_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e3
_enti_e2
_enti_e4
_enti_e20
_enti_e55
_enti_e21
_enti_e19
_enti_e59
_enti_e53
_enti_e56
_enti_e52
_enti_e51
_enti_e54
_enti_e50
_enti_e61
_enti_e58
_enti_e57
_enti_e60
_enti_e62
g1_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
g1_fact_g14
p1_propro_p1
PMID: 17827709,9398628
Prior to the discovery of TLR, wortmannin was reported
to enhance LPS-induced NO production in macrophages
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17827709,9398628
Prior to the discovery of TLR, wortmannin was reported to enhance LPS-induced NO production in macrophages
c4 cso30:c:InputAssociation connector
c6 cso30:c:InputAssociation connector
c5 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 17827709,10229863
The role of PI3K in this regulation was confirmed by the
finding that a dominant negative mutant of PI3K (p110DN)
increased, while a constitutively active form of PI3K
(p110CAAT) suppressed the expression of inducible NO synthase
(iNOS).
c7 cso30:c:InputInhibitor connector
c8 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 17827709,12072439
The induction of cyclooxygenase
by LPS is enhanced in the presence of wortmannin
c10 cso30:c:InputAssociation connector
c11 cso30:c:InputAssociation connector
c9 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 17827709
SHIP is a lipid phosphatase that metabolizes PtdIns-3,4,5-
P3 (PIP3) to produce PtdIns-3,4-P
c12 cso30:c:InputAssociation connector
c13 cso30:c:InputProcess connector
c14 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 17827709,9794431
The activation of a receptor tyrosine kinase, RON, inhibits
the LPS-induced expression of iNOS in murine peritoneal
macrophages; this inhibition is recovered by wortmannin administration.
PMID: 17827709,10868937
In b -pancreatic cells, LPS induces
the expression of iNOS, which is abrogated by insulinlike
growth factor-1 (IGF-1)
PMID: 17827709
The effect of IGF-1 is inhibited
by wortmannin, LY294002, and the overexpression of
Dp85.
c15 cso30:c:InputAssociation connector
c21 cso30:c:InputInhibitor connector
c356 cso30:c:InputInhibitor connector
c16 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 17827709,10066820
In C6 glial cells, LPS or wortmannin alone has no effect,
but their combination induces iNOS production
c17 cso30:c:InputAssociation connector
c19 cso30:c:InputAssociation connector
c20 cso30:c:InputAssociation connector
c18 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17827709,16670329
In epithelial cells, flagellin-induced (TLR5-mediated)
production of NO, IL-6, and IL-8 was increased in the presence
of wortmannin or LY294002
c24 cso30:c:InputProcess connector
c25 cso30:c:InputProcess connector
c26 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 17827709,16670329
In epithelial cells, flagellin-induced (TLR5-mediated)
production of NO, IL-6, and IL-8 was increased in the presence
of wortmannin or LY294002
c27 cso30:c:InputAssociation connector
c29 cso30:c:InputAssociation connector
c30 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
p9_propro_p10
PMID: 17827709,16670329
In epithelial cells, flagellin-induced (TLR5-mediated)
production of NO, IL-6, and IL-8 was increased in the presence
of wortmannin or LY294002
c31 cso30:c:InputAssociation connector
c33 cso30:c:InputAssociation connector
c34 cso30:c:InputAssociation connector
c32 cso30:c:OutputProcess connector
p9_propro_p11
PMID: 17827709,16670329
In epithelial cells, flagellin-induced (TLR5-mediated)
production of NO, IL-6, and IL-8 was increased in the presence
of wortmannin or LY294002
c35 cso30:c:InputAssociation connector
c36 cso30:c:InputAssociation connector
c38 cso30:c:InputAssociation connector
c37 cso30:c:OutputProcess connector
p9_propro_p12
PMID: 17827709,16670329
In epithelial cells, flagellin-induced (TLR5-mediated)
production of NO, IL-6, and IL-8 was increased in the presence
of wortmannin or LY294002
c40 cso30:c:InputAssociation connector
c41 cso30:c:InputAssociation connector
c353 cso30:c:InputAssociation connector
c39 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17827709,16670329
In epithelial cells, flagellin-induced (TLR5-mediated)
production of NO, IL-6, and IL-8 was increased in the presence
of wortmannin or LY294002
c42 cso30:c:InputAssociation connector
c44 cso30:c:InputAssociation connector
c43 cso30:c:OutputProcess connector
p13_propro_p14
PMID: 17827709,16670329
In epithelial cells, flagellin-induced (TLR5-mediated)
production of NO, IL-6, and IL-8 was increased in the presence
of wortmannin or LY294002
c45 cso30:c:InputAssociation connector
c46 cso30:c:InputAssociation connector
c47 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17827709
GSK-3 can differentially regulate the
production of pro-inflammatory and anti-inflammatory cytokines
by affecting the relative amounts of active transcription
factors, CREB and the p65 subunit of NF-k B, that interact
with a common coactivator CBP (CREB-binding protein).
c48 cso30:c:InputProcess connector
c49 cso30:c:InputProcess connector
c50 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17827709,16007092
Since GSK-3 inactivates CREB, the inhibition of GSK-
3 augments the binding of CREB to CBP and competitively
suppresses the binding of NF-k B p65 to the coactivator
c51 cso30:c:InputProcess connector
c52 cso30:c:InputAssociation connector
c53 cso30:c:OutputProcess connector
p15_propro_p17
PMID: 17827709
GSK-3 can differentially regulate the
production of pro-inflammatory and anti-inflammatory cytokines
by affecting the relative amounts of active transcription
factors, CREB and the p65 subunit of NF-k B, that interact
with a common coactivator CBP (CREB-binding protein).
PMID: 17827709,16007092
Since GSK-3 inactivates CREB, the inhibition of GSK-
3 augments the binding of CREB to CBP and competitively
suppresses the binding of NF-k B p65 to the coactivator
c54 cso30:c:InputProcess connector
c55 cso30:c:InputProcess connector
c56 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c57 cso30:c:InputProcess connector
c58 cso30:c:InputProcess connector
c59 cso30:c:OutputProcess connector
p18_propro_p19
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c60 cso30:c:InputProcess connector
c61 cso30:c:InputProcess connector
c62 cso30:c:OutputProcess connector
p18_propro_p20
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c63 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p18_propro_p21
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c66 cso30:c:InputProcess connector
c67 cso30:c:InputProcess connector
c68 cso30:c:OutputProcess connector
p18_propro_p22
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c69 cso30:c:InputProcess connector
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
p18_propro_p23
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c72 cso30:c:InputProcess connector
c73 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p18_propro_p24
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c75 cso30:c:InputProcess connector
c76 cso30:c:InputProcess connector
c77 cso30:c:OutputProcess connector
p18_propro_p25
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c78 cso30:c:InputProcess connector
c79 cso30:c:InputProcess connector
c80 cso30:c:OutputProcess connector
p18_propro_p26
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c81 cso30:c:InputProcess connector
c82 cso30:c:InputProcess connector
c321 cso30:c:OutputProcess connector
p18_propro_p27
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c83 cso30:c:InputProcess connector
c84 cso30:c:InputProcess connector
p18_propro_p28
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c86 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c87 cso30:c:OutputProcess connector
p29_propro_p29
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c89 cso30:c:InputProcess connector
c90 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p29_propro_p31
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c92 cso30:c:InputProcess connector
c93 cso30:c:InputProcess connector
c94 cso30:c:OutputProcess connector
p29_propro_p30
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c95 cso30:c:InputProcess connector
c96 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p29_propro_p32
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c98 cso30:c:InputProcess connector
c99 cso30:c:InputProcess connector
c100 cso30:c:OutputProcess connector
p29_propro_p33
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c101 cso30:c:InputProcess connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p29_propro_p34
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c104 cso30:c:InputProcess connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p29_propro_p35
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c108 cso30:c:InputProcess connector
c107 cso30:c:InputProcess connector
c112 cso30:c:OutputProcess connector
p18_propro_p36
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c109 cso30:c:InputProcess connector
c110 cso30:c:InputProcess connector
c111 cso30:c:OutputProcess connector
p18_propro_p37
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c113 cso30:c:InputProcess connector
c114 cso30:c:InputProcess connector
c115 cso30:c:OutputProcess connector
p18_propro_p38
PMID: 17827709,14698224,12539043,14519765,14556004
MyD88 is shared by all TLRs except TLR3,
while TIRAP/Mal only binds to TLR2 and TLR4,TICAM-
1/TRIF binds exclusively to TLR3 and TLR4,and
TICAM-2/TRAM binds only to TLR4.
c85 cso30:c:InputProcess connector
c116 cso30:c:InputProcess connector
c117 cso30:c:OutputProcess connector
p29_propro_p39
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c118 cso30:c:InputProcess connector
c119 cso30:c:InputProcess connector
c120 cso30:c:OutputProcess connector
p29_propro_p40
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c121 cso30:c:InputProcess connector
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
p29_propro_p41
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c124 cso30:c:InputProcess connector
c125 cso30:c:InputProcess connector
c126 cso30:c:OutputProcess connector
p29_propro_p42
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c127 cso30:c:InputProcess connector
c128 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p29_propro_p43
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c130 cso30:c:InputProcess connector
c131 cso30:c:InputProcess connector
c132 cso30:c:OutputProcess connector
p44_propro_p44
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c133 cso30:c:InputAssociation connector
c134 cso30:c:InputProcess connector
c135 cso30:c:OutputProcess connector
p44_propro_p45
PMID:17827709,9430229,12620219,10882101
MyD88 recruits IRAKs
(IRAK1 and 4) to TLRs and allows IRAK1 to bind
TRAF6, a key event leading to the activation of TAK1.
c136 cso30:c:InputAssociation connector
c137 cso30:c:InputProcess connector
c138 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 17827709,11460167
TAK1 activates the IKK complex consisting of IKKa , IKKb ,
and NEMO/IKKg
c145 cso30:c:InputProcess connector
c146 cso30:c:InputProcess connector
c147 cso30:c:InputProcess connector
c148 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 17827709,11460167
TAK1 activates the IKK complex consisting of IKKa , IKKb ,
and NEMO/IKKg
c149 cso30:c:InputAssociation connector
c150 cso30:c:InputProcess connector
c151 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 17827709
The activated IKK complex phosphorylates
Ik B leading to its ubiquitination
c152 cso30:c:InputProcess connector
c153 cso30:c:InputAssociation connector
c154 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 17827709
The activated IKK complex phosphorylates
Ik B leading to its ubiquitination
c155 cso30:c:InputProcess connector
c156 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 17827709
The resultant degradation
of Ik B enables the bound NF-k B to translocate into the
nucleus and to induce the expression of inflammatory cytokines.
c157 cso30:c:InputProcess connector
c158 cso30:c:OutputProcess connector
c159 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 17827709
The resultant degradation
of Ik B enables the bound NF-k B to translocate into the
nucleus and to induce the expression of inflammatory cytokines.
c160 cso30:c:InputProcess connector
c161 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 17827709
The resultant degradation
of Ik B enables the bound NF-k B to translocate into the
nucleus and to induce the expression of inflammatory cytokines.
c162 cso30:c:InputAssociation connector
c163 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 17827709,11460167
TAK1
has the ability to act as a MAPK kinase kinase and is known
to activate MAPK kinases, including MKK3/6, which in turn
activate p38MAPK and SAPK/JNK.
c164 cso30:c:InputAssociation connector
c165 cso30:c:InputProcess connector
c166 cso30:c:OutputProcess connector
p55_propro_p56
PMID: 17827709,11460167
TAK1
has the ability to act as a MAPK kinase kinase and is known
to activate MAPK kinases, including MKK3/6, which in turn
activate p38MAPK and SAPK/JNK.
c167 cso30:c:InputProcess connector
c168 cso30:c:InputAssociation connector
c169 cso30:c:OutputProcess connector
p55_propro_p57
PMID: 17827709,11460167
TAK1
has the ability to act as a MAPK kinase kinase and is known
to activate MAPK kinases, including MKK3/6, which in turn
activate p38MAPK and SAPK/JNK.
c170 cso30:c:InputAssociation connector
c171 cso30:c:InputProcess connector
c172 cso30:c:OutputProcess connector
p55_propro_p58
PMID: 17827709,11460167
TAK1
has the ability to act as a MAPK kinase kinase and is known
to activate MAPK kinases, including MKK3/6, which in turn
activate p38MAPK and SAPK/JNK.
c173 cso30:c:InputAssociation connector
c174 cso30:c:InputProcess connector
c175 cso30:c:OutputProcess connector
p55_propro_p59
PMID: 17827709,11460167
TAK1
has the ability to act as a MAPK kinase kinase and is known
to activate MAPK kinases, including MKK3/6, which in turn
activate p38MAPK and SAPK/JNK.
c176 cso30:c:InputAssociation connector
c177 cso30:c:InputProcess connector
c178 cso30:c:OutputProcess connector
p55_propro_p60
PMID: 17827709,11460167
TAK1
has the ability to act as a MAPK kinase kinase and is known
to activate MAPK kinases, including MKK3/6, which in turn
activate p38MAPK and SAPK/JNK.
c179 cso30:c:InputAssociation connector
c180 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 17827709,15372110
Another MAPK kinase kinase,
Cot/Tpl2, which phosphorylates MEK1/2, is also activated
downstream of TLR, although the mechanism is yet unknown.
c181 cso30:c:InputAssociation connector
c182 cso30:c:InputProcess connector
c183 cso30:c:OutputProcess connector
p61_propro_p62
PMID: 17827709,15372110
Another MAPK kinase kinase,
Cot/Tpl2, which phosphorylates MEK1/2, is also activated
downstream of TLR, although the mechanism is yet unknown.
c184 cso30:c:InputAssociation connector
c185 cso30:c:InputProcess connector
c186 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 17827709,15361868
Formation of a signaling complex consisting
of MyD88, IRAKs, and TRAF6 induces the phosphorylation
of IRF7 by IRAK-1 and allows the nuclear translocation
of this transcription factor
c139 cso30:c:InputAssociation connector
c140 cso30:c:InputProcess connector
c141 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 17827709,15361868
Formation of a signaling complex consisting
of MyD88, IRAKs, and TRAF6 induces the phosphorylation
of IRF7 by IRAK-1 and allows the nuclear translocation
of this transcription factor
c142 cso30:c:InputProcess connector
c143 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 17827709,11035810,11884598
In
addition to Akt, several other protein kinases, including
cyclic AMP-dependent kinase and certain PKCs, are known
to phosphorylate the inhibitory N-terminal site of GSK-
3.
c144 cso30:c:InputAssociation connector
c187 cso30:c:InputProcess connector
c188 cso30:c:OutputProcess connector
p63_propro_p64
PMID: 17827709,11035810,11884598
In
addition to Akt, several other protein kinases, including
cyclic AMP-dependent kinase and certain PKCs, are known
to phosphorylate the inhibitory N-terminal site of GSK-
3.
c189 cso30:c:InputAssociation connector
c190 cso30:c:InputProcess connector
c191 cso30:c:OutputProcess connector
p63_propro_p65
PMID: 17827709,11035810,11884598
In
addition to Akt, several other protein kinases, including
cyclic AMP-dependent kinase and certain PKCs, are known
to phosphorylate the inhibitory N-terminal site of GSK-
3.
c192 cso30:c:InputAssociation connector
c193 cso30:c:InputProcess connector
c194 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 17827709,11714830
In lung neutrophils, LPS-induced activation
of NF-k B and the production of IL-1b and TNF-a are
inhibited by PI3K inhibition.
c195 cso30:c:InputAssociation connector
c197 cso30:c:InputAssociation connector
c198 cso30:c:InputAssociation connector
c196 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 17827709,11714830
In lung neutrophils, LPS-induced activation
of NF-k B and the production of IL-1b and TNF-a are
inhibited by PI3K inhibition.
PMID: 17827709,12052830
In human monocytic THP1 cells, as well as
in human peripheral blood monocytes, inhibitors of PI3K and
a dominant negative Akt enhance the LPS-induced activation
of AP-1, Egr-1, and NF-k B, which results in increased production
of TNF-a
c200 cso30:c:InputAssociation connector
c201 cso30:c:InputProcess connector
c199 cso30:c:InputAssociation connector
c202 cso30:c:OutputProcess connector
p66_propro_p68
PMID: 17827709,11714830
In lung neutrophils, LPS-induced activation
of NF-k B and the production of IL-1b and TNF-a are
inhibited by PI3K inhibition.
c203 cso30:c:InputAssociation connector
c204 cso30:c:InputAssociation connector
c206 cso30:c:InputAssociation connector
c205 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
Was found to be increases in p85 knockout
mice.
c207 cso30:c:InputAssociation connector
c209 cso30:c:InputAssociation connector
c208 cso30:c:OutputProcess connector
p69_propro_p70
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
Was found to be increases in Dcs obtained from p85 knockout
mice.
c210 cso30:c:InputAssociation connector
c211 cso30:c:InputAssociation connector
c212 cso30:c:OutputProcess connector
p69_propro_p71
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
Was found to be increases in Dcs obtained from p85 knockout
mice.
c213 cso30:c:InputAssociation connector
c214 cso30:c:InputAssociation connector
c215 cso30:c:OutputProcess connector
p69_propro_p72
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c216 cso30:c:InputAssociation connector
c217 cso30:c:InputAssociation connector
c218 cso30:c:OutputProcess connector
p69_propro_p73
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c220 cso30:c:InputAssociation connector
c221 cso30:c:InputAssociation connector
c219 cso30:c:OutputProcess connector
p69_propro_p74
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c223 cso30:c:InputAssociation connector
c224 cso30:c:InputAssociation connector
c222 cso30:c:OutputProcess connector
p69_propro_p75
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c225 cso30:c:InputAssociation connector
c226 cso30:c:InputAssociation connector
c227 cso30:c:OutputProcess connector
p69_propro_p76
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c228 cso30:c:InputAssociation connector
c242 cso30:c:InputAssociation connector
c243 cso30:c:OutputProcess connector
p69_propro_p77
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c229 cso30:c:InputAssociation connector
c230 cso30:c:InputAssociation connector
c231 cso30:c:OutputProcess connector
p69_propro_p78
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
Was found to be increases in Dcs obtained from p85 knockout
mice.
c233 cso30:c:InputAssociation connector
c234 cso30:c:InputAssociation connector
c232 cso30:c:OutputProcess connector
p69_propro_p79
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
Was found to be increases in Dcs obtained from p85 knockout
mice.
c235 cso30:c:InputAssociation connector
c236 cso30:c:InputAssociation connector
c237 cso30:c:OutputProcess connector
p69_propro_p80
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c238 cso30:c:InputAssociation connector
c239 cso30:c:InputAssociation connector
c240 cso30:c:OutputProcess connector
p69_propro_p81
PMID: 17827709,9261174
In addition, TLR2-, TLR4-, TLR5-,
and TLR9-mediated production of IL-12, IFN-g , and TNF-a
was found to be increases in Dcs obtained from p85 knockout
mice.
c241 cso30:c:InputAssociation connector
c354 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 17827709,12052830
In human monocytic THP1 cells, as well as
in human peripheral blood monocytes, inhibitors of PI3K and
a dominant negative Akt enhance the LPS-induced activation
of AP-1, Egr-1, and NF-k B, which results in increased production
of TNF-a
c244 cso30:c:InputProcess connector
c246 cso30:c:InputAssociation connector
c251 cso30:c:InputAssociation connector
c245 cso30:c:OutputProcess connector
p82_propro_p83
PMID: 17827709,12052830
In human monocytic THP1 cells, as well as
in human peripheral blood monocytes, inhibitors of PI3K and
a dominant negative Akt enhance the LPS-induced activation
of AP-1, Egr-1, and NF-k B, which results in increased production
of TNF-a
c247 cso30:c:InputAssociation connector
c248 cso30:c:InputProcess connector
c250 cso30:c:InputAssociation connector
c249 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 17827709
It was shown that most TLRs, including
at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate
PI3K.
c252 cso30:c:InputAssociation connector
c253 cso30:c:InputProcess connector
c254 cso30:c:OutputProcess connector
p84_propro_p85
PMID: 17827709
It was shown that most TLRs, including
at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate
PI3K.
PMID: 17827709,12516562
It is
reported that IL-1b -, IL-18-, and LPS-induced activation
of PI3K is diminished in IRAK-1 deficient cells.
c255 cso30:c:InputAssociation connector
c256 cso30:c:InputProcess connector
c284 cso30:c:InputAssociation connector
c257 cso30:c:OutputProcess connector
p84_propro_p86
PMID: 17827709
It was shown that most TLRs, including
at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate
PI3K.
c258 cso30:c:InputAssociation connector
c259 cso30:c:InputProcess connector
c260 cso30:c:OutputProcess connector
p84_propro_p87
PMID: 17827709
It was shown that most TLRs, including
at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate
PI3K.
c261 cso30:c:InputAssociation connector
c262 cso30:c:InputProcess connector
c263 cso30:c:OutputProcess connector
p84_propro_p88
PMID: 17827709
It was shown that most TLRs, including
at least TLR2, TLR3, TLR4, TLR5, and TLR9, activate
PI3K.
c264 cso30:c:InputAssociation connector
c265 cso30:c:InputProcess connector
c266 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 17827709,16644730
In fact, MyD88 associates with p85 in response to
flagellin and LPS
c267 cso30:c:InputProcess connector
c268 cso30:c:InputProcess connector
c269 cso30:c:OutputProcess connector
p89_propro_p90
PMID: 17827709,16644730
In fact, MyD88 associates with p85 in response to
flagellin and LPS
c270 cso30:c:InputProcess connector
c271 cso30:c:InputProcess connector
c272 cso30:c:OutputProcess connector
p89_propro_p91
PMID: 17827709,16644730
In fact, MyD88 associates with p85 in response to
flagellin and LPS
c273 cso30:c:InputProcess connector
c274 cso30:c:InputProcess connector
c275 cso30:c:OutputProcess connector
p92_propro_p92
PMID: 17827709,12516562
It is
reported that IL-1b -, IL-18-, and LPS-induced activation
of PI3K is diminished in IRAK-1 deficient cells.
c276 cso30:c:InputAssociation connector
c277 cso30:c:InputProcess connector
c279 cso30:c:InputAssociation connector
c278 cso30:c:OutputProcess connector
p92_propro_p93
PMID: 17827709,12516562
It is
reported that IL-1b -, IL-18-, and LPS-induced activation
of PI3K is diminished in IRAK-1 deficient cells.
c280 cso30:c:InputAssociation connector
c281 cso30:c:InputAssociation connector
c282 cso30:c:InputProcess connector
c283 cso30:c:OutputProcess connector
p94_propro_p94
c285 cso30:c:InputProcess connector
c286 cso30:c:InputProcess connector
c287 cso30:c:OutputProcess connector
p95_propro_p95
PMID: 17827709
Several reports indicate that p85 binds
the receptor itself to activate PI3K.
c288 cso30:c:InputAssociation connector
c289 cso30:c:InputProcess connector
c290 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 17827709,11101877
For example, TLR2 is
tyrosine-phosphorylated within the YXXM motif of its TIR
domain and directly binds p85.
c291 cso30:c:InputProcess connector
c292 cso30:c:InputProcess connector
c293 cso30:c:OutputProcess connector
p97_propro_p97
PMID: 17827709
Upon TLR3 stimulation, another adaptor, TICAM1/TRIF,
may act in the recruitment of p85.
c294 cso30:c:InputProcess connector
c295 cso30:c:InputProcess connector
c296 cso30:c:OutputProcess connector
p98_propro_p98
PMID: 17827709,10868937
The association of the catalytically
active form of p110a (p110aCAAT) with TRIF
has been reported when both are transfected into 293T
cells
c297 cso30:c:InputProcess connector
c298 cso30:c:InputProcess connector
c299 cso30:c:OutputProcess connector
p99_propro_p99
PMID: 17827709,15280422
RIP1 is another candidate for the adaptor of p85 in
TLR signaling, since neither LPS nor CpG activates Akt in cells lacking RIP1.
c300 cso30:c:InputProcess connector
c301 cso30:c:InputProcess connector
c302 cso30:c:OutputProcess connector
p100_propro_p100
PMID: 17827709,15280422
RIP1 is another candidate for the adaptor of p85 in
TLR signaling, since neither LPS nor CpG activates Akt in cells lacking RIP1.
c303 cso30:c:InputProcess connector
c305 cso30:c:InputAssociation connector
c306 cso30:c:InputAssociation connector
c304 cso30:c:OutputProcess connector
p100_propro_p101
PMID: 17827709,15280422
RIP1 is another candidate for the adaptor of p85 in
TLR signaling, since neither LPS nor CpG activates Akt in cells lacking RIP1.
c307 cso30:c:InputProcess connector
c309 cso30:c:InputAssociation connector
c310 cso30:c:InputAssociation connector
c308 cso30:c:OutputProcess connector
p102_propro_p102
c311 cso30:c:InputProcess connector
c312 cso30:c:InputProcess connector
c313 cso30:c:OutputProcess connector
p103_propro_p103
PMID: 17827709,10635328
Stimulation of TNF receptors induces the binding of
TRAF6 to Src-family tyrosine kinases to activate PI3K.
c314 cso30:c:InputProcess connector
c315 cso30:c:InputProcess connector
c316 cso30:c:InputAssociation connector
c317 cso30:c:OutputProcess connector
p104_propro_p104
PMID: 17827709,10635328
Stimulation of TNF receptors induces the binding of
TRAF6 to Src-family tyrosine kinases to activate PI3K.
c318 cso30:c:InputAssociation connector
c319 cso30:c:InputProcess connector
c320 cso30:c:OutputProcess connector
p105_propro_p105
PMID: 17827709
This pathway
requires a TIR domain-containing adaptor TICAM1/TRIF
that interacts with TBK1, IKKi, RIP1, and TRAF6.
c322 cso30:c:InputProcess connector
c323 cso30:c:InputProcess connector
c324 cso30:c:InputProcess connector
c325 cso30:c:InputProcess connector
c327 cso30:c:InputProcess connector
c326 cso30:c:OutputProcess connector
p107_propro_p107
PMID: 17827709
The nuclear
translocation of IRF3 is triggered by phosphorylation
with TBK1 and IKKi.
c328 cso30:c:InputProcess connector
c330 cso30:c:InputAssociation connector
c329 cso30:c:OutputProcess connector
p108_propro_p108
PMID: 17827709
The nuclear
translocation of IRF3 is triggered by phosphorylation
with TBK1 and IKKi.
c331 cso30:c:InputProcess connector
c332 cso30:c:OutputProcess connector
p109_propro_p109
PMID: 17827709
Treatment of
macrophages and dendritic cells (DCs) with dsRNA or LPS
results in IRF3 activation, which leads to the expression of
IFN-b and the IFN-inducible gene products.
c333 cso30:c:InputAssociation connector
c334 cso30:c:OutputProcess connector
p109_propro_p110
PMID: 17827709
Treatment of
macrophages and dendritic cells (DCs) with dsRNA or LPS
results in IRF3 activation, which leads to the expression of
IFN-b and the IFN-inducible gene products.
c335 cso30:c:InputAssociation connector
c336 cso30:c:OutputProcess connector
p105_propro_p111
PMID: 17827709
This pathway
requires a TIR domain-containing adaptor TICAM1/TRIF
that interacts with TBK1, IKKi, RIP1, and TRAF6.
c337 cso30:c:InputProcess connector
c338 cso30:c:InputProcess connector
c339 cso30:c:InputProcess connector
c340 cso30:c:InputProcess connector
c341 cso30:c:InputProcess connector
c342 cso30:c:OutputProcess connector
p107_propro_p112
PMID: 17827709
The nuclear
translocation of IRF3 is triggered by phosphorylation
with TBK1 and IKKi.
c343 cso30:c:InputProcess connector
c345 cso30:c:InputAssociation connector
c344 cso30:c:OutputProcess connector
p46_propro_p113
PMID: 17827709,15361868
Formation of a signaling complex consisting
of MyD88, IRAKs, and TRAF6 induces the phosphorylation
of IRF7 by IRAK-1 and allows the nuclear translocation
of this transcription factor
c346 cso30:c:InputAssociation connector
c347 cso30:c:InputProcess connector
c348 cso30:c:OutputProcess connector
p67_propro_p114
PMID: 17827709,11714830
In lung neutrophils, LPS-induced activation
of NF-k B and the production of IL-1b and TNF-a are
inhibited by PI3K inhibition.
PMID: 17827709,12052830
In human monocytic THP1 cells, as well as
in human peripheral blood monocytes, inhibitors of PI3K and
a dominant negative Akt enhance the LPS-induced activation
of AP-1, Egr-1, and NF-k B, which results in increased production
of TNF-a
c349 cso30:c:InputProcess connector
c351 cso30:c:InputAssociation connector
c352 cso30:c:InputAssociation connector
c350 cso30:c:OutputProcess connector
p6_propro_p106
PMID: 17827709,9794431
The activation of a receptor tyrosine kinase, RON, inhibits
the LPS-induced expression of iNOS in murine peritoneal
macrophages; this inhibition is recovered by wortmannin administration.
PMID: 17827709,10868937
In b -pancreatic cells, LPS induces
the expression of iNOS, which is abrogated by insulinlike
growth factor-1 (IGF-1)
PMID: 17827709
The effect of IGF-1 is inhibited
by wortmannin, LY294002, and the overexpression of
Dp85.
c355 cso30:c:InputAssociation connector
c358 cso30:c:InputAssociation connector
c360 cso30:c:OutputProcess connector
p6_propro_p115
PMID: 17827709,9794431
The activation of a receptor tyrosine kinase, RON, inhibits
the LPS-induced expression of iNOS in murine peritoneal
macrophages; this inhibition is recovered by wortmannin administration.
PMID: 17827709,10868937
In b -pancreatic cells, LPS induces
the expression of iNOS, which is abrogated by insulinlike
growth factor-1 (IGF-1)
PMID: 17827709
The effect of IGF-1 is inhibited
by wortmannin, LY294002, and the overexpression of
Dp85.
c357 cso30:c:InputAssociation connector
c359 cso30:c:InputAssociation connector
c361 cso30:c:OutputProcess connector
wortmannin_enti_e5
wortmannin
LPS_enti_MO000016882
LPS
TLR4_enti_MO000019394
TLR4
LPS:TLR4_enti_e6
LPS:TLR4
NO_enti_e11
NO
PI3K_enti_MO000000030
PI3K
iNOS_enti_G010514
iNOS
Cyclooxygenase_enti_e12
Cyclooxygenase
SHIP_enti_MO000017112
SHIP
PIP3_enti_MO000017272
PIP3
PIP2_enti_MO000000331
PIP2
iNOS_enti_MO000021201
iNOS
IGF-1_enti_MO000017094
IGF-1
LY294002_enti_e13
LY294002
flagellin_enti_MO000022185
flagellin
TLR5_enti_MO000019399
TLR5
TLR5:Flagellin_enti_e14
TLR5:Flagellin
IL-6_enti_MO000007384
IL-6
IL-6_enti_G010262
IL-6
IL-8_enti_MO000017264
IL-8
IL-8_enti_e15
IL-8
CBP_enti_MO000017462
CBP
CREB_enti_MO000099621
CREB
CREB:CBP_enti_e16
CREB:CBP
GSK3_enti_MO000016941
GSK3
CREB{inactive}_enti_e17
CREB{inactive}
NF-kappaB{active}_enti_MO000000058
NF-kappaB{active}
RelA-p65_enti_MO000080947
RelA-p65
p65:CBP_enti_e18
p65:CBP
MyD88_enti_MO000016573
MyD88
LPS:TLR4:MyD88_enti_e22
LPS:TLR4:MyD88
TIRAP_enti_MO000022528
TIRAP
TLR3_enti_MO000019398
TLR3
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
dsRNA:TLR3:TRIF_enti_MO000041437
dsRNA:TLR3:TRIF
TRIF_enti_MO000041125
TRIF
TRAM_enti_MO000041132
TRAM
dsRNA_enti_MO000022224
dsRNA
TLR7_enti_MO000042126
TLR7
TLR9_enti_MO000042012
TLR9
LPS:TLR4:TRAM_enti_e24
LPS:TLR4:TRAM
TLR2_enti_MO000019397
TLR2
PGN_enti_MO000042032
PGN
TLR2:PGN_enti_e25
TLR2:PGN
TLR2:PGN:MyD88_enti_e26
TLR2:PGN:MyD88
TLR2:PGN:MyD88:TIRAP_enti_e27
TLR2:PGN:MyD88:TIRAP
TLR7:ssRNA_enti_e28
TLR7:ssRNA
TLR9:CpGDNA_enti_e29
TLR9:CpGDNA
IRAK-4_enti_MO000039077
IRAK-4
LPS:TLR4:TIRAP_enti_e23
LPS:TLR4:TIRAP
IRAK_enti_MO000000213
IRAK
LPS:TLR4:MyD88:IRAK-4_enti_e30
LPS:TLR4:MyD88:IRAK-4
LPS:TLR4:MyD88:IRAK-4:IRAK1_enti_e31
LPS:TLR4:MyD88:IRAK-4:IRAK1
TLR2:PGN:MyD88:IRAK-4_enti_e32
TLR2:PGN:MyD88:IRAK-4
TLR2:PGN:MyD88:IRAK-4:IRAK1_enti_e33
TLR2:PGN:MyD88:IRAK-4:IRAK1
TRAF6_enti_MO000000212
TRAF6
TLR2:PGN:MyD88:IRAK-4:IRAK1:TRAF6_enti_e34
TLR2:PGN:MyD88:IRAK-4:IRAK1:TRAF6
LPS:TLR4:MyD88:IRAK-4:IRAK1:TRAF6_enti_e35
LPS:TLR4:MyD88:IRAK-4:IRAK1:TRAF6
ssRNA_enti_e37
ssRNA
TLR9:CpGDNA:MyD88_enti_e38
TLR9:CpGDNA:MyD88
TLR9:CpGDNA:MyD88:IRAk-4_enti_e39
TLR9:CpGDNA:MyD88:IRAk-4
TLR7:ssRNA:MyD88_enti_e40
TLR7:ssRNA:MyD88
TLR7:ssRNA:MyD88:IRAK4_enti_e41
TLR7:ssRNA:MyD88:IRAK4
TLR7:ssRNA:MyD88:IRAK4:IRAK1_enti_e42
TLR7:ssRNA:MyD88:IRAK4:IRAK1
TLR9:CpGDNA:MyD88:IRAk-4:IRAK1_enti_e43
TLR9:CpGDNA:MyD88:IRAk-4:IRAK1
TLR7:ssRNA:MyD88:IRAK4:IRAK1:TRAF6_enti_e44
TLR7:ssRNA:MyD88:IRAK4:IRAK1:TRAF6
TLR9:CpGDNA:MyD88:IRAk-4:IRAK1:TRAF6_enti_e45
TLR9:CpGDNA:MyD88:IRAk-4:IRAK1:TRAF6
TAK1_enti_MO000016574
TAK1
TAK1{active}_enti_e36
TAK1{active}
IKK-beta_enti_MO000000211
IKK-beta
IKK-alpha_enti_MO000000210
IKK-alpha
IKK_enti_MO000000248
IKK
IKK-gamma_enti_MO000016599
IKK-gamma
IKK{active}_enti_e46
IKK{active}
IKappaB:NF-KappaB_enti_e47
IKappaB:NF-KappaB
IKappaB{p}:NF-KappaB_enti_e48
IKappaB{p}:NF-KappaB
IKappaB{p}{ub}:NF-KappaB_enti_e49
IKappaB{p}{ub}:NF-KappaB
degradants_enti_e63
degradants
NF-kappaB_enti_e64
NF-kappaB
Inflammatory cytokines_enti_e65
Inflammatory cytokines
MKK3_enti_MO000016966
MKK3
MKK6_enti_MO000019005
MKK6
MKK6{active}_enti_e66
MKK6{active}
MKK3{active}_enti_e67
MKK3{active}
p38_enti_MO000000022
p38
p38{active}_enti_e68
p38{active}
JNK_enti_MO000000023
JNK
JNK{active}_enti_e69
JNK{active}
Cot_enti_MO000000041
Cot
MEK1_enti_MO000000078
MEK1
MEK2_enti_MO000009393
MEK2
MEK2{p}_enti_MO000038410
MEK2{p}
MEK1{p}_enti_MO000038670
MEK1{p}
IRF-7_enti_MO000007702
IRF-7
IRF-7{p}_enti_e70
IRF-7{p}
IRF-7{p}_enti_e71
IRF-7{p}
AKT_enti_MO000000048
AKT
GSK3{p}_enti_e10
GSK3{p}
CAMP dependent kinase_enti_e72
CAMP dependent kinase
PKC_enti_MO000000104
PKC
IL-1beta_enti_MO000016597
IL-1beta
IL-1beta_enti_G010389
IL-1beta
NF-kappaB_enti_e73
NF-kappaB
TNF-alpha_enti_MO000000289
TNF-alpha
TNF-alpha_enti_e74
TNF-alpha
IL-12_enti_MO000017265
IL-12
IFNgamma_enti_MO000016665
IFNgamma
IFN-gamma_enti_G010453
IFN-gamma
IL-12_enti_e75
IL-12
AP-1_enti_MO000000276
AP-1
AP-1{active}_enti_e76
AP-1{active}
Egr-1_enti_MO000017190
Egr-1
Egr-1{active}_enti_e77
Egr-1{active}
Inhibitors of PI3K_enti_e78
Inhibitors of PI3K
p85_enti_e79
p85
PI3K{active}_enti_e80
PI3K{active}
LPS:TLR4:MyD88:p85_enti_e81
LPS:TLR4:MyD88:p85
TLR5:Flagellin:MyD88_enti_e82
TLR5:Flagellin:MyD88
TLR5:Flagellin:MyD88:p85_enti_e83
TLR5:Flagellin:MyD88:p85
IL-18_enti_MO000016625
IL-18
p85 receptor_enti_e84
p85 receptor
p85:p85 receptor_enti_e85
p85:p85 receptor
TLR2:PGN:p85_enti_e86
TLR2:PGN:p85
TLR3:dsRNA:TRIF:p85_enti_e87
TLR3:dsRNA:TRIF:p85
p110alpha_enti_MO000017257
p110alpha
TRIF:p110alpha_enti_e88
TRIF:p110alpha
RIP1_enti_MO000000065
RIP1
RIP1:p85_enti_e89
RIP1:p85
AKT{active}_enti_e90
AKT{active}
CpGDNA_enti_e91
CpGDNA
TNF-alpha receptor_enti_e92
TNF-alpha receptor
TNF-alpha:TNF-alpha receptor_enti_e93
TNF-alpha:TNF-alpha receptor
Src-family tyrosine kinase_enti_e94
Src-family tyrosine kinase
Src family tyrosine kinase:TRAF6_enti_e95
Src family tyrosine kinase:TRAF6
LPS:TLR4:TRAM:TRIF_enti_e96
LPS:TLR4:TRAM:TRIF
TBK1_enti_MO000019331
TBK1
IKK-i_enti_MO000016608
IKK-i
LPS:TLR4:TRAM:TRIF:TBK1:IKK-i:Rip1_enti_e97
LPS:TLR4:TRAM:TRIF:TBK1:IKK-i:Rip1
IRF-3_enti_MO000007694
IRF-3
IRF-3{p}_enti_e98
IRF-3{p}
IRF-3{p}_enti_e99
IRF-3{p}
IFN-beta_enti_G010228
IFN-beta
IFN inducible genes_enti_e100
IFN inducible genes
dsRNA:TLR3:TRIF:TBK1:IKK-i:RIP1_enti_e101
dsRNA:TLR3:TRIF:TBK1:IKK-i:RIP1
RON_enti_MO000017853
RON