_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e2
_enti_e4
_enti_e3
_enti_e55
_enti_e59
_enti_e53
_enti_e56
_enti_e54
_enti_e51
_enti_e50
_enti_e52
_enti_e57
_enti_e61
_enti_e58
_enti_e62
_enti_e60
BCL2L1(Bcl-xL)_enti_G011271
BCL2L1(Bcl-xL)
g2_fact_g2
g1_fact_g1
g2_fact_g12
g2_fact_g13
p4_propro_p4
PMID: 17905508
those with a short prodomain (procaspase-3, -6 and -7) exist in the cells as dimers that require proteolysis at internal aspartate residues to generate two large and two small subunits whose heterodimerization forms the active enzyme.
c10 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
c11 cso30:c:InputProcess connector
p5_propro_p5
PMID: 17905508
those with a short prodomain (procaspase-3, -6 and -7) exist in the cells as dimers that require proteolysis at internal aspartate residues to generate two large and two small subunits whose heterodimerization forms the active enzyme.
c13 cso30:c:InputProcess connector
c12 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 17905508
Activation of specific caspases in response to Epo in erythroid precursors leads to the specific cleavage of cellular targets such as PARP1, Acinus and Lamin B whereas the key differentiation- involved transcription factor GATA-1 is protected from cleavage by HSP70.
c116 cso30:c:OutputProcess connector
c112 cso30:c:InputAssociation connector
c115 cso30:c:InputProcess connector
p48_propro_p48
PMID: 17905508
The RIP1 cleavage generates a fragment that prevents the sustained activation of NF-kappaB, which is observed in monocytes undergoing differentiation into dendritic cells, and contributes to the down-regulation of NF-kappaB that characterizes the differentiation of monocytes into macrophage.
c135 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 17905508
The growth factor M-CSF/CSF-1 is a disulfide-linked homodimer that binds to CSF-1 receptor, stabilizes its non-covalent dimerization, activates its kinase activity and stimulates its tyrosine phosphorylation.
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 17905508, 17047155
In response to M-CSF/CSF-1, procaspase-8 interacts with the adaptor molecule FADD (Fas- Associated Death Domain), the serine threonine kinase RIP1 and the long and short isoforms of FLIP.
c122 cso30:c:InputProcess connector
c123 cso30:c:OutputProcess connector
c121 cso30:c:InputProcess connector
p55_propro_p55
PMID: 17905508, 12966146
This limited phosphorylation induces the covalent dimerization of the receptor through disulfide binding, which activates a second wave of tyrosine phosphorylation of the receptor and its interaction with downstream signaling molecules that include phosphatidylinositol- 3-kinases, extracellular-signal-related kinases and Src kinases.
c158 cso30:c:InputProcess connector
c159 cso30:c:InputProcess connector
c160 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 17905508, 8343951
The binding of one Epo molecule to its receptor, which exists as a preformed dimer or dimerizes upon Epo binding, induces a conformational change that activated the constitutively associated JAK2 (Janus family tyrosine protein kinase 2) by transphosphorylation.
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 17905508
Epo starvation induces Hsp70 nucleus export and exposes GATA-1 to caspase-mediated cleavage.
c99 cso30:c:OutputProcess connector
c98 cso30:c:InputProcess connector
p51_propro_p51
PMID: 17905508, 16636047
This approach, performed in the U937 cell line model, identified several proteins whose caspase-mediated cleavage was confirmed in primary monocytes exposed to M-CSF. These target proteins include p21-activated kinase-2, Nucleophosmin, a-Tubulin, Vinculin, Plasminogen Activator Inhibitory-2 (PAI-2), and several proteins of the hnRNP family.
c145 cso30:c:InputAssociation connector
c148 cso30:c:InputProcess connector
c149 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 17905508
One of the soluble molecules subsequently released in the cytosol is cytochrome c, which induces Apaf-1 (apoptotic protease-activating factor 1) oligomerization and procaspase-9 recruitment and activation in the so-called apoptosome.
c34 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
c35 cso30:c:InputProcess connector
p45_propro_p45
PMID: 17905508, 17047155
In response to M-CSF/CSF-1, procaspase-8 interacts with the adaptor molecule FADD (Fas- Associated Death Domain), the serine threonine kinase RIP1 and the long and short isoforms of FLIP.
c124 cso30:c:InputProcess connector
c127 cso30:c:InputProcess connector
c131 cso30:c:InputProcess connector
c128 cso30:c:InputProcess connector
c126 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 17905508
In turn, JAK2 molecules phosphorylate the eight tyrosine residues in the cytoplasmic domain of the Epo receptor, which then serve as docking sites for signaling molecules that contain Src homology 2 (SH2) domains such as STAT5 (Signal Transducer and Activator of Transcription 5), leading to its homodimerization and activation through phosphorylation.
c55 cso30:c:OutputProcess connector
c54 cso30:c:InputProcess connector
p42_propro_p42
PMID: 17905508
Activation of specific caspases in response to Epo in erythroid precursors leads to the specific cleavage of cellular targets such as PARP1, Acinus and Lamin B whereas the key differentiation- involved transcription factor GATA-1 is protected from cleavage by HSP70.
c113 cso30:c:InputAssociation connector
c118 cso30:c:OutputProcess connector
c117 cso30:c:InputProcess connector
p7_propro_p7
PMID: 17905508, 14976035, 12438425, 11208865
Caspase-3, together with caspase-9, -7 and -2, are transiently activated during erythroid differentiation induced by Epo and caspase inhibition completely inhibits erythroid differentiation at the basophilic erythroblast stage.
c82 cso30:c:InputAssociation connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 17905508
those with a short prodomain (procaspase-3, -6 and -7) exist in the cells as dimers that require proteolysis at internal aspartate residues to generate two large and two small subunits whose heterodimerization forms the active enzyme.
c7 cso30:c:OutputProcess connector
c2 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 17905508
Interaction of a death receptor such as Fas (CD95), with its ligand, triggers formation of a death-inducing signaling complex (DISC), including the adaptor molecule FADD, which in turn recruits procaspase-8.
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c28 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 17905508
Interaction of a death receptor such as Fas (CD95), with its ligand, triggers formation of a death-inducing signaling complex (DISC), including the adaptor molecule FADD, which in turn recruits procaspase-8.
c29 cso30:c:OutputProcess connector
c30 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
p9_propro_p9
PMID: 17905508
One of the soluble molecules subsequently released in the cytosol is cytochrome c, which induces Apaf-1 (apoptotic protease-activating factor 1) oligomerization and procaspase-9 recruitment and activation in the so-called apoptosome.
c37 cso30:c:OutputProcess connector
c24 cso30:c:InputProcess connector
p46_propro_p46
PMID: 17905508
Caspase-8 is activated in response to M-CSF that induces the formation of a multimolecular platform in which FADD, RIP1 and FLIP were identified.
c130 cso30:c:OutputProcess connector
c125 cso30:c:InputProcess connector
p31_propro_p31
PMID: 17905508
Along erythroid differentiation, activated caspase-3 and, to a lower extent, caspase-7, are found in the nucleus where they co-localize with GATA-1 but this transcription factor is protected from caspase-mediated proteolysis through interaction with the chaperone heat shock protein Hsp70.
c86 cso30:c:InputProcess connector
c88 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 17905508, 16636047
This approach, performed in the U937 cell line model, identified several proteins whose caspase-mediated cleavage was confirmed in primary monocytes exposed to M-CSF. These target proteins include p21-activated kinase-2, Nucleophosmin, a-Tubulin, Vinculin, Plasminogen Activator Inhibitory-2 (PAI-2), and several proteins of the hnRNP family.
c152 cso30:c:InputProcess connector
c146 cso30:c:InputAssociation connector
c150 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 17905508
Other active signaling molecules recruited by the phosphorylated Epo receptor include the phopshatidylinositol- 3 kinase that, together with STAT5, promote erythroid cell survival, and son of sevenless protein recruited through the adaptor protein Grb-2 to activate the RAS/MAP (mitogen- activated protein) kinase pathway, thereby promoting proliferation.
c72 cso30:c:InputAssociation connector
c68 cso30:c:InputProcess connector
c69 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 17905508
Along erythroid differentiation, activated caspase-3 and, to a lower extent, caspase-7, are found in the nucleus where they co-localize with GATA-1 but this transcription factor is protected from caspase-mediated proteolysis through interaction with the chaperone heat shock protein Hsp70.
c96 cso30:c:OutputProcess connector
c95 cso30:c:InputProcess connector
c94 cso30:c:InputProcess connector
p33_propro_p33
PMID: 17905508
Procaspase-8 is then activated by proximity-induced dimerization within this oligomeric recruitment complex, which in turn activates the caspase cascade.
c31 cso30:c:InputProcess connector
c92 cso30:c:OutputProcess connector
c48 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 17905508, 12966146
This limited phosphorylation induces the covalent dimerization of the receptor through disulfide binding, which activates a second wave of tyrosine phosphorylation of the receptor and its interaction with downstream signaling molecules that include phosphatidylinositol- 3-kinases, extracellular-signal-related kinases and Src kinases.
c107 cso30:c:InputProcess connector
c108 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 17905508, 16636047
This approach, performed in the U937 cell line model, identified several proteins whose caspase-mediated cleavage was confirmed in primary monocytes exposed to M-CSF. These target proteins include p21-activated kinase-2, Nucleophosmin, a-Tubulin, Vinculin, Plasminogen Activator Inhibitory-2 (PAI-2), and several proteins of the hnRNP family.
c147 cso30:c:InputAssociation connector
c153 cso30:c:InputProcess connector
c151 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 17905508, 8343951
The binding of one Epo molecule to its receptor, which exists as a preformed dimer or dimerizes upon Epo binding, induces a conformational change that activated the constitutively associated JAK2 (Janus family tyrosine protein kinase 2) by transphosphorylation.
c39 cso30:c:InputProcess connector
c45 cso30:c:InputProcess connector
c40 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 17905508
Activation of specific caspases in response to Epo in erythroid precursors leads to the specific cleavage of cellular targets such as PARP1, Acinus and Lamin B whereas the key differentiation- involved transcription factor GATA-1 is protected from cleavage by HSP70.
c119 cso30:c:InputProcess connector
c114 cso30:c:InputAssociation connector
c120 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 17905508
PAK-2 can be activated by the monomeric G proteins Cdc42 and Rac that, in their GTP-bound state, bind to a conserved region within the Nterminal domain of PAKs to release inhibition of the catalytic site by an overlapping autoinhibitory domain.
c164 cso30:c:OutputProcess connector
c163 cso30:c:InputProcess connector
c166 cso30:c:InputAssociation connector
p49_propro_p49
PMID: 17905508
A cleavage fragment of RIP1, generated by active caspase-8, contributes to the down-regulation of NF-kappaB whereas caspase-3, activated downstream of caspase-8, cleaves other target proteins such as PAK2 and nucleophosmin that contribute to the differentiation.
c140 cso30:c:OutputProcess connector
c139 cso30:c:InputProcess connector
c141 cso30:c:InputAssociation connector
p21_propro_p21
PMID: 17905508
In turn, JAK2 molecules phosphorylate the eight tyrosine residues in the cytoplasmic domain of the Epo receptor, which then serve as docking sites for signaling molecules that contain Src homology 2 (SH2) domains such as STAT5 (Signal Transducer and Activator of Transcription 5), leading to its homodimerization and activation through phosphorylation.
c57 cso30:c:OutputProcess connector
c56 cso30:c:InputProcess connector
p37_propro_p37
PMID: 17905508
The growth factor M-CSF/CSF-1 is a disulfide-linked homodimer that binds to CSF-1 receptor, stabilizes its non-covalent dimerization, activates its kinase activity and stimulates its tyrosine phosphorylation.
c103 cso30:c:InputProcess connector
c102 cso30:c:InputProcess connector
c104 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 17905508
those with a short prodomain (procaspase-3, -6 and -7) exist in the cells as dimers that require proteolysis at internal aspartate residues to generate two large and two small subunits whose heterodimerization forms the active enzyme.
c14 cso30:c:InputProcess connector
c15 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 17905508
Other active signaling molecules recruited by the phosphorylated Epo receptor include the phopshatidylinositol- 3 kinase that, together with STAT5, promote erythroid cell survival, and son of sevenless protein recruited through the adaptor protein Grb-2 to activate the RAS/MAP (mitogen- activated protein) kinase pathway, thereby promoting proliferation.
c62 cso30:c:InputProcess connector
c63 cso30:c:OutputProcess connector
c61 cso30:c:InputProcess connector
p3_propro_p3
PMID: 17905508
those with a short prodomain (procaspase-3, -6 and -7) exist in the cells as dimers that require proteolysis at internal aspartate residues to generate two large and two small subunits whose heterodimerization forms the active enzyme.
PMID: 17905508, 14976035, 12438425, 11208865
Caspase-3, together with caspase-9, -7 and -2, are transiently activated during erythroid differentiation induced by Epo and caspase inhibition completely inhibits erythroid differentiation at the basophilic erythroblast stage.
c8 cso30:c:OutputProcess connector
c19 cso30:c:InputAssociation connector
c3 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 17905508, 12966146
This limited phosphorylation induces the covalent dimerization of the receptor through disulfide binding, which activates a second wave of tyrosine phosphorylation of the receptor and its interaction with downstream signaling molecules that include phosphatidylinositol- 3-kinases, extracellular-signal-related kinases and Src kinases.
c157 cso30:c:OutputProcess connector
c156 cso30:c:InputProcess connector
p32_propro_p32
PMID: 17905508
Along erythroid differentiation, activated caspase-3 and, to a lower extent, caspase-7, are found in the nucleus where they co-localize with GATA-1 but this transcription factor is protected from caspase-mediated proteolysis through interaction with the chaperone heat shock protein Hsp70.
c87 cso30:c:InputProcess connector
c89 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 17905508, 12966146
This limited phosphorylation induces the covalent dimerization of the receptor through disulfide binding, which activates a second wave of tyrosine phosphorylation of the receptor and its interaction with downstream signaling molecules that include phosphatidylinositol- 3-kinases, extracellular-signal-related kinases and Src kinases.
c111 cso30:c:OutputProcess connector
c109 cso30:c:InputProcess connector
c110 cso30:c:InputProcess connector
p12_propro_p12
PMID: 17905508
One of the soluble molecules subsequently released in the cytosol is cytochrome c, which induces Apaf-1 (apoptotic protease-activating factor 1) oligomerization and procaspase-9 recruitment and activation in the so-called apoptosome.
c33 cso30:c:OutputProcess connector
c32 cso30:c:InputProcess connector
c21 cso30:c:InputAssociation connector
p30_propro_p30
PMID: 17905508, 14976035, 12438425, 11208865
Caspase-3, together with caspase-9, -7 and -2, are transiently activated during erythroid differentiation induced by Epo and caspase inhibition completely inhibits erythroid differentiation at the basophilic erythroblast stage.
c84 cso30:c:OutputProcess connector
c83 cso30:c:InputProcess connector
c85 cso30:c:InputAssociation connector
p58_propro_p58
PMID: 17905508
Interaction of a death receptor such as Fas (CD95), with its ligand, triggers formation of a death-inducing signaling complex (DISC), including the adaptor molecule FADD, which in turn recruits procaspase-8.
c27 cso30:c:InputProcess connector
c167 cso30:c:InputProcess connector
c168 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 17905508, 10359572, 10428030
In Epo-deprived as well as Fas-ligand treated immature erythroblasts, activated caspases cleave the transcription factor GATA-1. This transcription factor mediates Epo-induced up-regulation of the anti-apoptotic protein Bcl-XL.
c74 cso30:c:InputAssociation connector
c169 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 17905508
In turn, JAK2 molecules phosphorylate the eight tyrosine residues in the cytoplasmic domain of the Epo receptor, which then serve as docking sites for signaling molecules that contain Src homology 2 (SH2) domains such as STAT5 (Signal Transducer and Activator of Transcription 5), leading to its homodimerization and activation through phosphorylation.
c49 cso30:c:InputProcess connector
c50 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 17905508, 10359572, 10428030
In Epo-deprived as well as Fas-ligand treated immature erythroblasts, activated caspases cleave the transcription factor GATA-1. This transcription factor mediates Epo-induced up-regulation of the anti-apoptotic protein Bcl-XL.
PMID: 17905508, 14976035, 12438425, 11208865
Caspase-3, together with caspase-9, -7 and -2, are transiently activated during erythroid differentiation induced by Epo and caspase inhibition completely inhibits erythroid differentiation at the basophilic erythroblast stage.
c75 cso30:c:InputProcess connector
c90 cso30:c:InputAssociation connector
c77 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 17905508
PAK-2 can be activated by the monomeric G proteins Cdc42 and Rac that, in their GTP-bound state, bind to a conserved region within the Nterminal domain of PAKs to release inhibition of the catalytic site by an overlapping autoinhibitory domain.
c162 cso30:c:OutputProcess connector
c165 cso30:c:InputAssociation connector
c161 cso30:c:InputProcess connector
p47_propro_p47
PMID: 17905508
Interestingly, RIP1 is cleaved by caspase-8 in the multimolecular platform.
PMID: 17905508, 17047155, 12393560
We also observed that another well identified caspase target, Lamin B, remained uncleaved whereas three other caspase targets, namely RIP1, FLIP and Acinus, were cleaved.
c133 cso30:c:OutputProcess connector
c134 cso30:c:OutputProcess connector
c155 cso30:c:OutputProcess connector
c132 cso30:c:InputProcess connector
c154 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 17905508, 8343951
The binding of one Epo molecule to its receptor, which exists as a preformed dimer or dimerizes upon Epo binding, induces a conformational change that activated the constitutively associated JAK2 (Janus family tyrosine protein kinase 2) by transphosphorylation.
c42 cso30:c:OutputProcess connector
c41 cso30:c:InputProcess connector
p25_propro_p25
PMID: 17905508
Other active signaling molecules recruited by the phosphorylated Epo receptor include the phopshatidylinositol- 3 kinase that, together with STAT5, promote erythroid cell survival, and son of sevenless protein recruited through the adaptor protein Grb-2 to activate the RAS/MAP (mitogen- activated protein) kinase pathway, thereby promoting proliferation.
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
c67 cso30:c:InputAssociation connector
p50_propro_p50
PMID: 17905508
A cleavage fragment of RIP1, generated by active caspase-8, contributes to the down-regulation of NF-kappaB whereas caspase-3, activated downstream of caspase-8, cleaves other target proteins such as PAK2 and nucleophosmin that contribute to the differentiation.
c142 cso30:c:InputProcess connector
c144 cso30:c:InputAssociation connector
c143 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 17905508, 8343951
The binding of one Epo molecule to its receptor, which exists as a preformed dimer or dimerizes upon Epo binding, induces a conformational change that activated the constitutively associated JAK2 (Janus family tyrosine protein kinase 2) by transphosphorylation.
c44 cso30:c:OutputProcess connector
c38 cso30:c:InputProcess connector
c43 cso30:c:InputProcess connector
p27_propro_p27
PMID: 17905508, 10359572, 10428030
In Epo-deprived as well as Fas-ligand treated immature erythroblasts, activated caspases cleave the transcription factor GATA-1. This transcription factor mediates Epo-induced up-regulation of the anti-apoptotic protein Bcl-XL.
c76 cso30:c:InputProcess connector
c73 cso30:c:InputAssociation connector
c78 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 17905508
In turn, JAK2 molecules phosphorylate the eight tyrosine residues in the cytoplasmic domain of the Epo receptor, which then serve as docking sites for signaling molecules that contain Src homology 2 (SH2) domains such as STAT5 (Signal Transducer and Activator of Transcription 5), leading to its homodimerization and activation through phosphorylation.
c52 cso30:c:InputProcess connector
c51 cso30:c:InputProcess connector
c53 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 17905508
Other active signaling molecules recruited by the phosphorylated Epo receptor include the phopshatidylinositol- 3 kinase that, together with STAT5, promote erythroid cell survival, and son of sevenless protein recruited through the adaptor protein Grb-2 to activate the RAS/MAP (mitogen- activated protein) kinase pathway, thereby promoting proliferation.
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
c58 cso30:c:InputProcess connector
p24_propro_p24
PMID: 17905508
Other active signaling molecules recruited by the phosphorylated Epo receptor include the phopshatidylinositol- 3 kinase that, together with STAT5, promote erythroid cell survival, and son of sevenless protein recruited through the adaptor protein Grb-2 to activate the RAS/MAP (mitogen- activated protein) kinase pathway, thereby promoting proliferation.
c65 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c66 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 17905508
Procaspase-8 is then activated by proximity-induced dimerization within this oligomeric recruitment complex, which in turn activates the caspase cascade.
c23 cso30:c:InputProcess connector
c91 cso30:c:OutputProcess connector
p1_propro_p1
PMID: 17905508
those with a short prodomain (procaspase-3, -6 and -7) exist in the cells as dimers that require proteolysis at internal aspartate residues to generate two large and two small subunits whose heterodimerization forms the active enzyme.
PMID: 17905508, 14976035, 12438425, 11208865
Caspase-3, together with caspase-9, -7 and -2, are transiently activated during erythroid differentiation induced by Epo and caspase inhibition completely inhibits erythroid differentiation at the basophilic erythroblast stage.
c1 cso30:c:InputProcess connector
c138 cso30:c:InputAssociation connector
c5 cso30:c:OutputProcess connector
c22 cso30:c:InputAssociation connector
c4 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 17905508
In the presence of Epo, Hsp70 migrates in the nucleus when caspases are activated and protect GATA-1 from caspase-mediated cleavage.
c100 cso30:c:OutputProcess connector
c97 cso30:c:InputProcess connector
c101 cso30:c:InputAssociation connector
EpoR: Jak2_enti_e22
EpoR: Jak2
M-CSF: M-CSF-1-R [p} dimer_enti_e42
M-CSF: M-CSF-1-R [p} dimer
M-CSF-1-R_enti_MO000007995
M-CSF-1-R
FLIP-L_enti_MO000017945
FLIP-L
Ras_enti_MO000016736
Ras
Epo: EpoR dimer {p}: Jak2 {p}: Grb-2: Sos_enti_e30
Epo: EpoR dimer {p}: Jak2 {p}: Grb-2: Sos
Cytochrome C_enti_MO000016985
Cytochrome C
2(small subunit of caspase-7)_enti_e16
2(small subunit of caspase-7)
2(small subunit of caspase-6)_enti_e12
2(small subunit of caspase-6)
Epo: EpoR dimer {p}: Jak2 {p}: STAT5 dimer_enti_e26
Epo: EpoR dimer {p}: Jak2 {p}: STAT5 dimer
proCaspase-3_enti_MO000017671
proCaspase-3
M-CSF: M-CSF-1-R [p} dimer: Caspase-8_enti_e63
M-CSF: M-CSF-1-R [p} dimer: Caspase-8
Caspase-3_enti_MO000016924
Caspase-3
PAI-2 remnants_enti_e71
Apaf-1 olgomer: proCaspase-9_enti_e19
Apaf-1 olgomer: proCaspase-9
Epo: EpoR dimer: Jak2 {p}_enti_e24
Epo: EpoR dimer: Jak2 {p}
PARP1 remnants_enti_e45
Hsp70 {nucleolus}_enti_MO000021614
Hsp70 {nucleolus}
Caspase-9_enti_MO000016987
Caspase-9
Epo: EpoR: Jak2_enti_e20
Epo: EpoR: Jak2
Caspase-7_enti_e36
Caspase-7
2(small subunit of caspase-3)_enti_e11
2(small subunit of caspase-3)
Hsp70_enti_e38
Hsp70
Apaf-1 oligomer_enti_e18
Apaf-1 oligomer
Ras {activated}_enti_e32
Ras {activated}
Epo: EpoR dimer {p}: Jak2 {p}: Grb-2_enti_e29
Epo: EpoR dimer {p}: Jak2 {p}: Grb-2
MAPK_enti_MO000016936
MAPK
vinculin remnants_enti_e70
RIP1_enti_MO000000065
RIP1
proCaspase-8_enti_MO000017669
proCaspase-8
Grb-2_enti_MO000000012
Grb-2
Acinus_enti_MO000097692
Acinus
nucleophosmin {activated}_enti_e68
nucleophosmin {activated}
death receptor ligand: Fas: FADD: proCaspase-8_enti_e79
death receptor ligand: Fas: FADD: proCaspase-8
MAPK {activated}_enti_e31
MAPK {activated}
Lamin-B remnants_enti_e47
Epo: EpoR dimer {p}: Jak2 {p}: STAT5 dimer {p}: PI3K_enti_e28
Epo: EpoR dimer {p}: Jak2 {p}: STAT5 dimer {p}: PI3K
2(large subunit of caspase-3)_enti_e5
2(large subunit of caspase-3)
FADD_enti_MO000016899
FADD
proCaspase-6_enti_MO000032136
proCaspase-6
death receptor ligand: Fas: FADD_enti_e78
death receptor ligand: Fas: FADD
Caspase-3_enti_e35
Caspase-3
Rac: GTP_enti_e77
Rac: GTP
proCaspase-7_enti_MO000018906
proCaspase-7
proCaspase-2_enti_MO000017670
proCaspase-2
GATA-1_enti_MO000032476
GATA-1
nucleophosmin_enti_MO000045126
nucleophosmin
Cdc42:GTP_enti_MO000019718
Cdc42:GTP
GATA-1 {activated}_enti_e33
GATA-1 {activated}
M-CSF: M-CSF-1-R [p} dimer: ERK_enti_e76
M-CSF: M-CSF-1-R [p} dimer: ERK
Caspase-2_enti_MO000016909
Caspase-2
death receptor ligand: Fas_enti_e15
death receptor ligand: Fas
Caspase-6_enti_MO000017602
Caspase-6
M-CSF_enti_MO000000100
M-CSF
Sos_enti_MO000016777
Sos
Hsp70 {nucleolus}: GATA-1_enti_e37
Hsp70 {nucleolus}: GATA-1
Caspase-7_enti_MO000017603
Caspase-7
death receptor ligand_enti_e14
death receptor ligand
alpha-tubulin remnants_enti_e69
M-CSF: M-CSF-1-R [p} dimer: PI3K_enti_e40
M-CSF: M-CSF-1-R [p} dimer: PI3K
Epo_enti_MO000017066
Epo
death receptor ligand: Fas: FADD: proCaspase-8_enti_e17
death receptor ligand: Fas: FADD: proCaspase-8
EpoR_enti_MO000000092
EpoR
M-CSF: M-CSF-1-R [p} dimer: proCaspase-8_enti_e48
M-CSF: M-CSF-1-R [p} dimer: proCaspase-8
Jak2_enti_MO000000146
Jak2
M-CSF: M-CSF-1-R [p} dimer_enti_e75
M-CSF: M-CSF-1-R [p} dimer
proCaspase-9_enti_MO000017811
proCaspase-9
PAI-2_enti_e72
PAI-2
Epo: EpoR dimer {p}: Jak2 {p}: STAT5_enti_e25
Epo: EpoR dimer {p}: Jak2 {p}: STAT5
FLIP-S remnant_enti_e74
alpha-tubulin_enti_MO000019238
alpha-tubulin
PARP1_enti_e43
PARP1
Fas_enti_MO000004927
Fas
PI3K_enti_MO000000030
PI3K
M-CSF: M-CSF-1-R [p} dimer: Caspase-8: FADD: RIP1: FLIP-L: FLIP-S_enti_e49
M-CSF: M-CSF-1-R [p} dimer: Caspase-8: FADD: RIP1: FLIP-L: FLIP-S
NF-kappaB_enti_MO000000058
NF-kappaB
Acinus remnants_enti_e46
FLIP-L remnant_enti_e73
M-CSF: M-CSF-1-R [p}_enti_e41
M-CSF: M-CSF-1-R [p}
Epo: EpoR dimer: Jak2_enti_e21
Epo: EpoR dimer: Jak2
PAK2_enti_MO000017616
PAK2
FLIP-S_enti_MO000017946
FLIP-S
vinculin_enti_MO000020340
vinculin
Lamin-B_enti_e44
Lamin-B
Apaf-1_enti_MO000016986
Apaf-1
NF-kappaB {activated}_enti_e66
NF-kappaB {activated}
STAT5_enti_MO000016876
STAT5
M-CSF: M-CSF-1-R [p} dimer: Caspase-8: FADD_enti_e64
M-CSF: M-CSF-1-R [p} dimer: Caspase-8: FADD
ERK_enti_MO000000011
ERK
RIP1 fragment_enti_e65
Epo: EpoR dimer {p}: Jak2 {p}_enti_e23
Epo: EpoR dimer {p}: Jak2 {p}
2(large subunit of caspase-7)_enti_e13
2(large subunit of caspase-7)
2(large subunit of caspase-6)_enti_e6
2(large subunit of caspase-6)
Caspase-8_enti_MO000016900
Caspase-8
M-CSF: M-CSF-1-R_enti_e39
M-CSF: M-CSF-1-R
PAK2 {activated}_enti_e67
PAK2 {activated}
Epo: EpoR dimer {p}: Jak2 {p}: STAT5 dimer {p}_enti_e27
Epo: EpoR dimer {p}: Jak2 {p}: STAT5 dimer {p}