1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17967410.csml convertedTime:2009.07.01.11:09

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Intracellular NOD-like receptors in host defense and disease.
Authors Kanneganti TD, Lamkanfi M, Nunez G.
Affiliation Department of Pathology and Comprehensive Cancer Center, University of MichiganMedical School, Ann Arbor, MI 48109, USA.
Abstract The innate immune system comprises several classes of pattern recognitionreceptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), andRIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and inendosomes, whereas NLRs and RLRs detect microbial components in the cytosol.Here we discuss the recent understanding in NLRs. Two NLRs, NOD1 and NOD2, sensethe cytosolic presence of the peptidoglycan fragments meso-DAP and muramyldipeptide, respectively, and drive the activation of mitogen-activated proteinkinase (MAPK) and the transcription factor NF-kappaB. A different set of NLRsinduces caspase-1 activation through the assembly of large protein complexesnamed inflammasomes. Genetic variations in several NLR members are associatedwith the development of inflammatory disorders. Further understanding of NLRsshould provide new insights into the mechanisms of host defense and thepathogenesis of inflammatory diseases.
PMID 17967410
Model Abstract

Entity

G010389:IL-1beta G023188:DEFB1 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000039:Bcl-2 MO000000212:TRAF6 MO000000213:IRAK-1 MO000007330:proIL-18 MO000016573:MyD88 MO000016574:TAK1 MO000016597:IL-1beta MO000016599:IKK-gamma MO000016625:IL-18 MO000016632:p50:RelA-p65 MO000016828:Caspase-1{activated} MO000016882:LPS MO000017151:Bcl-xL MO000017601:Caspase-5 MO000017949:RICK MO000019395:TLRs MO000019399:TLR5 MO000019449:proIL-1beta MO000019479:protein remnants MO000020434:Nod1 MO000020461:Nod2 MO000022185:flagellin MO000038724:p50:RelA-p65:IkappaB-alpha MO000044014:ASC MO000044055:IPAF MO000044196:CARD9 MO000061612:CARDINAL MO000061796:DEFB1 MO000063086:P2RX7 MO000064988:PANX1{activated} e1: e10: e11:MDP: Nod2 e12:MDP e13:iE-DAP: Nod1{oligomer} e14:MDP: Nod2{oligomer} e15:iE-DAP: Nod1{oligomer}: RICK e16:MDP: Nod2{oligomer}: RICK e17:iE-DAP: Nod1{oligomer}: RICK: IKK-gamma e18:MDP: Nod2{oligomer}: RICK: IKK-gamma e19:iE-DAP: Nod1{oligomer}: RICK: IKK-gamma{ubK63} e2: e20:MDP: Nod2{oligomer}: RICK: IKK-gamma{ubK63} e21:CARD9{activated} e22:MDP: Nod2{oligomer}: RICK: CARD9 e23:TAK1 {activated} e24:p38 {activated} e25:ERK{activated} e26:JNK{activated} e28:proinflammatory genes e29:TLR ligand e3: e30:TLR ligand: TLR e31:MyD88{activated} e32:IRAK-1{activated} e33:TRAF6{activated} e34:flagellin: TLR5 e35:flagellin: IPAF e36:Caspase-1 e37:flagellin: IPAF: ASC e38:flagellin{cytosolic} e39:NALP1b e4: e40:NALP1 e41:MDP: NALP1 e42:MDP: NALP1: ASC e43:MDP: NALP1: ASC: CARDINAL e44:Caspase-5{activated} e45:Bcl-2: NALP1 e46:Bcl-xL: NALP1 e47:Anthrax LT e48:Anthrax LT: NALP1b e49:flagellin: IPAF: ASC: Caspase-1 e5:iE-DAP e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:iE-DAP: Nod1 e60: e61: e62: e63:MDP: NALP1: ASC: CARDINAL: Caspase-5 e64:MDP: NALP1: ASC: CARDINAL: Caspase-1 e65:NALP3 e66:LPS: NALP3 e67:peptidoglycan e68:peptidoglycan: NALP3 e69:lipoteic acid: ATP e7: e70:lipoteic acid: ATP: NALP3 e71:LPS{extracellular} e72:LPS: NALP3: ASC e73:LPS: NALP3: ASC: Caspase-1 e74:ATP e75:PANX1 e76:Pore Formng Toxins e77:bacterial ligand e78:bacterial ligand {extracellular} e79:R848 e8: e80:Francisella: unknown NLR: ASC e81:R837 e82:potasium e83:P2RX7{openned} e84:potasium{extracellular} e85:CPPD e86:MSU e87:p50:RelA-p65{nucleus} e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p7 p8 p9
Model Detail
742.0, 1165.0
28.0, 28.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p28

p52

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
670.0, 965.0
28.0, 28.0

DEFB1

--

G023188

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m101900

10

false

infinite

0

unit false false false
TRANSFACG023188

--

Go back
753.0, 776.0
30.0, 30.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
690.0, 661.0
27.0, 27.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
893.0, 762.0
28.0, 28.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
375.0, 738.0
26.0, 26.0

Bcl-2

--

MO000000039

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR004725
TRANSPATHMO000000039

--

Go back
271.0, 524.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
269.0, 429.0
28.0, 28.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
226.0, 1309.0
28.0, 28.0

proIL-18

--

MO000007330

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m841

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000007330

--

Go back
267.0, 331.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
732.0, 539.0
32.0, 32.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13 p26

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
78.0, 1333.0
28.0, 28.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
672.0, 403.0
32.0, 32.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
221.0, 1372.0
30.0, 30.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

p61

--

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
505.0, 645.0
30.0, 30.0

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p24 p36

p18

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
279.0, 1214.0
26.0, 26.0

Caspase-1{activated}

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p41 p53 p57 p60 p62 p63 p65 p67

p37 p61

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
627.0, 1402.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54

p49 p53

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
369.0, 780.0
30.0, 30.0

Bcl-xL

--

MO000017151

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m2028

10

false

infinite

0

unit false false false
InterProIPR004725
TRANSPATHMO000017151

--

Go back
575.0, 888.0
28.0, 28.0

Caspase-5

--

MO000017601

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m2380

10

false

infinite

0

unit false false false
TRANSPATHMO000017601

--

Go back
674.0, 337.0
27.0, 27.0

RICK

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
165.0, 281.0
28.0, 28.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
170.0, 637.0
28.0, 28.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
499.0, 1333.0
30.0, 30.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p37

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
562.0, 597.0
28.0, 28.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p24 p36

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
356.0, 283.0
32.0, 32.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
616.0, 291.0
32.0, 32.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
17.0, 596.0
30.0, 30.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
583.0, 527.0
33.0, 33.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p24 p36

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
361.0, 1028.0
30.0, 30.0

ASC

--

MO000044014

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p39 p55

true true true true

csml-variable:Double

m21736

10

false

infinite

0

unit false false false
InterProIPR004020
TRANSPATHMO000044014

--

Go back
309.0, 970.0
30.0, 30.0

IPAF

--

MO000044055

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m21777

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044055

--

Go back
866.0, 341.0
28.0, 28.0

CARD9

--

MO000044196

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p25

true true true true

csml-variable:Double

m21914

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044196

--

Go back
513.0, 836.0
30.0, 30.0

CARDINAL

--

MO000061612

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m36509

10

false

infinite

0

unit false false false
TRANSPATHMO000061612

--

Go back
622.0, 773.0
27.0, 27.0

DEFB1

--

MO000061796

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m36689

10

false

infinite

0

unit false false false
TRANSPATHMO000061796

--

Go back
420.0, 1495.0
32.0, 32.0

P2RX7

--

MO000063086

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p66

true true true true

csml-variable:Double

m37969

10

false

infinite

0

unit false false false
TRANSPATHMO000063086

--

Go back
561.0, 1488.0
30.0, 30.0

PANX1{activated}

--

MO000064988

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58

p54

true true true true

csml-variable:Double

m39857

10

false

infinite

0

unit false false false
TRANSPATHMO000064988

--

Go back
148.60709219598579, 88.07750999721958
987.733339626952, 1455.403138111854

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
245.74284993825967, 103.09465456099167
818.4844448287837, 1168.4084901424246

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
672.625, 272.5
31.00979003499417, 37.97117147142143

MDP: Nod2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
611.5, 175.25
41.26576955424726, 23.38393608074012

MDP

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p2 p38

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
555.875, 264.5
32.25, 45.0

iE-DAP: Nod1{oligomer}

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p6 p27

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
796.875, 270.5
29.606395668930077, 41.311249770600114

MDP: Nod2{oligomer}

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p5

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
556.5, 397.0
31.41548908056524, 43.835566158928245

iE-DAP: Nod1{oligomer}: RICK

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7 p12

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
799.5, 393.0
31.344466874655904, 43.736465406496606

MDP: Nod2{oligomer}: RICK

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p8 p11

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
555.5, 456.0
33.11213066617728, 46.20297302257295

iE-DAP: Nod1{oligomer}: RICK: IKK-gamma

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
799.5, 465.0
32.09414571481006, 44.782528904386126

MDP: Nod2{oligomer}: RICK: IKK-gamma

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p10

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
443.875, 468.5
32.25, 45.0

iE-DAP: Nod1{oligomer}: RICK: IKK-gamma{ubK63}

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p17

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
148.60709219598579, 88.07750999721958
987.733339626952, 1455.403138111854

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
799.875, 516.5
32.25, 45.0

MDP: Nod2{oligomer}: RICK: IKK-gamma{ubK63}

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
906.0, 617.0
28.0, 28.0

CARD9{activated}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p26

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044196

--

Go back
863.875, 452.5
32.25, 45.0

MDP: Nod2{oligomer}: RICK: CARD9

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p13

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
729.0, 575.0
32.0, 32.0

TAK1 {activated}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p13 p26

p14 p15 p16

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
718.0, 717.0
27.0, 27.0

p38 {activated}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p31

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
805.0, 833.0
30.0, 30.0

ERK{activated}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p32

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
897.0, 808.0
28.0, 28.0

JNK{activated}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p33

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
835.5, 1022.0
33.99653979238755, 18.13148788927336

proinflammatory genes

--

e28

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19 p31 p32 p33

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
76.5, 226.375
37.9701230228471, 24.680579964850615

TLR ligand

--

e29

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
168.36175898852477, 108.12438517782363
948.224006041874, 1415.309387750647

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
163.625, 328.5
31.00979003499417, 37.97117147142143

TLR ligand: TLR

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
267.0, 375.0
32.0, 32.0

MyD88{activated}

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p22

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
270.0, 481.0
28.0, 28.0

IRAK-1{activated}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

p23

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
271.0, 568.0
26.0, 26.0

TRAF6{activated}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p24 p25

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
173.5, 594.0
28.398933511081484, 34.77420429928346

flagellin: TLR5

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p36

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
248.625, 1021.5
32.87964505915681, 40.260789868355275

flagellin: IPAF

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p34

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
371.0, 1074.0
26.0, 26.0

Caspase-1

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p47 p53 p56 p60 p62 p63 p65 p67

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
250.875, 1066.5
27.64144797210497, 38.56946228665811

flagellin: IPAF: ASC

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34 p35

p46

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
247.0, 916.0
30.0, 30.0

flagellin{cytosolic}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
236.5, 875.125
34.410344133628506, 21.219712215737577

NALP1b

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
204.9078925547221, 143.20641674388057
875.1317389094797, 1345.1453246185315

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
245.5, 683.125
37.69470718454418, 23.245069430468906

NALP1

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38 p43

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
373.625, 677.5
29.050116647225458, 35.57157140476587

MDP: NALP1

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
431.875, 728.5
32.25, 45.0

MDP: NALP1: ASC

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
431.875, 880.5
32.25, 45.0

MDP: NALP1: ASC: CARDINAL

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40 p41 p42

p47 p48

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
522.0, 1081.0
28.0, 28.0

Caspase-5{activated}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

--

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000017601

--

Go back
246.625, 734.5
26.159598400266624, 32.03216130644893

Bcl-2: NALP1

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p41

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
244.625, 776.5
30.029953341109817, 36.77137143809365

Bcl-xL: NALP1

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
235.0, 831.0
41.32884777123634, 23.419680403700585

Anthrax LT

--

e47

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p45

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
370.5, 826.0
27.990668221963002, 34.27428761873021

Anthrax LT: NALP1b

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
250.5, 1120.0
30.34226463571298, 42.33804367773904

flagellin: IPAF: ASC: Caspase-1

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p35

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
412.0, 213.0
47.88898233809923, 27.13708999158957

iE-DAP

--

e5

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
612.6548470930566, 876.6781111908543
369.99881699167395, 340.5116605660371

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
652.617475371487, 884.7477425201787
216.34940136943328, 330.0236217395678

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
617.4779229197636, 881.2229280156577
360.35266533826, 331.42202691643024

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
618.1669337521503, 881.9221306040889
358.97464367348636, 330.0236217395678

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
612.6548470930566, 876.6781111908543
369.99881699167395, 340.5116605660371

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
612.6548470930566, 876.6781111908543
369.99881699167395, 340.5116605660371

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
618.1669337521503, 881.9221306040889
358.97464367348636, 330.0236217395678

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
882.7470933886545, 1016.518628877112
23.115493125632497, 21.23513304225816

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
822.1141401386224, 1114.406991257492
65.45602907673931, 60.13142260509077

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
612.6548470930566, 876.6781111908543
369.99881699167395, 340.5116605660371

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
423.5, 266.0
33.690051658056994, 41.253124479253465

iE-DAP: Nod1

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
699.861486417947, 1027.9986794753868
11.71731887797249, 5.725122910512502

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
699.4702119737844, 1010.9250081696616
40.10563052666153, 73.25796176526295

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
716.2950130727745, 1058.5724629763372
6.260391106600816, 6.35299397422334

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
516.875, 943.5
32.25, 45.0

MDP: NALP1: ASC: CARDINAL: Caspase-5

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p42

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
431.875, 1012.5
32.25, 45.0

MDP: NALP1: ASC: CARDINAL: Caspase-1

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
748.5, 1343.125
39.59046085731536, 24.414117528677803

NALP3

--

e65

cso30:c:Protein

cso30:i:CC_Cell

--

--

p49 p50 p51 p65 p67

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
624.625, 1335.5
31.099608398600232, 38.08115314114314

LPS: NALP3

--

e66

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p49

p55

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
821.5, 1310.25
45.0, 25.5

peptidoglycan

--

e67

cso30:c:SmallMolecule

cso30:i:CC_Cell

--

--

p50

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
831.625, 1267.5
25.71867188801866, 31.492251291451424

peptidoglycan: NALP3

--

e68

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p50

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
817.5, 1406.25
45.0, 25.5

lipoteic acid: ATP

--

e69

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p51

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
208.70130729908652, 292.0843017183832
828.0956221136829, 1190.746736071294

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
885.625, 1337.5
28.870479920013334, 35.351608065322445

lipoteic acid: ATP: NALP3

--

e70

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p51

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
627.0, 1574.0
26.0, 26.0

LPS{extracellular}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
624.875, 1238.5
29.472242613323544, 41.12405946045146

LPS: NALP3: ASC

--

e72

cso30:c:Complex

cso30:i:CC_Cell

--

p55 p57

p56

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
531.875, 1124.5
32.25, 45.0

LPS: NALP3: ASC: Caspase-1

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
463.5, 1378.625
33.17658349328215, 18.247120921305182

ATP

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Cell

--

--

p37 p57 p62 p63 p66 p58

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
485.0, 1493.0
28.0, 28.0

PANX1

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
TRANSPATHMO000064988

--

Go back
1068.125, 1480.5
20.147464278526865, 32.67156369490843

Pore Formng Toxins

--

e76

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p59

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
995.5, 1545.375
37.33743409490334, 24.26933216168717

bacterial ligand

--

e77

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p59

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
995.5, 1404.375
37.33743409490334, 24.26933216168717

bacterial ligand {extracellular}

--

e78

cso30:c:Protein

cso30:i:CC_Extracellular

--

p59

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
341.5, 1595.25
45.0, 25.5

R848

--

e79

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p62

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
272.6597646599134, 302.0998309822959
794.4019976909337, 1170.5336997112777

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
482.625, 1238.5
27.139435094150976, 33.2319613397767

Francisella: unknown NLR: ASC

--

e80

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p60

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
381.5, 1567.25
45.0, 25.5

R837

--

e81

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p63

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
249.875, 1420.5
27.935637621804826, 28.409123005225258

potasium

--

e82

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p64

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
316.0, 1491.0
32.0, 32.0

P2RX7{openned}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p66

p64 p58

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
TRANSPATHMO000063086

--

Go back
249.875, 1588.5
27.935637621804826, 28.409123005225258

potasium{extracellular}

--

e84

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

p64

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
75.5, 1215.25
41.54331370899916, 23.541211101766187

CPPD

--

e85

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p65

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
85.5, 1278.25
45.0, 25.5

MSU

--

e86

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p67

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
741.0, 921.0
30.0, 30.0

p50:RelA-p65{nucleus}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p19 p28

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
171.54898428878502, 120.11536024620861
790.7751168146567, 1155.1824435487704

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
361.0, 214.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000020434

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m4923*0.1

nodelay

--

true

0

false

PMID: 17967410, 12796777, 1279199716870615 NOD1 recognizes the dipeptide gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), which is produced by most Gram-negative and specific Gram-positive bacteria.

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729.0, 472.0
30.0, 30.0

p10

p10

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e18

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 17967410, 15620648, 17348859 This CARD-containing serine-threonine kinase directly binds and promotes K63-type polyubiquitylation of the regulator IKK-gamma and activation of the kinase TAK1 a prerequisite for activation of the IKK complex.

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867.0, 402.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044196 e16

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m21914*m16*0.1

nodelay

--

true

0

false

PMID: 17967410 The NLR proteins NOD1 and NOD2 sense intracellular iE-DAP and MDP, respectively, leading to recruitment of the adaptor proteins RICK and CARD9. PMID: 17967410, 17187069 The CARD-containing adaptor protein CARD9 was found to be important for the activation of p38 and JNK downstream of NOD2, although it was dispensable for NF-kappaB activation

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663.0, 577.0
27.0, 27.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e15

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c34 : 1
stoichiometry:c33 : 1

m1573*m15*0.1

nodelay

--

true

0

false

PMID: 17967410, 15620648, 17348859 This CARD-containing serine-threonine kinase directly binds and promotes K63-type polyubiquitylation of the regulator IKK-gamma and activation of the kinase TAK1 a prerequisite for activation of the IKK complex.

Go back
806.0, 576.0
27.0, 27.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c35 : 1
stoichiometry:c31 : 1

m1573*m22*0.1

nodelay

--

true

0

false

PMID: 17967410, 15620648, 17348859 This CARD-containing serine-threonine kinase directly binds and promotes K63-type polyubiquitylation of the regulator IKK-gamma and activation of the kinase TAK1 a prerequisite for activation of the IKK complex. PMID: 17967410, 17187069 The CARD-containing adaptor protein CARD9 was found to be important for the activation of p38 and JNK downstream of NOD2, although it was dispensable for NF-kappaB activation

Go back
739.0, 662.0
26.0, 26.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c38 : 1
stoichiometry:c37 : 1

m24*m23*0.1

nodelay

--

true

0

false

PMID: 17967410, 11463746, 15692051, 14560001 In addition to the NF-kappaB pathway, NOD1 or NOD2 stimulation results in the activation of the MAP kinases p38, ERK, and JNK. PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
807.0, 778.0
25.0, 25.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011 e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c41 : 1
stoichiometry:c40 : 1

m26*m23*0.1

nodelay

--

true

0

false

PMID: 17967410, 11463746, 15692051, 14560001 In addition to the NF-kappaB pathway, NOD1 or NOD2 stimulation results in the activation of the MAP kinases p38, ERK, and JNK. PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
843.0, 763.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e23

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1
stoichiometry:c43 : 1

m28*m23*0.1

nodelay

--

true

0

false

PMID: 17967410, 11463746, 15692051, 14560001 In addition to the NF-kappaB pathway, NOD1 or NOD2 stimulation results in the activation of the MAP kinases p38, ERK, and JNK. PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
506.0, 529.0
27.0, 27.0

p17

p17

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e19 MO000038724

MO000019479 MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c202 : 1
stoichiometry:c47 : 1
stoichiometry:c205 : 1

m19*m16910*0.1

nodelay

--

true

0

false

PMID: 17967410 These events result in the degradation of the NF-kappaB inhibitor IkappaB-alpha and the subsequent translocation of NF-kappaB to the nucleus, where transcription of NF-¦ÊB-dependent target genes occurs.

Go back
638.0, 841.0
27.0, 27.0

p18

p18

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016632

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 17967410 These events result in the degradation of the NF-kappaB inhibitor IkappaB-alpha and the subsequent translocation of NF-kappaB to the nucleus, where transcription of NF-¦ÊB-dependent target genes occurs. PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
785.0, 978.0
24.0, 24.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e87

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c52 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17967410 These events result in the degradation of the NF-kappaB inhibitor IkappaB-alpha and the subsequent translocation of NF-kappaB to the nucleus, where transcription of NF-¦ÊB-dependent target genes occurs. PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
618.0, 217.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e12 MO000020461

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m12*m4947*0.1

nodelay

--

true

0

false

PMID: 17967410, 12527755, 12514169 In contrast, NOD2 is activated by muramyl dipeptide (MDP), a component of virtually all types of PGN.

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81.0, 281.0
27.0, 27.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e29 MO000019395

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m33*m3962*0.1

nodelay

--

true

0

false

PMID: 17967410 Extracellular PAMPs are recognized by TLRs, which signals through MyD88, IRAK proteins, and TRAF members.

Go back
217.0, 377.0
27.0, 27.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016573 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c58 : 1
stoichiometry:c57 : 1

m1572*m34*0.1

nodelay

--

true

0

false

PMID: 17967410 Extracellular PAMPs are recognized by TLRs, which signals through MyD88, IRAK proteins, and TRAF members.

Go back
217.0, 429.0
27.0, 27.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000213 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c61 : 1
stoichiometry:c60 : 1

m184*m35*0.1

nodelay

--

true

0

false

PMID: 17967410 Extracellular PAMPs are recognized by TLRs, which signals through MyD88, IRAK proteins, and TRAF members.

Go back
222.0, 524.0
25.0, 25.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c64 : 1
stoichiometry:c63 : 1

m183*m36*0.1

nodelay

--

true

0

false

PMID: 17967410 Extracellular PAMPs are recognized by TLRs, which signals through MyD88, IRAK proteins, and TRAF members.

Go back
439.0, 566.0
25.0, 25.0

p24

p24

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e33 MO000038724

MO000019479 MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c203 : 1
stoichiometry:c66 : 1
stoichiometry:c206 : 1

m37*m16910*0.1

nodelay

--

true

0

false

PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
908.0, 467.0
23.0, 23.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000044196 e33

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m21914*m37*0.1

nodelay

--

true

0

false

PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
806.0, 617.0
27.0, 27.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e21

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m1573*m21*0.1

nodelay

--

true

0

false

PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
671.0, 826.0
25.0, 25.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G023188 e13

MO000061796

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c75 : 1

m101900*m13*0.1

nodelay

--

true

0

false

PMID: 17967410, 16513653 Moreover, H. pylori-induced production of beta-defensins was abolished in Nod1¡Ý/¡Ý mice.

Go back
743.0, 982.0
25.0, 25.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e87

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c78 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17967410 Recognition of PAMPs by TLRs induces synthesis of the IL-1beta precursor through activation of NF-kappaB.

Go back
75.0, 598.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 17967410 These results demonstrate that TLR5 and Ipaf represent two flagellin receptors that have evolved to control distinct signaling pathways (NF-kappaB activation and caspase-1 activation, respectively) when the host is infected with Salmonella or Legionella.

Go back
731.0, 278.0
25.5, 25.5

p3

p3

cso30:i:ME_Polymerization

cso30:i:CC_Cytosol

--

e11

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 17967410 The current model proposes that when PAMPs are sensed by the C-terminal LRRs, the molecule undergoes conformational rearrangements triggering oligomerization via the NOD domain.

Go back
248.0, 973.0
27.0, 27.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000044055 e38

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c104 : 1
stoichiometry:c85 : 1

m21777*m42*0.1

nodelay

--

true

0

false

PMID: 17967410, 16984919, 16648852, 16648853 Flagellin was identified as the bacterial molecule that is sensed by Ipaf, and flagellin-deficient bacteria are compromised in their capability to induce caspase-1 activation and secretion of IL-1beta. PMID: 17967410, 16984919, 16648852, 16648853 The finding that recombinant purified flagellin induces Ipaf-dependent caspase-1 activation when delivered directly into the cytosol indicates that the cytosolic presence of flagellin is essential and sufficient for Ipaf activation.

Go back
806.0, 951.0
25.0, 25.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c89 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
843.0, 948.0
23.0, 23.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e25

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c90 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
878.0, 967.0
25.0, 25.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c91 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 17967410 The subsequent activation of NF-kappaB and MAP kinases results in the transcriptional upregulation of proinflammatory genes.

Go back
314.0, 1031.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000044014

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m39*m21736*0.1

nodelay

--

true

0

false

PMID: 17967410 The inflammasome adaptor ASC is required for recruitment of caspase-1, although its role in the Nalp1b inflammasome needs to be confirmed.

Go back
314.0, 1129.0
27.0, 27.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49

MO000016828 e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 17967410 Ipaf rapidly activates caspase-1 when it senses the intracellular pathogens Salmonella typhimurium or Legionella pneumophila. PMID: 17967410, 16984919, 16648852, 16648853 Flagellin was identified as the bacterial molecule that is sensed by Ipaf, and flagellin-deficient bacteria are compromised in their capability to induce caspase-1 activation and secretion of IL-1beta.

Go back
443.0, 598.0
25.0, 25.0

p36

p36

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e34 MO000038724

MO000019479 MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c204 : 1
stoichiometry:c100 : 1
stoichiometry:c207 : 1

m38*m16910*0.1

nodelay

--

true

0

false

PMID: 17967410 These results demonstrate that TLR5 and Ipaf represent two flagellin receptors that have evolved to control distinct signaling pathways (NF-kappaB activation and caspase-1 activation, respectively) when the host is infected with Salmonella or Legionella.

Go back
298.0, 1333.0
27.0, 27.0

p37

p37

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000019449 MO000016828 e74

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c185 : 1
stoichiometry:c102 : 1

m4012*m1765*m79*0.1

nodelay

--

true

0

false

PMID: 17967410, 16984919, 16648852, 16648853 Flagellin was identified as the bacterial molecule that is sensed by Ipaf, and flagellin-deficient bacteria are compromised in their capability to induce caspase-1 activation and secretion of IL-1beta. PMID: 17967410 Active caspase-1 processes the IL-1beta precursor into the mature cytokine, which is secreted through an unknown mechanism. PMID: 17967410, 15190255, 12191486 This bipartite CARD-PYD protein bridges the association of caspase-1 to the NLR proteins Nalp1 and Cryopyrin in the inflammasomes and therefore plays a major role in the activation of caspase-1 and the subsequent maturation of the inflammatory cytokines IL-1beta and IL-18. PMID: 17967410, 16407888 Bacterial RNA and the imidazoquinoline compounds R837 and R848 alone induce IL-1beta secretion, but a brief pulse with ATP markedly enhances caspase-1 activation and IL-1beta maturation.

Go back
307.0, 682.0
26.0, 26.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m12*m44*0.1

nodelay

--

true

0

false

PMID: 17967410, 17349957 Although there is no evidence for a physical interaction between cryopyrin and microbial molecules, purified NALP1 has been shown to mediate caspase-1 activation in response to MDP.

Go back
436.0, 683.0
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044014 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m21736*m45*0.1

nodelay

--

true

0

false

PMID: 17967410, 15030775, 17349957 In contrast to mouse Nalp1b, human NALP1 interacts with ASC and the adaptor protein CARDINAL to recruit and activate the inflammatory caspase-1 and -5.

Go back
483.0, 274.0
25.0, 25.0

p4

p4

cso30:i:ME_Polymerization

cso30:i:CC_Cytosol

--

e6

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 17967410 The current model proposes that when PAMPs are sensed by the C-terminal LRRs, the molecule undergoes conformational rearrangements triggering oligomerization via the NOD domain.

Go back
436.0, 807.0
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000061612

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m46*m36509*0.1

nodelay

--

true

0

false

PMID: 17967410, 15030775, 17349957 In contrast to mouse Nalp1b, human NALP1 interacts with ASC and the adaptor protein CARDINAL to recruit and activate the inflammatory caspase-1 and -5.

Go back
327.0, 1162.0
25.0, 25.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 e46 e64

MO000016828 e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c136 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 17967410, 15030775, 17349957 In contrast to mouse Nalp1b, human NALP1 interacts with ASC and the adaptor protein CARDINAL to recruit and activate the inflammatory caspase-1 and -5. PMID: 17967410, 17418785 Recently, Reed and colleagues showed that the antiapoptotic Bcl-2 members Bcl-2 and Bcl-XL specifically interact with human Nalp1 and prevent Nalp1-mediated caspase-1 activation.

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520.0, 1021.0
25.0, 25.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63

e44 e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c118 : 1
stoichiometry:c138 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17967410, 15030775, 17349957 In contrast to mouse Nalp1b, human NALP1 interacts with ASC and the adaptor protein CARDINAL to recruit and activate the inflammatory caspase-1 and -5.

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308.0, 739.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000000039

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m44*m49*0.1

nodelay

--

true

0

false

PMID: 17967410, 17418785 Recently, Reed and colleagues showed that the antiapoptotic Bcl-2 members Bcl-2 and Bcl-XL specifically interact with human Nalp1 and prevent Nalp1-mediated caspase-1 activation.

Go back
303.0, 782.0
25.0, 25.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017151

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m2028*0.1

nodelay

--

true

0

false

PMID: 17967410, 17418785 Recently, Reed and colleagues showed that the antiapoptotic Bcl-2 members Bcl-2 and Bcl-XL specifically interact with human Nalp1 and prevent Nalp1-mediated caspase-1 activation.

Go back
303.0, 830.0
25.0, 25.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 e39

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c129 : 1
stoichiometry:c128 : 1

m65*m43*0.1

nodelay

--

true

0

false

PMID: 17967410 Salmonella and Legionella flagellin are sensed by Ipaf, whereas mouse Nalp1b recognizes anthrax lethal toxin.

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315.0, 1074.0
25.0, 25.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 e36

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m41*m40*0.1

nodelay

--

true

0

false

PMID: 17967410, 12191486 The prodomain of the prototypical inflammatory caspase-1 encodes a CARD, also present in the C terminus of NOD1, NOD2, and RICK. Caspase-1 is recruited to large multiprotein complexes known as ¡Èinflammasomes¡É through homotypic interactions with the CARD motif in the adaptor ASC.

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436.0, 963.0
23.0, 23.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 e36

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m47*m40*0.1

nodelay

--

true

0

false

PMID: 17967410, 15030775, 17349957 In contrast to mouse Nalp1b, human NALP1 interacts with ASC and the adaptor protein CARDINAL to recruit and activate the inflammatory caspase-1 and -5.

Go back
520.0, 889.0
25.0, 25.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017601 e43

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c119 : 1

m2380*m47*0.1

nodelay

--

true

0

false

PMID: 17967410, 15030775, 17349957 In contrast to mouse Nalp1b, human NALP1 interacts with ASC and the adaptor protein CARDINAL to recruit and activate the inflammatory caspase-1 and -5.

Go back
680.0, 1343.0
23.0, 23.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e65 MO000016882

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m70*m155666*0.1

nodelay

--

true

0

false

PMID: 17967410, 17008311, 17433728, 16407890 Cryopyrin and the inflammasome adaptor ASC are required for caspase-1 activation in response to microbial products with diverse molecular structures such as LPS, peptidoglycan, and lipoteichoic acid when combined with millimolar concentrations of ATP.

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799.0, 338.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017949 e14

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c16 : 1

m2684*m14*0.1

nodelay

--

true

0

false

PMID: 17967410, 10329646, 11087742 Direct or indirect ligand recognition by the LRRs of NOD1 and NOD2 induces the recruitment of RICK through homotypic CARD interactions.

Go back
755.0, 1270.0
25.0, 25.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cell_WithoutCellWall_

--

e65 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m70*m72*0.1

nodelay

--

true

0

false

PMID: 17967410, 17008311, 17433728, 16407890 Cryopyrin and the inflammasome adaptor ASC are required for caspase-1 activation in response to microbial products with diverse molecular structures such as LPS, peptidoglycan, and lipoteichoic acid when combined with millimolar concentrations of ATP.

Go back
828.0, 1343.0
23.0, 23.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cell

--

e65 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m70*m74*0.1

nodelay

--

true

0

false

PMID: 17967410, 17008311, 17433728, 16407890 Cryopyrin and the inflammasome adaptor ASC are required for caspase-1 activation in response to microbial products with diverse molecular structures such as LPS, peptidoglycan, and lipoteichoic acid when combined with millimolar concentrations of ATP.

Go back
611.0, 1166.0
25.0, 25.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389

MO000019449

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m93364*0.1

nodelay

--

true

0

false

PMID: 17967410, 17433728 Nevertheless, TLRs are still essential for NF-kappaB-dependent production of pro-IL-1beta.

Go back
404.0, 1259.0
23.0, 23.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000016882

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m40*m155666*0.1

nodelay

--

true

0

false

PMID: 17967410, 17433728, 15507117 Indeed, the TLR4 ligand LPS induced activation of caspase-1 in macrophages deficient in MyD88, TRIF, or TLR4.

Go back
626.0, 1489.0
27.0, 27.0

p54

p54

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e71 MO000064988

MO000016882

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m76*m39857*0.1

nodelay

--

true

0

false

PMID: 17967410 In this model, pannexin-1 delivers bacterial molecules into the cytosol where they are sensed by cryopyrin. PMID: 17967410, 17036048 Notably, pannexin-1 was found to be critical for caspase-1 activation and IL-1beta secretion in LPS-stimulated macrophages pulsed with ATP.

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520.0, 1247.0
23.0, 23.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044014 e66

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m21736*m71*0.1

nodelay

--

true

0

false

PMID: 17067410 Another NLR protein, the CIITA transcription factor, is required for the transcription of genes encoding MHC II, whereas the NLR family members Nalp1 and Cryopyrin recruit the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) to activate caspase-1.

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535.0, 1198.0
26.0, 26.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 e36

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m77*m40*0.1

nodelay

--

true

0

false

PMID: 17067410 Another NLR protein, the CIITA transcription factor, is required for the transcription of genes encoding MHC II, whereas the NLR family members Nalp1 and Cryopyrin recruit the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) to activate caspase-1.

Go back
454.0, 1185.0
27.0, 27.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e73 e74

MO000016828 e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c186 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m78*m79*0.1

nodelay

--

true

0

false

PMID: 17967410 Cryopyrin/Nalp3 mediates caspase-1 activation in response to a wide variety of microbial components and the endogenous danger signal uric acid. PMID: 17967410 The latter is more consistent with the fact that cryopyrin induces caspase-1 activation in response to a plethora of bacterial ligands in the presence of ATP.

Go back
561.0, 1424.0
30.0, 30.0

p58

p58

cso30:i:ME_ChannelOpening_ClosingInThePlasmaMembrane

cso30:i:CC_Cell_WithoutCellWall_

--

e74 e83 e75

MO000064988

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c193 : 1

m79*m88*m80*0.1

nodelay

--

true

0

false

PMID: 17967410 Bacteria and bacterial products enter the cytosol via pore-forming toxins, type III or IV secretion systems, or ATP-mediated activation of the pannexin-1 pore. PMID: 17967410, 17240370, 17121814, 17036048 Recent studies have revealed that the rapid activation of P2X7 receptor is followed by the gradual opening of a larger pore attributed to the hemichannel pannexin-1, which is recruited upon P2X7 receptor activation.

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999.0, 1481.0
30.0, 30.0

p59

p59

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e77 e76

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c170 : 1
stoichiometry:c169 : 1

m82*m81*0.1

nodelay

--

true

0

false

PMID: 17967410 Bacteria and bacterial products enter the cytosol via pore-forming toxins, type III or IV secretion systems, or ATP-mediated activation of the pannexin-1 pore.

Go back
559.0, 338.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000017949

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c15 : 1

m13*m2684*0.1

nodelay

--

true

0

false

PMID: 17967410, 10329646, 11087742 Direct or indirect ligand recognition by the LRRs of NOD1 and NOD2 induces the recruitment of RICK through homotypic CARD interactions.

Go back
340.0, 1215.0
23.0, 23.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e36 e80

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1

m40*m85*0.1

nodelay

--

true

0

false

PMID: 17967410 Francisella induce ASC-dependent caspase-1 activation through an NLR, the identity of which is unknown.

Go back
274.0, 1373.0
27.0, 27.0

p61

p61

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cell

--

MO000007330 MO000016828

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c176 : 1
stoichiometry:c175 : 1

m841*m1765*0.1

nodelay

--

true

0

false

PMID: 17967410, 15190255, 12191486 This bipartite CARD-PYD protein bridges the association of caspase-1 to the NLR proteins Nalp1 and Cryopyrin in the inflammasomes and therefore plays a major role in the activation of caspase-1 and the subsequent maturation of the inflammatory cytokines IL-1beta and IL-18.

Go back
352.0, 1303.0
23.0, 23.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e36 e79 e74

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c181 : 1
stoichiometry:c184 : 1
stoichiometry:c180 : 1

m40*m84*m79*0.1

nodelay

--

true

0

false

PMID: 17967410, 16407888 Bacterial RNA and the imidazoquinoline compounds R837 and R848 alone induce IL-1beta secretion, but a brief pulse with ATP markedly enhances caspase-1 activation and IL-1beta maturation.

Go back
393.0, 1300.0
22.0, 22.0

p63

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell

--

e36 e81 e74

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c178 : 1

m40*m86*m79*0.1

nodelay

--

true

0

false

PMID: 17967410, 16407888 Bacterial RNA and the imidazoquinoline compounds R837 and R848 alone induce IL-1beta secretion, but a brief pulse with ATP markedly enhances caspase-1 activation and IL-1beta maturation.

Go back
248.0, 1491.0
32.0, 32.0

p64

p64

cso30:i:ME_IonTransportThroughIonChannel

cso30:i:CC_Extracellular

--

e82 e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c192 : 1
stoichiometry:c191 : 1

m87*m88*0.1

nodelay

--

true

0

false

PMID: 17967410, 17491021 Stimulation of the P2X7 receptor with ATP induces K+ efflux, a signal that has been implicated in cryopyrin-mediated caspase-1 activation.

Go back
221.0, 1180.0
27.0, 27.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e36 e65 e85

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c195 : 1

m40*m70*m90*0.1

nodelay

--

true

0

false

PMID: 17967410, 16407889 The finding that monosodium urate (MSU) and calcium pyrophosphate dehydrate (CPPD) crystals require cryopyrin, but not ATP, to activate caspase-1 suggests a role for the cryopyrin inflammasome in the pathogenesis of gout and pseudogout.

Go back
420.0, 1427.0
34.0, 34.0

p66

p66

cso30:i:ME_ChannelOpening_ClosingInThePlasmaMembrane

cso30:i:CC_Extracellular

--

MO000063086 e74

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c189 : 1
stoichiometry:c188 : 1

m37969*m79*0.1

nodelay

--

true

0

false

PMID: 17967410, 17121814 ATP triggers the potassium-selective channel of the purinergic P2X7 receptor to open.

Go back
222.0, 1237.0
27.0, 27.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e36 e65 e86

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c198 : 1
stoichiometry:c201 : 1
stoichiometry:c197 : 1

m40*m70*m91*0.1

nodelay

--

true

0

false

PMID: 17967410, 16407889 The finding that monosodium urate (MSU) and calcium pyrophosphate dehydrate (CPPD) crystals require cryopyrin, but not ATP, to activate caspase-1 suggests a role for the cryopyrin inflammasome in the pathogenesis of gout and pseudogout.

Go back
615.0, 406.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000016599

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m15*m1593*0.1

nodelay

--

true

0

false

PMID: 17967410, 15620648, 17348859 This CARD-containing serine-threonine kinase directly binds and promotes K63-type polyubiquitylation of the regulator IKK-gamma and activation of the kinase TAK1 a prerequisite for activation of the IKK complex.

Go back
737.0, 404.0
27.0, 27.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016599 e16

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m1593*m16*0.1

nodelay

--

true

0

false

PMID: 17967410, 15620648, 17348859 This CARD-containing serine-threonine kinase directly binds and promotes K63-type polyubiquitylation of the regulator IKK-gamma and activation of the kinase TAK1 a prerequisite for activation of the IKK complex.

Go back
501.0, 464.0
30.0, 30.0

p9

p9

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e17

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 17967410, 15620648, 17348859 This CARD-containing serine-threonine kinase directly binds and promotes K63-type polyubiquitylation of the regulator IKK-gamma and activation of the kinase TAK1 a prerequisite for activation of the IKK complex.

Go back
392.0, 226.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 291.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 611.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.9998678854236, 1347.045976252215

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
114.0, 1347.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
294.0, 1240.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
262.0, 946.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.5952087680341, 187.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.0, 695.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.0, 695.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
379.0, 713.8322478382808

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
403.0, 695.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 310.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 706.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.0, 774.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.4087388781564, 826.0183750985082

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 830.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
359.9999439536526, 1058.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.43526425198644, 1187.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.0, 902.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 902.1428343713351

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 1046.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
533.0, 914.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 351.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 706.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 751.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 751.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 795.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.0, 795.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
123.54966363070452, 750.7702728241304

c125

c125

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
139.5489083943139, 794.5515348698837

c126

c126

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
276.0, 843.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.0, 843.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.0, 856.5743412935054

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 351.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 1087.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
286.99870284292075, 1098.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.0, 1141.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 926.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
391.0, 992.9216145650802

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 986.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 933.927964395254

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
533.0, 989.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
467.3722931859362, 932.6994814945797

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
711.0, 1355.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 312.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0, 1372.0621504188273

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 1355.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.0, 1303.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0866522822413, 1292.7120559573646

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 1283.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 1355.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 1374.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 1355.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.3499304188223, 1191.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.0, 1179.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
572.0, 363.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 1100.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.5425150864371, 1234.6665457376293

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.7228671074463, 1282.3362492843028

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 1524.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
640.0, 1436.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 1503.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
387.0, 1058.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.0115218004042, 1274.2784093857208

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.0, 1259.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.110425339268, 1221.66631306556

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.0, 363.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.0, 1097.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 1178.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
487.7165612572172, 1157.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.89819759330015, 1201.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.0, 1204.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.0, 1397.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 1445.169105221059

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
513.0, 1457.337986572682

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 1519.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 1437.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 419.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.9973714472758, 1496.2050608063405

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.7641695155406, 1100.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 1227.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.8569840954163, 1230.5059219516215

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.0, 1337.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
259.0, 1387.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.240492763455, 1240.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 1100.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
311.4, 1241.8

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.7065873224072, 1100.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 419.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.03358582934374, 1246.2179589656598

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
364.0, 1334.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.0, 1330.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.6065740582214, 1327.706691452118

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
381.7585526044338, 1326.2804166494748

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.7709054007669, 1351.900797004504

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
469.47818538223225, 1219.985695883279

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.0, 1468.9965420357148

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
354.86834615253457, 1454.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.86745234925706, 1397.0

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
594.4585460028801, 431.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 1449.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 1523.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.0, 1507.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 1454.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.48126283187764, 1096.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
248.0, 1201.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.34451205202885, 1100.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 1235.1808595010743

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
55.60121063099626, 1251.0035628920655

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
32.04731357858503, 1194.0313646026602

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
372.0, 244.99811031059133

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
704.0, 418.24231301312614

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
117.0, 1198.8698122592389

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
131.0, 1257.4290863355068

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.99840047984, 543.1599680095968

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.7873373466686, 548.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.26552309679255, 552.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 556.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 591.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 620.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.9969153652218, 416.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 431.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 479.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.8446454055274, 482.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.0, 487.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.0, 498.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 369.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.0, 415.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.0, 427.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.0, 236.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 563.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.9980254226529, 590.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.1554175279994, 563.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 591.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
585.0, 441.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
830.7222292166489, 498.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
717.0, 675.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.6079254665552, 688.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 607.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.0, 791.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.0, 199.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 803.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.0, 607.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
876.0, 776.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 786.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.0, 607.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.0, 675.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.0, 865.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0, 556.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.0, 505.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
756.0, 951.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0, 252.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 999.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
95.0, 251.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
108.0, 303.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
116.0, 295.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.16769401301673, 361.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 391.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
195.0, 360.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
252.0, 443.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0, 244.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.0, 456.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.65685424949237, 407.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
255.0, 537.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 548.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
253.03684417730804, 507.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.0, 951.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
464.0, 582.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.0, 579.1126648820377

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
894.0, 355.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
457.0, 287.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 490.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
68.13745936343167, 70.62945679599147

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.0, 571.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0588235294117, 602.7647058823529

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 631.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.4262408218646, 805.8784275570199

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0, 859.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.0, 310.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
756.0, 1007.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 287.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
107.39084770885086, 619.0619226222382

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
47.0, 611.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
100.0, 611.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.9965420357148, 985.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
202.0, 611.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
263.0, 1000.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.0, 744.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
825.0, 863.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
893.9698918137259, 836.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
825.0, 976.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.0, 291.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.3134845335628, 971.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
863.8674523492571, 992.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 1042.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.0, 1043.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.50986776965385, 1051.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
279.0, 1086.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.1666347805742, 1156.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.90423049601816, 1103.3981535963594

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back