1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17827709.csml convertedTime:2009.07.01.11:07

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Role of phosphoinositide 3-kinase in innate immunity.
Authors Hazeki K, Nigorikawa K, Hazeki O.
Affiliation Division of Molecular Medical Science, Graduate School of Biomedical Sciences,Hiroshima University, Hiroshima, Japan. khazeki@hiroshima-u.ac.jp
Abstract Recent advances in our understanding of the molecular basis of mammalian hostimmune responses to microbial invasion suggest that the first line of defenseagainst microbes is the recognition of pathogen-associated molecular patterns byToll-like receptors (TLRs). Phosphoinositide 3-kinase (PI3K) is thought toparticipate in the TLR signaling pathway. The activation of PI3K is commonlyobserved after stimulation with various TLR ligands. The resultant activation ofa serine-threonine protein kinase Akt leads to the phosphorylation of glycogensynthase kinase (GSK)-3beta, which is active in resting cells but is inactivatedby phosphorylation. GSK-3beta has been linked to the regulation of a multitudeof transcription factors, including NF-kappaB, AP-1, NF-AT, and CREB eithernegatively or positively. Thus, the altered activity of GSK-3beta causes diverseeffects on cytokine expression. Generally, activation of PI3K results in theinhibition of proinflammatory events such as expression of IL-12 and TNF-alpha.Thus, PI3K is a negative regulator of TLR signaling. Among the members of theClass I PI3K family, p85/p110beta appears to be the subtype activated on TLRligation, but the molecular basis for this specificity has yet to be elucidated.
PMID 17827709
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010389:IL-1beta G010453:IFN-gamma G010514:iNOS MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000041:Cot MO000000048:AKT MO000000058:NF-kappaB{active} MO000000065:RIP1 MO000000078:MEK1 MO000000104:PKC MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK MO000000248:IKK MO000000276:AP-1 MO000000289:TNF-alpha MO000000331:PIP2 MO000007384:IL-6 MO000007694:IRF-3 MO000007702:IRF-7 MO000009393:MEK2 MO000016573:MyD88 MO000016574:TAK1 MO000016597:IL-1beta MO000016599:IKK-gamma MO000016608:IKK-i MO000016625:IL-18 MO000016665:IFNgamma MO000016882:LPS MO000016941:GSK3 MO000016966:MKK3 MO000017094:IGF-1 MO000017112:SHIP MO000017190:Egr-1 MO000017257:p110alpha MO000017264:IL-8 MO000017265:IL-12 MO000017272:PIP3 MO000017462:CBP MO000017853:RON MO000019005:MKK6 MO000019331:TBK1 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000021201:iNOS MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000038410:MEK2{p} MO000038670:MEK1{p} MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 MO000080947:RelA-p65 MO000099621:CREB e1: e10:GSK3{p} e100:IFN inducible genes e101:dsRNA:TLR3:TRIF:TBK1:IKK-i:RIP1 e11:NO e12:Cyclooxygenase e13:LY294002 e14:TLR5:Flagellin e15:IL-8 e16:CREB:CBP e17:CREB{inactive} e18:p65:CBP e19: e2: e20: e21: e22:LPS:TLR4:MyD88 e23:LPS:TLR4:TIRAP e24:LPS:TLR4:TRAM e25:TLR2:PGN e26:TLR2:PGN:MyD88 e27:TLR2:PGN:MyD88:TIRAP e28:TLR7:ssRNA e29:TLR9:CpGDNA e3: e30:LPS:TLR4:MyD88:IRAK-4 e31:LPS:TLR4:MyD88:IRAK-4:IRAK1 e32:TLR2:PGN:MyD88:IRAK-4 e33:TLR2:PGN:MyD88:IRAK-4:IRAK1 e34:TLR2:PGN:MyD88:IRAK-4:IRAK1:TRAF6 e35:LPS:TLR4:MyD88:IRAK-4:IRAK1:TRAF6 e36:TAK1{active} e37:ssRNA e38:TLR9:CpGDNA:MyD88 e39:TLR9:CpGDNA:MyD88:IRAk-4 e4: e40:TLR7:ssRNA:MyD88 e41:TLR7:ssRNA:MyD88:IRAK4 e42:TLR7:ssRNA:MyD88:IRAK4:IRAK1 e43:TLR9:CpGDNA:MyD88:IRAk-4:IRAK1 e44:TLR7:ssRNA:MyD88:IRAK4:IRAK1:TRAF6 e45:TLR9:CpGDNA:MyD88:IRAk-4:IRAK1:TRAF6 e46:IKK{active} e47:IKappaB:NF-KappaB e48:IKappaB{p}:NF-KappaB e49:IKappaB{p}{ub}:NF-KappaB e5:wortmannin e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:TLR4 e60: e61: e62: e63:degradants e64:NF-kappaB e65:Inflammatory cytokines e66:MKK6{active} e67:MKK3{active} e68:p38{active} e69:JNK{active} e7: e70:IRF-7{p} e71:IRF-7{p} e72:CAMP dependent kinase e73:NF-kappaB e74:TNF-alpha e75:IL-12 e76:AP-1{active} e77:Egr-1{active} e78:Inhibitors of PI3K e79:p85 e8: e80:PI3K{active} e81:LPS:TLR4:MyD88:p85 e82:TLR5:Flagellin:MyD88 e83:TLR5:Flagellin:MyD88:p85 e84:p85 receptor e85:p85:p85 receptor e86:TLR2:PGN:p85 e87:TLR3:dsRNA:TRIF:p85 e88:TRIF:p110alpha e89:RIP1:p85 e9: e90:AKT{active} e91:CpGDNA e92:TNF-alpha receptor e93:TNF-alpha:TNF-alpha receptor e94:Src-family tyrosine kinase e95:Src family tyrosine kinase:TRAF6 e96:LPS:TLR4:TRAM:TRIF e97:LPS:TLR4:TRAM:TRIF:TBK1:IKK-i:Rip1 e98:IRF-3{p} e99:IRF-3{p}

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
551.0, 877.0
22.0, 22.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p109

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
669.0, 943.0
25.0, 25.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p9 p10

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
623.0, 857.0
21.0, 21.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
560.0, 832.0
24.0, 24.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p70 p73 p76 p77 p81

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
642.0, 746.0
28.0, 28.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p3 p6 p106 p115

p7

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
313.0, 867.0
18.0, 18.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57 p58

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
359.0, 973.0
22.0, 22.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p60

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
684.0, 458.0
23.5, 23.5

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p66 p68 p84 p85 p86 p87 p88 p92 p93 p95 p104

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
324.0, 1066.0
20.0, 20.0

Cot

--

MO000000041

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61 p62

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000041

--

Go back
367.0, 1237.0
22.0, 22.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63 p100 p101

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
904.0, 682.0
20.0, 20.0

NF-kappaB{active}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52 p67 p114

p53

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
643.0, 1067.0
18.0, 18.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p99 p100 p101 p105 p111

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
420.0, 1030.0
20.0, 20.0

MEK1

--

MO000000078

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000078

--

Go back
646.0, 1248.0
24.0, 24.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
467.0, 449.0
22.0, 22.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
378.0, 496.0
23.0, 23.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
468.0, 314.0
20.0, 20.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p34 p42 p43 p103 p105 p111

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
781.0, 435.0
18.0, 18.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p32 p40 p41 p85 p92 p93

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
471.0, 555.0
25.0, 25.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p49

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
569.0, 1051.0
18.0, 18.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p82

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1194.0, 1056.0
23.0, 23.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p68 p71 p74 p78 p79

p102

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
899.0, 381.0
22.0, 22.0

PIP2

--

MO000000331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m290229

10

false

infinite

0

unit false false false
TRANSPATHMO000000331

--

Go back
1196.0, 1006.0
20.0, 20.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9 p10

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
318.0, 1016.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p107 p112

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
590.0, 336.0
24.0, 24.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p113

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
336.0, 1134.0
20.0, 20.0

MEK2

--

MO000009393

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m1135

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000009393

--

Go back
579.0, 305.0
22.0, 22.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p24 p27 p28 p38 p90

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
476.0, 422.0
28.0, 28.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p45

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1236.0, 660.0
24.0, 24.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p66

p93

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
370.0, 444.0
23.0, 23.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
411.0, 289.0
22.0, 22.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p105 p111

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
164.0, 630.0
20.0, 20.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p92

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
1199.0, 753.0
22.0, 22.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70 p73 p76 p77 p81

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
433.0, 27.0
25.0, 25.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
499.0, 1193.0
22.0, 22.0

GSK3

--

MO000016941

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p63 p64 p65

true true true true

csml-variable:Double

m1853

10

false

infinite

0

unit false false false
TRANSPATHMO000016941

--

Go back
390.0, 670.0
19.0, 19.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
635.0, 597.0
22.0, 22.0

IGF-1

--

MO000017094

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m1985

10

false

infinite

0

unit false false false
InterProIPR004825
TRANSPATHMO000017094

--

Go back
613.0, 381.0
22.5, 22.5

SHIP

--

MO000017112

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m2000

10

false

infinite

0

unit false false false
InterProIPR000300
TRANSPATHMO000017112

--

Go back
406.0, 226.0
20.0, 20.0

Egr-1

--

MO000017190

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m2058

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000017190

--

Go back
995.0, 1205.0
22.0, 22.0

p110alpha

--

MO000017257

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p98

true true true true

csml-variable:Double

m2113

10

false

infinite

0

unit false false false
InterProIPR002420
TRANSPATHMO000017257

--

Go back
1192.0, 934.0
20.0, 20.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p12

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
1199.0, 639.0
26.0, 26.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69 p72 p75 p80

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
762.0, 392.0
23.5, 23.5

PIP3

--

MO000017272

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m157492

10

false

infinite

0

unit false false false
TRANSPATHMO000017272

--

Go back
808.0, 1126.0
20.0, 20.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p17

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
1125.0, 269.0
21.0, 21.0

RON

--

MO000017853

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m2603

10

false

infinite

0

unit false false false
TRANSPATHMO000017853

--

Go back
327.0, 549.0
22.0, 22.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
440.0, 178.0
20.0, 20.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p105 p111

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
455.0, 101.0
22.0, 22.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
246.0, 304.0
24.0, 24.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
996.0, 478.0
20.0, 20.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1120.0, 878.0
20.0, 20.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
908.0, 736.0
24.0, 24.0

iNOS

--

MO000021201

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m5576

10

false

infinite

0

unit false false false
TRANSPATHMO000021201

--

Go back
1207.0, 865.0
22.0, 22.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
1188.0, 462.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Complex

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
648.0, 282.0
20.0, 20.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p25

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
356.0, 1186.0
19.0, 19.0

MEK2{p}

--

MO000038410

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

--

true true true true

csml-variable:Double

m16620

10

false

infinite

0

unit false false false
TRANSPATHMO000038410

--

Go back
486.0, 1038.0
20.0, 20.0

MEK1{p}

--

MO000038670

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61

--

true true true true

csml-variable:Double

m16860

10

false

infinite

0

unit false false false
TRANSPATHMO000038670

--

Go back
705.0, 343.0
18.0, 18.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30 p35 p39

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
688.0, 262.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p26 p98

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
826.0, 193.5
20.5, 20.5

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
947.0, 471.0
18.0, 18.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p97 p111

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
965.0, 455.0
18.0, 18.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

p21 p87

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1014.0, 276.0
16.0, 16.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
168.0, 230.0
20.0, 20.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
985.0, 323.0
18.0, 18.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p37

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
966.0, 1124.0
24.0, 24.0

RelA-p65

--

MO000080947

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m55295

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000080947

--

Go back
695.0, 1169.0
22.0, 22.0

CREB

--

MO000099621

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p16

true true true true

csml-variable:Double

m72672

10

false

infinite

0

unit false false false
TRANSPATHMO000099621

--

Go back
224.75193877189054, 72.44747381544776
946.7113855147737, 1374.6249317674485

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
439.0, 1301.0
22.0, 22.0

GSK3{p}

--

e10

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63 p64 p65

--

true true true true

csml-variable:Double

m10

10

false

infinite

0

unit false false false
TRANSPATHMO000016941

--

Go back
533.0, 795.0
33.16608996539792, 17.688581314878896

IFN inducible genes

--

e100

cso30:c:mRNA

cso30:i:CC_Extracellular

--

p110

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1060.0, 328.0
19.6764705882353, 32.794117647058826

dsRNA:TLR3:TRIF:TBK1:IKK-i:RIP1

--

e101

cso30:c:Complex

cso30:i:CC_Extracellular

--

p111

p112

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
397.0, 416.0
41.732548359966366, 23.6484440706476

NO

--

e11

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p2 p13 p14

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
505.0, 753.0
42.820069204152254, 22.837370242214533

Cyclooxygenase

--

e12

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1185.0, 576.0
42.89318755256517, 24.30613961312027

LY294002

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p9 p11 p13 p115

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1124.5, 791.0
22.041876781407584, 42.661696996272745

TLR5:Flagellin

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9 p10 p11 p12 p13 p14 p69 p70 p71 p88 p90

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
709.0, 873.0
42.820069204152254, 22.837370242214533

IL-8

--

e15

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p11 p12

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
826.5, 1238.0
22.37293784369272, 27.39543409431762

CREB:CBP

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
703.0, 1229.0
22.0, 22.0

CREB{inactive}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

--

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000099621

--

Go back
894.5, 1198.0
22.37293784369272, 27.39543409431762

p65:CBP

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
865.8931219539945, 196.9850378320977
217.3600591659868, 362.8807767432156

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
224.75193877189054, 72.44747381544776
946.7113855147737, 1374.6249317674485

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
865.8931219539945, 196.9850378320977
217.3600591659868, 362.8807767432156

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false true false

--

Go back
865.8931219539945, 196.9850378320977
217.3600591659868, 362.8807767432156

--

e21

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false true false

--

Go back
626.5, 92.0
23.10589098917233, 32.240778124426505

LPS:TLR4:MyD88

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p29 p89

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
658.5, 76.0
23.10589098917233, 32.240778124426505

LPS:TLR4:TIRAP

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
763.5, 97.0
21.480271609469632, 29.972472013213437

LPS:TLR4:TRAM

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p26

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
251.5, 252.0
20.872834904626178, 40.39903529927648

TLR2:PGN

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24 p25 p72 p73 p74 p84 p96

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
250.5, 204.0
22.995412002202237, 32.08662139842173

TLR2:PGN:MyD88

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p30

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
251.0, 149.0
22.676470588235297, 37.794117647058826

TLR2:PGN:MyD88:TIRAP

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1006.5, 438.0
14.212014909011183, 27.50712563034423

TLR7:ssRNA

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
929.5, 203.0
17.250164437623333, 33.38741504056129

TLR9:CpGDNA

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p28 p76 p79 p80 p86 p101

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
243.68616648218602, 91.38170152574324
908.8429300941825, 1336.7564763468595

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
867.0, 85.0
22.764705882352942, 37.941176470588246

LPS:TLR4:MyD88:IRAK-4

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p31

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
983.0, 73.0
22.764705882352942, 37.941176470588246

LPS:TLR4:MyD88:IRAK-4:IRAK1

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p34

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
255.0, 97.0
22.764705882352942, 37.941176470588246

TLR2:PGN:MyD88:IRAK-4

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p32

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
327.0, 81.0
22.764705882352942, 37.941176470588246

TLR2:PGN:MyD88:IRAK-4:IRAK1

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
251.0, 353.0
22.764705882352942, 37.941176470588246

TLR2:PGN:MyD88:IRAK-4:IRAK1:TRAF6

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p44

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1107.0, 97.0
22.764705882352942, 37.941176470588246

LPS:TLR4:MyD88:IRAK-4:IRAK1:TRAF6

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p45

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
606.0, 458.0
28.0, 28.0

TAK1{active}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44 p45

p49 p55 p56

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1196.0, 330.5
36.1631221223416, 18.684279763209823

ssRNA

--

e37

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p37

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
908.5, 295.0
18.35529454945862, 25.612038906221326

TLR9:CpGDNA:MyD88

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p28

p35

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
938.0, 254.0
16.41176470588236, 27.352941176470598

TLR9:CpGDNA:MyD88:IRAk-4

--

e39

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p35

p41

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
278.71448774623275, 124.51660001876002
838.7862875660898, 1270.4866793608235

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
948.5, 399.0
18.35529454945862, 25.612038906221326

TLR7:ssRNA:MyD88

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p38

p39

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
953.0, 350.0
17.382352941176467, 28.97058823529411

TLR7:ssRNA:MyD88:IRAK4

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
919.0, 526.0
17.382352941176467, 28.97058823529411

TLR7:ssRNA:MyD88:IRAK4:IRAK1

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p42

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1046.0, 302.0
16.41176470588236, 27.352941176470598

TLR9:CpGDNA:MyD88:IRAk-4:IRAK1

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p41

p43

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
955.0, 506.0
17.382352941176467, 28.97058823529411

TLR7:ssRNA:MyD88:IRAK4:IRAK1:TRAF6

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p113

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
986.0, 234.0
16.41176470588236, 27.352941176470598

TLR9:CpGDNA:MyD88:IRAk-4:IRAK1:TRAF6

--

e45

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p43

p46

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
609.0, 531.0
25.0, 25.0

IKK{active}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p50

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
767.5, 548.0
20.33161139810032, 24.895850691551416

IKappaB:NF-KappaB

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
681.5, 580.0
20.33161139810032, 24.895850691551416

IKappaB{p}:NF-KappaB

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
864.5, 626.0
15.791701383102822, 19.33677720379937

IKappaB{p}{ub}:NF-KappaB

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p52

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
176.0, 419.0
44.78553406223717, 25.378469301934402

wortmannin

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2 p4 p7 p10 p12 p14 p106

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
425.11655704556995, 626.1920158573821
417.6378314305411, 378.7516273867291

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
470.22455373639184, 635.1678788081892
244.20536139513953, 367.0857661735855

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
430.5606256117036, 631.2472223830775
406.74969429827405, 368.641214335338

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
431.33834969257975, 632.0249464639539
405.19424613652126, 367.0857661735855

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
425.11655704556995, 626.1920158573821
417.6378314305411, 378.7516273867291

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
425.11655704556995, 626.1920158573821
417.6378314305411, 378.7516273867291

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
431.33834969257975, 632.0249464639539
405.19424613652126, 367.0857661735855

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
729.9843967490561, 781.7368320326304
26.091716995014025, 23.61987012180218

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
661.5446776319466, 890.6182033553041
73.88378768324284, 66.88427095535671

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
425.11655704556995, 626.1920158573821
417.6378314305411, 378.7516273867291

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
515.5, 84.0
20.63494847621136, 39.938609953957474

LPS:TLR4

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2 p4 p6 p7 p18 p19 p22 p66 p67 p68 p75 p77 p78 p82 p83 p85 p100 p105 p114 p106 p115

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
523.5514440274173, 794.5061094175833
13.225976467072588, 6.368062743405317

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
523.1097912359762, 775.5150393856204
45.26941112270193, 81.48494002086343

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
542.1008612679395, 828.5133743585399
7.066444663055909, 7.066444663055903

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1005.0, 577.0
22.452613440551403, 21.704192992533024

degradants

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
782.0, 798.0
20.0, 20.0

NF-kappaB

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p54

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
602.0, 781.0
39.44636678200692, 21.038062283737023

Inflammatory cytokines

--

e65

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p54

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
351.0, 705.0
22.0, 22.0

MKK6{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p58 p60

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
312.0, 726.0
19.0, 19.0

MKK3{active}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56

p57 p59

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
393.0, 871.0
18.0, 18.0

p38{active}

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57 p58

--

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
423.0, 925.0
22.0, 22.0

JNK{active}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59 p60

--

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
226.52482267470208, 126.79250209252668
908.0944453618893, 1286.7463727637094

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
534.0, 544.0
24.0, 24.0

IRF-7{p}

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46 p113

p47

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
590.0, 740.0
24.0, 24.0

IRF-7{p}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
530.5, 1355.0
15.815657073857915, 25.647011471120948

CAMP dependent kinase

--

e72

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p64

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1024.0, 674.0
20.0, 20.0

NF-kappaB

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67 p114

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
558.0, 930.0
36.43598615916955, 19.432525951557093

TNF-alpha

--

e74

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p68 p71 p74 p78 p79

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
614.0, 894.0
36.43598615916955, 19.43252595155709

IL-12

--

e75

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p69 p72 p75 p80

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
681.0, 1043.0
18.0, 18.0

AP-1{active}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p82

--

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
468.0, 266.0
20.0, 20.0

Egr-1{active}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

--

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000017190

--

Go back
183.0, 533.0
13.06080449017773, 30.140318054256305

Inhibitors of PI3K

--

e78

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p82 p83 p114

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1021.0, 624.5
21.616871704745172, 14.05096660808436

p85

--

e79

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p89 p91 p94 p96 p97 p99

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
228.37828847981328, 137.2421745573058
874.7818938224198, 1270.1833098301518

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
332.0, 408.0
23.5, 23.5

PI3K{active}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p84 p85 p86 p87 p88 p92 p93 p95 p104

p67

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1124.0, 515.0
19.852941176470583, 33.088235294117645

LPS:TLR4:MyD88:p85

--

e81

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p89

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1123.5, 622.0
20.154523765828593, 28.122591301156174

TLR5:Flagellin:MyD88

--

e82

cso30:c:Complex

cso30:i:CC_Extracellular

--

p90

p91

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1123.0, 418.0
21.617647058823533, 36.02941176470588

TLR5:Flagellin:MyD88:p85

--

e83

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p91

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1126.5, 315.0
22.275922671353257, 34.2706502636204

p85 receptor

--

e84

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p94

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1123.5, 367.0
21.831177373383028, 42.25389169041877

p85:p85 receptor

--

e85

cso30:c:Complex

cso30:i:CC_Extracellular

--

p94

p95

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
247.5, 597.0
21.48027160946963, 29.97247201321344

TLR2:PGN:p85

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p96

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1048.0, 392.0
19.676470588235293, 32.794117647058826

TLR3:dsRNA:TRIF:p85

--

e87

cso30:c:Complex

cso30:i:CC_Extracellular

--

p97

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
886.5, 1078.0
22.74037660389935, 27.845359106815533

TRIF:p110alpha

--

e88

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p98

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
600.5, 1124.0
19.531411431428097, 23.91601399766707

RIP1:p85

--

e89

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p99

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
248.97215179819418, 168.62661341202505
882.9668005757493, 1271.0568683916968

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
623.0, 1313.0
22.0, 22.0

AKT{active}

--

e90

cso30:c:Protein

cso30:i:CC_CellComponent

--

p100 p101

--

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1186.0, 230.0
48.29875518672199, 12.87966804979253

CpGDNA

--

e91

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1123.5, 1119.0
21.613356766256587, 33.25131810193321

TNF-alpha receptor

--

e92

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p102

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1123.5, 1188.0
20.621354966016224, 39.912299934224954

TNF-alpha:TNF-alpha receptor

--

e93

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p102

p103

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
864.0, 1333.0
12.683816651075773, 29.27034611786716

Src-family tyrosine kinase

--

e94

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p103

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
761.5, 1285.0
17.49825029161805, 21.42642892851191

Src family tyrosine kinase:TRAF6

--

e95

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p103

p104

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1123.0, 162.0
21.617647058823533, 36.029411764705884

LPS:TLR4:TRAM:TRIF

--

e96

cso30:c:Complex

cso30:i:CC_Extracellular

--

p26

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
406.0, 67.0
20.735294117647058, 34.55882352941177

LPS:TLR4:TRAM:TRIF:TBK1:IKK-i:Rip1

--

e97

cso30:c:Complex

cso30:i:CC_Extracellular

--

p105

p107

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
426.0, 992.0
24.0, 24.0

IRF-3{p}

--

e98

cso30:c:Protein

cso30:i:CC_CellComponent

--

p107 p112

p108

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
474.0, 896.0
24.0, 24.0

IRF-3{p}

--

e99

cso30:c:Protein

cso30:i:CC_CellComponent

--

p108

p109 p110

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
515.0, 29.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019394

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17827709,9398628 Prior to the discovery of TLR, wortmannin was reported to enhance LPS-induced NO production in macrophages

Go back
865.0, 881.0
21.0, 21.0

p9

p10

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e14 e5

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c32 : 1

m93248*m14*m5*0.1

nodelay

--

true

0

false

PMID: 17827709,16670329 In epithelial cells, flagellin-induced (TLR5-mediated) production of NO, IL-6, and IL-8 was increased in the presence of wortmannin or LY294002

Go back
548.0, 1130.0
20.0, 20.0

p100

p100

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000048 e6 MO000000065

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c305 : 1
stoichiometry:c306 : 1
stoichiometry:c304 : 1

m78*m6*m97*0.1

nodelay

--

true

0

false

PMID: 17827709,15280422 RIP1 is another candidate for the adaptor of p85 in TLR signaling, since neither LPS nor CpG activates Akt in cells lacking RIP1.

Go back
484.0, 1090.0
20.0, 20.0

p100

p101

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000048 MO000000065 e29

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c307 : 1
stoichiometry:c309 : 1
stoichiometry:c310 : 1
stoichiometry:c308 : 1

m78*m97*m31*0.1

nodelay

--

true

0

false

PMID: 17827709,15280422 RIP1 is another candidate for the adaptor of p85 in TLR signaling, since neither LPS nor CpG activates Akt in cells lacking RIP1.

Go back
1196.0, 1126.0
19.0, 19.0

p102

p102

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000289 e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c311 : 1
stoichiometry:c312 : 1
stoichiometry:c313 : 1

m230*m101*0.1

nodelay

--

true

0

false

--

Go back
920.0, 1294.0
19.0, 19.0

p103

p103

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e94 MO000000212 e93

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c314 : 1
stoichiometry:c315 : 1
stoichiometry:c316 : 1
stoichiometry:c317 : 1

m103*m183*m102*0.1

nodelay

--

true

0

false

PMID: 17827709,10635328 Stimulation of TNF receptors induces the binding of TRAF6 to Src-family tyrosine kinases to activate PI3K.

Go back
392.0, 758.0
19.0, 19.0

p104

p104

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e95 MO000000030

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c318 : 1
stoichiometry:c319 : 1
stoichiometry:c320 : 1

m104*m27*0.1

nodelay

--

true

0

false

PMID: 17827709,10635328 Stimulation of TNF receptors induces the binding of TRAF6 to Src-family tyrosine kinases to activate PI3K.

Go back
605.0, 165.0
21.0, 21.0

p105

p105

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019331 MO000000212 MO000000065 MO000016608 e6

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c323 : 1
stoichiometry:c324 : 1
stoichiometry:c325 : 1
stoichiometry:c327 : 1
stoichiometry:c326 : 1

m3902*m183*m97*m1599*m6*0.1

nodelay

--

true

0

false

PMID: 17827709 This pathway requires a TIR domain-containing adaptor TICAM1/TRIF that interacts with TBK1, IKKi, RIP1, and TRAF6.

Go back
585.0, 713.0
21.0, 21.0

p6

p106

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6 e5

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c355 : 1
stoichiometry:c358 : 1
stoichiometry:c360 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 17827709,9794431 The activation of a receptor tyrosine kinase, RON, inhibits the LPS-induced expression of iNOS in murine peritoneal macrophages; this inhibition is recovered by wortmannin administration. PMID: 17827709,10868937 In b -pancreatic cells, LPS induces the expression of iNOS, which is abrogated by insulinlike growth factor-1 (IGF-1) PMID: 17827709 The effect of IGF-1 is inhibited by wortmannin, LY294002, and the overexpression of Dp85.

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356.0, 810.0
19.0, 19.0

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

MO000007694 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c328 : 1
stoichiometry:c330 : 1
stoichiometry:c329 : 1

m977*m106*0.1

nodelay

--

true

0

false

PMID: 17827709 The nuclear translocation of IRF3 is triggered by phosphorylation with TBK1 and IKKi.

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500.0, 990.0
19.0, 19.0

p108

p108

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c331 : 1
stoichiometry:c332 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 17827709 The nuclear translocation of IRF3 is triggered by phosphorylation with TBK1 and IKKi.

Go back
492.0, 846.0
19.0, 19.0

p109

p109

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e99

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c333 : 1
stoichiometry:c334 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17827709 Treatment of macrophages and dendritic cells (DCs) with dsRNA or LPS results in IRF3 activation, which leads to the expression of IFN-b and the IFN-inducible gene products.

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871.0, 841.0
21.0, 21.0

p9

p11

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e14 e13 e15

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c38 : 1
stoichiometry:c37 : 1

m14*m13*m15*0.1

nodelay

--

true

0

false

PMID: 17827709,16670329 In epithelial cells, flagellin-induced (TLR5-mediated) production of NO, IL-6, and IL-8 was increased in the presence of wortmannin or LY294002

Go back
464.0, 826.0
19.0, 19.0

p109

p110

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e99

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c335 : 1
stoichiometry:c336 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17827709 Treatment of macrophages and dendritic cells (DCs) with dsRNA or LPS results in IRF3 activation, which leads to the expression of IFN-b and the IFN-inducible gene products.

Go back
665.0, 189.0
21.0, 21.0

p105

p111

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041437 MO000019331 MO000000212 MO000016608 MO000000065

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1
stoichiometry:c339 : 1
stoichiometry:c340 : 1
stoichiometry:c341 : 1
stoichiometry:c342 : 1

m19305*m3902*m183*m1599*m97*0.1

nodelay

--

true

0

false

PMID: 17827709 This pathway requires a TIR domain-containing adaptor TICAM1/TRIF that interacts with TBK1, IKKi, RIP1, and TRAF6.

Go back
400.0, 810.0
19.0, 19.0

p107

p112

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

MO000007694 e101

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c343 : 1
stoichiometry:c345 : 1
stoichiometry:c344 : 1

m977*m110*0.1

nodelay

--

true

0

false

PMID: 17827709 The nuclear translocation of IRF3 is triggered by phosphorylation with TBK1 and IKKi.

Go back
527.0, 365.0
21.0, 21.0

p46

p113

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e44 MO000007702

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c346 : 1
stoichiometry:c347 : 1
stoichiometry:c348 : 1

m46*m980*0.1

nodelay

--

true

0

false

PMID: 17827709,15361868 Formation of a signaling complex consisting of MyD88, IRAKs, and TRAF6 induces the phosphorylation of IRF7 by IRAK-1 and allows the nuclear translocation of this transcription factor

Go back
974.0, 666.0
19.0, 19.0

p67

p114

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e73 e78 e6

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c349 : 1
stoichiometry:c351 : 1
stoichiometry:c352 : 1
stoichiometry:c350 : 1

m80*m85*m6*0.1

nodelay

--

true

0

false

PMID: 17827709,11714830 In lung neutrophils, LPS-induced activation of NF-k B and the production of IL-1b and TNF-a are inhibited by PI3K inhibition. PMID: 17827709,12052830 In human monocytic THP1 cells, as well as in human peripheral blood monocytes, inhibitors of PI3K and a dominant negative Akt enhance the LPS-induced activation of AP-1, Egr-1, and NF-k B, which results in increased production of TNF-a

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637.0, 685.0
21.0, 21.0

p6

p115

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13 e6

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c357 : 1
stoichiometry:c359 : 1
stoichiometry:c361 : 1

m13*m6*0.1

nodelay

--

true

0

false

PMID: 17827709,9794431 The activation of a receptor tyrosine kinase, RON, inhibits the LPS-induced expression of iNOS in murine peritoneal macrophages; this inhibition is recovered by wortmannin administration. PMID: 17827709,10868937 In b -pancreatic cells, LPS induces the expression of iNOS, which is abrogated by insulinlike growth factor-1 (IGF-1) PMID: 17827709 The effect of IGF-1 is inhibited by wortmannin, LY294002, and the overexpression of Dp85.

Go back
953.0, 849.0
21.0, 21.0

p9

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e14 e5 e15

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c353 : 1
stoichiometry:c39 : 1

m14*m5*m15*0.1

nodelay

--

true

0

false

PMID: 17827709,16670329 In epithelial cells, flagellin-induced (TLR5-mediated) production of NO, IL-6, and IL-8 was increased in the presence of wortmannin or LY294002

Go back
813.0, 521.0
21.0, 21.0

p13

p13

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e14 e13

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1
stoichiometry:c43 : 1

m14*m13*0.1

nodelay

--

true

0

false

PMID: 17827709,16670329 In epithelial cells, flagellin-induced (TLR5-mediated) production of NO, IL-6, and IL-8 was increased in the presence of wortmannin or LY294002

Go back
827.0, 589.0
21.0, 21.0

p13

p14

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e5 e14

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m5*m14*0.1

nodelay

--

true

0

false

PMID: 17827709,16670329 In epithelial cells, flagellin-induced (TLR5-mediated) production of NO, IL-6, and IL-8 was increased in the presence of wortmannin or LY294002

Go back
766.0, 1184.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000099621 MO000017462

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m72672*m2282*0.1

nodelay

--

true

0

false

PMID: 17827709 GSK-3 can differentially regulate the production of pro-inflammatory and anti-inflammatory cytokines by affecting the relative amounts of active transcription factors, CREB and the p65 subunit of NF-k B, that interact with a common coactivator CBP (CREB-binding protein).

Go back
608.0, 1170.0
19.0, 19.0

p16

p16

cso30:i:ME_UnknownInactivation

cso30:i:CC_Cytosol

--

MO000099621 MO000016941

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m72672*m1853*0.1

nodelay

--

true

0

false

PMID: 17827709,16007092 Since GSK-3 inactivates CREB, the inhibition of GSK- 3 augments the binding of CREB to CBP and competitively suppresses the binding of NF-k B p65 to the coactivator

Go back
894.0, 1124.0
23.0, 23.0

p15

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000080947 MO000017462

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m55295*m2282*0.1

nodelay

--

true

0

false

PMID: 17827709 GSK-3 can differentially regulate the production of pro-inflammatory and anti-inflammatory cytokines by affecting the relative amounts of active transcription factors, CREB and the p65 subunit of NF-k B, that interact with a common coactivator CBP (CREB-binding protein). PMID: 17827709,16007092 Since GSK-3 inactivates CREB, the inhibition of GSK- 3 augments the binding of CREB to CBP and competitively suppresses the binding of NF-k B p65 to the coactivator

Go back
572.0, 226.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000016573

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
652.0, 218.0
19.0, 19.0

p18

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e6

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m6810*m6*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
369.0, 349.0
21.0, 21.0

p2

p2

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e6 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 17827709,9398628 Prior to the discovery of TLR, wortmannin was reported to enhance LPS-induced NO production in macrophages

Go back
1076.0, 466.0
19.0, 19.0

p18

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
842.0, 470.0
19.0, 19.0

p18

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
756.0, 174.0
19.0, 19.0

p18

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000041132

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m6*m19005*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
168.0, 306.0
19.0, 19.0

p18

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042032 MO000019397

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m155701*m3964*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
352.0, 262.0
19.0, 19.0

p18

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000016573

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m26*m1572*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
352.0, 226.0
19.0, 19.0

p18

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000022528

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m26*m6810*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
704.0, 194.0
19.0, 19.0

p18

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000041125

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c321 : 1

m25*m18998*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
840.0, 322.0
19.0, 19.0

p18

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 MO000016573

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m19940*m1572*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
828.0, 306.0
19.0, 19.0

p18

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e29

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c88 : 1
stoichiometry:c87 : 1

m1572*m31*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
692.0, 150.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000039077

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m23*m17258*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
696.0, 696.0
23.0, 23.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000030

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17827709,10229863 The role of PI3K in this regulation was confirmed by the finding that a dominant negative mutant of PI3K (p110DN) increased, while a constitutively active form of PI3K (p110CAAT) suppressed the expression of inducible NO synthase (iNOS).

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372.0, 194.0
20.0, 20.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000039077

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m28*m17258*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
792.0, 162.0
19.0, 19.0

p29

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000000213

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m32*m184*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
392.0, 166.0
20.0, 20.0

p29

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m184*m34*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
328.0, 314.0
20.0, 20.0

p29

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 MO000000212

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m35*m183*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
864.0, 170.0
20.0, 20.0

p29

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e31

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m183*m33*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
760.0, 290.0
19.0, 19.0

p29

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c107 : 1
stoichiometry:c112 : 1

m17258*m40*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
1056.0, 242.0
19.0, 19.0

p18

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e91

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m19828*m100*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
1004.0, 362.0
19.0, 19.0

p18

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000042126

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m39*m19940*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
844.0, 422.0
19.0, 19.0

p18

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e28

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m1572*m30*0.1

nodelay

--

true

0

false

PMID: 17827709,14698224,12539043,14519765,14556004 MyD88 is shared by all TLRs except TLR3, while TIRAP/Mal only binds to TLR2 and TLR4,TICAM- 1/TRIF binds exclusively to TLR3 and TLR4,and TICAM-2/TRAM binds only to TLR4.

Go back
832.0, 386.0
19.0, 19.0

p29

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000039077

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m42*m17258*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
519.0, 697.0
21.0, 21.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e6 e5

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c9 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 17827709,12072439 The induction of cyclooxygenase by LPS is enhanced in the presence of wortmannin

Go back
776.0, 346.0
19.0, 19.0

p29

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000000213

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m43*m184*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
740.0, 258.0
19.0, 19.0

p29

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 MO000000213

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m41*m184*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
782.0, 474.0
19.0, 19.0

p29

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000000212

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m44*m183*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
1024.0, 170.0
19.0, 19.0

p29

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000000212

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m45*m183*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
566.0, 394.0
20.0, 20.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000016574

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m36*m1573*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
472.0, 358.0
20.0, 20.0

p44

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 MO000016574

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m37*m1573*0.1

nodelay

--

true

0

false

PMID:17827709,9430229,12620219,10882101 MyD88 recruits IRAKs (IRAK1 and 4) to TLRs and allows IRAK1 to bind TRAF6, a key event leading to the activation of TAK1.

Go back
627.0, 421.0
21.0, 21.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e45 MO000007702

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m47*m980*0.1

nodelay

--

true

0

false

PMID: 17827709,15361868 Formation of a signaling complex consisting of MyD88, IRAKs, and TRAF6 induces the phosphorylation of IRF7 by IRAK-1 and allows the nuclear translocation of this transcription factor

Go back
435.0, 661.0
22.0, 22.0

p47

p47

cso30:i:ME_Translocation

cso30:i:CC_Extracellular

--

e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 17827709,15361868 Formation of a signaling complex consisting of MyD88, IRAKs, and TRAF6 induces the phosphorylation of IRF7 by IRAK-1 and allows the nuclear translocation of this transcription factor

Go back
423.0, 473.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016599 MO000000210 MO000000211

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m1593*m181*m182*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 activates the IKK complex consisting of IKKa , IKKb , and NEMO/IKKg

Go back
508.0, 482.0
19.0, 19.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000000248

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m38*m207*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 activates the IKK complex consisting of IKKa , IKKb , and NEMO/IKKg

Go back
661.0, 333.0
21.0, 21.0

p5

p5

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

MO000017112 MO000017272

MO000000331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m2000*m157492*0.1

nodelay

--

true

0

false

PMID: 17827709 SHIP is a lipid phosphatase that metabolizes PtdIns-3,4,5- P3 (PIP3) to produce PtdIns-3,4-P

Go back
644.0, 458.0
19.0, 19.0

p50

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e47 e46

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m49*m48*0.1

nodelay

--

true

0

false

PMID: 17827709 The activated IKK complex phosphorylates Ik B leading to its ubiquitination

Go back
740.0, 598.0
19.0, 19.0

p51

p51

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 17827709 The activated IKK complex phosphorylates Ik B leading to its ubiquitination

Go back
946.0, 598.0
19.0, 19.0

p52

p52

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e49

e63 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 17827709 The resultant degradation of Ik B enables the bound NF-k B to translocate into the nucleus and to induce the expression of inflammatory cytokines.

Go back
810.0, 678.0
19.0, 19.0

p53

p53

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

MO000000058

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17827709 The resultant degradation of Ik B enables the bound NF-k B to translocate into the nucleus and to induce the expression of inflammatory cytokines.

Go back
687.0, 805.0
21.0, 21.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 17827709 The resultant degradation of Ik B enables the bound NF-k B to translocate into the nucleus and to induce the expression of inflammatory cytokines.

Go back
309.0, 609.0
21.0, 21.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e36 MO000019005

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m38*m3613*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 has the ability to act as a MAPK kinase kinase and is known to activate MAPK kinases, including MKK3/6, which in turn activate p38MAPK and SAPK/JNK.

Go back
312.0, 662.0
19.0, 19.0

p55

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000016966 e36

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m1875*m38*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 has the ability to act as a MAPK kinase kinase and is known to activate MAPK kinases, including MKK3/6, which in turn activate p38MAPK and SAPK/JNK.

Go back
312.0, 786.0
19.0, 19.0

p55

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e67 MO000000022

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m69*m70*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 has the ability to act as a MAPK kinase kinase and is known to activate MAPK kinases, including MKK3/6, which in turn activate p38MAPK and SAPK/JNK.

Go back
372.0, 762.0
19.0, 19.0

p55

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e66 MO000000022

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m68*m70*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 has the ability to act as a MAPK kinase kinase and is known to activate MAPK kinases, including MKK3/6, which in turn activate p38MAPK and SAPK/JNK.

Go back
352.0, 890.0
19.0, 19.0

p55

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e67 MO000000023

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m69*m72*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 has the ability to act as a MAPK kinase kinase and is known to activate MAPK kinases, including MKK3/6, which in turn activate p38MAPK and SAPK/JNK.

Go back
605.0, 681.0
21.0, 21.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e6 MO000017094 MO000017853

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c21 : 1
stoichiometry:c356 : 1
stoichiometry:c16 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17827709,9794431 The activation of a receptor tyrosine kinase, RON, inhibits the LPS-induced expression of iNOS in murine peritoneal macrophages; this inhibition is recovered by wortmannin administration. PMID: 17827709,10868937 In b -pancreatic cells, LPS induces the expression of iNOS, which is abrogated by insulinlike growth factor-1 (IGF-1) PMID: 17827709 The effect of IGF-1 is inhibited by wortmannin, LY294002, and the overexpression of Dp85.

Go back
300.0, 966.0
19.0, 19.0

p55

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e66 MO000000023

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c22 : 1

m68*m72*0.1

nodelay

--

true

0

false

PMID: 17827709,11460167 TAK1 has the ability to act as a MAPK kinase kinase and is known to activate MAPK kinases, including MKK3/6, which in turn activate p38MAPK and SAPK/JNK.

Go back
436.0, 1078.0
19.0, 19.0

p61

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000041 MO000000078

MO000038670

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m74*m75*0.1

nodelay

--

true

0

false

PMID: 17827709,15372110 Another MAPK kinase kinase, Cot/Tpl2, which phosphorylates MEK1/2, is also activated downstream of TLR, although the mechanism is yet unknown.

Go back
432.0, 1134.0
19.0, 19.0

p61

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000041 MO000009393

MO000038410

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m74*m1135*0.1

nodelay

--

true

0

false

PMID: 17827709,15372110 Another MAPK kinase kinase, Cot/Tpl2, which phosphorylates MEK1/2, is also activated downstream of TLR, although the mechanism is yet unknown.

Go back
441.0, 1227.0
18.0, 18.0

p63

p63

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000048 MO000016941

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m78*m1853*0.1

nodelay

--

true

0

false

PMID: 17827709,11035810,11884598 In addition to Akt, several other protein kinases, including cyclic AMP-dependent kinase and certain PKCs, are known to phosphorylate the inhibitory N-terminal site of GSK- 3.

Go back
531.0, 1289.0
21.0, 21.0

p63

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e72 MO000016941

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m79*m1853*0.1

nodelay

--

true

0

false

PMID: 17827709,11035810,11884598 In addition to Akt, several other protein kinases, including cyclic AMP-dependent kinase and certain PKCs, are known to phosphorylate the inhibitory N-terminal site of GSK- 3.

Go back
571.0, 1221.0
19.0, 19.0

p63

p65

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000104 MO000016941

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m92*m1853*0.1

nodelay

--

true

0

false

PMID: 17827709,11035810,11884598 In addition to Akt, several other protein kinases, including cyclic AMP-dependent kinase and certain PKCs, are known to phosphorylate the inhibitory N-terminal site of GSK- 3.

Go back
898.0, 710.0
19.0, 19.0

p66

p66

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010389 e6 MO000000030

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1
stoichiometry:c196 : 1

m93364*m6*m27*0.1

nodelay

--

true

0

false

PMID: 17827709,11714830 In lung neutrophils, LPS-induced activation of NF-k B and the production of IL-1b and TNF-a are inhibited by PI3K inhibition.

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954.0, 630.0
19.0, 19.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e6 e73 e80

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c199 : 1
stoichiometry:c202 : 1

m6*m80*m87*0.1

nodelay

--

true

0

false

PMID: 17827709,11714830 In lung neutrophils, LPS-induced activation of NF-k B and the production of IL-1b and TNF-a are inhibited by PI3K inhibition. PMID: 17827709,12052830 In human monocytic THP1 cells, as well as in human peripheral blood monocytes, inhibitors of PI3K and a dominant negative Akt enhance the LPS-induced activation of AP-1, Egr-1, and NF-k B, which results in increased production of TNF-a

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770.0, 1026.0
19.0, 19.0

p66

p68

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

MO000000030 e6 e74

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c206 : 1
stoichiometry:c205 : 1

m27*m6*m81*0.1

nodelay

--

true

0

false

PMID: 17827709,11714830 In lung neutrophils, LPS-induced activation of NF-k B and the production of IL-1b and TNF-a are inhibited by PI3K inhibition.

Go back
897.0, 773.0
21.0, 21.0

p69

p69

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e14 e75

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c208 : 1

m14*m82*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a Was found to be increases in p85 knockout mice.

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854.0, 730.0
20.0, 20.0

p7

p7

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010514 e6 e5

MO000021201

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c18 : 1

m93479*m6*m5*0.1

nodelay

--

true

0

false

PMID: 17827709,10066820 In C6 glial cells, LPS or wortmannin alone has no effect, but their combination induces iNOS production

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947.0, 737.0
21.0, 21.0

p69

p70

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e14 G010453

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m14*m93423*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a Was found to be increases in Dcs obtained from p85 knockout mice.

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841.0, 1005.0
21.0, 21.0

p69

p71

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e14 e74

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m14*m81*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a Was found to be increases in Dcs obtained from p85 knockout mice.

Go back
957.0, 717.0
21.0, 21.0

p69

p72

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e25 e75

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m26*m82*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
1029.0, 641.0
21.0, 21.0

p69

p73

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e25 G010453

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c221 : 1
stoichiometry:c219 : 1

m26*m93423*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
1033.0, 909.0
21.0, 21.0

p69

p74

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e74 e25

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c222 : 1

m81*m26*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
777.0, 649.0
21.0, 21.0

p69

p75

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e6 e75

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m6*m82*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
955.0, 809.0
21.0, 21.0

p69

p76

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010453 e29

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c242 : 1
stoichiometry:c243 : 1

m93423*m31*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
865.0, 685.0
21.0, 21.0

p69

p77

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010453 e6

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m93423*m6*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
969.0, 989.0
21.0, 21.0

p69

p78

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e74 e6

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1
stoichiometry:c232 : 1

m81*m6*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a Was found to be increases in Dcs obtained from p85 knockout mice.

Go back
729.0, 1049.0
21.0, 21.0

p69

p79

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e74 e29

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c236 : 1
stoichiometry:c237 : 1

m81*m31*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a Was found to be increases in Dcs obtained from p85 knockout mice.

Go back
1186.0, 804.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022185 MO000019399

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 17827709,16670329 In epithelial cells, flagellin-induced (TLR5-mediated) production of NO, IL-6, and IL-8 was increased in the presence of wortmannin or LY294002

Go back
825.0, 937.0
21.0, 21.0

p69

p80

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e75 e29

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1
stoichiometry:c240 : 1

m82*m31*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
993.0, 773.0
21.0, 21.0

p69

p81

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010453

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c354 : 1

m93423*0.1

nodelay

--

true

0

false

PMID: 17827709,9261174 In addition, TLR2-, TLR4-, TLR5-, and TLR9-mediated production of IL-12, IFN-g , and TNF-a was found to be increases in Dcs obtained from p85 knockout mice.

Go back
568.0, 614.0
19.0, 19.0

p82

p82

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000276 e6 e78

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c246 : 1
stoichiometry:c251 : 1
stoichiometry:c245 : 1

m219*m6*m85*0.1

nodelay

--

true

0

false

PMID: 17827709,12052830 In human monocytic THP1 cells, as well as in human peripheral blood monocytes, inhibitors of PI3K and a dominant negative Akt enhance the LPS-induced activation of AP-1, Egr-1, and NF-k B, which results in increased production of TNF-a

Go back
484.0, 202.0
19.0, 19.0

p82

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e6 MO000017190 e78

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1
stoichiometry:c250 : 1
stoichiometry:c249 : 1

m6*m2058*m85*0.1

nodelay

--

true

0

false

PMID: 17827709,12052830 In human monocytic THP1 cells, as well as in human peripheral blood monocytes, inhibitors of PI3K and a dominant negative Akt enhance the LPS-induced activation of AP-1, Egr-1, and NF-k B, which results in increased production of TNF-a

Go back
457.0, 337.0
21.0, 21.0

p84

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e25 MO000000030

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c254 : 1

m26*m27*0.1

nodelay

--

true

0

false

PMID: 17827709 It was shown that most TLRs, including at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate PI3K.

Go back
489.0, 273.0
21.0, 21.0

p84

p85

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e6 MO000000030 MO000000213

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1
stoichiometry:c284 : 1
stoichiometry:c257 : 1

m6*m27*m184*0.1

nodelay

--

true

0

false

PMID: 17827709 It was shown that most TLRs, including at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate PI3K. PMID: 17827709,12516562 It is reported that IL-1b -, IL-18-, and LPS-induced activation of PI3K is diminished in IRAK-1 deficient cells.

Go back
705.0, 369.0
21.0, 21.0

p84

p86

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e29 MO000000030

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c259 : 1
stoichiometry:c260 : 1

m31*m27*0.1

nodelay

--

true

0

false

PMID: 17827709 It was shown that most TLRs, including at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate PI3K.

Go back
789.0, 457.0
21.0, 21.0

p84

p87

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000041446 MO000000030

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c262 : 1
stoichiometry:c263 : 1

m19314*m27*0.1

nodelay

--

true

0

false

PMID: 17827709 It was shown that most TLRs, including at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate PI3K.

Go back
577.0, 585.0
21.0, 21.0

p84

p88

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e14 MO000000030

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c265 : 1
stoichiometry:c266 : 1

m14*m27*0.1

nodelay

--

true

0

false

PMID: 17827709 It was shown that most TLRs, including at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate PI3K.

Go back
914.0, 570.0
19.0, 19.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_EndosomeMembrane

--

e79 e22

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c267 : 1
stoichiometry:c268 : 1
stoichiometry:c269 : 1

m86*m23*0.1

nodelay

--

true

0

false

PMID: 17827709,16644730 In fact, MyD88 associates with p85 in response to flagellin and LPS

Go back
873.0, 953.0
21.0, 21.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e14 e13

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1

m93248*m14*m13*0.1

nodelay

--

true

0

false

PMID: 17827709,16670329 In epithelial cells, flagellin-induced (TLR5-mediated) production of NO, IL-6, and IL-8 was increased in the presence of wortmannin or LY294002

Go back
1070.0, 630.0
19.0, 19.0

p89

p90

cso30:i:ME_Binding

cso30:i:CC_EndosomeMembrane

--

e14 MO000016573

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c271 : 1
stoichiometry:c272 : 1

m14*m1572*0.1

nodelay

--

true

0

false

PMID: 17827709,16644730 In fact, MyD88 associates with p85 in response to flagellin and LPS

Go back
1066.0, 546.0
19.0, 19.0

p89

p91

cso30:i:ME_Binding

cso30:i:CC_EndosomeMembrane

--

e79 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c273 : 1
stoichiometry:c274 : 1
stoichiometry:c275 : 1

m86*m89*0.1

nodelay

--

true

0

false

PMID: 17827709,16644730 In fact, MyD88 associates with p85 in response to flagellin and LPS

Go back
426.0, 626.0
19.0, 19.0

p92

p92

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016625 MO000000030 MO000000213

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c276 : 1
stoichiometry:c277 : 1
stoichiometry:c279 : 1
stoichiometry:c278 : 1

m1611*m27*m184*0.1

nodelay

--

true

0

false

PMID: 17827709,12516562 It is reported that IL-1b -, IL-18-, and LPS-induced activation of PI3K is diminished in IRAK-1 deficient cells.

Go back
426.0, 694.0
19.0, 19.0

p92

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016597 MO000000213 MO000000030

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c281 : 1
stoichiometry:c282 : 1
stoichiometry:c283 : 1

m1591*m184*m27*0.1

nodelay

--

true

0

false

PMID: 17827709,12516562 It is reported that IL-1b -, IL-18-, and LPS-induced activation of PI3K is diminished in IRAK-1 deficient cells.

Go back
1038.0, 510.0
19.0, 19.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e84 e79

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c285 : 1
stoichiometry:c286 : 1
stoichiometry:c287 : 1

m91*m86*0.1

nodelay

--

true

0

false

--

Go back
481.0, 609.0
21.0, 21.0

p95

p95

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e85 MO000000030

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c289 : 1
stoichiometry:c290 : 1

m93*m27*0.1

nodelay

--

true

0

false

PMID: 17827709 Several reports indicate that p85 binds the receptor itself to activate PI3K.

Go back
418.0, 516.0
23.0, 23.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e25 e79

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c291 : 1
stoichiometry:c292 : 1
stoichiometry:c293 : 1

m26*m86*0.1

nodelay

--

true

0

false

PMID: 17827709,11101877 For example, TLR2 is tyrosine-phosphorylated within the YXXM motif of its TIR domain and directly binds p85.

Go back
1176.0, 534.0
19.0, 19.0

p97

p97

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e79 MO000041437

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c294 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1

m86*m19305*0.1

nodelay

--

true

0

false

PMID: 17827709 Upon TLR3 stimulation, another adaptor, TICAM1/TRIF, may act in the recruitment of p85.

Go back
998.0, 1086.0
19.0, 19.0

p98

p98

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000017257 MO000041125

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c298 : 1
stoichiometry:c299 : 1

m2113*m18998*0.1

nodelay

--

true

0

false

PMID: 17827709,10868937 The association of the catalytically active form of p110a (p110aCAAT) with TRIF has been reported when both are transfected into 293T cells

Go back
740.0, 1110.0
19.0, 19.0

p99

p99

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000065 e79

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c300 : 1
stoichiometry:c301 : 1
stoichiometry:c302 : 1

m97*m86*0.1

nodelay

--

true

0

false

PMID: 17827709,15280422 RIP1 is another candidate for the adaptor of p85 in TLR signaling, since neither LPS nor CpG activates Akt in cells lacking RIP1.

Go back
458.0, 40.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
526.0, 124.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
355.1675379317294, 120.10709028295291

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
338.0, 119.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 324.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.7132238924518, 330.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 186.7210886532355

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
890.4388115967612, 100.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.0, 121.01372122536563

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.9884275257881, 301.43014609754243

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 314.49759883100864

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1030.0, 263.7201327147385

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
213.0, 444.0

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1082.9536563805268, 239.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.7653125695068, 223.92351779244666

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.0, 270.4354391016665

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1030.8972333385193, 343.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 341.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 381.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.9382230137094, 433.9922778767137

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.0, 415.4632633294639

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.9195959492894, 398.1313708498985

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 355.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
635.0, 359.65685424949237

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.0, 368.11773585424936

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.9897649086508, 356.40454505866586

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.4563983243081, 372.98697067539183

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.0, 365.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.0, 268.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.7772361026349, 284.80009178378634

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.0, 269.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.410363207638, 491.01438503361544

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 329.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.0, 486.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.8976891728458, 354.05239238904693

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.1901469178283, 196.91097657144704

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 184.9946523793667

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.1159660434203, 189.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 373.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
504.0, 410.7824545836682

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 414.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.4361230702536, 120.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
483.90327750435426, 385.94884203831776

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 376.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.104261780739, 252.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
682.0, 346.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.0, 360.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.7798505802838, 442.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.217063861271, 568.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
457.0, 678.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.0, 1238.364331469646

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
393.0, 462.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.96450270976106, 466.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
401.0, 493.8308170454446

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 494.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.8595779966347, 475.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.0, 124.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
490.0, 508.3104923889621

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 496.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.4512399668456, 479.73090930902015

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.0, 484.36019183191667

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
657.0, 477.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 595.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.0, 610.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 613.5298221281347

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.0, 594.4726885787005

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
922.5334722010213, 617.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.0, 702.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.9886464374226, 688.4260611433292

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
795.849491276741, 697.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
715.9738323849174, 809.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
648.6058387158519, 800.4801647986474

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
337.17609687796175, 479.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
325.40905094349677, 571.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 630.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
338.958950698325, 673.8093848167788

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.6377768816001, 481.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.0, 681.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 741.7788906005231

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.0, 745.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.0, 813.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 805.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.0, 727.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
327.0, 787.9160574934735

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 781.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 745.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.74672566954445, 916.9650738084744

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.0, 905.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
313.57523962958606, 727.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
874.0, 741.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
326.9382230137093, 977.9922778767136

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 1077.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.0, 1050.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.0, 1061.0220196095183

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 1082.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.0, 1144.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
381.60245808999866, 1151.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
466.08318322270355, 1210.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.0, 1245.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 1317.9921104517296

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 123.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
514.0, 1215.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.9195959492893, 1301.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.4906334205524, 1236.808987532707

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.0, 1208.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.8047565563683, 1237.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 728.8191776287172

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
917.0, 675.1174629007505

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 120.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 482.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.0, 424.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.0, 56.11617858220623

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
221.0, 443.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 116.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
979.7765111560652, 650.2519285685115

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.4774036933123, 649.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 482.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
531.0, 124.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.0, 1037.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 949.0

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.9376316715822, 785.996997214788

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 661.1859888263355

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
650.0, 792.1800254338474

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.3376393806831, 619.0

c21

c21

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
975.5350205109962, 754.687650628126

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.0, 752.9251818626557

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
968.0, 749.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.4964887808084, 820.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
594.0, 945.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
862.0, 1017.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 279.0

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
650.0, 737.697368716228

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
978.0, 658.3842323730722

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1050.0, 659.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.0, 942.4195757713

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 277.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.0, 660.0284148389046

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1054.0, 929.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 920.3459176274524

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.0, 281.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
535.0, 124.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
638.0, 676.7294278030124

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
798.0, 652.1595692457889

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.0, 821.4735616469734

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.0, 704.5058764309024

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 121.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
886.0, 698.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
990.0, 1003.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 943.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 124.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.0, 949.0

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.8296449231591, 236.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
750.0, 1060.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
650.0, 908.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.1076308227296, 236.0

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1204.4090509434968, 834.6286613210731

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 666.9496461483077

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.0, 787.0852294134236

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
939.0, 236.0

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
976.0, 768.7835479748409

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
578.0, 641.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 633.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 124.0

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
499.26265615675777, 124.0

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
426.0, 217.3711937189796

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.8996247238159, 221.0

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1139.0, 832.7688376822995

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.0, 226.92789561148786

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
196.0, 549.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.0, 276.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
485.0426707334486, 356.7948371427805

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.9077493033934, 354.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.11648241893243, 124.0

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.8049908093875, 299.5047326640743

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.02903021471184, 294.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.4904638506382, 226.0

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
699.0, 397.81219018771145

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1154.9895013078128, 813.4097180157853

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.9529959148782, 381.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.9973374380425, 464.0

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
708.0, 468.19747067807054

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.95523458058534, 421.8451288468982

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.4461836730202, 602.92478182223

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
602.230488890276, 482.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.4800172412391, 432.6914151972772

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.1877909388222, 587.5122160269245

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 124.0

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 535.795894993189

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.0, 957.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.4654160868197, 656.6106322680084

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 323.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 637.4563983243081

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.0, 571.9102312071875

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.6714357935462, 571.4944351276131

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 461.2170737730852

c275

c275

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
184.0, 636.1322133454933

c276

c276

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.75045466654274, 478.0

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.14677807293657, 439.35511983312887

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0343357322942, 449.0

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
894.0, 966.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.9934615576299, 672.0

c280

c280

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.45490256122764, 451.0

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.9475904024098, 481.0

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.46874783885806, 439.60955216212716

c283

c283

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0102733599996, 293.85435693963075

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1056.451643978432, 349.0

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.0, 536.9162638485062

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.0, 410.70465723063893

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.5267907233646, 392.0

c288

c288

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.4422256206635, 479.0

c289

c289

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.8547012599769, 819.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.75921353013797, 438.43038774682765

c290

c290

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 288.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.88368092595476, 531.3592553320611

c292

c292

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.18411291581737, 534.0

c293

c293

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1043.0, 553.9691115068547

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.0, 482.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1073.4782126851974, 423.83002450901733

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.0, 1112.99840047984

c297

c297

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 282.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.9919324320838, 1092.3591879744756

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.0, 50.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.2006560109219, 600.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
661.0, 1080.0

c300

c300

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0007503732919, 639.0

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
627.946105112698, 1121.0

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.0, 1150.1032554087665

c303

c303

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.0, 1150.0

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.0, 124.0

c305

c305

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
574.6154120165562, 1082.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.0, 1116.3094637505203

c307

c307

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 1110.0

c308

c308

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.91023416045516, 1077.0

c309

c309

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
694.0, 898.4897727614175

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.60444528432106, 236.0

c310

c310

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1206.0, 1079.0

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1145.0, 1136.0

c312

c312

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.6568542494924, 1145.0

c313

c313

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.0, 1315.7760861545617

c314

c314

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.0, 334.0

c315

c315

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.2394362184674, 1213.0

c316

c316

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
786.9901595273469, 1296.396674586464

c317

c317

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.5738142422746, 783.5635526414562

c318

c318

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
416.625971292066, 482.0

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.0, 896.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
347.30733935933034, 439.89245613225347

c320

c320

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.0, 181.4393360060571

c321

c321

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 177.55041673292303

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.0, 191.8362976331207

c323

c323

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.3266286671235, 193.9933293259951

c324

c324

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 187.31020551776967

c325

c325

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.2660627281394, 92.34728732419904

c326

c326

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 112.0

c327

c327

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.0, 836.8853789706903

c328

c328

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
370.0, 829.0

c329

c329

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.6510610367445, 816.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
367.54113068589436, 102.0

c330

c330

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 1001.319744306791

c331

c331

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.99232831848497, 927.7479434607748

c332

c332

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.0, 872.682769814029

c333

c333

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
511.0, 861.0

c334

c334

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.2397421507617, 852.9033562111058

c335

c335

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
483.0, 814.0978598748408

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.6568542494924, 215.65685424949237

c337

c337

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 189.0

c338

c338

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 211.250312299017

c339

c339

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
216.0, 444.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.0, 206.949005762265

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 217.996864798398

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 204.0

c342

c342

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
335.0, 836.465735408528

c343

c343

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.0, 829.0

c344

c344

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.48516703280825, 351.0

c345

c345

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
555.5763351556541, 381.5688802247672

c346

c346

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
555.2888633827068, 353.0

c347

c347

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 386.0

c348

c348

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.8979289657012, 678.2738595105969

c349

c349

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.9061873786675, 814.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
931.7790984158441, 678.0

c350

c350

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.0, 549.0

c351

c351

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0, 117.0

c352

c352

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 861.8312961731278

c353

c353

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1014.0, 765.7747199707156

c354

c354

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 124.0

c355

c355

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.1363107415758, 289.0

c356

c356

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
665.8542388047223, 592.0

c357

c357

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
215.0, 444.0

c358

c358

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.0, 124.0

c359

c359

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
898.1981184904287, 600.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
606.0, 730.0

c360

c360

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.0, 706.0

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 855.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 855.6447679879159

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
974.0, 864.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.975696675207, 122.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.7074115601451, 815.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
220.0, 444.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.9555031218467, 546.3415337278419

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.7487994142166, 434.98899664108234

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.913627698831, 534.1723892887157

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
221.0, 438.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
854.5193955741213, 611.6365376465773

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.40255085328727, 440.03351955070275

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 1182.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.3969320118102, 1146.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.0, 370.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 1206.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 1180.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 1183.7923303927898

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
627.0, 1186.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.0, 1136.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 1136.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 1147.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 124.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.796029752168, 252.9602975216799

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 131.31934241258347

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
221.0, 366.9624662734139

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.0, 244.98228126285287

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 113.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
663.0, 115.98812566344756

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1103.0, 476.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.0, 479.18672362344194

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.9541490951063, 465.85528484893615

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.9284852929829, 465.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.0, 282.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 480.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 107.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.0, 482.0

c7

c7

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
782.714609183337, 189.11773585424936

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.0, 134.9551113054329

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 250.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 316.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 280.70798021359997

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 272.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.8560515758452, 275.51077914920097

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.1006753912829, 229.68516064610884

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 242.64280339782485

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.86265596863234, 239.47602205909342

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.6568542494924, 719.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.61698946997717, 180.49615951165117

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.3914313453247, 127.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.0, 220.77037849305577

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
867.0, 332.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 317.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 321.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 316.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 309.7705935588815

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.7947635052911, 228.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 117.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.4563983243081, 718.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
703.4590126927371, 176.98682085362543

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
711.0, 109.44174945651814

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.9675012930073, 114.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 188.9910868999312

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.0, 100.0524843406346

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
273.0, 206.04156351879809

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
399.3027748699074, 211.26641687471897

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.3836643867279, 129.82170395167745

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.58138769882385, 187.5481134504067

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.0, 121.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back