1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17959357.csml convertedTime:2009.07.01.11:09

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll like receptors and autoimmunity: a critical appraisal.
Authors Papadimitraki ED, Bertsias GK, Boumpas DT.
Affiliation Department of Internal Medicine and Division of Rheumatology, Immunology andAllergy, University of Crete, Medical School, Voutes 71500, Heraklion, Greece.
Abstract There is a constant interplay between the innate and adaptive immune systems,which leads to a protective immune response against pathogens and contributeseffectively to self-non-self discrimination. Toll-like receptors (TLRs) are keycomponents of the innate immune system, which activate multiple inflammatorypathways and coordinate systemic defense against pathogens. In addition torecognizing unique molecular patterns associated with different classes ofpathogens, TLRs may also recognize a number of self proteins and endogenousnucleic acids. Data originating predominantly from animal models of autoimmunedisease and circumstantial data from human patients suggest that inappropriateactivation of TLR pathways by endogenous or exogenous ligands may lead to theinitiation and/or perpetuation of autoimmune responses and tissue injury.
PMID 17959357
Model Abstract

Entity

G010228:IFN-beta G010237:HLA-DRA G010262:IL-6 G010329:TNF-alpha G013255:TLR9 MO000000018:MEK MO000000022:p38 MO000000023:JNK MO000000058:NF-kappaB MO000000212:TRAF6 MO000000213:IRAK-1 MO000000276:AP-1 MO000000289:TNF-alpha MO000007384:IL-6 MO000007694:IRF-3 MO000007702:IRF-7 MO000008272:ROS MO000016573:MyD88 MO000016608:IKK-i MO000016659:IFNalpha1 MO000016808:TGFbeta MO000016882:LPS MO000016916:MKK7 {activated} MO000016917:MKK4 MO000016966:MKK3 MO000017426:fibrinogen MO000017549:fibronectin MO000017793:modofied low density lipoprotein MO000019005:MKK6 MO000019331:TBK1 MO000019394:TLR4 MO000019395:TLRs MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019479:protein remnants MO000020119:Hsp60 MO000021014:NO MO000021891:Hsp MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000061958:TRIAD3 e1: e10: e100:hyaluronate: TLR4 e101:modofied low density lipoprotein: TLR4 e102:fibronectin: TLR e103:peptidoglycan e104:peptidoglycan: TLR2 e105:IL8 e106:MMP e107:urate crystals e108:urate crystals: TLR4 e109:urate crystals: TLR2 e11: e110:IFN type I e111:poly I:C e112:poly I: C: TLR3 e113:imiquimod e114:imiquimod: TLR7 e115:CXCL-10 e116:CXCL-10 e12:LPS: TLR4 e13:TLR2: TLR6 e14:TLR2: TLR1 e15:Lipotechoic acid e16:Lipotechoic acid: TLR2: TLR6 e17:Triacylated lipopeptide: TLR2: TLR1 e18:Triacylated lipopeptide e19:flagellin: TLR5 e2: e20:TLR ligand e21:TLR ligand: TLR e22:CpG oligonucleotide e23:CpG oligonucleotide: TLR9 e24:zymosan e25:zymosan: TLR2: TLR6 e26:F protein of RSV e27:F protein of RSV: TLR4 e28:ssRNA e29:ssRNA: TLR7 e3: e30:ssRNA: TLR8 e31:Hsp60: TLR4 e32:fibrinogen products e33:fibrinogen products: TLR4 e34:TLR{ub} e35:TLR e36:TLR ligand: TLR: MyD88 e37:TLR ligand: TLR: MyD88: IRAK-4: IRAK-1 e38:IFN-alpha e39:TLR ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6 e4: e40:NF-kappaB {activated} e41:MKK3 [activated} e42:MKK6 {activated} e43:MKK4{activated} e44:MKK7 e45:MEK {actiavted} e46:p38 {activated} e47:JNK {activated} e48:AP-1 {activated} e49:NF-kappaB {nucleus} e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:inflammatory cytokines e64:ssRNA: TLR7: MyD88 e65:ssRNA: TLR8: MyD88 e66:CpG oligonucleotide: TLR9: MyD88 e67:IRAK-1 {activated} e68:TRAF6 {activated} e69:TBK1 {activated} e7: e70:IRF-7 {activated} e71:IRF-3 [activated} e72:TARF6: TBK1 e73:IRF-3 [activated} e74:protosoal GPI e75:protosoal GPI: TLR2 e76:LPS: TLR4: TIRAP e77:LPS: TLR4: TIRAP: MyD88 e78:zymosan: TLR2: TLR6: TIRAP e79:zymosan: TLR2: TLR6: TIRAP: MyD88 e8: e80:fibrinogen: TLR2 e81:hyaluronate e82:hyaluronate: TLR2 e83:TGF-beta e84:TBK1 {activated}: IKK-i e85:adaptor mediating TRIF pathway e86:LPS: TLR4: adaptor mediating TRIF pathway e87:LPS: TLR4: adaptor mediating TRIF pathway: TRIF e88:endogenous ssRNA e89:endogenous ssRNA: TLR7 e9: e90:endogenous ssRNA: TLR8 e91:endogenous hypomethylated DNA e92:endogenous hypomethylated DNA: TLR9 e93:pathogenic antibody e94:hydroxychloroquine e95:CpG ODN e96:CpG ODN: TLR9 e97:endogenous ssRNA: TLR3 e98:Hsp: TLR2 e99:modofied low density lipoprotein: TLR2

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
667.0, 1155.0
26.0, 26.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46 p102

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
557.0, 1169.0
30.0, 30.0

HLA-DRA

--

G010237

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p75

--

true true true true

csml-variable:Double

m93226

10

false

infinite

0

unit false false false
TRANSFACG010237

--

Go back
674.0, 1292.0
27.0, 27.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p49 p92

p51

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
713.0, 1349.0
29.0, 29.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p48

p50 p108

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
798.0, 1278.0
27.5, 27.5

TLR9

--

G013255

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p74

--

true true true true

csml-variable:Double

m95738

10

false

infinite

0

unit false false false
TRANSFACG013255

--

Go back
908.0, 648.0
31.0, 31.0

MEK

--

MO000000018

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000018

--

Go back
892.0, 728.0
24.0, 24.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
897.0, 841.0
30.0, 30.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1000.0, 940.0
32.0, 32.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p96 p97

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1018.0, 582.0
28.0, 28.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p38

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1019.0, 543.0
26.0, 26.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p35 p36 p37

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
774.0, 1096.0
27.0, 27.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
589.0, 1721.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p50 p108

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
482.0, 1358.0
28.0, 28.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
615.0, 889.0
26.0, 26.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
762.0, 862.0
27.0, 27.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
994.0, 1350.0
28.0, 28.0

ROS

--

MO000008272

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61 p62 p63 p79 p80 p81 p89

--

true true true true

csml-variable:Double

m1063

10

false

infinite

0

unit false false false
TRANSPATHMO000008272

--

Go back
861.0, 489.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p32 p33 p34 p53 p55

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
569.0, 791.0
27.0, 27.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
240.0, 1228.0
24.0, 24.0

IFNalpha1

--

MO000016659

cso30:c:Protein

cso30:i:CC_CellComponent

--

p107

--

true true true true

csml-variable:Double

m1635

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
1205.0, 1181.0
30.0, 30.0

TGFbeta

--

MO000016808

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m1746

10

false

infinite

0

unit false false false
TRANSPATHMO000016808

--

Go back
890.0, 158.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1039.0, 919.0
25.0, 25.0

MKK7 {activated}

--

MO000016916

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p27

true true true true

csml-variable:Double

m1831

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016916

--

Go back
1035.0, 811.0
25.0, 25.0

MKK4

--

MO000016917

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1832

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
1022.0, 670.0
27.0, 27.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
1203.0, 1555.0
26.0, 26.0

fibrinogen

--

MO000017426

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m2254

10

false

infinite

0

unit false false false
TRANSPATHMO000017426

--

Go back
1259.0, 1299.0
26.0, 26.0

fibronectin

--

MO000017549

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m2341

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017549

--

Go back
1310.0, 1642.0
28.0, 28.0

modofied low density lipoprotein

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p82 p84

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
1031.0, 743.0
26.0, 26.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
719.0, 703.0
25.0, 25.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42 p44 p67

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
849.0, 307.0
22.0, 22.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p9 p10 p13 p83 p84 p94

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1148.0, 332.0
32.0, 32.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p14 p85

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
349.0, 1425.0
22.0, 22.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p56 p57 p78 p82 p90 p95

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
400.0, 442.0
23.0, 23.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p77 p101

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
405.0, 1501.0
29.0, 29.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
942.0, 406.0
26.0, 26.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
627.0, 163.0
34.0, 34.0

Hsp60

--

MO000020119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m4645

10

false

infinite

0

unit false false false
InterProIPR002423
TRANSPATHMO000020119

--

Go back
1255.0, 1151.0
26.0, 26.0

NO

--

MO000021014

cso30:c:Protein

cso30:i:CC_CellComponent

--

p98 p99

--

true true true true

csml-variable:Double

m218100

10

false

infinite

0

unit false false false
TRANSPATHMO000021014

--

Go back
1280.0, 1608.0
32.0, 32.0

Hsp

--

MO000021891

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m6220

10

false

infinite

0

unit false false false
TRANSPATHMO000021891

--

Go back
268.0, 1568.0
32.0, 32.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
162.0, 438.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
836.0, 358.0
24.0, 24.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p54

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
1010.0, 474.0
28.0, 28.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
623.0, 461.0
25.0, 25.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p66

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
479.0, 411.0
26.0, 26.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

p42

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
430.0, 422.0
27.0, 27.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p41 p105 p107 p108

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
395.0, 597.0
25.0, 25.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p69

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
391.0, 725.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p70 p76

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
387.0, 481.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p68 p103

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1069.0, 357.0
29.0, 29.0

TRIAD3

--

MO000061958

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m36851

10

false

infinite

0

unit false false false
TRANSPATHMO000061958

--

Go back
325.2618353864531, 296.74228378411544
873.6431270889049, 1268.529820533089

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
333.6793260861826, 316.13117470524963
846.8277228095003, 1191.2484911039146

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1155.625, 1328.5
25.628853524412598, 31.382269621729712

hyaluronate: TLR4

--

e100

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p83

p63

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1154.5, 1441.0
27.091025876307572, 37.8014314553129

modofied low density lipoprotein: TLR4

--

e101

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p84

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1149.5, 1206.0
29.868688551908015, 36.57390434927512

fibronectin: TLR

--

e102

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p85

p88 p89

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
155.0, 1372.0
42.74179983179142, 24.220353238015136

peptidoglycan

--

e103

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p90

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
327.625, 1369.5
24.06928011998, 29.47258790201633

peptidoglycan: TLR2

--

e104

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p90

p91 p92 p93

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
627.0, 1243.0
25.0, 25.0

IL8

--

e105

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p91

--

true true true true

csml-variable:Double

m109

10

false

infinite

0

unit false false false
Affymetrix1369_s_at
EnsemblENSG00000169429
HGNCIL8
OMIM146930
ProteomeHumanPSD/IL8
RefSeqNM_000584
TRANSFACG000317
UnigeneHs.551925

--

Go back
643.5, 1217.0
41.003460207612456, 21.868512110726645

MMP

--

e106

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p93

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1250.5, 1058.25
34.83179142136249, 19.738015138772074

urate crystals

--

e107

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p94 p95

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1149.625, 990.5
29.27874520913181, 35.851524745875686

urate crystals: TLR4

--

e108

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p94

p96 p99

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
1153.625, 1102.5
28.249916680553238, 34.59173471088152

urate crystals: TLR2

--

e109

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p95

p97 p98

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
393.0, 426.7151309426735
238.39432613354043, 397.9973071890464

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
612.5, 1161.0
39.550173010380625, 21.093425605536332

IFN type I

--

e110

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p100

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
401.5, 223.25
41.54331370899916, 23.541211101766187

poly I:C

--

e111

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p101

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
530.625, 423.5
27.449716713881024, 33.611898016997166

poly I: C: TLR3

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

p101

p102

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
154.5, 502.25
35.48780487804878, 20.109756097560975

imiquimod

--

e113

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p103

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
584.625, 717.5
23.35889851691385, 28.602732877853693

imiquimod: TLR7

--

e114

cso30:c:Complex

cso30:i:CC_Cytosol

--

p103

p104

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
745.5, 1318.0
36.79930795847751, 19.62629757785467

CXCL-10

--

e115

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p105 p106

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
745.5, 1728.125
37.69470718454418, 23.245069430468906

CXCL-10

--

e116

cso30:c:Protein

cso30:i:CC_Extracellular

--

p105 p106

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
889.5, 289.0
28.211131478086983, 34.54424262622897

LPS: TLR4

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p52 p65 p106

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
350.5, 879.0
27.247625395767376, 33.36443926012331

TLR2: TLR6

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p3 p8

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
344.625, 1145.5
29.899308448591903, 36.61139810031661

TLR2: TLR1

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
103.5, 944.25
41.54331370899916, 23.541211101766187

Lipotechoic acid

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
344.875, 935.5
29.472242613323544, 41.12405946045146

Lipotechoic acid: TLR2: TLR6

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
346.875, 1189.5
27.16796659937603, 37.90879060378051

Triacylated lipopeptide: TLR2: TLR1

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
234.5, 1143.25
43.81412952060555, 24.828006728343144

Triacylated lipopeptide

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
453.625, 1490.5
29.27874520913181, 35.851524745875686

flagellin: TLR5

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
325.2618353864531, 296.74228378411544
873.6431270889049, 1268.529820533089

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1223.5, 461.375
33.506151142354994, 21.778998242530754

TLR ligand

--

e20

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1155.875, 397.5
32.25, 45.0

TLR ligand: TLR

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p17

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
101.5, 732.125
36.314031180400896, 12.709910913140313

CpG oligonucleotide

--

e22

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
394.625, 761.5
26.78832694550908, 32.80203299450091

CpG oligonucleotide: TLR9

--

e23

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p7

p34 p100

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
108.5, 993.25
38.18755256518082, 21.639613120269132

zymosan

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
344.625, 985.5
30.209590068321948, 36.99133477753708

zymosan: TLR2: TLR6

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p54

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
697.5, 148.375
29.850615114235495, 19.402899824253076

F protein of RSV

--

e26

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
697.625, 312.5
28.527537077153802, 34.93167805365772

F protein of RSV: TLR4

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
231.5, 522.625
40.93090211132437, 22.511996161228407

ssRNA

--

e28

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p11 p12

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
389.625, 519.5
29.401224795867357, 36.00149975004166

ssRNA: TLR7

--

e29

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

p32

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
342.7346979282311, 314.21514632589356
838.6974020053487, 1233.5840954495336

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
389.625, 648.5
28.298908515247458, 34.65172471254791

ssRNA: TLR8

--

e30

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p12

p33 p48 p49

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
630.625, 323.5
27.319071821363103, 33.45192467922013

Hsp60: TLR4

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p10

p62 p87

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
553.5, 169.25
36.396131202691336, 20.624474348191754

fibrinogen products

--

e32

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
557.625, 276.5
28.87047992001333, 35.351608065322445

fibrinogen products: TLR4

--

e33

cso30:c:Complex

cso30:i:CC_Extracellular

--

p13

p61 p86

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1044.5, 314.125
31.560000000000006, 23.669999999999998

TLR{ub}

--

e34

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p15

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
857.5, 1186.0
37.88927335640139, 20.207612456747405

TLR

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p16

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1151.875, 465.5
32.25, 45.0

TLR ligand: TLR: MyD88

--

e36

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p18

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1155.875, 525.5
32.25, 45.0

TLR ligand: TLR: MyD88: IRAK-4: IRAK-1

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p19

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
722.0, 1190.0
28.0, 28.0

IFN-alpha

--

e38

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p39 p104

p107

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
1143.875, 623.5
41.183015232152684, 57.46467241695724

TLR ligand: TLR: MyD88: IRAK-4: IRAK-1: TRAF6

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p20 p21 p22 p23 p24 p25

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
375.0594936305207, 344.7926557740051
774.0478106007699, 1172.4290765533094

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1000.0, 984.0
32.0, 32.0

NF-kappaB {activated}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20 p96 p97

p29

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1026.0, 706.0
27.0, 27.0

MKK3 [activated}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p26

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
1031.0, 775.0
26.0, 26.0

MKK6 {activated}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

p26

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
1035.0, 847.0
25.0, 25.0

MKK4{activated}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p27

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
1039.0, 883.0
25.0, 25.0

MKK7

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016916

--

Go back
908.0, 684.0
31.0, 31.0

MEK {actiavted}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

--

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000018

--

Go back
892.0, 768.0
24.0, 24.0

p38 {activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p28

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
901.0, 881.0
30.0, 30.0

JNK {activated}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

p28

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
838.0, 1044.0
27.0, 27.0

AP-1 {activated}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p30

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
904.0, 1130.0
32.0, 32.0

NF-kappaB {nucleus}

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p31

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
393.0, 426.7151309426735
238.39432613354043, 397.9973071890464

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
531.9021219096658, 1005.4643182214954
437.0358105373273, 396.34346318748334

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
579.1052448354851, 1014.857082106274
255.547941357022, 384.1357589825302

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
537.599050538644, 1010.754323376975
425.641953279371, 385.7634528765238

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
538.4128974856408, 1011.568170323972
424.0142593853771, 384.1357589825302

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
531.9021219096658, 1005.4643182214954
437.0358105373273, 396.34346318748334

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
531.9021219096658, 1005.4643182214954
437.0358105373273, 396.34346318748334

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
538.4128974856408, 1011.568170323972
424.0142593853771, 384.1357589825302

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
850.9301251324443, 1168.233707620872
27.303596147330783, 24.71693967021527

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
779.3115937967189, 1282.172280200436
77.31545996470405, 69.99083744173221

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
531.9021219096658, 1005.4643182214954
437.0358105373273, 396.34346318748334

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
393.0, 426.7151309426735
238.39432613354043, 397.9973071890464

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
634.9090034220667, 1181.596078249016
13.840281963048186, 6.663839463689875

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
634.4468372312732, 1161.722932044898
47.3720345563281, 85.2696622013906

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
654.3199834353918, 1217.182874940112
7.394659052695111, 7.394659052695117

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
765.5, 1136.0
36.90311418685121, 19.68166089965398

inflammatory cytokines

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30 p31

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
598.875, 522.5
25.684391631492016, 35.83868599743072

ssRNA: TLR7: MyD88

--

e64

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p32

p35

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
610.875, 571.5
26.023719948614424, 36.31216737015966

ssRNA: TLR8: MyD88

--

e65

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p33

p36

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
610.875, 663.5
26.552440814828408, 37.04991741603965

CpG oligonucleotide: TLR9: MyD88

--

e66

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p34

p37

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
751.0, 563.0
26.0, 26.0

IRAK-1 {activated}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p36 p37

p38

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
770.0, 642.0
28.0, 28.0

TRAF6 {activated}

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p44

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
667.0, 787.0
25.0, 25.0

TBK1 {activated}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42 p67

p64

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
336.7402317951751, 301.84694806328446
856.7717253193981, 1214.0234041426154

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
782.0, 908.0
27.0, 27.0

IRF-7 {activated}

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p39

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
615.0, 921.0
26.0, 26.0

IRF-3 [activated}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

p45

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
822.625, 699.5
27.71917180469922, 33.94184302616231

TARF6: TBK1

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p40

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
667.0, 1035.0
26.0, 26.0

IRF-3 [activated}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

p46

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
160.5, 1425.25
38.18755256518082, 21.639613120269132

protosoal GPI

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p47

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
329.625, 1454.5
28.739835027495417, 35.191634727545406

protosoal GPI: TLR2

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p47

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
931.875, 275.5
32.25, 45.0

LPS: TLR4: TIRAP

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p52

p53

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
983.875, 259.5
32.25, 45.0

LPS: TLR4: TIRAP: MyD88

--

e77

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p53

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
343.875, 1029.5
32.044824738484124, 44.71370893741971

zymosan: TLR2: TLR6: TIRAP

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p55

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
343.875, 1085.5
32.25, 45.0

zymosan: TLR2: TLR6: TIRAP: MyD88

--

e79

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
339.8011375041677, 323.27328802623225
821.9113251940371, 1193.415244181742

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1082.625, 1503.5
27.539535077487088, 33.721879686718886

fibrinogen: TLR2

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p78

p60 p79

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1245.5, 1585.25
37.026913372582, 20.98191757779647

hyaluronate

--

e81

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p57 p83

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1016.625, 1513.5
23.440551574737547, 28.702716213964333

hyaluronate: TLR2

--

e82

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p59 p80

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
838.0, 1238.0
28.0, 28.0

TGF-beta

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p58 p59 p60 p86 p87 p88

--

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSFACG010254

--

Go back
667.625, 838.5
25.40022496250625, 31.102316280619895

TBK1 {activated}: IKK-i

--

e84

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p64

p43

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
839.25, 433.5
15.839569691300282, 36.55285313376989

adaptor mediating TRIF pathway

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p65

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
794.875, 279.5
26.22100385391815, 36.58744723802533

LPS: TLR4: adaptor mediating TRIF pathway

--

e86

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p65

p66

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
746.875, 303.5
26.284134703615344, 36.67553679574234

LPS: TLR4: adaptor mediating TRIF pathway: TRIF

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

p67

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
231.5, 606.625
40.93090211132438, 22.511996161228407

endogenous ssRNA

--

e88

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p68 p69 p77

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
394.625, 557.5
27.719171804699215, 33.9418430261623

endogenous ssRNA: TLR7

--

e89

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p68

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
347.9635527281478, 344.69962798918004
818.1588491478963, 1177.763902297101

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
389.625, 684.5
26.869980003332778, 32.90201633061156

endogenous ssRNA: TLR8

--

e90

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
102.5, 778.125
42.327394209354125, 14.814587973273943

endogenous hypomethylated DNA

--

e91

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p70

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
427.875, 800.5
24.92682143512571, 34.78161130482657

endogenous hypomethylated DNA: TLR9

--

e92

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p70

p71 p72 p73

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
432.0, 923.5
24.76923076923077, 37.153846153846146

pathogenic antibody

--

e93

cso30:c:Protein

cso30:i:CC_Cytosol

--

p71

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
826.5, 1422.25
35.48780487804878, 20.109756097560975

hydroxychloroquine

--

e94

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p74

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
255.5, 854.125
33.953229398663694, 11.883630289532293

CpG ODN

--

e95

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p76

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
506.625, 799.5
27.27007998666889, 33.39193467755374

CpG ODN: TLR9

--

e96

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p76

p75

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
563.625, 468.5
25.588026995500748, 31.33227795367439

endogenous ssRNA: TLR3

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
920.625, 1501.5
30.846483919346774, 37.771204799200135

Hsp: TLR2

--

e98

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p56

p58 p81

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
838.625, 1507.5
26.788326945509084, 32.80203299450092

modofied low density lipoprotein: TLR2

--

e99

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p82

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
326.0, 440.0
27.0, 27.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 17959357 Anti-viral responses are mediated by TLR4 which senses F protein from RSV, TLR3 which senses double-stranded RNA (poly I:C), TLR7 and TLR8 which sense single-stranded RNA (ss RNA). PMID: 17959357 Moreover, ds-RNA released from necrotic cells and heat shock proteins expressed in the synovial tissue are able to activate TLR-3 and TLR-4, respectively.

Go back
632.0, 228.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000020119 MO000019394

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m4645*m3961*0.1

nodelay

--

true

0

false

PMID: 17959357 Products of inflamed tissue (e.g. hsp60, fibrinogen products) are sensed by TLR4. PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis. PMID: 17959357 Moreover, ds-RNA released from necrotic cells and heat shock proteins expressed in the synovial tissue are able to activate TLR-3 and TLR-4, respectively.

Go back
595.0, 1087.0
25.0, 25.0

p100

p100

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c264 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 17959357, 16670522 In the murine model of experimental colitis, TLR-9 signaling may inhibit colonic inflammation via production of type I interferons and the distinctive apical TLR-9 expression and signaling in intestinal epithelial cells is important for the maintenance of colonic homeostasis.

Go back
411.0, 327.0
25.0, 25.0

p101

p101

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e111 MO000019398

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1

m115*m3965*0.1

nodelay

--

true

0

false

PMID: 17959357, 17114417 In this context, TLR-3 stimulation of antigen-presenting cells by the ds-RNA analog poly I:C was able to suppress relapsing demyelination in a murine experimental encephalomyelitis (EAE) model by inducing endogenous IFN-beta.

Go back
635.0, 1083.0
25.0, 25.0

p102

p102

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e112

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c269 : 1

m116*0.1

nodelay

--

true

0

false

PMID: 17959357, 17114417 In this context, TLR-3 stimulation of antigen-presenting cells by the ds-RNA analog poly I:C was able to suppress relapsing demyelination in a murine experimental encephalomyelitis (EAE) model by inducing endogenous IFN-beta.

Go back
436.0, 500.0
23.0, 23.0

p103

p103

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000042126 e113

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c273 : 1

m19940*m117*0.1

nodelay

--

true

0

false

PMID: 17959357, 15611427 Although less thoroughly studied, an important role for TLR signaling has been documented in psoriasis. Local treatment with imiquimod (TLR-7 agonist) resulted in psoriasis exacerbation, which was attributed to the TLR-7 mediated IFN-alpha production by local pDCs.

Go back
712.0, 1036.0
23.0, 23.0

p104

p104

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e114

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c274 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 17959357, 15611427 Although less thoroughly studied, an important role for TLR signaling has been documented in psoriasis. Local treatment with imiquimod (TLR-7 agonist) resulted in psoriasis exacerbation, which was attributed to the TLR-7 mediated IFN-alpha production by local pDCs.

Go back
724.0, 1440.0
23.0, 23.0

p105

p105

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e115 MO000041446

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c276 : 1
stoichiometry:c280 : 1
stoichiometry:c278 : 1

m119*m19314*0.1

nodelay

--

true

0

false

PMID: 17959357, 15948188 In cultures of human microglia, ligation of TLR3 and TLR4 by double-stranded RNA and LPS, respectively, induces the secretion of the chemokine CXCL10, which is a potent chemoattractant for T cells and is implicated in playing an important role in the MS lesion.

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779.0, 1439.0
25.0, 25.0

p106

p106

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e115 e12

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c281 : 1
stoichiometry:c279 : 1

m119*m12*0.1

nodelay

--

true

0

false

PMID: 17959357, 15948188 In cultures of human microglia, ligation of TLR3 and TLR4 by double-stranded RNA and LPS, respectively, induces the secretion of the chemokine CXCL10, which is a potent chemoattractant for T cells and is implicated in playing an important role in the MS lesion.

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440.0, 1228.0
23.0, 23.0

p107

p107

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000041446 e38

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c287 : 1
stoichiometry:c286 : 1

m19314*m40*0.1

nodelay

--

true

0

false

PMID: 17959357, 16955143 Toll-like receptor 3 mediated activation of macrophages and DCs by LCMV virus, resulting in an increased IFN-alpha and TNF-alpha secretion and thus, self reactive CD8+ cell recruitment has been implicated in the pathogenesis of mouse autoimmune hepatitis.

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649.0, 1413.0
23.0, 23.0

p108

p108

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 MO000041446

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c285 : 1
stoichiometry:c282 : 1

m93309*m19314*0.1

nodelay

--

true

0

false

PMID: 17959357, 16955143 Toll-like receptor 3 mediated activation of macrophages and DCs by LCMV virus, resulting in an increased IFN-alpha and TNF-alpha secretion and thus, self reactive CD8+ cell recruitment has been implicated in the pathogenesis of mouse autoimmune hepatitis.

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331.0, 483.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e28 MO000042126

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m29*m19940*0.1

nodelay

--

true

0

false

PMID: 17959357 Anti-viral responses are mediated by TLR4 which senses F protein from RSV, TLR3 which senses double-stranded RNA (poly I:C), TLR7 and TLR8 which sense single-stranded RNA (ss RNA).

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331.0, 597.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042007 e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m19823*m29*0.1

nodelay

--

true

0

false

PMID: 17959357 Anti-viral responses are mediated by TLR4 which senses F protein from RSV, TLR3 which senses double-stranded RNA (poly I:C), TLR7 and TLR8 which sense single-stranded RNA (ss RNA).

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560.0, 224.0
23.0, 23.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m3961*m33*0.1

nodelay

--

true

0

false

PMID: 17959357 Products of inflamed tissue (e.g. hsp60, fibrinogen products) are sensed by TLR4. PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis.

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1068.0, 236.0
23.0, 23.0

p14

p14

cso30:i:ME_Ubiquitination

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000019395 MO000061958

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m3962*m36851*0.1

nodelay

--

true

0

false

PMID: 17959357, 15928677 Ubiquitination inducing molecules (such as TRIAD 3) that promote TLR degradation; anti-inflammatory molecules (TGF-beta) that directly down-regulate TLR expression; and TLR-induced apoptosis that prevents an excessive inflammatory reaction.

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997.0, 405.0
27.0, 27.0

p15

p15

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e34

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 17959357, 15928677 Ubiquitination inducing molecules (such as TRIAD 3) that promote TLR degradation; anti-inflammatory molecules (TGF-beta) that directly down-regulate TLR expression; and TLR-induced apoptosis that prevents an excessive inflammatory reaction.

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920.0, 1184.0
23.0, 23.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

MO000016808

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m1746*0.1

nodelay

--

true

0

false

PMID: 17959357, 15928677 Ubiquitination inducing molecules (such as TRIAD 3) that promote TLR degradation; anti-inflammatory molecules (TGF-beta) that directly down-regulate TLR expression; and TLR-induced apoptosis that prevents an excessive inflammatory reaction.

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1071.0, 407.0
25.0, 25.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000016573

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m22*m1572*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

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1075.0, 475.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 MO000000213 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m17258*m184*m37*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

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1079.0, 583.0
25.0, 25.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000000212

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m38*m183*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

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892.0, 220.0
24.0, 24.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17959357 TLRs are able to recognize a variety of pathogen-derived products: lipopolysaccharide (LPS) is the ligand for TLR4; bacterial lipoproteins (e.g. lipotechoic acid) are recognized by a TLR2/6 dimer; triacylated lipopeptides by a TLR2/1 dimer; CpG oligonucleotides by TLR9; flagellin by TLR5.

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1086.0, 942.0
27.0, 27.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c59 : 1
stoichiometry:c58 : 1

m17*m41*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
1084.0, 672.0
23.0, 23.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016966 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c68 : 1
stoichiometry:c61 : 1

m1875*m41*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
1088.0, 744.0
23.0, 23.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019005 e39

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c69 : 1
stoichiometry:c63 : 1

m3613*m41*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
1092.0, 812.0
23.0, 23.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016917 e39

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c70 : 1
stoichiometry:c65 : 1

m1832*m41*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
1092.0, 884.0
23.0, 23.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 e39

MO000016916

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c71 : 1
stoichiometry:c67 : 1

m46*m41*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
1014.0, 638.0
27.0, 27.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000018 e39

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m39*m41*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
943.0, 731.0
25.0, 25.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e41 e42

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c76 : 1

m48*m43*m44*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
946.0, 846.0
27.0, 27.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e43 MO000016916

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c78 : 1

m63*m45*m1831*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
775.0, 1045.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_NuclearEnvelopeLumen

--

MO000000276 e46 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c84 : 1

m219*m49*m64*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
960.0, 1052.0
23.0, 23.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e40

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines. PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

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267.0, 943.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m15*0.1

nodelay

--

true

0

false

PMID: 17959357 TLRs are able to recognize a variety of pathogen-derived products: lipopolysaccharide (LPS) is the ligand for TLR4; bacterial lipoproteins (e.g. lipotechoic acid) are recognized by a TLR2/6 dimer; triacylated lipopeptides by a TLR2/1 dimer; CpG oligonucleotides by TLR9; flagellin by TLR5.

Go back
845.0, 1099.0
21.0, 21.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines.

Go back
843.0, 1133.0
25.0, 25.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c92 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 17959357 MyD88 is the adaptor molecule, used by all but TLR-3 TLRs, which interacts with IRAK4 (IL-1 receptor associated kinase 4) and then with TRAF6 (TNF receptor-associated factor 6), resulting in activation of NF-kappaB and MAP kinases (mitogen-activated protein kinases) and transcription of inflammatory cytokines. PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

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533.0, 493.0
21.0, 21.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e29

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m1572*m30*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

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556.0, 554.0
23.0, 23.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_EndosomeMembrane

--

MO000016573 e30

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m1572*m31*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

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561.0, 619.0
21.0, 21.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e23

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m1572*m24*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

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815.0, 531.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000213 e64

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m184*m68*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

Go back
816.0, 564.0
23.0, 23.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000213 e65

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c109 : 1
stoichiometry:c106 : 1

m184*m69*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

Go back
816.0, 596.0
23.0, 23.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000213 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c110 : 1
stoichiometry:c105 : 1

m184*m70*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

Go back
819.0, 643.0
25.0, 25.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c113 : 1
stoichiometry:c112 : 1

m183*m71*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

Go back
731.0, 1075.0
25.0, 25.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e70

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c116 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

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244.0, 1196.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 e14

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19*m14*0.1

nodelay

--

true

0

false

PMID: 17959357 TLRs are able to recognize a variety of pathogen-derived products: lipopolysaccharide (LPS) is the ligand for TLR4; bacterial lipoproteins (e.g. lipotechoic acid) are recognized by a TLR2/6 dimer; triacylated lipopeptides by a TLR2/1 dimer; CpG oligonucleotides by TLR9; flagellin by TLR5.

Go back
804.0, 816.0
23.0, 23.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e72

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c115 : 1
stoichiometry:c118 : 1

m980*m76*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

Go back
479.0, 343.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 17959357 TLR-3 signals through TRIF (Toll/IL-1 receptor domain containing adaptor protein inducing IFN-beta) that activates TBK1 and IRF3 to induce IFN-beta transcription.

Go back
653.0, 743.0
22.0, 22.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 MO000041437

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c124 : 1

m3902*m19305*0.1

nodelay

--

true

0

false

PMID: 17959357 TLR-3 signals through TRIF (Toll/IL-1 receptor domain containing adaptor protein inducing IFN-beta) that activates TBK1 and IRF3 to induce IFN-beta transcription.

Go back
667.0, 889.0
25.0, 25.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e84

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c178 : 1
stoichiometry:c127 : 1

m977*m88*0.1

nodelay

--

true

0

false

PMID: 17959357 TLR-3 signals through TRIF (Toll/IL-1 receptor domain containing adaptor protein inducing IFN-beta) that activates TBK1 and IRF3 to induce IFN-beta transcription. PMID: 17959357 In the TLR4- and TLR3-mediated signaling pathways, IRF3 is activated via TBK1 and IKKepsilon/IKK-i (MyD88-independent pathway).

Go back
773.0, 705.0
21.0, 21.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e68 MO000019331

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m72*m3902*0.1

nodelay

--

true

0

false

PMID: 17959357 TRAF6 may also interact with TBK1 (TRAF-family member-associated NF-kappaB activator-binding kinase 2) to activate IRF7 (IFN regulatory factor 7) and result in IFN-alpha induction. This pathway is mediated by TLR-7, TLR-8, TLR-9.

Go back
668.0, 922.0
24.0, 24.0

p45

p45

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e71

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 17959357 TLR-3 signals through TRIF (Toll/IL-1 receptor domain containing adaptor protein inducing IFN-beta) that activates TBK1 and IRF3 to induce IFN-beta transcription.

Go back
668.0, 1084.0
23.0, 23.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e73

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 17959357 TLR-3 signals through TRIF (Toll/IL-1 receptor domain containing adaptor protein inducing IFN-beta) that activates TBK1 and IRF3 to induce IFN-beta transcription.

Go back
244.0, 1424.0
23.0, 23.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m3964*m78*0.1

nodelay

--

true

0

false

PMID: 17959357 Protozoal glycosyl-phosphatidyl-inositol (GPI-)anchor proteins are recognized by TLR2.

Go back
644.0, 1332.0
23.0, 23.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c139 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17959357 Patients with X-linked agammaglobulinemia exhibit an impaired TLR-8-mediated IL-6 and TNF-alpha production, which may account for their increased susceptibility to enteroviral infections.

Go back
616.0, 1294.0
23.0, 23.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c138 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 17959357 Patients with X-linked agammaglobulinemia exhibit an impaired TLR-8-mediated IL-6 and TNF-alpha production, which may account for their increased susceptibility to enteroviral infections.

Go back
456.0, 1572.0
24.0, 24.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17959357 TLRs are able to recognize a variety of pathogen-derived products: lipopolysaccharide (LPS) is the ligand for TLR4; bacterial lipoproteins (e.g. lipotechoic acid) are recognized by a TLR2/6 dimer; triacylated lipopeptides by a TLR2/1 dimer; CpG oligonucleotides by TLR9; flagellin by TLR5.

Go back
590.0, 1386.0
27.0, 27.0

p50

p50

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c141 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 17959357 Patients with X-linked agammaglobulinemia exhibit an impaired TLR-8-mediated IL-6 and TNF-alpha production, which may account for their increased susceptibility to enteroviral infections.

Go back
535.0, 1359.0
25.0, 25.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c140 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 17959357 Patients with X-linked agammaglobulinemia exhibit an impaired TLR-8-mediated IL-6 and TNF-alpha production, which may account for their increased susceptibility to enteroviral infections.

Go back
890.0, 358.0
25.0, 25.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e12 MO000022528

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m12*m6810*0.1

nodelay

--

true

0

false

PMID: 17959357 TIR domain-containing adaptor protein (TIRAP)/MyD88-adaptor-like specifically mediates the MyD88-dependent pathway of TLR2 and TLR4.

Go back
935.0, 359.0
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e76 MO000016573

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m80*m1572*0.1

nodelay

--

true

0

false

PMID: 17959357 TIR domain-containing adaptor protein (TIRAP)/MyD88-adaptor-like specifically mediates the MyD88-dependent pathway of TLR2 and TLR4.

Go back
272.0, 1040.0
23.0, 23.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e25

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m6810*m26*0.1

nodelay

--

true

0

false

PMID: 17959357 TIR domain-containing adaptor protein (TIRAP)/MyD88-adaptor-like specifically mediates the MyD88-dependent pathway of TLR2 and TLR4.

Go back
399.0, 1095.0
25.0, 25.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m1572*m82*0.1

nodelay

--

true

0

false

PMID: 17959357 TIR domain-containing adaptor protein (TIRAP)/MyD88-adaptor-like specifically mediates the MyD88-dependent pathway of TLR2 and TLR4.

Go back
924.0, 1612.0
23.0, 23.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000021891

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c163 : 1
stoichiometry:c166 : 1

m3964*m6220*0.1

nodelay

--

true

0

false

PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis.

Go back
1015.0, 1583.0
25.0, 25.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e81

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c162 : 1
stoichiometry:c165 : 1

m3964*m85*0.1

nodelay

--

true

0

false

PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis.

Go back
835.0, 1327.0
25.0, 25.0

p58

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e98

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c169 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
860.0, 1312.0
23.0, 23.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c168 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
1228.0, 408.0
23.0, 23.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e20 MO000019395

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m21*m3962*0.1

nodelay

--

true

0

false

PMID: 17959357 TLRs are able to recognize a variety of pathogen-derived products.

Go back
880.0, 1292.0
23.0, 23.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e80

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c167 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
1094.0, 1402.0
27.0, 27.0

p61

p61

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e33

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c173 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
1095.0, 1367.0
25.0, 25.0

p62

p62

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e31

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c174 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
1099.0, 1331.0
25.0, 25.0

p63

p63

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e100

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c175 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
616.0, 842.0
23.0, 23.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000016608

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m73*m1599*0.1

nodelay

--

true

0

false

PMID: 17959357 In the TLR4- and TLR3-mediated signaling pathways, IRF3 is activated via TKB1 and IKKepsilon/IKK-i (MyD88-independent pathway).

Go back
836.0, 394.0
23.0, 23.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e12 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c179 : 1

m12*m89*0.1

nodelay

--

true

0

false

PMID: 17959357 In the TLR4- and TLR3-mediated signaling pathways, IRF3 is activated via TKB1 and IKKepsilon/IKK-i (MyD88-independent pathway).

Go back
749.0, 463.0
21.0, 21.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m18998*m90*0.1

nodelay

--

true

0

false

PMID: 17959357 In the TLR4- and TLR3-mediated signaling pathways, IRF3 is activated via TKB1 and IKKepsilon/IKK-i (MyD88-independent pathway).

Go back
676.0, 706.0
23.0, 23.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e87

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c187 : 1
stoichiometry:c186 : 1

m3902*m91*0.1

nodelay

--

true

0

false

PMID: 17959357 In the TLR4- and TLR3-mediated signaling pathways, IRF3 is activated via TBK1 and IKKepsilon/IKK-i (MyD88-independent pathway).

Go back
332.0, 546.0
23.0, 23.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042126 e88

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1
stoichiometry:c192 : 1

m19940*m92*0.1

nodelay

--

true

0

false

PMID: 17959357 Importantly, TLR-3, TLR-7 and TLR-8 recognize endogenous single stranded RNA.

Go back
332.0, 666.0
23.0, 23.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042007 e88

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m19823*m92*0.1

nodelay

--

true

0

false

PMID: 17959357 Importantly, TLR-3, TLR-7 and TLR-8 recognize endogenous single stranded RNA.

Go back
328.0, 726.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19828*m23*0.1

nodelay

--

true

0

false

PMID: 17959357 TLRs are able to recognize a variety of pathogen-derived products: lipopolysaccharide (LPS) is the ligand for TLR4; bacterial lipoproteins (e.g. lipotechoic acid) are recognized by a TLR2/6 dimer; triacylated lipopeptides by a TLR2/1 dimer; CpG oligonucleotides by TLR9; flagellin by TLR5.

Go back
341.0, 775.0
21.0, 21.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m19828*m95*0.1

nodelay

--

true

0

false

PMID: 17959357, 16492804 Finally, TLR-9 can be stimulated by endogenous hypomethylated DNA; the activation of TLR-9/MyD88 pathway is a prerequisite for switching to pathogenic autoantibody production in a murine model of SLE.

Go back
432.0, 870.0
23.0, 23.0

p71

p71

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 17959357 The protective effect of TLR-9 may appear at first glance to be paradoxical since it has been well established that the recognition of endogenous nucleic acids by TLR-9 within the endosomal compartment induces B cell proliferation, plasmablast differentiation and, ultimately, production of pathogenic autoantibodies.

Go back
110.0, 804.0
27.0, 27.0

p72

p72

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e92

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 17959357 The protective effect of TLR-9 may appear at first glance to be paradoxical since it has been well established that the recognition of endogenous nucleic acids by TLR-9 within the endosomal compartment induces B cell proliferation, plasmablast differentiation and, ultimately, production of pathogenic autoantibodies.

Go back
110.0, 840.0
28.0, 28.0

p73

p73

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e92

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 17959357 The protective effect of TLR-9 may appear at first glance to be paradoxical since it has been well established that the recognition of endogenous nucleic acids by TLR-9 within the endosomal compartment induces B cell proliferation, plasmablast differentiation and, ultimately, production of pathogenic autoantibodies.

Go back
800.0, 1348.0
23.0, 23.0

p74

p74

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e94

G013255

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17959357 Hydroxychloroquine, an established treatment for various aspects of lupus and an inhibitor of TLR-9 expression, also inhibited the lupus serum-mediated induction of TLR-9 on plasma cells.

Go back
560.0, 1120.0
23.0, 23.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e96

G010237

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m100*0.1

nodelay

--

true

0

false

PMID: 17959357, 17075805 An enhanced induction of HLA-DR was documented on TLR-9 stimulated (by means of its ligand ODN 2006) B-cells in active but not inactive SLE patients.

Go back
352.0, 848.0
23.0, 23.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e95

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c204 : 1

m19828*m99*0.1

nodelay

--

true

0

false

PMID: 17959357, 17075805 An enhanced induction of HLA-DR was documented on TLR-9 stimulated (by means of its ligand ODN 2006) B-cells in active but not inactive SLE patients.

Go back
280.0, 472.0
23.0, 23.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e88 MO000019398

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m92*m3965*0.1

nodelay

--

true

0

false

PMID: 17959357 Importantly, TLR-3, TLR-7 and TLR-8 recognize endogenous single stranded RNA.

Go back
1083.0, 1555.0
25.0, 25.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000017426

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c164 : 1

m3964*m2254*0.1

nodelay

--

true

0

false

PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis.

Go back
1079.0, 1443.0
25.0, 25.0

p79

p79

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e80

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c170 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
268.0, 992.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m13*m25*0.1

nodelay

--

true

0

false

PMID: 17959357 A TLR2/6 dimer recognizes zymosan for anti-fungal responses.

Go back
1039.0, 1443.0
25.0, 25.0

p80

p80

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e82

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c171 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
996.0, 1440.0
23.0, 23.0

p81

p81

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e98

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c172 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
839.0, 1643.0
25.0, 25.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000017793

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c215 : 1
stoichiometry:c214 : 1

m3964*m2549*0.1

nodelay

--

true

0

false

PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis.

Go back
1251.0, 1331.0
25.0, 25.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e81 MO000019394

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c223 : 1
stoichiometry:c222 : 1

m85*m3961*0.1

nodelay

--

true

0

false

PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis.

Go back
1312.0, 1448.0
23.0, 23.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017793 MO000019394

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m2549*m3961*0.1

nodelay

--

true

0

false

PMID: 17959357, 15690042 More specifically, TLR-2 and TLR-4 can be fibrinogen, hyalouronate, heat shock proteins and modified low density lipoprotein, implying a role for their activation in the production of proinflammatory cytokines in the synovial fluid of rheumatoid arthritis patients' or the sterile inflammation of atherosclerosis.

Go back
1259.0, 1211.0
25.0, 25.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019395 MO000017549

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m3962*m2341*0.1

nodelay

--

true

0

false

--

Go back
905.0, 1269.0
22.0, 22.0

p86

p86

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c233 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
921.0, 1245.0
21.0, 21.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c232 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
924.0, 1212.0
23.0, 23.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e102

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c231 : 1

m106*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
1100.0, 1292.0
26.0, 26.0

p89

p89

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e102

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c237 : 1

m106*0.1

nodelay

--

true

0

false

PMID: 17959357 The matrix turn-over products generated during the acute tissue injury, provide resident or immune renal cells with abundant endogenous TLR ligands (fibrinogen, hyalouran, fibronectin, HSPs) that may induce the production of reactive oxygen species and of TGF-beta, resulting in collagen production and irreversible renal fibrosis.

Go back
699.0, 221.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m3961*m27*0.1

nodelay

--

true

0

false

PMID: 17959357 Anti-viral responses are mediated by TLR4 which senses F protein from RSV, TLR3 which senses double-stranded RNA (poly I:C), TLR7 and TLR8 which sense single-stranded RNA (ss RNA).

Go back
268.0, 1372.0
23.0, 23.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c240 : 1
stoichiometry:c241 : 1

m3964*m107*0.1

nodelay

--

true

0

false

--

Go back
572.0, 1244.0
23.0, 23.0

p91

p91

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c242 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17959357, 12632416 TLR-2 activation of synovial fibroblasts through bacterial peptidoglycans results in upregulation of integrins, matrix metalloproteinases, and inflammatory cytokines (IL-6, IL-8).

Go back
588.0, 1272.0
23.0, 23.0

p92

p92

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c243 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17959357, 12632416 TLR-2 activation of synovial fibroblasts through bacterial peptidoglycans results in upregulation of integrins, matrix metalloproteinases, and inflammatory cytokines (IL-6, IL-8).

Go back
563.0, 1215.0
25.0, 25.0

p93

p93

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e104

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c244 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 17959357, 12632416 TLR-2 activation of synovial fibroblasts through bacterial peptidoglycans results in upregulation of integrins, matrix metalloproteinases, and inflammatory cytokines (IL-6, IL-8).

Go back
1255.0, 995.0
25.0, 25.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e107

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c250 : 1
stoichiometry:c252 : 1

m3961*m111*0.1

nodelay

--

true

0

false

PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

Go back
1255.0, 1107.0
25.0, 25.0

p95

p95

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e107

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c251 : 1
stoichiometry:c253 : 1

m3964*m111*0.1

nodelay

--

true

0

false

PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

Go back
1087.0, 995.0
25.0, 25.0

p96

p96

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e108 MO000000058

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c256 : 1
stoichiometry:c257 : 1

m112*m17*0.1

nodelay

--

true

0

false

PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

Go back
1087.0, 1035.0
25.0, 25.0

p97

p97

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e109 MO000000058

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c258 : 1
stoichiometry:c259 : 1

m113*m17*0.1

nodelay

--

true

0

false

PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

Go back
1083.0, 1167.0
25.0, 25.0

p98

p98

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e109

MO000021014

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c260 : 1

m113*0.1

nodelay

--

true

0

false

PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

Go back
1084.0, 1124.0
23.0, 23.0

p99

p99

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e108

MO000021014

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c261 : 1

m112*0.1

nodelay

--

true

0

false

PMID: 17959357, 15814732 Recognition of the urate crystals by TLR-2 and TLR-4 results in release of nitric oxide by chondrocytes, activation of the NF-kappaB transcription factor and thus, expression of several pro-inflammatory cytokines.

Go back
190.0, 452.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.0, 1168.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
421.0, 645.3517178529796

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 640.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.9875451412826, 545.4462315721387

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.9602975216799, 557.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.7509022872978, 559.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.1919189506982, 586.5037553862376

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
785.0, 576.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.1554175279994, 551.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.0, 540.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
637.0, 577.5351117364178

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
274.3677380085485, 1170.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
637.0, 614.7305712611322

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.6650308939505, 600.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 656.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.0, 589.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
784.0, 670.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.4227359831741, 733.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
737.5321520841902, 1100.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 845.1676940130167

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.6994371546483, 839.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.3986127739231, 935.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
267.0, 1208.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 374.8262546692157

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.20093468805436, 371.0545434011871

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 368.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.9556524591421, 723.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.0, 765.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 437.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
641.0, 902.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.8132665336364, 910.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.5601767747798, 812.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 716.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.0, 1530.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
794.0, 716.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.0, 934.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 946.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
680.0, 1061.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 1107.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.0, 1436.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.0, 1436.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.0, 1440.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
639.0, 1306.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 1347.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
300.0, 1584.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.0, 1372.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 1413.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.2543346847117, 1313.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.68, 1368.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
195.63593585741899, 667.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
172.10745566230105, 665.8647543541055

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
903.2351924128152, 324.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 370.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
911.0, 327.79428260231236

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.2104534567059, 321.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 1534.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.0, 389.0606493387102

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
954.0, 311.8262546692157

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.24924008562914, 369.69229399172195

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.79922153369904, 1014.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
295.0, 1052.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.99999991677674, 505.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.0, 1069.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
384.0, 1108.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 1447.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
361.0, 1447.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1240.0, 439.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.0, 1447.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 1568.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.0, 1596.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.0, 1624.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 1545.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1028.0, 1550.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.0, 1547.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.8776860867976, 1272.340991912837

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.1756560418075, 1273.6984752248577

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.0, 1273.9957035442658

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1180.0, 363.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1026.3768447422535, 1383.9236425126521

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1018.4437801990532, 1385.2208294496277

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.0, 1386.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1029.0750780227759, 1374.734068956465

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1029.8940545478517, 1367.2976528023867

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1029.8523918966475, 1346.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 818.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
639.0, 854.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
680.0, 870.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.7879058041051, 323.49850526621384

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1196.0, 420.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.8936172657221, 324.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.0, 425.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 474.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
765.1004955415568, 316.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0, 348.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.9900187110228, 717.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.8231932086841, 729.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.4405427526796, 340.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
359.2570816034594, 507.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
270.0, 570.4127335286158

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0, 738.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.52380597346, 622.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
269.0, 629.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
355.0, 561.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.8551517954508, 750.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
145.0, 786.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.0, 790.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.0, 835.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
444.0, 893.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
145.0, 818.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
145.94870217100774, 819.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
361.0, 454.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.0, 738.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.6444310124273, 1374.6463470275562

c200

c200

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
812.0, 1314.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.5063133166267, 751.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 860.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.0, 822.1592038910419

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.0, 833.0

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 1143.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
255.0, 502.6550446131422

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
310.7658265556951, 457.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 484.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 744.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.0, 1468.45854600288

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1033.0, 1475.6058387158519

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1093.4437601569803, 1475.9876828256433

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.45750860278554, 1447.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.0, 1548.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 1656.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.8622351286998, 1341.3528473579363

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
857.5007737731867, 1359.193370766822

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
907.502800398324, 1320.8068225197783

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
648.0, 123.6682901109163

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
293.9005733234865, 912.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 79.69102437683671

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1264.0, 1364.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1189.0, 1344.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.7419852431885, 140.14921270037422

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.0, 1344.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1324.0, 1479.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.0, 155.9091616878793

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1190.0, 1460.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1180.0, 323.51767349441604

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1272.0, 1244.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.0, 1004.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 1224.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.6024722224167, 1228.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.9947159835715, 1253.2907169448572

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.3335677176674, 1261.1966833641113

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.0, 1224.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.0, 112.09257513912559

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.0, 99.72339910578057

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1028.9678277419434, 1312.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.2771337008357, 1243.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
297.691689036638, 1395.384210058487

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.0, 1004.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
198.0, 1384.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.0, 1384.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
595.0, 1256.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.0, 1287.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 1228.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 1291.8781898919726

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.0, 1265.7312732965925

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.0, 1241.401001791228

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
871.0, 318.0

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.52064196841843, 1119.6719230308622

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.9561956340111, 244.9511191201183

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1268.0, 1028.0

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1268.0, 1078.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.0, 1008.0

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1190.0, 1120.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1120.0, 1008.0

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1116.5268621723706, 1065.783925529225

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1032.0, 966.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.9671456517417, 1002.7242859683402

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1031.0, 972.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.914786701675, 1013.0231486264291

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 168.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1108.0, 1165.758472741024

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1107.0, 1138.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1105.7497264551948, 1026.0

c262

c262

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1114.1676940130167, 1132.0

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 1112.0

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 776.102156239539

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
422.0, 247.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.0, 359.95106987738893

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 339.94244811147104

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.0, 1108.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.0, 246.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.0, 440.0

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.0, 499.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
190.0, 512.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.0, 523.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.0, 1059.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 733.0

c275

c275

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.7597385535421, 1338.0

c276

c276

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 1338.0

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
737.0, 1463.0

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.7840854374906, 1464.0

c279

c279

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 504.01438503361544

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
144.19722839818724, 400.32790646527565

c280

c280

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
791.657969783289, 195.76092077575822

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
608.4359433487315, 1436.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.9391449403893, 1378.0

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
83.8358715978384, 367.5002109117155

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
67.6447289522614, 343.54625286725104

c285

c285

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
272.0, 1240.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.93584367200884, 1206.0

c287

c287

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
363.9958409147176, 495.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.0, 439.4310835055999

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 504.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.0, 610.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 545.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 621.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 197.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.5251193663806, 246.71524925591055

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 251.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.6921915811266, 241.19776902317903

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 190.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 247.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 186.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.1787623231642, 265.09757499340304

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.9734342450795, 259.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1080.2447832916628, 266.9962541943164

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1021.7865248044973, 338.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.0, 419.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
903.0, 1196.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.0, 1196.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1104.0, 420.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.0, 428.0065968622151

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 430.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.0, 251.1326309447406

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.0, 488.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 506.20449602968955

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1108.0, 488.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 496.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1110.8715757936684, 558.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1046.0, 596.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1104.0, 605.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.0, 956.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.047955434391, 963.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1120.9997855266427, 681.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
904.0, 244.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1049.0, 684.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1059.722373185794, 692.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1057.0, 756.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.9183115728806, 763.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1060.0, 824.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.7839864320406, 832.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1064.0, 896.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.509867769654, 904.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1114.2694147517066, 662.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1111.2108369169305, 681.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
298.51732310666307, 906.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.65050174807, 681.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1108.9132624852066, 681.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
939.0, 654.8485198511377

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.2494651199621, 658.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1049.0, 652.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.0, 741.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.5424513544061, 753.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 857.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.0455126623185, 871.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
975.6770283510817, 724.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
145.0, 956.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.1326309447406, 753.6229236544714

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.0, 860.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
979.2839333778203, 874.9509778128281

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.0, 1078.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.0, 1058.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0914130007413, 792.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
802.9632245814687, 911.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
984.5631664759627, 1016.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
934.2950039375453, 1075.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.0, 1146.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
292.0, 956.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.0, 1071.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.1219853038187, 1115.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0, 1146.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 504.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.8414205652714, 507.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.386963222337, 510.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 508.8437310710337

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
554.0, 509.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.0, 577.159575575166

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.0, 571.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back