1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18049472.csml convertedTime:2009.07.01.11:11

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Interferons at age 50: past, current and future impact on biomedicine.
Authors Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, Foster GR, Stark GR.
Affiliation Taussig Cancer Center, Case Comprehensive Cancer Center, Mellen Center forMultiple Sclerosis, and Lerner Research Institute, The Cleveland Clinic, 9500Euclid Avenue, Cleveland, Ohio 44195, USA. bordene@ccf.org
Abstract The family of interferon (IFN) proteins has now more than reached the potentialenvisioned by early discovering virologists: IFNs are not only antivirals with aspectrum of clinical effectiveness against both RNA and DNA viruses, but arealso the prototypic biological response modifiers for oncology, and showeffectiveness in suppressing manifestations of multiple sclerosis. Studies ofIFNs have resulted in fundamental insights into cellular signalling mechanisms,gene transcription and innate and acquired immunity. Further elucidation of themultitude of IFN-induced genes, as well as drug development strategies targetingIFN production via the activation of the Toll-like receptors (TLRs), will almostcertainly lead to newer and more efficacious therapeutics. Our goal is to offera molecular and clinical perspective that will enable IFNs or their TLR agonistinducers to reach their full clinical potential.
PMID 18049472
Model Abstract

Entity

G010228:IFN-beta G010430:VCAM-1 G010539:SOCS1 G010711:VEGF G011193:MIG G012252:CXCL10 MO000000011:ERK MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000048:AKT MO000000049:c-Jun MO000000058:NF-kappaB MO000000104:PKC MO000000212:TRAF6 MO000000248:IKK MO000000254:p50:RelA-p65:IkappaB-alpha{p} MO000000276:AP-1 MO000000277:p53 MO000000289:TNF-alpha MO000000308:VCAM-1 MO000004927:Fas MO000007384:IL-6 MO000007694:IRF-3 MO000008179:PKR MO000013119:STAT1 MO000013122:STAT3 MO000013291:p56 MO000014520:VEGF family MO000016574:TAK1 MO000016597:IL-1beta MO000016608:IKK-i MO000016632:p50:RelA-p65 MO000016658:IFN Type I MO000016660:IFNbeta MO000016665:IFNgamma: IFNgamma MO000016667:IFNomega MO000016882:LPS MO000016899:FADD MO000016900:Caspase-8 MO000016906:Caspase-10 MO000016917:MKK4 MO000016963:TRAF3 MO000017115:SOCS/CIS family MO000017268:MHC class II MO000017271:IP-10 MO000017793:Lp MO000017871:Apo2L MO000017876:XIAP MO000018132:CD14 MO000019331:TBK1 MO000019343:AKT{p} MO000019395:TLRs MO000019398:TLR3 MO000019399:TLR5 MO000019479:protein remnants MO000022185:flagellin MO000022224:dsRNA MO000022533:PACT MO000022570:eIF-2alpha MO000037579:PU.1 MO000038341:MKK4{p} MO000038375:STAT1{pS727} MO000038724:p50:RelA-p65:IkappaB-alpha MO000041125:TRIF MO000041437:dsRNA:TLR3: TLR3 {p}: CD14: TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000042007:TLR8: TLR8 MO000042012:TLR9: TLR9 MO000042126:TLR7 : TLR7 MO000060628:XAF1 MO000061281:RNASEL MO000063455:CD69 MO000066987:RIG-1 {activated} MO000068682:GBP1 MO000103999:Mda-5 {activated} e1: e10: e100:IFNAR1: IFNAR2: JAK1: TYK2 e101:IFNAR1: IFNAR2: JAK1: TYK2: IFNalpha e102:IFNAR1: IFNAR2: JAK1: TYK2: IFNbeta e103:IFNAR1: IFNAR2: JAK1: TYK2: IFNomega e104:IFNkappa: IFNAR1: IFNAR2: JAK1: TYK2 e105:IFNepsilon: IFNAR1: IFNAR2: JAK1: TYK2 e106:IFNtheta: IFNAR1: IFNAR2: JAK1: TYK2 e107:IFNtau: IFNAR1: IFNAR2: JAK1: TYK2 e108:IFN Type I: IFNAR1: IFNAR2: JAK1: TYK2 e109:2IFNGR1: 2IFNGR2: 2JAK2: 2JAK1 e11: e110:IFNgamma: IFNgamma: 2IFNGR1: 2IFNGR2: 2JAK2: 2JAK1 e111:IFNlambda e112:IFNlambda: IFNLR1: IL10R2: JAK1: Tyk2 e113:STAT1: STAT2: IRF9 e114:IFNLR1: IL10R2: JAK1: Tyk2 e115:IFN Type I: IFNAR1: IFNAR2: JAK1 {p}: TYK2 e116:TNFSF10 e117:IFN Type I: IFNAR1{p}: IFNAR2 {p}: JAK1 {p}: TYK2 e118:IFNlambda: IFNLR1: IL10R2: JAK1 {p}: Tyk2 e119:IFNlambda: IFNLR1 {p}: IL10R2 {p}: JAK1 {p}: Tyk2 e12:TLR1: TLR2 e120:IFNgamma: IFNgamma: 2IFNGR1: 2IFNGR2: 2JAK2 {p}: 2JAK1 [p} e121:IFNgamma: IFNgamma: 2IFNGR1 {p}: 2IFNGR2 {p}: 2JAK2 {p}: 2JAK1 [p} e122:STAT1 [p}: STAT2 {p}: IRF9 e123:IFNgamma: IFNgamma: 2IFNGR1 {p}: 2IFNGR2 {p}: 2JAK2 {p}: 2JAK1 [p}: STAT1: STAT3 e124:IFNgamma: IFNgamma: 2IFNGR1 {p}: 2IFNGR2 {p}: 2JAK2 {p}: 2JAK1 [p}: STAT1 [p}: STAT3 {p} e125:IFNAR1: IFNAR2: JAK1: TYK2: PI3K e126:IFNAR1: IFNAR2: JAK1: TYK2: PI3K: IFN Type I e127:CXCL11 e128:STAT3 {activated} e129:PI3K {activated} e13:TLR6: TLR2 e130: e131: e132:NF-kappaB {p} e133:ERK {activated} e134:AP-1 {p} e135:PU.1{p} e136:STAT3: NF-kappaB e137:OASs [actiavted} e138:OASs e139:ATP e14:Lipoteichoic acid e140:2'-to-5' linked oligoadenylate of 3?6 bases e141:2-5A: RNASEL e142:2-5A: RNASEL: RNASEL e143:ssRNA e144:RNA degradation products e145:RIG-1 e146:Mda-5 e147:PKR {activated} e148:GDP e149:eIF-2alpha {p} e15:Lp: TLR1: TLR2 e150:: EIF2B e151:EIF2B1 e152:eIF3 e153:p56: eIF3 e154:p54: eIF3 e155:p54 e156:HCV mRNA e157:GIP3 e158:Icam1 e159:IFN e16:Lipoteichoic acid: TLR6: TLR2 e160:CIITA e161:S1PR e162:cd69: S1PR e163:Mmp9 e164:FAS e165:APO2L e166:XIAP: p53: XAF1 e167:caspase e168:caspase {activated} e169:tumour-associated antigens e17:TLR4: TLR4 e170:carcinoembryonic antigen e171:TAG72 e172:PKC {p} e173: e174: e175: e176: e177: e178: e179: e18:LPS: TLR4: TLR4 e19:flagellin: TLR5 e2: e20:ssRNA e21:dsRNA: RIG-1 {activated} e22:dsRNA: Mda-5 {activated} e23:TLR ligand e24:TLR ligand: TLR e25:IFN e26:IPS-1 e27:dsRNA: RIG-1{activated}: IPS-1 e28:dsRNA: Mda-5 {activated}: IPS-1 e29:CpG DNA e3: e30:CpG DNA: TLR9: TLR9 e31:ssRNA: TLR8: TLR8 e32:ssRNA: TLR7 : TLR7 e33:Ptk e34:dsRNA:TLR3 {p} e35:dsRNA:TLR3: TLR3 {p} e36:dsRNA:TLR3: TLR3 {p}: CD14 e37:dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i e38:dsRNA:TLR3: TLR3 {p}: PI3K e39:dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i: IRF-3 e4: e40:dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i: IRF-3 {p} e41:IRF-3{p} e42:dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF6: TAK1 e43:IKK {activated} e44:ATF2 e45:ATF2 {activated} e46:JNK {activated} e47:p38 {activated} e48:c-Jun {activated} e49:c-Jun {nucleus} e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:ATF2 {nucleus} e64:p50:RelA-p65 {nucleus} e65:p50: RelA-p65: target genes e66:c-Jun: target genes e67:ATF2: target genes e68:dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i e69:IRF-3: IRF-3{p} {nucleus} e7: e70:IRF3{p}: target genes e71:TRAF3 {activated} e72:IKK-i e73:TRAF6: TAK1 e74:TRAF6: TAK1 {activated} e75:dsRNA: RIG-1 {activated}: IPS-1: FADD e76:dsRNA: Mda-5 {activated}: IPS-1: FADD e77:Caspase-10 [activated} e78:Caspase-8 {activated} e79:TBK1 {activated} e8: e80:LPS: TLR4: TLR4: TRIF e81:IRF-3: IRF-3 {p} e88:HCV protease e89:NS1 e9: e90:NS1: RIG-1 {activated} e91:quinolinamine imiquimod e92:quinolinamine imiquimod: TLR7: TLR7 e93:DMXAA e94:IFN-alpha1 e95:IFNalpha e96:IFNkappa e97:IFNepsilon e98:IFNtheta e99:IFNtau

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p130 p131 p132 p133 p134 p135 p136 p137 p138 p139 p14 p140 p141 p142 p143 p144 p145 p146 p147 p148 p149 p15 p150 p151 p152 p153 p154 p155 p156 p157 p158 p159 p16 p160 p161 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
791.0, 1569.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66 p67 p96 p124 p125

p126 p127 p159

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
1191.0, 1559.0
25.5, 25.5

VCAM-1

--

G010430

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p147

true true true true

csml-variable:Double

m93402

10

false

infinite

0

unit false false false
TRANSFACG010430

--

Go back
1097.0, 1377.0
30.0, 30.0

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p138

--

true true true true

csml-variable:Double

m93501

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
1071.0, 1591.0
26.0, 26.0

VEGF

--

G010711

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p156

p157

true true true true

csml-variable:Double

m93629

10

false

infinite

0

unit false false false
TRANSFACG010711

--

Go back
969.0, 1561.0
29.0, 29.0

MIG

--

G011193

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p143

--

true true true true

csml-variable:Double

m94078

10

false

infinite

0

unit false false false
TRANSFACG011193

--

Go back
1006.0, 1522.0
27.0, 27.0

CXCL10

--

G012252

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p142

p93

true true true true

csml-variable:Double

m95041

10

false

infinite

0

unit false false false
TRANSFACG012252

--

Go back
1324.0, 1900.0
32.0, 32.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p106

true true true true

csml-variable:Double

m140

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
653.0, 1115.0
25.0, 25.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p48 p94 p103 p108

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
592.0, 982.0
28.0, 28.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p47

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1026.0, 1088.0
32.0, 32.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p99 p110

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1429.0, 1241.0
30.0, 30.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p91 p100 p161

true true true true

csml-variable:Double

m131

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
642.0, 1156.0
29.0, 29.0

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
1241.0, 1253.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p105 p115

true true true true

csml-variable:Double

m138

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1528.0, 1380.0
32.0, 32.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p101

true true true true

csml-variable:Double

m135

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
563.0, 883.0
26.0, 26.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
741.0, 835.0
32.0, 32.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p49 p56 p160

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
806.0, 980.0
40.0, 40.0

p50:RelA-p65:IkappaB-alpha{p}

--

MO000000254

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p27

true true true true

csml-variable:Double

m208

10

false

infinite

0

unit false false false
TRANSPATHMO000000254

--

Go back
1342.0, 1989.0
26.0, 26.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p107

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1512.0, 1848.0
32.0, 32.0

p53

--

MO000000277

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p151

true true true true

csml-variable:Double

m220

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000277

--

Go back
1233.0, 2189.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p139

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1330.0, 1538.0
28.0, 28.0

VCAM-1

--

MO000000308

cso30:c:Protein

cso30:i:CC_CellComponent

--

p147

--

true true true true

csml-variable:Double

m243

10

false

infinite

0

unit false false false
InterProIPR003987
TRANSPATHMO000000308

--

Go back
1511.0, 1543.0
26.0, 26.0

Fas

--

MO000004927

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p148

true true true true

csml-variable:Double

m580

10

false

infinite

0

unit false false false
InterProIPR001368
TRANSPATHMO000004927

--

Go back
1763.0, 1435.0
26.0, 26.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p114

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
892.0, 734.0
34.0, 34.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p44

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
679.0, 1831.0
26.5, 26.5

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p128 p129

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
1521.0, 1101.0
30.0, 30.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88 p104

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1587.0, 1163.0
26.0, 26.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88 p114 p115

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
1000.0, 1896.0
32.0, 32.0

p56

--

MO000013291

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p132

true true true true

csml-variable:Double

m1377

10

false

infinite

0

unit false false false
InterProIPR000345
TRANSPATHMO000013291

--

Go back
1297.0, 1829.0
27.0, 27.0

VEGF family

--

MO000014520

cso30:c:Protein

cso30:i:CC_CellComponent

--

p157

--

true true true true

csml-variable:Double

m1553

10

false

infinite

0

unit false false false
TRANSPATHMO000014520

--

Go back
538.0, 944.0
30.0, 30.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1273.0, 2185.0
30.0, 30.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p140

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
890.0, 664.0
30.0, 30.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p43

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
849.0, 1087.0
34.0, 34.0

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

p32

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
1484.0, 154.0
28.0, 28.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77 p90

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
1792.0, 338.0
28.0, 28.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p126 p127 p159

p71 p95 p97 p142 p146 p147

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1986.0, 922.0
28.0, 28.0

IFNgamma: IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78 p137 p144 p153 p154 p155

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1783.0, 387.0
26.0, 26.0

IFNomega

--

MO000016667

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p72

true true true true

csml-variable:Double

m1641

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016667

--

Go back
298.0, 1052.0
29.0, 29.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1151.0, 501.0
28.0, 28.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p51

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
1029.0, 971.0
34.0, 34.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p55

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
1028.0, 894.0
28.0, 28.0

Caspase-10

--

MO000016906

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53 p52

true true true true

csml-variable:Double

m1821

10

false

infinite

0

unit false false false
TRANSPATHMO000016906

--

Go back
1529.0, 1461.0
30.0, 30.0

MKK4

--

MO000016917

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p102

true true true true

csml-variable:Double

m1832

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
910.0, 574.0
27.0, 27.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p41 p42

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1491.0, 757.0
30.0, 30.0

SOCS/CIS family

--

MO000017115

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p111 p112 p113

true true true true

csml-variable:Double

m2002

10

false

infinite

0

unit false false false
TRANSPATHMO000017115

--

Go back
1434.0, 990.0
28.0, 28.0

MHC class II

--

MO000017268

cso30:c:Protein

cso30:i:CC_CellComponent

--

p137

--

true true true true

csml-variable:Double

m2124

10

false

infinite

0

unit false false false
TRANSPATHMO000017268

--

Go back
1337.0, 1401.0
30.0, 30.0

IP-10

--

MO000017271

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93

--

true true true true

csml-variable:Double

m2127

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017271

--

Go back
303.0, 929.0
28.0, 28.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
1335.0, 1485.0
30.0, 30.0

Apo2L

--

MO000017871

cso30:c:Protein

cso30:i:CC_CellComponent

--

p98

p135 p152

true true true true

csml-variable:Double

m2615

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000017871

--

Go back
1518.0, 1790.0
28.0, 28.0

XIAP

--

MO000017876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p151

true true true true

csml-variable:Double

m2619

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000017876

--

Go back
779.0, 485.0
27.0, 27.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
910.0, 622.0
28.0, 28.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p57 p58

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1432.0, 1280.0
32.0, 32.0

AKT{p}

--

MO000019343

cso30:c:Protein

cso30:i:CC_CellComponent

--

p91 p100 p161

p23 p92 p101

true true true true

csml-variable:Double

m3914

10

false

infinite

0

unit false false false
TRANSPATHMO000019343

--

Go back
457.0, 1431.0
25.0, 25.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
579.0, 447.0
25.0, 25.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
454.0, 1332.0
24.0, 24.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
1253.0, 783.0
26.0, 26.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27 p62 p111 p112 p113

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
317.0, 1372.0
28.0, 28.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
768.0, 166.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p7 p116 p128

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
810.0, 1906.0
28.0, 28.0

PACT

--

MO000022533

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p129

true true true true

csml-variable:Double

m6814

10

false

infinite

0

unit false false false
InterProIPR001159
TRANSPATHMO000022533

--

Go back
912.0, 1848.0
32.0, 32.0

eIF-2alpha

--

MO000022570

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p130

true true true true

csml-variable:Double

m6843

10

false

infinite

0

unit false false false
InterProIPR003029
TRANSPATHMO000022570

--

Go back
540.0, 1254.0
28.0, 28.0

PU.1

--

MO000037579

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p109

true true true true

csml-variable:Double

m15836

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000037579

--

Go back
1434.0, 1482.0
28.0, 28.0

MKK4{p}

--

MO000038341

cso30:c:Protein

cso30:i:CC_CellComponent

--

p102

p103

true true true true

csml-variable:Double

m16555

10

false

infinite

0

unit false false false
TRANSPATHMO000038341

--

Go back
1440.0, 1176.0
32.0, 32.0

STAT1{pS727}

--

MO000038375

cso30:c:Protein

cso30:i:CC_CellComponent

--

p104

--

true true true true

csml-variable:Double

m16585

10

false

infinite

0

unit false false false
TRANSPATHMO000038375

--

Go back
824.0, 932.0
40.0, 40.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
828.0, 436.0
32.0, 32.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p59

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
776.0, 566.0
34.0, 34.0

dsRNA:TLR3: TLR3 {p}: CD14: TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p19 p24

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
609.0, 441.0
30.0, 30.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p16

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
911.0, 1035.0
34.0, 34.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23 p44

p61

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
561.0, 575.0
31.5, 31.5

TLR8: TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
554.0, 684.0
30.0, 30.0

TLR9: TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
554.0, 494.0
28.0, 28.0

TLR7 : TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p64

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1573.0, 1845.0
30.0, 30.0

XAF1

--

MO000060628

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p151

true true true true

csml-variable:Double

m35529

10

false

infinite

0

unit false false false
TRANSPATHMO000060628

--

Go back
532.0, 2024.0
31.0, 31.0

RNASEL

--

MO000061281

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p118

true true true true

csml-variable:Double

m36179

10

false

infinite

0

unit false false false
TRANSPATHMO000061281

--

Go back
1435.0, 2195.0
26.0, 26.0

CD69

--

MO000063455

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p145

true true true true

csml-variable:Double

m38334

10

false

infinite

0

unit false false false
TRANSPATHMO000063455

--

Go back
854.0, 370.0
27.5, 27.5

RIG-1 {activated}

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

p122

p6 p63

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
1514.0, 2018.0
28.0, 28.0

GBP1

--

MO000068682

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p158

true true true true

csml-variable:Double

m43527

10

false

infinite

0

unit false false false
TRANSPATHMO000068682

--

Go back
963.0, 375.0
26.0, 26.0

Mda-5 {activated}

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

p123

p7

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
422.45820204061283, 263.8659536605148
1305.3835481439526, 1895.416911905018

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
520.8429248238378, 524.7861769755982
1108.9766077913152, 1560.0182600518451

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1662.875, 431.5
29.606395668930077, 41.311249770600114

IFNAR1: IFNAR2: JAK1: TYK2

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p70 p71 p72 p73 p74 p75 p76 p77 p111

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1668.875, 289.5
26.023719948614424, 36.31216737015966

IFNAR1: IFNAR2: JAK1: TYK2: IFNalpha

--

e101

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p70

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1664.875, 332.5
27.238988805285373, 38.00789135621215

IFNAR1: IFNAR2: JAK1: TYK2: IFNbeta

--

e102

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p71

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1664.875, 381.5
26.35515690952468, 36.77463754817398

IFNAR1: IFNAR2: JAK1: TYK2: IFNomega

--

e103

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p72

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1659.875, 484.5
28.114929344833914, 39.23013396953569

IFNkappa: IFNAR1: IFNAR2: JAK1: TYK2

--

e104

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p73

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1658.875, 535.5
29.874701780143145, 41.685630390897416

IFNepsilon: IFNAR1: IFNAR2: JAK1: TYK2

--

e105

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p74

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1661.875, 587.5
24.192925307395853, 33.757570196366316

IFNtheta: IFNAR1: IFNAR2: JAK1: TYK2

--

e106

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p75

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1661.875, 630.5
24.80845109194347, 34.61644338410718

IFNtau: IFNAR1: IFNAR2: JAK1: TYK2

--

e107

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p76

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1482.5, 315.0
30.389612772985867, 42.40411084602679

IFN Type I: IFNAR1: IFNAR2: JAK1: TYK2

--

e108

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p77

p80 p94

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
1657.875, 913.5
32.25, 45.0

2IFNGR1: 2IFNGR2: 2JAK2: 2JAK1

--

e109

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p78 p113

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
560.0, 436.48252517398976
238.4927844044524, 398.1616824379416

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
1659.875, 973.5
32.25, 45.0

IFNgamma: IFNgamma: 2IFNGR1: 2IFNGR2: 2JAK2: 2JAK1

--

e110

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p78

p86

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1743.5, 692.125
31.790098611390626, 19.603894143690887

IFNlambda

--

e111

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p79

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
1662.875, 747.5
29.606395668930077, 41.311249770600114

IFNlambda: IFNLR1: IL10R2: JAK1: Tyk2

--

e112

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p79

p81

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
1293.875, 413.5
32.25, 45.0

STAT1: STAT2: IRF9

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p83 p85

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
1664.875, 697.5
26.22100385391815, 36.58744723802533

IFNLR1: IL10R2: JAK1: Tyk2

--

e114

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p79 p112

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
1421.875, 265.5
32.25, 45.0

IFN Type I: IFNAR1: IFNAR2: JAK1 {p}: TYK2

--

e115

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p80

p82

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
1001.5, 1482.0
37.78546712802768, 20.1522491349481

TNFSF10

--

e116

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p97

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
1358.875, 253.5
37.8686456230501, 52.839970636814094

IFN Type I: IFNAR1{p}: IFNAR2 {p}: JAK1 {p}: TYK2

--

e117

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p82

p83

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
1661.875, 801.5
32.25, 45.0

IFNlambda: IFNLR1: IL10R2: JAK1 {p}: Tyk2

--

e118

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p81

p84

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
1663.875, 857.5
32.25, 45.0

IFNlambda: IFNLR1 {p}: IL10R2 {p}: JAK1 {p}: Tyk2

--

e119

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p84

p85

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
461.5, 880.0
30.709715047492086, 37.6037327112148

TLR1: TLR2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1656.875, 1029.5
37.789732060928614, 52.72985868966783

IFNgamma: IFNgamma: 2IFNGR1: 2IFNGR2: 2JAK2 {p}: 2JAK1 [p}

--

e120

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p86

p87

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
1654.875, 1088.5
38.87873921820517, 54.24940356028629

IFNgamma: IFNgamma: 2IFNGR1 {p}: 2IFNGR2 {p}: 2JAK2 {p}: 2JAK1 [p}

--

e121

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p87

p88

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
1279.875, 473.5
32.25, 45.0

STAT1 [p}: STAT2 {p}: IRF9

--

e122

cso30:c:Complex

cso30:i:CC_Cytosol

--

p83 p85

p138

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
1653.875, 1150.5
48.14319141126812, 67.17654615525784

IFNgamma: IFNgamma: 2IFNGR1 {p}: 2IFNGR2 {p}: 2JAK2 {p}: 2JAK1 [p}: STAT1: STAT3

--

e123

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p88

p89

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
1650.875, 1219.5
46.39920168838319, 64.74307212332538

IFNgamma: IFNgamma: 2IFNGR1 {p}: 2IFNGR2 {p}: 2JAK2 {p}: 2JAK1 [p}: STAT1 [p}: STAT3 {p}

--

e124

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p89

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
1661.875, 1324.5
28.114929344833914, 39.23013396953569

IFNAR1: IFNAR2: JAK1: TYK2: PI3K

--

e125

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p90

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
1655.875, 1361.5
32.25, 45.0

IFNAR1: IFNAR2: JAK1: TYK2: PI3K: IFN Type I

--

e126

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p90

p91

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
1044.5, 1441.0
39.550173010380625, 21.093425605536332

CXCL11

--

e127

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p92 p95

--

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
1435.0, 1371.0
26.0, 26.0

STAT3 {activated}

--

e128

cso30:c:Protein

cso30:i:CC_CellComponent

--

p114

--

true true true true

csml-variable:Double

m133

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
1320.0, 1172.0
32.0, 32.0

PI3K {activated}

--

e129

cso30:c:Protein

cso30:i:CC_CellComponent

--

p99 p110

p100 p105

true true true true

csml-variable:Double

m134

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
463.5, 970.0
27.149641726378935, 33.244459256790535

TLR6: TLR2

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1109.028611544462, 413.9422932917313
7.3068230653754025, 13.152281517675686

--

e130

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false true false

--

Go back
1112.0226268492984, 422.42533665543556
1.1405772589854262, 1.1405772589854255

--

e131

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false true false

--

Go back
1242.5, 1295.125
35.56, 26.669999999999995

NF-kappaB {p}

--

e132

cso30:c:Protein

cso30:i:CC_Cytosol

--

p105

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
1327.0, 1950.0
32.0, 32.0

ERK {activated}

--

e133

cso30:c:Protein

cso30:i:CC_CellComponent

--

p106

p107

true true true true

csml-variable:Double

m141

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1389.5, 2032.125
35.72, 26.789999999999996

AP-1 {p}

--

e134

cso30:c:Protein

cso30:i:CC_Cytosol

--

p107

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
539.5, 1307.125
34.120000000000005, 25.590000000000007

PU.1{p}

--

e135

cso30:c:Protein

cso30:i:CC_Cytosol

--

p109

--

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
1326.625, 1251.5
27.408890184969174, 33.56190634894185

STAT3: NF-kappaB

--

e136

cso30:c:Complex

cso30:i:CC_Cytosol

--

p115

--

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
605.5, 1903.0
21.415174079291607, 34.72730931777018

OASs [actiavted}

--

e137

cso30:c:Protein

cso30:i:CC_Cytosol

--

p116

p117

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
529.5, 1847.0
21.415174079291607, 34.72730931777018

OASs

--

e138

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p116

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
527.5, 1947.625
38.550863723608444, 21.202975047984644

ATP

--

e139

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p117

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
293.0, 1015.5
39.25988225399496, 22.247266610597137

Lipoteichoic acid

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
523.5, 1983.25
45.0, 25.5

2'-to-5' linked oligoadenylate of 3?6 bases

--

e140

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p117

p118

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
675.625, 2020.5
31.769163472754542, 38.90101649725046

2-5A: RNASEL

--

e141

cso30:c:Complex

cso30:i:CC_Cytosol

--

p118

p119

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
676.875, 1895.5
29.472242613323544, 41.12405946045146

2-5A: RNASEL: RNASEL

--

e142

cso30:c:Complex

cso30:i:CC_Cytosol

--

p119

p120 p121

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
733.5, 1895.625
45.0, 24.75

ssRNA

--

e143

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p120

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false false false

--

Go back
789.5, 2007.25
45.0, 25.5

RNA degradation products

--

e144

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p120

p122 p123

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false false false

--

Go back
854.0, 1970.0
27.5, 27.5

RIG-1

--

e145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p122

true true true true

csml-variable:Double

m153

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
887.0, 1947.0
26.0, 26.0

Mda-5

--

e146

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p123

true true true true

csml-variable:Double

m154

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
843.0, 1851.0
26.5, 26.5

PKR {activated}

--

e147

cso30:c:Protein

cso30:i:CC_CellComponent

--

p128 p129

p130

true true true true

csml-variable:Double

m155

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
937.5, 2033.625
37.16890595009597, 20.442898272552785

GDP

--

e148

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p131

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false false false

--

Go back
935.5, 1903.125
33.96, 25.47

eIF-2alpha {p}

--

e149

cso30:c:Protein

cso30:i:CC_Cytosol

--

p130

p131

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false false false

--

Go back
463.25, 923.0
28.278674986236005, 39.45861625986419

Lp: TLR1: TLR2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1000.625, 1952.5
31.099608398600232, 38.08115314114314

: EIF2B

--

e150

cso30:c:Complex

cso30:i:CC_Cytosol

--

p131

--

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false false false

--

Go back
1003.0, 2023.0
26.0, 26.0

EIF2B1

--

e151

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p131

true true true true

csml-variable:Double

m159

10

false

infinite

0

unit false false false
TRANSPATHMO000070494

--

Go back
1060.0, 1988.0
32.0, 32.0

eIF3

--

e152

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p132 p133

true true true true

csml-variable:Double

m160

10

false

infinite

0

unit false false false
TRANSPATHMO000058067

--

Go back
1032.625, 1853.5
29.8993084485919, 36.61139810031661

p56: eIF3

--

e153

cso30:c:Complex

cso30:i:CC_Cytosol

--

p132

p134

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false false false

--

Go back
1122.625, 1967.5
26.478045325779036, 32.42209631728045

p54: eIF3

--

e154

cso30:c:Complex

cso30:i:CC_Cytosol

--

p133

--

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false false false

--

Go back
1062.5, 2039.125
27.66049506943048, 17.057305292815453

p54

--

e155

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p133

true true true true

csml-variable:Double

m163

0

false

infinite

0

unit false false false

--

Go back
948.5, 1754.0
38.46020761245675, 20.512110726643602

HCV mRNA

--

e156

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p134

true true true true

csml-variable:Double

m164

0

false

infinite

0

unit false false false

--

Go back
1136.5, 388.125
31.240000000000006, 23.429999999999996

GIP3

--

e157

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p136

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false false false

--

Go back
982.0, 1646.0
28.0, 28.0

Icam1

--

e158

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p139 p140 p141

--

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
Affymetrix110312_at
EnsemblENSMUSG00000037405
MGDIcam1
ProteomeHumanPSD/Icam1
RefSeqNM_010493
TRANSFACG005278
UnigeneMm.25455

--

Go back
1320.5, 2194.125
31.850472932179507, 19.64112497484403

IFN

--

e159

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p141 p143 p156 p157

true true true true

csml-variable:Double

m167

0

false

infinite

0

unit false false false

--

Go back
462.25, 1009.0
27.386951734263164, 38.21435125711139

Lipoteichoic acid: TLR6: TLR2

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1133.5, 1490.0
36.22837370242215, 19.32179930795848

CIITA

--

e160

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p144

--

true true true true

csml-variable:Double

m168

0

false

infinite

0

unit false false false

--

Go back
1435.375, 2096.5
24.86335676625659, 38.251318101933215

S1PR

--

e161

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p145

true true true true

csml-variable:Double

m169

0

false

infinite

0

unit false false false

--

Go back
1369.625, 2089.5
36.75, 45.0

cd69: S1PR

--

e162

cso30:c:Complex

cso30:i:CC_Cytosol

--

p145

--

true true true true

csml-variable:Double

m170

0

false

infinite

0

unit false false false

--

Go back
1103.0, 1535.0
26.0, 26.0

Mmp9

--

e163

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p146

--

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
Affymetrix102492_f_at
EnsemblENSMUSG00000017737
MGDMmp9
ProteomeHumanPSD/Mmp9
RefSeqNM_013599
TRANSFACG037540
UnigeneMm.391876

--

Go back
1071.0, 1555.0
25.0, 25.0

FAS

--

e164

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p149

--

true true true true

csml-variable:Double

m172

10

false

infinite

0

unit false false false
ProteomeHumanPSD/Fasn
RGDFasn
RefSeqNM_017332
TRANSFACG001019
UnigeneRn.13960

--

Go back
1175.5, 1463.0
33.99653979238755, 18.13148788927336

APO2L

--

e165

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p98

true true true true

csml-variable:Double

m173

0

false

infinite

0

unit false false false

--

Go back
1515.875, 1725.5
32.25, 45.0

XIAP: p53: XAF1

--

e166

cso30:c:Complex

cso30:i:CC_Cytosol

--

p151

p150 p152

true true true true

csml-variable:Double

m174

0

false

infinite

0

unit false false false

--

Go back
1349.5, 1736.125
37.69470718454418, 23.245069430468906

caspase

--

e167

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p152

true true true true

csml-variable:Double

m175

0

false

infinite

0

unit false false false

--

Go back
1345.5, 1805.125
36.36647212718857, 22.425991145099616

caspase {activated}

--

e168

cso30:c:Protein

cso30:i:CC_Cytosol

--

p152

--

true true true true

csml-variable:Double

m176

0

false

infinite

0

unit false false false

--

Go back
1509.5, 1893.125
36.36647212718857, 22.425991145099616

tumour-associated antigens

--

e169

cso30:c:Protein

cso30:i:CC_Cytosol

--

p153

--

true true true true

csml-variable:Double

m177

0

false

infinite

0

unit false false false

--

Go back
467.75, 1051.0
28.574487585402427, 34.98916847192134

TLR4: TLR4

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p4

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1512.5, 1935.125
30.341114912457236, 18.710354196015295

carcinoembryonic antigen

--

e170

cso30:c:Protein

cso30:i:CC_Cytosol

--

p154

--

true true true true

csml-variable:Double

m178

0

false

infinite

0

unit false false false

--

Go back
1508.5, 1972.125
36.53552022539747, 22.530237472328437

TAG72

--

e171

cso30:c:Protein

cso30:i:CC_Cytosol

--

p155

--

true true true true

csml-variable:Double

m179

0

false

infinite

0

unit false false false

--

Go back
1526.5, 1419.125
34.92, 26.189999999999998

PKC {p}

--

e172

cso30:c:Protein

cso30:i:CC_Cytosol

--

p101

p102

true true true true

csml-variable:Double

m180

0

false

infinite

0

unit false false false

--

Go back
1077.5073166926677, 356.8823166926678
84.39987519500724, 117.85104524180893

--

e173

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m181

0

false

infinite

0

unit false true false

--

Go back
1077.5073166926677, 356.8823166926678
84.39987519500724, 117.85104524180893

--

e174

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m182

0

false

infinite

0

unit false true false

--

Go back
1087.799984399376, 365.75974258970336
63.814539781590874, 100.09619344773725

--

e175

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m184

0

false

infinite

0

unit false true false

--

Go back
1077.5073166926677, 356.8823166926678
84.39987519500724, 117.85104524180893

--

e176

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m185

0

false

infinite

0

unit false true false

--

Go back
1088.057301092044, 366.0170592823712
63.29990639625551, 99.58156006240179

--

e177

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m186

0

false

infinite

0

unit false true false

--

Go back
1077.25, 356.625
84.91450858034263, 118.36567862714428

--

e178

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m187

0

false

infinite

0

unit false true false

--

Go back
1088.057301092044, 366.0170592823712
63.29990639625551, 99.58156006240179

--

e179

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m188

0

false

infinite

0

unit false true false

--

Go back
464.25, 1089.0
25.287850981831525, 35.28537346302074

LPS: TLR4: TLR4

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p59 p66 p69

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
455.75, 1371.0
28.011081486418927, 34.29928345275788

flagellin: TLR5

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
422.45820204061283, 263.8659536605148
1305.3835481439526, 1895.416911905018

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
302.0, 584.75
38.829174664107484, 21.356046065259115

ssRNA

--

e20

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p13 p14

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
911.75, 411.0
26.410681553074486, 32.339610064989174

dsRNA: RIG-1 {activated}

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p12 p125 p126

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1011.75, 401.0
24.989918346942176, 30.599900016663888

dsRNA: Mda-5 {activated}

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p11 p124 p127

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
279.0, 1470.25
30.0, 19.5

TLR ligand

--

e23

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
457.75, 1465.0
24.5, 30.0

TLR ligand: TLR

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
763.0, 1530.0
38.30449826989619, 20.429065743944633

IFN

--

e25

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p9 p60 p65

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1094.5, 358.0
15.882132834424697, 36.651075771749305

IPS-1

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11 p12 p62

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
956.25, 497.0
27.46586529638466, 38.32446320425767

dsRNA: RIG-1{activated}: IPS-1

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p41 p45 p50 p57

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1026.25, 553.0
27.663149201688384, 38.599743072123324

dsRNA: Mda-5 {activated}: IPS-1

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p42 p46 p51 p58

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
293.0, 690.75
47.32739420935412, 16.56458797327394

CpG DNA

--

e29

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
448.56587300349173, 289.9736246233938
1253.1682062181956, 1843.2015699792626

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
560.25, 733.0
25.564048449256745, 35.67076527803267

CpG DNA: TLR9: TLR9

--

e30

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p15

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
560.25, 621.0
25.63507065516609, 35.76986603046431

ssRNA: TLR8: TLR8

--

e31

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p14

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
554.25, 528.0
28.894200770783634, 40.317489447605055

ssRNA: TLR7 : TLR7

--

e32

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p13

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
762.0, 451.75
30.0, 22.5

Ptk

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
658.5, 413.0
27.674986236006607, 38.61625986419526

dsRNA:TLR3 {p}

--

e34

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p16

p17

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
705.5, 428.0
28.322077445402826, 39.51917783079464

dsRNA:TLR3: TLR3 {p}

--

e35

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p17

p18 p22 p67 p68

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
776.875, 521.5
25.195127546338774, 35.15599192512388

dsRNA:TLR3: TLR3 {p}: CD14

--

e36

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p18

p10

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
786.875, 614.5
28.927739034685263, 40.36428702514223

dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p21

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
720.875, 760.5
32.25, 45.0

dsRNA:TLR3: TLR3 {p}: PI3K

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p161

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
775.875, 665.5
41.57758304276013, 58.01523215268857

dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i: IRF-3

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p20

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
496.8650642848186, 335.66204880843173
1156.5698236555431, 1751.8247216091834

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
753.875, 720.5
37.797623417140755, 52.740869884382455

dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i: IRF-3 {p}

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p38

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
855.0, 831.0
34.0, 34.0

IRF-3{p}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p23

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
592.875, 808.5
32.25, 45.0

dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF6: TAK1

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25 p28 p29

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
688.0, 944.0
32.0, 32.0

IKK {activated}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25 p49 p56 p160

p26

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
537.0, 1120.0
28.0, 28.0

ATF2

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSFACT10236
TRANSPATHMO000057404

--

Go back
587.0, 1209.0
28.0, 28.0

ATF2 {activated}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p34

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSFACT10236
TRANSPATHMO000057404

--

Go back
587.0, 1061.0
28.0, 28.0

JNK {activated}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28 p47

p30

true true true true

csml-variable:Double

m48

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
794.0, 1192.0
23.0, 23.0

p38 {activated}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29 p48 p94 p103 p108

p31 p96 p104 p109

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
703.0, 1249.0
29.0, 29.0

c-Jun {activated}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p33

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
779.0, 1361.0
29.0, 29.0

c-Jun {nucleus}

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

p36

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
560.0, 436.48252517398976
238.4927844044524, 398.1616824379416

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
656.6074147023753, 1259.3966621502746
586.1390183106984, 531.5636907212482

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
719.9147947061376, 1271.9939488483133
342.73305726174937, 515.1910924444131

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
664.2479605648984, 1266.491454736903
570.8579265856528, 517.374105547991

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
665.3394671166875, 1267.5829612886923
568.6749134820744, 515.1910924444131

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
656.6074147023753, 1259.3966621502746
586.1390183106984, 531.5636907212482

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
656.6074147023753, 1259.3966621502746
586.1390183106984, 531.5636907212482

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
665.3394671166875, 1267.5829612886923
568.6749134820744, 515.1910924444131

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1084.4779830036673, 1477.6979725080769
36.61874532082848, 33.14960102727635

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
988.4254064462343, 1630.5088897585379
103.69312241995594, 93.86956345385497

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
656.6074147023753, 1259.3966621502746
586.1390183106984, 531.5636907212482

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
560.0, 436.48252517398976
238.4927844044524, 398.1616824379416

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
794.7570833409559, 1495.619173959861
18.56216146908048, 8.93733700363135

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
794.1372402277907, 1468.965920093764
63.533919099416906, 114.36105437895037

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
820.7904940938879, 1543.3470936735694
9.917489810640674, 9.917489810640676

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
748.0, 1398.0
28.0, 28.0

ATF2 {nucleus}

--

e63

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p37

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSFACT10236
TRANSPATHMO000057404

--

Go back
905.0, 1335.0
34.0, 34.0

p50:RelA-p65 {nucleus}

--

e64

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p35

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
903.5, 1481.625
45.0, 12.75

p50: RelA-p65: target genes

--

e65

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p35

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
831.5, 1465.625
45.0, 12.75

c-Jun: target genes

--

e66

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p36

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
827.5, 1513.625
45.0, 12.75

ATF2: target genes

--

e67

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
679.875, 785.5
32.25, 45.0

dsRNA:TLR3: TLR3 {p}: CD14: TRIF: TRAF3: TBK1: IKK-i

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
953.0, 1319.0
34.0, 34.0

IRF-3: IRF-3{p} {nucleus}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

p40

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
436.61918765410155, 270.16361710103445
1057.0058433486956, 1497.7499772911412

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
947.5, 1449.625
45.0, 12.75

IRF3{p}: target genes

--

e70

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1065.0, 704.0
27.0, 27.0

TRAF3 {activated}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41 p42

p43

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1023.0, 785.0
30.0, 30.0

IKK-i

--

e72

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

p44

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1130.625, 628.5
31.099608398600232, 38.08115314114314

TRAF6: TAK1

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p45 p46

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1090.625, 828.5
31.099608398600232, 38.08115314114314

TRAF6: TAK1 {activated}

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45 p46

p47 p48 p49

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1163.875, 444.5
26.284134703615344, 36.67553679574234

dsRNA: RIG-1 {activated}: IPS-1: FADD

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p53 p55

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1169.875, 541.5
32.25, 45.0

dsRNA: Mda-5 {activated}: IPS-1: FADD

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p54 p52

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1028.0, 930.0
28.0, 28.0

Caspase-10 [activated}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53 p52

p56

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000016906

--

Go back
1033.0, 1019.0
34.0, 34.0

Caspase-8 {activated}

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54 p55

p160

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
1004.0, 714.0
28.0, 28.0

TBK1 {activated}

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57 p58

p43

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
440.39545048436514, 296.59745691288003
1013.9983005633133, 1472.3255324179315

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
449.875, 1501.5
32.25, 45.0

LPS: TLR4: TLR4: TRIF

--

e80

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p59

p60

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
949.5, 1198.125
36.84, 27.630000000000003

IRF-3: IRF-3 {p}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p61

p39

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1107.125, 204.5
18.568877037633325, 30.111692493459444

HCV protease

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11 p12 p62

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
765.125, 410.5
21.45798953511773, 34.7967397866774

NS1

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p63

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
635.4654846984016, 355.0312967247255
1009.3688421082995, 1453.016351991666

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
906.625, 449.5
30.029953341109817, 36.77137143809365

NS1: RIG-1 {activated}

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p12

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
297.5, 463.25
45.0, 25.5

quinolinamine imiquimod

--

e91

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p64

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
559.875, 459.5
24.327078363002386, 33.94476050651495

quinolinamine imiquimod: TLR7: TLR7

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
335.5, 1543.25
45.0, 25.5

DMXAA

--

e93

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p65

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
787.0, 1617.0
30.0, 30.0

IFN-alpha1

--

e94

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p68 p69

--

true true true true

csml-variable:Double

m98

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
1788.0, 294.0
28.0, 28.0

IFNalpha

--

e95

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70 p149

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
1789.5, 494.125
33.021734755484005, 20.363403099215134

IFNkappa

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p73

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1789.5, 546.125
33.021734755484005, 20.363403099215134

IFNepsilon

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p74

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1794.5, 594.125
31.95914670959952, 19.7081404709197

IFNtheta

--

e98

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p75

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1794.5, 638.125
31.681424833970613, 19.53687864761521

IFNtau

--

e99

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p76

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
376.0, 930.0
26.0, 26.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017793 e12

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c6 : 1
stoichiometry:c2 : 1

m2549*m12*0.1

nodelay

--

true

0

false

PMID: 18049472 It was also shown that microbial nucleic acids, lipids, polysaccharides or proteins trigger induction of IFNs through activation of TLRs.

Go back
833.0, 523.0
23.0, 23.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e36

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c53 : 1
stoichiometry:c29 : 1

m18998*m36*0.1

nodelay

--

true

0

false

PMID: 18049472 TLR3 dimerizes, binds to CD14 and activates the signalling complex assembled by TLR adaptor molecule 1 (TRIF).

Go back
1571.0, 1227.0
25.0, 25.0

p100

p100

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000048 e129

MO000019343

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c277 : 1
stoichiometry:c276 : 1

m131*m134*0.1

nodelay

--

true

0

false

PMID: 18049472, 17969446 Serine 727 of STAT1 is phosphorylated in response to IFN-gamma by the kinase cascade PI3K¡½AKT¡½PKC¡½MKK4¡½p38 (MKK4, mitogen-activated protein kinase kinase 4; also known as MAP2K4), with some variation in the activation of different PKC or MKK proteins in different cells.

Go back
1595.0, 1375.0
25.0, 25.0

p101

p101

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000104 MO000019343

e172

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c278 : 1
stoichiometry:c279 : 1
stoichiometry:c281 : 1

m135*m3914*0.1

nodelay

--

true

0

false

PMID: 18049472, 17969446 Serine 727 of STAT1 is phosphorylated in response to IFN-gamma by the kinase cascade PI3K¡½AKT¡½PKC¡½MKK4¡½p38 (MKK4, mitogen-activated protein kinase kinase 4; also known as MAP2K4), with some variation in the activation of different PKC or MKK proteins in different cells.

Go back
1587.0, 1475.0
25.0, 25.0

p102

p102

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016917 e172

MO000038341

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c280 : 1
stoichiometry:c282 : 1
stoichiometry:c286 : 1

m1832*m180*0.1

nodelay

--

true

0

false

PMID: 18049472, 17969446 Serine 727 of STAT1 is phosphorylated in response to IFN-gamma by the kinase cascade PI3K¡½AKT¡½PKC¡½MKK4¡½p38 (MKK4, mitogen-activated protein kinase kinase 4; also known as MAP2K4), with some variation in the activation of different PKC or MKK proteins in different cells.

Go back
813.0, 1147.0
26.0, 26.0

p103

p103

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 MO000038341

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c284 : 1
stoichiometry:c283 : 1
stoichiometry:c285 : 1

m49*m16555*0.1

nodelay

--

true

0

false

PMID: 18049472, 17969446 Serine 727 of STAT1 is phosphorylated in response to IFN-gamma by the kinase cascade PI3K¡½AKT¡½PKC¡½MKK4¡½p38 (MKK4, mitogen-activated protein kinase kinase 4; also known as MAP2K4), with some variation in the activation of different PKC or MKK proteins in different cells.

Go back
1444.0, 1104.0
23.0, 23.0

p104

p104

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e47

MO000038375

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c287 : 1
stoichiometry:c289 : 1
stoichiometry:c288 : 1

m1357*m63*0.1

nodelay

--

true

0

false

PMID: 18049472, 17969446 Serine 727 of STAT1 is phosphorylated in response to IFN-gamma by the kinase cascade PI3K¡½AKT¡½PKC¡½MKK4¡½p38 (MKK4, mitogen-activated protein kinase kinase 4; also known as MAP2K4), with some variation in the activation of different PKC or MKK proteins in different cells.

Go back
1179.0, 1247.0
25.0, 25.0

p105

p105

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000058 e129

e132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c291 : 1
stoichiometry:c292 : 1

m138*m134*0.1

nodelay

--

true

0

false

PMID: 18049472 IFN-dependent activation of PI3K, extracellular response kinases (ERKs) and p38 stimulates the phosphorylation of NFkappaB (but not IkappaB), AP-1 and possibly PU.1, respectively.

Go back
1394.0, 1953.0
25.0, 25.0

p106

p106

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000011

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1

m140*0.1

nodelay

--

true

0

false

PMID: 18049472 IFN-dependent activation of PI3K, extracellular response kinases (ERKs) and p38 stimulates the phosphorylation of NFkappaB (but not IkappaB), AP-1 and possibly PU.1, respectively.

Go back
1399.0, 1990.0
23.0, 23.0

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e133 MO000000276

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c296 : 1
stoichiometry:c300 : 1
stoichiometry:c301 : 1

m141*m219*0.1

nodelay

--

true

0

false

PMID: 18049472 IFN-dependent activation of PI3K, extracellular response kinases (ERKs) and p38 stimulates the phosphorylation of NFkappaB (but not IkappaB), AP-1 and possibly PU.1, respectively.

Go back
792.0, 1246.0
27.0, 27.0

p108

p108

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c299 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18049472 IFN-dependent activation of PI3K, extracellular response kinases (ERKs) and p38 stimulates the phosphorylation of NFkappaB (but not IkappaB), AP-1 and possibly PU.1, respectively.

Go back
598.0, 1256.0
23.0, 23.0

p109

p109

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000037579 e47

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c302 : 1
stoichiometry:c304 : 1
stoichiometry:c303 : 1

m15836*m63*0.1

nodelay

--

true

0

false

PMID: 18049472 IFN-dependent activation of PI3K, extracellular response kinases (ERKs) and p38 stimulates the phosphorylation of NFkappaB (but not IkappaB), AP-1 and possibly PU.1, respectively.

Go back
1026.0, 472.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 e26 e88

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c179 : 1
stoichiometry:c35 : 1

m22*m26*0.1

nodelay

--

true

0

false

PMID: 18049472 The cytoplasmic RNA helicases RIG-I and MDA5 recognize dsRNA or 5' triphosphorylated single-stranded (ss) RNA and use the mitochondrial membrane-bound protein IFN-beta-promoter stimulator 1 (IPS1; also known as VISA) as the specific adaptor. PMID: 18049472, 15710892 For example, a hepatitis C virus (HCV)-encoded protease can cleave IPS1 off the mitochondrial membrane and block RIG-I/MDA5-mediated signalling.

Go back
1295.0, 1091.0
25.0, 25.0

p110

p110

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c274 : 1
stoichiometry:c295 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 18049472 IFN-dependent activation of PI3K, extracellular response kinases (ERKs) and p38 stimulates the phosphorylation of NFkappaB (but not IkappaB), AP-1 and possibly PU.1, respectively.

Go back
1544.0, 438.0
27.0, 27.0

p111

p111

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytoplasm

--

MO000017115 e100

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c310 : 1
stoichiometry:c307 : 1

m2002*m104*0.1

nodelay

--

true

0

false

PMID: 18049472, 15032587 SOCS inhibit receptor signalling both by directly inhibiting JAKs and by targeting the receptor complex for proteasomal degradation.

Go back
1560.0, 702.0
27.0, 27.0

p112

p112

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000017115 e114

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c305 : 1
stoichiometry:c311 : 1
stoichiometry:c308 : 1

m2002*m118*0.1

nodelay

--

true

0

false

PMID: 18049472, 15032587 SOCS inhibit receptor signalling both by directly inhibiting JAKs and by targeting the receptor complex for proteasomal degradation.

Go back
1560.0, 922.0
27.0, 27.0

p113

p113

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000017115 e109

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c306 : 1
stoichiometry:c312 : 1
stoichiometry:c309 : 1

m2002*m113*0.1

nodelay

--

true

0

false

PMID: 18049472, 15032587 SOCS inhibit receptor signalling both by directly inhibiting JAKs and by targeting the receptor complex for proteasomal degradation.

Go back
1435.0, 1435.0
25.0, 25.0

p114

p114

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013122 MO000007384

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c315 : 1
stoichiometry:c314 : 1

m1360*m871*0.1

nodelay

--

true

0

false

PMID: 18049472 STAT1 is activated in response to both type I and type II IFNs and STAT3 is activated in response to gp130 cytokines such as IL6.

Go back
1527.0, 1167.0
25.0, 25.0

p115

p115

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000058 MO000013122

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c316 : 1
stoichiometry:c317 : 1
stoichiometry:c318 : 1

m138*m1360*0.1

nodelay

--

true

0

false

PMID: 18049472, 17510282 For example, unphosphorylated STAT3 activates a subset of kappaB-dependent genes by forming a complex with NFkappaB.

Go back
527.0, 1907.0
25.0, 25.0

p116

p116

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e138 MO000022224

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c321 : 1
stoichiometry:c320 : 1

m146*m119368*0.1

nodelay

--

true

0

false

PMID: 18049472, 272640 Viral dsRNA can directly activate one of several human OAS proteins to produce a unique 2'-to-5' linked oligoadenylate of 3?6 bases (2?5A) from ATP.

Go back
602.0, 1984.0
23.0, 23.0

p117

p117

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e137 e139

e140

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c323 : 1
stoichiometry:c324 : 1

m145*m147*0.1

nodelay

--

true

0

false

PMID: 18049472, 272640 Viral dsRNA can directly activate one of several human OAS proteins to produce a unique 2'-to-5' linked oligoadenylate of 3?6 bases (2?5A) from ATP.

Go back
603.0, 2027.0
25.0, 25.0

p118

p118

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e140 MO000061281

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c325 : 1
stoichiometry:c326 : 1
stoichiometry:c327 : 1

m148*m36179*0.1

nodelay

--

true

0

false

PMID: 18049472, 7876164, 6162102, 6165080 2?5A binding to RNASEL induces monomeric, inactive RNASEL to dimerize into a potent endoribonuclease that cleaves single-stranded regions of RNA on the 3' side of UpUp and UpAp dinucleotides.

Go back
677.0, 1963.0
25.0, 25.0

p119

p119

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e141

e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c328 : 1
stoichiometry:c329 : 1

m149*0.1

nodelay

--

true

0

false

PMID: 18049472, 7876164, 6162102, 6165080 2?5A binding to RNASEL induces monomeric, inactive RNASEL to dimerize into a potent endoribonuclease that cleaves single-stranded regions of RNA on the 3' side of UpUp and UpAp dinucleotides. PMID: 18049472, 7680958 The only well-established function of 2?5A is activation of the ubiquitous, latent enzyme, RNASEL.

Go back
958.0, 460.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e26 e88 e90

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c178 : 1
stoichiometry:c183 : 1
stoichiometry:c32 : 1

m21*m26*0.1

nodelay

--

true

0

false

PMID: 18049472 The cytoplasmic RNA helicases RIG-I and MDA5 recognize dsRNA or 5' triphosphorylated single-stranded (ss) RNA and use the mitochondrial membrane-bound protein IFN-beta-promoter stimulator 1 (IPS1; also known as VISA) as the specific adaptor. PMID: 18049472, 15710892 For example, a hepatitis C virus (HCV)-encoded protease can cleave IPS1 off the mitochondrial membrane and block RIG-I/MDA5-mediated signalling. PMID: 18049472, 17038589 NS1 protein of influenza viruses prevents establishment of an antiviral state through the interaction with RIG-I.

Go back
742.0, 1960.0
31.0, 31.0

p120

p120

cso30:i:ME_MRNACleavage

cso30:i:CC_Cytosol

--

e143 e142

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c330 : 1
stoichiometry:c331 : 1
stoichiometry:c333 : 1

m151*m150*0.1

nodelay

--

true

0

false

PMID: 18049472, 7876164, 6162102, 6165080 2?5A binding to RNASEL induces monomeric, inactive RNASEL to dimerize into a potent endoribonuclease that cleaves single-stranded regions of RNA on the 3' side of UpUp and UpAp dinucleotides. PMID: 18049472, 17804500 The OAS?RNASEL pathway can inhibit the replication of encephalomyocarditis virus, Coxsackie virus B4, West Nile virus, some retroviruses and HCV.

Go back
770.0, 2230.0
27.0, 27.0

p121

p121

cso30:i:CE_CellDeath

cso30:i:CC_Cytosol

--

e142

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c332 : 1

m150*0.1

nodelay

--

true

0

false

PMID: 18049472, 9351818, 10200477, 9294150 Furthermore, degradation of cellular mRNA and rRNA by RNASEL damages the host cell machinery that is required for viral replication and can result in apoptosis, contributing to both antiviral and antitumour actions.

Go back
854.0, 2038.0
27.0, 27.0

p122

p122

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e145 e144

MO000066987

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c334 : 1
stoichiometry:c335 : 1
stoichiometry:c336 : 1

m153*m152*0.1

nodelay

--

true

0

false

PMID: 18049472, 17653195 RNASEL also cleaves self-RNA into small degradation products that activate the recognition receptors, RIG-I and MDA5, to induce IFN-beta, similar to that of non-self viral RNA90, thus perpetuating and amplifying the production of IFN-beta.

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887.0, 2015.0
25.0, 25.0

p123

p123

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e146 e144

MO000103999

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1
stoichiometry:c339 : 1

m154*m152*0.1

nodelay

--

true

0

false

Go back
879.0, 1623.0
25.0, 25.0

p124

p124

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c348 : 1
stoichiometry:c340 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 18049472, 17653195 RNASEL also cleaves self-RNA into small degradation products that activate the recognition receptors, RIG-I and MDA5, to induce IFN-beta, similar to that of non-self viral RNA90, thus perpetuating and amplifying the production of IFN-beta.

Go back
859.0, 1646.0
23.0, 23.0

p125

p125

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c346 : 1
stoichiometry:c341 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18049472, 17653195 RNASEL also cleaves self-RNA into small degradation products that activate the recognition receptors, RIG-I and MDA5, to induce IFN-beta, similar to that of non-self viral RNA90, thus perpetuating and amplifying the production of IFN-beta.

Go back
1263.0, 1671.0
25.0, 25.0

p126

p126

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e21

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c343 : 1
stoichiometry:c347 : 1
stoichiometry:c345 : 1

m93217*m21*0.1

nodelay

--

true

0

false

PMID: 18049472, 17653195 RNASEL also cleaves self-RNA into small degradation products that activate the recognition receptors, RIG-I and MDA5, to induce IFN-beta, similar to that of non-self viral RNA90, thus perpetuating and amplifying the production of IFN-beta.

Go back
1287.0, 1647.0
25.0, 25.0

p127

p127

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e22

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c342 : 1
stoichiometry:c349 : 1
stoichiometry:c344 : 1

m93217*m22*0.1

nodelay

--

true

0

false

PMID: 18049472, 17653195 RNASEL also cleaves self-RNA into small degradation products that activate the recognition receptors, RIG-I and MDA5, to induce IFN-beta, similar to that of non-self viral RNA90, thus perpetuating and amplifying the production of IFN-beta.

Go back
787.0, 1807.0
25.0, 25.0

p128

p128

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

MO000008179 MO000022224

e147

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c350 : 1
stoichiometry:c352 : 1
stoichiometry:c351 : 1

m1055*m119368*0.1

nodelay

--

true

0

false

PMID: 18049472, 1004583, 283387 The dsRNA-activated protein kinase (PKR) and OAS were the first enzymes identified that uniquely respond to IFNs.

Go back
785.0, 1853.0
21.0, 21.0

p129

p129

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000008179 MO000022533

e147

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c353 : 1
stoichiometry:c355 : 1
stoichiometry:c354 : 1

m1055*m6814*0.1

nodelay

--

true

0

false

PMID: 18049472, 9687506 In addition, the cellular protein PACT (also known as PRKRA) activates PKR in the absence of dsRNA.

Go back
385.0, 535.0
23.0, 23.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e20 MO000042126

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m20*m19940*0.1

nodelay

--

true

0

false

PMID; 18049472, 17190786 Other nucleic acids such as ssRNA, acting through TLR7 and TLR8, and bacterial oligodeoxyribonucleotides, acting through TLR9, are also potent inducers. PMID: 18049472 They also function as dimers and recognize double-stranded (ds) RNA, single-stranded (ss) RNA or dsDNA containing CpG sequences. GPI, glycosylphosphatidylinisotol; LPS, lipopolysaccharide.

Go back
855.0, 1903.0
26.0, 26.0

p130

p130

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000022570 e147

e149

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c356 : 1
stoichiometry:c358 : 1
stoichiometry:c357 : 1

m6843*m155*0.1

nodelay

--

true

0

false

PMID: 18049472 PKR mediates translational control by phosphorylating the protein synthesis initiation factor EIF2alpha, resulting in an inactive complex between EIF2?GDP and the recycling factor, EIF2B.

Go back
943.0, 1959.0
25.0, 25.0

p131

p131

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e149 e148 e151

e150

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c359 : 1
stoichiometry:c360 : 1
stoichiometry:c362 : 1
stoichiometry:c361 : 1

m157*m156*m159*0.1

nodelay

--

true

0

false

PMID: 18049472 PKR mediates translational control by phosphorylating the protein synthesis initiation factor EIF2alpha, resulting in an inactive complex between EIF2?GDP and the recycling factor, EIF2B.

Go back
1064.0, 1932.0
23.0, 23.0

p132

p132

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000013291 e152

e153

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c363 : 1
stoichiometry:c364 : 1
stoichiometry:c365 : 1

m1377*m160*0.1

nodelay

--

true

0

false

PMID: 18049472 p56 and p54 bind to different subunits of EIF3 and block some of its diverse functions.

Go back
1123.0, 2027.0
25.0, 25.0

p133

p133

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e152 e155

e154

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c366 : 1
stoichiometry:c368 : 1
stoichiometry:c367 : 1

m160*m163*0.1

nodelay

--

true

0

false

PMID: 18049472 p56 and p54 bind to different subunits of EIF3 and block some of its diverse functions.

Go back
959.0, 1859.0
25.0, 25.0

p134

p134

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e153 e156

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c369 : 1
stoichiometry:c370 : 1

m164*0.1

nodelay

--

true

0

false

Go back
1774.0, 1494.0
27.0, 27.0

p135

p135

cso30:i:CE_CellDeath

cso30:i:CC_Cytosol

--

MO000017871

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c371 : 1

m2615*0.1

nodelay

--

true

0

false

PMID: 18048472, 10224285, 11410525, 11568006 TRAIL/APO2L is an ISG that contributes to apoptosis and therefore probably to both the antiviral and antitumour effects of IFNs.

Go back
1197.0, 177.0
30.0, 30.0

p136

p136

cso30:i:CE_CellDeathAnd/OrCellSurvival

cso30:i:CC_Cytoplasm

--

e157

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c372 : 1

m165*0.1

nodelay

--

true

0

false

PMID: 18049472, 15685448 Although many ISGs promote apoptosis, some promote cell survival. For example, the ISG G1P3 (or 6?16)116, 117 localizes to mitochondria and has anti-apoptotic actions, including inhibition of caspase-3.

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1499.0, 991.0
25.0, 25.0

p137

p137

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000016665

MO000017268

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c373 : 1
stoichiometry:c374 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 18049472, 17579067 MHC class II proteins are selectively upregulated by IFN-gamma, whereas type I IFNs fail to do so owing to the STAT2-dependent induction of SOCS1.

Go back
1100.0, 1324.0
23.0, 23.0

p138

p138

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e122

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c376 : 1
stoichiometry:c375 : 1

m126*0.1

nodelay

--

true

0

false

PMID: 18049472, 17579067 MHC class II proteins are selectively upregulated by IFN-gamma, whereas type I IFNs fail to do so owing to the STAT2-dependent induction of SOCS1.

Go back
996.0, 1740.0
24.0, 24.0

p139

p139

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000289

e158

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c377 : 1
stoichiometry:c382 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 18049472 IFNs also promote accumulation of leukocytes at sites of pathogen invasion; specifically, IFNs (along with cytokines such as TNFalpha and IL1beta), strongly promote the expression of vascular adhesion molecules including intracellular adhesion molecule 1 (ICAM1).

Go back
392.0, 626.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e20 MO000042007

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m20*m19823*0.1

nodelay

--

true

0

false

PMID; 18049472, 17190786 Other nucleic acids such as ssRNA, acting through TLR7 and TLR8, and bacterial oligodeoxyribonucleotides, acting through TLR9, are also potent inducers. PMID: 18049472 They also function as dimers and recognize double-stranded (ds) RNA, single-stranded (ss) RNA or dsDNA containing CpG sequences. GPI, glycosylphosphatidylinisotol; LPS, lipopolysaccharide.

Go back
1032.0, 1736.0
23.0, 23.0

p140

p140

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016597

e158

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c378 : 1
stoichiometry:c381 : 1

m1591*0.1

nodelay

--

true

0

false

PMID: 18049472 IFNs also promote accumulation of leukocytes at sites of pathogen invasion; specifically, IFNs (along with cytokines such as TNFalpha and IL1beta), strongly promote the expression of vascular adhesion molecules including intracellular adhesion molecule 1 (ICAM1).

Go back
1052.0, 1708.0
23.0, 23.0

p141

p141

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e159

e158

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c379 : 1
stoichiometry:c380 : 1

m167*0.1

nodelay

--

true

0

false

PMID: 18049472 IFNs also promote accumulation of leukocytes at sites of pathogen invasion; specifically, IFNs (along with cytokines such as TNFalpha and IL1beta), strongly promote the expression of vascular adhesion molecules including intracellular adhesion molecule 1 (ICAM1).

Go back
1093.0, 1461.0
21.0, 21.0

p142

p142

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016660

G012252

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c423 : 1
stoichiometry:c383 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes.

Go back
1088.0, 1652.0
23.0, 23.0

p143

p143

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e159

G011193

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c386 : 1
stoichiometry:c271 : 1

m167*0.1

nodelay

--

true

0

false

PMID: 18049472, 9625760, 2115167, 8798467 As examples, three closely related chemokines involved in accumulation of activated T cells and macrophages are the ISGs CXCL9 (also known as MIG, monokine induced by IFN-gamma); CXCL10 (also known as IP-10, IFN-gamma 10 kD inducible protein); and CXCL11 (also known as I-TAC, interferon-inducible T-cell alpha-chemoattractant)136, 137, 138, 139. True to their names, these chemokines are not expressed in the absence of IFN signalling.

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1188.0, 1512.0
23.0, 23.0

p144

p144

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

e160

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c387 : 1
stoichiometry:c385 : 1

m1639*0.1

nodelay

--

true

0

false

Go back
1376.0, 2196.0
24.0, 24.0

p145

p145

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000063455 e161

e162

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c390 : 1
stoichiometry:c392 : 1
stoichiometry:c391 : 1

m38334*m169*0.1

nodelay

--

true

0

false

PMID: 18049472 As one example, an IFN-beta ISG product, CD69, forms an inhibitory association with a sphingosine 1-phosphate receptor (S1PR).

Go back
1160.0, 1580.0
23.0, 23.0

p146

p146

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016660

e163

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c395 : 1
stoichiometry:c388 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18049472, 9153530, 9007090, 9007089 Reduction in expression of matrix metalloproteinase 9 (MMP9) in activated lymphocytes and increased soluble vascular cell adhesion molecule (sVCAM) levels in plasma have also been identified and assigned putative roles in the beneficial effects of IFN-beta for patients with MS.

Go back
1264.0, 1560.0
23.0, 23.0

p147

p147

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010430 MO000016660

MO000000308

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c393 : 1
stoichiometry:c394 : 1
stoichiometry:c389 : 1

m93402*m1636*0.1

nodelay

--

true

0

false

PMID: 18049472, 9153530, 9007090, 9007089 Reduction in expression of matrix metalloproteinase 9 (MMP9) in activated lymphocytes and increased soluble vascular cell adhesion molecule (sVCAM) levels in plasma have also been identified and assigned putative roles in the beneficial effects of IFN-beta for patients with MS.

Go back
1773.0, 1541.0
30.0, 30.0

p148

p148

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

MO000004927

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c396 : 1

m580*0.1

nodelay

--

true

0

false

PMID: 18049472, 12766484, 14977850 Induction of apoptosis by the ISG products APO2L/TRAIL and Fas has been identified in many malignant cell types, as has induction of APO2L/TRAIL on immune effector cell surfaces, thus sensitizing tumour cells to T-cell, NK cell and macrophage-mediated cytotoxicity.

Go back
1160.0, 1612.0
23.0, 23.0

p149

p149

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e95

e164

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c399 : 1
stoichiometry:c398 : 1

m99*0.1

nodelay

--

true

0

false

PMID: 18049472, 10417772, 12171874 Intralesional administration of IFN-alpha into basal cell carcinomas increased Fas expression and correlated with regression244. IFN-gamma has increased susceptibility to apoptosis by Fas activators and cytotoxic chemotherapies in many cell types including melanoma and colorectal carcinoma.

Go back
393.0, 687.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042012 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m19828*m29*0.1

nodelay

--

true

0

false

PMID; 18049472, 17190786 Other nucleic acids such as ssRNA, acting through TLR7 and TLR8, and bacterial oligodeoxyribonucleotides, acting through TLR9, are also potent inducers. PMID: 18049472 They also function as dimers and recognize double-stranded (ds) RNA, single-stranded (ss) RNA or dsDNA containing CpG sequences. GPI, glycosylphosphatidylinisotol; LPS, lipopolysaccharide.

Go back
1761.0, 1741.0
30.0, 30.0

p150

p150

cso30:i:CE_CellDeathAnd/OrCellSurvival

cso30:i:CC_Extracellular

--

e166

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c404 : 1

m174*0.1

nodelay

--

true

0

false

PMID: 18049472, 12029096, 16909101 Through interactions with p53 and the inhibitor of apoptosis, XIAP, the ISG product XAF1 may allow APO2L/TRAIL to fully activate downstream caspases.

Go back
1576.0, 1792.0
23.0, 23.0

p151

p151

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017876 MO000000277 MO000060628

e166

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c400 : 1
stoichiometry:c401 : 1
stoichiometry:c402 : 1
stoichiometry:c403 : 1

m2619*m220*m35529*0.1

nodelay

--

true

0

false

PMID: 18049472, 12029096, 16909101 Through interactions with p53 and the inhibitor of apoptosis, XIAP, the ISG product XAF1 may allow APO2L/TRAIL to fully activate downstream caspases.

Go back
1410.0, 1734.0
27.0, 27.0

p152

p152

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017871 e166 e167

e168

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c405 : 1
stoichiometry:c406 : 1
stoichiometry:c407 : 1
stoichiometry:c408 : 1

m2615*m174*m175*0.1

nodelay

--

true

0

false

PMID: 18049472, 12029096, 16909101 Through interactions with p53 and the inhibitor of apoptosis, XIAP, the ISG product XAF1 may allow APO2L/TRAIL to fully activate downstream caspases.

Go back
1580.0, 1892.0
23.0, 23.0

p153

p153

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000016665

e169

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c412 : 1
stoichiometry:c410 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 18049472, 1569446 In addition, IFN-gamma can upregulate the tumour-associated antigens, carcinoembryonic antigen and TAG72, both in vitro and in vivo.

Go back
1578.0, 1930.0
27.0, 27.0

p154

p154

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000016665

e170

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c413 : 1
stoichiometry:c409 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 18049472, 1569446 In addition, IFN-gamma can upregulate the tumour-associated antigens, carcinoembryonic antigen and TAG72, both in vitro and in vivo.

Go back
1579.0, 1967.0
25.0, 25.0

p155

p155

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000016665

e171

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c414 : 1
stoichiometry:c411 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 18049472, 1569446 In addition, IFN-gamma can upregulate the tumour-associated antigens, carcinoembryonic antigen and TAG72, both in vitro and in vivo.

Go back
1135.0, 1663.0
25.0, 25.0

p156

p156

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e159

G010711

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c418 : 1
stoichiometry:c415 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18049472, 12644537 IFNs also inhibit vascular endothelial growth factor (VEGF) mRNA and protein expression by regulating its promoter.

Go back
1219.0, 1683.0
25.0, 25.0

p157

p157

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010711 e159

MO000014520

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c417 : 1
stoichiometry:c419 : 1
stoichiometry:c416 : 1

m93629*0.1

nodelay

--

true

0

false

PMID: 18049472, 12644537 IFNs also inhibit vascular endothelial growth factor (VEGF) mRNA and protein expression by regulating its promoter.

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1773.0, 2017.0
30.0, 30.0

p158

p158

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

MO000068682

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c420 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18049472, 12881412 In endothelial cells, the ISG product guanylate binding protein 1, interferon-inducible, 67 kDa (GBP1), functioned as an inflammatory response factor inhibiting endothelial cell proliferation and angiogenesis in part through MMPs.

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575.0, 1647.0
25.0, 25.0

p159

p159

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c384 : 1
stoichiometry:c424 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes.

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648.0, 484.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000041446 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c47 : 1
stoichiometry:c46 : 1

m19314*m33*0.1

nodelay

--

true

0

false

PMID: 18049472 TLR3 recognizes dsRNA in the lumen of the endosome, which causes phosphorylation of specific tyrosine residues in TLR3 by an unidentified protein tyrosine kinase (PTK).

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860.0, 916.0
23.0, 23.0

p160

p160

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e78

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c426 : 1
stoichiometry:c425 : 1

m207*m82*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

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1372.0, 1264.0
23.0, 23.0

p161

p161

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000048 e38

MO000019343

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m131*m38*0.1

nodelay

--

true

0

false

PMID: 18049472 IRF3 requires further phosphorylation by the phosphatidylinositol 3-kinase (P13K)/AKT pathway for its full activation, which is initiated by binding PI3K to phosphorylated TLR3.

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712.0, 388.0
23.0, 23.0

p17

p17

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c48 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18049472 TLR3 dimerizes, binds to CD14 and activates the signalling complex assembled by TLR adaptor molecule 1 (TRIF).

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677.0, 533.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e35 MO000018132

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m35*m2828*0.1

nodelay

--

true

0

false

PMID: 18049472 TLR3 dimerizes, binds to CD14 and activates the signalling complex assembled by TLR adaptor molecule 1 (TRIF).

Go back
842.0, 592.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000041437 MO000016608 MO000019331

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c54 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c55 : 1

m1872*m19305*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 18049472 Two major pathways bifurcate from TRIF. One, composed of tumour necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and TANK-binding kinase (TBK1/IKKE), leads to phosphorylation of the transcription factor IFN regulatory factor 3 (IRF3).

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374.0, 1016.0
22.0, 22.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 e13

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m14*m13*0.1

nodelay

--

true

0

false

PMID: 18049472 It was also shown that microbial nucleic acids, lipids, polysaccharides or proteins trigger induction of IFNs through activation of TLRs.

Go back
840.0, 714.0
25.0, 25.0

p20

p20

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 18049472 Two major pathways bifurcate from TRIF. One, composed of tumour necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and TANK-binding kinase (TBK1/IKKE), leads to phosphorylation of the transcription factor IFN regulatory factor 3 (IRF3). PMID: 18049472, 16979567 IRFs are activated by the kinases TBK1 or IKK-epsilon activated IRFs then dimerize and translocate to the nucleus.

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842.0, 648.0
21.0, 21.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007694 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m977*m37*0.1

nodelay

--

true

0

false

PMID: 18049472 Two major pathways bifurcate from TRIF. One, composed of tumour necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and TANK-binding kinase (TBK1/IKKE), leads to phosphorylation of the transcription factor IFN regulatory factor 3 (IRF3).

Go back
703.0, 675.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000030 e35

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c265 : 1
stoichiometry:c65 : 1

m40*m35*0.1

nodelay

--

true

0

false

PMID: 18049472 IRF3 requires further phosphorylation by the phosphatidylinositol 3-kinase (P13K)/AKT pathway for its full activation, which is initiated by binding PI3K to phosphorylated TLR3.

Go back
915.0, 839.0
26.0, 26.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 MO000019343

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c267 : 1
stoichiometry:c428 : 1
stoichiometry:c427 : 1

m42*m3914*0.1

nodelay

--

true

0

false

PMID: 18049472 IRF3 requires further phosphorylation by the phosphatidylinositol 3-kinase (P13K)/AKT pathway for its full activation, which is initiated by binding PI3K to phosphorylated TLR3.

Go back
541.0, 819.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041437 MO000000212 MO000016574

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m19305*m183*m1573*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors.

Go back
692.0, 882.0
25.0, 25.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m207*m43*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors.

Go back
751.0, 947.0
25.0, 25.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e43

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m16910*m44*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes. PMID: 18049472 The IKK protein kinase complex phosphorylates IkappaB and releases it from NFkappaB.

Go back
858.0, 1044.0
23.0, 23.0

p27

p27

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000000254

MO000019479 MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c78 : 1
stoichiometry:c80 : 1

m208*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes. PMID: 18049472 The IKK protein kinase complex phosphorylates IkappaB and releases it from NFkappaB.

Go back
552.0, 1018.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e42 MO000000023

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m43*m47*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors.

Go back
677.0, 1039.0
25.0, 25.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e42 MO000000022

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m43*m49*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors.

Go back
381.0, 1375.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019399 MO000022185

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 18049472 It was also shown that microbial nucleic acids, lipids, polysaccharides or proteins trigger induction of IFNs through activation of TLRs.

Go back
588.0, 1122.0
25.0, 25.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 e46

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m45*m48*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
703.0, 1193.0
29.0, 29.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 MO000000049

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m63*m64*0.1

nodelay

--

true

0

false

PMID: 18049472 The other branch acts through TRAF6 and transforming growth factor-beta-activated kinase 1 (TAK1; also known as MAP3K7) leading to the activation of nuclear factor-kappaB (NFkappaB), JUN and activating transcription factor 2 (ATF2) transcription factors. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
910.0, 1248.0
23.0, 23.0

p32

p32

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016632

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
749.0, 1299.0
25.0, 25.0

p33

p33

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
645.0, 1211.0
23.0, 23.0

p34

p34

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e45

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
915.0, 1397.0
21.0, 21.0

p35

p35

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c104 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
813.0, 1407.0
25.0, 25.0

p36

p36

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e49

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c103 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
706.0, 1440.0
23.0, 23.0

p37

p37

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e63

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c102 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
903.0, 795.0
25.0, 25.0

p38

p38

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e40

e68 e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription.

Go back
959.0, 1253.0
21.0, 21.0

p39

p39

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e81

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c109 : 1

m85*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
372.0, 1054.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m155666*m17*0.1

nodelay

--

true

0

false

PMID: 18049472 It was also shown that microbial nucleic acids, lipids, polysaccharides or proteins trigger induction of IFNs through activation of TLRs.

Go back
959.0, 1381.0
21.0, 21.0

p40

p40

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 18049472 The activated transcription factors translocate from the cytoplasm to the nucleus, bind to the cognate sites in the promoters of the target genes and singly or in combinations induce their transcription. PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
961.0, 611.0
25.0, 25.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 MO000016963

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c116 : 1

m27*m1872*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
1032.0, 622.0
25.0, 25.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 MO000016963

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c115 : 1
stoichiometry:c117 : 1

m28*m1872*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
970.0, 780.0
23.0, 23.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016608 e71 e79

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c165 : 1
stoichiometry:c119 : 1

m1599*m75*m83*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes. PMID: 18049472, 16762830 Both TRIF and IPS1 recruit inhibitor of nuclear factor-kappaB (NFkappaB) kinase (IKK) and TANK-binding kinase (TBK1), the common activator kinases. PMID: 18049472, 16979567 IRFs are activated by the kinases TBK1 or IKK-epsilon activated IRFs then dimerize and translocate to the nucleus.

Go back
964.0, 826.0
27.0, 27.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e72 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m76*m977*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes. PMID: 18049472, 16979567 IRFs are activated by the kinases TBK1 or IKK-epsilon activated IRFs then dimerize and translocate to the nucleus.

Go back
1080.0, 638.0
25.0, 25.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m27*m77*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
1129.0, 579.0
25.0, 25.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m28*m77*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
621.0, 1027.0
23.0, 23.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e74

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m47*m78*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
754.0, 1068.0
23.0, 23.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e74

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m49*m78*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
773.0, 887.0
25.0, 25.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e74

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c138 : 1
stoichiometry:c137 : 1

m207*m78*0.1

nodelay

--

true

0

false

PMID: 18049472 IPS1 functions like TRIF and activates the same transcription factors leading to the induction of similar genes.

Go back
589.0, 263.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18049472, 15208624 dsRNA is recognized by TLR3, which is present mostly in endosomal membranes4, and also by two cytoplasmic RNA helicases, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation associated protein 5 (MDA5).

Go back
1073.0, 487.0
23.0, 23.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016899 e27

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
stoichiometry:c143 : 1

m1814*m27*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

Go back
1073.0, 531.0
23.0, 23.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016899 e28

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c142 : 1
stoichiometry:c144 : 1

m1814*m28*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

Go back
1093.0, 895.0
25.0, 25.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016906 e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c153 : 1
stoichiometry:c146 : 1

m1821*m80*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

Go back
1093.0, 931.0
25.0, 25.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016906 e75

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c155 : 1
stoichiometry:c148 : 1

m1821*m79*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

Go back
1098.0, 976.0
23.0, 23.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016900 e76

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c154 : 1
stoichiometry:c150 : 1

m1815*m80*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

Go back
1099.0, 1019.0
25.0, 25.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016900 e75

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c156 : 1
stoichiometry:c152 : 1

m1815*m79*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

Go back
845.0, 879.0
25.0, 25.0

p56

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e77

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m207*m81*0.1

nodelay

--

true

0

false

PMID: 18049472 In addition, they cause apoptosis by activating caspases 8 and 10 through the interaction of FADD with IPS1.

Go back
1006.0, 664.0
23.0, 23.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e27

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c166 : 1
stoichiometry:c162 : 1

m3902*m27*0.1

nodelay

--

true

0

false

PMID: 18049472, 16762830 Both TRIF and IPS1 recruit inhibitor of nuclear factor-kappaB (NFkappaB) kinase (IKK) and TANK-binding kinase (TBK1), the common activator kinases.

Go back
956.0, 718.0
19.0, 19.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e28

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c167 : 1
stoichiometry:c164 : 1

m3902*m28*0.1

nodelay

--

true

0

false

PMID: 18049472, 16762830 Both TRIF and IPS1 recruit inhibitor of nuclear factor-kappaB (NFkappaB) kinase (IKK) and TANK-binding kinase (TBK1), the common activator kinases.

Go back
380.0, 1510.0
27.0, 27.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e18 MO000041125

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m18*m18998*0.1

nodelay

--

true

0

false

PMID: 18049472 Bacterial lipopolysaccharides induce IFNs through TLR4 and also recruit TRIF.

Go back
893.0, 259.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000066987

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c20 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 18049472, 15208624 dsRNA is recognized by TLR3, which is present mostly in endosomal membranes4, and also by two cytoplasmic RNA helicases, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation associated protein 5 (MDA5).

Go back
698.0, 1512.0
23.0, 23.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e80

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c171 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 18049472 Bacterial lipopolysaccharides induce IFNs through TLR4 and also recruit TRIF.

Go back
916.0, 1100.0
24.0, 24.0

p61

p61

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c173 : 1

m19324*0.1

nodelay

--

true

0

false

Go back
1194.0, 362.0
28.0, 28.0

p62

p62

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

e26 e88

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m26*m92*0.1

nodelay

--

true

0

false

PMID: 18049472, 15710892 For example, a hepatitis C virus (HCV)-encoded protease can cleave IPS1 off the mitochondrial membrane and block RIG-I/MDA5-mediated signalling.

Go back
803.0, 371.0
26.0, 26.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e89 MO000066987

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m93*m41844*0.1

nodelay

--

true

0

false

PMID: 18049472, 17038589 NS1 protein of influenza viruses prevents establishment of an antiviral state through the interaction with RIG-I.

Go back
379.0, 463.0
25.0, 25.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e91 MO000042126

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m95*m19940*0.1

nodelay

--

true

0

false

PMID: 18049472, 11812998 the quinolinamine imiquimod and its analogues activate TLR7.

Go back
698.0, 1544.0
23.0, 23.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e93

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c187 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 18049472, 17562815 DMXAA induces IFN synthesis through a TLR-independent pathway.

Go back
710.0, 1572.0
23.0, 23.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c189 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18049472, 14991609 stimulation of TLR3 or TLR4 induces mostly IFN-beta and IFN-alpha1, which emphasizes the differences in the promoter sequences for the IFN-alphas, IFN-omega, and IFN-beta genes that govern the response to different inducers.

Go back
723.0, 1605.0
21.0, 21.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c190 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18049472, 14991609 stimulation of TLR3 or TLR4 induces mostly IFN-beta and IFN-alpha1, which emphasizes the differences in the promoter sequences for the IFN-alphas, IFN-omega, and IFN-beta genes that govern the response to different inducers.

Go back
790.0, 1671.0
21.0, 21.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c192 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18049472, 14991609 stimulation of TLR3 or TLR4 induces mostly IFN-beta and IFN-alpha1, which emphasizes the differences in the promoter sequences for the IFN-alphas, IFN-omega, and IFN-beta genes that govern the response to different inducers.

Go back
734.0, 1636.0
23.0, 23.0

p69

p69

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e18

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c191 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18049472, 14991609 stimulation of TLR3 or TLR4 induces mostly IFN-beta and IFN-alpha1, which emphasizes the differences in the promoter sequences for the IFN-alphas, IFN-omega, and IFN-beta genes that govern the response to different inducers.

Go back
977.0, 225.0
22.0, 22.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000103999

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c21 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 18049472, 15208624 dsRNA is recognized by TLR3, which is present mostly in endosomal membranes4, and also by two cytoplasmic RNA helicases, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation associated protein 5 (MDA5).

Go back
1737.0, 295.0
25.0, 25.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 e95

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c204 : 1
stoichiometry:c211 : 1

m104*m99*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1.

Go back
1737.0, 339.0
25.0, 25.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 MO000016660

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c205 : 1
stoichiometry:c212 : 1

m104*m1636*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1.

Go back
1738.0, 388.0
23.0, 23.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 MO000016667

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c206 : 1
stoichiometry:c213 : 1

m104*m1641*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1.

Go back
1743.0, 493.0
21.0, 21.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 e96

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c207 : 1
stoichiometry:c214 : 1

m104*m100*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1.

Go back
1742.0, 544.0
23.0, 23.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 e97

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c208 : 1
stoichiometry:c215 : 1

m104*m101*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1.

Go back
1742.0, 592.0
23.0, 23.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 e98

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c209 : 1
stoichiometry:c216 : 1

m104*m102*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1.

Go back
1742.0, 636.0
23.0, 23.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e100 e99

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c210 : 1
stoichiometry:c217 : 1

m104*m103*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1.

Go back
1485.0, 211.0
25.0, 25.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016658 e100

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1

m1634*m104*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2. PMID: 18049472, 17969444 They act through a cell-surface receptor composed of two ubiquitously expressed transmembrane proteins, IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2 (the genes for which are clustered on chromosome 21), and are associated with two cytoplasmic tyrosine kinases, TYK2 and JAK1. PMID: 18049472, 17969444 Formation of the IFN?receptor complex involves one side of the IFN protein interacting with IFNAR2 in a region forming the hinge between the two fibronectin type III (FnIII) domains (Fig. 3); binding affinity is in the nanomolar range39. IFNAR1 binds IFNs with an affinity 1,000-fold weaker than that of IFNAR2, with a binding site located opposite to the IFNAR2 binding site. Binding studies are consistent with the ternary complex between IFNAR1, IFN and IFNAR2 having a 1:1:1 stoichiometry, and a similar if not identical architecture for all type I IFNs. Ternary complex assembly is a two-step process; the ligand binds first to one IFNAR and then recruits the second with no identified interaction between the two IFNARs.

Go back
1742.0, 925.0
25.0, 25.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e109 MO000016665

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m113*m1639*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2; type II IFN-gamma with IFN-gamma receptor 1 (IFNGR1) and IFNGR2; and type III IFN-lambdas with IFN-lambda receptor 1 (IFNLR1; also known as IL28RA) and interleukin 10 receptor 2 (IL10R2; also known as IL10RB). PMID; 18049472 Type II IFN-gamma is an antiparallel homodimer exhibiting a two-fold axis of symmetry. It binds two IFNGR1 receptor chains, assembling a complex that is stabilized by two IFNGR2 chains. PMID: 18049472 Type II IFN-gamma is an antiparallel homodimer exhibiting a two-fold axis of symmetry. It binds two IFNGR1 receptor chains, assembling a complex that is stabilized by two IFNGR2 chains. These receptors are associated with two kinases from the JAK family: JAK1 and TYK2 for type I and III IFNs; JAK1 and JAK2 for type II IFN. PMID: 18049472 IFN-gamma receptor 1 (IFNGR1) maps to chromosome 6 and has a JAK1 binding domain and a STAT1 docking site. IFNGR2 contains a JAK2 binding domain and maps to chromosome 21q22.1 in a cluster that also contains IFNAR1, IFNAR2 and interleukin 10 receptor 2 (IL10R2; also known as IL10RB).

Go back
1746.0, 756.0
23.0, 23.0

p79

p79

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e111 e114

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m115*m118*0.1

nodelay

--

true

0

false

PMID: 18049472 Type I interferons (IFNs) (alpha, beta omega, kappa, epsilon, delta (pigs), tau (ruminants)) interact with IFN (alpha, beta and omega) receptor 1 (IFNAR1) and IFNAR2; type II IFN-gamma with IFN-gamma receptor 1 (IFNGR1) and IFNGR2; and type III IFN-lambdas with IFN-lambda receptor 1 (IFNLR1; also known as IL28RA) and interleukin 10 receptor 2 (IL10R2; also known as IL10RB). PMID: 18049472 These receptors are associated with two kinases from the JAK family: JAK1 and TYK2 for type I and III IFNs.

Go back
382.0, 1468.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e23 MO000019395

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m23*m3962*0.1

nodelay

--

true

0

false

PMID: 18049472 It was also shown that microbial nucleic acids, lipids, polysaccharides or proteins trigger induction of IFNs through activation of TLRs.

Go back
1424.0, 186.0
27.0, 27.0

p80

p80

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e108

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c228 : 1

m112*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1750.0, 812.0
23.0, 23.0

p81

p81

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e112

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1

m116*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1364.0, 186.0
27.0, 27.0

p82

p82

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e115

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m119*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1370.0, 424.0
23.0, 23.0

p83

p83

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e117 e113

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m121*m117*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1749.0, 867.0
25.0, 25.0

p84

p84

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e118

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1

m122*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1370.0, 488.0
23.0, 23.0

p85

p85

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e119 e113

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c243 : 1
stoichiometry:c244 : 1

m123*m117*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1759.0, 983.0
25.0, 25.0

p86

p86

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e110

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c236 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1759.0, 1042.0
23.0, 23.0

p87

p87

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e120

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c238 : 1

m124*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs. PMID: 18049472 Minimum requirements for a response to type I IFNs are the heterodimeric IFN receptor; the tyrosine kinases TYK2 and JAK1, which reciprocally transphosphorylate the receptor chains when activated.

Go back
1588.0, 1104.0
23.0, 23.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e121 MO000013119 MO000013122

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c247 : 1
stoichiometry:c248 : 1
stoichiometry:c246 : 1

m125*m1357*m1360*0.1

nodelay

--

true

0

false

PMID: 18049472, 15284232 STAT1 and STAT3 bind competitively to the same phosphotyrosine residue of IFNGR1, with the binding of STAT1 greatly favoured.

Go back
1774.0, 1172.0
23.0, 23.0

p89

p89

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e123

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c250 : 1

m127*0.1

nodelay

--

true

0

false

PMID: 18049472 Upon activation of receptors, the JAKs undergo autophosphorylation and transphosphorylation to increase their activity, and then phosphorylate the IFN receptors and finally STATs.

Go back
707.0, 1481.0
22.0, 22.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18049472 It was also shown that microbial nucleic acids, lipids, polysaccharides or proteins trigger induction of IFNs through activation of TLRs.

Go back
1771.0, 1331.0
25.0, 25.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016658 e125

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m1634*m129*0.1

nodelay

--

true

0

false

PMID: 18049472, 12169689 In at least some cell types, the p85 subunit of phosphatidylinositol 3-kinase (PI3K) is associated with IFNAR1. The activation of p85 by IFN leads to AKT phosphorylation and expression of the chemokine (C-X-C motif) ligand 11 (CXCL11) gene, encoding an important chemokine.

Go back
1571.0, 1283.0
25.0, 25.0

p91

p91

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000048 e126

MO000019343

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c256 : 1
stoichiometry:c255 : 1

m131*m130*0.1

nodelay

--

true

0

false

PMID: 18049472, 12169689 In at least some cell types, the p85 subunit of phosphatidylinositol 3-kinase (PI3K) is associated with IFNAR1. The activation of p85 by IFN leads to AKT phosphorylation and expression of the chemokine (C-X-C motif) ligand 11 (CXCL11) gene, encoding an important chemokine.

Go back
1145.0, 1403.0
25.0, 25.0

p92

p92

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000019343

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c257 : 1

m3914*0.1

nodelay

--

true

0

false

PMID: 18049472, 12169689 In at least some cell types, the p85 subunit of phosphatidylinositol 3-kinase (PI3K) is associated with IFNAR1. The activation of p85 by IFN leads to AKT phosphorylation and expression of the chemokine (C-X-C motif) ligand 11 (CXCL11) gene, encoding an important chemokine. PMID: 18049472, 9625760, 2115167, 8798467 As examples, three closely related chemokines involved in accumulation of activated T cells and macrophages are the ISGs CXCL9 (also known as MIG, monokine induced by IFN-gamma); CXCL10 (also known as IP-10, IFN-gamma 10 kD inducible protein); and CXCL11 (also known as I-TAC, interferon-inducible T-cell alpha-chemoattractant)136, 137, 138, 139. True to their names, these chemokines are not expressed in the absence of IFN signalling.

Go back
1248.0, 1404.0
23.0, 23.0

p93

p93

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G012252

MO000017271

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c260 : 1

m95041*0.1

nodelay

--

true

0

false

PMID: 18049472, 12169689 In at least some cell types, the p85 subunit of phosphatidylinositol 3-kinase (PI3K) is associated with IFNAR1. The activation of p85 by IFN leads to AKT phosphorylation and expression of the chemokine (C-X-C motif) ligand 11 (CXCL11) gene, encoding an important chemokine. PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes.

Go back
711.0, 1139.0
25.0, 25.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000022 e108

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c263 : 1
stoichiometry:c262 : 1

m49*m112*0.1

nodelay

--

true

0

false

PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes.

Go back
1051.0, 1343.0
25.0, 25.0

p95

p95

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016660

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c422 : 1
stoichiometry:c264 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes. PMID: 18049472, 9625760, 2115167, 8798467 As examples, three closely related chemokines involved in accumulation of activated T cells and macrophages are the ISGs CXCL9 (also known as MIG, monokine induced by IFN-gamma); CXCL10 (also known as IP-10, IFN-gamma 10 kD inducible protein); and CXCL11 (also known as I-TAC, interferon-inducible T-cell alpha-chemoattractant)136, 137, 138, 139. True to their names, these chemokines are not expressed in the absence of IFN signalling.

Go back
865.0, 1567.0
25.0, 25.0

p96

p96

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c269 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes.

Go back
1007.0, 1367.0
25.0, 25.0

p97

p97

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016660

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c421 : 1
stoichiometry:c268 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes.

Go back
1261.0, 1487.0
25.0, 25.0

p98

p98

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e165

MO000017871

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c397 : 1
stoichiometry:c270 : 1

m173*0.1

nodelay

--

true

0

false

PMID: 18049472, 14607926 Type I IFNs also activate p38, and inactivation of p38 blocks induction by IFN-beta of CXCL11 and TNFSF10 (encoding tumour necrosis factor-related apoptosis-inducing ligand, APO2L/TRAIL)68 and of CXCL10 (encoding the chemokine IP-10; also known as IFN-gamma-induced peptide, 10 kDa) in primary leukocytes.

Go back
1340.0, 1048.0
23.0, 23.0

p99

p99

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c273 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 18049472, 17969446 Serine 727 of STAT1 is phosphorylated in response to IFN-gamma by the kinase cascade PI3K¡½AKT¡½PKC¡½MKK4¡½p38 (MKK4, mitogen-activated protein kinase kinase 4; also known as MAP2K4), with some variation in the activation of different PKC or MKK proteins in different cells.

Go back
331.0, 943.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.7839864320407, 1351.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.0, 1390.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.0, 1369.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.0, 1458.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.0, 1432.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.0, 1418.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.0, 755.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.8623479330104, 820.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 808.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.0, 1069.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.0, 1274.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
345.0, 1387.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.0, 1353.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
970.0, 1402.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.0, 535.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1042.0, 592.0

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 598.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.0, 593.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 635.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1050.0, 647.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 694.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
993.0, 794.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
406.0, 1388.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.357368059134, 729.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
997.6883832866965, 810.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
922.0, 768.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.8394669899402, 853.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.0, 531.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1054.0, 575.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1143.6379617782632, 611.974522228289

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.0919072608465, 604.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.9940893970504, 649.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.0, 663.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.0, 293.9924492668405

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.0, 1089.4246907579125

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 1091.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.610709440471, 858.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
615.0, 1010.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.3813823519705, 1050.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
651.415162343721, 854.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.0, 867.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.4435011210878, 909.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.8947623081548, 850.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1103.8446454055274, 502.56892908110547

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0813141194785, 187.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1103.5615216437443, 520.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 502.1562695226027

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 555.2719439311038

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 470.9522635832987

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1096.0, 545.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1056.0, 908.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1062.9574873218896, 915.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1056.0, 916.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 944.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1063.0, 988.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.0, 286.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1073.2273043158027, 997.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1063.0, 999.0

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1074.984420627863, 1033.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.9999228518413, 587.0

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1128.9997724292186, 587.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1125.999965104648, 463.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1131.9999714309565, 468.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.0, 858.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.3225202593821, 898.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.6940264912081, 897.1913366588884

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.0, 190.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.0, 862.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 642.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 687.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.0, 650.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.0, 728.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.869488893521, 742.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
976.0, 535.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
974.4394686431388, 592.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
295.0224487225184, 1105.7522947106868

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.625150265808, 307.70163629589115

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
873.0, 291.5806056571633

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.0, 1524.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.0, 1526.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
482.0, 1524.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.0, 1124.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.0, 1226.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.0, 376.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1125.0, 235.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1222.0, 375.6029423706159

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0240584455314, 235.0

c178

c178

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1043.13304622214, 235.0

c179

c179

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
796.0, 184.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 402.9619305082008

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.0, 384.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 394.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.0, 469.0

c183

c183

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
343.0, 476.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.87346659178957, 479.4172239865221

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 476.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.0, 1545.676232709847

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
381.0, 1556.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
733.0, 1584.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 254.97569713079395

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 1594.2635204975204

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.0, 1638.2987830845307

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.0, 1654.9930645847387

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
265.95223429664253, 1095.7819592827764

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
249.71281990376661, 1087.7899539631994

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
229.8522266378119, 251.50136527640575

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
201.6568062338688, 215.5073749701155

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1688.0, 327.1554175279993

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1692.0, 370.4904638506382

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1692.0, 413.66326300361385

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 943.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
907.0, 284.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1692.0, 462.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1692.0, 472.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1688.0, 473.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1686.0, 473.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1770.0, 308.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1770.0, 352.0

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1769.0, 400.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1772.0, 504.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1773.0, 556.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1773.0, 604.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.0, 247.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1773.0, 648.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1703.0, 308.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1700.0, 352.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1699.0, 400.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1696.0, 504.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1697.0, 556.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1694.0, 604.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1695.0, 648.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1498.0, 182.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1511.9664389532297, 242.2717209858094

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
309.0, 1480.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1498.0, 236.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1690.0, 936.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1774.999666416479, 936.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1698.492274731612, 948.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1758.1817712428262, 712.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1691.0, 724.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1700.0, 768.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1447.2291216526103, 220.31934241258347

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1438.0, 213.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1391.4950642846643, 219.61773353020018

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.2100193962015, 1450.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1378.0, 213.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1692.0, 778.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1702.0, 824.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1694.0, 835.0

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1704.0, 880.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1692.0, 996.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1701.7839864320406, 1004.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1695.0, 1054.2498780190217

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1700.76638371118, 1062.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1379.0, 306.0

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
405.0, 1480.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1395.9377781847743, 517.2943106531189

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1326.0, 436.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1318.5326199862716, 444.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1326.0, 450.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1319.9952479948288, 497.27569820671823

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1619.0, 1116.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1611.0, 1126.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1551.0, 1116.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1600.0, 1135.0

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1702.0, 1184.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.0, 1500.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1703.8284458441758, 1191.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1512.0, 168.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1690.0, 1344.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1695.552284336963, 1349.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1459.0, 1260.0

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1472.0, 1296.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1601.6568542494924, 1313.6568542494924

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1091.4855782911504, 1421.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1177.3962549536063, 1303.0

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1033.0, 1425.5643777839016

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.0, 1481.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1271.0, 1416.0

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.0, 1133.0

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 1160.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.9911785045441, 357.0

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1064.0, 1368.0

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.1545605178945, 468.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.0, 1211.0

c266

c266

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
889.0, 849.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1020.0, 1392.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.9917483216824, 1581.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
844.0, 468.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1286.0, 1500.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1004.3829385913779, 1591.8226647134854

c271

c271

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1058.0, 1063.1235057517881

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1339.0212779635738, 1071.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1058.0, 1104.0

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1459.0, 1241.9223788068985

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1471.3988560332946, 1245.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1352.0, 1191.0

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1560.0, 1390.908372729286

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1464.0, 1305.0

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
686.0, 412.1927794053147

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1559.0, 1479.0

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1567.6262673050237, 1397.0

c281

c281

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1557.0, 1445.0

c282

c282

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.0407268278663, 1170.798442540748

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 1130.0

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
814.4246907579123, 1173.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1469.990799894733, 1489.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1475.0, 1116.0

c287

c287

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1456.0, 1127.0

c288

c288

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.0, 1119.0746989553393

c289

c289

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.907883951425, 546.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1211.9279394432826, 1262.0713431680113

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.1554175279994, 1196.0

c291

c291

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1204.0, 1268.0

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1356.0, 1928.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1367.0, 1966.0

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1312.0, 1116.0

c295

c295

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1359.0, 1975.0

c296

c296

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1508.0, 472.8940545478517

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.0, 1139.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 1223.0

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 1027.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.0, 440.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1368.0, 2002.0

c300

c300

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1408.8374782761443, 2013.0

c301

c301

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
568.0, 1268.0

c302

c302

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.7552116849392, 1279.0

c303

c303

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
628.611177085964, 1208.0

c304

c304

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1521.0, 732.0745328934241

c305

c305

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1512.0, 787.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1282.1778465754876, 465.0

c307

c307

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.7429825404315, 720.0

c308

c308

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.2802676408019, 805.3162784983011

c309

c309

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
985.5060759548519, 381.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1579.0, 452.0

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1595.0, 716.0

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1595.0, 936.0

c312

c312

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1458.914007794266, 1189.0

c313

c313

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1448.0, 1405.0

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1468.0, 1448.0

c315

c315

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1271.0, 1186.3589809133919

c316

c316

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1559.9869706753918, 1177.0

c317

c317

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1361.324391861868, 1186.0

c318

c318

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.0, 1882.0

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0, 481.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 1920.0

c320

c320

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
172.4547405620664, 179.53922997500683

c321

c321

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.1738719632738, 1938.0

c322

c322

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
566.0, 1969.0

c323

c323

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
577.0, 1996.0

c324

c324

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 2009.0

c325

c325

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 2040.0

c326

c326

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 2040.0

c327

c327

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.2423130131261, 1995.996329433163

c328

c328

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 1944.9940893970504

c329

c329

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 432.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 1920.0

c330

c330

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.0, 1929.0

c331

c331

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.0, 1937.0

c332

c332

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.0, 1988.0

c333

c333

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.0, 1998.0

c334

c334

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.0, 2033.0

c335

c335

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
148.98044033165218, 150.9999521771358

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 1973.0

c337

c337

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 2022.0

c338

c338

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
134.88167941858342, 133.99824964703475

c339

c339

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1049.1281010703615, 389.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
827.8495012885248, 1597.1333197430754

c340

c340

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.2589500159179, 1605.0285524572716

c341

c341

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
821.0, 1586.0

c342

c342

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
821.0, 1587.0

c343

c343

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1312.0, 357.99908482156746

c344

c344

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1288.0, 350.09080973825553

c345

c345

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
109.17273978036701, 109.75186580979414

c346

c346

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
84.76420303676252, 101.55989657221335

c347

c347

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
64.34270111812549, 87.52582630592701

c348

c348

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
44.24434300604855, 75.56070557307021

c349

c349

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1038.0, 495.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
706.0, 1824.7354436625492

c350

c350

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 1830.0

c351

c351

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.5894868772428, 180.0

c352

c352

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 1847.0

c353

c353

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 1864.0

c354

c354

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.5777087639997, 1881.1554175279994

c355

c355

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
887.0326527670904, 1878.0

c356

c356

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 1916.0

c357

c357

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
859.0, 1878.0

c358

c358

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
953.0, 1929.0

c359

c359

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 559.2399915200255

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 1992.0

c360

c360

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.0, 1972.0

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.506083455352, 1989.8037095880738

c362

c362

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 1920.0

c363

c363

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.0, 1963.0

c364

c364

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.8479626207359, 1897.4759018794318

c365

c365

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.0, 2013.0

c366

c366

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.0, 2008.0

c367

c367

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 2042.962650940154

c368

c368

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
988.0, 1872.0

c369

c369

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
341.0, 605.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
968.0, 1775.0

c370

c370

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1365.0, 1500.0

c371

c371

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1155.0, 214.67762028542168

c372

c372

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1531.924327217253, 938.0

c373

c373

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1470.0, 1004.0

c374

c374

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.0, 1347.0

c375

c375

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1116.708706406952, 519.0

c376

c376

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1017.7560768727265, 1771.0634188978263

c377

c377

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1053.8006795489705, 1766.039519512441

c378

c378

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1073.917081907723, 1737.975418935676

c379

c379

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
415.80315742433066, 511.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.0028719586807, 1677.288244344552

c380

c380

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1007.8466608896548, 1681.0144992693706

c381

c381

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.9626509401539, 1681.9418702562696

c382

c382

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1039.3488508903354, 1480.0

c383

c383

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
607.5490164590915, 1589.0

c384

c384

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.1554175279994, 1512.5777087639997

c385

c385

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.205809802785, 1682.3295827649579

c386

c386

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1218.9999037162906, 950.0

c387

c387

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1135.2273043158027, 1563.0220196095183

c388

c388

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1287.0, 1558.3151160102107

c389

c389

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 547.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1408.0, 2208.0

c390

c390

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1388.0, 2143.0

c391

c391

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1400.386855697762, 2135.0

c392

c392

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1217.0, 1572.0

c393

c393

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1294.9998668807914, 336.3315732538622

c394

c394

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1186.999999238453, 320.26218514588254

c395

c395

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1537.0, 1556.0

c396

c396

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1209.0, 1478.0

c397

c397

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1102.7839864320406, 1580.2399915200253

c398

c398

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1190.9999989749272, 308.0

c399

c399

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
403.3587460644701, 993.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.70814327703954, 596.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1546.0, 1804.0

c400

c400

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1544.0, 1820.6568542494924

c401

c401

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1588.0, 1823.0

c402

c402

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1553.6568542494924, 1769.6568542494924

c403

c403

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1548.0, 1748.0

c404

c404

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1354.0, 1515.0

c405

c405

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1445.0, 1748.0

c406

c406

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1387.0, 1748.0

c407

c407

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1378.3064601145268, 1761.0

c408

c408

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1551.0, 1944.0

c409

c409

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
417.0, 639.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1554.0, 1904.0

c410

c410

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1552.9965420357148, 1981.0

c411

c411

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1610.9999943436737, 950.0

c412

c412

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1612.999995824821, 950.0

c413

c413

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1611.9999990524345, 950.0

c414

c414

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1101.3229641980356, 1622.9721061734058

c415

c415

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1238.0, 1708.0

c416

c416

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1097.0, 1612.0

c417

c417

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1153.340626390577, 1691.7686497423997

c418

c418

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1234.8061567506131, 1711.9179218079794

c419

c419

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
424.0, 699.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1542.0, 2032.0

c420

c420

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1039.999158164853, 366.0

c421

c421

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1083.9642257159578, 363.0

c422

c422

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1121.9999999035497, 366.0

c423

c423

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
19.66604123413333, 55.5844765191722

c424

c424

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
727.8552500606081, 930.0

c425

c425

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.8397445745082, 939.1494450418683

c426

c426

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.0, 865.0

c427

c427

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
947.0854115644094, 868.1930497871437

c428

c428

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 699.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 702.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.0, 471.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 459.8629774954746

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.6921915811266, 467.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
722.4697761756117, 411.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.5647693945351, 468.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 1027.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.3437486849008, 505.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 540.4045450586659

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.8094964814716, 591.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
802.0, 536.5150582239837

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
810.0, 589.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.9294846883888, 611.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.4688030358325, 621.6354954168422

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.2494651199621, 612.383083722649

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.0, 707.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
799.7611400011626, 730.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.1554175279993, 907.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
863.1927794053147, 675.8132665336364

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.0, 642.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.7381712052921, 666.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1402.6115561484353, 1261.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.9339663261525, 706.2972991267998

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 700.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1395.0, 1279.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.0, 795.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.564676836918, 600.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.5851508263321, 849.570798848544

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
327.0, 1067.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.0, 850.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.0, 831.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.145770236779, 865.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
704.2161372907833, 907.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.0, 842.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
783.9569472711262, 954.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 968.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 960.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
881.0, 809.3876802613671

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 1020.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.99920662468196, 1067.1126648820377

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
867.796029752168, 1067.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
569.7152583587409, 854.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
617.0, 854.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
583.0455126623185, 1008.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
575.0, 1043.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 1071.6331719007019

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.0, 1064.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 1134.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 1147.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 1089.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.0, 1072.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.990651168656, 1204.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.0, 1179.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.0, 1222.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 1121.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0, 1271.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 1278.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 1324.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.0, 1223.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
663.0, 1234.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.9619305082008, 1425.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back