1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17890055.csml convertedTime:2009.07.01.11:08

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title IRAK1: a critical signaling mediator of innate immunity.
Authors Gottipati S, Rao NL, Fung-Leung WP.
Affiliation Immunology, Johnson & Johnson Pharmaceutical Research and Development, L.L.C.,San Diego, CA 92121, USA.
Abstract The innate immune system is equipped with sensitive and efficient machineries toprovide an immediate, first line defense against infections. Toll-like receptors(TLRs) detect pathogens and the IL-1 receptor (IL-1R) family enables cells toquickly respond to inflammatory cytokines by mounting an efficient protectiveresponse. Interleukin-1 receptor activated kinases (IRAKs) are key mediators inthe signaling pathways of TLRs/IL-1Rs. By means of their kinase and adaptorfunctions, IRAKs initiate a cascade of signaling events eventually leading toinduction of inflammatory target gene expression. Due to this pivotal role, IRAKfunction is also highly regulated via multiple mechanisms. In this review, wefocus on IRAK1, the earliest known and yet the most interesting member of thisfamily. An overview on its structure, function and biology is given, withemphasis on the different novel mechanisms that regulate IRAK1 function. We alsohighlight several unresolved questions in this field and evaluate the potentialof IRAK1 as a target for therapeutic intervention.
PMID 17890055
Model Abstract

Entity

G010262:IL-6 G010292:IL-5 G010329:TNF-alpha G010530:IL-13 G011345:IL10 MO000000058:NF-kappaB MO000000077:MAPKs{active} MO000000212:TRAF6 MO000000214:IL-1 MO000000289:TNF-alpha MO000007321:IL-13 MO000007384:IL-6 MO000013122:STAT3 MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016665:IFNgamma MO000016882:LPS MO000017013:IL-5 MO000017265:IL-12 MO000019394:TLR4 MO000019406:Tollip MO000022125:TAB2 MO000022136:Ubc13 MO000039077:IRAK-4 MO000041419:Pellino1 MO000042012:TLR9 MO000042126:TLR7 MO000044192:Bcl-10 e1: e10:TLR9:Ligand e11:IL-33R e12:IRAK1 e13:IFN-alpha e14:IFN_alpha e15:Activating Ligand e16:TLR7:Ligand e17:IL-12 e18:IRAK1:Tollip e19:TLR e2: e20:TLR:Ligand e21:IL-1:IL-1R:MyD88 e22:TLR:Ligand:MyD88 e23:IL-1:IL-1R:MyD88:IRAK1:Tollip e24:TLR:Ligand:MyD88:IRAK1:Tollip e25:IL-1:IL-1R:MyD88:IRAK1:Tollip:IRAK-4 e26:TLR:Ligand:MyD88:IRAK1:Tollip:IRAK-4 e27:IL-1:IL-1R:MyD88:IRAK1:Tollip:IRAK-4:TRAF6 e28:TLR:Ligand:MyD88:IRAK1:Tollip:IRAK-4:TRAF6 e29:IL-1:IL-1R:MyD88:IRAK1{p}:Tollip:IRAK-4:TRAF6 e3: e30:TLR:Ligand:MyD88:IRAK1{p}:Tollip:IRAK-4:TRAF6 e31:IL-1:IL-1R:MyD88:IRAK1{p}{p}:Tollip:IRAK-4:TRAF6 e32:TLR:Ligand:MyD88:IRAK1{p}{p}:Tollip:IRAK-4:TRAF6 e33:IRAK1{p}:TRAF6 e34:IL-1:IL-1R:MyD88::Tollip:IRAK-4 e35:TLR:Ligand:MyD88:IRAK4:Tollip e36:IRAK1:TRAF6:IRAK-4:Pellino1 e37:IRAK1:TRAF6:IRAK-4:Pellino1:TAK1 e38:Uev1A e39:IRAK1:TRAF6:Pellino1:IRAK-4:TAK1:TAB1:TAB2 e4: e40:MAPKs e41:NF-kappaB{active} e42:Proinflammatory cytokines e43:IRAK1{sumo} e44:IRAK1 e45:STAT3{p} e46:IL10gene e47:IRAK1:IL-10promoter e48:IRF7 e49:TLR9:Ligand:MyD88:IRAK1:TRAF6:IRF7{p} e5:IL-1R e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IL-1:IL-1R e60: e61: e62: e63:TLR7:Ligand:MyD88 e64:IRF7 e66:degradants e67:LPS:TLR4 e68:PKC specific inhibitors e69:IRAK1c e7:IL-33 e70:IRAK1:IRAK1c e71:IRAK1:IRAK1c:Tollip e72:IRAK2 e73:IRAK2:IRAK1c e74:IRAK1c:IRAK2:Tollip e75:TLR:Ligand:MyD88:IRAK1c:IRAK2:Tollip e76:TLR:Ligand:MyD88:IRAK1c:IRAK2:Tollip:TRAF6 e77:TLR:Ligand:MyD88:IRAK1c:IRAK1:Tollip e78:TLR:Ligand:MyD88:IRAK1c:IRAK1:Tollip:TRAF6 e79:GMCSF e8:IL-33:IL-33R e80:GMCSF-R e81:GMCSF:GMCSF-R e82:IFN-gammaR e83:GMCSF:GMCSF-R e84:TLR:Ligand:MyD88:IRAK1:Tollip:IRAK-4:TRAF6:BCL-10 e85:TLR9:Ligand:MyD88 e86:TLR9:Ligand:MyD88:IRAK1 e87:TLR9:Ligand:MyD88:IRAK1:TRAF6 e88:TLR9:Ligand:MyD88:IRAK1:TRAF6:IRF7 e89:TLR7:Ligand:MyD88:IRAK1 e9: e90:TLR7:Ligand:MyD88:IRAK1:TRAF6 e91:TLR7:Ligand:MyD88:IRAK1:TRAF6:IRF7 e92:TLR7:Ligand:MyD88:IRAK1:TRAF6:IRF7{P}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p7 p8 p9
Model Detail
530.0, 713.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p3

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
508.0, 788.0
23.0, 23.0

IL-5

--

G010292

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m93275

10

false

infinite

0

unit false false false
TRANSFACG010292

--

Go back
606.0, 693.0
28.0, 28.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p2 p9

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
507.0, 846.0
25.0, 25.0

IL-13

--

G010530

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p6

true true true true

csml-variable:Double

m93493

10

false

infinite

0

unit false false false
TRANSFACG010530

--

Go back
638.0, 937.0
35.0, 35.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
1081.0, 944.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
892.0, 848.0
24.0, 24.0

MAPKs{active}

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p34

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
537.0, 328.0
22.0, 22.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37 p45

p21 p22 p52 p54 p60 p63

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
343.0, 38.0
25.5, 25.5

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
223.0, 554.0
25.0, 25.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2 p9

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
223.0, 838.0
25.0, 25.0

IL-13

--

MO000007321

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m836

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000007321

--

Go back
225.0, 624.0
22.0, 22.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
773.0, 721.0
21.0, 21.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
892.0, 287.0
24.0, 24.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p16 p58 p44

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
990.0, 409.0
28.0, 28.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
954.0, 566.0
20.0, 20.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
229.0, 1092.0
22.0, 22.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1260.0, 891.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
213.0, 676.0
21.0, 21.0

IL-5

--

MO000017013

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m1913

10

false

infinite

0

unit false false false
InterProIPR000186
TRANSPATHMO000017013

--

Go back
1239.0, 511.0
25.0, 25.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1178.0, 889.0
20.0, 20.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
829.0, 597.0
22.0, 22.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p48 p50

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
1002.0, 570.0
20.0, 20.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
921.0, 601.0
22.0, 22.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
850.0, 318.0
20.0, 20.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p29

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1017.0, 380.0
21.0, 21.0

Pellino1

--

MO000041419

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m19287

10

false

infinite

0

unit false false false
TRANSPATHMO000041419

--

Go back
1180.0, 487.0
23.0, 23.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1177.0, 540.0
21.0, 21.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
494.0, 145.0
22.0, 22.0

Bcl-10

--

MO000044192

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m21910

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044192

--

Go back
285.75, 61.99690800911759
932.3356450860323, 1353.751356664917

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
1181.5, 414.0
21.56610392457794, 41.74084630563473

TLR9:Ligand

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p10

p9 p11 p12 p58

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
319.5, 719.0
25.725834797891032, 39.57820738137082

IL-33R

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
712.0, 426.5
24.639999999999997, 18.47999999999999

IRAK1

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p9 p11 p12 p13 p47 p59 p62

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1260.5, 650.0
15.823103240088548, 25.659086335278722

IFN-alpha

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7 p12

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
770.0, 780.0
44.273356401384085, 23.612456747404842

IFN_alpha

--

e14

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p41

p7 p12

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1286.0, 493.5
27.978910369068544, 18.18629173989455

Activating Ligand

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8 p10 p14

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1180.5, 586.0
22.06906380179785, 42.71431703573778

TLR7:Ligand

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p7 p44

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
640.0, 675.0
47.64705882352941, 25.411764705882355

IL-12

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p11

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
758.5, 260.0
19.53957673721046, 23.926012331278123

IRAK1:Tollip

--

e18

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p13

p17 p18

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1178.5, 347.0
26.045694200351495, 40.07029876977152

TLR

--

e19

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p14

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
285.75, 61.99690800911759
932.3356450860323, 1353.751356664917

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1180.5, 285.0
22.67397500548125, 43.88511291383468

TLR:Ligand

--

e20

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p14

p16

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
725.5, 79.0
28.2352725270692, 39.39805468893377

IL-1:IL-1R:MyD88

--

e21

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p15

p17

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1177.5, 231.0
28.2352725270692, 39.39805468893377

TLR:Ligand:MyD88

--

e22

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p16

p18 p51 p53

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
596.0, 63.0
23.91176470588236, 39.852941176470594

IL-1:IL-1R:MyD88:IRAK1:Tollip

--

e23

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p17

p19

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1176.0, 163.0
23.91176470588236, 39.852941176470594

TLR:Ligand:MyD88:IRAK1:Tollip

--

e24

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p18

p20

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
909.0, 68.0
22.852941176470594, 38.08823529411766

IL-1:IL-1R:MyD88:IRAK1:Tollip:IRAK-4

--

e25

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p19

p21

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1149.0, 72.0
22.852941176470594, 38.08823529411766

TLR:Ligand:MyD88:IRAK1:Tollip:IRAK-4

--

e26

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p20

p22

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
316.0, 211.0
24.264705882352946, 40.441176470588246

IL-1:IL-1R:MyD88:IRAK1:Tollip:IRAK-4:TRAF6

--

e27

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p21

p23

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
317.0, 404.0
22.852941176470594, 38.08823529411766

TLR:Ligand:MyD88:IRAK1:Tollip:IRAK-4:TRAF6

--

e28

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p22

p24 p57

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
320.0, 291.0
24.264705882352946, 40.441176470588246

IL-1:IL-1R:MyD88:IRAK1{p}:Tollip:IRAK-4:TRAF6

--

e29

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p23

p25

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
304.3967129017206, 80.64362091083827
895.0422192825906, 1316.4579308614768

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
317.0, 476.0
22.852941176470594, 38.08823529411766

TLR:Ligand:MyD88:IRAK1{p}:Tollip:IRAK-4:TRAF6

--

e30

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p24

p26

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
316.0, 351.0
24.264705882352946, 40.441176470588246

IL-1:IL-1R:MyD88:IRAK1{p}{p}:Tollip:IRAK-4:TRAF6

--

e31

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p25

p27

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
317.0, 592.0
22.852941176470594, 38.08823529411766

TLR:Ligand:MyD88:IRAK1{p}{p}:Tollip:IRAK-4:TRAF6

--

e32

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p26

p28

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
834.5, 403.0
26.953674387602064, 33.00449925012497

IRAK1{p}:TRAF6

--

e33

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p27 p28

p29 p37 p45

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
317.0, 144.0
22.852941176470594, 38.08823529411766

IL-1:IL-1R:MyD88::Tollip:IRAK-4

--

e34

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p27

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
320.0, 899.0
23.91176470588236, 39.852941176470594

TLR:Ligand:MyD88:IRAK4:Tollip

--

e35

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p28

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
917.0, 468.0
22.5, 37.50000000000001

IRAK1:TRAF6:IRAK-4:Pellino1

--

e36

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p29

p30

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1077.0, 553.0
22.5, 37.50000000000001

IRAK1:TRAF6:IRAK-4:Pellino1:TAK1

--

e37

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p30

p31

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
904.0, 627.0
15.115996258185222, 34.88306828811974

Uev1A

--

e38

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p31

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1000.0, 760.0
24.26470588235294, 40.441176470588246

IRAK1:TRAF6:Pellino1:IRAK-4:TAK1:TAB1:TAB2

--

e39

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p31

p32 p33

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
338.8931317699039, 113.2753684888491
826.0493815462248, 1251.1944357054533

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
940.0, 780.0
24.0, 24.0

MAPKs

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
905.0, 948.0
22.0, 22.0

NF-kappaB{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

p35

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
728.0, 891.0
48.477508650519034, 25.85467128027682

Proinflammatory cytokines

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p34 p35

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
692.0, 522.5
24.639999999999997, 18.47999999999999

IRAK1{sumo}

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

p37

p36

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
668.0, 626.5
24.639999999999997, 18.47999999999999

IRAK1

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p36

p38 p40

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
781.0, 673.0
21.0, 21.0

STAT3{p}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
563.0, 766.5
49.62058901565401, 10.751127620058371

IL10gene

--

e46

cso30:c:Dna

cso30:i:CC_Cytoplasm

--

--

p40

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
637.0, 832.5
45.72897917202366, 12.956544098740038

IRAK1:IL-10promoter

--

e47

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p40

p39

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
484.0, 460.5
32.44515999195009, 20.00784866170256

IRF7

--

e48

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p61 p65

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
308.0, 663.0
23.64705882352942, 39.41176470588236

TLR9:Ligand:MyD88:IRAK1:TRAF6:IRF7{p}

--

e49

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p42

p43

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
375.5, 76.0
24.446397188049207, 37.609841827768015

IL-1R

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
423.0, 592.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
473.29367619468036, 602.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
429.06992643728904, 597.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
429.93705878547314, 598.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
423.0, 592.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
423.0, 592.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
429.93705878547314, 598.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
762.9158804881849, 765.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
686.6082338479803, 886.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
423.0, 592.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
448.5, 69.0
22.422495066871296, 43.398377548783166

IL-1:IL-1R

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3 p2 p15

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
532.7511016961721, 779.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
532.2586758712023, 758.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
553.4329863449013, 817.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1175.5, 730.0
24.715727656450724, 34.48706184621031

TLR7:Ligand:MyD88

--

e63

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p44

p62

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
674.0, 855.5
27.313342724894344, 16.84322801368485

IRF7

--

e64

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p43 p66

p41

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1091.0, 347.0
25.692130959218833, 24.835726593911538

degradants

--

e66

cso30:c:EntityBiological

cso30:i:CC_Cytoplasm

--

p45

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1180.5, 962.0
22.130234597675948, 42.83271212453409

LPS:TLR4

--

e67

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p46

p45

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1254.0, 315.5
27.216743811632117, 16.783658683839807

PKC specific inhibitors

--

e68

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p45

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
921.0, 993.5
29.233246125981083, 18.027168444355

IRAK1c

--

e69

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p47 p49

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
226.0, 710.5
27.275922671353257, 17.729349736379618

IL-33

--

e7

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
1012.5, 1134.0
22.37293784369272, 27.395434094317615

IRAK1:IRAK1c

--

e70

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p47

p48

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
828.5, 1056.0
23.27950082583961, 32.483024408148296

IRAK1:IRAK1c:Tollip

--

e71

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p48

p53

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
864.0, 1039.5
23.519999999999996, 17.64

IRAK2

--

e72

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p49

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
888.5, 1090.0
22.37293784369272, 27.395434094317615

IRAK2:IRAK1c

--

e73

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p49

p50

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
855.5, 1219.0
24.71572765645072, 34.48706184621031

IRAK1c:IRAK2:Tollip

--

e74

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p50

p51

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1177.0, 1200.0
22.411764705882355, 37.352941176470594

TLR:Ligand:MyD88:IRAK1c:IRAK2:Tollip

--

e75

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p51

p52

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1177.0, 1120.0
22.411764705882355, 37.352941176470594

TLR:Ligand:MyD88:IRAK1c:IRAK2:Tollip:TRAF6

--

e76

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p52

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1177.0, 1040.0
22.411764705882355, 37.352941176470594

TLR:Ligand:MyD88:IRAK1c:IRAK1:Tollip

--

e77

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p53

p54

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1177.0, 1296.0
22.411764705882355, 37.352941176470594

TLR:Ligand:MyD88:IRAK1c:IRAK1:Tollip:TRAF6

--

e78

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p54

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
232.0, 952.5
32.61420809015898, 20.112094988931375

GMCSF

--

e79

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p55

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
317.5, 782.0
21.43016882262662, 41.477746108309596

IL-33:IL-33R

--

e8

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5 p6

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
313.5, 980.0
29.79261862917399, 45.83479789103691

GMCSF-R

--

e80

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p55

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
316.5, 1054.0
22.211795658846743, 42.99057224292919

GMCSF:GMCSF-R

--

e81

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p45 p55

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
315.5, 1135.0
25.49736379613357, 39.22671353251317

IFN-gammaR

--

e82

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p56

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
320.5, 1202.0
22.211795658846743, 42.99057224292919

GMCSF:GMCSF-R

--

e83

cso30:c:Complex

cso30:i:CC_Extracellular

--

p56

p45

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
317.0, 92.0
22.852941176470594, 38.08823529411766

TLR:Ligand:MyD88:IRAK1:Tollip:IRAK-4:TRAF6:BCL-10

--

e84

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p57

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
1175.5, 662.0
24.715727656450724, 34.48706184621031

TLR9:Ligand:MyD88

--

e85

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p58

p59

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1172.0, 119.0
23.64705882352942, 39.41176470588236

TLR9:Ligand:MyD88:IRAK1

--

e86

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p59

p60

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
972.0, 55.0
23.64705882352942, 39.41176470588236

TLR9:Ligand:MyD88:IRAK1:TRAF6

--

e87

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p43 p60

p61

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
312.0, 535.0
23.64705882352942, 39.41176470588236

TLR9:Ligand:MyD88:IRAK1:TRAF6:IRF7

--

e88

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p61

p42

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1168.0, 811.0
23.64705882352942, 39.41176470588236

TLR7:Ligand:MyD88:IRAK1

--

e89

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p62

p63

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
332.0, 112.0
848.3059252188473, 1221.1615114449457

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1108.0, 1360.0
23.64705882352942, 39.41176470588236

TLR7:Ligand:MyD88:IRAK1:TRAF6

--

e90

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p63 p66

p65

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
864.0, 1359.0
23.64705882352942, 39.41176470588236

TLR7:Ligand:MyD88:IRAK1:TRAF6:IRF7

--

e91

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p65

p64

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
620.0, 1359.0
23.64705882352942, 39.41176470588236

TLR7:Ligand:MyD88:IRAK1:TRAF6:IRF7{P}

--

e92

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p64

p66

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
417.0, 40.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m185*m5*0.1

nodelay

--

true

0

false

PMID: 17890055 IL-1 induces a wide variety of inflammatory mediators including IL-6 and tumor necrosis factor (TNF) alpha.

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1258.0, 425.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e15 MO000042012

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m15*m19828*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IFN-alpha production induced by intravenous injection of TLR7 agonists is completely blocked in IRAK1-deficient mice but IL-12 production remains normal PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

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926.0, 514.0
20.0, 20.0

p11

p11

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e12 e17 e10

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m12*m17*m10*0.1

nodelay

--

true

0

false

PMID: 17890055,12626533 However, another study using splenocytes from IRAK1-deficient animals reported a significant reduction in TNF-alpha and IL-12 upon TLR9 activation

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1065.0, 696.0
21.0, 21.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e14 e12 e10

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m14*m12*m10*0.1

nodelay

--

true

0

false

PMID: 17890055 Together, these results suggest that IRAK1 plays a specific and essential role in IFN-alpha induction downstream of TLR7 and TLR9

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745.0, 348.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e12 MO000019406

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m12*m3973*0.1

nodelay

--

true

0

false

PMID: 17890055,10854325,16428431 Prior to receptor activation, IRAK1 is associated with Tollip in the cytosol

Go back
1289.0, 356.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e19 e15

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m19*m15*0.1

nodelay

--

true

0

false

PMID: 17890055 Upon ligand binding to TLR/IL-1R, myeloid differentiation factor 88 (MyD88) is rapidly recruited to the receptor via interaction of Toll/IL-1R (TIR) domains which are present in both MyD88 and TLR/IL-1R.

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730.0, 193.0
19.0, 19.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e6 MO000016573

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 17890055 Upon ligand binding to TLR/IL-1R, myeloid differentiation factor 88 (MyD88) is rapidly recruited to the receptor via interaction of Toll/IL-1R (TIR) domains which are present in both MyD88 and TLR/IL-1R.

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1002.0, 318.0
19.0, 19.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016573 e20

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m1572*m20*0.1

nodelay

--

true

0

false

PMID: 17890055 Upon ligand binding to TLR/IL-1R, myeloid differentiation factor 88 (MyD88) is rapidly recruited to the receptor via interaction of Toll/IL-1R (TIR) domains which are present in both MyD88 and TLR/IL-1R.

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637.0, 248.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e18 e21

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m18*m21*0.1

nodelay

--

true

0

false

PMID: 17890055,9430229,17276401 IRAK1 is also recruited to the receptor complex through a death domain interaction with MyD88

Go back
993.0, 240.0
21.0, 21.0

p17

p18

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e18 e22

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m18*m22*0.1

nodelay

--

true

0

false

PMID: 17890055,9430229,17276401 IRAK1 is also recruited to the receptor complex through a death domain interaction with MyD88

Go back
845.0, 216.0
21.0, 21.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e23 MO000039077

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m23*m17258*0.1

nodelay

--

true

0

false

PMID: 17890055,11960013 ,12538665 Binding to MyD88 brings IRAK1 and IRAK4 together at the receptor complex and facilitates the phosphorylation of IRAK1 by IRAK4 at Thr-209 and Thr-387

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456.0, 559.0
23.0, 23.0

p3

p2

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e6

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c8 : 1

m93309*m6*0.1

nodelay

--

true

0

false

PMID: 17890055 IL-1 induces a wide variety of inflammatory mediators including IL-6 and tumor necrosis factor (TNF) alpha.

Go back
933.0, 224.0
21.0, 21.0

p19

p20

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000039077 e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m17258*m24*0.1

nodelay

--

true

0

false

PMID: 17890055,11960013 ,12538665 Binding to MyD88 brings IRAK1 and IRAK4 together at the receptor complex and facilitates the phosphorylation of IRAK1 by IRAK4 at Thr-209 and Thr-387

Go back
538.0, 221.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000212 e25

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c65 : 1
stoichiometry:c67 : 1

m183*m25*0.1

nodelay

--

true

0

false

PMID: 17890055,11287640 IRAK1 also binds tumor necrosis factor receptor-associated factor 6 (TRAF6) through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain PMID: 17890055 IRAK1 also interacts with TRAF6

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562.0, 413.0
19.0, 19.0

p21

p22

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000212 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m183*m26*0.1

nodelay

--

true

0

false

PMID: 17890055,11287640 IRAK1 also binds tumor necrosis factor receptor-associated factor 6 (TRAF6) through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain PMID: 17890055 IRAK1 also interacts with TRAF6

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393.0, 272.0
21.0, 21.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e27

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17890055,11960013 ,12538665 Binding to MyD88 brings IRAK1 and IRAK4 together at the receptor complex and facilitates the phosphorylation of IRAK1 by IRAK4 at Thr-209 and Thr-387

Go back
381.0, 460.0
21.0, 21.0

p23

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 17890055,11960013 ,12538665 Binding to MyD88 brings IRAK1 and IRAK4 together at the receptor complex and facilitates the phosphorylation of IRAK1 by IRAK4 at Thr-209 and Thr-387

Go back
444.0, 339.0
23.0, 23.0

p25

p25

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytoplasm

--

e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17890055,8599092,17141195 This results in the activation of IRAK1 kinase activity and thus the formation of hyper-phosphorylated IRAK1 via auto-phosphorylation

Go back
412.0, 603.0
23.0, 23.0

p25

p26

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytoplasm

--

e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17890055,8599092,17141195 This results in the activation of IRAK1 kinase activity and thus the formation of hyper-phosphorylated IRAK1 via auto-phosphorylation

Go back
518.0, 377.0
22.0, 22.0

p27

p27

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e31

e33 e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17890055,9430229 Since MyD88 and Tollip only bind to non-phosphorylated IRAK1, hyper-phosphorylated IRAK1 is then released from MyD88 and the receptor complex, a key step in this signaling cascade PMID: 17890055 Hyper-phosphorylated IRAK1 then disengages from MyD88 and Tollip, and forms a cytosolic IRAK1-TRAF6 complex

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518.0, 509.0
22.0, 22.0

p27

p28

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e32

e33 e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 17890055,9430229 Since MyD88 and Tollip only bind to non-phosphorylated IRAK1, hyper-phosphorylated IRAK1 is then released from MyD88 and the receptor complex, a key step in this signaling cascade PMID: 17890055 Hyper-phosphorylated IRAK1 then disengages from MyD88 and Tollip, and forms a cytosolic IRAK1-TRAF6 complex

Go back
909.0, 380.0
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e33 MO000041419 MO000039077

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m33*m19287*m17258*0.1

nodelay

--

true

0

false

PMID: 17890055,12496252 An intermediate cytosolic signaling complex composed of Pellino1, IRAK1, IRAK4 and TRAF6 may be formed prior to the interaction of TRAF6 with the downstream signaling molecule TGF-beta activated kinase-1 (TAK1)

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360.0, 631.0
23.0, 23.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e6

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m93248*m6*0.1

nodelay

--

true

0

false

PMID: 17890055 IL-1 induces a wide variety of inflammatory mediators including IL-6 and tumor necrosis factor (TNF) alpha.

Go back
1002.0, 482.0
19.0, 19.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e36 MO000016574

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m36*m1573*0.1

nodelay

--

true

0

false

PMID: 17890055,12496252 An intermediate cytosolic signaling complex composed of Pellino1, IRAK1, IRAK4 and TRAF6 may be formed prior to the interaction of TRAF6 with the downstream signaling molecule TGF-beta activated kinase-1 (TAK1)

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993.0, 616.0
21.0, 21.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e37 MO000022125 MO000016588 MO000022136 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m37*m6433*m1583*m6443*m38*0.1

nodelay

--

true

0

false

PMID: 17890055,10882101,12242293,11057907 Cytosolic TRAF6 interacting with TAK1 eventually forms a macromolecular complex with ubiquitin conjugating enzymes Ubc13 and Uev1A, and TAK1 binding proteins TAB1 and TAB2

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953.0, 853.0
21.0, 21.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e39 e40

MO000000077

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m39*m40*0.1

nodelay

--

true

0

false

PMID: 17890055,11518704,10465784 This leads to TAK1 activation, which in turn activates NF-¦ÊB and MAPK pathways

Go back
1005.0, 945.0
21.0, 21.0

p32

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000058 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m41*m39*0.1

nodelay

--

true

0

false

PMID: 17890055,11518704,10465784 This leads to TAK1 activation, which in turn activates NF-¦ÊB and MAPK pathways

Go back
781.0, 832.0
21.0, 21.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000077

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17890055,11518704,10465784 This leads to TAK1 activation, which in turn activates NF-¦ÊB and MAPK pathways

Go back
809.0, 889.0
21.0, 21.0

p34

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17890055,11518704,10465784 This leads to TAK1 activation, which in turn activates NF-¦ÊB and MAPK pathways

Go back
677.0, 573.0
21.0, 21.0

p36

p36

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 17890055,10899313,15896328 IRAK1 has been reported to translocate to the nucleus upon IL-1 stimulation PMID: 17890055,16690127 A recent study also indicated that IRAK1 undergoes sumoylation followed by nuclear translocation in monocytes stimulated with TLR ligands

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736.0, 480.0
23.0, 23.0

p37

p37

cso30:i:ME_Sumoylation

cso30:i:CC_Cytoplasm

--

e33

e43 MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 17890055,16690127 A recent study also indicated that IRAK1 undergoes sumoylation followed by nuclear translocation in monocytes stimulated with TLR ligands

Go back
734.0, 677.0
19.0, 19.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e44 MO000013122

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m45*m1360*0.1

nodelay

--

true

0

false

PMID: 17890055,15465816 Within the nucleus, IRAK1 has been reported to phosphorylate transcription factor Stat3 and bind directly to the IL-10 gene promoter for IL-10 expression

Go back
634.0, 889.0
20.0, 20.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 17890055,15465816 Within the nucleus, IRAK1 has been reported to phosphorylate transcription factor Stat3 and bind directly to the IL-10 gene promoter for IL-10 expression

Go back
230.0, 785.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e7 e11

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m7*m11*0.1

nodelay

--

true

0

false

PMID: 17890055,16286016 IL-33-treatment of Th2 T cells induces IL-5 and IL-13 production

Go back
649.0, 769.0
21.0, 21.0

p40

p40

cso30:i:ME_DNABinding

cso30:i:CC_NuclearEnvelopeLumen

--

e44 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m45*m47*0.1

nodelay

--

true

0

false

PMID: 17890055,15465816 Within the nucleus, IRAK1 has been reported to phosphorylate transcription factor Stat3 and bind directly to the IL-10 gene promoter for IL-10 expression

Go back
721.0, 813.0
21.0, 21.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e64

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IRAK1 directly binds IRF7 and its kinase activity is critical for the phosphorylation and activation of IRF7, a requirement for IRF7 nuclear translocation and INF-alpha production PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
290.0, 598.0
19.0, 19.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e88

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IRAK1 directly binds IRF7 and its kinase activity is critical for the phosphorylation and activation of IRF7, a requirement for IRF7 nuclear translocation and INF-alpha production PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
737.0, 540.0
21.0, 21.0

p43

p43

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e49

e64 e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c127 : 1
stoichiometry:c124 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IRAK1 directly binds IRF7 and its kinase activity is critical for the phosphorylation and activation of IRF7, a requirement for IRF7 nuclear translocation and INF-alpha production PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
1066.0, 769.0
19.0, 19.0

p58

p44

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016573 e16

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m1572*m16*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-greek small letter alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7)

Go back
924.0, 336.0
23.0, 23.0

p45

p45

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

e33 e67 e68 e81 e83

e66 MO000000212

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c166 : 1
stoichiometry:c170 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m33*m68*0.1

nodelay

--

true

0

false

PMID: 17890055,9261174 The loss of IRAK1 protein is due to proteasome-mediated degradation as demonstrated by studies using proteasome inhibitors PMID: 17890055,11937546 TLR4 activation can also trigger rapid IRAK1 degradation that can be blocked by protein kinase C (PKC) specific inhibitors PMID: 17890055,12032143 Interestingly, degradation of IRAK1 in LPS-tolerant THP-1 cells can be prevented by pretreatment with GM-CSF and IFN-¦Ã

Go back
1262.0, 973.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019394 MO000016882

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 17890055,11937546 TLR4 activation can also trigger rapid IRAK1 degradation that can be blocked by protein kinase C (PKC) specific inhibitors

Go back
1013.0, 992.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e12 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m12*m71*0.1

nodelay

--

true

0

false

PMID: 17890055 In resting cells, IRAK1c dimerizes with IRAK1 or IRAK2 and associates with Tollip.

Go back
789.0, 1125.0
21.0, 21.0

p47

p48

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e70 MO000019406

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m72*m3973*0.1

nodelay

--

true

0

false

PMID: 17890055 n resting cells, IRAK1c dimerizes with IRAK1 or IRAK2 and associates with Tollip.

Go back
913.0, 1041.0
21.0, 21.0

p47

p49

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e69 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m71*m74*0.1

nodelay

--

true

0

false

PMID: 17890055 In resting cells, IRAK1c dimerizes with IRAK1 or IRAK2 and associates with Tollip.

Go back
388.0, 723.0
23.0, 23.0

p5

p5

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010292 e8

MO000017013

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m93275*m8*0.1

nodelay

--

true

0

false

PMID: 17890055,16286016 IL-33-treatment of Th2 T cells induces IL-5 and IL-13 production

Go back
833.0, 1176.0
21.0, 21.0

p47

p50

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e73 MO000019406

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m75*m3973*0.1

nodelay

--

true

0

false

PMID: 17890055 In resting cells, IRAK1c dimerizes with IRAK1 or IRAK2 and associates with Tollip.

Go back
885.0, 1285.0
21.0, 21.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e74 e22

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m76*m22*0.1

nodelay

--

true

0

false

PMID: 17890055 Upon TLR activation, IRAK1c is recruited to the receptor complex and interacts with MyD88 and TRAF6 in a manner similar to IRAK1 and IRAK1-kinase dead mutant.

Go back
1053.0, 1128.0
21.0, 21.0

p51

p52

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000000212 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m183*m77*0.1

nodelay

--

true

0

false

PMID: 17890055 Upon TLR activation, IRAK1c is recruited to the receptor complex and interacts with MyD88 and TRAF6 in a manner similar to IRAK1 and IRAK1-kinase dead mutant.

Go back
845.0, 1008.0
21.0, 21.0

p51

p53

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e22 e71

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m22*m73*0.1

nodelay

--

true

0

false

PMID: 17890055 Upon TLR activation, IRAK1c is recruited to the receptor complex and interacts with MyD88 and TRAF6 in a manner similar to IRAK1 and IRAK1-kinase dead mutant.

Go back
965.0, 1308.0
21.0, 21.0

p51

p54

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e77 MO000000212

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m79*m183*0.1

nodelay

--

true

0

false

PMID: 17890055 Upon TLR activation, IRAK1c is recruited to the receptor complex and interacts with MyD88 and TRAF6 in a manner similar to IRAK1 and IRAK1-kinase dead mutant.

Go back
224.0, 1011.0
23.0, 23.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e79 e80 e81

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m81*m82*m83*0.1

nodelay

--

true

0

false

PMID: 17890055,12032143 Interestingly, degradation of IRAK1 in LPS-tolerant THP-1 cells can be prevented by pretreatment with GM-CSF and IFN-¦Ã

Go back
224.0, 1155.0
23.0, 23.0

p55

p56

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016665 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m1639*m84*0.1

nodelay

--

true

0

false

PMID: 17890055,12032143 Interestingly, degradation of IRAK1 in LPS-tolerant THP-1 cells can be prevented by pretreatment with GM-CSF and IFN-¦Ã

Go back
417.0, 196.0
21.0, 21.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e28 MO000044192

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1
stoichiometry:c173 : 1

m28*m21910*0.1

nodelay

--

true

0

false

PMID: 17890055,16831874 IRAK1 also acts as an upstream adaptor by recruiting B-cell CLL/lymphoma 10 (BCL10) to the TLR signaling complex

Go back
1058.0, 393.0
19.0, 19.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016573 e10

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c199 : 1

m1572*m10*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7) PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
1038.0, 265.0
19.0, 19.0

p58

p59

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e12 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m12*m87*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-greek small letter alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7) PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
394.0, 809.0
20.0, 20.0

p5

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010530 e8

MO000007321

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m93493*m8*0.1

nodelay

--

true

0

false

PMID: 17890055,16286016 IL-33-treatment of Th2 T cells induces IL-5 and IL-13 production

Go back
898.0, 181.0
19.0, 19.0

p58

p60

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e86 MO000000212

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c181 : 1

m88*m183*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7) PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
826.0, 145.0
19.0, 19.0

p58

p61

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e87 e48

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m89*m49*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7) PMID: 17890055,15767370 IRAK1 directly binds IRF7 and its kinase activity is critical for the phosphorylation and activation of IRF7, a requirement for IRF7 nuclear translocation and INF-alpha production PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
1074.0, 821.0
19.0, 19.0

p58

p62

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e63 e12

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m64*m12*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-greek small letter alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7) PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
1066.0, 974.0
19.0, 19.0

p58

p63

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e89 MO000000212

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c190 : 1

m91*m183*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-greek small letter alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7) PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
722.0, 1370.0
19.0, 19.0

p42

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IRAK1 directly binds IRF7 and its kinase activity is critical for the phosphorylation and activation of IRF7, a requirement for IRF7 nuclear translocation and INF-alpha production PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
718.0, 1045.0
19.0, 19.0

p58

p65

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e90 e48

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m92*m49*0.1

nodelay

--

true

0

false

PMID: 17890055 Further biochemical studies showed that IFN-greek small letter alpha induction requires the formation of a signaling complex consisting of IRAK1, MyD88, TRAF6 and IFN-regulatory factor 7 (IRF7) PMID: 17890055,15767370 IRAK1 directly binds IRF7 and its kinase activity is critical for the phosphorylation and activation of IRF7, a requirement for IRF7 nuclear translocation and INF-alpha production PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
609.0, 1052.0
21.0, 21.0

p43

p66

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e92

e90 e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IRAK1 directly binds IRF7 and its kinase activity is critical for the phosphorylation and activation of IRF7, a requirement for IRF7 nuclear translocation and INF-alpha production PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
953.0, 652.0
21.0, 21.0

p7

p7

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e14 e12 e16

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c25 : 1
stoichiometry:c21 : 1

m14*m12*m16*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IFN-alpha production induced by intravenous injection of TLR7 agonists is completely blocked in IRAK1-deficient mice but IL-12 production remains normal PMID: 17890055,15767370 IRAK1 deficiency in plasmacytoid dendritic cells abrogates IFN-alpha production without affecting the production of other inflammatory cytokines such as IL-6 and TNF-alpha

Go back
1282.0, 557.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000042126

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m15*m19940*0.1

nodelay

--

true

0

false

PMID: 17890055,15767370 IFN-alpha production induced by intravenous injection of TLR7 agonists is completely blocked in IRAK1-deficient mice but IL-12 production remains normal PMID: 17890055 As previously mentioned, IRAK1 plays a key role in IFN-alpha gene expression upon TLR7 or TLR9 activation.

Go back
549.0, 461.0
21.0, 21.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e12 G010329 e10

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c33 : 1
stoichiometry:c28 : 1

m12*m93309*m10*0.1

nodelay

--

true

0

false

PMID: 17890055,12626533 However, another study using splenocytes from IRAK1-deficient animals reported a significant reduction in TNF-alpha and IL-12 upon TLR9 activation

Go back
369.0, 51.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
240.0, 728.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.9883381862201, 861.43180206412

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.9986780137067, 955.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.9940893970505, 956.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1012.0, 800.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.9178268547516, 846.1436861012419

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
764.3969320118102, 853.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
836.8195028725718, 910.1826284285107

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.9853479730496, 900.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.5214432661302, 430.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.9195205871675, 503.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
255.84287685959129, 747.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.3436556404091, 351.8742212830262

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.3861999450876, 541.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.1984430354239, 594.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.0, 645.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
757.2850231591362, 702.0057081353821

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.0, 685.2855322440993

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.0866100281773, 645.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.0, 775.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 790.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0396512976733, 845.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
249.0, 796.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.0, 909.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.3332376839457, 574.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.0, 617.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 556.3593175009767

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.0, 101.16822912868474

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.0, 839.4057970281387

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
742.0, 806.7777713001234

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.4919994190315, 561.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.0, 311.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.4797074572284, 624.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.0203968205104, 744.8358869225469

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.0, 753.1192815158148

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.0, 363.03358582934374

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.0, 349.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.997569132428, 339.1972003347722

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.0, 909.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1272.0, 915.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.0, 983.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
943.0007872548604, 366.4158799782

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
950.989768722939, 325.0

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
729.0, 445.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 751.5378014698349

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
950.0, 1003.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 1013.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.9903110128192, 1137.3936113799418

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.5991034677297, 619.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.0, 1094.7942826023123

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.8771242648312, 1012.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 1049.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.3688904516371, 1062.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.4892664309411, 1117.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 619.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.71811056990185, 692.1049392463369

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.0, 1197.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.0, 1253.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.1837449971432, 270.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.0, 1224.0275113999683

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 350.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.7060610249825, 1149.3621950356683

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1074.0, 1139.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
864.2075925416137, 270.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 1036.6703849016671

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
866.0, 1020.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.56471101118376, 824.6029113156761

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.0486997393298, 1072.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.0, 350.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 1315.1675025390364

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
239.64808384839873, 973.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.80674512266586, 1006.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.98854381027053, 1032.8936172657222

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 362.06822937528824

c166

c166

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
237.3897804297073, 1114.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.93280328948978, 1157.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 1173.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.0, 805.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
343.0, 362.2925382429349

c170

c170

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
337.0, 224.26821872418796

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.6746825652904, 163.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.76810380296735, 127.5433724859686

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 307.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1084.7479434607749, 406.99232831848497

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.0, 283.5681904262417

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.619631640199, 291.55893709920036

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 156.65685424949237

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.8619284186578, 141.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.85681823387694, 821.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.0, 198.03501317241293

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.0, 99.71451340436792

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0295008528562, 81.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.0, 169.488102949512

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.30302471039164, 163.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1099.224939209875, 757.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.0, 445.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.0, 831.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1087.4984801712583, 849.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0, 350.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.0, 675.8070533076368

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1077.0, 993.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.1552790744792, 1067.110043005228

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 481.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.0, 1064.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.9997356202184, 1379.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.9993426188411, 1379.1025556746006

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.3074649768097, 1080.9940893970504

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.0, 1069.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 879.5767439267356

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.0, 412.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 66.93228623299017

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.0, 445.0

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
974.0, 663.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1294.0573097607282, 512.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1198.0, 552.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1210.4147970583408, 571.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.7677168938225, 610.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.815917607507, 439.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
564.9489361191736, 489.7589720970874

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
255.6785698670132, 475.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1275.343244865857, 451.2679236214286

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 61.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1203.0, 448.19721862065717

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.0, 435.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.0, 441.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.9869494290375, 436.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
686.0, 534.1369251194046

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
946.0, 524.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.5568379249037, 439.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
814.0, 712.2903766496904

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.0, 445.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1084.1291251227588, 456.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.1845016638977, 651.5189395904805

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1086.0, 666.7825984120171

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 376.39213465937513

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.5597212909255, 376.5794344718312

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 291.9220526307043

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1205.0, 367.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1300.0, 385.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1209.9855816161194, 316.8989292741131

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 95.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.8979525058492, 212.05194412931

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 126.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.98874647770506, 636.4241812289047

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 302.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.9441833872286, 308.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.0, 260.1400381183985

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.9529716332247, 260.8661652273809

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.9977796279167, 118.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.7752939548733, 110.8005340441402

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.0, 252.70423219690917

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.0, 251.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 189.77851484658876

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 90.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.2633303684743, 112.0

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
856.3945808984851, 244.99026319432286

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 113.28293181970083

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.0, 250.93421168758945

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.8265229681834, 186.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0, 102.43760156980183

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.4552421448992, 91.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 248.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 231.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
551.0, 350.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.9647310706142, 97.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.97667739725966, 586.3178310700026

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 423.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 240.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.45889047160114, 287.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 432.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.4526209558805, 475.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 315.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.90697358120497, 353.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 510.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.9930645847388, 611.3330443576974

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 372.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.99852112023876, 567.1538177138508

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.0, 389.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.32044308843194, 181.9743522948314

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 528.3135053278742

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.0, 426.40533720988435

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.54649680729426, 531.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.0, 397.944387608059

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 391.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.0, 338.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.0, 401.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.0, 488.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 112.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 437.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 501.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1020.7051162607964, 579.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1007.2164574740316, 590.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 586.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
943.0, 614.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.0, 630.4871333448388

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.0, 637.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.9407857588142, 800.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
954.0, 804.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back