1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17913496.csml convertedTime:2009.07.01.11:08

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Immunoreceptor-like signaling by beta 2 and beta 3 integrins.
Authors Jakus Z, Fodor S, Abram CL, Lowell CA, Mocsai A.
Affiliation Department of Physiology, Semmelweis University School of Medicine, 1088Budapest, Hungary.
Abstract Although adhesion to extracellular structures is one of the most fundamentalcell biological processes, the intracellular signals triggered by integrins, themost important receptors involved, are incompletely understood. Several recentreports indicate that signaling by beta(2) and beta(3) integrins in various celltypes (neutrophils, macrophages, osteoclasts and platelets) use components ofthe signal transduction machinery of lymphocyte antigen receptors. Central tothis immunoreceptor-like signaling is the phosphorylation of immunoreceptortyrosine-based activation motif (ITAM)-containing adapters (such as DAP12 andthe Fc receptor gamma-chain) by Src-family kinases and the concomitantrecruitment of the Syk tyrosine kinase through its dual SH2 domains. These andother reports reveal an unexpected similarity between the signal-transductionmechanisms used by integrins and immune recognition receptors.
PMID 17913496
Model Abstract

Entity

MO000000011:ERK MO000000020:Rho family MO000000044:Vav-1 MO000000102:PLCgamma MO000000136:Src family MO000008301:Syk MO000017377:beta1-integrin MO000017380:beta2-integrin MO000017383:beta3-integrin MO000017772:ZAP-70 MO000017773:SLP-76 MO000017796:SLP-65 MO000018210:FcRgamma MO000021167:Vav family MO000031010:Vav-3 MO000035462:Syk{pY} MO000037486:alpha IIb-integrin MO000066771:DAP12 e1: e10: e11:alpha IIb-integrin:beta3-integrin e12:alpha V-integrin:beta3-integrin e13:beta2 integrin ligand : beta2-integrin e14:beta3-integrin ligand : beta3-integrin e15:immunoreceptor ligand: immunoreceptor {pY}2 e16:alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin e17:alpha V-integrin:beta3-integrin ligand e18:alpha V-integrin:beta3-integrin ligand: alpha V-integrin:beta3-integrin e19:alpha IIb-integrin:beta3-integrin ligand e2: e20:beta1-integrin ligand: beta1-integrin e21:beta3 integrin ligand : beta3-integrin {p}: DAP12: FcRgamma e22:beta1-integrin ligand e23:beta2 integrin ligand e24:alpha IIb-integrin ligand: alpha IIb-integrin e25:alpha IIb-integrin ligand e26:beta3-integrin ligand e27:ERK {activated} e28:immunoreceptor e29:immunoreceptor ligand e3: e30:beta2 integrin ligand : beta2-integrin {pY}2: Syk e31:beta3-integrin ligand : beta3-integrin [pY}2 e32:beta3-integrin ligand : beta3-integrin [pY}2: Syk e33:beta3 integrin ligand : beta3-integrin {p}: DAP12: FcRgamma e34:beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p} e35:beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p} e36:beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk e37:beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk e38:beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk {p} e39:beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk {p} e4: e40:beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 e41:beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 e42:beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 [p} e43:beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 {p} e44:SLP-65 {activated} e45:SLP-76 {activated} e46:Vav family {activated} e47:Vav-3 {activated} e48:PLCgamma {activated} e49:beta2 integrin ligand : beta2-integrin {pY}2: ZAP-70 e5:immunoreceptor ligand: immunoreceptor e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:beta2 integrin ligand : beta2-integrin {pY}2 e60: e61: e62: e63:beta3-integrin ligand : beta3-integrin [pY}2: ZAP-70 e64:beta1-integrin ligand: beta1-integrin {p} e65:beta1-integrin ligand: beta1-integrin {p}: ZAP-70 e66:alpha V-integrin:beta3-integrin ligand: beta3-integrin e67:alpha V-integrin:beta3-integrin ligand: beta3-integrin: Syk e68:alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin {p}: Src e69:alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin {p}: Src: Syk e7: e70:alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin: Src e71:Rho family {activated} e72:Vav-1 {activated} e73:TCR ligand : TCR e74:SLP-76 {p} e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p7 p8 p9
Model Detail
799.0, 979.0
34.0, 34.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p30

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
301.0, 825.0
30.0, 30.0

Rho family

--

MO000000020

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000020

--

Go back
808.0, 1080.0
31.0, 31.0

Vav-1

--

MO000000044

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p59

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
423.0, 815.0
34.0, 34.0

PLCgamma

--

MO000000102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p43 p44 p48

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
745.0, 309.0
30.5, 30.5

Src family

--

MO000000136

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
TRANSPATHMO000000136

--

Go back
562.0, 322.0
28.0, 28.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
227.0, 499.0
26.0, 26.0

beta1-integrin

--

MO000017377

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m2211

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017377

--

Go back
557.0, 205.0
30.0, 30.0

beta2-integrin

--

MO000017380

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m2214

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017380

--

Go back
898.0, 202.0
28.0, 28.0

beta3-integrin

--

MO000017383

cso30:c:Complex

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m2217

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017383

--

Go back
957.0, 657.0
30.0, 30.0

ZAP-70

--

MO000017772

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2529

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017772

--

Go back
415.0, 599.0
32.0, 32.0

SLP-76

--

MO000017773

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m2530

10

false

infinite

0

unit false false false
InterProIPR002965
TRANSPATHMO000017773

--

Go back
419.0, 491.0
32.0, 32.0

SLP-65

--

MO000017796

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p37 p38 p45

true true true true

csml-variable:Double

m2552

10

false

infinite

0

unit false false false
TRANSPATHMO000017796

--

Go back
817.0, 425.0
29.5, 29.5

FcRgamma

--

MO000018210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p21 p31

true true true true

csml-variable:Double

m2891

10

false

infinite

0

unit false false false
TRANSPATHMO000018210

--

Go back
422.0, 722.0
28.0, 28.0

Vav family

--

MO000021167

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p41 p42 p47

true true true true

csml-variable:Double

m5542

10

false

infinite

0

unit false false false
TRANSPATHMO000021167

--

Go back
817.0, 1173.0
30.0, 30.0

Vav-3

--

MO000031010

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p60

true true true true

csml-variable:Double

m10568

10

false

infinite

0

unit false false false
TRANSPATHMO000031010

--

Go back
584.0, 436.0
32.0, 32.0

Syk{pY}

--

MO000035462

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5 p9 p11 p13

--

true true true true

csml-variable:Double

m13959

10

false

infinite

0

unit false false false
TRANSPATHMO000035462

--

Go back
233.0, 697.0
30.0, 30.0

alpha IIb-integrin

--

MO000037486

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m15748

10

false

infinite

0

unit false false false
InterProIPR000834
TRANSPATHMO000037486

--

Go back
760.0, 372.0
31.5, 31.5

DAP12

--

MO000066771

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p21 p31

true true true true

csml-variable:Double

m41628

10

false

infinite

0

unit false false false
TRANSPATHMO000066771

--

Go back
214.75, 175.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
217.0, 188.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
230.0, 386.0
28.0, 28.0

alpha IIb-integrin:beta3-integrin

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
TRANSPATHMO000037488

--

Go back
229.0, 421.0
29.0, 29.0

alpha V-integrin:beta3-integrin

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000117932

--

Go back
613.625, 190.5
29.368563572737873, 35.9615064155974

beta2 integrin ligand : beta2-integrin

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
958.625, 171.5
27.359898350274953, 33.50191634727545

beta3-integrin ligand : beta3-integrin

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
355.625, 160.5
32.65101649725047, 39.98083652724546

immunoreceptor ligand: immunoreceptor {pY}2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
232.875, 343.5
23.09602679390714, 32.22701413103322

alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
61.5, 424.375
37.12653778558875, 24.13224956063269

alpha V-integrin:beta3-integrin ligand

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
231.875, 459.5
24.327078363002386, 33.94476050651495

alpha V-integrin:beta3-integrin ligand: alpha V-integrin:beta3-integrin

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
66.5, 388.375
34.947275922671345, 22.715729349736378

alpha IIb-integrin:beta3-integrin ligand

--

e19

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
214.75, 175.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
226.625, 531.5
26.78832694550908, 32.80203299450091

beta1-integrin ligand: beta1-integrin

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1028.875, 303.5
30.01674619196183, 41.88383189576069

beta3 integrin ligand : beta3-integrin {p}: DAP12: FcRgamma

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
66.5, 537.375
34.06854130052723, 22.144551845342704

beta1-integrin ligand

--

e22

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
610.5, 44.375
35.05272407732865, 22.784270650263622

beta2 integrin ligand

--

e23

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
232.625, 657.5
29.8993084485919, 36.61139810031661

alpha IIb-integrin ligand: alpha IIb-integrin

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
96.5, 665.375
31.71353251318101, 20.61379613356766

alpha IIb-integrin ligand

--

e25

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
953.5, 108.375
36.669595782073806, 23.835237258347977

beta3-integrin ligand

--

e26

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
799.0, 1027.0
34.0, 34.0

ERK {activated}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p30

--

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
287.0, 181.5
18.0, 45.0

immunoreceptor

--

e28

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
283.5, 47.875
32.3492444569976, 31.81009038271431

immunoreceptor ligand

--

e29

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
231.87518862352903, 193.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
511.875, 149.5
32.25, 45.0

beta2 integrin ligand : beta2-integrin {pY}2: Syk

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p17

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1015.875, 161.5
32.25, 45.0

beta3-integrin ligand : beta3-integrin [pY}2

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
827.875, 181.5
32.25, 45.0

beta3-integrin ligand : beta3-integrin [pY}2: Syk

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p20

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1029.875, 360.5
28.114929344833914, 39.23013396953569

beta3 integrin ligand : beta3-integrin {p}: DAP12: FcRgamma

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1059.875, 413.5
32.25, 45.0

beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1024.875, 471.5
30.01674619196183, 41.88383189576069

beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1025.875, 524.5
28.517388511653515, 39.791704899981646

beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1025.875, 576.5
27.90975408331804, 38.9438429069554

beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1022.875, 744.5
33.465268856670946, 46.695723986052485

beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk {p}

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1021.875, 802.5
36.50344099834832, 50.9350339511837

beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: Syk {p}

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
263.5567875770579, 223.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1019.875, 629.5
32.25, 45.0

beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1023.875, 689.5
32.25, 45.0

beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1023.875, 865.5
32.25, 45.0

beta3 integrin ligand : beta3-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 [p}

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1019.875, 921.5
32.25, 45.0

beta2 integrin ligand : beta2-integrin {p}: DAP12 {p}: FcRgamma {p}: ZAP-70 {p}

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
415.0, 555.0
32.0, 32.0

SLP-65 {activated}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000017796

--

Go back
419.0, 659.0
32.0, 32.0

SLP-76 {activated}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p39 p40 p46

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR002965
TRANSPATHMO000017773

--

Go back
418.0, 766.0
28.0, 28.0

Vav family {activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000021167

--

Go back
821.0, 1221.0
30.0, 30.0

Vav-3 {activated}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p60

--

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000031010

--

Go back
423.0, 907.0
34.0, 34.0

PLCgamma {activated}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p43 p44 p48

--

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
679.875, 185.5
32.25, 45.0

beta2 integrin ligand : beta2-integrin {pY}2: ZAP-70

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p49

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
327.75, 173.5
16.5, 45.0

immunoreceptor ligand: immunoreceptor

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p1

p4

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
309.0, 993.0
382.2744596965391, 346.68093458512993

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
350.28848912923496, 1001.2158341548634
223.5273376996523, 336.002877051707

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
313.9830935155974, 997.6271582644831
372.3082726653446, 337.4266180561632

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
314.6949640178255, 998.3390287667116
370.88453166088806, 336.002877051707

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
309.0, 993.0
382.2744596965391, 346.68093458512993

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
309.0, 993.0
382.2744596965391, 346.68093458512993

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
314.6949640178255, 998.3390287667116
370.88453166088806, 336.002877051707

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
588.0532368734513, 1135.3741004456383
23.882407833263624, 21.619863933270263

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
525.4086326773704, 1235.0359707575856
67.62769771167822, 61.220863191624616

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
309.0, 993.0
382.2744596965391, 346.68093458512993

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
743.875, 165.5
32.25, 45.0

beta2 integrin ligand : beta2-integrin {pY}2

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
399.09993924014003, 1147.0621426814864
12.1060704452733, 5.82884873290938

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
398.6956832807522, 1129.6791364278133
41.43623583724473, 74.58522450704059

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
416.07868953442585, 1178.1898515543442
6.468095350204048, 6.4680953502040595

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1023.875, 237.5
32.25, 45.0

beta3-integrin ligand : beta3-integrin [pY}2: ZAP-70

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p51

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
229.625, 570.5
28.65818196967172, 35.09165139143476

beta1-integrin ligand: beta1-integrin {p}

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
231.875, 609.5
32.25, 45.0

beta1-integrin ligand: beta1-integrin {p}: ZAP-70

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p52

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
492.625, 197.5
29.768663556073985, 36.451424762539574

alpha V-integrin:beta3-integrin ligand: beta3-integrin

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p53

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
447.875, 209.5
27.238988805285373, 38.00789135621215

alpha V-integrin:beta3-integrin ligand: beta3-integrin: Syk

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p53

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
234.5, 257.0
25.331253440998346, 35.34593503395117

alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin {p}: Src

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
235.875, 218.5
24.398100568911726, 34.0438612589466

alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin {p}: Src: Syk

--

e69

cso30:c:Complex

cso30:i:CC_Extracellular

--

p55

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
226.0, 181.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
234.875, 301.5
26.22100385391815, 36.58744723802533

alpha IIb-integrin:beta3-integrin ligand: alpha IIb-integrin:beta3-integrin: Src

--

e70

cso30:c:Complex

cso30:i:CC_Extracellular

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
353.0, 945.0
30.0, 30.0

Rho family {activated}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000000020

--

Go back
812.0, 1136.0
31.0, 31.0

Vav-1 {activated}

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
229.625, 765.5
36.619355107482086, 44.84002666222296

TCR ligand : TCR

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p62

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
301.5, 736.125
37.58603340712417, 23.17805393439324

SLP-76 {p}

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
229.0, 202.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
237.0, 223.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
287.0, 107.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m29*m30*0.1

nodelay

--

true

0

false

PMID: 17913496 Ligand binding and receptor clustering leads to phosphorylation of these tyrosines by Src-family tyrosine kinases.

Go back
163.0, 535.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c29 : 1
stoichiometry:c28 : 1

m2211*m22*0.1

nodelay

--

true

0

false

PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.

Go back
487.0, 387.0
25.0, 25.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m20*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.

Go back
1199.0, 531.0
25.0, 25.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c86 : 1
stoichiometry:c45 : 1

m37*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling. PMID: 17913496, 17086186, 10547366, 11940607 Src-family kinases are indeed involved in integrin-mediated responses, including Syk phosphorylation, in neutrophils [8], [20] and [28], macrophages [12] and [29] and platelets.

Go back
486.0, 422.0
27.0, 27.0

p13

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c43 : 1

m24*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.

Go back
164.0, 664.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m15748*m25*0.1

nodelay

--

true

0

false

PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk.

Go back
1230.0, 614.0
27.0, 27.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c87 : 1
stoichiometry:c75 : 1

m38*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling. PMID: 17913496, 17086186, 10547366, 11940607 Src-family kinases are indeed involved in integrin-mediated responses, including Syk phosphorylation, in neutrophils [8], [20] and [28], macrophages [12] and [29] and platelets.

Go back
878.0, 982.0
27.0, 27.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c89 : 1
stoichiometry:c48 : 1

m27*m39*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186, 11672534 These studies revealed that Syk is required for beta2 integrin-mediated spreading and extracellular signal-regulated protein kinase (ERK) activation in macrophages [8] and [19] , various integrin-mediated functional and signaling responses of neutrophils [20], as well as alphaIIb/beta3 integrin-mediated spreading and concomitant downstream signaling in platelets. PMID: 17913496, 17086186 The two ITAM-bearing adapters are also required for beta2 integrin-induced activation of ERK in macrophages with a predominant role for DAP12 in these cells.

Go back
565.0, 261.0
22.0, 22.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m6*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496 Later studies suggested that this ITAM-independent Syk activation occurs through the direct binding of Syk to integrin beta-chains.

Go back
748.0, 248.0
23.0, 23.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m13*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types. PMID: 17913496, 16943434, 17086186 The ITAM-mediated signaling model proposes that integrins activate Syk through Src-family mediated phosphorylation of the ITAM tyrosines within transmembrane adapters (DAP12 and FcR¦Ã) possibly through association with yet unidentified immunoreceptor-like molecules, followed by recruitment of Syk via its tandem SH2 domains [7] and 8[8] PY, phosphotyrosine.

Go back
936.0, 252.0
23.0, 23.0

p19

p19

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m14*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types. PMID: 17913496, 16943434, 17086186 The ITAM-mediated signaling model proposes that integrins activate Syk through Src-family mediated phosphorylation of the ITAM tyrosines within transmembrane adapters (DAP12 and FcR¦Ã) possibly through association with yet unidentified immunoreceptor-like molecules, followed by recruitment of Syk via its tandem SH2 domains [7] and 8[8] PY, phosphotyrosine.

Go back
615.0, 107.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c30 : 1
stoichiometry:c6 : 1

m2214*m23*0.1

nodelay

--

true

0

false

PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk. PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types.

Go back
831.0, 251.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m32*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496 Later studies suggested that this ITAM-independent Syk activation occurs through the direct binding of Syk to integrin beta-chains.

Go back
931.0, 375.0
25.0, 25.0

p21

p21

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c67 : 1

m6*m41628*m2891*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages. PMID: 17913496 DAP12, FcRgamma and all known DAP12- and FcRgamma-associated molecules contain a charged residue within their membrane-spanning region (Box 2). These residues probably form intramembrane salt bridges that stabilize the receptor?adapter complex.

Go back
935.0, 423.0
25.0, 25.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c36 : 1
stoichiometry:c66 : 1

m21*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.

Go back
935.0, 479.0
25.0, 25.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c41 : 1
stoichiometry:c69 : 1

m34*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.

Go back
934.0, 530.0
27.0, 27.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c32 : 1
stoichiometry:c71 : 1

m35*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.

Go back
935.0, 583.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c35 : 1
stoichiometry:c73 : 1

m36*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages.

Go back
1123.0, 639.0
25.0, 25.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c80 : 1

m35*m2529*0.1

nodelay

--

true

0

false

PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.

Go back
1132.0, 700.0
23.0, 23.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c79 : 1
stoichiometry:c81 : 1

m36*m2529*0.1

nodelay

--

true

0

false

PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.

Go back
1123.0, 875.0
25.0, 25.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.

Go back
1122.0, 930.0
27.0, 27.0

p29

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17913496, 10689303, 10781399 The phospho-ITAM then recruits the Syk or the related ZAP-70 tyrosine kinase through their dual phosphotyrosine-binding SH2 domains, leading to their phosphorylation and activation, which in turn initiates further downstream signaling.

Go back
899.0, 107.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c39 : 1
stoichiometry:c9 : 1

m2217*m26*0.1

nodelay

--

true

0

false

PMID: 17913496, 7541794, 17086186, 9351824 Similar results were later obtained using beta1 or beta2 integrin-mediated activation of human monocytic cell lines [11] or primary murine macrophages [8] and [12], and beta2 integrin-dependent activation of human neutrophils [13] as well as in CHO cells heterologously expressing the alphaIIb and beta3 integrin subunits and Syk. PMID: 17913496, 16943434, 17086186, 17353363 Unexpectedly, three recent reports using genetically modified mice indicate that beta2 and beta3 integrins, which do not share structural similarity with classical immunoreceptors, also signal by an ITAM-based, immunoreceptor-like mechanism in several different primary cell types.

Go back
877.0, 1029.0
29.0, 29.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c90 : 1
stoichiometry:c88 : 1

m27*m40*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186, 11672534 These studies revealed that Syk is required for beta2 integrin-mediated spreading and extracellular signal-regulated protein kinase (ERK) activation in macrophages [8] and [19] , various integrin-mediated functional and signaling responses of neutrophils [20], as well as alphaIIb/beta3 integrin-mediated spreading and concomitant downstream signaling in platelets. PMID: 17913496, 17086186 The two ITAM-bearing adapters are also required for beta2 integrin-induced activation of ERK in macrophages with a predominant role for DAP12 in these cells.

Go back
111.0, 491.0
25.0, 25.0

p31

p31

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m18*m41628*m2891*0.1

nodelay

--

true

0

false

PMID: 17913496 Hence, DAP12 and FcRgamma are required for osteoclast development and function, possibly as a result of their role in alphaV/beta3 integrin signal transduction.

Go back
488.0, 528.0
24.0, 24.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c122 : 1
stoichiometry:c95 : 1

m2552*m43*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
488.0, 588.0
23.0, 23.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c124 : 1
stoichiometry:c97 : 1

m2530*m39*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
492.0, 704.0
23.0, 23.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m39*m5542*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
887.0, 1223.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c173 : 1
stoichiometry:c101 : 1

m10568*m44*0.1

nodelay

--

true

0

false

PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.

Go back
490.0, 818.0
25.0, 25.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c132 : 1
stoichiometry:c103 : 1

m90*m39*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
488.0, 500.0
23.0, 23.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c121 : 1
stoichiometry:c107 : 1

m2552*m40*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
486.0, 466.0
27.0, 27.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c120 : 1
stoichiometry:c105 : 1

m2552*m39*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
494.0, 618.0
20.0, 20.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c125 : 1
stoichiometry:c110 : 1

m2530*m40*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
491.0, 283.0
25.0, 25.0

p4

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m122*m5*0.1

nodelay

--

true

0

false

PMID: 17913496 Ligand binding and receptor clustering leads to phosphorylation of these tyrosines by Src-family tyrosine kinases.

Go back
492.0, 644.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c126 : 1
stoichiometry:c112 : 1

m2530*m43*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
492.0, 736.0
23.0, 23.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c108 : 1
stoichiometry:c113 : 1

m40*m5542*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
493.0, 765.0
22.0, 22.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m43*m5542*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
493.0, 849.0
22.0, 22.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c133 : 1
stoichiometry:c117 : 1

m90*m40*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
491.0, 879.0
25.0, 25.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c134 : 1
stoichiometry:c119 : 1

m90*m43*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
489.0, 561.0
21.0, 21.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m44*m2552*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
493.0, 677.0
21.0, 21.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m44*m2530*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
492.0, 792.0
23.0, 23.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m44*m5542*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
493.0, 913.0
21.0, 21.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m44*m90*0.1

nodelay

--

true

0

false

PMID: 17913496 Activation of these kinases leads to downstream signaling, such as phosphorylation of SLP-76/SLP-65, Vav family members and PLCgamma isoforms.

Go back
747.0, 107.0
25.0, 25.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c149 : 1
stoichiometry:c145 : 1

m6*m2529*0.1

nodelay

--

true

0

false

PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.

Go back
486.0, 350.0
27.0, 27.0

p5

p5

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c25 : 1
stoichiometry:c23 : 1

m1066*m18*0.1

nodelay

--

true

0

false

PMID: 17013496, 17353363, 14624447, 15073337 Plating preosteoclasts on alphaVbeta3-integrin-ligands also leads to Syk phosphorylation.

Go back
301.0, 521.0
21.0, 21.0

p50

p50

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m20*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.

Go back
1101.0, 169.0
29.0, 29.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c148 : 1
stoichiometry:c147 : 1

m32*m2529*0.1

nodelay

--

true

0

false

PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.

Go back
296.0, 556.0
23.0, 23.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m2529*m65*0.1

nodelay

--

true

0

false

PMID: 17913496, 11719224 The beta1 and beta2 integrin chains and the Syk-related ZAP-70 can also participate in such complexes.

Go back
505.0, 253.0
25.0, 25.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m67*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496, 17353363 Beta3 integrins and Syk can also be co-precipitated from primary murine preosteoclasts following adhesion to alphaV/beta3 integrin-ligands.

Go back
296.0, 276.0
23.0, 23.0

p54

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c160 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 17913496, 17353363 However, in contrast to the case of alphaIIb/beta3, this association does not depend on the last amino acids of the beta3 integrin tail.

Go back
317.0, 249.0
21.0, 21.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c163 : 1
stoichiometry:c162 : 1

m69*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496, 17353363 However, in contrast to the case of alphaIIb/beta3, this association does not depend on the last amino acids of the beta3 integrin tail.

Go back
299.0, 315.0
25.0, 25.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c166 : 1
stoichiometry:c164 : 1

m16*m122*0.1

nodelay

--

true

0

false

PMID: 17913496, 17353363, 14593208, 15937333 The interpretation of these findings is further complicated by the binding of c-Src to the same amino acids in the beta3 cytoplasmic tail.

Go back
356.0, 828.0
23.0, 23.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c169 : 1
stoichiometry:c168 : 1

m72*m45*0.1

nodelay

--

true

0

false

PMID: 17913496, 12094222 Members of the Vav family are guanine-nucleotide exchange factors that activate Rho-family small GTPases.

Go back
884.0, 1140.0
24.0, 24.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c172 : 1
stoichiometry:c171 : 1

m74*m44*0.1

nodelay

--

true

0

false

PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.

Go back
882.0, 1082.0
27.0, 27.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c178 : 1
stoichiometry:c175 : 1

m74*m40*0.1

nodelay

--

true

0

false

PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.

Go back
159.0, 387.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m11*m19*0.1

nodelay

--

true

0

false

PMID: 17913496, 7961845 Syk, a central component of immunoreceptor signaling, was shown in 1994 to be activated through alphaIIb/beta3 integrins in human platelets.

Go back
885.0, 1177.0
27.0, 27.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c179 : 1
stoichiometry:c177 : 1

m10568*m40*0.1

nodelay

--

true

0

false

PMID: 17913496, 15249579 Later studies, however, revealed that Vav1 and Vav3 have a critical but overlapping role in neutrophil activation by beta2-integrins.

Go back
1093.0, 1061.0
27.0, 27.0

p61

p61

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e72

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 17913496 Vav1¡Ý/¡Ý animals show a severe defect in B- and T-cell development and an impaired Fcvar epsilonRI-induced activation of mast cells.

Go back
308.0, 676.0
23.0, 23.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c182 : 1

m2530*m76*0.1

nodelay

--

true

0

false

PMID: 17913491, 16493428 The SLP-76 adapter protein is phosphorylated upon T-cell receptor (TCR) ligation and participates in TCR signaling and T-cell development.

Go back
81.0, 733.0
30.0, 30.0

p63

p63

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e74

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17913491, 16493428 The SLP-76 adapter protein is phosphorylated upon T-cell receptor (TCR) ligation and participates in TCR signaling and T-cell development.

Go back
113.0, 617.0
29.0, 29.0

p64

p64

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e44

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 17913496, 16493428 The SLP-76-related SLP-65 adapter is required for B-cell development and B-cell receptor (BCR)-mediated signal transduction.

Go back
160.0, 424.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m12*m17*0.1

nodelay

--

true

0

false

PMID: 17013496, 17353363, 14624447, 15073337 Plating preosteoclasts on alphaVbeta3-integrin-ligands also leads to Syk phosphorylation.

Go back
924.0, 312.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c64 : 1
stoichiometry:c20 : 1
stoichiometry:c65 : 1

m41628*m32*m2891*0.1

nodelay

--

true

0

false

PMID: 17913496, 17086186 Integrin-mediated adhesion of neutrophils leads to phosphorylation of DAP12 and FcRgamma by Src-family kinases and their association with the Syk SH2 domains [8]. DAP12 and/or FcRgamma are also required for adhesion-induced Syk phosphorylation in neutrophils and macrophages. PMID: 17913496 DAP12, FcRgamma and all known DAP12- and FcRgamma-associated molecules contain a charged residue within their membrane-spanning region (Box 2). These residues probably form intramembrane salt bridges that stabilize the receptor?adapter complex.

Go back
491.0, 319.0
25.0, 25.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m16*m1066*0.1

nodelay

--

true

0

false

PMID: 17913496, 7961845 Syk, a central component of immunoreceptor signaling, was shown in 1994 to be activated through alphaIIb/beta3 integrins in human platelets.

Go back
297.0, 139.99360766977432

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 201.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 1199.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.0, 1236.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 831.2423130131261

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.46151659883145, 843.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 488.9711254108328

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.83284100938965, 493.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 508.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0845160176153, 522.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 738.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
447.0, 618.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.9953043210112, 199.29682226419433

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.63257703060543, 635.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.0, 624.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.67789925606615, 659.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.27750403090425, 753.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 744.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.99276672546495, 777.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 839.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.65685424949237, 871.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 848.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.1554175279993, 898.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.9527493161926, 297.86820407382015

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.0588235294117, 490.7647058823529

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
517.9048340716762, 522.0402062376344

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.7243024839461, 552.3340230853559

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.5719657765205, 583.5617174213495

c123

c123

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
518.6358398242802, 605.3861999450876

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.4978869895342, 634.7895681909881

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.3434243782576, 664.1739751733137

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.2115171315687, 696.46323846437

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.9630421157134, 717.7680887080118

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.9138789406724, 751.1706921509871

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
192.0, 400.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.8288875127964, 779.6457582787215

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.7361992804774, 809.0374544639674

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.9447769932467, 770.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
522.9860315579991, 829.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.9997520110354, 888.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.994366125047, 924.3001837082528

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 523.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.9977333899531, 571.1904222235703

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.0, 631.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.8587085313798, 679.49689686312

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
101.0, 400.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.0, 750.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.6058387158518, 787.4801647986474

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 849.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.0, 924.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.0, 140.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.6839244307548, 132.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 184.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.6568542494924, 198.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
987.0, 184.0249083549149

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.96723746472, 60.18458224376195

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
184.0, 369.8608380291771

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
326.90350490244987, 571.2387938718573

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
269.4929882637097, 579.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
258.0, 574.4090509434968

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.0, 535.7870092506352

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.20449602968955, 541.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.25864451030543, 331.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
511.0, 234.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0659023220582, 284.19165839362654

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.6564023547028, 242.43760156980184

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 337.3738459977247

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
191.0, 436.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.8094964814716, 279.73544366254924

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.0, 263.51589011760905

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.66630208618557, 242.2864409730729

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.64549371159, 265.35508511651653

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.93163436434037, 323.0436361005711

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
261.0, 297.81673490323385

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.9996389341786, 324.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 840.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 851.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.80370958807373, 793.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
99.0, 436.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.0, 1108.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 1152.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.481701988328, 967.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
909.3954710098458, 967.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
839.0, 1096.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.1845869638607, 1108.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.0, 1189.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.5357429061181, 1201.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.7854554457522, 853.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
906.8995700892395, 853.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
183.0, 442.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 1081.1284204244507

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.6929482290265, 626.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 699.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 705.5033029011098

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
119.0, 748.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
149.84242786761905, 574.0

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 206.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.0, 80.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 340.94635316997733

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 331.9808197552494

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.5093580761338, 341.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 375.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 333.8797383948072

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
256.0, 373.2165717239894

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
523.9924492668405, 333.3474977942105

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 344.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
188.0, 548.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
101.0, 548.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 132.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
628.0, 67.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.0, 410.95309653130255

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
590.0, 344.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.1256389183169, 348.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.0, 406.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 346.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 333.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
128.0, 676.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 676.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0, 120.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
194.96782774194344, 519.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
263.0, 454.5256566912205

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 338.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.8, 350.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 438.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.0, 544.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.9999820736434, 556.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.0, 1007.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 996.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.7924528301887, 1005.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 214.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.0, 138.97515460333108

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0, 219.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.0, 279.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
594.2717874351216, 195.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 291.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.490188052155, 202.1985128575696

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
954.4323213903456, 205.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.0, 204.50195718328627

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 270.42956156648484

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
863.3626473476678, 191.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 269.08323569464864

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 132.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
844.0, 235.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 388.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 397.368890451637

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.2309042531355, 342.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.5666828386379, 207.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.0, 324.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 436.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
956.0, 381.6465269501284

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.2002965935146, 396.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 492.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.15541752799933, 684.5777087639997

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.1305157602862, 450.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.0, 544.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.2795279250937, 509.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 596.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.0, 598.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1065.9999883646105, 641.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1082.0, 459.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1050.0, 513.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 654.9347299805391

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.0, 675.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.0, 140.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 652.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1064.0, 712.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.0, 675.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 888.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1049.0, 735.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 944.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 326.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 325.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
841.0, 1044.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.9999989206419, 771.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 132.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.999996042832, 833.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.7978585482262, 479.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.8763550048592, 391.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.96704968810096, 441.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 515.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.25848485227027, 545.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.0, 604.7152583587409

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
454.2680368629481, 611.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.0, 722.197769023179

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
451.9721061734058, 727.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back