1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17904888.csml convertedTime:2009.07.01.11:08

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signalling pathways mediating type I interferon gene expression.
Authors Edwards MR, Slater L, Johnston SL.
Affiliation Department of Respiratory Medicine, National Heart and Lung Institute, MRCCentre in Allergic Mechanisms of Asthma, St Marys Campus, Norfolk Place, LondonW2 1PG, UK. michael.edwards@imperial.ac.uk
Abstract Type I interferon-alpha/beta play an essential role in immunity to viruses.While interferon-beta has been used as a model of a complex promoter, many ofthe signalling pathways leading to interferon-beta gene expression remaincontroversial. Recent milestones include the discovery of Toll-like receptorsand RNA helicases that signal via a novel kinase complex composed of I kappa Bkinase-iota/epsilon or TANK binding kinase-1. This review provides a timelysummary of this rapidly expanding field, focusing specifically on the variousviral RNA binding molecules and their associated signalling pathways.
PMID 17904888
Model Abstract

Entity

G010228:IFN-beta MO000000030:PI3K MO000000048:AKT MO000000058:NF-kappaB MO000000065:RIP1 MO000000248:IKK MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016608:IKK-i MO000016660:IFNbeta MO000016903:JNK2{active} MO000017462:CBP MO000019331:TBK1 MO000019398:TLR3 MO000022224:dsRNA MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042126:TLR7 MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10:TANK:TBK1 e11: e12:CpG motif e13:TLR9:CpG DNA e14:TLR9:CpGDNA:MyD88 e15:TLR9:CpGDNA:MyD88:IRF-7 e16:IFN-alpha e17:TRAF6:IRAK-1:IRAK-4 e18:Imiquimod e19:TLR7:Imiquimod e2: e20:MyD88:TRAF6:IRAK-1 e21:TLR7:Imiquimod:MyD88:TRAF6:IRAK-1 e22:IRF-7{active} e23:IRF-5{active} e24:DDX58:ssRNA e25:ssRNA e26:IFIH1:dsRNA:MAVS e27:IFIH1:dsRNA e28:DDX58:dsRNA e29:PKR e3: e30:PKR:dsRNA e31:NF-KappaB:IKappaB e32:NF-KappaB:IKappaB{p} e33:dsRNA:TLR3{p} e34:dsRNA:TLR3{p}:PI3K:TBK1 e35:c-Jun:ATF-2 e36:c-Jun:ATF-2{active} e37:DDX58:dsRNA:MAVS e38:DDx58:dsRNA:MAVS:TANK:TBK1:IKK-i e39:dsRNA:TLR3:TRIF:RIP1 e4: e40:NF-kappaB{active} e41:dsRNA:TLR3:TRIF:TANK:TBK1:IKK-i e42:IRF-3{p} e43:IRF-3{p}:IRF-3{P} e44:IRF-3{active} e45:TANK:TBK1:IKK-i e46:IFIH1:dsRNA:MAVS:TANK:TBK1:IKK-i e47:IFIH1:dsRNA:MAVS:IKK e48:DDx58:dsRNA:MAVS:IKK e49:NS3/4A e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:AKT{active} e64:ISG56 e65:IRF-3{p}:IRF-3{p}:CBP e66:IRF-3{p}:IRF-3{p}:CBP e67:Wortmannin e68:LY294002 e69:ISG56 e7: e70:IRF{p}(2):CBP:ISG56 e71:JNK2 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p5 p6 p7 p8 p9
Model Detail
474.0, 1134.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
799.0, 739.0
26.0, 26.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
964.0, 716.0
16.0, 16.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
738.0, 718.0
20.0, 20.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p36 p38

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
471.0, 595.0
17.0, 17.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
225.0, 681.0
22.0, 22.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p37

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
522.0, 738.0
20.0, 20.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p32 p34 p39

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
964.0, 560.0
24.0, 24.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
501.0, 445.0
22.0, 22.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p8

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
568.0, 188.0
24.0, 24.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
526.0, 646.0
20.0, 20.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1111.0, 1083.0
18.0, 18.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
875.0, 827.0
18.0, 18.0

JNK2{active}

--

MO000016903

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1818

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016903

--

Go back
853.0, 1041.0
22.0, 22.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
781.0, 705.0
22.0, 22.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
646.0, 466.0
20.0, 20.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
227.0, 47.0
25.0, 25.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p11 p13 p23

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
566.0, 606.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
642.0, 534.0
20.0, 20.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
647.0, 491.0
18.0, 18.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
762.0, 282.0
20.0, 20.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
819.0, 327.0
18.0, 18.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
273.0, 201.0
22.0, 22.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
405.0, 321.0
22.0, 22.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p19 p20

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
290.0, 238.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
104.62968862647224, 86.47491328936815
990.7646054546121, 1438.5902071200967

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
523.5, 689.0
17.873854357607062, 21.8863522746209

TANK:TBK1

--

e10

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p27

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
639.0, 275.0
237.5686192706652, 396.6187965789921

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
686.0, 60.0
60.0, 16.0

CpG motif

--

e12

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
694.5, 274.0
18.799824599868447, 36.38675729006797

TLR9:CpG DNA

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
641.5, 353.0
21.630207377500458, 30.181684712791338

TLR9:CpGDNA:MyD88

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
649.0, 414.0
21.617647058823536, 36.02941176470589

TLR9:CpGDNA:MyD88:IRF-7

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
347.0, 1073.0
41.26297577854672, 22.00692041522492

IFN-alpha

--

e16

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
265.5, 861.0
21.093595155074333, 29.43292347219674

TRAF6:IRAK-1:IRAK-4

--

e17

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p4

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1110.0, 324.0
43.85197645079899, 24.849453322119427

Imiquimod

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
846.5, 382.0
18.59592194694146, 35.99210699408024

TLR7:Imiquimod

--

e19

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p5

p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
104.62968862647224, 86.47491328936815
990.7646054546121, 1438.5902071200967

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
969.5, 441.0
20.935768030831348, 29.212699577904203

MyD88:TRAF6:IRAK-1

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
849.0, 462.0
20.999999999999996, 35.0

TLR7:Imiquimod:MyD88:TRAF6:IRAK-1

--

e21

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p6

p7 p8

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
453.0, 481.0
22.0, 22.0

IRF-7{active}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
944.0, 616.0
24.0, 24.0

IRF-5{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
230.5, 305.0
18.404599233461088, 22.536243959340116

DDX58:ssRNA

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
41.0, 184.0
45.62283737024222, 24.332179930795846

ssRNA

--

e25

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
382.5, 359.0
18.663057441732427, 26.041475500091774

IFIH1:dsRNA:MAVS

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
369.5, 275.0
20.682719546742213, 25.3257790368272

IFIH1:dsRNA

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
426.5, 188.0
19.368105315780706, 23.716047325445768

DDX58:dsRNA

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
202.5, 460.0
19.172137977003832, 23.476087318780205

PKR

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
124.44498073556443, 106.29020539846044
951.1340212364279, 1398.9596229019135

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
260.5, 442.0
23.017997000499918, 28.18530244959173

PKR:dsRNA

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
333.5, 663.0
20.5275787368772, 25.135810698216975

NF-KappaB:IKappaB

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
389.5, 715.0
20.5275787368772, 25.135810698216975

NF-KappaB:IKappaB{p}

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
838.0, 554.0
20.0, 20.0

dsRNA:TLR3{p}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
850.5, 511.0
19.152321526885665, 26.724169572398605

dsRNA:TLR3{p}:PI3K:TBK1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
846.5, 888.0
18.82919513414431, 23.05615730711548

c-Jun:ATF-2

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
745.5, 943.0
21.188968505249125, 25.945675720713215

c-Jun:ATF-2{active}

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
549.5, 254.0
20.122958340980002, 28.07854652229767

DDX58:dsRNA:MAVS

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
426.0, 500.0
19.411764705882348, 32.35294117647059

DDx58:dsRNA:MAVS:TANK:TBK1:IKK-i

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
766.0, 623.0
20.82352941176471, 34.70588235294118

dsRNA:TLR3:TRIF:RIP1

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
161.10327113738524, 140.96696658937165
877.8174404327864, 1329.60610052009

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
694.0, 838.0
20.0, 20.0

NF-kappaB{active}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p36 p38

--

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
695.0, 645.0
18.529411764705884, 30.88235294117648

dsRNA:TLR3:TRIF:TANK:TBK1:IKK-i

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
595.0, 771.0
18.0, 18.0

IRF-3{p}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
654.5, 877.0
18.64139310114981, 22.82619563406099

IRF-3{p}:IRF-3{P}

--

e43

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
454.0, 782.0
20.0, 20.0

IRF-3{active}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p34

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
245.5, 517.0
20.998898880528543, 29.300789135621223

TANK:TBK1:IKK-i

--

e45

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p21 p33

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
282.0, 556.0
19.411764705882348, 32.35294117647059

IFIH1:dsRNA:MAVS:TANK:TBK1:IKK-i

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
350.0, 792.0
19.411764705882348, 32.35294117647059

IFIH1:dsRNA:MAVS:IKK

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
454.0, 828.0
19.411764705882348, 32.35294117647059

DDx58:dsRNA:MAVS:IKK

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
841.5, 221.0
13.522237874823908, 21.927953310525258

NS3/4A

--

e49

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p20

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
639.0, 275.0
237.5686192706652, 396.6187965789921

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
289.3512732307094, 964.1081525636613
337.44681810683556, 306.02718886038963

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
325.7980431565873, 971.3605520460984
197.31527166768416, 296.6013000864556

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
293.75002132521183, 968.1927043656993
328.6493219178309, 297.85808525631364

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
294.37841391014103, 968.8210969506284
327.3925367479728, 296.6013000864556

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
289.3512732307094, 964.1081525636613
337.44681810683556, 306.02718886038963

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
289.3512732307094, 964.1081525636613
337.44681810683556, 306.02718886038963

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
294.37841391014103, 968.8210969506284
327.3925367479728, 296.6013000864556

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
535.6811665228497, 1089.786669549448
21.081823092398302, 19.084597746802707

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
480.38261904910405, 1177.7616314394982
59.69729556824843, 54.04176230388816

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
289.3512732307094, 964.1081525636613
337.44681810683556, 306.02718886038963

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
639.0, 275.0
237.5686192706652, 396.6187965789921

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
368.8855895759344, 1100.10410656974
10.686444903427752, 5.145325323872639

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
368.5287389317548, 1084.7595288700165
36.577191028410375, 65.83894385113875

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
383.87331663147893, 1127.5816061715707
5.709610306873806, 5.709610306873822

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
944.0, 768.0
16.0, 16.0

AKT{active}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
416.0, 1186.0
39.29065743944636, 20.955017301038062

ISG56

--

e64

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p41

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
574.5, 902.0
19.47586713158378, 27.175628555698292

IRF-3{p}:IRF-3{p}:CBP

--

e65

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
430.5, 982.0
19.47586713158378, 27.175628555698292

IRF-3{p}:IRF-3{p}:CBP

--

e66

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1111.0, 808.0
42.817493692178296, 24.263246425567704

Wortmannin

--

e67

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p41 p42 p44

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1112.0, 876.0
40.647603027754414, 23.033641715727505

LY294002

--

e68

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p41 p42 p44

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
524.0, 1038.5
48.07641284160255, 10.41655611568055

ISG56

--

e69

cso30:c:Dna

cso30:i:CC_Cytoplasm

--

--

p44

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
117.64689042949377, 92.26391400798133
971.6314065552745, 1376.776605598618

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
429.0, 1053.5
46.13011056826948, 13.070197994343019

IRF{p}(2):CBP:ISG56

--

e70

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
739.0, 811.0
18.0, 18.0

JNK2

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016903

--

Go back
121.11814424363286, 116.5626907069551
932.0975860451996, 1353.4056949376304

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
136.37482108133716, 103.86146740592875
927.8420492773191, 1335.6561183813055

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
719.0, 187.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m12*m19828*0.1

nodelay

--

true

0

false

PMID: 17904888,14971051 TLR9 recognises dsDNA, often in the form of unmethylated CpG deoxyoligonucleotides

Go back
129.0, 201.0
21.0, 21.0

p9

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m25*m41844*0.1

nodelay

--

true

0

false

PMID: 17904888,17038589 RIG-I recognises dsRNA and also is thought to associate with 50-triphosphorylated ssRNA derived from virally infected cells

Go back
321.0, 121.0
21.0, 21.0

p9

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m76904*m119368*0.1

nodelay

--

true

0

false

PMID: 17904888,16127453 MDA5 has a helicase/CARD structure similar to that of RIG-I, and like RIG-I the helicase domain of MDA5 binds to viral dsRNA and its CARD domain can bind to the CARD-containing region of CARDIF/IPS

Go back
313.0, 305.0
21.0, 21.0

p9

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m27*m68199*0.1

nodelay

--

true

0

false

PMID: 17904888,16127453 MDA5 has a helicase/CARD structure similar to that of RIG-I, and like RIG-I the helicase domain of MDA5 binds to viral dsRNA and its CARD domain can bind to the CARD-containing region of CARDIF/IPS

Go back
262.0, 350.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m119368*m29*0.1

nodelay

--

true

0

false

PMID: 17904888 PKR homodimers are constitutively expressed in the cytoplasm, and activated by dsRNA ligation.

Go back
389.0, 601.0
21.0, 21.0

p14

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m31*m30*0.1

nodelay

--

true

0

false

PMID: 17904888,7912826 NF-kB is a target of PKR, activated through phosphorylation of the inhibitor of NF-kB, IkB [35], or activation of the kinase phosphorylating IkB, IKK-a/ b

Go back
797.0, 613.0
21.0, 21.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c44 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 17904888,15502848 An initial study by Sarkar, in HEK293 cells revealed that TLR3 phosphorylation at conserved tyrosine residues within the intracellular domain recruits both TBK1 and PI3K.

Go back
852.5, 693.0
22.5, 22.5

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m33*m34*m3902*0.1

nodelay

--

true

0

false

PMID: 17904888,15502848 An initial study by Sarkar, in HEK293 cells revealed that TLR3 phosphorylation at conserved tyrosine residues within the intracellular domain recruits both TBK1 and PI3K.

Go back
745.0, 873.0
19.0, 19.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m1818*m36*0.1

nodelay

--

true

0

false

PMID: 17904888 JNK2 also activates c-Jun, half of the heterodimeric ATF-2/c-Jun transcription factor required for IFN-b expression

Go back
529.0, 1169.0
21.0, 21.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 17904888 JNK2 also activates c-Jun, half of the heterodimeric ATF-2/c-Jun transcription factor required for IFN-b expression

Go back
570.0, 654.0
19.0, 19.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m68199*m75*0.1

nodelay

--

true

0

false

PMID: 17904888 The upstream activator or dsRNA recognition molecule that activates JNK2 in response to viral infection is currently unknown, however over-expression of the RIG-I adaptor CARDIF/ MAVS/VISA/IPS has been reported to activate JNK

Go back
613.0, 281.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m13*m1572*0.1

nodelay

--

true

0

false

PMID: 17904888,12900525 The downstream signalling proteins required for TLR9 mediated IFN-a gene include the adaptor MyD88, as DCs from MyD88 knockout mice fail to produce IFN-a

Go back
461.0, 221.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c107 : 1
stoichiometry:c56 : 1

m28*m68199*0.1

nodelay

--

true

0

false

PMID: 17904888,16127453 Subsequent biochemical analysis identified RIG-I as an RNA helicase with a self-inhibiting conformation; unwinding of viral dsRNA in the presence of ATP allows the CARD signalling domains access to a CARD containing intermediate, identified by four groups as CARDIF, VISA, MAVS and IPS-1 PMID: 17904888,16585524 NS3or4A was observed to specifically cleave the helicase adaptor IPS-1, causing a loss of RIG-I and IPS-I interaction

Go back
401.0, 397.0
21.0, 21.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c61 : 1

m38*m48*0.1

nodelay

--

true

0

false

PMID: 17904888 This complex then makes contact with a kinase complex, which includes TANK, TANK binding kinase 1 (TBK1) and IKK-i/epsilon.

Go back
547.0, 491.0
18.0, 18.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 17904888,11607032 TLR3 was first identified in 2001 as an extracellular receptor for dsRNA in both human and murine cells

Go back
535.0, 543.0
18.0, 18.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17904888 Further studies identified an important adaptor protein under the control of TLR3, termed TIR domain-containing adapter inducing IFN-b (TRIF)

Go back
586.0, 578.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m19305*m40*0.1

nodelay

--

true

0

false

PMID: 17904888,15064760 The dual role of TRIF in both IFN-b gene expression and NF-kB activation can be further explained by the identification of kinase receptor interacting protein (RIP)-1

Go back
658.0, 718.0
19.0, 19.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m41*m42*0.1

nodelay

--

true

0

false

PMID: 17904888 Hence RIP-1 mediates the NF-kB activating arm of TRIF mediated TLR3 function.

Go back
570.0, 694.0
19.0, 19.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c78 : 1
stoichiometry:c76 : 1
stoichiometry:c79 : 1

m19305*m1599*m10*0.1

nodelay

--

true

0

false

PMID: 17904888 TLR3 ligation can activate IRF-3 via TRIF, and involves the kinases TBK1 and IKK-i or epsilon.

Go back
617.0, 709.0
21.0, 21.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m44*m977*0.1

nodelay

--

true

0

false

PMID: 17904888,12692549,16127453,16177806,14703513 ,16153868 Both the TLR3 associated adapter TRIF, and RIG-I adaptor CARDIF , have been immunoprecipitated with IKK-i/epsilon or TBK1, and these kinases have been shown to directly phosphorylate IRF-3 at Ser386, leading to its dimerisation

Go back
510.0, 770.0
19.0, 19.0

p29

p29

cso30:i:ME_Dimerization

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c83 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 17904888,12692549,16127453,16177806,14703513 ,16153868 Both the TLR3 associated adapter TRIF, and RIG-I adaptor CARDIF , have been immunoprecipitated with IKK-i/epsilon or TBK1, and these kinases have been shown to directly phosphorylate IRF-3 at Ser386, leading to its dimerisation PMID: 17904888 Subsequent experiments showed that TLR3 mediated signalling to IRF-3 requires both TBK1 and PI3K for full phosphorylation of IRF-3 at Ser396, possibly via the PI3K target Akt, and hence formation of IRF-3 dimers and full induction of IRF responsive genes, such as ISG56.

Go back
513.0, 357.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m14*m980*0.1

nodelay

--

true

0

false

PMID: 17904888,12900525 Further studies have demonstrated that in pDCs and HEK293 cells, TLR9 ligation causes the adaptor MyD88 to interact with the transcription factor IRF-7 and induce IFN-a gene expression.

Go back
539.0, 1091.0
18.0, 18.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17904888 Lung fibroblasts, and macrophages from TRIF deficient mice also had impaired IRF-3 phosphorylation after polyIC ligation suggesting TRIF induces IFN-b via the transcription factor IRF-3.

Go back
647.0, 1083.0
17.0, 17.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 17904888 Lung fibroblasts, and macrophages from TRIF deficient mice also had impaired IRF-3 phosphorylation after polyIC ligation suggesting TRIF induces IFN-b via the transcription factor IRF-3.

Go back
434.0, 622.0
19.0, 19.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m39*m977*0.1

nodelay

--

true

0

false

PMID: 17904888 RNA helicases RIG-I and MDA recognise intracellular viral dsRNA or ssRNA and activate NF-kB via IKK-b, or IRF-3 via TBK1, IKK-ior epsilon.

Go back
309.0, 389.0
21.0, 21.0

p21

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c91 : 1

m26*m48*0.1

nodelay

--

true

0

false

PMID: 17904888 This complex then makes contact with a kinase complex, which includes TANK, TANK binding kinase 1 (TBK1) and IKK-i/epsilon.

Go back
230.0, 626.0
19.0, 19.0

p32

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m49*m977*0.1

nodelay

--

true

0

false

PMID: 17904888 RNA helicases RIG-I and MDA recognise intracellular viral dsRNA or ssRNA and activate NF-kB via IKK-b, or IRF-3 via TBK1, IKK-ior epsilon.

Go back
347.0, 599.0
17.0, 17.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c95 : 1
stoichiometry:c97 : 1

m207*m26*0.1

nodelay

--

true

0

false

Go back
510.0, 806.0
19.0, 19.0

p32

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m63*m42*0.1

nodelay

--

true

0

false

PMID: 17904888 RNA helicases RIG-I and MDA recognise intracellular viral dsRNA or ssRNA and activate NF-kB via IKK-b, or IRF-3 via TBK1, IKK-ior epsilon.

Go back
311.0, 575.0
17.0, 17.0

p35

p37

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m38*m207*0.1

nodelay

--

true

0

false

Go back
522.0, 870.0
19.0, 19.0

p32

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c105 : 1

m42*m64*0.1

nodelay

--

true

0

false

PMID: 17904888 RNA helicases RIG-I and MDA recognise intracellular viral dsRNA or ssRNA and activate NF-kB via IKK-b, or IRF-3 via TBK1, IKK-ior epsilon.

Go back
827.0, 779.0
17.0, 17.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c113 : 1
stoichiometry:c110 : 1

m977*m67*0.1

nodelay

--

true

0

false

PMID: 17904888 Subsequent experiments showed that TLR3 mediated signalling to IRF-3 requires both TBK1 and PI3K for full phosphorylation of IRF-3 at Ser396, possibly via the PI3K target Akt, and hence formation of IRF-3 dimers and full induction of IRF responsive genes, such as ISG56.

Go back
374.0, 1018.0
19.0, 19.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m17*m15*0.1

nodelay

--

true

0

false

PMID: 17904888,12900525 Further studies have demonstrated that in pDCs and HEK293 cells, TLR9 ligation causes the adaptor MyD88 to interact with the transcription factor IRF-7 and induce IFN-a gene expression. PMID: 17904888 This process involves a kinase complex containing TRAF6 and the IL-1 receptor associated kinase (IRAK). PMID: 17904888,15767370 In the different cell types, different family members of IRAK appear to be important, in pDCs, IRAK-1 was required however in HEK cells IRAK-4 was responsible

Go back
895.0, 715.0
17.0, 17.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m35*m66*0.1

nodelay

--

true

0

false

PMID: 17904888 Subsequent experiments showed that TLR3 mediated signalling to IRF-3 requires both TBK1 and PI3K for full phosphorylation of IRF-3 at Ser396, possibly via the PI3K target Akt, and hence formation of IRF-3 dimers and full induction of IRF responsive genes, such as ISG56.

Go back
407.0, 1103.0
17.0, 17.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c127 : 1
stoichiometry:c115 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17904888 Subsequent experiments showed that TLR3 mediated signalling to IRF-3 requires both TBK1 and PI3K for full phosphorylation of IRF-3 at Ser396, possibly via the PI3K target Akt, and hence formation of IRF-3 dimers and full induction of IRF responsive genes, such as ISG56. PMID: 17904888 Importantly, ISG56 expression could be inhibited by wortmannin and LY294002, potent inhibitors of PI3K, and IRF-3 association with CBP and the ISG56 promoter was inhibited, but nuclear translocation of IRF-3 was not inhibited.

Go back
703.0, 1043.0
17.0, 17.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c117 : 1

m46*m2282*0.1

nodelay

--

true

0

false

PMID: 17904888 Subsequent experiments showed that TLR3 mediated signalling to IRF-3 requires both TBK1 and PI3K for full phosphorylation of IRF-3 at Ser396, possibly via the PI3K target Akt, and hence formation of IRF-3 dimers and full induction of IRF responsive genes, such as ISG56.

Go back
498.0, 906.0
19.0, 19.0

p43

p43

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17904888 Subsequent experiments showed that TLR3 mediated signalling to IRF-3 requires both TBK1 and PI3K for full phosphorylation of IRF-3 at Ser396, possibly via the PI3K target Akt, and hence formation of IRF-3 dimers and full induction of IRF responsive genes, such as ISG56.

Go back
487.0, 991.0
17.0, 17.0

p44

p44

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c125 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c126 : 1

m70*m73*0.1

nodelay

--

true

0

false

PMID: 17904888 Subsequent experiments showed that TLR3 mediated signalling to IRF-3 requires both TBK1 and PI3K for full phosphorylation of IRF-3 at Ser396, possibly via the PI3K target Akt, and hence formation of IRF-3 dimers and full induction of IRF responsive genes, such as ISG56.

Go back
943.0, 327.0
17.0, 17.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m18*m19940*0.1

nodelay

--

true

0

false

PMID: 17904888,14530357 The TLR7 ligand imiquimod induces IFN-a in pDCs and monocytes

Go back
911.0, 391.0
17.0, 17.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19*m20*0.1

nodelay

--

true

0

false

PMID: 17904888 TLR7 ligation involves a signalling pathway consisting of MyD88, TRAF6 and IRAK-1, and this complex leads to IRF-5 and IRF-7 activation in HEK293 cells.

Go back
889.0, 561.0
21.0, 21.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m21*m979*0.1

nodelay

--

true

0

false

PMID: 17904888 TLR7 ligation involves a signalling pathway consisting of MyD88, TRAF6 and IRAK-1, and this complex leads to IRF-5 and IRF-7 activation in HEK293 cells.

Go back
589.0, 445.0
21.0, 21.0

p7

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m21*m980*0.1

nodelay

--

true

0

false

PMID: 17904888 TLR7 ligation involves a signalling pathway consisting of MyD88, TRAF6 and IRAK-1, and this complex leads to IRF-5 and IRF-7 activation in HEK293 cells.

Go back
309.0, 49.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 17904888,17038589 RIG-I recognises dsRNA and also is thought to associate with 50-triphosphorylated ssRNA derived from virally infected cells

Go back
717.0, 76.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.3613783558804, 450.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.0, 818.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
331.8450720363748, 282.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
245.0, 598.3224604195036

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 592.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
547.536662342859, 735.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.0, 851.4401348352623

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.0, 849.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
486.0, 232.0

c107

c107

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
863.0, 538.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.0, 749.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.14115091028873, 1037.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.9944158443593, 780.2988566670789

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.0, 724.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
911.0, 732.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
851.9602975216799, 777.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
667.0, 900.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.0, 1120.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 1052.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.5047326640744, 932.8049908093875

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 916.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.17217356321294, 925.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
286.0, 890.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 997.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.8179199121401, 894.0

c121

c121

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
427.7041600751079, 829.0

c122

c122

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
723.5012653797141, 832.0

c123

c123

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
723.7262319536129, 896.0

c124

c124

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
510.0509053796172, 1012.2332154634527

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.66326300361385, 1008.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.56316647596276, 1067.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
507.8484791892388, 826.0

c128

c128

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
507.9394599447525, 892.0

c129

c129

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
968.0, 336.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 343.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
594.848442145943, 677.4585460028801

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.0, 669.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.0, 336.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.6564023547028, 342.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.0, 400.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.8623479330104, 412.4436087949382

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.7825910378433, 408.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.0, 497.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.266928480466, 213.30254601515935

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.0, 572.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
910.0, 582.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.9663209137135, 457.73330150670165

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.0, 456.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.7365962981012, 459.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
252.0, 60.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
287.0, 77.78499287831657

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.0, 70.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.0, 201.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
158.0, 212.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
711.0471404825303, 206.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
150.0, 222.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
303.0, 149.72181097535955

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 69.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.0, 142.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
341.1554175279993, 293.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
341.88812811075036, 319.33320475111276

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
334.0, 324.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
241.0, 72.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 376.0437687993774

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 369.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 292.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.0, 628.0028719586807

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 622.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.0, 470.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.0, 580.6564023547028

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.0, 574.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 720.3281261544709

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.0, 707.2639240088533

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.2063829016269, 545.9973374380425

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.5044337701482, 839.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.0, 212.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.0, 892.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.8885676102462, 885.3306017655837

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.5567561095966, 967.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.8823322690734, 1161.0784191224138

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.0, 209.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
422.0, 248.98908109083828

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 236.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.81358546742945, 278.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 421.969191326413

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.48481375160594, 376.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 302.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.0, 417.1953100279726

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
414.0, 418.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.0, 507.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.7667475481013, 478.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 72.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.0, 500.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.2455218124675, 504.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.5136810560396, 568.1870748873536

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.0, 545.5381044187371

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.2964473212105, 552.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 368.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 590.1313708498985

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 591.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.1854607369461, 648.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
685.0, 728.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 737.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.2829174186304, 554.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.0, 701.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 780.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.0, 666.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.0, 665.6996903666364

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 385.92878587894916

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.2790621242674, 667.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.0, 725.2517885436057

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.9083398852216, 730.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.0, 787.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.8539409299159, 900.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.214045989756, 1107.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.0, 1097.5141035588317

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
664.0, 1092.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 532.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.81053712924466, 647.392083582695

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 373.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.0, 641.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
296.24492101596996, 410.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.0335858293437, 584.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
256.4667648496245, 641.8718326344709

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 642.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
358.21923372386664, 385.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 618.5876987549067

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 616.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0, 808.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.4593814036235, 732.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back