_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e3
_enti_e2
_enti_e4
_enti_e15
_enti_e55
_enti_e17
_enti_e16
_enti_e59
_enti_e53
_enti_e52
_enti_e50
_enti_e51
_enti_e54
_enti_e56
_enti_e57
_enti_e61
_enti_e58
_enti_e60
_enti_e62
g1_fact_g3
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g1
p1_propro_p1
PMID: 18054516
TLR4 (together with its soluble coreceptor MD-2) binds Gram () bacteria-derived LPS
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18054516
TLR2 recognizes peptidoglycan and lipopeptides
c4 cso30:c:InputProcess connector
c6 cso30:c:InputProcess connector
c5 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18054516
TLR2 recognizes peptidoglycan and lipopeptides
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18054516
TLR5 recognizes flagellin
c10 cso30:c:InputProcess connector
c12 cso30:c:InputProcess connector
c11 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 18054516, 14976261, 14976262
TLR7 and TLR8 recognize single-strand (ss)RNA and are also activated by infections with ssRNA viruses, including influenza virus and vesicular stomatitis virus
c13 cso30:c:InputProcess connector
c15 cso30:c:InputProcess connector
c14 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18054516, 14976261, 14976262
TLR7 and TLR8 recognize single-strand (ss)RNA and are also activated by infections with ssRNA viruses, including influenza virus and vesicular stomatitis virus
c16 cso30:c:InputProcess connector
c17 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 18054516
TLR3 is triggered by double-strand (ds)RNA.
c19 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
c21 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18054516
TLR9 is known to bind unmethylated bacterial and viral dsDNA
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18054516, 11544529, 16410796
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c27 cso30:c:OutputProcess connector
p10_propro_p10
c28 cso30:c:InputProcess connector
c29 cso30:c:InputProcess connector
c30 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 18054516, 16410796, 11544529
In the case of TLR4, another adaptor molecule, TRAM, is required to recruit TRIF to TLR4 and, in turn, to induce the pathway leading to the IFN-β expression
c31 cso30:c:InputProcess connector
c32 cso30:c:InputProcess connector
c33 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18054516, 11812998, 12032557, 15661881
In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c36 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 18054516, 11812998, 12032557, 15661881
In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice
c37 cso30:c:InputProcess connector
c38 cso30:c:InputProcess connector
c39 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18054516, 11812998, 12032557, 15661881
In addition to ssRNA, the synthetic imidazoquinoline, imiquimod, a low molecular weight immune response modifier, activates TLR7 in both humans and mice while its derivative resiquimod (R-848) activates TLR7 and TLR8 in humans, but only TLR7 in mice
c40 cso30:c:InputProcess connector
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c43 cso30:c:InputProcess connector
c44 cso30:c:InputProcess connector
c45 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c46 cso30:c:InputProcess connector
c47 cso30:c:InputProcess connector
c48 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c49 cso30:c:InputProcess connector
c50 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c52 cso30:c:InputProcess connector
c53 cso30:c:InputProcess connector
c54 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c55 cso30:c:InputProcess connector
c56 cso30:c:InputProcess connector
c57 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c58 cso30:c:InputProcess connector
c59 cso30:c:InputProcess connector
c60 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 18054516, 12702806, 14517278
This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1
c61 cso30:c:InputProcess connector
c63 cso30:c:InputAssociation connector
c62 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 18054516, 12702806, 14517278
This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1
c64 cso30:c:InputProcess connector
c66 cso30:c:InputAssociation connector
c65 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 18054516, 12702806, 14517278
This pathway mainly mediates the phosphorylation-induced activation of IRF-3 by two IkB kinase-related kinases, inhibitory protein kB kinase (IKK)-var epsilon and TANK binding kinase (TBK)1
c67 cso30:c:InputProcess connector
c69 cso30:c:InputAssociation connector
c68 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 18054516, 16214811, 12821121
Recent reports have also shown that IRF-7 can be directly activated by TLR4 and TLR3 in IRF-3-deficient DC indicating that IRF-7 may potentiate the IRF-3-dependent induction of IFN-β
PMID: 18054516, 9786932, 9877175
Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation
PMID: 18054516, 16964262
Carty et al. recently demonstrated that a TIR adaptor SARM inhibits TRIF-induced IRF-7 activation in TLR3 or TLR4-stimulated cells
c70 cso30:c:InputProcess connector
c72 cso30:c:InputAssociation connector
c118 cso30:c:InputInhibitor connector
c71 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 18054516, 9786932, 9877175
Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation
c73 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18054516, 9786932, 9877175
Similar to IRF-3, IRF-7 undergoes serine phosphorylation by IKK-var epsilon and TBK1 followed by nuclear translocation
c75 cso30:c:InputProcess connector
c76 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 18054516, 3329166, 16932750, 16979567
These events result in the assembly of the enhanceosome, a multiprotein complex consisting of ATF2/c-Jun, IRF-3/IRF-7, and NF-κB, all of which are required for the transcription of the IFN-β gene
c77 cso30:c:InputProcess connector
c78 cso30:c:InputProcess connector
c79 cso30:c:InputProcess connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 18054516, 3329166, 16932750, 16979567
These events result in the assembly of the enhanceosome, a multiprotein complex consisting of ATF2/c-Jun, IRF-3/IRF-7, and NF-κB, all of which are required for the transcription of the IFN-β gene
PMID: 18054516, 12077266, 14991609
In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-β and a poor production of IFN-α1 from human myeloid DC
PMID: 18054516, 12077266, 14991609, 16846591
In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-β and IFN-α1 which contain in their promoter specific sequences recognizing this transcription factor
c82 cso30:c:InputAssociation connector
c83 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c84 cso30:c:InputProcess connector
c86 cso30:c:InputAssociation connector
c85 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c87 cso30:c:InputProcess connector
c89 cso30:c:InputAssociation connector
c88 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c90 cso30:c:InputProcess connector
c92 cso30:c:InputAssociation connector
c91 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c93 cso30:c:InputProcess connector
c95 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c96 cso30:c:InputProcess connector
c98 cso30:c:InputAssociation connector
c97 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 18054516, 11544529, 17048703
With the exception of TLR3, which signals solely by TRIF, all TLRs recruit MyD88, which triggers signalling pathways leading to nuclear translocation of NF-κB
c99 cso30:c:InputProcess connector
c101 cso30:c:InputAssociation connector
c100 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18054516, 9822609
While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-α/β through the activation of IFN-stimulated gene factor (ISGF)-3
c107 cso30:c:InputAssociation connector
c102 cso30:c:InputProcess connector
c103 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 18054516, 9822609
While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-α/β through the activation of IFN-stimulated gene factor (ISGF)-3
c106 cso30:c:InputAssociation connector
c104 cso30:c:InputProcess connector
c105 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 18054516, 16699525
The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-β production downstream of TLR3, TLR4 and RIG-I pathways
c110 cso30:c:InputProcess connector
c111 cso30:c:InputProcess connector
c112 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 18054516, 16699525
The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-β production downstream of TLR3, TLR4 and RIG-I pathways
c113 cso30:c:InputProcess connector
c114 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 18054516, 16699525
The peptidyl prolyl isomerase Pin1 interacts with IRF-3 in the nucleus and facilitates the conjugation of polyubiquitin and the proteasome-dependent degradation of IRF-3, thereby blocking the IFN-β production downstream of TLR3, TLR4 and RIG-I pathways
c115 cso30:c:InputProcess connector
c116 cso30:c:OutputProcess connector
c117 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 18054516
Suppressor IKKvar epsilon (SIKE) is a suppressor that interacts with both TBK1 and IKKvar epsilon and sequester them in inactive complex.
c119 cso30:c:InputProcess connector
c120 cso30:c:InputProcess connector
c121 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 18054516
Upon viral infection or TLR3 triggering, SIKE dissociates from TBK1 and IKKvar epsilon allowing type I IFN gene expression.
c122 cso30:c:InputProcess connector
c125 cso30:c:InputAssociation connector
c123 cso30:c:OutputProcess connector
c124 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 18054516, 10817963
Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs)
c126 cso30:c:InputAssociation connector
c130 cso30:c:InputProcess connector
c131 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 18054516, 10817963
Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs)
c127 cso30:c:InputAssociation connector
c128 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 18054516, 10817963
Once secreted from infected cells, IFNs induce in an autocrine and paracrine fashion the activation of Janus kinases (JAKs) and STAT transcription factors, leading to expression of IFN-stimulated genes (ISGs)
PMID: 18054516
Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-γ activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
c132 cso30:c:InputProcess connector
c134 cso30:c:InputAssociation connector
c133 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 18054516
Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-γ activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
c135 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 18054516
Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-γ activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
c137 cso30:c:InputProcess connector
c138 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 18054516
Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-γ activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
c139 cso30:c:InputProcess connector
c141 cso30:c:InputProcess connector
c140 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 18054516
Upon phosphorylation and translocation into the nucleus, STAT bind as STAT-1 homodimer (GAF, IFN-γ activated factor) to STAT binding element (SBE) or as heterotrimeric ISGF-3 complex (consisting of IRF-9, STAT-1 and STAT-2) to the IFN-stimulated response element (ISRE) in the promoter of target genes.
c142 cso30:c:InputProcess connector
c144 cso30:c:InputProcess connector
c143 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 18054516, 9822609
While IRF-3 is constitutively expressed, IRF-7 expression is induced by IFN-α/β through the activation of IFN-stimulated gene factor (ISGF)-3
PMID: 18054516
Among these, IRF-1 and IRF-7 are transcriptionally regulated by SBE and ISRE sites present within their respective promoters
c109 cso30:c:InputAssociation connector
c145 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 18054516
Among these, IRF-1 and IRF-7 are transcriptionally regulated by SBE and ISRE sites present within their respective promoters.
c108 cso30:c:InputAssociation connector
c146 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 18054516, 12077266, 14991609
In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-β and a poor production of IFN-α1 from human myeloid DC
PMID: 18054516, 12077266, 14991609, 16846591
In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-β and IFN-α1 which contain in their promoter specific sequences recognizing this transcription factor
c147 cso30:c:InputAssociation connector
c148 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 18054516, 12077266, 14991609
In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-β and a poor production of IFN-α1 from human myeloid DC
PMID: 18054516, 12077266, 14991609, 16846591
In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-β and IFN-α1 which contain in their promoter specific sequences recognizing this transcription factor
c150 cso30:c:InputAssociation connector
c149 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 18054516, 12077266, 14991609
In particular, the stimulation of TLR3 and TLR4 is associated mainly with the release of IFN-β and a poor production of IFN-α1 from human myeloid DC
PMID: 18054516, 12077266, 14991609, 16846591
In myeloid DC the activation of IRF-3 following TLR3 or TLR4 triggering is responsible for the selective expression of IFN-β and IFN-α1 which contain in their promoter specific sequences recognizing this transcription factor
c151 cso30:c:InputAssociation connector
c152 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 18054516
During a viral infection, RIG-1 and MDA5 are activated upon detection of dsRNA by the RNA helicase domain, and trigger the activation of NF-κB and IRF3/7, which cooperate in the induction of type I IFNs
c153 cso30:c:InputProcess connector
c154 cso30:c:InputProcess connector
c155 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 18054516
During a viral infection, RIG-1 and MDA5 are activated upon detection of dsRNA by the RNA helicase domain, and trigger the activation of NF-κB and IRF3/7, which cooperate in the induction of type I IFNs
c156 cso30:c:InputProcess connector
c157 cso30:c:InputProcess connector
c158 cso30:c:OutputProcess connector
p56_propro_p56
PMID: 18054516, 16177806, 16125763, 16127453, 16039576
It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-κB and IRF activation
c159 cso30:c:InputProcess connector
c161 cso30:c:InputProcess connector
c160 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 18054516, 16177806, 16125763, 16127453, 16039576
It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-κB and IRF activation
c162 cso30:c:InputProcess connector
c163 cso30:c:InputProcess connector
c164 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 18054516, 16177806, 16125763, 16127453, 16039576
It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-κB and IRF activation
c165 cso30:c:InputProcess connector
c167 cso30:c:InputAssociation connector
c166 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 18054516, 16177806, 16125763, 16127453, 16039576
It has been proposed that once activated by dsRNA, RIG-I interacts with IPS-1 via their respective CARD domains, resulting in the recruitment of appropriate signalling intermediates, such as IKKs for NF-κB and IRF activation
c168 cso30:c:InputProcess connector
c170 cso30:c:InputAssociation connector
c169 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 18054516, 17618271
The very recent identification of DNA-dependent activator of IRF (DAI) as a cytosolic DNA sensor able to induce type I IFN expression following the recognition of different sources of microbial DNA, provides an explanation of how different pathogens may induce type I IFN genes through a unique pathway
c171 cso30:c:InputProcess connector
c172 cso30:c:InputProcess connector
c173 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 18054516, 15101709, 16769767, 12513906
type I IFNs promote the differentiation of human blood monocytes into DC and contribute to their maturation
c174 cso30:c:InputAssociation connector
p62_propro_p62
PMID: 18054516, 15101709, 16769767, 12513906
type I IFNs promote the differentiation of human blood monocytes into DC and contribute to their maturation
c175 cso30:c:InputAssociation connector
p63_propro_p63
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c179 cso30:c:InputAssociation connector
c178 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c177 cso30:c:InputAssociation connector
c180 cso30:c:InputAssociation connector
c176 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c184 cso30:c:InputAssociation connector
c183 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c182 cso30:c:InputAssociation connector
c185 cso30:c:InputAssociation connector
c181 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c187 cso30:c:InputAssociation connector
c186 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c189 cso30:c:InputAssociation connector
c190 cso30:c:InputAssociation connector
c188 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c191 cso30:c:InputAssociation connector
c193 cso30:c:InputAssociation connector
c192 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 18054516, 15101709, 16769767, 12513906
In particular, it was reported that blood monocytes maintained in culture for 3 days with IFN-α express high levels of HLA-DR, of costimulatory molecules CD80, CD86 and of adhesion molecule CD54
c195 cso30:c:InputAssociation connector
c194 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c196 cso30:c:InputAssociation connector
c197 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c198 cso30:c:InputAssociation connector
c199 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c202 cso30:c:InputAssociation connector
c204 cso30:c:InputAssociation connector
c200 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c203 cso30:c:InputAssociation connector
c205 cso30:c:InputAssociation connector
c201 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c218 cso30:c:InputAssociation connector
c206 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c222 cso30:c:InputAssociation connector
c207 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c210 cso30:c:InputAssociation connector
c220 cso30:c:InputAssociation connector
c208 cso30:c:OutputProcess connector
p78_propro_p78
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c211 cso30:c:InputAssociation connector
c224 cso30:c:InputAssociation connector
c209 cso30:c:OutputProcess connector
p79_propro_p79
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c214 cso30:c:InputAssociation connector
c221 cso30:c:InputAssociation connector
c212 cso30:c:OutputProcess connector
p80_propro_p80
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c215 cso30:c:InputAssociation connector
c225 cso30:c:InputAssociation connector
c213 cso30:c:OutputProcess connector
p81_propro_p81
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c219 cso30:c:InputAssociation connector
c216 cso30:c:OutputProcess connector
p82_propro_p82
PMID: 18054516
In particular, the expression of CXCR3 binding chemokines, CXCL9, CXCL10 and CXCL11, is dependent on type I IFNs.
c223 cso30:c:InputAssociation connector
c217 cso30:c:OutputProcess connector
p83_propro_p83
PMID: 18054516, 10604988
On the other hand, CD40-dependent IL-12 production from monocyte-derived DC was shown to be impaired by IFN-β
c230 cso30:c:InputInhibitor connector
c231 cso30:c:InputAssociation connector
c226 cso30:c:OutputProcess connector
p84_propro_p84
PMID: 18054516, 10604988
On the other hand, CD40-dependent IL-12 production from monocyte-derived DC was shown to be impaired by IFN-β
c227 cso30:c:InputAssociation connector
c229 cso30:c:InputInhibitor connector
c232 cso30:c:InputAssociation connector
c228 cso30:c:OutputProcess connector
p85_propro_p85
PMID: 18054516, 16624932
Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
c236 cso30:c:InputAssociation connector
c238 cso30:c:InputAssociation connector
c234 cso30:c:OutputProcess connector
p86_propro_p86
PMID: 18054516, 16624932
Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
c235 cso30:c:InputAssociation connector
c237 cso30:c:InputAssociation connector
c233 cso30:c:OutputProcess connector
p87_propro_p87
PMID: 18054516, 16624932
Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
c240 cso30:c:InputAssociation connector
c244 cso30:c:InputAssociation connector
c241 cso30:c:OutputProcess connector
p88_propro_p88
PMID: 18054516, 16624932
Among the STAT transcription factors involved in type I IFN signalling, STAT-1 and -2 contents are increased in DC stimulated with LPS or poly I:C
c239 cso30:c:InputAssociation connector
c243 cso30:c:InputAssociation connector
c242 cso30:c:OutputProcess connector
p89_propro_p89
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c245 cso30:c:InputAssociation connector
c246 cso30:c:OutputProcess connector
p90_propro_p90
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c247 cso30:c:InputAssociation connector
c248 cso30:c:OutputProcess connector
p91_propro_p91
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c249 cso30:c:InputProcess connector
c251 cso30:c:InputAssociation connector
c250 cso30:c:OutputProcess connector
p92_propro_p92
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c252 cso30:c:InputAssociation connector
c253 cso30:c:OutputProcess connector
p93_propro_p93
PMID: 18054516
STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-κB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-α and IL-1β.
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c254 cso30:c:InputProcess connector
c256 cso30:c:InputAssociation connector
c255 cso30:c:OutputProcess connector
p94_propro_p94
PMID: 18054516
STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-κB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-α and IL-1β.
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c257 cso30:c:InputProcess connector
c259 cso30:c:InputAssociation connector
c258 cso30:c:OutputProcess connector
p95_propro_p95
PMID: 18054516
STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-κB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-α and IL-1β.
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c260 cso30:c:InputProcess connector
c262 cso30:c:InputAssociation connector
c261 cso30:c:OutputProcess connector
p96_propro_p96
PMID: 18054516
STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-κB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-α and IL-1β.
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c263 cso30:c:InputProcess connector
c265 cso30:c:InputAssociation connector
c264 cso30:c:OutputProcess connector
p97_propro_p97
PMID: 18054516
STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-κB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-α and IL-1β.
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c266 cso30:c:InputProcess connector
c268 cso30:c:InputAssociation connector
c267 cso30:c:OutputProcess connector
p98_propro_p98
PMID: 18054516
STAT-4 expression can be induced in human primary DC by multiple stimuli activating NF-κB transcription factors, such as the ligands for TLR4, TLR2 and TLR3, various pathogens, CD40L and the pro-inflammatory cytokines TNF-α and IL-1β.
PMID: 18054516
Thus, under inflammatory conditions, NF-κB is activated and, in turn, induces STAT-4 whose activation by type I IFNs may regulate the transcription of specific target genes in mature DC.
c269 cso30:c:InputProcess connector
c271 cso30:c:InputAssociation connector
c270 cso30:c:OutputProcess connector
LPS_enti_MO000016882
LPS
TLR4:MD2_enti_e5
TLR4:MD2
LPS:TLR4:MD2_enti_e6
LPS:TLR4:MD2
TLR2_enti_MO000019397
TLR2
peptidoglycan:TLR2_enti_e11
peptidoglycan:TLR2
peptidoglycan_enti_e12
peptidoglycan
lipopolypeptides_enti_e13
lipopolypeptides
lipopolypeptides:TLR2_enti_e14
lipopolypeptides:TLR2
TLR5_enti_MO000019399
TLR5
flagellin:TLR5_enti_e18
flagellin:TLR5
flagellin_enti_MO000022185
flagellin
TLR7_enti_MO000042126
TLR7
ssRNA:TLR7_enti_e19
ssRNA:TLR7
ssRNA_enti_e20
ssRNA
TLR8_enti_MO000042007
TLR8
ssRNA:TLR8_enti_e21
ssRNA:TLR8
TLR3_enti_MO000019398
TLR3
dsRNA:TLR3_enti_MO000041446
dsRNA:TLR3
dsRNA_enti_MO000022224
dsRNA
TLR9_enti_MO000042012
TLR9
CpG DNA_enti_e22
CpG DNA
CpG DNA:TLR9_enti_e23
CpG DNA:TLR9
TRIF_enti_MO000041125
TRIF
dsRNA:TLR3:TRIF_enti_MO000041437
dsRNA:TLR3:TRIF
TRAM_enti_MO000041132
TRAM
LPS:TLR4:MD2:TRAM_enti_e24
LPS:TLR4:MD2:TRAM
LPS:TLR4:MD2:TRAM:TRIF_enti_e25
LPS:TLR4:MD2:TRAM:TRIF
imiquimod_enti_e26
imiquimod
imiquimod:TLR7_enti_e27
imiquimod:TLR7
R-848_enti_e28
R-848
R-848:TLR8_enti_e29
R-848:TLR8
R-848:TLR7_enti_e30
R-848:TLR7
MyD88_enti_MO000016573
MyD88
LPS:TLR4:MD2:MYD88_enti_e31
LPS:TLR4:MD2:MYD88
flagellin:TLR5:MYD88_enti_e32
flagellin:TLR5:MYD88
peptidoglycan:TLR2:MYD88_enti_e33
peptidoglycan:TLR2:MYD88
ssRNA:TLR7:MYD88_enti_e34
ssRNA:TLR7:MYD88
ssRNA:TLR8:MYD88_enti_e35
ssRNA:TLR8:MYD88
CpG DNA:TLR9:MYD88_enti_e36
CpG DNA:TLR9:MYD88
IKK-i:TBK1_enti_e37
IKK-i:TBK1
IKK-i:TBK1{active}_enti_e38
IKK-i:TBK1{active}
IRF-3_enti_MO000007694
IRF-3
IRF-3{p}_enti_MO000041456
IRF-3{p}
IRF-7{p}_enti_MO000041457
IRF-7{p}
IRF-7_enti_MO000007702
IRF-7
IRF-3{p}_enti_e39
IRF-3{p}
IRF-7{p}_enti_e40
IRF-7{p}
NF-kappaB_enti_MO000000058
NF-kappaB
ATF-2:c-Jun_enti_MO000055971
ATF-2:c-Jun
enhanceosome complex_enti_e41
enhanceosome complex
IFN-beta_enti_e42
IFN-beta
NF-kappaB{active}_enti_e43
NF-kappaB{active}
IFN-alpha_enti_e44
IFN-alpha
IFN-beta_enti_e47
IFN-beta
ISGF3_enti_e45
ISGF3
ISGF3{active}_enti_e46
ISGF3{active}
IRF7_enti_e48
IRF7
Pin1_enti_MO000017197
Pin1
IRF-3{p}:pin1_enti_e49
IRF-3{p}:pin1
IRF-3{p}{ub}:pin1_enti_e63
IRF-3{p}{ub}:pin1
protein remnants_enti_MO000019479
protein remnants
SARM_enti_e64
SARM
SIKE_enti_e65
SIKE
IKK-i:SIKE:TBK1_enti_e66
IKK-i:SIKE:TBK1
JAK_enti_e67
JAK
JAK{active}_enti_e68
JAK{active}
STAT1_enti_MO000013119
STAT1
STAT1{p}_enti_MO000019704
STAT1{p}
(stat1{p})2_enti_e69
(stat1{p})2
(stat1{p})2_enti_e70
(stat1{p})2
(stat1{p})2:IRF1SBE DNA_enti_e71
(stat1{p})2:IRF1SBE DNA
IRF1SBE_enti_e72
IRF1SBE
IRF7 ISRE:ISGF3{act}_enti_e73
IRF7 ISRE:ISGF3{act}
IRF7 ISRE_enti_e74
IRF7 ISRE
IRF1_enti_e75
IRF1
IFN-alpha1_enti_e76
IFN-alpha1
IFN-alpha1_enti_e77
IFN-alpha1
DDX58_enti_MO000066987
DDX58
dsRNA:DDX58_enti_e78
dsRNA:DDX58
IFIH1_enti_MO000103999
IFIH1
dsRNA:IFIH1_enti_e79
dsRNA:IFIH1
dsRNA:DDX58:MAVS_enti_e80
dsRNA:DDX58:MAVS
MAVS_enti_MO000094908
MAVS
IKK_enti_MO000000248
IKK
dsRNA:DDX58:MAVS:IKK_enti_e81
dsRNA:DDX58:MAVS:IKK
NF-kappaB_enti_e82
NF-kappaB
IRF_enti_e83
IRF
IRF{active}_enti_e84
IRF{active}
DAI_enti_e85
DAI
DNA:DAI_enti_e86
DNA:DAI
HLA-DR_enti_e87
HLA-DR
HLA-DR_enti_e88
HLA-DR
CD54_enti_e89
CD54
CD54_enti_e90
CD54
CD80_enti_e91
CD80
CD80_enti_e92
CD80
CD86_enti_e93
CD86
CD86_enti_e94
CD86
CXCL9_enti_e95
CXCL9
CXCL9_enti_e96
CXCL9
CXCL10_enti_e97
CXCL10
CXCL11_enti_e98
CXCL11
CXCL10_enti_e99
CXCL10
CXCL11_enti_e100
CXCL11
IL-12_enti_e101
IL-12
IL-12_enti_e102
IL-12
CD40_enti_e103
CD40
Stat1_enti_e104
Stat1
STAT2_enti_MO000013120
STAT2
STAT2_enti_G011682
STAT2
STAT4_enti_MO000017181
STAT4
STAT4_enti_G011698
STAT4
STAT4_enti_e105
STAT4
target genes_enti_e106
target genes
TNF-alpha_enti_MO000000289
TNF-alpha
IL-1beta_enti_e107
IL-1beta
CD40L_enti_e108
CD40L