) cells.
c11 cso30:c:InputAssociation connector
c10 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17702640
In addition, IRF-1, like IRF-8 positively regulates the expression of some proinflammatory cytokines, such as IL-12p40.
c12 cso30:c:InputAssociation connector
c43 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17702640
In addition, IRF-1, like IRF-8 positively regulates the expression of some proinflammatory cytokines, such as IL-12p40.
c42 cso30:c:InputAssociation connector
c44 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17702640, 16339401
Intriguingly, IRF-8 has been shown to be required for the induction of the enzyme indoleamine 2,3-dioxygenase, an essential component of the tolerogenic program of murine CD8α+ DCs and LPS-stimulated, monocyte-derived human DCs.
c46 cso30:c:InputAssociation connector
c48 cso30:c:InputAssociation connector
c49 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17702640, 16339401
Intriguingly, IRF-8 has been shown to be required for the induction of the enzyme indoleamine 2,3-dioxygenase, an essential component of the tolerogenic program of murine CD8α+ DCs and LPS-stimulated, monocyte-derived human DCs.
c45 cso30:c:InputAssociation connector
c47 cso30:c:InputAssociation connector
c51 cso30:c:InputAssociation connector
c50 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17702640, 16597464
This finding mirrors the ability of IRF-1 and IRF-8 to form heterocomplexes and cooperatively regulate the expression of many genes involved in the onset of innate immunity.
c52 cso30:c:InputProcess connector
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17702640
Upon recognition of microbial components, TLRs trigger a cascade of signalling events leading to inflammatory responses through the production of a variety of cytokines.
c56 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c58 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 17702640, 17113765
Type I IFNs are the major cytokines that confer early protection against incoming pathogens, as they broadly elicit anti-viral and anti-microbial agents.
c60 cso30:c:InputAssociation connector
c61 cso30:c:InputAssociation connector
c59 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17702640
Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.
c74 cso30:c:InputAssociation connector
c65 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17702640
Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.
c75 cso30:c:InputAssociation connector
c66 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 17702640
Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.
c76 cso30:c:InputAssociation connector
c67 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 17702640
Upon recognition of microbial components, TLRs trigger a cascade of signalling events leading to inflammatory responses through the production of a variety of cytokines.
c72 cso30:c:InputAssociation connector
c69 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17702640
Upon recognition of microbial components, TLRs trigger a cascade of signalling events leading to inflammatory responses through the production of a variety of cytokines.
c71 cso30:c:InputAssociation connector
c73 cso30:c:InputAssociation connector
c70 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 17702640
Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.
c78 cso30:c:InputAssociation connector
c77 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 17702640
Type I IFN also stimulates DC maturation by increasing expression of the costimulatory molecules such as CD80, CD86, CD40 and the major histocompatibility complex antigens.
c79 cso30:c:InputAssociation connector
c80 cso30:c:InputAssociation connector
c81 cso30:c:InputAssociation connector
c82 cso30:c:InputAssociation connector
p29_propro_p29
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c83 cso30:c:InputProcess connector
c84 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c86 cso30:c:InputProcess connector
c87 cso30:c:InputProcess connector
c88 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 17702640
Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.
c89 cso30:c:InputProcess connector
c202 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 17702640, 15829275
TLR7/8 and TLR9 recognize viral single-stranded RNA and double-stranded CpG-rich DNA, respectively.
c92 cso30:c:InputProcess connector
c94 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 17702640, 15829275
TLR7/8 and TLR9 recognize viral single-stranded RNA and double-stranded CpG-rich DNA, respectively.
c93 cso30:c:InputProcess connector
c95 cso30:c:InputProcess connector
c96 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 17702640, 15829275
TLR7/8 and TLR9 recognize viral single-stranded RNA and double-stranded CpG-rich DNA, respectively.
c98 cso30:c:InputProcess connector
c99 cso30:c:InputProcess connector
c100 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 17702640
Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.
c101 cso30:c:InputProcess connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 17702640
Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.
c104 cso30:c:InputProcess connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 17702640
Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.
c107 cso30:c:InputProcess connector
c108 cso30:c:InputProcess connector
c109 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 17702640
Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.
c112 cso30:c:InputProcess connector
c113 cso30:c:InputProcess connector
c117 cso30:c:InputProcess connector
c120 cso30:c:InputProcess connector
c124 cso30:c:InputProcess connector
c125 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 17702640
Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.
c110 cso30:c:InputProcess connector
c111 cso30:c:InputProcess connector
c116 cso30:c:InputProcess connector
c119 cso30:c:InputProcess connector
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 17702640
Upon ligand binding, TLR7/8 and TLR9 signal through the cytoplasm adaptor MyD88 and form a signalling complex with members of the IL-1 receptor-associated kinase (IRAK1 and IRAK4), TRAF6 and IRF-7.
c114 cso30:c:InputProcess connector
c115 cso30:c:InputProcess connector
c118 cso30:c:InputProcess connector
c121 cso30:c:InputProcess connector
c126 cso30:c:InputProcess connector
c127 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c133 cso30:c:InputAssociation connector
c128 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c132 cso30:c:InputAssociation connector
c129 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c131 cso30:c:InputAssociation connector
c130 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c137 cso30:c:InputAssociation connector
c140 cso30:c:InputAssociation connector
c134 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c138 cso30:c:InputAssociation connector
c141 cso30:c:InputAssociation connector
c135 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 17702640, 15976491
Both human mDCs and mouse cDCs express TLR2, TLR3, and TLR4 and produce IL-12 upon receptor engagement.
c139 cso30:c:InputAssociation connector
c142 cso30:c:InputAssociation connector
c136 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 17702640, 11592079, 15771572
Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12.
c150 cso30:c:InputAssociation connector
c155 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 17702640, 11592079, 15771572
Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12.
c149 cso30:c:InputAssociation connector
c156 cso30:c:InputAssociation connector
c144 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 17702640, 11592079, 15771572
Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12.
PMID: 17702640, 15695821
Given the evidence that human IRF-5 selectively regulates TLR7-mediated type I IFN induction, IRF-5 may play a species-specific function.
c152 cso30:c:InputAssociation connector
c157 cso30:c:InputAssociation connector
c253 cso30:c:InputAssociation connector
c145 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 17702640, 17276695
TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.
c158 cso30:c:InputProcess connector
c172 cso30:c:InputAssociation connector
c159 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 17702640, 17276695
TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.
c160 cso30:c:InputProcess connector
c171 cso30:c:InputAssociation connector
c161 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 17702640, 17276695
TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.
c162 cso30:c:InputProcess connector
c170 cso30:c:InputAssociation connector
c163 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 17702640, 17276695
TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.
PMID: 17702640, 16243976
Lastly, a recent report shows that IRF-4 negatively regulates production of proinflammatory cytokines such as IL-6 and TNFalpha in response to TLR stimulation, suggesting that this factor prevents harmful effects of endotoxin and curtails excess inflammatory responses.
c164 cso30:c:InputAssociation connector
c318 cso30:c:InputInhibitor connector
c62 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 17702640, 17276695
TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.
PMID: 17702640, 16243976
Lastly, a recent report shows that IRF-4 negatively regulates production of proinflammatory cytokines such as IL-6 and TNFalpha in response to TLR stimulation, suggesting that this factor prevents harmful effects of endotoxin and curtails excess inflammatory responses.
c165 cso30:c:InputAssociation connector
c317 cso30:c:InputInhibitor connector
c63 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 17702640, 17276695
TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.
c166 cso30:c:InputAssociation connector
c64 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 17702640, 17276695
TRAF-6 activates a canonical IKK-mediated pathway which culminates in the induction of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-6, IL-1beta and IL-12p40.
c167 cso30:c:InputAssociation connector
c168 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 17702640, 15361868
Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.
c169 cso30:c:InputProcess connector
c175 cso30:c:OutputProcess connector
c328 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 17702640, 15361868
Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.
c173 cso30:c:InputProcess connector
c176 cso30:c:OutputProcess connector
c178 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 17702640, 15361868
Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.
c174 cso30:c:InputProcess connector
c177 cso30:c:OutputProcess connector
c179 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 17702640, 15361868
Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
c181 cso30:c:InputProcess connector
c182 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 17702640, 11592079, 15771572
Being the main TLRs expressed in the endosomal compartments of pDCs, TLR7/8 and TLR9 are involved in the recognition of viruses and bacteria and production of type I IFNs in both species although in the mouse they can also produce IL-12.
PMID: 17702640, 15361868
Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.
c147 cso30:c:InputAssociation connector
c148 cso30:c:InputAssociation connector
c151 cso30:c:InputAssociation connector
c146 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 17702640, 15361868
Alternatively, following phosphorylation by IRAK1 and activation by TRAF-dependent ubiquitination, IRF-7 dimerizes and translocates into the nucleus where together with NF-kappaB and AP-1 regulates expression of type I IFNs.
c153 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 17702640, 17113765, 16474425, 12702806
Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFNβ and IFNα4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
c183 cso30:c:InputAssociation connector
c187 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 17702640, 17113765, 16474425, 12702806
Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFNβ and IFNα4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.
PMID: 17702640
Similarly, TLR3 transmits signals through Trif to activate IRF-3, which then mediates primary IFNbeta and IFN-alpha4 induction.
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
c184 cso30:c:InputAssociation connector
c188 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 17702640, 17113765, 16474425, 12702806
Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFNβ and IFNα4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
PMID: 17702640
It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.
c185 cso30:c:InputAssociation connector
c332 cso30:c:InputAssociation connector
c189 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 17702640, 17113765, 16474425, 12702806
Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFNβ and IFNα4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.
PMID: 17702640
Similarly, TLR3 transmits signals through Trif to activate IRF-3, which then mediates primary IFNbeta and IFN-alpha4 induction.
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
PMID: 17702640
It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.
c186 cso30:c:InputAssociation connector
c330 cso30:c:InputAssociation connector
c190 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 17702640, 17113765, 16474425, 12702806
Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFNβ and IFNα4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.
c193 cso30:c:InputAssociation connector
c191 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 17702640, 17113765, 16474425, 12702806
Previous studies in non-DC cell types have shown that IFN production involves two steps, an initial induction of IFNβ and IFNα4 though IRF-3 and IRF-7 activation, leading to the second phase where additional IFNalpha genes and IRF-7 are induced in a IFN-dependent manner.
c194 cso30:c:InputAssociation connector
c192 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 17702640
Interestingly, our evidence indicates that not only IRF-3/7, IRF-8 plays a critical role in the production of type I IFNs both in pDCs and cDCs.
c34 cso30:c:InputAssociation connector
c195 cso30:c:InputAssociation connector
c197 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 17702640
Interestingly, our evidence indicates that not only IRF-3/7, IRF-8 plays a critical role in the production of type I IFNs both in pDCs and cDCs.
c33 cso30:c:InputAssociation connector
c196 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 17702640, 15711573
TLR3-mediated signalling triggers the maturation of immature CD8α+ DCs that become competent to mediate cross-priming of T cells.
c198 cso30:c:InputAssociation connector
p71_propro_p71
PMID: 17702640
Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.
c90 cso30:c:InputProcess connector
c199 cso30:c:InputProcess connector
c200 cso30:c:InputProcess connector
c201 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 17702640
Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.
c203 cso30:c:InputProcess connector
c204 cso30:c:InputProcess connector
c206 cso30:c:InputProcess connector
c205 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 17702640
Upon LPS ligation, TLR4, which forms a receptor complex with CD14 and MD-2, signals through the adaptors TIRAP and MyD88 as well as Trif and TRAM.
c207 cso30:c:InputProcess connector
c208 cso30:c:InputProcess connector
c209 cso30:c:InputProcess connector
c210 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 17702640
In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.
c214 cso30:c:InputProcess connector
c215 cso30:c:InputProcess connector
c216 cso30:c:InputProcess connector
c213 cso30:c:InputProcess connector
c217 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 17702640
In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.
c218 cso30:c:InputProcess connector
c220 cso30:c:InputAssociation connector
c219 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 17702640
The latter two molecules mediate the activation of IRF-3.
PMID: 17702640
In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.
c221 cso30:c:InputProcess connector
c211 cso30:c:InputAssociation connector
c212 cso30:c:InputAssociation connector
c222 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 17702640
In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.
c223 cso30:c:InputProcess connector
c224 cso30:c:InputProcess connector
c225 cso30:c:InputProcess connector
c226 cso30:c:OutputProcess connector
p78_propro_p78
PMID: 17702640
In particular, Trif interacts with TRAF3 and NAP1 and together cooperate to activate TBK1, which in turn mediates the phosphorylation of IRF-3.
c227 cso30:c:InputProcess connector
c229 cso30:c:InputAssociation connector
c228 cso30:c:OutputProcess connector
p79_propro_p79
PMID: 17702640
The secreted IFNs, particularly IFNb, stimulate the expression of IFN-inducible genes including IRF-7.
c231 cso30:c:InputAssociation connector
c230 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 17702640
TLR4 is expressed on the plasma membrane and is the only receptor that can mediate the induction of IFNbeta, but not IFNalpha, upon recognition of non-nucleic acid ligands such as LPS.
PMID: 17702640
It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.
c233 cso30:c:InputAssociation connector
c242 cso30:c:InputAssociation connector
c232 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 17702640, 15665823
It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.
c269 cso30:c:InputProcess connector
c235 cso30:c:OutputProcess connector
c180 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 17702640, 15665823
It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.
c234 cso30:c:InputProcess connector
c237 cso30:c:OutputProcess connector
c240 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 17702640, 15665823
It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.
c236 cso30:c:InputProcess connector
c239 cso30:c:OutputProcess connector
c329 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 17702640, 15665823
It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.
c247 cso30:c:InputAssociation connector
c243 cso30:c:OutputProcess connector
p85_propro_p85
PMID: 17702640, 15665823
It has recently been reported that another member of IRF family, namely IRF-5, participates in cytokine gene expression in response to TLR7, TLR9 and TLR4 via MyD88-dependent signalling.
c245 cso30:c:InputAssociation connector
c246 cso30:c:InputAssociation connector
c244 cso30:c:OutputProcess connector
p86_propro_p86
PMID: 17702640, 16751392
Moreover, IRF-5 is shown to be essential for TLR3 signalling, which does not utilize MyD88. A recent report indicates that IRF-5 is activated when TBK1 or IKKi/epsilon is coexpressed.
c248 cso30:c:InputProcess connector
c250 cso30:c:InputAssociation connector
c251 cso30:c:InputAssociation connector
c252 cso30:c:InputAssociation connector
c249 cso30:c:OutputProcess connector
p87_propro_p87
PMID: 17702640, 15695821
Given the evidence that human IRF-5 selectively regulates TLR7-mediated type I IFN induction, IRF-5 may play a species-specific function.
c255 cso30:c:InputAssociation connector
c256 cso30:c:InputAssociation connector
c254 cso30:c:OutputProcess connector
p88_propro_p88
PMID: 17702640, 16236719
In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.
c257 cso30:c:InputProcess connector
c258 cso30:c:InputProcess connector
c259 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 17702640, 16236719
In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.
c260 cso30:c:InputProcess connector
c261 cso30:c:InputProcess connector
c265 cso30:c:InputInhibitor connector
c262 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 17702640, 16236719
In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.
c263 cso30:c:InputProcess connector
c264 cso30:c:InputProcess connector
c266 cso30:c:InputInhibitor connector
c241 cso30:c:OutputProcess connector
p91_propro_p91
PMID: 17702640, 16236719
In this context, IRF-4 has been shown to form a complex with MyD88 to compete with IRF-5.
c238 cso30:c:InputProcess connector
c267 cso30:c:InputProcess connector
c270 cso30:c:InputInhibitor connector
c268 cso30:c:OutputProcess connector
p92_propro_p92
PMID: 17702640
It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.
c284 cso30:c:InputAssociation connector
c272 cso30:c:InputAssociation connector
c274 cso30:c:InputAssociation connector
c271 cso30:c:OutputProcess connector
p95_propro_p95
PMID: 17702640
It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.
c285 cso30:c:InputAssociation connector
c273 cso30:c:InputAssociation connector
c275 cso30:c:InputAssociation connector
c277 cso30:c:OutputProcess connector
p93_propro_p93
PMID: 17702640
In addition, pre-treatment of DCs with IFN-gamma, a strong inducer of IRF-1, leads to a robust IFNbeta induction upon CpG-B treatment.
c279 cso30:c:InputAssociation connector
c278 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 17702640
In addition, pre-treatment of DCs with IFN-gamma, a strong inducer of IRF-1, leads to a robust IFNbeta induction upon CpG-B treatment.
PMID: 17702640
It has been reported that IRF-1-KO GM-CSF-derived BM DCs are unable to induce IFNbeta, inducible nitric-oxide synthase, and IL-12p35 following CpG-A stimulation, despite that IRF-1 KO pDCs exhibit normal type I IFN gene induction upon CpG-B stimulation.
c283 cso30:c:InputAssociation connector
c286 cso30:c:InputAssociation connector
c331 cso30:c:InputAssociation connector
c281 cso30:c:OutputProcess connector
p94_propro_p94
PMID: 17702640
These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.
c288 cso30:c:InputProcess connector
c321 cso30:c:InputAssociation connector
c289 cso30:c:OutputProcess connector
p97_propro_p97
PMID: 17702640
These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.
c282 cso30:c:InputProcess connector
c326 cso30:c:InputAssociation connector
c287 cso30:c:OutputProcess connector
p98_propro_p98
PMID: 17702640
These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.
c276 cso30:c:InputProcess connector
c327 cso30:c:InputAssociation connector
c280 cso30:c:OutputProcess connector
p99_propro_p99
PMID: 17702640
These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
c293 cso30:c:InputProcess connector
c297 cso30:c:InputAssociation connector
c299 cso30:c:InputAssociation connector
c302 cso30:c:InputAssociation connector
c294 cso30:c:OutputProcess connector
p100_propro_p100
PMID: 17702640
These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
c295 cso30:c:InputProcess connector
c298 cso30:c:InputAssociation connector
c300 cso30:c:InputAssociation connector
c301 cso30:c:InputAssociation connector
c296 cso30:c:OutputProcess connector
p101_propro_p101
PMID: 17702640
These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.
c303 cso30:c:InputProcess connector
c310 cso30:c:InputAssociation connector
c304 cso30:c:OutputProcess connector
p102_propro_p102
PMID: 17702640
These properties relate to the fact that DCs express RNA helicases, RIG-1, Mda5 and LGP2, cytoplasmic proteins capable of detecting actively replicating viruses. Though the CARD domain these helicases signal to the adaptor IFNbeta promoter stimulator 1 (IPS-1), which localizes in mitochondria and mediate the activation of IRF-3 and IRF-7 through a TBK1-IKKi/epsilon-dependent pathway.
c305 cso30:c:InputProcess connector
c307 cso30:c:InputAssociation connector
c308 cso30:c:InputAssociation connector
c309 cso30:c:InputAssociation connector
c312 cso30:c:InputAssociation connector
c314 cso30:c:InputAssociation connector
c306 cso30:c:OutputProcess connector
p103_propro_p103
PMID: 17702640, 16979567
These factors, together with NF-kappaB and AP-1 activated by IPS-1 via FADD/RIP1-dependnt pathway, stimulate the expression of IFNbeta and IFNalpha genes.
c315 cso30:c:InputProcess connector
c316 cso30:c:OutputProcess connector
p104_propro_p104
PMID: 17702640
RNA helicases that recognize dsRNA also stimulate activation of IRF-3/7 leading to IFNbeta induction.
c290 cso30:c:InputProcess connector
c319 cso30:c:InputProcess connector
c320 cso30:c:OutputProcess connector
p105_propro_p105
PMID: 17702640
RNA helicases that recognize dsRNA also stimulate activation of IRF-3/7 leading to IFNbeta induction.
c291 cso30:c:InputProcess connector
c323 cso30:c:InputProcess connector
c322 cso30:c:OutputProcess connector
p106_propro_p106
PMID: 17702640
RNA helicases that recognize dsRNA also stimulate activation of IRF-3/7 leading to IFNbeta induction.
c292 cso30:c:InputProcess connector
c324 cso30:c:InputProcess connector
c325 cso30:c:OutputProcess connector
IRF-4_enti_MO000007697
IRF-4
IRF-8_enti_MO000007185
IRF-8
PU.1_enti_MO000037579
PU.1
IL-12 p40_enti_G010657
IL-12 p40
IL-12_enti_MO000017265
IL-12
IFN-beta_enti_G010228
IFN-beta
IFN-alpha_enti_e5
IFN-alpha
IFN Type I_enti_MO000016658
IFN Type I
FLT3L_enti_MO000090399
FLT3L
FLT3_enti_MO000005216
FLT3
LPS_enti_MO000016882
LPS
IRF-4: PU.1_enti_e11
IRF-4: PU.1
IRF-8: PU.1_enti_e12
IRF-8: PU.1
IRF-1_enti_MO000007685
IRF-1
NF-kappaB_enti_MO000000058
NF-kappaB
FLT3L: FLT3_enti_e14
FLT3L: FLT3
TLRs_enti_MO000019395
TLRs
TLR2_enti_MO000019397
TLR2
TLR3_enti_MO000019398
TLR3
TLR4_enti_MO000019394
TLR4
TLR8_enti_MO000042007
TLR8
TLR9_enti_MO000042012
TLR9
TLR7_enti_MO000042126
TLR7
GM-CSF_enti_MO000000099
GM-CSF
GM-CSFR_enti_MO000000090
GM-CSFR
GM-CSF: GM-CSF_enti_e15
GM-CSF: GM-CSF
CD8A_enti_G010533
CD8A
STAT3_enti_MO000013122
STAT3
STAT3 {activated}_enti_e19
STAT3 {activated}
NF-kappaB {activated}_enti_e21
NF-kappaB {activated}
IRF4_enti_G010915
IRF4
IL10_enti_G011345
IL10
INDO_enti_G010447
INDO
INDO_enti_MO000062184
INDO
IRF-1: IRF-8_enti_e13
IRF-1: IRF-8
IFNalpha, IFNbeta_enti_MO000038482
IFNalpha, IFNbeta
IRF-2_enti_MO000007690
IRF-2
ssRNA: TLR7_enti_e23
ssRNA: TLR7
ssRNA: TLR8_enti_e24
ssRNA: TLR8
CpG DNA: TLR9_enti_e25
CpG DNA: TLR9
TLR ligand_enti_e26
TLR ligand
TLR liagnd: TLRs_enti_e27
TLR liagnd: TLRs
CD80_enti_G012224
CD80
CD86_enti_G010859
CD86
CD40_enti_G010691
CD40
MyD88_enti_MO000016573
MyD88
IFN- Type I_enti_e28
IFN- Type I
IRAK-1_enti_MO000000213
IRAK-1
IRAK-4_enti_MO000039077
IRAK-4
TRAF6_enti_MO000000212
TRAF6
cytokines_enti_MO000019387
cytokines
cytokines_enti_e29
cytokines
MHC antigen_enti_e30
MHC antigen
TLR2 ligand : TLR2_enti_e31
TLR2 ligand : TLR2
TLR2 ligand_enti_e32
TLR2 ligand
TLR3 ligand_enti_e33
TLR3 ligand
TLR3 ligand: TLR3_enti_e34
TLR3 ligand: TLR3
LPS: CD14: MD-2: TLR4_enti_e35
LPS: CD14: MD-2: TLR4
ssRNA_enti_e36
ssRNA
CpG DNA_enti_e37
CpG DNA
ssRNA: TLR7: MyD88_enti_e38
ssRNA: TLR7: MyD88
ssRNA: TLR8: MyD88_enti_e39
ssRNA: TLR8: MyD88
CpG DNA: TLR9: MyD88_enti_e40
CpG DNA: TLR9: MyD88
IRF-7_enti_MO000007702
IRF-7
ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7_enti_e41
ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7
ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7_enti_e42
ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7_enti_e43
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7
IKK_enti_MO000000248
IKK
TNF-alpha_enti_G010329
TNF-alpha
IL-6_enti_G010262
IL-6
IL-1beta_enti_G010389
IL-1beta
IKK [activated}_enti_e44
IKK [activated}
IRF7: IRF-7_enti_e45
IRF7: IRF-7
IRF7: IRF-7_enti_e47
IRF7: IRF-7
AP-1_enti_MO000000276
AP-1
NF-kappaB {nucleus}_enti_e48
NF-kappaB {nucleus}
IFN-alpha4_enti_e49
IFN-alpha4
IRF-3_enti_MO000007694
IRF-3
IRF-7_enti_G010713
IRF-7
TRIF_enti_MO000041125
TRIF
MD-2_enti_MO000022131
MD-2
CD14: MD-2: TLR4_enti_e20
CD14: MD-2: TLR4
CD14_enti_MO000018132
CD14
TIRAP_enti_MO000022528
TIRAP
TRAM_enti_MO000041132
TRAM
LPS: CD14: MD-2: TLR4: MyD88: TIRAP_enti_e63
LPS: CD14: MD-2: TLR4: MyD88: TIRAP
LPS: CD14: MD-2: TLR4: TRAM: TRIF_enti_e64
LPS: CD14: MD-2: TLR4: TRAM: TRIF
NAP1_enti_e66
NAP1
TLR3 ligand: TLR3: TRIF: TRAF3: NAP1_enti_e67
TLR3 ligand: TLR3: TRIF: TRAF3: NAP1
TBK1_enti_MO000019331
TBK1
TBK1 {activated}_enti_e68
TBK1 {activated}
IRF-3{p}_enti_MO000041456
IRF-3{p}
TRAF3_enti_MO000016963
TRAF3
LPS: CD14: MD-2: TLR4: TRAM: TRIF: TRAF3: NAP1_enti_e65
LPS: CD14: MD-2: TLR4: TRAM: TRIF: TRAF3: NAP1
IRF-5_enti_MO000007700
IRF-5
IKK-i {activated}_enti_MO000016608
IKK-i {activated}
IRF-5 {activated}_enti_e69
IRF-5 {activated}
MyD88: IRF-4_enti_e70
MyD88: IRF-4
ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5_enti_e71
ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5_enti_e72
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: IRF-7: IRF-5
LPS: CD14: MD-2: TLR4: MyD88: TIRAP: IRF-5_enti_e73
LPS: CD14: MD-2: TLR4: MyD88: TIRAP: IRF-5
NOS_enti_e74
NOS
IL-12p35_enti_e77
IL-12p35
IFNgamma_enti_MO000016665
IFNgamma
IRF-1_enti_G010384
IRF-1
RIG-1_enti_e6
RIG-1
Mda-5_enti_e75
Mda-5
LGP2_enti_e76
LGP2
IPS-1_enti_e78
IPS-1
IPS-1 {activated}_enti_e79
IPS-1 {activated}
IRF-7_enti_e80
IRF-7
FADD_enti_MO000016899
FADD
RIP1_enti_MO000000065
RIP1
IKK-i_enti_e81
IKK-i
dsRNA: LGP2_enti_e82
dsRNA: LGP2
dsRNA: RIG-1_enti_e83
dsRNA: RIG-1
dsRNA: Mda-5_enti_e84
dsRNA: Mda-5
dsRNA_enti_MO000022224
dsRNA
1,25(OH)2D3_enti_e22
1,25(OH)2D3
ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6_enti_e85
ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6
ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6_enti_e86
ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6_enti_e87
CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6