1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18022390.csml convertedTime:2009.07.01.11:10

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Nuclear receptors in macrophages: a link between metabolism and inflammation.
Authors Szanto A, Roszer T.
Affiliation University of Debrecen, Medical and Health Science Center, Research Center forMolecular Medicine, Life Science Building, Department of Biochemistry andMolecular Biology, Debrecen, Egyetem ter 1 H-4032, Hungary. szantoa@dote.hu
Abstract Subclinical inflammation is a candidate etiological factor in the pathogenesisof metabolic syndrome and in the progression of atherosclerosis. A central rolefor activated macrophages has been elucidated recently as important regulatorsof the inflammatory process in atherosclerosis. Macrophage differentiation andfunction can be modulated by a class of transcription factors termed nuclearreceptors. These are activated by intermediary products of basic metabolicprocesses. In this review the contribution of peroxisome proliferator-activatedreceptors and liver X receptors to macrophage functions in inflammation andlipid metabolism will be discussed in light of their roles in macrophages duringatherosclerosis. In the past decade much effort has been made to understand themechanisms how lipids are handled by macrophages and how inflammation couldpromote the atherogenic process. Here, we also provide an overview of these twofields.
PMID 18022390
Model Abstract

Entity

G010254:TGF-beta1 G010262:IL-6 G010279:MMP-9 G010329:TNF-alpha G010389:IL-1beta G010815:MCP1 G011208:CCR2 G011345:IL10 G011362:CD36 G011933:PTEN G013072:ABCA1 G013104:CYP27 G013114:ABCG1 G013426:Abcg5 G024648:AIM G025824:CD1D G029944:OLR1 MO000000084:M-CSFR MO000000090:GM-CSFR MO000000099:GM-CSF MO000000100:M-CSF MO000000290:LDL MO000008272:ROS MO000016932:CD154 MO000017053:IL-4 MO000017157:CXCR4 MO000017280:MCP-1 MO000017464:RXR MO000017541:PTEN MO000017886:RA MO000019821:CXCR2 MO000019907:CCR2 MO000021443:eicosanoid MO000021832:prostaglandins MO000033520:leukotrienes MO000033599:PPAR MO000033712:AEBP1 MO000056002:LXR MO000060632:MIF MO000062065:Abcg1 MO000107436:oxLDL e1: e10: e11:LXR: RXR e12:CD36 e13:oxLDL: CD36 e14:oxLDL: CD36: PPAR-gamma: RXR e15:LXR-alpha e16:oxysterol e17:oxysterol: LXR: RXR e18:ABCG8 e19:cholesterol e2: e20:27-hydroxycholesterol e21:CYP27 e22:27-hydroxycholesterol: LXR: RXR e23:PPARgamma e24:HDL e25:PPAR-beta: PPAR-theta e26:VLDL e27:VLDL: PPAR-beta: PPAR-theta e28:M-CSF: M-CSFR e29:SR-A e3: e30:GM-CSF: GM-CSFR e31:MIF: CXCR2 e32:MIF: CXCR4 e33:LDL: SR-B1 e34:HDL: SR-B1 e35:SR-B1 e36:SR e37:oxLDL e38:oxLDL: SR e39:ROS e4: e40:MMP e41:MMP e42:CD40 ligand e43:CD40 ligand: CD154 e44:IL-4 ligand e45:IL-4 ligand : IL-4 e46:IL-12 e47:retinoic acid e48:eicosanoid: PPAR e49:prostaglandins: PPAR e5:PPAR-gamma e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:PPAR-gamma: RXR e60: e61: e62: e63:leukotrienes: PPAR e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p6 p7 p8 p9
Model Detail
699.0, 1099.0
28.0, 28.0

TGF-beta1

--

G010254

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p43

--

true true true true

csml-variable:Double

m93240

10

false

infinite

0

unit false false false
TRANSFACG010254

--

Go back
618.0, 770.0
29.0, 29.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
560.0, 1020.0
26.0, 26.0

MMP-9

--

G010279

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p44

--

true true true true

csml-variable:Double

m93262

10

false

infinite

0

unit false false false
TRANSFACG010279

--

Go back
615.0, 959.0
27.0, 27.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p42

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
570.0, 822.0
30.0, 30.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p41

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
384.0, 852.0
25.0, 25.0

MCP1

--

G010815

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p26

true true true true

csml-variable:Double

m93710

10

false

infinite

0

unit false false false
TRANSFACG010815

--

Go back
380.0, 912.0
26.0, 26.0

CCR2

--

G011208

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m94093

10

false

infinite

0

unit false false false
TRANSFACG011208

--

Go back
739.0, 1059.0
28.0, 28.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p45

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
457.0, 957.0
23.0, 23.0

CD36

--

G011362

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m94247

10

false

infinite

0

unit false false false
TRANSFACG011362

--

Go back
664.0, 1108.0
26.0, 26.0

PTEN

--

G011933

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p50

p51

true true true true

csml-variable:Double

m94744

10

false

infinite

0

unit false false false
TRANSFACG011933

--

Go back
708.0, 768.0
26.0, 26.0

ABCA1

--

G013072

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p8

--

true true true true

csml-variable:Double

m95583

10

false

infinite

0

unit false false false
TRANSFACG013072

--

Go back
606.0, 726.0
30.0, 30.0

CYP27

--

G013104

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p14

p15

true true true true

csml-variable:Double

m95607

10

false

infinite

0

unit false false false
TRANSFACG013104

--

Go back
662.0, 798.0
30.0, 30.0

ABCG1

--

G013114

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p9

p17

true true true true

csml-variable:Double

m95617

10

false

infinite

0

unit false false false
TRANSFACG013114

--

Go back
682.0, 950.0
29.0, 29.0

Abcg5

--

G013426

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p10

--

true true true true

csml-variable:Double

m95887

10

false

infinite

0

unit false false false
TRANSFACG013426

--

Go back
722.0, 1010.0
29.0, 29.0

AIM

--

G024648

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p18

--

true true true true

csml-variable:Double

m103353

10

false

infinite

0

unit false false false
TRANSFACG024648

--

Go back
623.0, 1115.0
28.0, 28.0

CD1D

--

G025824

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m104528

10

false

infinite

0

unit false false false
TRANSFACG025824

--

Go back
495.0, 1095.0
28.5, 28.5

OLR1

--

G029944

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p35

--

true true true true

csml-variable:Double

m108642

10

false

infinite

0

unit false false false
TRANSFACG029944

--

Go back
152.0, 1049.0
30.0, 30.0

M-CSFR

--

MO000000084

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000084

--

Go back
247.0, 1195.0
28.0, 28.0

GM-CSFR

--

MO000000090

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000090

--

Go back
302.0, 1218.0
30.0, 30.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
77.0, 1018.0
28.0, 28.0

M-CSF

--

MO000000100

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR008001
TRANSPATHMO000000100

--

Go back
62.0, 467.0
34.0, 34.0

LDL

--

MO000000290

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m290118

10

false

infinite

0

unit false false false
TRANSPATHMO000000290

--

Go back
390.0, 1222.0
30.0, 30.0

ROS

--

MO000008272

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

--

true true true true

csml-variable:Double

m1063

10

false

infinite

0

unit false false false
TRANSPATHMO000008272

--

Go back
720.0, 1356.0
33.0, 33.0

CD154

--

MO000016932

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m1845

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000016932

--

Go back
1035.0, 1007.0
28.0, 28.0

IL-4

--

MO000017053

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m1947

10

false

infinite

0

unit false false false
InterProIPR001325
TRANSPATHMO000017053

--

Go back
148.0, 361.0
32.0, 32.0

CXCR4

--

MO000017157

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m2033

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017157

--

Go back
214.0, 850.0
30.0, 30.0

MCP-1

--

MO000017280

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m2133

10

false

infinite

0

unit false false false
InterProIPR008097
TRANSPATHMO000017280

--

Go back
656.0, 704.0
26.5, 26.5

RXR

--

MO000017464

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m2283

10

false

infinite

0

unit false false false
TRANSPATHMO000017464

--

Go back
817.0, 1217.0
32.0, 32.0

PTEN

--

MO000017541

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

p43

true true true true

csml-variable:Double

m2334

10

false

infinite

0

unit false false false
InterProIPR000387
TRANSPATHMO000017541

--

Go back
716.0, 1228.0
26.0, 26.0

RA

--

MO000017886

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p49

true true true true

csml-variable:Double

m348799

10

false

infinite

0

unit false false false
TRANSPATHMO000017886

--

Go back
142.0, 299.0
36.0, 36.0

CXCR2

--

MO000019821

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m4350

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000019821

--

Go back
208.0, 892.0
34.0, 34.0

CCR2

--

MO000019907

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m4436

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000019907

--

Go back
275.0, 687.0
28.0, 28.0

eicosanoid

--

MO000021443

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m5792

10

false

infinite

0

unit false false false
TRANSPATHMO000021443

--

Go back
243.0, 731.0
26.0, 26.0

prostaglandins

--

MO000021832

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m6166

10

false

infinite

0

unit false false false
EnsemblENSG00000035862
TRANSPATHMO000021832

--

Go back
257.0, 841.0
24.0, 24.0

leukotrienes

--

MO000033520

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m12196

10

false

infinite

0

unit false false false
TRANSPATHMO000033520

--

Go back
384.0, 756.0
26.0, 26.0

PPAR

--

MO000033599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52 p53 p54

true true true true

csml-variable:Double

m12274

10

false

infinite

0

unit false false false
TRANSPATHMO000033599

--

Go back
232.0, 944.0
34.0, 34.0

AEBP1

--

MO000033712

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p23 p39

true true true true

csml-variable:Double

m12375

10

false

infinite

0

unit false false false
InterProIPR000421
TRANSPATHMO000033712

--

Go back
707.0, 723.0
28.0, 28.0

LXR

--

MO000056002

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m31326

10

false

infinite

0

unit false false false
TRANSPATHMO000056002

--

Go back
71.0, 324.0
33.0, 33.0

MIF

--

MO000060632

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p25

true true true true

csml-variable:Double

m35533

10

false

infinite

0

unit false false false
TRANSPATHMO000060632

--

Go back
962.0, 978.0
30.0, 30.0

Abcg1

--

MO000062065

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m36957

10

false

infinite

0

unit false false false
TRANSPATHMO000062065

--

Go back
336.0, 600.0
26.0, 26.0

oxLDL

--

MO000107436

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m341431

10

false

infinite

0

unit false false false
TRANSPATHMO000107436

--

Go back
125.83210304806425, 24.75833808450841
953.0937952194098, 1383.8921906585833

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
135.01509540326288, 45.91048941510371
923.8397501264645, 1299.5827589451033

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
768.75, 758.0
24.5, 30.0

LXR: RXR

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p7 p13

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
419.0, 735.0
20.0, 20.0

CD36

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
Affymetrix109884_f_at
EnsemblENSMUSG00000002944
InterProIPR005429
MGDMGI:107899
ProteomeHumanPSD/Cd36
RefSeqNM_007643
TRANSPATHMO000031132
UnigeneMm.18628
UniProtQ08857

--

Go back
456.25, 701.0
25.04264415698312, 48.469633852225385

oxLDL: CD36

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
502.25, 688.0
21.956917342688005, 42.497259372944534

oxLDL: CD36: PPAR-gamma: RXR

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p5 p6 p14 p17 p21 p26 p27 p35 p44 p47 p50

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
324.0, 924.0
26.0, 26.0

LXR-alpha

--

e15

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p6

--

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
Affymetrix1373641_at
EnsemblENSRNOG00000013172
MGDNr1h3
ProteomeHumanPSD/Nr1h3
RefSeqNM_031627
TRANSFACG002452
UnigeneRn.11209

--

Go back
854.0, 736.5
30.0, 17.0

oxysterol

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
833.25, 849.0
24.342578381933787, 47.114667836000876

oxysterol: LXR: RXR

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8 p9 p10 p11 p18 p40 p41 p42 p44 p45 p46

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
638.0, 851.0
38.667820069204154, 20.622837370242216

ABCG8

--

e18

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p11

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
796.0, 559.5
30.0, 25.0

cholesterol

--

e19

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
125.83210304806425, 24.75833808450841
953.0937952194098, 1383.8921906585833

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
800.0, 663.5
30.0, 17.0

27-hydroxycholesterol

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
745.0, 614.0
28.0, 28.0

CYP27

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p12

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000066070

--

Go back
853.25, 926.0
23.75126068844552, 45.970181977636486

27-hydroxycholesterol: LXR: RXR

--

e22

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p13

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
386.0, 990.0
30.0, 30.0

PPARgamma

--

e23

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p23 p39

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSFACG002769

--

Go back
60.0, 636.75
30.0, 22.5

HDL

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p28

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
299.0, 1003.0
28.0, 28.0

PPAR-beta: PPAR-theta

--

e25

cso30:c:Complex

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
Affymetrix117189_at
EnsemblENSMUSG00000002250
InterProIPR003074
MGDPpard
ProteomeHumanPSD/Ppard
RefSeqNM_011145
TRANSFACT04781
TRANSPATHMO000028591
UnigeneMm.1303
UniProtP35396

--

Go back
218.0, 1053.75
30.0, 22.5

VLDL

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
326.25, 1045.0
20.71311115983337, 40.089892567419426

VLDL: PPAR-beta: PPAR-theta

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
156.25, 1083.0
21.793795220346414, 42.18153913615435

M-CSF: M-CSFR

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p21

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
447.0, 1087.0
27.0, 27.0

SR-A

--

e29

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
Affymetrix225500_3p_x_at
EnsemblENSG00000126461
HGNCSCAF1
ProteomeHumanPSD/SR-A1
RefSeqNM_021228
TRANSFACG042947
UnigeneHs.103521

--

Go back
144.89397895245236, 43.82021398889651
914.9700434106333, 1345.7684388498078

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
358.25, 1173.0
21.093729445297086, 40.82657311992984

GM-CSF: GM-CSFR

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p23

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
146.75, 228.0
34.91076487252124, 42.74787535410765

MIF: CXCR2

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
151.75, 421.0
32.19988335277454, 39.428428595234124

MIF: CXCR4

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
149.75, 498.0
35.2210464922513, 43.127812031328105

LDL: SR-B1

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
151.75, 589.0
31.358856857190467, 38.39860023329445

HDL: SR-B1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
63.0, 544.0
32.0, 32.0

SR-B1

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p29

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000101490

--

Go back
408.5, 1358.0
25.337434094903333, 38.980667838312826

SR

--

e36

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p30

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
380.0, 1424.0
26.0, 26.0

oxLDL

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
TRANSPATHMO000107436

--

Go back
469.375, 1350.5
23.25, 45.0

oxLDL: SR

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31 p32 p33 p34

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
430.0, 1122.0
30.0, 30.0

ROS

--

e39

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p31

p32

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSFACG012563

--

Go back
180.15844937557063, 77.17849682157589
844.4411025643969, 1279.0518731844484

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
509.5, 1158.0
39.965397923875436, 21.314878892733564

MMP

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p34 p37

p33

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
562.5, 1234.125
36.644194002817464, 22.597252968404106

MMP

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
726.5, 1429.375
37.267135325131804, 24.22363796133568

CD40 ligand

--

e42

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
661.375, 1350.5
23.25, 45.0

CD40 ligand: CD154

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p36

p37

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1145.5, 1008.375
39.130052724077316, 25.43453427065026

IL-4 ligand

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p38

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1037.375, 1070.5
23.25, 45.0

IL-4 ligand : IL-4

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p38

p39

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
782.0, 1050.0
29.0, 29.0

IL-12

--

e46

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p46

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
571.5, 1094.0
42.24913494809689, 22.53287197231834

retinoic acid

--

e47

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47

p48

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
365.25, 782.0
15.5, 30.0

eicosanoid: PPAR

--

e48

cso30:c:Complex

cso30:i:CC_NuclearPore

--

p52

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
341.25, 802.0
15.5, 30.0

prostaglandins: PPAR

--

e49

cso30:c:Complex

cso30:i:CC_NuclearOuterMembrane

--

p53

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
611.0, 691.0
27.0, 27.0

PPAR-gamma

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000018994

--

Go back
298.4415104735656, 704.7859749093554
568.2995748390099, 515.3852755057702

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
359.82209770012514, 716.999856686503
332.30179981275455, 499.5109857057976

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
305.8495123802195, 711.6648338226767
553.4835710257028, 501.62755767912694

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
306.9077983668842, 712.7231198093419
551.3669990523731, 499.5109857057976

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
298.4415104735656, 704.7859749093554
568.2995748390099, 515.3852755057702

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
298.4415104735656, 704.7859749093554
568.2995748390099, 515.3852755057702

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
306.9077983668842, 712.7231198093419
551.3669990523731, 499.5109857057976

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
713.2896172461762, 916.443172242321
35.504234911612244, 32.14067581472273

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
620.1604504196723, 1064.6032103753955
100.5371687331582, 91.012594853175

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
298.4415104735656, 704.7859749093554
568.2995748390099, 515.3852755057702

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
548.5, 685.0
25.42676220629895, 31.13481086485586

PPAR-gamma: RXR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
432.38652266150814, 933.8189326805286
17.997212506640835, 8.665324540234504

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
431.785544793333, 907.9768843490012
61.600231487943034, 110.88041667829755

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
457.6275931248608, 980.0942285300086
9.61564589080085, 9.61564589080087

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
324.25, 824.1979828984872
16.947708835781626, 32.80201710151283

leukotrienes: PPAR

--

e63

cso30:c:Complex

cso30:i:CC_NuclearOuterMembrane

--

p54

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
138.3543653506079, 30.327229660827015
934.6880780053893, 1324.4288632991509

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
141.69363529795282, 53.70211929224189
896.657410759075, 1301.9465604221787

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
150.59835515753946, 77.07700892365659
892.5636778315313, 1284.8718575205314

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
606.0, 586.0
30.0, 30.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000017464

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c1 : 1

m5*m2283*0.1

nodelay

--

true

0

false

PMID: 18022390 Here, we are focusing on PPAR-gamma and liver X receptor (LXR) since they have been shown to play a substantial role in lesion macrophages during atherosclerosis. Both of them form heterodimer with a common partner, retinoid X receptor (RXR).

Go back
737.0, 933.0
24.0, 24.0

p10

p10

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G013426

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18022390, 10968783, 10858438 , 10799558 Several studies reported that LXRs mediate cholesterol efflux by inducing cholesterol transporters ABCA1, ABCG1 and later ABCG5 and ABCG8.

Go back
720.0, 852.0
25.0, 25.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18022390, 10968783, 10858438 , 10799558 Several studies reported that LXRs mediate cholesterol efflux by inducing cholesterol transporters ABCA1, ABCG1 and later ABCG5 and ABCG8.

Go back
800.0, 613.0
30.0, 30.0

p12

p12

cso30:i:ME_MetabolicReaction

cso30:i:CC_Cytosol

--

e19 e21

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m19*m21*0.1

nodelay

--

true

0

false

PMID: 18022390, 2722778, 9660774 One of these, 27-hydroxycholesterol is produced by a p450 enzyme CYP27, which is a mitochondrial enzyme involved in alternative bile acid synthesis.

Go back
766.0, 702.0
30.0, 30.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e11

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m20*m11*0.1

nodelay

--

true

0

false

PMID: 18022390 A number of oxysterols were identified as potential endogenous ligands for LXR. One of these, 27-hydroxycholesterol is produced by a p450 enzyme CYP27.

Go back
557.0, 773.0
23.0, 23.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G013104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18022390, 15340076 We found that retinoid receptors and PPAR-gamma induce the expression of CYP27 resulting in increased production 27-hydroxycholesterol in macrophages which activates LXR and enhances cholesterol efflux from macrophages through ABC transporters. PMID: 18022390, 15340076 CYP27 can be induced by retinoids and PPAR-¦Ã only in human macrophages

Go back
683.0, 616.0
23.0, 23.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G013104

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c37 : 1

m95607*0.1

nodelay

--

true

0

false

PMID: 18022390, 15340076 We found that retinoid receptors and PPAR-gamma induce the expression of CYP27 resulting in increased production 27-hydroxycholesterol in macrophages which activates LXR and enhances cholesterol efflux from macrophages through ABC transporters.

Go back
898.0, 978.0
30.0, 30.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G013114 e14

MO000062065

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1
stoichiometry:c43 : 1

m95617*m14*0.1

nodelay

--

true

0

false

PMID: 18022390 PPAR-gamma can both directly and indirectly (through LXR) induce transcription of ABCG1.

Go back
772.0, 948.0
25.0, 25.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G024648

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18022390, 15479645 AIM is regulated by LXR only in mice.

Go back
274.0, 1050.0
30.0, 30.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 e25

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1

m26*m25*0.1

nodelay

--

true

0

false

PMID: 18022390, 12540828 PPAR-beta/theta functions as a sensor for VLDL and promotes VLDL-derived fatty acid catabolism.

Go back
712.0, 660.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017464 MO000056002

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m2283*m31326*0.1

nodelay

--

true

0

false

PMID: 18022390 Here, we are focusing on PPAR-gamma and liver X receptor (LXR) since they have been shown to play a substantial role in lesion macrophages during atherosclerosis. Both of them form heterodimer with a common partner, retinoid X receptor (RXR).

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76.0, 1089.0
30.0, 30.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000100 MO000000084

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m89*m76*0.1

nodelay

--

true

0

false

PMID: 18022390 Development of macrophages is driven by monocyte colony-stimulating factor (M-CSF). It also augments SR-A, cytokine and growth factor expression and serves as a survival stimulus.

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397.0, 1101.0
23.0, 23.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28 e14

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c91 : 1
stoichiometry:c54 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 18022390 Development of macrophages is driven by monocyte colony-stimulating factor (M-CSF). It also augments SR-A, cytokine and growth factor expression and serves as a survival stimulus. PMID: 18022390, 9422508 As detailed above, PPAR-gamma was reported to upregulate expression of scavenger receptor CD36 and downregulate SR-A in macrophages.

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303.0, 1123.0
27.0, 27.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000090 MO000000099

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m81*m88*0.1

nodelay

--

true

0

false

PMID: 18022390, 16873730 At the same time GM-CSF deficiency reduces PPAR-gamma expression and aggravates atherosclerosis in ApoE knockout mice.

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356.0, 1056.0
26.0, 26.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30 MO000033712

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c138 : 1
stoichiometry:c58 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18022390, 16873730 At the same time GM-CSF deficiency reduces PPAR-gamma expression and aggravates atherosclerosis in ApoE knockout mice. PMID: 18022390, 16461908 AEBP1 overexpression in macrophages is accompanied by decreased expression of PPAR-gamma, LXR-greek small letter alpha and their target genes with concomitant elevation of pro-inflammatory cytokines.

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73.0, 426.0
30.0, 30.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017157 MO000060632

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c65 : 1

m2033*m35533*0.1

nodelay

--

true

0

false

PMID: 18022390, 17435771 MIF has been reported recently as a ligand for chemokine receptors CXCR2 and CXCR4 that control leukocyte recruitment during atherogenesis.

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73.0, 234.0
30.0, 30.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019821 MO000060632

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c64 : 1

m4350*m35533*0.1

nodelay

--

true

0

false

PMID: 18022390, 17435771 MIF has been reported recently as a ligand for chemokine receptors CXCR2 and CXCR4 that control leukocyte recruitment during atherogenesis.

Go back
269.0, 869.0
23.0, 23.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010815 e14

MO000017280

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c66 : 1
stoichiometry:c68 : 1

m93710*m14*0.1

nodelay

--

true

0

false

PMID: 18022390, 15947238, 10995790, 15896316 PPAR-gamma represses transcription of MCP-1 and its receptor CCR2 in macrophages regulating recruitment of these cells to inflammatory loci in the colon.

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260.0, 896.0
25.0, 25.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011208 e14

MO000019907

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c69 : 1

m94093*m14*0.1

nodelay

--

true

0

false

PMID: 18022390, 15947238, 10995790, 15896316 PPAR-gamma represses transcription of MCP-1 and its receptor CCR2 in macrophages regulating recruitment of these cells to inflammatory loci in the colon.

Go back
90.0, 595.0
26.0, 26.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 e35

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m24*m35*0.1

nodelay

--

true

0

false

PMID: 18022390, 11861414, 14581413, 15331403 SR-B1 is expressed in the liver and also in macrophages. It binds HDL, LDL, modified LDL and if knocked out, atherosclerosis is increased in ApoE-deficient or LDLR-deficient mice.

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102.0, 507.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000290 e35

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c77 : 1

m290118*m35*0.1

nodelay

--

true

0

false

Go back
414.0, 598.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000107436 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m341431*m12*0.1

nodelay

--

true

0

false

PMID: 18022390, 9568716 Oxidized but not native LDL promotes its own uptake via scavenger receptor CD36 by PPAR-gamma.

Go back
442.0, 1422.0
30.0, 30.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e37 e36

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m37*m36*0.1

nodelay

--

true

0

false

PMID: 18022390 As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).

Go back
477.0, 1125.0
23.0, 23.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c81 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 18022390 As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).

Go back
440.0, 1220.0
25.0, 25.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e39 e38

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c82 : 1

m39*m38*0.1

nodelay

--

true

0

false

PMID: 18022390 As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).

Go back
491.0, 1231.0
27.0, 27.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e38

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c87 : 1

m40*m38*0.1

nodelay

--

true

0

false

PMID: 18022390 As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).

Go back
569.0, 1165.0
23.0, 23.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c86 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 18022390 As a result macrophages take up oxLDL via scavenger receptors (SR) and start to produce metalloproteinases (MMPs), cytokines and reactive oxygen species (ROS).

Go back
488.0, 984.0
26.0, 26.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G029944

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m14*0.1

nodelay

--

true

0

false

PMID; 18022390, 16007265 PPAR-gamma was also reported to induce oxLDL receptor-1 in adipocytes resulting in increased uptake of the lipoprotein.

Go back
658.0, 1426.0
30.0, 30.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016932 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m1845*m42*0.1

nodelay

--

true

0

false

PMID: 18022390, 9244201, 9050882, 9671306 Binding of CD40 ligand to its receptor CD154 induces inflammatory response along with expression of pro-inflammatory cytokines, MMPs, adhesion molecules and tissue factor while inhibition of CD40 ligation reduces plaque size.

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539.0, 1115.0
27.0, 27.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 18022390, 9244201, 9050882, 9671306 Binding of CD40 ligand to its receptor CD154 induces inflammatory response along with expression of pro-inflammatory cytokines, MMPs, adhesion molecules and tissue factor while inhibition of CD40 ligation reduces plaque size.

Go back
1082.0, 1006.0
30.0, 30.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e44 MO000017053

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m44*m1947*0.1

nodelay

--

true

0

false

PMID: 18022390, 10432118 IL-4 induces expression of PPAR-gamma.

Go back
457.0, 1025.0
23.0, 23.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45 MO000033712

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c10 : 1
stoichiometry:c102 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18022390, 10432118 IL-4 induces expression of PPAR-gamma. PMID: 18022390, 16461908 AEBP1 overexpression in macrophages is accompanied by decreased expression of PPAR-gamma, LXR-greek small letter alpha and their target genes with concomitant elevation of pro-inflammatory cytokines.

Go back
502.0, 590.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e6

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1

m13*m6*0.1

nodelay

--

true

0

false

PMID: 18022390, 9568716 Oxidized but not native LDL promotes its own uptake via scavenger receptor CD36 by PPAR-gamma. PMID: 18022390, 9568715 Two components from oxLDL, 9-hydroxy octadecadienoic acid (9-HODE) and 13-HODE were identified as endogenous activators and bona fide ligands for PPAR-gamma.

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617.0, 821.0
23.0, 23.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c107 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18022390, 12524534 It was shown recently, that activation of LXR inhibits secretion of pro-inflammatory molecules like inducible nitric oxide synthase, IL-6, IL-1beta, TNF-alpha.

Go back
617.0, 873.0
23.0, 23.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c108 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18022390, 12524534 It was shown recently, that activation of LXR inhibits secretion of pro-inflammatory molecules like inducible nitric oxide synthase, IL-6, IL-1beta, TNF-alpha.

Go back
618.0, 910.0
21.0, 21.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c109 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18022390, 12524534 It was shown recently, that activation of LXR inhibits secretion of pro-inflammatory molecules like inducible nitric oxide synthase, IL-6, IL-1beta, TNF-alpha.

Go back
752.0, 1096.0
25.0, 25.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000017541

G010254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c110 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18022390, 16611854 PPAR-gamma can repress TGF-beta1 gene through induction of phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

Go back
546.0, 978.0
22.0, 22.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14 e17

G010279

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18022390, 12588772 It inhibits expression of MMP-9. PMID: 18022390, 12531895 Interestingly, LXR can also repress MMP-9 expression.

Go back
778.0, 1010.0
21.0, 21.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c115 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18022390, 17255360 LXR also alters DC phenotype by decreasing IL-12, increasing IL-10 secretion and blocking its T-cell stimulatory ability.

Go back
814.0, 1010.0
21.0, 21.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c117 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18022390, 17255360 LXR also alters DC phenotype by decreasing IL-12, increasing IL-10 secretion and blocking its T-cell stimulatory ability.

Go back
528.0, 1044.0
25.0, 25.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18022390, 15345223, 16982809 PPAR-gamma via induction of retinoic acid synthesis induces CD1d expression in DCs resulting in NKT cell proliferation and possibly altered lipid presentation by CD1 molecules.

Go back
658.0, 1226.0
30.0, 30.0

p48

p48

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e47

MO000017886

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18022390, 15345223, 16982809 PPAR-gamma via induction of retinoic acid synthesis induces CD1d expression in DCs resulting in NKT cell proliferation and possibly altered lipid presentation by CD1 molecules.

Go back
657.0, 1157.0
23.0, 23.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000017886

G025824

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c123 : 1

m348799*0.1

nodelay

--

true

0

false

PMID: 18022390, 15345223, 16982809 PPAR-gamma via induction of retinoic acid synthesis induces CD1d expression in DCs resulting in NKT cell proliferation and possibly altered lipid presentation by CD1 molecules.

Go back
465.0, 909.0
23.0, 23.0

p5

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G011362

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18022390 the consequence of oxLDL internalization is the activation of PPAR-gamma that enhances further expression of CD36. PMID: 18022390 There is no change in the mRNA level of CD36 when PPAR-gamma-deficient macrophages are treated with synthetic agonists such as thiazolidinediones (TZDs).

Go back
596.0, 1056.0
25.0, 25.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

G011933

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18022390, 16611854 PPAR-gamma can repress TGF-beta1 gene through induction of phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

Go back
763.0, 1219.0
27.0, 27.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011933

MO000017541

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m94744*0.1

nodelay

--

true

0

false

PMID: 18022390, 16611854 PPAR-gamma can repress TGF-beta1 gene through induction of phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

Go back
334.0, 698.0
25.0, 25.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033599 MO000021443

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c132 : 1
stoichiometry:c135 : 1

m12274*m5792*0.1

nodelay

--

true

0

false

PMID: 18022390 PPARs and LXRs are activated by fatty acids, oxLDL, arachidonic acid metabolites like eicosanoids, prostaglandins, leukotriens and oxidized cholesterol, respectively.

Go back
297.5, 741.5
23.0, 23.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033599 MO000021832

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c133 : 1
stoichiometry:c136 : 1

m12274*m6166*0.1

nodelay

--

true

0

false

PMID: 18022390 PPARs and LXRs are activated by fatty acids, oxLDL, arachidonic acid metabolites like eicosanoids, prostaglandins, leukotriens and oxidized cholesterol, respectively.

Go back
217.5, 769.5
23.0, 23.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000033599 MO000033520

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c134 : 1
stoichiometry:c137 : 1

m12274*m12196*0.1

nodelay

--

true

0

false

PMID: 18022390 PPARs and LXRs are activated by fatty acids, oxLDL, arachidonic acid metabolites like eicosanoids, prostaglandins, leukotriens and oxidized cholesterol, respectively.

Go back
400.0, 952.0
25.0, 25.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14 MO000033712

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c41 : 1
stoichiometry:c16 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18022390, 11172721 As detailed above, PPAR-gamma enhances uptake of its own ligand via oxLDL but it can also induce cholesterol efflux from macrophages via several mechanisms. An important one is the induction of another nuclear receptor, LXR-alpha, which in turn activates expression of a set of genes involved in cholesterol efflux and transport. PMID: 18022390, 16461908 AEBP1 overexpression in macrophages is accompanied by decreased expression of PPAR-gamma, LXR-greek small letter alpha and their target genes with concomitant elevation of pro-inflammatory cytokines.

Go back
854.0, 782.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m11*m16*0.1

nodelay

--

true

0

false

PMID: 18022390, 11504730, 9794827, 8878485 A number of oxysterols were identified as potential endogenous ligands for LXR.

Go back
748.0, 800.0
25.0, 25.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G013072

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c21 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18022390, 11035776 Among LXR target genes there are lipid transporters, such as ABCA1 and ABCG1, members of the ATP-binding cassette family of transporter proteins that are likely to be responsible for cholesterol efflux.

Go back
708.0, 812.0
25.0, 25.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G013114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c22 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18022390, 11035776 Among LXR target genes there are lipid transporters, such as ABCA1 and ABCG1, members of the ATP-binding cassette family of transporter proteins that are likely to be responsible for cholesterol efflux.

Go back
575.0866127295557, 616.0

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.0, 967.0

c10

c10

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1063.0, 1021.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1065.3599068047633, 1036.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.25848485227027, 1015.3636881022716

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
486.6419115308514, 1048.4592612859467

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
643.9321789623414, 835.73346343339

c104

c104

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
643.9946415151165, 874.0

c105

c105

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
642.9052213062357, 876.0

c106

c106

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
630.0, 806.9671456517416

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.367306591753, 857.9322862329901

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.0, 931.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
479.0, 627.4404159196479

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.974522228289, 1110.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.1214751973158, 1186.145770236779

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.0, 730.0

c112

c112

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
571.7090607992639, 878.0

c113

c113

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
561.0, 1000.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.4920113466981, 1031.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.8233735485547, 896.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
810.2719439311038, 1031.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.1119090269775, 896.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
515.0, 730.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.352465419694, 627.2636750760037

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.0, 1068.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.0, 1117.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
688.0, 1241.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.9425724154552, 1149.2905467105793

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.0, 730.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.0, 1078.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
790.0, 1233.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
689.0, 1134.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.905132594163, 1124.517167866147

c128

c128

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
362.28091686182944, 729.009319187599

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.2351924128152, 620.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.8587085313798, 756.49689686312

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
248.98051059275878, 770.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.0, 703.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
269.0, 746.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.92208991706048, 799.9726042969965

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 723.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 765.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
241.0, 788.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
266.0, 976.0

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
472.2639240088534, 932.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.322339138031, 730.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.52709929494983, 944.7097557461819

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.91898959187154, 730.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 776.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.0, 754.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
622.319744306791, 623.9936076697743

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.4680375842995, 812.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.2905467105794, 796.9425724154552

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.6358398242802, 819.3861999450876

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.5025370205917, 826.660151531424

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
740.4782686447068, 832.8417420849886

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.4, 882.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.9814695414523, 866.544191105099

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
718.4667648496245, 949.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.9913606886246, 862.3716911948197

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 585.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.1007091149047, 623.3746595165301

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 643.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
773.0, 628.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.8483457221029, 681.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 740.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 716.5964179097824

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 724.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 758.1675379317294

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 628.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 645.6916890366381

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.0, 688.9711576880163

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.0, 961.0

c41

c41

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
676.8203713597735, 828.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.0, 993.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.0, 730.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
798.4639807177581, 890.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.8275413614842, 973.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 1065.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.42469075791234, 1031.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.0, 1065.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
722.0, 692.9889426346601

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
91.0, 1046.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
113.09267876932364, 1072.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.0, 1104.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
178.0, 1104.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 1105.7354436625492

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
272.0, 1156.3148177390106

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.0, 1158.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
329.0, 1150.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.0, 1027.1554175279994

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.0, 1090.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
732.0, 685.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
108.80370958807373, 268.506083455352

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
109.11223932677521, 390.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
88.0, 272.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
88.0, 357.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
103.0, 249.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
103.0, 441.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.23313904891893, 721.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
299.9213087993047, 867.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
251.6193931775946, 872.4382058168303

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.0, 909.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
362.0, 613.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.936931020997, 912.0025597079155

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
292.94222193887924, 729.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
96.0, 499.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
83.0, 627.5923353935949

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
93.0, 537.897233121606

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
87.0, 576.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
116.0, 608.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
127.0, 520.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.0, 1437.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 1397.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
429.0, 636.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.0, 1403.4667648496245

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 1137.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.96029752167993, 1234.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.0, 1152.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.5546894146929, 1252.8474799027358

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.0, 1155.9952479948288

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.9114908229463, 1174.186723623442

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 1245.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
511.4859108504594, 1179.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
485.0, 1265.8542388047222

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 628.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.0, 1195.1289833923402

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
412.9922448940521, 730.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
502.31471681833983, 730.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.0, 1010.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.4975988310086, 1389.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
696.0, 1441.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 1404.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.9220899170605, 1142.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.2472083089206, 1138.3879155430902

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1120.0, 1021.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back