_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e4
_enti_e3
_enti_e2
_enti_e55
_enti_e53
_enti_e59
_enti_e56
_enti_e54
_enti_e51
_enti_e52
_enti_e50
_enti_e58
_enti_e57
_enti_e61
_enti_e62
_enti_e60
g2_fact_g2
g1_fact_g14
g2_fact_g12
g2_fact_g13
g1_fact_g1
p1_propro_p1
PMID: 18031244, 12816876
Others had shown that administration of LPS (lipopolysaccharide), an exogenous TLR4 agonist, promoted disease in rabbits and mice.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18031244, 16267105, 16025156, 11781369
Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [3136]. All of these have been shown to be TLR2 agonists in vitro.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18031244, 16267105, 16025156, 11781369
Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [3136]. All of these have been shown to be TLR2 agonists in vitro.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18031244, 16267105, 16025156, 11781369
Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [3136]. All of these have been shown to be TLR2 agonists in vitro.
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 18031244, 16267105, 16025156, 11781369
Other possibilities include HMGB1 (high-mobility group B1), biglycan, hyaluronic acid fragments, necrotic cells and SAA (serum amyloid A) [3136]. All of these have been shown to be TLR2 agonists in vitro.
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p5_propro_p6
PMID: 18031244
the proatherogenic TLR2 responses to the defined
synthetic exogenous agonist Pam3 CSK4 are mediated at least in part by BMDC, which can include
lymphocytes, monocytes/macrophages and dendritic cells.
c16 cso30:c:InputProcess connector
c17 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
LPS_enti_MO000016882
LPS
LPS: TLR4_enti_e5
LPS: TLR4
TLR4_enti_MO000019394
TLR4
TLR2_enti_MO000019397
TLR2
HMGB1_enti_MO000044940
HMGB1
hyaluronic acid fragments_enti_e6
hyaluronic acid fragments
biglycan_enti_e11
biglycan
serum amyloid A_enti_e12
serum amyloid A
HMGB1: TLR2_enti_e13
HMGB1: TLR2
biglycan: TLR2_enti_e14
biglycan: TLR2
hyaluronic acid fragments: TLR2_enti_e15
hyaluronic acid fragments: TLR2
serum amyloid A: TLR2_enti_e16
serum amyloid A: TLR2
Pam3CSK4_enti_e17
Pam3CSK4
Pam3CSK4: TLR2_enti_e18
Pam3CSK4: TLR2