1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18054516.csml convertedTime:2009.07.01.11:11

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title IFN regulation and functions in myeloid dendritic cells.
Authors Coccia EM.
Affiliation Department of Infectious, Parasitic and Immune-mediated Diseases, IstitutoSuperiore di Sanita, 00161 Rome, Italy. eliana.coccia@iss.it
Abstract A central issue in dendritic cells (DC) biology is to understand how type I IFNsmodulate the immuno-regulatory properties of DC. In this review I will addressthis issue in light of the recent experimental evidence on the expression andfunction of these cytokines in myeloid DC. This knowledge may have importanttherapeutic implications in infectious and neoplastic diseases and open newperspectives in the use of IFNs as vaccine adjuvants and in the development ofDC-based vaccines.
PMID 18054516
Model Abstract

Entity

G011682:STAT2 G011698:STAT4 MO000000058:NF-kappaB MO000000248:IKK MO000000289:TNF-alpha MO000007694:IRF-3 MO000007702:IRF-7 MO000013119:STAT1 MO000013120:STAT2 MO000016573:MyD88 MO000016882:LPS MO000017181:STAT4 MO000017197:Pin1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019479:protein remnants MO000019704:STAT1{p} MO000022185:flagellin MO000022224:dsRNA MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000055971:ATF-2:c-Jun MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e100:CXCL11 e101:IL-12 e102:IL-12 e103:CD40 e104:Stat1 e105:STAT4 e106:target genes e107:IL-1beta e108:CD40L e11:peptidoglycan:TLR2 e12:peptidoglycan e13:lipopolypeptides e14:lipopolypeptides:TLR2 e15: e16: e17: e18:flagellin:TLR5 e19:ssRNA:TLR7 e2: e20:ssRNA e21:ssRNA:TLR8 e22:CpG DNA e23:CpG DNA:TLR9 e24:LPS:TLR4:MD2:TRAM e25:LPS:TLR4:MD2:TRAM:TRIF e26:imiquimod e27:imiquimod:TLR7 e28:R-848 e29:R-848:TLR8 e3: e30:R-848:TLR7 e31:LPS:TLR4:MD2:MYD88 e32:flagellin:TLR5:MYD88 e33:peptidoglycan:TLR2:MYD88 e34:ssRNA:TLR7:MYD88 e35:ssRNA:TLR8:MYD88 e36:CpG DNA:TLR9:MYD88 e37:IKK-i:TBK1 e38:IKK-i:TBK1{active} e39:IRF-3{p} e4: e40:IRF-7{p} e41:enhanceosome complex e42:IFN-beta e43:NF-kappaB{active} e44:IFN-alpha e45:ISGF3 e46:ISGF3{active} e47:IFN-beta e48:IRF7 e49:IRF-3{p}:pin1 e5:TLR4:MD2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LPS:TLR4:MD2 e60: e61: e62: e63:IRF-3{p}{ub}:pin1 e64:SARM e65:SIKE e66:IKK-i:SIKE:TBK1 e67:JAK e68:JAK{active} e69:(stat1{p})2 e7: e70:(stat1{p})2 e71:(stat1{p})2:IRF1SBE DNA e72:IRF1SBE e73:IRF7 ISRE:ISGF3{act} e74:IRF7 ISRE e75:IRF1 e76:IFN-alpha1 e77:IFN-alpha1 e78:dsRNA:DDX58 e79:dsRNA:IFIH1 e8: e80:dsRNA:DDX58:MAVS e81:dsRNA:DDX58:MAVS:IKK e82:NF-kappaB e83:IRF e84:IRF{active} e85:DAI e86:DNA:DAI e87:HLA-DR e88:HLA-DR e89:CD54 e9: e90:CD54 e91:CD80 e92:CD80 e93:CD86 e94:CD86 e95:CXCL9 e96:CXCL9 e97:CXCL10 e98:CXCL11 e99:CXCL10

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98
Model Detail
649.0, 1125.0
30.0, 30.0

STAT2

--

G011682

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p87 p88

true true true true

csml-variable:Double

m94507

10

false

infinite

0

unit false false false
TRANSFACG011682

--

Go back
827.0, 1135.0
26.0, 26.0

STAT4

--

G011698

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p89

p90

true true true true

csml-variable:Double

m94523

10

false

infinite

0

unit false false false
TRANSFACG011698

--

Go back
697.0, 1089.0
30.0, 30.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29 p30 p31 p32 p33 p34

p27 p89

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
458.0, 294.0
28.0, 28.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
7.0, 767.0
34.0, 34.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p96

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1018.0, 798.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1133.0, 793.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1056.0, 1296.0
24.0, 24.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p85 p86

p45

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
457.0, 941.0
30.0, 30.0

STAT2

--

MO000013120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p87 p88

--

true true true true

csml-variable:Double

m1358

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013120

--

Go back
1018.0, 254.0
27.0, 27.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p16 p17 p18 p19 p20

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1415.0, 191.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
907.0, 1003.0
26.0, 26.0

STAT4

--

MO000017181

cso30:c:Protein

cso30:i:CC_CellComponent

--

p90

p91

true true true true

csml-variable:Double

m2053

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000017181

--

Go back
830.0, 1314.0
20.0, 20.0

Pin1

--

MO000017197

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p38

true true true true

csml-variable:Double

m2065

10

false

infinite

0

unit false false false
InterProIPR000297
TRANSPATHMO000017197

--

Go back
1148.0, 155.5
24.5, 24.5

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
956.0, 508.0
24.0, 24.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
957.0, 153.0
30.0, 30.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
807.0, 1563.0
26.0, 26.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1082.0, 1454.0
28.0, 28.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

p46

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
855.0, 59.0
26.0, 26.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
896.0, 228.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p54 p55

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1135.0, 523.0
26.0, 26.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p11

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1168.0, 252.0
24.0, 24.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
982.0, 590.0
28.0, 28.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

p21

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
983.0, 555.0
26.0, 26.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

p9 p42 p85 p87 p94

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1031.0, 931.0
26.0, 26.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p25

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
1135.0, 939.0
26.0, 26.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p26

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
803.0, 439.0
34.0, 34.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p13

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
745.0, 481.0
30.0, 30.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
858.0, 442.0
27.0, 27.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p12 p14

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
723.0, 1299.0
26.0, 26.0

ATF-2:c-Jun

--

MO000055971

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m31298

10

false

infinite

0

unit false false false
TRANSPATHMO000055971

--

Go back
686.0, 222.0
27.0, 27.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
533.0, 301.0
22.0, 22.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
956.0, 232.0
24.0, 24.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
73.64600216621963, 132.6250881165839
1205.5002660341918, 1750.3863862816456

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
87.26091329323367, 166.37893352416827
1168.4989138912963, 1643.749407980475

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
33.0, 1557.3
29.6, 22.200000000000006

CXCL11

--

e100

cso30:c:Protein

cso30:i:CC_Cytosol

--

p77 p78

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
360.0, 1317.0173010380624
39.34256055363322, 20.982698961937718

IL-12

--

e101

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p83

p84

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
13.0, 1371.331354397263
29.462668544978868, 18.16864560273697

IL-12

--

e102

cso30:c:Protein

cso30:i:CC_Cytosol

--

p84

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
275.0, 1820.6599999999999
41.120000000000005, 30.839999999999996

CD40

--

e103

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p83 p84

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
851.0, 1172.9100346020764
41.418685121107266, 22.089965397923876

Stat1

--

e104

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p85 p86

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
875.0, 891.0
26.0, 26.0

STAT4

--

e105

cso30:c:Protein

cso30:i:CC_CellComponent

--

p91

p92

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000017181

--

Go back
509.0, 1125.9307958477507
37.62975778546713, 20.06920415224914

target genes

--

e106

cso30:c:mRNA

cso30:i:CC_Extracellular

--

p92

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
23.0, 837.6879653853894
33.74924532099014, 20.81203461461059

IL-1beta

--

e107

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p97

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
20.0, 938.8655536028118
39.437609841827765, 25.63444639718805

CD40L

--

e108

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p98

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1089.5, 148.50866038149525
20.4038588028941, 39.49133961850472

peptidoglycan:TLR2

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p17 p93

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1191.0, 27.908326324642587
42.51471825063078, 24.09167367535745

peptidoglycan

--

e12

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1024.0, 2.956942003514939
39.297012302284706, 25.543057996485057

lipopolypeptides

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1033.5, 144.25871519403643
20.532997149747864, 39.7412848059636

lipopolypeptides:TLR2

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
760.0, 450.50586919007065
255.6267612311074, 426.7667115468489

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
760.0, 450.50586919007065
255.6267612311074, 426.7667115468489

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
760.0, 450.50586919007065
255.6267612311074, 426.7667115468489

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
897.5, 148.5612804209602
20.376671782503834, 39.438719579039685

flagellin:TLR5

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p16

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
901.5, 455.31155448366593
21.02236351677264, 40.688445516334134

ssRNA:TLR7

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p18

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
73.64600216621963, 132.6250881165839
1205.5002660341918, 1750.3863862816456

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
853.0, 321.90495505371626
37.92589344442008, 19.595044946283707

ssRNA

--

e20

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p5 p6

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
770.5, 449.2056566542425
19.527077395308044, 37.794343345757504

ssRNA:TLR8

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p19

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
646.0, 389.5
60.0, 13.0

CpG DNA

--

e22

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p8 p60

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
754.5, 529.2582766937074
19.49989037491778, 37.74172330629248

CpG DNA:TLR9

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p20

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1217.0, 289.2058823529412
22.67647058823529, 37.794117647058826

LPS:TLR4:MD2:TRAM

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1237.0, 346.2647058823529
21.441176470588236, 35.735294117647065

LPS:TLR4:MD2:TRAM:TRIF

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p22

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
969.0, 361.8536585365853
37.3170731707317, 21.146341463414632

imiquimod

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p12

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
933.5, 472.9427757070818
20.179565884674414, 39.05722429291823

imiquimod:TLR7

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
655.0, 518.2548359966357
34.84440706476031, 19.745164003364174

R-848

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p13 p14

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
758.5, 573.6658627493971
18.772637579478182, 36.33413725060295

R-848:TLR8

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
97.75600748690337, 156.73509343726786
1157.2802553928234, 1702.1663756402781

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
765.5, 616.6270554702917
20.342688007016, 39.3729445297084

R-848:TLR7

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
820.0, 147.67647058823525
24.794117647058826, 41.32352941176472

LPS:TLR4:MD2:MYD88

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p29

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
755.5, 150.70912093962193
25.291796659937603, 35.29087906037805

flagellin:TLR5:MYD88

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p33

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1202.5, 145.3747476601211
26.964764176913192, 37.625252339878884

peptidoglycan:TLR2:MYD88

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p34

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
760.5, 668.7832629840339
22.37199486144247, 31.21673701596625

ssRNA:TLR7:MYD88

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p30

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
756.5, 716.4088823637367
22.640300972655538, 31.59111763626353

ssRNA:TLR8:MYD88

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p31

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1005.5, 625.9634795375298
20.809506331436964, 29.03652046247019

CpG DNA:TLR9:MYD88

--

e36

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p20

p32

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1092.0, 646.8121546961324
23.56906077348067, 26.1878453038674

IKK-i:TBK1

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p21 p22 p41

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1086.0, 761.6187845303867
19.243093922651937, 21.381215469613267

IKK-i:TBK1{active}

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21 p22 p42

p23 p24

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
867.0, 1255.0
26.0, 26.0

IRF-3{p}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p27 p38 p52

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
142.35951733016864, 198.9276027484641
1068.0732357062939, 1617.7813570178828

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
835.0, 1211.0
26.0, 26.0

IRF-7{p}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p27

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
796.0, 1356.0294117647056
23.382352941176467, 38.97058823529412

enhanceosome complex

--

e41

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p27

p28

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
730.0, 1436.249134948097
44.53287197231833, 23.750865051903116

IFN-beta

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28

p51

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
649.0, 805.0
30.0, 30.0

NF-kappaB{active}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58 p93 p94 p95 p96 p97 p98

p29 p30 p31 p32 p33 p34

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1385.5, 1249.5250553431276
24.95954920507144, 40.474944656872616

IFN-alpha

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36 p43 p61 p63 p64 p65 p66 p67 p68 p69 p70 p71 p73 p75 p77 p79 p81 p91

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
791.0, 1639.5884003741817
17.51169317118802, 40.41159962581852

ISGF3

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35 p36

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
699.0, 1664.7464920486434
17.876520112254443, 41.25350795135642

ISGF3{active}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35 p36

p49

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1375.0, 1433.6879653853894
33.74924532099014, 20.812034614610585

IFN-beta

--

e47

cso30:c:Protein

cso30:i:CC_Extracellular

--

p51

p35 p44 p62 p72 p74 p76 p78 p80 p82 p83 p84

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
726.0, 1554.1211072664362
35.397923875432525, 18.878892733564015

IRF7

--

e48

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p50

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
862.5, 1356.3937677053825
18.461756373937675, 22.606232294617552

IRF-3{p}:pin1

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1225.5, 178.98433594400933
21.24612564572571, 26.015664055990666

TLR4:MD2

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
304.82207995667903, 1059.070808270325
734.2838679696748, 665.9147927397249

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
384.13020722342236, 1074.8520207704214
429.3577924440931, 645.4040701707397

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
314.3937504888722, 1067.9587880502181
715.1405269052889, 648.1388331799377

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
315.76113199347077, 1069.3261695548174
712.4057638960907, 645.4040701707397

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
304.82207995667903, 1059.070808270325
734.2838679696748, 665.9147927397249

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
304.82207995667903, 1059.070808270325
734.2838679696748, 665.9147927397249

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
315.76113199347077, 1069.3261695548174
712.4057638960907, 645.4040701707397

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
840.8356297594955, 1332.5471091901304
45.87402154504137, 41.52806160919543

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
720.5060573547815, 1523.9805198339939
129.90124293690718, 117.59480939551617

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
304.82207995667903, 1059.070808270325
734.2838679696748, 665.9147927397249

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1217.5, 221.64415489080562
21.038355661589282, 29.355845109194345

LPS:TLR4:MD2

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p10 p15 p86 p88 p95

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
477.8886561061861, 1354.9978396646275
23.253691181789215, 11.19622168012076

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
477.11214953615575, 1321.608057153337
79.59192342807519, 143.26546217053541

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
510.5019320474463, 1414.788845556937
12.42410512048001, 12.424105120480032

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
828.5, 1446.0246625562406
22.846525579070153, 27.97533744375937

IRF-3{p}{ub}:pin1

--

e63

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p39

p40

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1080.0, 892.2600000000002
32.31999999999999, 24.24

SARM

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1041.0, 563.1377540752666
29.7766150130811, 18.362245924733347

SIKE

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

p42

p41

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1173.5, 620.8623600660674
21.59864195265186, 30.13763993393284

IKK-i:SIKE:TBK1

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1091.0, 1142.1800000000003
25.759999999999994, 19.32

JAK

--

e67

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p43 p44

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1092.0, 1283.9000000000003
32.8, 24.599999999999998

JAK{active}

--

e68

cso30:c:Protein

cso30:i:CC_Extracellular

--

p43 p44

p45

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1101.0, 1596.2983425414363
21.331491712707184, 23.70165745856354

(stat1{p})2

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p47

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
90.48451733942059, 146.66878130862926
1182.2201889742587, 1675.175470723672

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
933.0, 1372.2983425414363
21.331491712707184, 23.70165745856354

(stat1{p})2

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
905.0, 1485.3598611468244
46.3769606582669, 13.140138853175623

(stat1{p})2:IRF1SBE DNA

--

e71

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p48

p37

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
881.0, 1409.9210665959142
53.441231095781376, 11.578933404085964

IRF1SBE

--

e72

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p48

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
690.0, 1590.048470043713
51.00539984571869, 14.451529956286965

IRF7 ISRE:ISGF3{act}

--

e73

cso30:c:Complex

cso30:i:CC_Nucleolus

--

p49

p50

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
566.0, 1621.5
60.0, 13.0

IRF7 ISRE

--

e74

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
845.0, 1561.5709342560556
38.304498269896186, 20.429065743944637

IRF1

--

e75

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
618.0, 1172.5259515570935
44.01384083044983, 23.47404844290657

IFN-alpha1

--

e76

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p52

p53

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
24.0, 1127.3989736365465
40.704367075870394, 25.10102636345341

IFN-alpha1

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
676.5, 266.53457757040496
22.430094984169305, 27.46542242959506

dsRNA:DDX58

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p56

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
953.5, 267.67422096317284
20.682719546742206, 25.32577903682719

dsRNA:IFIH1

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
94.70812138560751, 176.23400963193768
1134.1179143473048, 1646.7392116322876

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
549.5, 359.16847127913377
29.979262249954118, 41.83152872086622

dsRNA:DDX58:MAVS

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

p57

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
477.0, 473.794117647059
22.323529411764707, 37.20588235294118

dsRNA:DDX58:MAVS:IKK

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p58 p59

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
441.0, 705.0
30.0, 30.0

NF-kappaB

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p93 p94 p95 p96 p97 p98

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
265.5, 566.5262628295433
21.258804588448385, 34.473737170456836

IRF

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p59

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
414.5, 568.7645401489234
18.64520024149728, 30.235459851076676

IRF{active}

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

p59

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
555.0, 547.4405986903648
16.709073900841908, 38.55940130963518

DAI

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p60

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
531.0, 433.05524861878456
26.950276243093924, 29.94475138121547

DNA:DAI

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
534.0, 1314.5674740484433
36.43598615916955, 19.4325259515571

HLA-DR

--

e87

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p63

p64

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
94.0, 1193.8456501403182
19.566884939195507, 45.15434985968194

HLA-DR

--

e88

cso30:c:Protein

cso30:i:CC_Extracellular

--

p64

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
605.0, 1425.7923875432525
37.88927335640138, 20.20761245674741

CD54

--

e89

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p65

p66

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
105.9710655087726, 205.7992379552461
1128.9400439656276, 1625.1426395072413

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
416.0, 1816.9982893942442
47.840611793117326, 29.501710605755687

CD54

--

e90

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p66

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
661.0, 1505.9031141868513
37.681660899653984, 20.096885813148795

CD80

--

e91

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p67

p68

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
533.5, 1811.240893539948
20.20144898369893, 32.75910646005233

CD80

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

p68

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
466.0, 1461.3425605536331
34.982698961937714, 18.657439446366787

CD86

--

e93

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p70

p69

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
87.0, 1387.3400000000001
34.88, 26.160000000000004

CD86

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

p69

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
509.0, 1226.179930795848
37.16262975778547, 19.82006920415225

CXCL9

--

e95

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p71 p72

p73 p74

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
17.0, 1300.1449912126536
37.469244288224964, 24.355008787346218

CXCL9

--

e96

cso30:c:Protein

cso30:i:CC_Extracellular

--

p73 p74

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
430.0, 1566.40830449827
40.484429065743946, 21.591695501730104

CXCL10

--

e97

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p81 p82

p79 p80

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
501.0, 1483.446366782007
46.03806228373703, 24.553633217993077

CXCL11

--

e98

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p75 p76

p77 p78

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
15.5, 1661.8633527872812
17.967599114509962, 29.136647212718863

CXCL10

--

e99

cso30:c:Protein

cso30:i:CC_Cytosol

--

p79 p80

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1342.0, 182.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000016882

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m155666*0.1

nodelay

--

true

0

false

PMID: 18054516 TLR4 (together with its soluble coreceptor MD-2) binds Gram (¡Ý) bacteria-derived LPS

Go back
1327.0, 255.0
17.0, 17.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000041132

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m6*m19005*0.1

nodelay

--

true

0

false

--

Go back
1332.0, 356.0
15.0, 15.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 MO000041125

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m24*m18998*0.1

nodelay

--

true

0

false

PMID: 18054516, 16410796, 11544529 In the case of TLR4, another adaptor molecule, TRAM, is required to recruit TRIF to TLR4 and, in turn, to induce the pathway leading to the IFN-¦Â expression

Go back
918.0, 362.0
19.0, 19.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000042126

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m26*m19940*0.1

nodelay

--

true

0

false

PMID: 18054516, 11812998, 12032557, 15661881 In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice

Go back
663.0, 583.0
17.0, 17.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000042007

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m28*m19823*0.1

nodelay

--

true

0

false

PMID: 18054516, 11812998, 12032557, 15661881 In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice

Go back
863.0, 519.0
17.0, 17.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m19940*m28*0.1

nodelay

--

true

0

false

PMID: 18054516, 11812998, 12032557, 15661881 In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice

Go back
1140.0, 224.0
15.0, 15.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000016573

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
969.0, 45.0
21.0, 21.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000016573

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m18*m1572*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
1282.0, 70.0
19.0, 19.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000016573

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m11*m1572*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
902.0, 522.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000016573

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m19*m1572*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
814.0, 498.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000016573

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m21*m1572*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
1100.0, 28.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 e12

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m3964*m12*0.1

nodelay

--

true

0

false

PMID: 18054516 TLR2 recognizes peptidoglycan and lipopeptides

Go back
878.0, 630.0
19.0, 19.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016573

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m23*m1572*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
1058.0, 702.0
19.0, 19.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 MO000041437

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c63 : 1
stoichiometry:c62 : 1

m37*m19305*0.1

nodelay

--

true

0

false

PMID: 18054516, 12702806, 14517278 This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1

Go back
1114.0, 714.0
19.0, 19.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 e25

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1

m37*m25*0.1

nodelay

--

true

0

false

PMID: 18054516, 12702806, 14517278 This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1

Go back
1034.0, 878.0
19.0, 19.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e38

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c69 : 1
stoichiometry:c68 : 1

m977*m38*0.1

nodelay

--

true

0

false

PMID: 18054516, 12702806, 14517278 This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1

Go back
1139.0, 871.5
17.5, 17.5

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e38 e64

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c118 : 1
stoichiometry:c71 : 1

m980*m38*0.1

nodelay

--

true

0

false

PMID: 18054516, 16214811, 12821121 Recent reports have also shown that IRF-7 can be directly activated by TLR4 and TLR3 in IRF-3-deficient DC indicating that IRF-7 may potentiate the IRF-3-dependent induction of IFN-¦Â PMID: 18054516, 9786932, 9877175 Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation PMID: 18054516, 16964262 Carty et al. recently demonstrated that a TIR adaptor SARM inhibits TRIF-induced IRF-7 activation in TLR3 or TLR4-stimulated cells

Go back
945.0, 1018.0
21.0, 21.0

p25

p25

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041456

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18054516, 9786932, 9877175 Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation

Go back
1100.0, 1024.0
15.0, 15.0

p26

p26

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041457

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 18054516, 9786932, 9877175 Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation

Go back
797.0, 1302.0
17.0, 17.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e39 e40 MO000000058 MO000055971

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m39*m40*m41*m31298*0.1

nodelay

--

true

0

false

PMID: 18054516, 3329166, 16932750, 16979567 These events result in the assembly of the enhanceosome, a multiprotein complex consisting of ATF2/c-Jun, IRF-3/IRF-7, and NF-¦ÊB, all of which are required for the transcription of the IFN-¦Â gene

Go back
741.0, 1365.0
21.0, 21.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18054516, 3329166, 16932750, 16979567 These events result in the assembly of the enhanceosome, a multiprotein complex consisting of ATF2/c-Jun, IRF-3/IRF-7, and NF-¦ÊB, all of which are required for the transcription of the IFN-¦Â gene PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor

Go back
682.0, 974.0
19.0, 19.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e43 e31

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c85 : 1

m44*m31*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
1033.0, 81.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000019397

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m3964*0.1

nodelay

--

true

0

false

PMID: 18054516 TLR2 recognizes peptidoglycan and lipopeptides

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642.0, 978.0
19.0, 19.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e43 e34

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m44*m34*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

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718.0, 970.0
19.0, 19.0

p31

p31

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e43 e35

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c91 : 1

m44*m35*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

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746.0, 970.0
19.0, 19.0

p32

p32

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e43 e36

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m44*m36*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

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611.0, 951.0
17.0, 17.0

p33

p33

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e43 e32

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m44*m32*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
763.0, 911.0
17.0, 17.0

p34

p34

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e43 e33

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m44*m33*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 17048703 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
726.0, 1626.0
19.0, 19.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m48*m46*0.1

nodelay

--

true

0

false

PMID: 18054516, 9822609 While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-¦Á/¦Â through the activation of IFN-stimulated gene factor (ISGF)-3

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741.0, 1673.0
13.0, 13.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m45*m46*0.1

nodelay

--

true

0

false

PMID: 18054516, 9822609 While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-¦Á/¦Â through the activation of IFN-stimulated gene factor (ISGF)-3

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902.0, 1530.0
19.0, 19.0

p37

p37

cso30:i:ME_Transcription

cso30:i:CC_Cytosol

--

e71

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c146 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 18054516 Among these, IRF-1 and IRF-7 are transcriptionally regulated by SBE and ISRE sites present within their respective promoters.

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875.0, 1303.0
17.0, 17.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e39 MO000017197

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m39*m2065*0.1

nodelay

--

true

0

false

PMID: 18054516, 16699525 The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-¦Â production downstream of TLR3, TLR4 and RIG-I pathways

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821.0, 1409.0
21.0, 21.0

p39

p39

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 18054516, 16699525 The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-¦Â production downstream of TLR3, TLR4 and RIG-I pathways

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914.0, 62.0
20.0, 20.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019399 MO000022185

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c11 : 1

m3966*m6485*0.1

nodelay

--

true

0

false

PMID: 18054516 TLR5 recognizes flagellin

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849.0, 1505.0
21.0, 21.0

p40

p40

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e63

MO000019479 MO000017197

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18054516, 16699525 The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-¦Â production downstream of TLR3, TLR4 and RIG-I pathways

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1095.0, 587.0
17.0, 17.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m37*m66*0.1

nodelay

--

true

0

false

PMID: 18054516 Suppressor IKKvar epsilon (SIKE) is a suppressor that interacts with both TBK1 and IKKvar epsilon and sequester them in inactive complex.

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1162.0, 694.0
19.0, 19.0

p42

p42

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e66 MO000041446

e38 e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c125 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m67*m19314*0.1

nodelay

--

true

0

false

PMID: 18054516 Upon viral infection or TLR3 triggering, SIKE dissociates from TBK1 and IKKvar epsilon allowing type I IFN gene expression.

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1116.0, 1212.0
15.0, 15.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m45*m68*0.1

nodelay

--

true

0

false

PMID: 18054516, 10817963 Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs)

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1075.0, 1211.0
17.0, 17.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m48*m68*0.1

nodelay

--

true

0

false

PMID: 18054516, 10817963 Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs)

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1094.0, 1422.0
19.0, 19.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e68

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c134 : 1
stoichiometry:c133 : 1

m1357*m69*0.1

nodelay

--

true

0

false

PMID: 18054516, 10817963 Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs) PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.

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1102.0, 1514.0
19.0, 19.0

p46

p46

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000019704

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.

Go back
1054.0, 1598.0
19.0, 19.0

p47

p47

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.

Go back
937.0, 1437.0
21.0, 21.0

p48

p48

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e70 e72

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c141 : 1
stoichiometry:c140 : 1

m71*m73*0.1

nodelay

--

true

0

false

PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.

Go back
662.0, 1618.5
19.5, 19.5

p49

p49

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e46 e74

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m47*m75*0.1

nodelay

--

true

0

false

PMID: 18054516 Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-¦Ã activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.

Go back
862.0, 386.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e20

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m19940*m20*0.1

nodelay

--

true

0

false

PMID: 18054516, 14976261, 14976262 TLR7 and TLR8 recognize single-strand (ss)RNA and are also activated by infections with ssRNA viruses, including influenza virus and vesicular stomatitis virus

Go back
654.0, 1554.0
19.0, 19.0

p50

p50

cso30:i:ME_Transcription

cso30:i:CC_Cytosol

--

e73

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c145 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 18054516, 9822609 While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-¦Á/¦Â through the activation of IFN-stimulated gene factor (ISGF)-3 PMID: 18054516 Among these, IRF-1 and IRF-7 are transcriptionally regulated by SBE and ISRE sites present within their respective promoters

Go back
985.0, 1293.0
21.0, 21.0

p51

p51

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e42

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor

Go back
690.0, 1174.0
19.0, 19.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e39

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c149 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor

Go back
410.0, 1130.0
19.0, 19.0

p53

p53

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 18054516, 12077266, 14991609 In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-¦Â and a poor production of IFN-¦Á1 from human myeloid DC PMID: 18054516, 12077266, 14991609, 16846591 In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-¦Â and IFN-¦Á1 which contain in their promoter specific sequences recognizing this transcription factor

Go back
829.0, 233.0
21.0, 21.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000066987

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m119368*m41844*0.1

nodelay

--

true

0

false

PMID: 18054516 During a viral infection, RIG-1 and MDA5 are activated upon detection of dsRNA by the RNA helicase domain, and trigger the activation of NF-¦ÊB and IRF3/7, which cooperate in the induction of type I IFNs

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859.0, 271.0
17.0, 17.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000103999

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 18054516 During a viral infection, RIG-1 and MDA5 are activated upon detection of dsRNA by the RNA helicase domain, and trigger the activation of NF-¦ÊB and IRF3/7, which cooperate in the induction of type I IFNs

Go back
589.0, 305.0
21.0, 21.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e78 MO000094908

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c161 : 1
stoichiometry:c160 : 1

m79*m68199*0.1

nodelay

--

true

0

false

PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation

Go back
482.0, 386.0
19.0, 19.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e80 MO000000248

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m81*m207*0.1

nodelay

--

true

0

false

PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation

Go back
497.0, 605.0
21.0, 21.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e81

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1

m83*m82*0.1

nodelay

--

true

0

false

PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation

Go back
339.0, 575.0
17.0, 17.0

p59

p59

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e83 e81

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c170 : 1
stoichiometry:c169 : 1

m84*m82*0.1

nodelay

--

true

0

false

PMID: 18054516, 16177806, 16125763, 16127453, 16039576 It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-¦ÊB and IRF activation

Go back
798.0, 378.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19823*m20*0.1

nodelay

--

true

0

false

PMID: 18054516, 14976261, 14976262 TLR7 and TLR8 recognize single-strand (ss)RNA and are also activated by infections with ssRNA viruses, including influenza virus and vesicular stomatitis virus

Go back
612.0, 440.0
15.0, 15.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1
stoichiometry:c173 : 1

m22*m86*0.1

nodelay

--

true

0

false

PMID: 18054516, 17618271 The very recent identification of DNA-dependent activator of IRF (DAI) as a cytosolic DNA sensor able to induce type I IFN expression following the recognition of different sources of microbial DNA, provides an explanation of how different pathogens may induce type I IFN genes through a unique pathway

Go back
1498.0, 1262.0
19.0, 19.0

p61

p61

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e44

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 type I IFNs promote the differentiation of human blood monocytes into DC and contribute to their maturation

Go back
1503.0, 1423.0
17.0, 17.0

p62

p62

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e47

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 type I IFNs promote the differentiation of human blood monocytes into DC and contribute to their maturation

Go back
595.0, 1283.0
17.0, 17.0

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c178 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
327.0, 1171.0
17.0, 17.0

p64

p64

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e87 e44

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c180 : 1
stoichiometry:c176 : 1

m88*m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
614.0, 1362.0
19.0, 19.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
431.0, 1711.0
17.0, 17.0

p66

p66

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e89 e44

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c185 : 1
stoichiometry:c181 : 1

m90*m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
669.0, 1444.5
22.5, 22.5

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c186 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
533.0, 1757.0
21.0, 21.0

p68

p68

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e91 e44

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c190 : 1
stoichiometry:c188 : 1

m92*m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
252.0, 1392.0
15.0, 15.0

p69

p69

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e93 e44

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c193 : 1
stoichiometry:c192 : 1

m94*m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
994.0, 462.0
19.0, 19.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18054516 TLR3 is triggered by double-strand (ds)RNA.

Go back
501.0, 1393.0
21.0, 21.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c194 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516, 15101709, 16769767, 12513906 In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-¦Á express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54

Go back
671.0, 1227.0
17.0, 17.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
646.0, 1258.0
19.0, 19.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
274.0, 1250.0
19.0, 19.0

p73

p73

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e95 e44

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c204 : 1
stoichiometry:c200 : 1

m96*m45*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
273.0, 1329.0
21.0, 21.0

p74

p74

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e95 e47

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c205 : 1
stoichiometry:c201 : 1

m96*m48*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
514.0, 1446.0
19.0, 19.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c206 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
562.0, 1462.0
19.0, 19.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e47

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c207 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
254.0, 1478.0
19.0, 19.0

p77

p77

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e98 e44

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c220 : 1
stoichiometry:c208 : 1

m99*m45*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
251.0, 1559.0
17.0, 17.0

p78

p78

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e98 e47

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c224 : 1
stoichiometry:c209 : 1

m99*m48*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
263.0, 1591.0
17.0, 17.0

p79

p79

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e97 e44

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c221 : 1
stoichiometry:c212 : 1

m98*m45*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
692.0, 468.0
15.0, 15.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19828*m22*0.1

nodelay

--

true

0

false

PMID: 18054516 TLR9 is known to bind unmethylated bacterial and viral dsDNA

Go back
271.0, 1679.0
17.0, 17.0

p80

p80

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e97 e47

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c215 : 1
stoichiometry:c225 : 1
stoichiometry:c213 : 1

m98*m48*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
593.0, 1501.0
21.0, 21.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c216 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
586.0, 1550.0
19.0, 19.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c217 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18054516 In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.

Go back
458.0, 1318.0
19.0, 19.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47 e103

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1
stoichiometry:c226 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 18054516, 10604988 On the other hand, CD40-dependent IL-12 production from monocyte-derived DC was shown to be impaired by IFN-¦Â

Go back
243.0, 1283.0
17.0, 17.0

p84

p84

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e101 e47 e103

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c229 : 1
stoichiometry:c232 : 1
stoichiometry:c228 : 1

m102*m104*0.1

nodelay

--

true

0

false

PMID: 18054516, 10604988 On the other hand, CD40-dependent IL-12 production from monocyte-derived DC was shown to be impaired by IFN-¦Â

Go back
990.0, 1178.0
19.0, 19.0

p85

p85

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e104 MO000041446

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c238 : 1
stoichiometry:c234 : 1

m105*m19314*0.1

nodelay

--

true

0

false

PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C

Go back
1025.0, 1121.0
21.0, 21.0

p86

p86

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e104 e6

MO000013119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c237 : 1
stoichiometry:c233 : 1

m105*m6*0.1

nodelay

--

true

0

false

PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C

Go back
547.0, 1035.0
17.0, 17.0

p87

p87

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011682 MO000041446

MO000013120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c244 : 1
stoichiometry:c241 : 1

m94507*m19314*0.1

nodelay

--

true

0

false

PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C

Go back
583.0, 1015.0
17.0, 17.0

p88

p88

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011682 e6

MO000013120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c243 : 1
stoichiometry:c242 : 1

m94507*m6*0.1

nodelay

--

true

0

false

PMID: 18054516, 16624932 Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C

Go back
773.0, 1097.0
21.0, 21.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000000058

G011698

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
1047.0, 527.0
17.0, 17.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18054516, 11544529, 16410796 With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-¦ÊB

Go back
860.0, 1008.0
15.0, 15.0

p90

p90

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011698

MO000017181

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1

m94523*0.1

nodelay

--

true

0

false

PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
858.0, 950.0
19.0, 19.0

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017181 e44

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c251 : 1
stoichiometry:c250 : 1

m2053*m45*0.1

nodelay

--

true

0

false

PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
591.0, 1127.0
17.0, 17.0

p92

p92

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e105

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m106*0.1

nodelay

--

true

0

false

PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
510.0, 666.0
19.0, 19.0

p93

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e11

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c256 : 1
stoichiometry:c255 : 1

m83*m11*0.1

nodelay

--

true

0

false

PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
609.0, 685.0
21.0, 21.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 MO000041446

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c259 : 1
stoichiometry:c258 : 1

m83*m19314*0.1

nodelay

--

true

0

false

PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
535.0, 739.0
17.0, 17.0

p95

p95

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e6

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c262 : 1
stoichiometry:c261 : 1

m83*m6*0.1

nodelay

--

true

0

false

PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
502.0, 762.0
19.0, 19.0

p96

p96

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 MO000000289

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c265 : 1
stoichiometry:c264 : 1

m83*m230*0.1

nodelay

--

true

0

false

PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
494.0, 842.0
19.0, 19.0

p97

p97

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e107

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c268 : 1
stoichiometry:c267 : 1

m83*m108*0.1

nodelay

--

true

0

false

PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
558.0, 862.0
19.0, 19.0

p98

p98

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e108

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c271 : 1
stoichiometry:c270 : 1

m83*m109*0.1

nodelay

--

true

0

false

PMID: 18054516 STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-¦ÊB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-¦Á and IL-1¦Â. PMID: 18054516 Thus, under inflammatory conditions, NF-¦ÊB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.

Go back
1247.0, 192.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.5372262238147, 89.1755160540241

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.4587851581927, 928.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0545049220716, 183.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.449942237646, 1641.9151947886442

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.9088269514548, 1645.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.4139141457872, 1663.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.9382230137094, 1681.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.7695049540179, 1278.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.6791803739482, 1449.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
917.6752787613661, 1499.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
679.7839864320407, 1574.2399915200253

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.2960811950677, 82.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.0, 1281.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.0, 1316.1570394041598

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.7354436625493, 1320.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
844.8674523492571, 1379.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.0, 1430.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.0, 1474.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
833.3535288407921, 1526.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.8374782761443, 1341.9560436233712

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1112.0, 885.6245538642138

c118

c118

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1104.0, 612.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 72.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.0, 579.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1112.0, 600.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1175.2854048166537, 651.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1110.9619305082008, 713.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1069.2718057815605, 587.0173136698619

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.0, 578.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1138.8674808144253, 1222.4500846991293

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1098.4698886744254, 1230.7053735814004

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1089.197769023179, 1162.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.0, 1228.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 413.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.0, 1162.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.6480838483988, 1227.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1071.0, 1320.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.79887605359, 1441.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1104.2830085864284, 1309.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1100.0, 1482.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1112.0, 1533.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1081.0, 1608.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.7990323588295, 1403.0404085915923

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.0, 1396.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 405.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.2491077284276, 1458.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 1422.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.2950039375453, 1644.7492919018569

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 1609.5685159055888

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.0, 1628.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 1564.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
886.6098187424603, 1547.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.0, 1314.0731013120605

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 1308.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 1184.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 342.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.2447724594695, 1191.3931212784858

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.8430452850579, 1143.5769085758318

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
73.0, 1140.0

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 244.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
713.0, 237.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.795129565557, 247.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.2469504755443, 257.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.5210885212998, 248.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 280.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.42015115468, 285.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.3151918984429, 404.89115139065717

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.8308170454446, 326.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 313.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.80573001674856, 383.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 322.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.3474977942105, 405.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.0, 633.1734860663945

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.0, 626.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.0, 511.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
287.0, 584.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 584.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.0545840621533, 342.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
362.6733233562934, 499.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.8623479330104, 403.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 462.2157741863865

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 448.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1410.0, 1270.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1409.0, 1433.7624706187337

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
121.90568189827019, 1181.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
350.6458429853825, 1189.4533999386583

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
574.769862720718, 1298.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.9967703134449, 1270.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.6168845110653, 397.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.97162248792347, 1181.6732272350646

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
440.0, 1728.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
450.35545550844347, 1446.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.0, 1381.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
640.9317418803018, 1272.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
455.24274389863245, 1276.0

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 1467.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.7437743567938, 1273.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 1778.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.8073212077064, 1526.0

c189

c189

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 260.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.9114360610712, 1277.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
274.6158301993228, 1404.4493122249078

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
130.0, 1400.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.9481697641055, 1271.0

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
490.2635204975204, 1414.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.9109527292533, 1272.0

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.9910741472439, 1236.3778014997981

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
554.0, 1236.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.7800919753217, 1271.8628389236685

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
553.7611400011626, 1241.9402850002907

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1368.8911513906571, 194.31519189844286

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0, 487.42845754675795

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
61.830656805177654, 1262.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
61.948378298304846, 1314.907349120811

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
300.9624572941336, 1238.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.35492851053056, 1244.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
300.99966519463896, 1260.0731899834825

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
301.96530880409915, 1341.7442147911322

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 1465.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.2494651199621, 1477.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
70.49866966349495, 1492.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
71.0, 1568.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
997.6465269501284, 481.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.9962322724899, 1488.2454983592431

c210

c210

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
275.7142776488628, 1502.0

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
40.653391043430865, 1603.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
40.98985057386662, 1676.4028496087665

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
287.9365843121409, 1580.0

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
294.691689036638, 1588.0

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.3899369085731, 1517.0

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.94236490407974, 1561.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
540.8257601166949, 1273.0

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.6532709728074, 1274.0

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
714.5693118796269, 480.58950143250394

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.8561019173624, 1272.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
287.67735131139983, 1274.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.9953786371444, 1445.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.9152208916661, 1446.0

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
275.9526341753226, 1446.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
295.8148716816116, 1448.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
407.0, 1328.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
267.7037121577134, 1296.1570394041598

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
49.45812446414977, 1296.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.9647561550583, 1293.52981943238

c229

c229

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
678.0, 403.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
480.9687022121455, 1329.4994023941786

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
301.0, 1344.576849668604

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
253.64282825233718, 1307.974131415897

c232

c232

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1038.0, 1142.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1005.0, 1197.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 1137.4090509434968

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
892.0, 1185.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1039.6811440301656, 251.0

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
996.0, 581.0

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.2334286249152, 1038.7880838296053

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 483.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
569.9637651601156, 1056.332307672574

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
491.51950036023965, 976.7909511976285

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.9726042969964, 968.9220899170605

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.028209338764, 249.0

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
569.4326843772308, 581.0

c244

c244

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
727.0, 1105.0

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
794.0, 1115.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
843.0, 1030.8224193126193

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
875.0, 1016.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.4829175920399, 974.8255999415425

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 544.7259714626609

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 924.5183473879075

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.9038272797037, 969.041926383795

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
614.2195860527598, 914.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
555.0, 1136.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 687.5536798306425

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 685.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0199487732172, 177.0

c256

c256

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
471.0, 699.1474325785512

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 706.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.5677554664985, 572.0

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1072.0, 536.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.0, 725.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 753.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.4069197365154, 244.0

c262

c262

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
471.0, 734.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 775.0

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
41.0, 772.2081724353018

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.0, 735.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 824.5578318433052

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
57.0, 848.0

c268

c268

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.0, 735.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1013.3229641980356, 544.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.0, 831.8102651883261

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
59.0, 875.1890493410456

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1239.0, 239.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1192.0, 264.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1246.5520092255726, 196.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1247.4219155590922, 268.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1240.0, 314.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1161.0, 376.3343588757586

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1266.0, 364.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
945.0, 372.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
881.0, 387.63960941474

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
929.0, 381.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.0, 538.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.8912650667165, 472.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 592.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1118.785492236829, 58.49940217607812

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 469.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 528.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
791.3107368602815, 536.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1162.9909451017954, 232.3805211953236

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1045.0, 236.40905094349677

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.8446454055273, 172.56892908110547

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
918.0, 72.72691443834488

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.9402850002907, 73.76114000116266

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0785288682105, 62.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1110.0, 88.30403934784556

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1102.7316151395657, 51.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.0, 91.69887370880342

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1234.4057970281387, 89.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 496.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.2967451569431, 281.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.428103759208, 541.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
790.0, 477.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.2383834243369, 281.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
773.9494575627491, 517.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
774.0, 555.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.886153425135, 281.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1131.0, 40.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.0, 640.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1079.5418636464292, 673.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.0, 721.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1005.0, 618.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1108.0, 673.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1106.0457559976994, 733.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.6184485159733, 382.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1034.0, 826.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1044.0, 897.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1051.2988591893932, 783.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1044.0, 28.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1148.0, 823.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1148.0, 889.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1101.0, 783.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
971.7445414019716, 956.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.4343650876585, 1039.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1115.528950800577, 965.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
867.4418013519901, 1038.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.9055008250352, 1275.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.5334722010213, 1237.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.0, 1119.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.710809234344, 103.35488684356363

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
749.0, 1311.1666305094548

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 1319.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.0, 1376.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 1386.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
667.0, 835.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
694.0, 993.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.3461336235019, 189.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.5580776638293, 835.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 997.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.9434236786027, 700.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1044.0, 102.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 835.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
715.031321842037, 989.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.2458726331645, 748.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
673.0, 835.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.7097557461819, 989.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.8640759600445, 654.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.3711937189796, 835.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.0, 968.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.4699635266591, 186.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
679.0, 834.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back