1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18029230.csml convertedTime:2009.07.01.11:10

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Signaling to NF-kappaB by Toll-like receptors.
Authors Kawai T, Akira S.
Affiliation Department of Host Defense and Exploratory Research for Advanced Technology,Japan Science and Technology Agency, Research Institute for Microbial Diseases,Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract Innate immunity is the first line of defense against invading pathogens. Afamily of Toll-like receptors (TLRs) acts as primary sensors that detect a widevariety of microbial components and elicit innate immune responses. All TLRsignaling pathways culminate in activation of the transcription factor nuclearfactor-kappaB (NF-kappaB), which controls the expression of an array ofinflammatory cytokine genes. NF-kappaB activation requires the phosphorylationand degradation of inhibitory kappaB (IkappaB) proteins, which is triggered bytwo kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta. In addition, severalTLRs activate alternative pathways involving the IKK-related kinases TBK1 [TRAFfamily member-associated NF-kappaB activator (TANK) binding kinase-1] and IKKi,which elicit antiviral innate immune responses. Here, we review recent progressin our understanding of the role of NF-kappaB in TLR signaling pathways anddiscuss potential implications for molecular medicine.
PMID 18029230
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha MO000000058:NF-kappaB MO000000062:ATF-2 MO000000065:RIP1{ub} MO000000077:MAPKs MO000000193:RelA-p65 MO000000194:RelB MO000000196:p52 MO000000199:p105 MO000000202:p100{p} MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000215:IkappaB MO000000248:IKK{active} MO000000289:TNF-alpha MO000007694:IRF-3 MO000013119:STAT1 MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016599:IKK-gamma MO000016608:IKK-i MO000016882:LPS MO000016899:FADD MO000016900:Caspase-8/10 MO000016963:TRAF3 MO000019326:TANK MO000019331:TBK1 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019422:TLR6 MO000022125:TAB2 MO000022136:Ubc13 MO000022185:flagellin MO000022224:dsRNA MO000022528:TIRAP MO000036852:AP1 MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041541:TAB3 MO000042007:TLR8 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 MO000042130:TLR11 MO000061425:ZBP1 e1: e10: e100:IRF7{p}:IRF7{p} e101:IFN-alpha e102:TLR1:TLR2:Triacyl lipopeptides e103:TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88 e104:TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4 e105:TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4{p} e106:TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4{p}:IRAK1 e107:TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4{p}:IRAK1{p} e108:IRAK-4{p}:IRAK1{p} e109:IRAK4{p}:IRAK1{p}:TRAF6 e11:TLR2:Lipoarabinomannan:TLR2 e110:LPS;TLR4:TIRAP:MyD88:IRAK-4 e111:LPS;TLR4:TIRAP:MyD88:IRAK-4{p} e112:LPS;TLR4:TIRAP:MyD88:IRAK-4{p}:IRAK1 e113:LPS;TLR4:TIRAP:MyD88:IRAK-4{p}:IRAK1{p} e114:cyclohexamide e115:TNF-alpha receptor e116:TNF-alpha:receptor e117:RIG-1 e118:Mda5 e119:IPS-1 e12:Hemagglutinin e120:RIG-1:IPS-1:RNA:FADD:Caspase 8/10,TRA:F3:NEMO e121:RIG-1:RNA:IPS-1 e122:Mda5:IPS-1:RNA:FADD:Caspase 8/10,TRA:F3:NEMO e123:RNA e124:RIG-1:RNA e125:Mda5:RNA e126:Mda5:RNA:IPS-1 e127:STAT1{p} e128:dsDNA e129:ZBP1:dsDNA e13:Hemagglutinin:TLR2 e130:ZBP1:dsDNA:TBK1:IKKi e131:IRF7{p} e132:ubiquitin e133:IKK-beta{p} e134:p50 e135:Ikk-alpha:IKK-alpha e136:p100 e137:p52:RelB e138:mRNA e139:TRAF6{ub}:TABs:TAK1 e14:tGPI-mutin e140:IKK-gamma{ub}:TABs:TAK1 e141:RIP1:TRAF6:TAK1:TRIF e15:tGPI-mutin:TLR2 e16:TLR2:TLR1 e17:Triacyl lipopeptide:TLR1:TLR2 e18:Tri-acyl Lipopeptide e19:TLR2:TLR6 e2: e20:Diacyl lipopeptide:TLR2:TLR6 e21:Di-acyl Lipopeptide e22:LPS:TLR4 e23:MPLA e24:MPLA:TLR4 e25:Envelope protein e26:Envelope protein:TLR4 e27:Flagellin:TLR5 e28:Lamina Propria e29:TLR5:Lamina Propria e3: e30:Uropathogenic bacteria components e31:TLR11:Uropathogenic components e32:profilin like molecules e33:Profilin like molecules e34:Poly IC e35:Poly IC:TLR3 e36:ssRNA e37:TLR7:ssRNA e38:Imidazoquinolines e39:TLR7:Imidazoquinolines e4: e40:TLR8:ssRNA e41:TLR8:Imidazoquinolines e42:CpG motifs e43:TLR9:CpGmotifs e44:Hemozoin e45:TLR9:Hemozoin e46:p50 e47:NF-KappaB:IKappaB e48:NF-KappaB:IKappaB{p} e49:NF-KappaB:IKappaB{p}{ub} e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:26s proteosome e64:proteosome remnant e65:NF-kappaB{active} e66:NF-kappaB{active} e67:LPS;TLR4:TIRAP:MyD88 e68:LPS:TLR4:TIRAP e69:TRAF6{ub} e7: e70:TAK1{active} e71:Uev1A e72:IKK-gamma{ub} e73:NAK e74:IKK e75:MAPKs{active} e76:AP1{p} e77:Inflammatory cytokines e78:LPS:TLR4:TRAM e79:LPS:TLR4:TRAM:TRIF e8:TLR2:PGN e80:TRIF:RIP1{ub} e81:RIP1 e82:TRIF:TRAF6:RIP1{p} e83:dsRNA:TLR3:TRIF e84:dsRNA:TLR3:TRIF:TRAF3 e85:TRAF3:TBK1:IKK-i e86:IRF-3{p} e87:IRF3{p}:IRF3{p} e88:IRF3{p}:IRF3{p} e89:TBK1:TANK e9:Lipoarabinomannan e90:TBK1:IKK-i e91:IRF3:ISRE e92:ISRE e93:TLR9:CpGmotifs:MyD88 e94:TLR9:CpGmotifs:MyD88:IRAk-4:IRAk1:TRAF6:TRAF3:IRf7 e95:IRAK1 e96:IRF7 e97:TLR9:CpGmotifs:MyD88:IRAk-4:IRAk1:TRAF6:TRAF3:IRf7{p} e98:IRF7{p}:IRF7{p} e99:TLR9:CpGmotifs:MyD88:IRAk-4:IRAk1:TRAF6:TRAF3

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p46 p47 p48 p49 p5 p50 p51 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
563.0, 1230.0
25.0, 25.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p56

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
544.0, 1163.0
23.0, 23.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
631.0, 1114.0
26.0, 26.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p32

p82

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
676.0, 475.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p25 p49 p69 p92 p93 p112

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
477.0, 1300.0
22.0, 22.0

ATF-2

--

MO000000062

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m96

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000000062

--

Go back
822.0, 633.0
20.0, 20.0

RIP1{ub}

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

p47

p46 p35

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
742.0, 773.0
20.0, 20.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p110

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
589.0, 392.0
21.0, 21.0

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
1125.0, 1452.0
22.0, 22.0

RelB

--

MO000000194

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p105

true true true true

csml-variable:Double

m167

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
1029.0, 1305.0
22.0, 22.0

p52

--

MO000000196

cso30:c:Protein

cso30:i:CC_CellComponent

--

p102

p105

true true true true

csml-variable:Double

m168

10

false

infinite

0

unit false false false
TRANSPATHMO000000196

--

Go back
969.0, 1444.0
21.0, 21.0

p105

--

MO000000199

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p101

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
1101.0, 1488.0
22.0, 22.0

p100{p}

--

MO000000202

cso30:c:Protein

cso30:i:CC_CellComponent

--

p104

p102

true true true true

csml-variable:Double

m173

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
493.0, 744.0
21.0, 21.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p61 p103

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
477.0, 697.0
22.0, 22.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p107 p113

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
593.0, 297.0
22.0, 22.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75 p35

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
521.0, 593.0
22.0, 22.0

IkappaB

--

MO000000215

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m186

10

false

infinite

0

unit false false false
TRANSPATHMO000000215

--

Go back
487.0, 430.0
26.0, 26.0

IKK{active}

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26 p38 p109

p27

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
308.0, 1355.0
24.0, 24.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p82

p83

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
970.0, 1037.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p97 p98

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1222.0, 1465.0
20.0, 20.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p94

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1110.0, 269.0
20.0, 20.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p60 p68

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
587.0, 251.0
33.0, 33.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p37 p108 p111

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
436.0, 364.0
24.0, 24.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p108

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
462.0, 654.0
20.0, 20.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p36 p86 p89

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1209.0, 893.0
22.0, 22.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p90 p91 p94

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1360.0, 259.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
990.0, 1134.0
20.0, 20.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86 p89

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
1021.0, 1496.0
22.0, 22.0

Caspase-8/10

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86 p89

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
1169.0, 860.0
22.0, 22.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p61 p86 p89

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
578.0, 849.0
20.0, 20.0

TANK

--

MO000019326

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m3897

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000019326

--

Go back
1111.0, 894.0
18.0, 18.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57 p90 p91

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1300.0, 275.0
23.0, 23.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10 p11

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
512.0, 195.0
23.0, 23.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
389.0, 196.0
21.0, 21.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p3 p4 p5 p7

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
1064.0, 599.0
23.5, 23.5

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p17

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1300.0, 1147.0
24.0, 24.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
717.0, 196.0
22.5, 22.5

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
525.0, 256.0
22.0, 22.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p108

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
762.0, 353.0
20.0, 20.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p76

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
1375.0, 1090.0
26.0, 26.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
1368.0, 615.0
24.0, 24.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1178.0, 353.0
20.0, 20.0

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p67

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
800.0, 923.0
24.0, 24.0

AP1

--

MO000036852

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m15167

10

false

infinite

0

unit false false false
TRANSPATHMO000036852

--

Go back
883.0, 383.0
18.0, 18.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61 p70 p77

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
998.0, 309.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p46 p50 p35

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1118.0, 385.0
20.0, 20.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
1053.0, 632.0
22.0, 22.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p50

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
764.0, 263.0
24.0, 24.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p108

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
1013.0, 468.0
21.0, 21.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
1061.0, 732.0
22.0, 22.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p23

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
446.0, 133.0
19.5, 19.5

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
1029.0, 520.0
22.0, 22.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p19

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
384.0, 755.0
24.0, 24.0

TLR11

--

MO000042130

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15

true true true true

csml-variable:Double

m19944

10

false

infinite

0

unit false false false
TRANSPATHMO000042130

--

Go back
510.0, 1469.0
20.0, 20.0

ZBP1

--

MO000061425

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p95

true true true true

csml-variable:Double

m36323

10

false

infinite

0

unit false false false
TRANSPATHMO000061425

--

Go back
357.75, 176.7980960525007
985.0344802064056, 1430.2700652597005

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
370.08862423038346, 243.5132456669568
908.6292939302023, 1278.1859240225442

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
852.5, 1185.0
22.323946008998497, 27.335444092651223

IRF7{p}:IRF7{p}

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65 p66

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
595.0, 1336.0
42.40484429065743, 22.615916955017298

IFN-alpha

--

e101

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p65 p66

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
381.5, 555.0
28.49568728207011, 39.76142411451644

TLR1:TLR2:Triacyl lipopeptides

--

e102

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p67

p68

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
383.0, 626.0
25.411764705882355, 42.352941176470594

TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88

--

e103

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p68 p74

p70

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
379.0, 686.0
25.411764705882355, 42.352941176470594

TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4

--

e104

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p70

p71

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
379.0, 954.0
25.411764705882355, 42.352941176470594

TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4{p}

--

e105

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p71

p72

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
379.0, 1030.0
25.411764705882355, 42.352941176470594

TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4{p}:IRAK1

--

e106

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p72

p73

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
379.0, 1106.0
25.411764705882355, 42.352941176470594

TLR1:TLr2:Triacyllioppeptides:TIRAP:MyD88:IRAK-4{p}:IRAK1{p}

--

e107

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p73

p74

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
525.5, 851.0
21.025662389601735, 25.745709048491925

IRAK-4{p}:IRAK1{p}

--

e108

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74 p81

p75

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
475.5, 275.0
24.60524866948064, 34.33290512020555

IRAK4{p}:IRAK1{p}:TRAF6

--

e109

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75

p36 p76

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
380.5, 250.0
22.198202148651614, 42.96426222319666

TLR2:Lipoarabinomannan:TLR2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1293.0, 836.0
22.588235294117645, 37.64705882352942

LPS;TLR4:TIRAP:MyD88:IRAK-4

--

e110

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p77

p78

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1301.0, 936.0
22.588235294117645, 37.64705882352942

LPS;TLR4:TIRAP:MyD88:IRAK-4{p}

--

e111

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p78

p79

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
1297.0, 1008.0
22.588235294117645, 37.64705882352942

LPS;TLR4:TIRAP:MyD88:IRAK-4{p}:IRAK1

--

e112

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p79

p80

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
1297.0, 1084.0
22.588235294117645, 37.64705882352942

LPS;TLR4:TIRAP:MyD88:IRAK-4{p}:IRAK1{p}

--

e113

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p80

p81

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
302.0, 1215.0
43.44827586206896, 24.620689655172413

cyclohexamide

--

e114

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p69

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
379.5, 1403.0
25.931458699472753, 39.894551845342704

TNF-alpha receptor

--

e115

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p83

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
384.5, 1277.0
22.225389169041875, 43.016882262661696

TNF-alpha:receptor

--

e116

cso30:c:Complex

cso30:i:CC_NuclearOuterMembrane

--

p83

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
1198.0, 1290.5
28.295254833040417, 18.391915641476274

RIG-1

--

e117

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p87

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
1248.0, 1333.0
16.514499532273152, 38.110383536014965

Mda5

--

e118

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p88

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
1115.0, 1190.5
26.399999999999995, 19.8

IPS-1

--

e119

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p84 p85

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
296.0, 412.5
32.59005836184343, 20.097202656470113

Hemagglutinin

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
788.0, 968.0
23.823529411764707, 39.70588235294119

RIG-1:IPS-1:RNA:FADD:Caspase 8/10,TRA:F3:NEMO

--

e120

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

p90 p92

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
948.5, 1307.0
23.16113048265737, 32.317856487428884

RIG-1:RNA:IPS-1

--

e121

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

p86

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
908.0, 1411.0
23.823529411764707, 39.70588235294119

Mda5:IPS-1:RNA:FADD:Caspase 8/10,TRA:F3:NEMO

--

e122

cso30:c:Complex

cso30:i:CC_Cytosol

--

p89

p91 p93

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
1188.0, 1175.0
31.816608996539806, 16.968858131487888

RNA

--

e123

cso30:c:mRNA

cso30:i:CC_Extracellular

--

--

p87 p88

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
1129.5, 1282.0
20.731711381436426, 25.385769038493585

RIG-1:RNA

--

e124

cso30:c:Complex

cso30:i:CC_Cytosol

--

p87

p84

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
1121.5, 1350.0
20.731711381436426, 25.385769038493585

Mda5:RNA

--

e125

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

p85

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
964.5, 1363.0
23.16113048265737, 32.317856487428884

Mda5:RNA:IPS-1

--

e126

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

p89

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
1158.0, 1421.0
20.0, 20.0

STAT1{p}

--

e127

cso30:c:Protein

cso30:i:CC_CellComponent

--

p94

--

true true true true

csml-variable:Double

m131

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
539.0, 1454.5
49.700185725656674, 10.76837357389228

dsDNA

--

e128

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p95

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
522.0, 1394.5
60.0, 17.0

ZBP1:dsDNA

--

e129

cso30:c:Complex

cso30:i:CC_Cytosol

--

p95

p96

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
379.5, 327.0
25.09361982021486, 48.56829642622232

Hemagglutinin:TLR2

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
750.5, 1453.0
19.57845476234172, 27.318774086988448

ZBP1:dsDNA:TBK1:IKKi

--

e130

cso30:c:Complex

cso30:i:CC_Cytosol

--

p96

p97

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
862.0, 1024.0
27.68292682926829, 22.146341463414632

IRF7{p}

--

e131

cso30:c:Protein

cso30:i:CC_Extracellular

--

p99

p100

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
875.0, 1470.0
18.0, 18.0

ubiquitin

--

e132

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p101 p102

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
485.0, 617.0
22.0, 22.0

IKK-beta{p}

--

e133

cso30:c:Protein

cso30:i:CC_CellComponent

--

p107 p113

--

true true true true

csml-variable:Double

m137

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
776.0, 1491.5
24.10142885892534, 14.862547796337294

p50

--

e134

cso30:c:Protein

cso30:i:CC_Cytosol

--

p101

--

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
457.5, 1059.0
20.748041993001163, 25.405765705715712

Ikk-alpha:IKK-alpha

--

e135

cso30:c:Complex

cso30:i:CC_Cytosol

--

p103

p104

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
461.0, 1236.0
22.0, 22.0

p100

--

e136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p104

true true true true

csml-variable:Double

m140

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
705.5, 1494.0
20.666388935177476, 25.305782369605065

p52:RelB

--

e137

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p105

p106

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
614.0, 1181.0
36.3840830449827, 19.40484429065744

mRNA

--

e138

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p106

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
698.0, 348.0
19.764705882352942, 32.94117647058823

TRAF6{ub}:TABs:TAK1

--

e139

cso30:c:Complex

cso30:i:CC_Extracellular

--

p37

p38 p39

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
298.0, 506.5
27.346221441124772, 17.77504393673111

tGPI-mutin

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
602.0, 495.0
19.764705882352942, 32.94117647058823

IKK-gamma{ub}:TABs:TAK1

--

e140

cso30:c:Complex

cso30:i:CC_Extracellular

--

p108

p109 p110

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
753.0, 425.0
22.764705882352946, 37.94117647058824

RIP1:TRAF6:TAK1:TRIF

--

e141

cso30:c:Complex

cso30:i:CC_Cytosol

--

p111

p112

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
384.5, 404.0
23.30607322955492, 45.108528831396626

tGPI-mutin:TLR2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p4

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
578.5, 191.0
26.55357440426595, 32.5145809031828

TLR2:TLR1

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
661.5, 170.0
21.84477088357816, 42.28020171015128

Triacyl lipopeptide:TLR1:TLR2

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p67

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
606.0, 51.0
43.574432296047114, 24.692178301093357

Tri-acyl Lipopeptide

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
786.5, 191.0
26.439260123312767, 32.374604232627895

TLR2:TLR6

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p8

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
357.75, 176.7980960525007
985.0344802064056, 1430.2700652597005

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
856.5, 172.0
23.67309800482351, 45.818899364174534

Diacyl lipopeptide:TLR2:TLR6

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
812.0, 42.0
47.03111858704793, 26.65096719932717

Di-acyl Lipopeptide

--

e21

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1297.5, 331.0
21.097127822845863, 40.833150624862974

LPS:TLR4

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p33 p43 p69

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1402.0, 390.0
44.8107653490328, 25.392767031118595

MPLA

--

e23

cso30:c:SmallMolecule

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p10

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1293.5, 391.0
21.097127822845863, 40.833150624862974

MPLA:TLR4

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1411.0, 459.5
25.586637150332063, 15.778426242704775

Envelope protein

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1292.5, 454.0
22.041876781407584, 42.661696996272745

Envelope protein:TLR4

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1305.5, 1198.0
21.2126726595045, 41.05678579258935

Flagellin:TLR5

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1390.0, 1198.0
44.987384356602185, 25.492851135407903

Lamina Propria

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1293.5, 1262.0
21.803990352992763, 42.201271650953736

TLR5:Lamina Propria

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
377.450689604128, 196.4987856566287
945.6331009981501, 1390.8686860514454

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
304.0, 820.5
31.66959578207381, 20.585237258347977

Uropathogenic bacteria components

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
381.5, 802.0
21.84477088357816, 42.28020171015128

TLR11:Uropathogenic components

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
308.0, 920.5
31.985940246045704, 20.790861159929698

profilin like molecules

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
381.5, 854.0
21.470949353212013, 41.55667616750713

Profilin like molecules

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1368.0, 676.0
39.58788898233809, 22.43313708999159

Poly IC

--

e34

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p17

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1058.0, 668.0
19.690607734806626, 21.87845303867404

Poly IC:TLR3

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1371.0, 568.5
41.12256084192063, 21.246656434992328

ssRNA

--

e36

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p18 p20

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1059.0, 570.0
19.790055248618785, 21.988950276243084

TLR7:ssRNA

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1364.0, 511.0
40.874684608915054, 23.162321278385196

Imidazoquinolines

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p19 p21

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1006.0, 561.0
19.740331491712677, 21.93370165745856

TLR7:Imidazoquinolines

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
413.8969653717653, 230.9749924638527
872.7405494628753, 1321.9162724369962

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
971.0, 521.0
18.497237569060797, 20.552486187845314

TLR8:ssRNA

--

e40

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p20

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
935.0, 469.0
18.497237569060797, 20.552486187845314

TLR8:Imidazoquinolines

--

e41

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p21

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1377.0, 788.0
53.65145228215768, 14.307053941908714

CpG motifs

--

e42

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p22

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1095.0, 782.0
18.49723756906076, 20.552486187845297

TLR9:CpGmotifs

--

e43

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p22

p60

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1367.0, 739.0
42.91841883936081, 24.32043734230446

Hemozoin

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p23

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1010.0, 684.0
19.292817679557995, 21.43646408839779

TLR9:Hemozoin

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
643.0, 374.5
25.279999999999998, 18.96

p50

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
717.0, 568.0
21.033149171270715, 23.370165745856355

NF-KappaB:IKappaB

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p27

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
733.0, 608.0
21.033149171270715, 23.370165745856355

NF-KappaB:IKappaB{p}

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
749.0, 647.0
21.033149171270715, 23.370165745856355

NF-KappaB:IKappaB{p}{ub}

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
894.503555648266, 439.66815845865017
282.05385621906623, 470.88652267081255

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
495.0, 1006.0
426.09580468015594, 386.42207984960163

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
541.0215208034433, 1015.1576415230934
249.15099193588267, 374.5199624004352

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
500.55432147627766, 1011.1575842279719
414.9871617276009, 376.10691139365736

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
501.34779597288866, 1011.951058724583
413.4002127343785, 374.5199624004352

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
495.0, 1006.0
426.09580468015594, 386.42207984960163

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
495.0, 1006.0
426.09580468015594, 386.42207984960163

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
505.00801922841686, 1011.951058724583
413.4002127343785, 374.5199624004352

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
806.0420026715476, 1164.6948993222181
26.62012469128147, 24.098218141581146

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
736.2162469697716, 1275.781328847771
75.38007717805363, 68.23880670855392

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
495.0, 1006.0
426.09580468015594, 386.42207984960163

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
894.503555648266, 439.66815845865017
282.05385621906623, 470.88652267081255

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
595.4283836870417, 1177.7227792532306
13.493828052201641, 6.497028321430424

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
594.9777865729975, 1158.3471033493295
46.186204189532376, 83.13516754115825

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
614.3534624768993, 1212.4187570346357
7.209553824707486, 7.209553824707487

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
763.5, 689.0
16.88790501106863, 27.385791909841014

26s proteosome

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p29

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
765.0, 729.0
22.22860425043079, 21.487650775416423

proteosome remnant

--

e64

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p29 p101 p102

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
684.0, 772.0
24.0, 24.0

NF-kappaB{active}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29 p49 p69 p92 p93 p112

p30

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
712.0, 1043.0
24.0, 24.0

NF-kappaB{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p31 p32 p42 p56

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1245.0, 188.0
22.588235294117645, 37.64705882352942

LPS;TLR4:TIRAP:MyD88

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p34 p81

p77

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1288.5, 227.0
22.48247384841256, 31.370893741971013

LPS:TLR4:TIRAP

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
817.0, 309.0
22.0, 22.0

TRAF6{ub}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

p61 p37 p111

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
894.503555648266, 439.66815845865017
282.05385621906623, 470.88652267081255

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
935.0, 251.0
33.0, 33.0

TAK1{active}

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p107

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
752.5, 381.0
14.028577178506744, 22.749044073254176

Uev1A

--

e71

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36 p76

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
458.0, 469.0
20.0, 20.0

IKK-gamma{ub}

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p108

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1173.0, 402.0
14.410664172123477, 33.25537885874648

NAK

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p113

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
447.0, 322.0
26.0, 26.0

IKK

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p109

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
798.0, 861.0
20.0, 20.0

MAPKs{active}

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39 p110

p40

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
992.0, 1000.0
24.0, 24.0

AP1{p}

--

e76

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p41

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
TRANSPATHMO000036852

--

Go back
725.0, 1147.0
45.98615916955018, 24.52595155709343

Inflammatory cytokines

--

e77

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p41 p42

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1107.5, 193.0
25.118186823270335, 35.04863277665628

LPS:TLR4:TRAM

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1005.0, 189.0
21.794117647058822, 36.32352941176472

LPS:TLR4:TRAM:TRIF

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
465.5, 182.0
21.858364393773293, 42.306511729883795

TLR2:PGN

--

e8

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
825.5, 486.0
20.984835860689877, 25.69571738043659

TRIF:RIP1{ub}

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p111

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
856.0, 711.0
24.0, 24.0

RIP1

--

e81

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
871.5, 615.0
17.668746559001654, 24.65406496604882

TRIF:TRAF6:RIP1{p}

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p48

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
921.5, 594.0
20.59643971370894, 28.739218205175263

dsRNA:TLR3:TRIF

--

e83

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p50 p58

p51

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
963.0, 867.0
18.97058823529412, 31.617647058823533

dsRNA:TLR3:TRIF:TRAF3

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p58

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
1046.5, 959.0
27.974857772068273, 39.03468526335107

TRAF3:TBK1:IKK-i

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p53

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1214.0, 1117.0
28.0, 28.0

IRF-3{p}

--

e86

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53 p97 p98

p54

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1117.5, 1143.0
20.364272621229787, 24.935844025995664

IRF3{p}:IRF3{p}

--

e87

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p55

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
857.5, 1247.0
20.364272621229787, 24.935844025995664

IRF3{p}:IRF3{p}

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p56 p59

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
571.5, 911.0
21.376770538243623, 26.175637393767705

TBK1:TANK

--

e89

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p57

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
290.0, 279.0
43.77628259041211, 24.806560134566865

Lipoarabinomannan

--

e9

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
1160.5, 1030.0
22.81386435594067, 27.935344109315107

TBK1:IKK-i

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90 p91

p58 p96 p98 p99

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
702.0, 1298.5
60.0, 17.0

IRF3:ISRE

--

e91

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p59

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
734.0, 1340.5
60.0, 13.0

ISRE

--

e92

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p59

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
913.5, 766.0
20.091392916131397, 28.03450174343917

TLR9:CpGmotifs:MyD88

--

e93

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p60

p61

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
938.0, 815.0
19.14705882352941, 31.911764705882348

TLR9:CpGmotifs:MyD88:IRAk-4:IRAk1:TRAF6:TRAF3:IRf7

--

e94

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p61

p62

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
745.0, 494.6600000000001
22.72, 17.039999999999992

IRAK1

--

e95

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p61 p72 p79

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
623.0, 830.5
26.98732139263434, 16.64218152545784

IRF7

--

e96

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p61 p99

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1054.0, 840.0
19.14705882352941, 31.911764705882348

TLR9:CpGmotifs:MyD88:IRAk-4:IRAk1:TRAF6:TRAF3:IRf7{p}

--

e97

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p62

p63

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
916.5, 1001.0
22.323946008998497, 27.335444092651223

IRF7{p}:IRF7{p}

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63 p100

p64

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1050.0, 799.0
19.14705882352941, 31.911764705882348

TLR9:CpGmotifs:MyD88:IRAk-4:IRAk1:TRAF6:TRAF3

--

e99

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p63

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
389.0, 132.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042032 MO000019397

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155701*m3964*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand) PMID: 18029230 LR2 recognizes various PAMPs, including peptidoglycan from Gram-positive bacteria, lipoarabinomannan from mycobacteria, hemagglutinin protein from measles virus and tGPI-mutin from Trypanosoma.

Go back
1354.0, 393.0
20.0, 20.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m3961*m23*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR4 recognizes bacterial LPS and synthetic MPLA as well as envelope proteins from respiratory syncytial virus (RSV) and mouse mammary tumor virus (MMTV).

Go back
732.0, 967.0
23.0, 23.0

p63

p100

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e131

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c304 : 1

m135*0.1

nodelay

--

true

0

false

PMID: 18029230 IPS-1 interacts with TRAF3, which subsequently activates the TBK1/IKKi?IRF3/7 axis

Go back
924.0, 1499.0
23.0, 23.0

p101

p101

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e132 MO000000199

e134 e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c305 : 1
stoichiometry:c306 : 1
stoichiometry:c308 : 1
stoichiometry:c307 : 1

m136*m171*0.1

nodelay

--

true

0

false

PMID: 18029230 Ubiquitin-dependent proteolytic degradation of the C-terminal region of p105 and p100 results in the generation of mature p50 and p52

Go back
1044.0, 1435.0
23.0, 23.0

p101

p102

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e132 MO000000202

MO000000196 e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c309 : 1
stoichiometry:c310 : 1
stoichiometry:c312 : 1
stoichiometry:c311 : 1

m136*m173*0.1

nodelay

--

true

0

false

PMID: 18029230 Ubiquitin-dependent proteolytic degradation of the C-terminal region of p105 and p100 results in the generation of mature p50 and p52

Go back
469.0, 969.0
21.0, 21.0

p103

p103

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000000210

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c314 : 1

m181*0.1

nodelay

--

true

0

false

PMID: 18029230 Importantly, p100 phosphorylation is mediated by the IKKgreek small letter alpha?IKKgreek small letter alpha homodimer, which does not require IKKbeta and NEMO.

Go back
450.0, 1161.0
20.0, 20.0

p104

p104

cso30:i:ME_Phosphorylation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e135 e136

MO000000202

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c315 : 1
stoichiometry:c316 : 1
stoichiometry:c317 : 1

m139*m140*0.1

nodelay

--

true

0

false

Go back
1074.0, 1397.0
19.0, 19.0

p105

p105

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000196 MO000000194

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c318 : 1
stoichiometry:c319 : 1
stoichiometry:c320 : 1

m168*m167*0.1

nodelay

--

true

0

false

PMID: 18029230 p52 then forms a heterodimer with RelB to regulate expression of target genes.

Go back
588.0, 1275.0
23.0, 23.0

p106

p106

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e137

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c321 : 1
stoichiometry:c322 : 1

m141*0.1

nodelay

--

true

0

false

PMID: 18029230 p52 then forms a heterodimer with RelB to regulate expression of target genes.

Go back
557.0, 548.0
23.0, 23.0

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000211 e70

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c324 : 1
stoichiometry:c156 : 1
stoichiometry:c325 : 1

m182*m71*0.1

nodelay

--

true

0

false

PMID: 18029230,11460167 It has been suggested that TAK1 can phosphorylate IKK¦Â and increase its enzymatic activity

Go back
481.0, 396.0
21.0, 21.0

p37

p108

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000016588 MO000022125 MO000016574 MO000041541

e140

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c328 : 1
stoichiometry:c329 : 1
stoichiometry:c330 : 1
stoichiometry:c331 : 1
stoichiometry:c332 : 1
stoichiometry:c333 : 1

m73*m1583*m6433*m1573*m19389*0.1

nodelay

--

true

0

false

PMID: 18029230,17496917 Ubiquitinated NEMO and TRAF6 subsequently recruit a protein kinase complex involving TAK1 (transforming growth factor-¦Â-activated kinase-1) and TABs (TAK1 binding proteins) (TAB1, TAB2 and TAB3), Ubiquitin-mediated activation of TAK1 and IKK, which then activates two distinct pathways involving the IKK complex and the mitogen-activated protein kinase (MAPK) (ERK, JNK, p38) pathway

Go back
585.0, 444.0
21.0, 21.0

p38

p109

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e140 e74

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c335 : 1
stoichiometry:c336 : 1

m144*m75*0.1

nodelay

--

true

0

false

PMID: 18029230,17496917 Ubiquitinated NEMO and TRAF6 subsequently recruit a protein kinase complex involving TAK1 (transforming growth factor-¦Â-activated kinase-1) and TABs (TAK1 binding proteins) (TAB1, TAB2 and TAB3), Ubiquitin-mediated activation of TAK1 and IKK, which then activates two distinct pathways involving the IKK complex and the mitogen-activated protein kinase (MAPK) (ERK, JNK, p38) pathway

Go back
1358.0, 461.0
20.0, 20.0

p10

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e25 MO000019394

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m25*m3961*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR4 recognizes bacterial LPS and synthetic MPLA as well as envelope proteins from respiratory syncytial virus (RSV) and mouse mammary tumor virus (MMTV).

Go back
560.0, 659.0
23.0, 23.0

p39

p110

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e140 MO000000077

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1
stoichiometry:c339 : 1

m144*m76*0.1

nodelay

--

true

0

false

PMID: 18029230,17496917 Ubiquitinated NEMO and TRAF6 subsequently recruit a protein kinase complex involving TAK1 (transforming growth factor-¦Â-activated kinase-1) and TABs (TAK1 binding proteins) (TAB1, TAB2 and TAB3), Ubiquitin-mediated activation of TAK1 and IKK, which then activates two distinct pathways involving the IKK complex and the mitogen-activated protein kinase (MAPK) (ERK, JNK, p38) pathway

Go back
825.0, 408.0
21.0, 21.0

p111

p111

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 e80 MO000016574

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c341 : 1
stoichiometry:c342 : 1
stoichiometry:c343 : 1

m70*m82*m1573*0.1

nodelay

--

true

0

false

PMID: 18029230,16115877 Notably, RIP1 is polyubiquitinated to form a complex with TRAF6 and TAK1, resulting in NF-¦ÊB activation

Go back
781.0, 649.0
21.0, 21.0

p112

p112

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e141 MO000000058

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c344 : 1
stoichiometry:c108 : 1
stoichiometry:c346 : 1

m145*m46*0.1

nodelay

--

true

0

false

PMID: 18029230,16115877 Notably, RIP1 is polyubiquitinated to form a complex with TRAF6 and TAK1, resulting in NF-¦ÊB activation

Go back
950.0, 398.0
19.0, 19.0

p113

p113

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e73 MO000000211

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c347 : 1

m74*m182*0.1

nodelay

--

true

0

false

PMID: 18029230 t has been shown that NAK enhances the enzymatic activity of IKK¦Â through direct phosphorylation, contributing to NF-¦ÊB activation.

Go back
1374.0, 1149.0
20.0, 20.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022185 MO000019399

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR5 detects bacterial flagellin expressed in intestinal epithelial cells as well as CD11c-positive lamina propria in DCs

Go back
1366.0, 1241.0
20.0, 20.0

p12

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019399 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m3966*m28*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR5 detects bacterial flagellin expressed in intestinal epithelial cells as well as CD11c-positive lamina propria in DCs

Go back
308.0, 755.0
23.0, 23.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000042130

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m30*m19944*0.1

nodelay

--

true

0

false

PMID: 18029230 In mice, TLR11 recognizes as yet unknown components of uropathogenic bacteria, and a profilin-like molecule of Toxoplasma gondii.

Go back
312.0, 863.0
23.0, 23.0

p14

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 e33 MO000042130

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m32*m33*m19944*0.1

nodelay

--

true

0

false

PMID: 18029230 In mice, TLR11 recognizes as yet unknown components of uropathogenic bacteria, and a profilin-like molecule of Toxoplasma gondii.

Go back
1185.0, 616.0
21.0, 21.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR3, 7, 8 and 9, which are localized to endosomes, detect nucleic acids derived from viruses and bacteria. PMID: 18029230 TLR3 recognizes dsRNA, which is produced by many viruses during replication, and poly IC.

Go back
1185.0, 676.0
21.0, 21.0

p16

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000019398

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m34*m3965*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR3, 7, 8 and 9, which are localized to endosomes, detect nucleic acids derived from viruses and bacteria. PMID: 18029230 TLR3 recognizes dsRNA, which is produced by many viruses during replication, and poly IC.

Go back
1173.0, 568.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m19940*m36*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR7 recognizes ssRNA derived from various viruses and synthetic imidazoquinolines with antitumor properties.

Go back
1169.0, 512.0
21.0, 21.0

p18

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m19940*m38*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR7 recognizes ssRNA derived from various viruses and synthetic imidazoquinolines with antitumor properties.

Go back
301.0, 196.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e9

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3964*m9*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand) PMID: 18029230 LR2 recognizes various PAMPs, including peptidoglycan from Gram-positive bacteria, lipoarabinomannan from mycobacteria, hemagglutinin protein from measles virus and tGPI-mutin from Trypanosoma.

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1173.0, 464.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000042007

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m36*m19823*0.1

nodelay

--

true

0

false

PMID:18029230 Human TLR8 also participates in the recognition of ssRNA and imidazoquinolines, whereas the function of mouse TLR8 remains unclear.

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1045.0, 380.0
21.0, 21.0

p20

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 MO000042007

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m38*m19823*0.1

nodelay

--

true

0

false

PMID:18029230 Human TLR8 also participates in the recognition of ssRNA and imidazoquinolines, whereas the function of mouse TLR8 remains unclear.

Go back
1170.0, 785.0
19.0, 19.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000042012

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m42*m19828*0.1

nodelay

--

true

0

false

PMID: 18029230 LR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from Plasmodium.

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1178.0, 733.0
19.0, 19.0

p22

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e44 MO000042012

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m44*m19828*0.1

nodelay

--

true

0

false

PMID: 18029230 LR9 recognizes CpG DNA motifs present in bacterial and viral genomes as well as non-nucleic acids such as hemozoin from Plasmodium.

Go back
685.0, 401.0
21.0, 21.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000193 e46

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m166*m47*0.1

nodelay

--

true

0

false

PMID: 18029230,17072327 The most frequently activated form of NF-¦ÊB in TLR signaling is a heterodimer composed of RelA and p50

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625.0, 553.0
21.0, 21.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000058 MO000000215

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m46*m186*0.1

nodelay

--

true

0

false

PMID: 18029230 Under unstimulated conditions, NF-¦ÊB is sequestered in the cytoplasm as an inactive form by interaction with a family of inhibitor proteins known as I¦ÊB proteins PMID: 18029230 The RelA?p50 heterodimer is kept in the cytoplasm as a latent and inactive form by interaction with I¦ÊB proteins in unstimulated cells

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581.0, 696.0
21.0, 21.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016599 MO000000211 MO000000210

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m1593*m182*m181*0.1

nodelay

--

true

0

false

PMID: 18029230 Stimulation with TLR ligands triggers the rapid phosphorylation of specific serine residues of I¦ÊB proteins by a multiprotein complex termed the IKK complex, which consists of two catalytic components, IKKgreek small letter alpha and IKK¦Â, and a regulatory component, NEMO (NF-¦ÊB essential modifier, also known as IKK¦Ã).

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602.0, 601.0
19.0, 19.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000248 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m207*m48*0.1

nodelay

--

true

0

false

PMID: 18029230 Stimulation with TLR ligands triggers the rapid phosphorylation of specific serine residues of I¦ÊB proteins by a multiprotein complex termed the IKK complex, which consists of two catalytic components, IKKgreek small letter alpha and IKK¦Â, and a regulatory component, NEMO (NF-¦ÊB essential modifier, also known as IKK¦Ã).

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653.0, 648.0
21.0, 21.0

p28

p28

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18029230 Phosphorylated I¦ÊB proteins are subsequently polyubiquitinated and degraded by the 26S proteasome, allowing NF-¦ÊB to move into the nucleus.

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649.0, 688.0
21.0, 21.0

p29

p29

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e49 e63

e64 e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m63*m64*0.1

nodelay

--

true

0

false

PMID: 18029230 Phosphorylated I¦ÊB proteins are subsequently polyubiquitinated and degraded by the 26S proteasome, allowing NF-¦ÊB to move into the nucleus.

Go back
301.0, 340.0
21.0, 21.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000019397

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c7 : 1

m12*m3964*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand) PMID: 18029230 LR2 recognizes various PAMPs, including peptidoglycan from Gram-positive bacteria, lipoarabinomannan from mycobacteria, hemagglutinin protein from measles virus and tGPI-mutin from Trypanosoma.

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702.0, 890.0
20.0, 20.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18029230 Phosphorylated I¦ÊB proteins are subsequently polyubiquitinated and degraded by the 26S proteasome, allowing NF-¦ÊB to move into the nucleus.

Go back
613.0, 1068.0
22.0, 22.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e66

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18029230,17072327 This pathway is called the ¡Æcanonical pathway¡Ç and is responsible for TLR-mediated induction of inflammatory cytokines such as tumor necrosis factor-greek small letter alpha (TNF-greek small letter alpha) and IL-6

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729.0, 1116.0
22.0, 22.0

p31

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e66

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18029230,17072327 This pathway is called the ¡Æcanonical pathway¡Ç and is responsible for TLR-mediated induction of inflammatory cytokines such as tumor necrosis factor-greek small letter alpha (TNF-greek small letter alpha) and IL-6

Go back
1153.0, 296.0
21.0, 21.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000022528

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m22*m6810*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR4 uses four adaptors, MyD88, TIRAP, TRIF and TRAM. TLR3 uses TRIF as the sole adaptor PMID: 18029230

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1238.0, 290.0
19.0, 19.0

p33

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e68

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m1572*m69*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR4 uses four adaptors, MyD88, TIRAP, TRIF and TRAM. TLR3 uses TRIF as the sole adaptor PMID: 18029230

Go back
845.0, 545.0
22.0, 22.0

p46

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000000212 MO000000065

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c137 : 1
stoichiometry:c140 : 1

m18998*m183*m83*0.1

nodelay

--

true

0

false

PMID: 18029230,15064760 he TRIF C-terminal region contains the Rip homotypic interaction motif (RHIM), which is responsible for interaction with RIP1 (receptor-interacting protein-1), a member of the RIP family involved in TNF-receptor-mediated NF-¦ÊB activation 29 E. Meylan et al., RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappaB activation

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481.0, 545.0
21.0, 21.0

p35

p36

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016599 e71 MO000022136 e109

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c348 : 1
stoichiometry:c107 : 1

m1593*m72*m6443*m113*0.1

nodelay

--

true

0

false

PMID: 18029230,17496917,16858426 TRAF6 is a RING-domain E3 ubiquitin ligase, and together with E2, Ubc13 and Uev1A, it promotes Lys63-linked polyubiquitination of target proteins, including TRAF6 itself and NEMO

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677.0, 288.0
21.0, 21.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022125 MO000016574 MO000041541 MO000016588 e69

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c323 : 1
stoichiometry:c326 : 1
stoichiometry:c101 : 1
stoichiometry:c327 : 1

m6433*m1573*m19389*m1583*m70*0.1

nodelay

--

true

0

false

PMID: 18029230,17496917 Ubiquitinated NEMO and TRAF6 subsequently recruit a protein kinase complex involving TAK1 (transforming growth factor-¦Â-activated kinase-1) and TABs (TAK1 binding proteins) (TAB1, TAB2 and TAB3), Ubiquitin-mediated activation of TAK1 and IKK, which then activates two distinct pathways involving the IKK complex and the mitogen-activated protein kinase (MAPK) (ERK, JNK, p38) pathway

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529.0, 388.0
21.0, 21.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 e139

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c334 : 1
stoichiometry:c116 : 1

m75*m143*0.1

nodelay

--

true

0

false

PMID: 18029230 The activated TAK1 complex then activates the IKK complex consisting of IKKgreek small letter alpha, IKK¦Â and NEMO, which catalyzes the phosphorylation of I¦ÊB proteins (P)

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820.0, 692.0
23.0, 23.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e139

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c118 : 1
stoichiometry:c120 : 1

m76*m143*0.1

nodelay

--

true

0

false

PMID: 18029230 Simultaneously, the TAK1 complex activates the MAPK pathway, which results in the phosphorylation (P) and activation of AP-1 PMID: 18029230,17496917 Ubiquitinated NEMO and TRAF6 subsequently recruit a protein kinase complex involving TAK1 (transforming growth factor-¦Â-activated kinase-1) and TABs (TAK1 binding proteins) (TAB1, TAB2 and TAB3), Ubiquitin-mediated activation of TAK1 and IKK, which then activates two distinct pathways involving the IKK complex and the mitogen-activated protein kinase (MAPK) (ERK, JNK, p38) pathway

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301.0, 448.0
21.0, 21.0

p1

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e15 MO000019397

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m15*m3964*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand) PMID: 18029230 LR2 recognizes various PAMPs, including peptidoglycan from Gram-positive bacteria, lipoarabinomannan from mycobacteria, hemagglutinin protein from measles virus and tGPI-mutin from Trypanosoma.

Go back
881.0, 861.0
21.0, 21.0

p40

p40

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e75 MO000036852

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m77*m15167*0.1

nodelay

--

true

0

false

Go back
818.0, 1149.0
19.0, 19.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 18029230 NF-¦ÊB and AP-1 control inflammatory responses through the induction of inflammatory cytokines

Go back
790.0, 1085.0
19.0, 19.0

p41

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e66

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18029230 NF-¦ÊB and AP-1 control inflammatory responses through the induction of inflammatory cytokines

Go back
1094.0, 329.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000041132

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m22*m19005*0.1

nodelay

--

true

0

false

PMID: 18029230 TIRAP and TRAM are required for the activation of the MyD88- and the TRIF-dependent pathways, respectively.

Go back
1054.0, 293.0
19.0, 19.0

p43

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c131 : 1
stoichiometry:c133 : 1

m18998*m80*0.1

nodelay

--

true

0

false

PMID: 18029230 TIRAP and TRAM are required for the activation of the MyD88- and the TRIF-dependent pathways, respectively.

Go back
793.0, 565.0
22.0, 22.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 MO000041125

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c340 : 1
stoichiometry:c139 : 1

m83*m18998*0.1

nodelay

--

true

0

false

PMID: 18029230,15064760 he TRIF C-terminal region contains the Rip homotypic interaction motif (RHIM), which is responsible for interaction with RIP1 (receptor-interacting protein-1), a member of the RIP family involved in TNF-receptor-mediated NF-¦ÊB activation 29 E. Meylan et al., RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappaB activation

Go back
861.0, 661.0
22.0, 22.0

p47

p47

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e81

MO000000065

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 18029230,16115877 Notably, RIP1 is polyubiquitinated to form a complex with TRAF6 and TAK1, resulting in NF-¦ÊB activation

Go back
853.0, 253.0
21.0, 21.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 MO000016574

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c155 : 1

m85*m1573*0.1

nodelay

--

true

0

false

PMID:18029230 These findings indicate that TRIF recruits TRAF6 and RIP1 via distinct regions and that these molecules appear to cooperative to facilitate TAK1 activation, resulting in robust NF-¦ÊB activation

Go back
597.0, 788.0
21.0, 21.0

p48

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m46*0.1

nodelay

--

true

0

false

PMID:18029230 These findings indicate that TRIF recruits TRAF6 and RIP1 via distinct regions and that these molecules appear to cooperative to facilitate TAK1 activation, resulting in robust NF-¦ÊB activation

Go back
513.0, 132.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000019396

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3964*m3963*0.1

nodelay

--

true

0

false

Go back
946.0, 545.0
20.0, 20.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041446

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR3 uses TRIF as the sole adaptor.

Go back
1123.0, 874.0
17.0, 17.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e83 MO000016963

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m86*m1872*0.1

nodelay

--

true

0

false

PMID: 18029230 TRIF recruits TRAF3, which then interacts with TBK1 and IKKi.

Go back
1062.0, 1037.0
19.0, 19.0

p53

p53

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e85 MO000007694

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m88*m977*0.1

nodelay

--

true

0

false

PMID: 18029230 These kinases mediate phosphorylation of IRF3 (P). Phosphorylated IRF3 dimerizes and translocates into the nucleus to regulate transcription

Go back
1025.0, 1088.0
22.0, 22.0

p54

p54

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 18029230 These kinases mediate phosphorylation of IRF3 (P). Phosphorylated IRF3 dimerizes and translocates into the nucleus to regulate transcription

Go back
1037.0, 1205.0
21.0, 21.0

p55

p55

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m90*0.1

nodelay

--

true

0

false

PMID: 18029230 These kinases mediate phosphorylation of IRF3 (P). Phosphorylated IRF3 dimerizes and translocates into the nucleus to regulate transcription

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673.0, 1184.0
21.0, 21.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e88 MO000000062 e66

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c167 : 1

m91*m96*m67*0.1

nodelay

--

true

0

false

PMID: 18029230 These kinases mediate phosphorylation of IRF3 (P). Phosphorylated IRF3 dimerizes and translocates into the nucleus to regulate transcription PMID: 18029230,16979567 n the nucleus, IRF3 together with NF-¦ÊB and ATF2/c-Jun form a multiprotein complex called an enhanceosome, which binds the promoter?enhancer region of the IFN-¦Â gene

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642.0, 877.0
19.0, 19.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019326 MO000019331

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m3897*m3902*0.1

nodelay

--

true

0

false

PMID: 18029230 TBK1 was identified as a protein kinase interacting with TANK (also known as I-TRAF), a TRAF-binding protein

Go back
1041.0, 916.0
21.0, 21.0

p51

p58

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e84 e90

e85 e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c171 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1

m87*m93*0.1

nodelay

--

true

0

false

PMID: 18029230 TRIF recruits TRAF3, which then interacts with TBK1 and IKKi.

Go back
810.0, 1285.0
19.0, 19.0

p59

p59

cso30:i:ME_DNABinding

cso30:i:CC_Nucleolus

--

e88 e92

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m91*m95*0.1

nodelay

--

true

0

false

PMID: 18029230 This allows IRF3 to form a homodimer, translocate into the nucleus and bind its target sequences, such as IFN-stimulated response element (ISRE).

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617.0, 116.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m18*m16*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand) PMID: 18029230 TLR2/1 and TLR2/6 discriminate the lipid structures between triacyl- and diacyl-lipopeptide, respectively

Go back
920.0, 691.0
23.0, 23.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e43 MO000016573

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m43*m1572*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR1, 2 and 6 utilize MyD88 and TIRAP as adaptors while TLR5, 7, 9 and 11 utilize MyD88.

Go back
998.0, 718.0
20.0, 20.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e93 MO000039077 e95 MO000000210 e69 MO000016963 e96

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c182 : 1

m97*m17258*m99*m181*m70*m1872*m100*0.1

nodelay

--

true

0

false

PMID: 18029230 In pDCs, IRF7 forms a signaling complex with MyD88, IRAK4, TRAF6, IRAK1 and IKKalpha PMID: 18029230 IRAK1, but not IRAK4, physically interacts with IRF7 PMID: 18029230 TRAF3 binds to a MyD88?IRAK1?IRF7 complex and pDCs derived from TRAF3-deficient mice have defects in IFN-greek small letter alpha production

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973.0, 805.0
21.0, 21.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_EndosomeLumen

--

e94

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m98*0.1

nodelay

--

true

0

false

PMID: 18029230 In response to ligand stimulation, IRF7 is phosphorylated by IRAK1 and IKKalpha

Go back
876.0, 903.0
23.0, 23.0

p63

p63

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e97

e98 e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m101*0.1

nodelay

--

true

0

false

PMID: 18029230 n response to ligand stimulation, IRF7 is phosphorylated by IRAK1 and IKKgreek small letter alpha, dimerizes and is then translocated into the nucleus.

Go back
917.0, 1068.0
21.0, 21.0

p64

p64

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e98

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m102*0.1

nodelay

--

true

0

false

PMID: 18029230 n response to ligand stimulation, IRF7 is phosphorylated by IRAK1 and IKKgreek small letter alpha, dimerizes and is then translocated into the nucleus.

Go back
701.0, 1232.0
21.0, 21.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e100

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 18029230 IRF7 regulates the expression of type I IFNs, including IFN-greek small letter alpha and IFN-¦Â

Go back
633.0, 1232.0
21.0, 21.0

p65

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e100

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 18029230 IRF7 regulates the expression of type I IFNs, including IFN-greek small letter alpha and IFN-¦Â

Go back
485.0, 329.0
21.0, 21.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022528 e17

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c199 : 1
stoichiometry:c201 : 1

m6810*m17*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR1, 2 and 6 utilize MyD88 and TIRAP as adaptors

Go back
537.0, 424.0
21.0, 21.0

p67

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c204 : 1

m1572*m106*0.1

nodelay

--

true

0

false

PMID: 18029230 TLR1, 2 and 6 utilize MyD88 and TIRAP as adaptors

Go back
568.0, 1007.0
23.0, 23.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e114 MO000000058 e22

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c105 : 1
stoichiometry:c112 : 1
stoichiometry:c237 : 1

m46*m22*0.1

nodelay

--

true

0

false

PMID: 18029230 Pretreatment of MyD88-deficient cells with cyclohexamide, a protein synthesis inhibitor, results in an abrogation of LPS-induced NF-¦ÊB activation, thus suggesting that late phase NF-¦ÊB activation is likely to require protein synthesis. PMID: 18029230 LPS induces TNF-greek small letter alpha synthesis via a MyD88-independent mechanism, and the newly synthesized TNF-greek small letter alpha subsequently binds TNF receptor to initiate the late phase NF-¦ÊB activation in an autocrine manner, at least in MEF cells.

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717.0, 120.0
21.0, 21.0

p6

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000019422

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m3964*m3987*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand) PMID: 18029230 TLR2/1 and TLR2/6 discriminate the lipid structures between triacyl- and diacyl-lipopeptide, respectively

Go back
517.0, 636.0
21.0, 21.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000039077 e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m17258*m107*0.1

nodelay

--

true

0

false

PMID: 18029230 MyD88 recruits TRAF6 and members of the IRAK family PMID: 18029230,15229469 Upon TLR activation, through its death domain, MyD88 interacts with the death domains of members of the IRAK (IL-1 receptor-associated kinase) family of protein kinases, including IRAK1, IRAK2, IRAK4 and IRAK-M,

Go back
453.0, 784.0
21.0, 21.0

p71

p71

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e104

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m108*0.1

nodelay

--

true

0

false

PMID: 18029230 IRAK4 is initially activated, which in turn phosphorylates and activates IRAK1.

Go back
453.0, 944.0
21.0, 21.0

p70

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e105 e95

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m109*m99*0.1

nodelay

--

true

0

false

PMID: 18029230 MyD88 recruits TRAF6 and members of the IRAK family PMID: 18029230,15229469 Upon TLR activation, through its death domain, MyD88 interacts with the death domains of members of the IRAK (IL-1 receptor-associated kinase) family of protein kinases, including IRAK1, IRAK2, IRAK4 and IRAK-M,

Go back
445.0, 1012.0
21.0, 21.0

p71

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 18029230 IRAK4 is initially activated, which in turn phosphorylates and activates IRAK1.

Go back
512.0, 999.0
18.0, 18.0

p74

p74

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e107

e103 e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1

m111*0.1

nodelay

--

true

0

false

PMID: 18029230 After IRAK4 and IRAK1 have been sequentially phosphorylated, they dissociate from MyD88 and interact with TRAF6.

Go back
545.0, 321.0
21.0, 21.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e108 MO000000212

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1

m112*m183*0.1

nodelay

--

true

0

false

PMID: 18029230 After IRAK4 and IRAK1 have been sequentially phosphorylated, they dissociate from MyD88 and interact with TRAF6.

Go back
709.0, 249.0
21.0, 21.0

p35

p76

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e109 MO000022136 e71

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c103 : 1
stoichiometry:c109 : 1
stoichiometry:c222 : 1

m113*m6443*m72*0.1

nodelay

--

true

0

false

PMID: 18029230,17496917,16858426 TRAF6 is a RING-domain E3 ubiquitin ligase, and together with E2, Ubc13 and Uev1A, it promotes Lys63-linked polyubiquitination of target proteins, including TRAF6 itself and NEMO

Go back
1005.0, 349.0
21.0, 21.0

p70

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 MO000039077

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m68*m17258*0.1

nodelay

--

true

0

false

PMID: 18029230 MyD88 recruits TRAF6 and members of the IRAK family PMID: 18029230,15229469 Upon TLR activation, through its death domain, MyD88 interacts with the death domains of members of the IRAK (IL-1 receptor-associated kinase) family of protein kinases, including IRAK1, IRAK2, IRAK4 and IRAK-M,

Go back
1209.0, 848.0
21.0, 21.0

p71

p78

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e110

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 18029230 IRAK4 is initially activated, which in turn phosphorylates and activates IRAK1.

Go back
1117.0, 956.0
21.0, 21.0

p70

p79

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e111 e95

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m115*m99*0.1

nodelay

--

true

0

false

PMID: 18029230 MyD88 recruits TRAF6 and members of the IRAK family PMID: 18029230,15229469 Upon TLR activation, through its death domain, MyD88 interacts with the death domains of members of the IRAK (IL-1 receptor-associated kinase) family of protein kinases, including IRAK1, IRAK2, IRAK4 and IRAK-M,

Go back
825.0, 108.0
21.0, 21.0

p6

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m21*m19*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand) PMID: 18029230 TLR2/1 and TLR2/6 discriminate the lipid structures between triacyl- and diacyl-lipopeptide, respectively

Go back
1213.0, 1040.0
21.0, 21.0

p71

p80

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e112

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1

m116*0.1

nodelay

--

true

0

false

PMID: 18029230 IRAK4 is initially activated, which in turn phosphorylates and activates IRAK1.

Go back
651.0, 922.0
18.0, 18.0

p74

p81

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e113

e67 e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1
stoichiometry:c235 : 1

m117*0.1

nodelay

--

true

0

false

PMID: 18029230 After IRAK4 and IRAK1 have been sequentially phosphorylated, they dissociate from MyD88 and interact with TRAF6.

Go back
489.0, 1356.0
21.0, 21.0

p82

p82

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c240 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 18029230 LPS induces TNF-greek small letter alpha synthesis via a MyD88-independent mechanism, and the newly synthesized TNF-greek small letter alpha subsequently binds TNF receptor to initiate the late phase NF-¦ÊB activation in an autocrine manner, at least in MEF cells.

Go back
449.0, 1332.0
21.0, 21.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e115 MO000000289

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c242 : 1
stoichiometry:c243 : 1

m119*m230*0.1

nodelay

--

true

0

false

PMID: 18029230 LPS induces TNF-greek small letter alpha synthesis via a MyD88-independent mechanism, and the newly synthesized TNF-greek small letter alpha subsequently binds TNF receptor to initiate the late phase NF-¦ÊB activation in an autocrine manner, at least in MEF cells.

Go back
1030.0, 1233.0
19.0, 19.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e119 e124

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c259 : 1
stoichiometry:c250 : 1

m123*m128*0.1

nodelay

--

true

0

false

PMID: 18029230 RIG-I and Mda5 contain CARD-like structures that mediate interaction with the adaptor IPS-1

Go back
1066.0, 1301.0
19.0, 19.0

p84

p85

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e119 e125

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c258 : 1
stoichiometry:c260 : 1

m123*m129*0.1

nodelay

--

true

0

false

PMID: 18029230 RIG-I and Mda5 contain CARD-like structures that mediate interaction with the adaptor IPS-1

Go back
961.0, 1225.0
21.0, 21.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e121 MO000016599 MO000016899 MO000016900

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c261 : 1
stoichiometry:c247 : 1
stoichiometry:c252 : 1
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m1872*m125*m1593*m1814*m1815*0.1

nodelay

--

true

0

false

PMID: 18029230 IPS-1 interacts with TRAF3, which subsequently activates the TBK1/IKKi?IRF3/7 axis PMID: 18029230,16585540 In parallel, IPS-1 interacts with FADD and caspase-8/-10, causing NF-¦ÊB activation PMID: 18029230,17468758 NEMO is shown to participate in both NF-¦ÊB and IRF3 activation in RIG-I and Mda5 signaling pathways

Go back
1133.0, 1224.0
21.0, 21.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e123 e117

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c245 : 1
stoichiometry:c248 : 1

m127*m121*0.1

nodelay

--

true

0

false

PMID: 18029230 Cells express cytoplasmic RNA helicases (RIG-I and Mda5) that recognize RNA derived from actively replicating RNA viruses.

Go back
1161.0, 1332.0
21.0, 21.0

p87

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e123 e118

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c256 : 1
stoichiometry:c257 : 1

m127*m122*0.1

nodelay

--

true

0

false

PMID: 18029230 Cells express cytoplasmic RNA helicases (RIG-I and Mda5) that recognize RNA derived from actively replicating RNA viruses.

Go back
1017.0, 1416.0
21.0, 21.0

p86

p89

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016899 MO000016963 MO000016599 e126 MO000016900

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c262 : 1
stoichiometry:c263 : 1
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1

m1814*m1872*m1593*m130*m1815*0.1

nodelay

--

true

0

false

PMID: 18029230 IPS-1 interacts with TRAF3, which subsequently activates the TBK1/IKKi?IRF3/7 axis PMID: 18029230,16585540 In parallel, IPS-1 interacts with FADD and caspase-8/-10, causing NF-¦ÊB activation PMID: 18029230,17468758 NEMO is shown to participate in both NF-¦ÊB and IRF3 activation in RIG-I and Mda5 signaling pathways

Go back
1357.0, 324.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019394

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 18029230 These microbial components include bacterial lipopolysaccharide (LPS; TLR4 ligand), lipoproteins (TLR2 ligand), flagellin (TLR5 ligand), bacterial CpG DNA (TLR9 ligand), viral single-stranded RNA (TLR7 ligand) and viral double-stranded RNA (TLR3 ligand)

Go back
872.0, 980.0
23.0, 23.0

p90

p90

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e120 MO000019331 MO000016608

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c273 : 1
stoichiometry:c274 : 1

m124*m3902*m1599*0.1

nodelay

--

true

0

false

PMID:18029230 IPS-1 interacts with TRAF3, which subsequently activates the TBK1/IKKi?IRF3/7 axis

Go back
852.0, 1352.0
23.0, 23.0

p90

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e122 MO000019331 MO000016608

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c276 : 1
stoichiometry:c277 : 1
stoichiometry:c278 : 1

m126*m3902*m1599*0.1

nodelay

--

true

0

false

PMID:18029230 IPS-1 interacts with TRAF3, which subsequently activates the TBK1/IKKi?IRF3/7 axis

Go back
737.0, 893.0
21.0, 21.0

p92

p92

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e120 MO000000058

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c279 : 1
stoichiometry:c102 : 1
stoichiometry:c281 : 1

m124*m46*0.1

nodelay

--

true

0

false

PMID: 18029230,16585540 In parallel, IPS-1 interacts with FADD and caspase-8/-10, causing NF-¦ÊB activation

Go back
601.0, 1413.0
21.0, 21.0

p92

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e122 MO000000058

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c104 : 1
stoichiometry:c284 : 1

m126*m46*0.1

nodelay

--

true

0

false

PMID: 18029230,16585540 In parallel, IPS-1 interacts with FADD and caspase-8/-10, causing NF-¦ÊB activation

Go back
1221.0, 1404.0
21.0, 21.0

p94

p94

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016608 MO000013119

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c285 : 1
stoichiometry:c286 : 1
stoichiometry:c287 : 1

m1599*m1357*0.1

nodelay

--

true

0

false

PMID: 18029230 IKKi can phosphorylate a serine residue in STAT1 that is crucial for the transcriptional activity

Go back
466.0, 1429.0
19.0, 19.0

p95

p95

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

MO000061425 e128

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c289 : 1
stoichiometry:c290 : 1

m36323*m132*0.1

nodelay

--

true

0

false

PMID: 18029230,17618271 Recently, DAI (DNA-dependent activator of interferon-regulatory factors, also known as DLM-1 and ZBP1) has been identified as a cytosolic sensor for dsDN PMID: 18029230 DAI is an IFN-inducible gene that has dsDNA-binding properties

Go back
630.0, 1462.0
19.0, 19.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e129 e90

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c291 : 1
stoichiometry:c292 : 1
stoichiometry:c293 : 1

m133*m93*0.1

nodelay

--

true

0

false

PMID: 18029230 Whereas DAI activates IRF3 via direct interactions with TBK1 and IRF3, pathways for NF-¦ÊB activation remain unknown.

Go back
822.0, 1454.0
19.0, 19.0

p96

p97

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e130 MO000007694

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c294 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1

m134*m977*0.1

nodelay

--

true

0

false

PMID: 18029230 Whereas DAI activates IRF3 via direct interactions with TBK1 and IRF3, pathways for NF-¦ÊB activation remain unknown.

Go back
930.0, 1105.0
19.0, 19.0

p98

p98

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e90 MO000007694

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c298 : 1
stoichiometry:c299 : 1

m93*m977*0.1

nodelay

--

true

0

false

PMID:18029230 IPS-1 interacts with TRAF3, which subsequently activates the TBK1/IKKi?IRF3/7 axis

Go back
846.0, 918.0
19.0, 19.0

p98

p99

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e90 e96

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c300 : 1
stoichiometry:c301 : 1
stoichiometry:c302 : 1

m93*m100*0.1

nodelay

--

true

0

false

PMID:18029230 IPS-1 interacts with TRAF3, which subsequently activates the TBK1/IKKi?IRF3/7 PMID: 18029230,12702806 TBK1 and IKKi can also phosphorylate and activate IRF7, which is the member of IRF family most closely related to IRF3

Go back
418.0, 143.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 477.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1249.0, 233.97569713079395

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.9100221314997, 301.1964739358571

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 499.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.6120680655489, 277.1381345104895

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.6455899500913, 499.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.6045160900932, 499.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 573.8709592807993

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.44807344330496, 496.61622849028214

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.0, 499.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.3430000067614, 277.6492059044267

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
329.4759018794317, 431.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.83095942838094, 397.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.58937609791104, 370.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.897579368605, 361.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.0, 269.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.0, 274.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.0, 345.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.367306591753, 409.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0613012044827, 472.72987951680994

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
714.0, 381.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
762.0, 720.6083002246481

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.64717014237686, 217.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.1389634193575, 715.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
818.0, 871.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
824.0, 885.9571543086322

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 882.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.1490207276536, 1022.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 1159.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 1061.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.0501711869566, 1104.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1120.98833818622, 340.43180206412

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.1752892054838, 355.3428562876811

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.0, 152.6603445091646

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1105.0, 235.93454417853468

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1074.1927794053147, 228.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 308.14115091028873

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.5777087639997, 232.15541752799933

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
867.3292085270566, 329.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.0, 319.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 331.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 574.7181105699019

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0540812353584, 594.3940914119202

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
809.0, 519.3887333080002

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0, 161.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 567.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.0, 690.9796695986458

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.4404466988269, 654.7455923043988

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
864.3515661880954, 281.9922713427028

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 264.1373188220515

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.9883951577431, 408.43074679772144

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
499.0, 418.2950039375453

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.9844219541314, 499.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 787.3151918984429

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
959.7354436625493, 329.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 143.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.1980017756614, 568.0581393801375

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.2724472327433, 565.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
942.0, 622.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.7766576685863, 874.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.0, 883.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
874.0, 264.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.358927898942, 281.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
982.0, 888.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.0, 998.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
628.0, 76.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 1047.3745886903887

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 1052.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.8898707868398, 1102.322852587015

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1047.0, 1106.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.2469006966983, 1160.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.7808717026281, 1219.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.5565957717955, 1200.6263777987338

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
595.3033886328969, 1200.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 863.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.9949479994173, 887.284264817757

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 144.31049238896205

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
600.0667921655595, 892.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1067.7432031476085, 942.56916668859

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.4795369723441, 1267.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
771.0, 1309.506083455352

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.9162638485062, 1296.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.0, 1205.0751651220137

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
689.2324348988572, 1067.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
950.1175644130494, 712.6524343698543

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.2541672804256, 289.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.9169928638811, 714.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.0, 137.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 738.2399915200255

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
895.0, 401.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.0365441543581, 738.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.0, 512.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 729.412672997025

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.0, 331.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.1424346412794, 741.125475263584

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 733.2906988878473

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
957.0, 823.2065506721576

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 821.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
410.0, 135.80258428422147

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
906.5845589235054, 859.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 926.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.0, 825.028121803566

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.0, 1028.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.753241807694, 1089.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.6832761980976, 1202.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.4408979277846, 1253.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
661.8431258711989, 1201.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.0497011787119, 1253.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
512.1070902829529, 200.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
400.0, 161.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 149.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.9953183842869, 340.2736492899384

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.1253212925127, 350.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.7200437696894, 282.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.0, 450.42046561172106

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.66981183581976, 445.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.5493929985034, 398.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.0, 647.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.3158220461108, 652.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 722.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.98829155848455, 805.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 131.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 960.197769023179

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.34020345180534, 512.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.81480191509274, 965.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 1031.2159204962816

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
408.223472969005, 1033.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 1021.4352642519865

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
405.6255083362558, 675.5568979069623

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.0, 884.9549652501944

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
536.0, 349.9938314670777

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
573.2080133580728, 314.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 69.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.85994340570034, 303.1159660434202

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 263.06227967003986

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 266.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.7404061669101, 214.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 365.0102810673346

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.0, 370.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1237.9909451017954, 855.0

c226

c226

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1230.0, 869.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1145.9849872259235, 956.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.0, 512.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.0, 136.4195317762593

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.0, 970.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1241.6921915811265, 1030.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1234.0, 1057.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.7313079795342, 935.0559369945577

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 226.17594975966188

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0437687993774, 873.7927985842801

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.0, 803.1757060026598

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.0, 1031.5218600328799

c238

c238

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
511.10192895220814, 1140.0

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 129.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 1367.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
405.0, 1359.0899458438937

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
332.0, 1346.3479689797996

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.58317520481955, 1310.5455257366611

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1159.7759056409234, 1250.5352429058848

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.1554175279994, 1206.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
481.0, 674.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1141.43180206412, 1245.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1084.352465419694, 1210.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1369.3897804297073, 283.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.6568542494924, 1252.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.9691115068547, 882.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.367808234867, 1154.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0, 1154.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1160.0955145420758, 1192.0

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1175.5689290811056, 1192.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1189.9553806775862, 1344.8437524961075

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.2299027111483, 1349.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.8906201660432, 1324.4130023147422

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.1020362515915, 1251.68253731564

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1323.0, 297.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.6169894699772, 1318.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
962.0, 1253.914322908596

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.1098298940276, 882.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.0, 674.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.7486663819678, 1253.8065463480707

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.5474549596428, 1011.5818427047461

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 1390.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.4062548214392, 1444.9896781549733

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
939.9911565538811, 1427.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 937.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1326.7365962981012, 338.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.8117886200879, 630.4895824153249

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 989.0

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
902.4791880593903, 906.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
902.7404143579143, 907.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
895.0, 994.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.1214751973158, 1381.145770236779

c275

c275

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
874.8797420933065, 912.0

c276

c276

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.894464393577, 915.0

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.0, 1061.7625617079318

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
758.2065767803005, 920.8047565563683

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1317.0, 298.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
704.1787353966505, 803.3413650827405

c281

c281

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
629.9976048708568, 1424.1957455737622

c282

c282

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 803.9319403181759

c284

c284

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.0, 915.0

c285

c285

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1232.0, 1433.0

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1185.7504216358204, 1418.0

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.8874480940946, 1452.4164522465671

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.76114000116263, 1442.9402850002907

c289

c289

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1382.0, 403.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.0, 1415.399257096111

c290

c290

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
563.0, 1412.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
655.232673534705, 1053.0

c292

c292

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 1467.3916865490037

c293

c293

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.0, 1464.4607722807734

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.7602750929591, 1065.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
841.0, 1148.142453570098

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
956.6586216862937, 1048.0

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
951.4757828400085, 1065.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.0, 1115.0

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
410.0, 151.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1322.906973581205, 404.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.5071778537757, 933.7644675204782

c300

c300

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
650.0, 845.0

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.0, 937.0

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.3743796643629, 987.1013746251994

c303

c303

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.0, 981.0

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.0, 1485.0

c305

c305

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
949.9750571488127, 1465.0

c306

c306

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.6312164658858, 757.8319303394134

c307

c307

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
807.9741116400947, 1500.6430735193626

c308

c308

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.0, 1450.4585794082545

c309

c309

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1385.9853479730496, 468.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.8255999415424, 1462.48291759204

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.9430183617902, 757.4389947521265

c311

c311

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1042.028432229131, 1334.9336200532975

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.8577715147383, 765.0

c313

c313

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.03471347254214, 990.0

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.6214926735981, 1084.0

c315

c315

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
463.15151876571286, 1188.9166915142762

c316

c316

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 1176.0

c317

c317

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.0, 1327.0

c318

c318

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1097.4929882637098, 1421.8161052203986

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.0, 298.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.7232092162002, 1410.0

c320

c320

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.7215033179397, 1305.0816956341375

c321

c321

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.0, 1207.5894663844042

c322

c322

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.7181105699019, 278.0

c323

c323

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 578.0167701427321

c324

c324

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.829021351216, 571.0

c325

c325

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 305.42417907050265

c326

c326

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 309.0

c327

c327

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 424.55988858752204

c328

c328

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 384.0

c329

c329

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1322.9913606886246, 472.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.45225092871567, 278.0

c330

c330

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0111288665284, 284.0

c331

c331

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.2628635212419, 281.0

c332

c332

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.0, 416.0

c333

c333

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.8300782016946, 366.0

c334

c334

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
473.0, 346.0

c335

c335

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.9382230137094, 445.9922778767137

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.9542156749217, 528.0

c337

c337

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.7911752716327, 682.22846762196

c338

c338

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.0, 680.0

c339

c339

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1385.483960483215, 1116.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.968345173027, 329.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 437.0

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.0, 278.0

c342

c342

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.558052895341, 423.0

c343

c343

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.0, 463.0

c344

c344

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
709.8986360985804, 670.0

c346

c346

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.228905599633, 413.0

c347

c347

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 309.0

c348

c348

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1324.0, 1159.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1334.1331135275848, 1169.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1320.0, 1171.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1390.3149107106394, 1223.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1322.2926940551122, 1255.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.0, 207.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 786.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 767.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
331.0, 776.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.0, 894.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 875.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
336.4376015698018, 779.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1214.0, 627.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.0, 613.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1082.935983293789, 628.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1214.0, 687.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 225.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1088.0, 618.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1085.9874520661697, 680.4478945083833

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 535.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1202.0, 579.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.9981898404565, 579.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.0, 524.4062548214393

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1198.0, 523.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1033.661134181608, 526.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1201.147323226171, 483.5938517916905

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1034.0, 475.23012056396993

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
322.0, 215.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.7200437696894, 478.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1073.4209240369034, 397.98829155848455

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1028.0, 408.5313887422553

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.3000400080607, 400.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1197.0, 795.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1083.0, 748.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.9889426346601, 792.4204706649821

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1204.9932266050907, 743.3291328602096

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1083.0, 743.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.699943505067, 700.1704538739115

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 351.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.0, 404.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
668.0, 392.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.8999121222475, 422.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 570.9083398852216

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 566.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.0, 668.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 707.097553721736

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.5218515223521, 499.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.0, 716.8673816066733

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.61472041694367, 463.5606373501986

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
312.0, 369.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 456.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
628.7218109753595, 583.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 612.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.1795895597943, 625.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
674.0, 659.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.4147970583408, 663.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.992766725465, 699.3401177329985

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
670.0, 703.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.0, 709.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 796.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
323.16485939411723, 217.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.0, 910.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.7899827830846, 1058.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.6414582374399, 1090.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.0, 1067.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
665.0, 1127.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1181.6488945988958, 312.3440160867584

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1171.2491077284276, 324.3104923889621

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1174.0, 251.4003101204427

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1130.0, 281.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1262.48291759204, 256.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back