1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/17981503.csml convertedTime:2009.07.01.11:09

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Anti-inflammatory actions of PPAR ligands: new insights on cellular andmolecular mechanisms.
Authors Straus DS, Glass CK.
Affiliation Biomedical Sciences Division, University of California, Riverside, Riverside, CA92521-0121, USA. daniel.straus@ucr.edu
Abstract The peroxisome proliferator-activated receptors (PPARalpha, -gamma, and-beta/delta) are nuclear receptors with distinct patterns of expression in manycell types both within and outside the immune system. PPAR ligands haveanti-inflammatory activity in a variety of mouse models for acute and chronicinflammation. In macrophages, PPARgamma ligands repress expression of a subsetof Toll-like receptor (TLR) target genes by a molecular mechanism termedligand-dependent transrepression. In chronic inflammation, ligand-boundPPARalpha represses production of IFNgamma and IL-17 by CD4(+) T cells, andPPARgamma ligands modulate dendritic cell function to elicit the development ofanergic CD4(+) T cells. PPAR ligands also repress expression of cell adhesionmolecules on endothelial cells and the secretion of chemokines by epithelial andother cells, decreasing the recruitment of leukocytes to the site ofinflammation. The anti-inflammatory activity of PPAR ligands in mouse modelssuggests their possible use for treating human inflammatory and autoimmunediseases.
PMID 17981503
Model Abstract

Entity

G010430:VCAM-1 G010431:ICAM-1 G010453:IFN-gamma G010514:iNOS G010522:RANTES G010625:Egr1 G010691:CD40 G010815:MCP1 G011221:CCR7 G012252:CXCL10 G027461:CD83 G027553:CD1A MO000000049:c-Jun MO000000193:RelA-p65 MO000000204:TNF MO000000289:TNF-alpha MO000004687:ERK5 MO000007327:IL-17 MO000016632:p50:RelA-p65 MO000016882:LPS MO000017265:IL-12 MO000017464:RXR MO000017700:PIAS1 MO000019394:TLR4 MO000019843:CXCR3 MO000019881:RANTES MO000019971:SUMO-1 MO000019972:Ubc9 MO000021732:glucocorticoids MO000034742:BCL-6 MO000042976:HDAC4 e1: e10:CXCL1 e11:PPRE e12:PPAR-alpha:RXR:PPRE e13:Troglitazone e14:PPAR-gamma e15:PPAR-gamma:Troglitazone e16:GW0742 e17:PPAR-delta e18:NCoR:HDAC3:TBL1:TBLR1 e19:iNOS e2: e20:LPS:TLR4 e21:p50:RelA-p65:IkappaB e22:p50:RelA-p65:IkappaB{active} e23:Degradants e24:p50:RelA-p65 e25:19s proteosome e26:NCoR:HDAC3:TBL1:TBLR1{ub} e27:proteosome degradants e28:p50:RelA-p65:iNOS e29:Activator complex e3: e30:p50:RelA-p65:iNOS:Activator complex e31:PPAR-gamma:troglitazone:SUMO-1 e32:NCoR:HDAC3:TBL1:TBLR1:PPAR-gamma:Troglitazone:SUMO-1 e33:PPAR-gamma:RCXR e34:Inflammatory response gene mRNA e35:RelA-p65:PPAR-alpha e36:PPARdelta:BCL-6 e37:PPARdelta:GW0742 e38:LXRalpha e39:LXRbeta e4: e40:Ligand e41:LXRalpha:Ligand e42:LXRbeta:Ligand e43:SUMO-2 e44:SUMO-3 e45:LXRalpha:ligand:SUMO-2:SUMo-3 e46:LXRalpha:ligand:SUMO-2:SUMo-3:NCor co-repressor complex e47:LXRbeta:ligand:SUMO-2:SUMo-3 e48:LXRbeta:ligand:SUMO-2:SUMo-3:NCor co-repressor complex e49:GR ligand e5:PPAR-alpha e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:PPAR-alpha:RXR e60: e61: e62: e63:Glucocorticoids:GR ligand e64:Glucocorticoids:GRligand:RelA-p65 e65:IL-8 e66:c-Jun:PPAR-alpha e67:IL-12 e68:CXCL10 e69:Fenofibrate e7: e70:PPAR-alpha:Fenofibrate e71:Wy14643 e72:PPARalpha:Wy14643 e73:IL-17 e74:ICAM-2 e75:CXCL8 e76:GW7647 e77:PPARgamma:GW7845 e78:CXCL9 e79:CCL2 e8: e80:CCL4 e81:CCL7 e82:CCl12 e83:CCL17 e84:CCL19 e85:GW7647 e86:PPAR-alpha:GW7647 e87:CXCL10:CXCR3 e88:CXCL9 e89:CXCL9:CXCR3 e9: e90:CXCL11 e91:CXCL11 e92:CXCL11:CXCR3 e93:ROS e94:PPARgamma e95:PPAR-delta:ERK5

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p8 p9
Model Detail
733.0, 1361.0
22.5, 22.5

VCAM-1

--

G010430

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p47

--

true true true true

csml-variable:Double

m93402

10

false

infinite

0

unit false false false
TRANSFACG010430

--

Go back
587.0, 1399.0
26.0, 26.0

ICAM-1

--

G010431

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m93403

10

false

infinite

0

unit false false false
TRANSFACG010431

--

Go back
317.0, 1237.0
22.0, 22.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p42

--

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
862.0, 938.0
28.0, 28.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p6 p7 p16

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
832.0, 1316.0
24.0, 24.0

RANTES

--

G010522

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m93487

10

false

infinite

0

unit false false false
TRANSFACG010522

--

Go back
387.0, 1419.0
26.0, 26.0

Egr1

--

G010625

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p67

--

true true true true

csml-variable:Double

m93569

10

false

infinite

0

unit false false false
TRANSFACG010625

--

Go back
535.0, 1051.0
25.5, 25.5

CD40

--

G010691

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m93612

10

false

infinite

0

unit false false false
TRANSFACG010691

--

Go back
615.0, 815.0
25.5, 25.5

MCP1

--

G010815

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4

--

true true true true

csml-variable:Double

m93710

10

false

infinite

0

unit false false false
TRANSFACG010815

--

Go back
740.0, 1108.0
31.0, 31.0

CCR7

--

G011221

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m94106

10

false

infinite

0

unit false false false
TRANSFACG011221

--

Go back
849.0, 1281.0
22.0, 22.0

CXCL10

--

G012252

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p49 p59 p62

p39

true true true true

csml-variable:Double

m95041

10

false

infinite

0

unit false false false
TRANSFACG012252

--

Go back
571.0, 1199.0
26.5, 26.5

CD83

--

G027461

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m106162

10

false

infinite

0

unit false false false
TRANSFACG027461

--

Go back
641.0, 1149.0
22.0, 22.0

CD1A

--

G027553

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m106254

10

false

infinite

0

unit false false false
TRANSFACG027553

--

Go back
905.0, 385.0
22.0, 22.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
651.0, 527.0
18.0, 18.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p31

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
1177.0, 1145.0
22.0, 22.0

TNF

--

MO000000204

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m175

10

false

infinite

0

unit false false false
TRANSPATHMO000000204

--

Go back
1166.0, 1066.0
22.0, 22.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p46 p47 p62 p63 p65

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
524.0, 512.0
24.0, 24.0

ERK5

--

MO000004687

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m564

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004687

--

Go back
1185.0, 1381.0
22.0, 22.0

IL-17

--

MO000007327

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m840

10

false

infinite

0

unit false false false
TRANSPATHMO000007327

--

Go back
849.0, 725.0
22.0, 22.0

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p11

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
1189.0, 557.0
22.0, 22.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1175.0, 1215.0
18.0, 18.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
684.0, 740.0
16.0, 16.0

RXR

--

MO000017464

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p19

true true true true

csml-variable:Double

m2283

10

false

infinite

0

unit false false false
TRANSPATHMO000017464

--

Go back
329.0, 561.0
19.0, 19.0

PIAS1

--

MO000017700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m2460

10

false

infinite

0

unit false false false
InterProIPR004181
TRANSPATHMO000017700

--

Go back
1090.0, 590.0
20.0, 20.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1072.0, 1444.0
24.0, 24.0

CXCR3

--

MO000019843

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61 p64 p66

true true true true

csml-variable:Double

m4372

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000019843

--

Go back
1174.0, 1326.0
20.0, 20.0

RANTES

--

MO000019881

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m4410

10

false

infinite

0

unit false false false
InterProIPR000827
TRANSPATHMO000019881

--

Go back
293.0, 612.0
29.796097347073008, 15.394650295987718

SUMO-1

--

MO000019971

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m4499

10

false

infinite

0

unit false false false
InterProIPR000626
TRANSPATHMO000019971

--

Go back
409.0, 537.0
22.0, 22.0

Ubc9

--

MO000019972

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p26 p28

true true true true

csml-variable:Double

m4500

10

false

infinite

0

unit false false false
TRANSPATHMO000019972

--

Go back
815.0, 411.0
18.0, 18.0

glucocorticoids

--

MO000021732

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m6069

10

false

infinite

0

unit false false false
TRANSPATHMO000021732

--

Go back
606.0, 466.0
20.0, 20.0

BCL-6

--

MO000034742

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p22

true true true true

csml-variable:Double

m13276

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000034742

--

Go back
702.0, 1590.0
20.0, 20.0

HDAC4

--

MO000042976

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p28

true true true true

csml-variable:Double

m20760

10

false

infinite

0

unit false false false
TRANSPATHMO000042976

--

Go back
32.28435699983014, 245.3725829752728
1094.8757312552095, 1589.7595617825657

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
722.0, 1188.0
43.91003460207612, 23.418685121107266

CXCL1

--

e10

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p51

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
590.0, 861.5
60.0, 13.0

PPRE

--

e11

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p2

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
618.0, 904.5
52.87220365132424, 14.980457701208536

PPAR-alpha:RXR:PPRE

--

e12

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p2

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
328.0, 788.0
40.647603027754414, 23.033641715727498

Troglitazone

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
308.5, 660.0
15.294425437713826, 24.80177098007647

PPAR-gamma

--

e14

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p69

p3 p19 p50 p67

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
458.5, 756.0
18.98433594400933, 23.246125645725712

PPAR-gamma:Troglitazone

--

e15

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p3

p4 p18 p34 p35 p36 p37 p38 p39 p40

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
503.0, 556.0
41.253153910849456, 23.376787216148024

GW0742

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Nucleoplasm

--

--

p5 p23

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
617.0, 591.0
14.459307764265667, 33.36763330215154

PPAR-delta

--

e17

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p5 p22 p70

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
714.0, 1047.0
20.205882352941174, 33.67647058823529

NCoR:HDAC3:TBL1:TBLR1

--

e18

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p7 p12 p17 p27 p29

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
658.0, 937.5
60.0, 13.0

iNOS

--

e19

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p7 p14

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
32.28435699983014, 245.3725829752728
1094.8757312552095, 1589.7595617825657

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1088.5, 647.0
22.001096250822187, 42.5827669370752

LPS:TLR4

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p6 p9 p18 p51 p52 p49 p53 p54 p55 p56 p57 p58 p62 p63 p65

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1000.5, 553.0
22.040557900532207, 30.75426683795191

p50:RelA-p65:IkappaB

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
848.5, 553.0
22.040557900532207, 30.75426683795191

p50:RelA-p65:IkappaB{active}

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
943.0, 720.0
25.692130959218844, 24.835726593911545

Degradants

--

e23

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
761.0, 833.0
22.0, 22.0

p50:RelA-p65

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p14 p32

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
800.0, 1095.5
23.519999999999996, 17.64

19s proteosome

--

e25

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p12

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
914.0, 1035.0
20.205882352941174, 33.67647058823529

NCoR:HDAC3:TBL1:TBLR1{ub}

--

e26

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p12

p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
769.0, 989.0
21.935669155657664, 21.20448018380241

proteosome degradants

--

e27

cso30:c:EntityBiological

cso30:i:CC_Nucleoplasm

--

p13

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
802.0, 895.5
60.0, 17.0

p50:RelA-p65:iNOS

--

e28

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p14

p15

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
584.0, 934.0
16.85294117647059, 28.088235294117652

Activator complex

--

e29

cso30:c:Complex

cso30:i:CC_Nucleolus

--

--

p15

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
54.18187162493432, 267.2700976003772
1051.0807020050004, 1545.9645325323575

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
494.0, 1003.5
60.0, 17.0

p50:RelA-p65:iNOS:Activator complex

--

e30

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p15

p16

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
401.5, 933.0
21.48816296568178, 29.98348320792806

PPAR-gamma:troglitazone:SUMO-1

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p17 p19

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
458.0, 1035.0
20.205882352941174, 33.67647058823529

NCoR:HDAC3:TBL1:TBLR1:PPAR-gamma:Troglitazone:SUMO-1

--

e32

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p17

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
463.5, 673.0
17.481919680053327, 21.406432261289787

PPAR-gamma:RCXR

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
419.0, 1082.0
50.96885813148789, 27.18339100346021

Inflammatory response gene mRNA

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p20

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
794.5, 580.0
19.07415430761539, 23.356107315447417

RelA-p65:PPAR-alpha

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
474.5, 496.0
19.02516247292118, 23.296117313781046

PPARdelta:BCL-6

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p20 p23

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
430.5, 428.0
18.968005332444594, 23.226128978503585

PPARdelta:GW0742

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
164.11687170474517, 1509.9490333919157
22.93848857644991, 35.28998242530756

LXRalpha

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20 p24

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
289.5, 1479.0
21.72759226713532, 33.42706502636204

LXRbeta

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20 p25

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
94.69227368137729, 305.5907481943091
970.0598978921154, 1469.323231344493

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
151.0, 1404.5
25.707385791909843, 15.852887905011068

Ligand

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24 p25

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
408.5, 1510.0
22.64678798509099, 43.832492874369656

LXRalpha:Ligand

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p26

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
372.5, 1562.0
22.64678798509099, 43.832492874369656

LXRbeta:Ligand

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p28

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
724.0, 1547.5
23.36, 17.519999999999996

SUMO-2

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26 p28

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
601.5, 1593.0
13.93922318373919, 22.604145703360842

SUMO-3

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26 p28

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
641.0, 1278.0
21.44117647058824, 35.735294117647065

LXRalpha:ligand:SUMO-2:SUMo-3

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p27

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
773.0, 1258.0
21.44117647058824, 35.735294117647065

LXRalpha:ligand:SUMO-2:SUMo-3:NCor co-repressor complex

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
361.0, 1206.0
21.44117647058824, 35.735294117647065

LXRbeta:ligand:SUMO-2:SUMo-3

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
421.0, 1182.0
21.44117647058824, 35.735294117647065

LXRbeta:ligand:SUMO-2:SUMo-3:NCor co-repressor complex

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
648.0, 386.5
20.799999999999997, 15.599999999999996

GR ligand

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
624.0, 667.5
23.039999999999996, 17.280000000000005

PPAR-alpha

--

e5

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p1 p21 p33 p41 p43 p60

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
177.72780655252342, 779.361406786949
813.8144682211365, 738.0403091688905

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
265.62583105313007, 796.8518891724084
475.8617188481138, 715.3080614532166

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
188.33618881983801, 789.2120474637413
792.5977036865081, 718.3390278153063

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
189.8516720008829, 790.7275306447862
789.5667373244174, 715.3080614532166

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
177.72780655252342, 779.361406786949
813.8144682211365, 738.0403091688905

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
177.72780655252342, 779.361406786949
813.8144682211365, 738.0403091688905

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
189.8516720008829, 790.7275306447862
789.5667373244174, 715.3080614532166

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
771.7972135221428, 1082.4580429959396
50.842656467545616, 46.02598374956775

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
638.4346935901872, 1294.6256883422313
143.97090219927006, 130.33155356986578

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
177.72780655252342, 779.361406786949
813.8144682211365, 738.0403091688905

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
643.5, 714.0
16.45309115147476, 20.146642226295622

PPAR-alpha:RXR

--

e6

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p1

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
369.53929769341323, 1107.3404217043253
25.77230843381114, 12.408889245909098

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
368.6786873641868, 1070.3341775475806
88.2125587457294, 158.78260574231317

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
405.68493152093265, 1173.6074170547777
13.769765267626035, 13.769765267626079

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
774.0, 497.0
19.83977900552486, 22.044198895027634

Glucocorticoids:GR ligand

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31 p32

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
853.5, 466.0
20.58065700128464, 28.717195815746003

Glucocorticoids:GRligand:RelA-p65

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
776.0, 1147.0
47.491349480968864, 25.32871972318339

IL-8

--

e65

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
990.5, 445.0
18.314780869855014, 22.426262289618386

c-Jun:PPAR-alpha

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
856.0, 1217.0
40.9515570934256, 21.840830449826992

IL-12

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p38

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1178.0, 1270.0
12.416276894293734, 28.652946679139387

CXCL10

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p39

p61

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
214.0, 417.0
52.00168208578637, 29.467619848612276

Fenofibrate

--

e69

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
194.0, 289.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
197.5, 543.0
20.82152974504249, 25.495750708215304

PPAR-alpha:Fenofibrate

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42 p44 p59

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
135.0, 860.0
42.237174095878885, 23.93439865433137

Wy14643

--

e71

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
289.5, 819.0
20.601066488918512, 25.225795700716553

PPARalpha:Wy14643

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p42 p47

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
303.0, 1279.0
34.515570934256054, 18.408304498269896

IL-17

--

e73

cso30:c:SmallMolecule

cso30:i:CC_Nucleoplasm

--

p44

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
660.0, 1389.0
39.653979238754324, 21.148788927335644

ICAM-2

--

e74

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
748.0, 1325.0
40.69204152249135, 21.70242214532872

CXCL8

--

e75

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p48

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
143.0, 600.0
41.00084104289318, 23.233809924306136

GW7647

--

e76

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p50

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
163.5, 726.0
20.184635894017664, 24.715880686552246

PPARgamma:GW7845

--

e77

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p50

p51 p52 p49 p53 p54 p55 p56 p57 p58

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
383.0, 1303.0
33.63321799307959, 17.937716262975776

CXCL9

--

e78

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p52 p63

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
503.0, 1365.0
42.71626297577855, 22.782006920415228

CCL2

--

e79

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p53

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
193.27783640210245, 292.0276678214232
875.097159093833, 1270.6410750042462

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
478.0, 1172.0
43.28719723183391, 23.08650519031142

CCL4

--

e80

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p54

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
332.0, 1349.0
40.89965397923876, 21.813148788927336

CCL7

--

e81

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p55

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
443.0, 1317.0
41.36678200692042, 22.062283737024224

CCl12

--

e82

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p56

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
924.0, 1114.0
39.23875432525952, 20.927335640138413

CCL17

--

e83

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p57

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
217.0, 1106.0
37.83737024221453, 20.179930795847753

CCL19

--

e84

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p58

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
807.0, 636.0
41.22792262405382, 23.36248948696383

GW7647

--

e85

cso30:c:SmallMolecule

cso30:i:CC_Cytoplasm

--

--

p60

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
786.5, 760.0
18.89451758040327, 23.136143976004004

PPAR-alpha:GW7647

--

e86

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p60

p59

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1074.5, 1501.0
19.96206972155229, 38.63626397719798

CXCL10:CXCR3

--

e87

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p61

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1173.5, 1514.0
13.931777017508553, 22.59207083920306

CXCL9

--

e88

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p64

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
1074.5, 1565.0
19.96206972155229, 38.63626397719798

CXCL9:CXCR3

--

e89

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p64

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
94.15331142642546, 320.5339069018661
1011.299036118793, 1455.7949234541122

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
643.0, 1449.0
42.352941176470594, 22.588235294117652

CXCL11

--

e90

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p65

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1168.0, 1634.5
24.960000000000004, 18.72

CXCL11

--

e91

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p66

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1077.5, 1644.0
20.97478623108967, 40.59636044727033

CXCL11:CXCR3

--

e92

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p66

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1139.0, 996.0
47.1825063078217, 26.736753574432292

ROS

--

e93

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p68

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
201.0, 1144.0
46.193771626297575, 24.636678200692042

PPARgamma

--

e94

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p68

p69

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
455.5, 365.0
24.70004999166806, 30.24495917347109

PPAR-delta:ERK5

--

e95

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p70

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
737.0, 617.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000017464 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c1 : 1
stoichiometry:c3 : 1

m2283*m5*0.1

nodelay

--

true

0

false

PMID: 17981503,15629253,15860371 They form heterodimers with the retinoid X receptor (RXR) and activate transcription by binding to a specific DNA element termed the PPAR response element (PPRE)

Go back
849.0, 661.0
21.0, 21.0

p10

p10

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e22

MO000016632 e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 17981503 When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.

Go back
851.0, 787.0
18.0, 18.0

p11

p11

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016632

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 17981503 When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.

Go back
802.0, 1042.0
19.0, 19.0

p12

p12

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

e18 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m18*m25*0.1

nodelay

--

true

0

false

PMID: 17981503 Concomitant with these events, the corepressor complex is ubiquitinated and degraded by the 19 S proteasome.

Go back
794.0, 946.0
19.0, 19.0

p13

p13

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleolus

--

e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 17981503 Concomitant with these events, the corepressor complex is ubiquitinated and degraded by the 19 S proteasome.

Go back
678.0, 854.0
19.0, 19.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e24 e19

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m24*m19*0.1

nodelay

--

true

0

false

PMID: 17981503 NF-KappaB p65-p50 heterodimers bind to the KappaB element located in the iNOS promoter, facilitating the recruitment of coactivator complexes and activation of iNOS gene transcription.

Go back
654.0, 978.0
19.0, 19.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e29 e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m29*m28*0.1

nodelay

--

true

0

false

PMID: 17981503 NF-KappaB p65-p50 heterodimers bind to the KappaB element located in the iNOS promoter, facilitating the recruitment of coactivator complexes and activation of iNOS gene transcription.

Go back
694.0, 1010.0
19.0, 19.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 17981503 NF-KappaB p65-p50 heterodimers bind to the KappaB element located in the iNOS promoter, facilitating the recruitment of coactivator complexes and activation of iNOS gene transcription.

Go back
458.0, 922.0
19.0, 19.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e31 e18

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m31*m18*0.1

nodelay

--

true

0

false

PMID: 17981503,16127449 The SUMOylated PPARgamma binds to NCoR and interferes with clearance of the corepressor complex, thereby maintaining the promoter in the repressed state

Go back
402.0, 626.0
19.0, 19.0

p18

p18

cso30:i:ME_Sumoylation

cso30:i:CC_Cytosol

--

MO000019971 e15 e20 MO000019972 MO000017700

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c45 : 1

m4499*m15*m20*m4500*m2460*0.1

nodelay

--

true

0

false

PMID: 17981503 In cells treated with PPARgamma ligand plus LPS, ligand binding triggers conjugation of a small fraction of cellular PPARgamma with SUMO1 (small ubiquitin-like modifier) on lysine 365 (K365), mediated by the SUMOylation pathway E2 ligase Ubc9 and E3 ligase PIAS1 PMID: 17981503 Figure 2

Go back
558.0, 726.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e14 MO000017464 e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c55 : 1
stoichiometry:c54 : 1

m14*m2283*0.1

nodelay

--

true

0

false

PMID: 17981503 SUMOylation of PPARgamma is predicted to prevent its heterodimerization with RXR, thereby dedicating this form of PPARgamma to a repressor function.

Go back
671.0, 807.0
18.0, 18.0

p2

p2

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

MO000017464 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m2283*m11*0.1

nodelay

--

true

0

false

PMID: 17981503, 15629253, 15860371 They form heterodimers with the retinoid X receptor (RXR) and activate transcription by binding to a specific DNA element termed the PPAR response element (PPRE)

Go back
594.0, 1086.0
19.0, 19.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e36 e38 e39

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c67 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503,12970571 Binding of ligand to PPARdelta releases BCL-6, which then represses inflammatory-response genes PMID: 17981503,17218271 The liver X receptors (LXRalpha and -beta) repress a subset of inflammatory-response genes that overlaps with, yet is distinct from, the subset repressed by PPARgamma

Go back
654.0, 582.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000193 e5

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m166*m5*0.1

nodelay

--

true

0

false

PMID: 17981503,10542237 Direct binding of PPARalpha to NF-KappaB p65 was demonstrated by in vitro assays, suggesting that transrepression might involve direct interference with transcriptional activation by NF-KappaB

Go back
522.0, 422.0
19.0, 19.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000034742 e17

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m13276*m17*0.1

nodelay

--

true

0

false

PMID: 17981503 For PPARdelta, a novel mechanism for transrepression was identified that involves binding and sequestration of the transcriptional repressor BCL-6 by unliganded PPARdelta.

Go back
317.0, 469.0
19.0, 19.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 e16

e37 MO000034742

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m36*m16*0.1

nodelay

--

true

0

false

PMID: 17981503,12970571 Binding of ligand to PPARdelta releases BCL-6, which then represses inflammatory-response genes

Go back
229.0, 1409.0
21.0, 21.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 e40

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m38*m40*0.1

nodelay

--

true

0

false

PMID: 17981503 Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3.

Go back
261.0, 1557.0
21.0, 21.0

p24

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 e39

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m40*m39*0.1

nodelay

--

true

0

false

PMID: 17981503 Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3.

Go back
413.0, 1361.0
21.0, 21.0

p26

p26

cso30:i:ME_Sumoylation

cso30:i:CC_Cytosol

--

e41 e43 e44 MO000019972 MO000042976

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m41*m43*m44*m4500*m20760*0.1

nodelay

--

true

0

false

PMID: 17981503 Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3 PMID: 17981503 Here, the E3 ligase is HDAC4 rather than PIAS1.

Go back
670.0, 1198.0
19.0, 19.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Nucleolus

--

e45 e18

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m45*m18*0.1

nodelay

--

true

0

false

PMID: 17981503 As with PPARgamma, SUMOylated LXR interferes with clearance of NCoR-containing corepressor complexes from the promoters of target genes.

Go back
501.0, 1561.0
21.0, 21.0

p26

p28

cso30:i:ME_Sumoylation

cso30:i:CC_Cytosol

--

e42 e44 e43 MO000042976 MO000019972

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m42*m44*m43*m20760*m4500*0.1

nodelay

--

true

0

false

PMID: 17981503 Binding of ligand to the LXRs triggers covalent conjugation with SUMO2 and -3 PMID: 17981503 Here, the E3 ligase is HDAC4 rather than PIAS1.

Go back
522.0, 1210.0
19.0, 19.0

p27

p29

cso30:i:ME_Binding

cso30:i:CC_Nucleolus

--

e47 e18

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m47*m18*0.1

nodelay

--

true

0

false

PMID: 17981503 As with PPARgamma, SUMOylated LXR interferes with clearance of NCoR-containing corepressor complexes from the promoters of target genes.

Go back
338.0, 710.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m14*0.1

nodelay

--

true

0

false

PMID: 17981503,12110006,17631136 For example, the PPAR¦Ã ligand troglitazone increased expression of the chemokine MCP-1 (CCL2) and enhanced monocyte/macrophage infiltration in a rat model of glomerulonephritis, and the PPAR¦Ä ligand GW0742 worsened the course of colitis in IL-10-deficient mice

Go back
711.0, 411.0
17.0, 17.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000021732

e63 e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c99 : 1

m49*m6069*0.1

nodelay

--

true

0

false

PMID: 17981503,16127449,17072333 Ligand-bound GR interacts strongly with the p65 subunit of NF-KappaB, in contrast to ligand-bound PPARgamma, which interacts very weakly with p65

Go back
699.0, 499.0
17.0, 17.0

p30

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000193 e63

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m166*m63*0.1

nodelay

--

true

0

false

PMID: 17981503,16127449,17072333 Ligand-bound GR interacts strongly with the p65 subunit of NF-KappaB, in contrast to ligand-bound PPARgamma, which interacts very weakly with p65

Go back
870.0, 1150.0
19.0, 19.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000204 e24 e63

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c101 : 1

m175*m24*0.1

nodelay

--

true

0

false

PMID: 17981503,15879558 Interestingly, repression by GR of tumor necrosis factor (TNF)-stimulated gene transcription in A549 lung adenocarcinoma cells is also target-gene specific: some NF-KappaB-dependent genes such as IL-8 (CXCL8) are repressed, whereas others, such as IKappaBalpha, are not

Go back
905.0, 457.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000049 e5

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m66*m5*0.1

nodelay

--

true

0

false

PMID: 17981503,10542237,14609950 In the case of AP-1, several mechanisms for transrepression by nuclear receptors have been identified, including inhibition of c-Jun N-terminal kinase (JNK) signaling by GR, and direct interaction of PPARalpha with c-Jun, resulting in interference with transcriptional activation

Go back
625.0, 1069.0
21.0, 21.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G027553

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503,12133943,17475839,17277116 PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)

Go back
541.0, 949.0
21.0, 21.0

p34

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G010691

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503,12133943,17475839,17277116 PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)

Go back
525.0, 1117.0
21.0, 21.0

p34

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G027461

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503,12133943,17475839,17277116 PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)

Go back
661.0, 1069.0
21.0, 21.0

p34

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

G011221

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503,12133943,17475839,17277116 PPARgamma ligands inhibit DC maturation and repress the expression by DC of CD1a, CD40, CD83, CCR7, and the costimulatory molecule CD80 (B7.1)

Go back
1026.0, 1222.0
19.0, 19.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e67 e15

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c119 : 1
stoichiometry:c116 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 17981503,12133943,17192567 PPARgamma ligands also repress DC production of IL-12 and several chemokines, including CXCL10 and RANTES

Go back
1010.0, 1270.0
19.0, 19.0

p38

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G012252 e15

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c120 : 1
stoichiometry:c118 : 1

m95041*0.1

nodelay

--

true

0

false

PMID: 17981503,12133943,17192567 PPARgamma ligands also repress DC production of IL-12 and several chemokines, including CXCL10 and RANTES

Go back
463.0, 895.0
17.0, 17.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e15

G010815

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 17981503,12110006,17631136 For example, the PPARgamma ligand troglitazone increased expression of the chemokine MCP-1 (CCL2) and enhanced monocyte/macrophage infiltration in a rat model of glomerulonephritis, and the PPARdelta ligand GW0742 worsened the course of colitis in IL-10-deficient mice

Go back
966.0, 1330.0
19.0, 19.0

p38

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010522 e15

MO000019881

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m93487*0.1

nodelay

--

true

0

false

PMID: 17981503,12133943,17192567 PPARgamma ligands also repress DC production of IL-12 and several chemokines, including CXCL10 and RANTES

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261.0, 497.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m5*m70*0.1

nodelay

--

true

0

false

PMID: 17981503,11934839 The PPARalpha ligand fenofibrate represses IFNgamma expression in anti-CD3-treated cultured human CD4+ lymphocytes

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330.0, 1158.0
19.0, 19.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e70 e72

G010453

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c132 : 1
stoichiometry:c128 : 1

1.0*0.1

nodelay

--

true

0

false

--

Go back
249.0, 745.0
21.0, 21.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 e5

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m72*m5*0.1

nodelay

--

true

0

false

PMID: 17981503,11884448 Similarly, another PPARalpha ligand, Wy14643, represses IFNgamma in activated mouse splenocytes

Go back
294.0, 1110.0
19.0, 19.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e70

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503,17631136 More recently, fenofibrate has been shown to repress IL-17 expression in cultured splenocytes activated by PMA plus ionomycin and by Th17 cells in a pathogenic CD4+ T-cell line cultured from C3H Bir mice treated with cecal bacterial antigens

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553.0, 1301.0
21.0, 21.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearEnvelopeLumen

--

MO000000289

G010431

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c136 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 17981503 Expression of the adhesion molecules ICAM-1, and -2, and VCAM-1 is induced by proinflammatory cytokines, including TNFalpha. PMID: 17981503,10377075,16115476,16439686 PPARalpha is expressed in vascular endothelial cells, and PPARalpha ligands repress TNFalpha-elicited expression of VCAM-1 by these cells

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613.0, 1317.0
21.0, 21.0

p45

p46

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearEnvelopeLumen

--

MO000000289

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c138 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 17981503 Expression of the adhesion molecules ICAM-1, and -2, and VCAM-1 is induced by proinflammatory cytokines, including TNFalpha. PMID: 17981503,10377075,16115476,16439686 PPARalpha is expressed in vascular endothelial cells, and PPARalpha ligands repress TNFalpha-elicited expression of VCAM-1 by these cells

Go back
681.0, 1317.0
21.0, 21.0

p45

p47

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearEnvelopeLumen

--

e72 MO000000289

G010430

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c141 : 1
stoichiometry:c137 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 17981503 Expression of the adhesion molecules ICAM-1, and -2, and VCAM-1 is induced by proinflammatory cytokines, including TNFalpha. PMID: 17981503,10377075,16115476,16439686 PPARalpha is expressed in vascular endothelial cells, and PPARalpha ligands repress TNFalpha-elicited expression of VCAM-1 by these cells

Go back
810.0, 1366.0
19.0, 19.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000007327

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m840*0.1

nodelay

--

true

0

false

PMID: 17981503,16798734 Interestingly, the proinflammatory cytokine IL-17 induces CXCL8 gene transcription and also stabilizes CXCL8 mRNA via a p38 MAP kinase-dependent pathway

Go back
782.0, 1190.0
19.0, 19.0

p51

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e77

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c155 : 1
stoichiometry:c154 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%. PMID: 17981503,17486092 For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11 PMID: 17981503,11208713 Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha

Go back
502.0, 662.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e16 e17

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m16*m17*0.1

nodelay

--

true

0

false

PMID: 17981503,12110006,17631136 For example, the PPARgamma ligand troglitazone increased expression of the chemokine MCP-1 (CCL2) and enhanced monocyte/macrophage infiltration in a rat model of glomerulonephritis, and the PPAR¦Ä ligand GW0742 worsened the course of colitis in IL-10-deficient mice

Go back
157.0, 661.0
21.0, 21.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e76 e14

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m77*m14*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
638.0, 1190.0
19.0, 19.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77 e20

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c153 : 1
stoichiometry:c149 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
386.0, 1158.0
19.0, 19.0

p51

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77 e20

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
510.0, 1298.0
19.0, 19.0

p51

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e77

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c158 : 1
stoichiometry:c157 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
482.0, 1114.0
19.0, 19.0

p51

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e77

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c159 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
270.0, 1294.0
19.0, 19.0

p51

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77 e20

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
398.0, 1234.0
19.0, 19.0

p51

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77 e20

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c165 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
870.0, 1070.0
19.0, 19.0

p51

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20 e77

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c170 : 1
stoichiometry:c169 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
254.0, 1038.0
19.0, 19.0

p51

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77 e20

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c171 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 17981503,16143103 In a recent microarray survey of genes highly induced by LPS in mouse macrophages, the PPARgamma ligand GW7845 repressed expression of several chemokine genes, including those encoding CXCL1, -9, and -10 as well as CCL2, -4, -7, -12, -17, and -19, by >40%.

Go back
760.0, 1412.0
16.0, 16.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e70 e86

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c179 : 1
stoichiometry:c175 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503,17631136 The PPARalpha ligands fenofibrate and GW7647 also repress CXCL10 mRNA expression and promoter activity in human HT-29 cells, a model for colonic epithelial cells

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934.0, 1022.0
20.0, 20.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c15 : 1

m20*0.1

nodelay

--

true

0

false

PMID:17981503,16127449 Repression of lipopolysaccharide (LPS)-induced iNOS (NOS2) gene expression in macrophages has been characterized in detail

Go back
765.0, 673.0
19.0, 19.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e5 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m5*m86*0.1

nodelay

--

true

0

false

PMID: 17981503,17631136 The PPARalpha ligands fenofibrate and GW7647 also repress CXCL10 mRNA expression and promoter activity in human HT-29 cells, a model for colonic epithelial cells

Go back
1130.0, 1434.0
19.0, 19.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e68 MO000019843

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m69*m4372*0.1

nodelay

--

true

0

false

PMID: 17981503,17486092 For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11

Go back
910.0, 1246.0
19.0, 19.0

p51

p62

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000289 e20

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m230*m20*0.1

nodelay

--

true

0

false

PMID: 17981503,17486092 For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11 PMID: 17981503,11208713 Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha

Go back
218.0, 1238.0
19.0, 19.0

p51

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000289 e20

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c186 : 1

m230*m20*0.1

nodelay

--

true

0

false

PMID: 17981503,11208713 Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha

Go back
1170.0, 1458.0
19.0, 19.0

p61

p64

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019843 e88

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m4372*m89*0.1

nodelay

--

true

0

false

PMID: 17981503,17486092 For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11

Go back
714.0, 1418.0
19.0, 19.0

p51

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000289 e20

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c192 : 1

m230*m20*0.1

nodelay

--

true

0

false

PMID: 17981503,11208713 Expression of these chemokines is highly induced by the combination of IFNgamma and TNFalpha

Go back
1166.0, 1578.0
19.0, 19.0

p61

p66

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019843 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m4372*m92*0.1

nodelay

--

true

0

false

PMID: 17981503,17486092 For example, in chronic inflammatory diseases perpetuated by effector T cells, activated Th1 cells are attracted to the site of inflammation by chemokines that interact with the CXCR3 receptor, including CXCL9, -10, and -11

Go back
380.0, 1332.0
23.0, 23.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G010625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c198 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 17981503 PPARgamma then represses expression of the inflammatory-response gene Egr-1.

Go back
366.0, 1094.0
19.0, 19.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c200 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 17981503,16713977 Recently, suppression of the inflammatory response by CO in macrophages has been ascribed to a CO-mediated burst of reactive oxygen species, which induce the expression of PPARgamma

Go back
145.0, 945.0
23.0, 23.0

p69

p69

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e94

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m95*0.1

nodelay

--

true

0

false

PMID: 17981503,16713977 Recently, suppression of the inflammatory response by CO in macrophages has been ascribed to a CO-mediated burst of reactive oxygen species, which induce the expression of PPARgamma

Go back
761.0, 913.0
22.0, 22.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18 e19

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 17981503 In the ¡Èoff¡É state, the iNOS gene is actively repressed by a multisubunit complex containing NCoR, histone deacetylase 3 (HDAC3), TBL1, and TBLR1.

Go back
552.0, 388.0
23.0, 23.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000004687 e17

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m564*m17*0.1

nodelay

--

true

0

false

PMID: 17981503,16943204 Recent studies have demonstrated that PPARdelta binds to ERK5 and is required for ERK5-mediated repression of NF-KappaB

Go back
1191.0, 659.0
17.0, 17.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019394

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 17981503 When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.

Go back
937.0, 609.0
21.0, 21.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m20*m21*0.1

nodelay

--

true

0

false

PMID: 17981503 When LPS binds to TLR4, the NF-KappaB signaling pathway is activated, IKappaB is degraded, and NF-KappaB p65-p50 heterodimers enter the nucleus.

Go back
647.0, 636.1117762963229

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 779.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.9992285066764, 1156.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
831.0, 1160.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 855.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
786.0, 519.0

c103

c103

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
916.0, 407.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.0, 480.77608615456165

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.0, 458.21645747403153

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.0, 779.0

c107

c107

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
638.0, 1090.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
473.0, 779.0

c109

c109

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
480.0, 837.5136810560396

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
549.296093284079, 970.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
470.0, 779.0

c111

c111

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
542.0, 1138.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.0, 779.0

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
682.0, 1085.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.0, 1229.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1045.0, 1224.4301460975425

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.0, 1281.5740559105661

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1029.0, 1280.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.0, 776.0

c119

c119

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
513.956935060628, 579.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.0, 777.0

c120

c120

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
856.0, 1329.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
985.0, 1336.1692742632486

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.0, 779.0

c123

c123

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
289.2705042299956, 516.3376291348226

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.0, 446.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.4178657701922, 516.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
211.0, 568.0

c127

c127

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
331.18672362344194, 1177.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
167.0, 771.9652488049375

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.9414910983455, 612.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
277.8262807353909, 679.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.0, 766.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.0, 844.0

c132

c132

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
210.0, 568.0

c133

c133

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
305.0, 1129.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.0, 844.0

c135

c135

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
568.0, 1322.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 1337.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.0, 1338.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.4696877617359, 1081.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1200.0, 579.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
641.2871477742414, 1082.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
709.1057411452476, 1083.0

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
836.9919324320838, 1376.3591879744756

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.4, 1351.8

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.012093928822, 688.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
165.0, 623.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
186.0, 672.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
169.0, 682.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
184.0, 747.0

c148

c148

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
657.0, 1200.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.2063309876478, 972.0740528189224

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
181.0, 751.0

c150

c150

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
396.0, 1177.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.5214432661302, 676.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
662.1825801675245, 682.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
799.0, 1209.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
184.0, 745.0

c155

c155

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
534.3766017829493, 681.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
520.0, 1317.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
182.0, 751.0

c158

c158

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
493.0, 1133.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 927.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.40522495786104, 677.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
184.0, 750.0

c161

c161

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
176.0, 751.0

c162

c162

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
295.32332041740193, 677.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.0, 1311.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
414.0, 1253.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
180.0, 751.0

c166

c166

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
423.15026893832425, 678.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
888.7839466425096, 690.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
889.0, 1086.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 938.7879148012603

c17

c17

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
184.0, 743.0

c170

c170

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
243.02317597941288, 1057.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 751.0

c172

c172

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
280.28262614527114, 673.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
216.0, 568.0

c174

c174

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
774.0, 1309.5058324471802

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.0, 677.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.6564023547028, 659.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
777.0, 692.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.1778842533583, 783.0

c179

c179

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
716.0, 928.8996247238159

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.5655472379027, 1085.0

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1145.1146094037645, 1299.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 1447.6132233653639

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.7414442211777, 1453.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.339146548305, 690.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.8909272270704, 1262.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
237.0, 1251.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.87379148345155, 1079.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
243.66361306142267, 676.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1096.0, 1458.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.0, 607.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.0, 1485.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1099.1085797567785, 1477.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.0588235294117, 1433.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.3273865707608, 1086.0

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
732.5461526917569, 690.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1092.0, 1468.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1177.420470664982, 1604.9889426346601

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1104.0866716156727, 1597.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 1355.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
317.0, 685.0

c199

c199

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
696.0, 645.26575853755

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1119.0, 668.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.56365905269206, 1107.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.94236490407974, 1012.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
163.54274768265273, 975.5851456296082

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
164.0, 691.9869109946261

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 418.8003034806065

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
569.2203172225662, 418.68571346272915

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.8318433579008, 383.631634032896

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.6348020759259, 625.3895182069692

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
964.2044960296895, 577.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.8874122257146, 578.0698344970132

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 584.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 682.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.0, 678.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
860.0, 747.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.02711014499, 801.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.1647039824837, 690.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
665.6568542494924, 638.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.0, 1054.1639519239586

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 1069.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
821.0, 1052.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.2409175147444, 968.0050922643001

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.8102651883261, 965.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.7889304845424, 847.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
688.0, 881.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.0, 867.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 953.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.1554175279994, 913.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.3902826712724, 756.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.8868467733586, 990.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0, 1013.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.0, 959.9452867105489

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
323.0, 622.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.1192848634243, 652.3668216987254

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.0, 645.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.9913993818893, 636.3708583545488

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
413.71356238039726, 559.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 579.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
423.0, 937.197769023179

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 829.2975823717737

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
484.1129068832854, 940.6614963702988

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 941.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 674.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.9652896662093, 737.7444195949728

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.02316458331507, 692.8308170454446

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 748.2245290668825

c55

c55

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
661.0, 545.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
639.0, 608.600734457087

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 592.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.0887857024705, 440.70798021359997

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.8089875327071, 825.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.6879186258208, 448.09924335470504

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.2065767803004, 441.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.8736640378243, 482.41612662550796

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.2814378793594, 486.3137082564749

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.0, 445.62507945019456

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 476.08888340242845

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.0, 519.0

c66

c66

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
478.0, 1096.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.0, 1107.8421905149607

c68

c68

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
311.0, 1108.1836695489358

c69

c69

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 737.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 1436.8976891728457

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
177.0, 1413.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 1426.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
170.0, 1420.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.9711254108328, 1512.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
282.0, 1569.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.0, 1389.9978036392063

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.8911938185626, 1382.0634280792215

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.97611301724703, 1388.2640481511228

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 559.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 684.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.27426503695096, 1384.9632245814687

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 1302.5298221281348

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 1224.6380645059696

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.3526867907002, 1081.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.0, 1214.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
395.0, 1573.7513807567655

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.5799382318976, 1577.5582291532655

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.9808551409287, 1557.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.9178268547516, 1574.1436861012419

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
421.0, 559.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.0, 724.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
381.9991637489226, 1249.416536712452

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 1220.228478191191

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
547.201229712711, 1072.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.8446454055274, 1203.5689290811056

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.0, 399.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 420.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.0, 428.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.0, 517.1159660434203

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 508.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 423.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back