1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18064347.csml convertedTime:2009.07.01.11:11

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors are key participants in innate immune responses.
Authors Arancibia SA, Beltran CJ, Aguirre IM, Silva P, Peralta AL, Malinarich F, HermosoMA.
Affiliation Programa Disciplinario de Inmunologia, Instituto de Ciencias Biomedicas,Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Abstract During an infection, one of the principal challenges for the host is to detectthe pathogen and activate a rapid defensive response. The Toll-like family ofreceptors (TLRs), among other pattern recognition receptors (PRR), performs thisdetection process in vertebrate and invertebrate organisms. These type Itransmembrane receptors identify microbial conserved structures orpathogen-associated molecular patterns (PAMPs). Recognition of microbialcomponents by TLRs initiates signaling transduction pathways that induce geneexpression. These gene products regulate innate immune responses and furtherdevelop an antigen-specific acquired immunity. TLR signaling pathways areregulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, betweenothers that provide specificity of individual TLR- mediated signaling pathways.TLR-mediated activation of innate immunity is involved not only in host defenseagainst pathogens but also in immune disorders. The involvement of TLR-mediatedpathways in auto-immune and inflammatory diseases is described in this reviewarticle.
PMID 18064347
Model Abstract

Entity

G010228:IFN-beta G010329:TNF-alpha G010693:Tlr4 G014880:TRAM MO000000030:PI3K MO000000048:AKT MO000000058:NF-kappaB MO000000212:TRAF6 MO000000248:IKK MO000000289:TNF-alpha MO000000331:PIP2 MO000007694:IRF-3 MO000007702:IRF-7 MO000016566:IRAK-2 MO000016569:IRAK-M MO000016573:MyD88 MO000016882:LPS MO000017272:PIP3 MO000017426:fibrinogen MO000017549:fibronectin MO000018132:CD14 MO000019394:TLR4 MO000019396:TLR1 MO000019397:TLR2 MO000019398:TLR3 MO000019399:TLR5 MO000019406:Tollip MO000019420:LBP MO000019422:TLR6 MO000020119:Hsp60 MO000020461:Nod2 MO000021614:Hsp70 MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022131:MD-2 MO000022136:Ubc13 MO000022185:flagellin MO000022224:dsRNA MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000044794:ST2L MO000066718:SIGIRR e1: e10: e100:MKK e101:MKK{p} e102:LPS:TLR4:MD2:TRAM e103:LPS:TLR4:MYD88:IRAK4{p} e104:MYD88s e105:diacylated lipopeptide:TLR2:TLR6:PI3K e106:LPS:TLR4:MD2:Tollip e107:MDP e108:MDP:Nod2 e109:ST2L:MYD88 e11:diacylated lipopeptide e110:ST2s e111:LPS:TLR4:MD2:SIGIRR e112:IL-1R e113:IL-1:IL-1R e114:IL-1 e115:IL-1:IL-1R:SIGIRR e116:MAL e117:ST2L:MAL e12:diacylated lipoprotein:TLR2:TLR6 e13:triacylated lipopeptide e14:triacylated lipopeptide:TLR1:TLR2 e15:taxol e16:taxol:TLR4 e17:viral fusion protein e18:viral fusion protein:TLR4 e19:hsp60:TLR4 e2: e20:hsp70:TLR4 e21:fibronectin:TLR4 e22:flagellin:TLR5 e23:hyaluronic acid:TLR4 e24:hyaluronic acid e25:fibrinogen:TLR4 e26:heparan sulfate:TLR4 e27:heparan sulfate e28:TLR4:CD14 e29:LPS:TLR4:MD2 e3: e30:CpG DNA e31:CpG DNA:TLR9 e32:ssRNA:TLR7 e33:type I interferons e34:type I interferon e35: e36: e37: e38:IRF-3{active} e39:IRF-7{active} e4: e40:cytokine e41:cytokine e42:LPS:TLR4:MD2:MYD88 e43:diacylated lipopeptide:TLR2:TLR6:MYD88 e44:flagellin:TLR5:MYD88 e45:CpG DNA:TLR9:MYD88 e46:ssRNA:TLR8:MYD88 e47:ssRNA:TLR7:MYD88 e48:IRAK1 e49:LPS:TLR4:MD2:MYD88:IRAK4 e5:TLR1:TLR2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR2:TLR6 e60: e61: e62: e63:diacylated lipopeptide:TLR2:TLR6:MYD88:IRAK1:TRAF6 e64:flagellin:TLR5:MYD88:IRAK1:TRAF6 e65:IKK{active} e66:Ikappa-B alpha:NF-kappaB e67:Ikappa-B alpha{p}:NF-kappaB e68:protein remnants e69:NF-kappaB e7: e70:adhesion molecule e71:LPS:TLR4:MD2:TRIF:PI3K e72:diacylated lipopeptide:TLR2:TLR6:TRIF:PI3K e73:dsRNA:TLR3:TRIF e74:TBK1:IKK-epsilon e75:TBK1:IKK-epsilon {active} e76:IRF e77:IRF{active} e78:PI3K{active} e79:IFN-alpha e8:ssRNA e80:IFN-alpha e81:IFN-beta e82:TLR4:CD14:MD2 e83:sTLR4 e84:NF-kappaB{active} e85:dsRNA:TLR3{p} e86:dsRNA:TLR3:PI3K e87:AKT{active} e88:LPS:TLR4:MD2:MYD88:IRAK4{p}:IRAK1 e89:LPS:TLR4:MD2:MYD88:IRAK4{p}:IRAK1{p} e9:ssRNA:TLR8 e90:LPS:TLR4:MD2:MYD88:IRAK4:IRAK1{p}:TRAF6 e91:IRAK1{p}:TRAF6 e92:TAK1:TAB1:TAB2 e93:IRAK1{p}:TRAF6:TAK1:TAB1:TAB2 e94:IRAK1{p}:TRAF6:TAK1:TAB1{p}:TAB2{p} e95:TRAF6:TAK1:TAB1{p}:TAB2{p} e96:IRAK1{p} e97:UevlA e98:TRAF6:UVEIa:Ubc13:TAK1:TAB1{p}:TAB2{p} e99:IKK{p}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90
Model Detail
954.0, 1438.0
36.0, 36.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p56 p78

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
1295.0, 1346.5
34.5, 34.5

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
1026.0, 1596.0
34.0, 34.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p88

--

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
1250.0, 1526.0
32.0, 32.0

TRAM

--

G014880

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p75

p76

true true true true

csml-variable:Double

m96947

10

false

infinite

0

unit false false false
TRANSFACG014880

--

Go back
1627.0, 323.0
42.0, 42.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p47 p53

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
576.0, 1048.0
32.0, 32.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1382.0, 1042.0
28.0, 28.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p58 p81

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1480.0, 376.0
32.0, 32.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p37 p65

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1361.0, 501.0
38.0, 38.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p41 p70

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1868.0, 1359.5
32.5, 32.5

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1078.0, 362.0
36.0, 36.0

PIP2

--

MO000000331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80

true true true true

csml-variable:Double

m290229

10

false

infinite

0

unit false false false
TRANSPATHMO000000331

--

Go back
989.0, 357.0
22.0, 22.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p23 p48 p63

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
999.0, 743.0
34.0, 34.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p25

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1449.0, 861.0
38.0, 38.0

IRAK-2

--

MO000016566

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p65

true true true true

csml-variable:Double

m1569

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
1533.0, 1565.0
38.0, 38.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p65

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
1555.0, 255.0
26.0, 26.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30 p31 p32 p33 p34 p85

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1964.0, 80.0
31.0, 31.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1187.0, 483.0
34.0, 34.0

PIP3

--

MO000017272

cso30:c:Protein

cso30:i:CC_CellComponent

--

p80

--

true true true true

csml-variable:Double

m157492

10

false

infinite

0

unit false false false
TRANSPATHMO000017272

--

Go back
2049.0, 710.0
32.0, 32.0

fibrinogen

--

MO000017426

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m2254

10

false

infinite

0

unit false false false
TRANSPATHMO000017426

--

Go back
2009.0, 542.0
32.0, 32.0

fibronectin

--

MO000017549

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m2341

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017549

--

Go back
1634.0, 150.0
36.0, 36.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p57

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
1718.0, 298.0
36.0, 36.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p11 p8 p6 p12 p9 p7 p10 p57

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
963.0, 176.0
32.0, 32.0

TLR1

--

MO000019396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3963

10

false

infinite

0

unit false false false
InterProIPR003016
TRANSPATHMO000019396

--

Go back
1026.0, 175.0
34.0, 34.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
826.0, 826.0
27.0, 27.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
747.0, 171.0
34.0, 34.0

TLR5

--

MO000019399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m3966

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019399

--

Go back
605.0, 321.0
30.0, 30.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

p82

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
1882.0, 42.0
28.0, 28.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p13

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
1077.0, 174.0
36.0, 36.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
1986.0, 427.0
30.0, 30.0

Hsp60

--

MO000020119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m4645

10

false

infinite

0

unit false false false
InterProIPR002423
TRANSPATHMO000020119

--

Go back
555.0, 463.0
34.0, 34.0

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
1979.0, 492.0
28.0, 28.0

Hsp70

--

MO000021614

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m5956

10

false

infinite

0

unit false false false
InterProIPR001023
TRANSPATHMO000021614

--

Go back
1737.0, 69.0
30.0, 30.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p14

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
1712.0, 156.0
32.0, 32.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p16

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
1777.0, 221.0
38.0, 38.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1572.0, 1268.0
32.0, 32.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
641.0, 69.0
30.0, 30.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
902.0, 830.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1357.0, 257.0
30.0, 30.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1451.0, 439.0
34.0, 34.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46 p47 p50

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1384.0, 440.0
32.0, 32.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

p74

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
804.0, 876.0
24.0, 24.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p50 p53 p60

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1066.0, 694.0
28.0, 28.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63

--

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
641.0, 661.0
29.0, 29.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
788.0, 644.0
31.0, 31.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
696.0, 608.0
31.0, 31.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
470.0, 466.0
44.0, 44.0

ST2L

--

MO000044794

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85 p90

true true true true

csml-variable:Double

m22464

10

false

infinite

0

unit false false false
TRANSPATHMO000044794

--

Go back
469.0, 737.0
38.0, 38.0

SIGIRR

--

MO000066718

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87 p89

true true true true

csml-variable:Double

m41575

10

false

infinite

0

unit false false false
TRANSPATHMO000066718

--

Go back
439.80357055920206, 136.51462201938716
1343.8462115832956, 1951.2646992189452

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
463.8546703208824, 212.54354783241178
1312.213130280019, 1845.9149002192783

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1215.0, 913.0327027570938
34.81183336687463, 21.467297242906017

MKK

--

e100

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p72

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
1251.0, 1025.0327027570938
34.81183336687463, 21.467297242906017

MKK{p}

--

e101

cso30:c:Protein

cso30:i:CC_Extracellular

--

p72

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1550.0, 164.94117647058823
28.23529411764707, 47.05882352941177

LPS:TLR4:MD2:TRAM

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p46

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1479.0, 165.73529411764702
26.558823529411768, 44.26470588235295

LPS:TLR4:MYD88:IRAK4{p}

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p79

p38

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
808.0, 412.01964452759586
16.891487371375113, 38.98035547240411

MYD88s

--

e104

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p58 p64 p79

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
473.0, 326.38235294117646
30.97058823529412, 51.617647058823536

diacylated lipopeptide:TLR2:TLR6:PI3K

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p77

p81

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
466.5, 211.02018719031025
35.81886584694439, 49.979812809689854

LPS:TLR4:MD2:Tollip

--

e106

cso30:c:Complex

cso30:i:CC_Extracellular

--

p82

p64 p83

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
598.0, 417.5895710681245
51.90075693860387, 29.410428931875526

MDP

--

e107

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p84

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
729.0, 402.91160220994476
30.679558011049725, 34.088397790055254

MDP:Nod2

--

e108

cso30:c:Complex

cso30:i:CC_Extracellular

--

p84

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
475.0, 553.3204419889503
33.91160220994475, 37.67955801104973

ST2L:MYD88

--

e109

cso30:c:Complex

cso30:i:CC_Extracellular

--

p85

p58

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
1237.0, 28.241652021089635
35.782073813708266, 23.25834797891037

diacylated lipopeptide

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
733.5, 2140.3119339907425
30.640974039042064, 49.688066009257405

ST2s

--

e110

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p88

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
468.0, 805.029411764706
32.38235294117647, 53.97058823529412

LPS:TLR4:MD2:SIGIRR

--

e111

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p87

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
476.5, 912.4745166959578
32.19156414762742, 49.525483304042176

IL-1R

--

e112

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p86

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
476.5, 1014.0
31.0, 60.0

IL-1:IL-1R

--

e113

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p86

p89

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
322.0, 1012.0149384885764
42.28471001757469, 27.48506151142355

IL-1

--

e114

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p86

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
472.5, 1138.1424114516426
31.431271792989545, 43.857588548357505

IL-1:IL-1R:SIGIRR

--

e115

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p89

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
585.0, 569.5098611390622
45.38941436908835, 27.990138860937815

MAL

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p90

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
470.5, 638.7672054657558
35.30678220296617, 43.23279453424429

ST2L:MAL

--

e117

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p90

p58

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
1189.5, 168.1614975224811
28.55092677555515, 39.838502477518816

diacylated lipoprotein:TLR2:TLR6

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p30 p47 p77

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
773.0, 54.59841827768017
44.463971880492096, 28.901581722319865

triacylated lipopeptide

--

e13

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
853.5, 172.05340429436603
27.911726922371088, 38.94659570563406

triacylated lipopeptide:TLR1:TLR2

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
2033.0, 300.54835996635825
48.444070647603034, 27.451640033641716

taxol

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1729.5, 356.86472264854194
22.28655996491997, 43.135277351458015

taxol:TLR4

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1941.0, 361.50321996377545
40.535318977661504, 24.996780036224592

viral fusion protein

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1729.5, 414.77329532997146
23.88379741284806, 46.226704670028504

viral fusion protein:TLR4

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1733.5, 479.180881385661
23.156544617408464, 44.81911861433897

hsp60:TLR4

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
439.80357055920206, 136.51462201938716
1343.8462115832956, 1951.2646992189452

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1728.5, 542.4051743038806
24.590659942994954, 47.59482569611927

hsp70:TLR4

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1729.5, 606.8522253891691
23.84301688226266, 46.147774610830965

fibronectin:TLR4

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
679.5, 163.90550317912738
25.36549002411752, 49.09449682087261

flagellin:TLR5

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p31

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
1724.5, 661.8002631001973
25.419864064898047, 49.19973689980268

hyaluronic acid:TLR4

--

e23

cso30:c:Complex

cso30:i:CC_Extracellular

--

p10

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
1978.0, 646.5315391084945
53.76787216148024, 30.46846089150547

hyaluronic acid

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1724.5, 728.8531023898269
25.909230431922825, 50.146897610173205

fibrinogen:TLR4

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1725.5, 795.7070817803113
22.88467441350581, 44.292918219688666

heparan sulfate:TLR4

--

e26

cso30:c:Complex

cso30:i:CC_Extracellular

--

p12

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1983.0, 783.5037846930193
52.05214465937763, 29.49621530698066

heparan sulfate

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1715.5, 199.7767038826862
32.84902516247292, 40.22329611731379

TLR4:CD14

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p14 p15

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1593.5, 163.24554964213615
29.924022756469075, 41.754450357863824

LPS:TLR4:MD2

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16 p83

p29 p58 p59 p74 p75 p76 p82 p88 p87

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
471.8185938324986, 164.6760710114608
1290.092363119963, 1897.5108507556138

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
894.0, 657.5
60.0, 13.0

CpG DNA

--

e30

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p18

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
816.5, 689.207410655558
23.65950449462837, 45.79258934444201

CpG DNA:TLR9

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p32

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
745.5, 607.9432142074105
21.2126726595045, 41.05678579258935

ssRNA:TLR7

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20 p22 p24 p34

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1154.0, 1292.1384083044984
44.740484429065745, 23.86159169550173

type I interferons

--

e33

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p20 p49

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
682.0, 1276.975678203929
19.94387277829747, 46.024321796071085

type I interferon

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20 p49

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
656.0, 618.0
199.0043047048335, 332.23600022756125

--

e35

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false true false

--

Go back
656.0, 618.0
199.0043047048335, 332.23600022756125

--

e36

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false true false

--

Go back
656.0, 618.0
199.0043047048335, 332.23600022756125

--

e37

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false true false

--

Go back
965.0, 609.0
22.0, 22.0

IRF-3{active}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22 p23 p48

p27 p49 p78

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
998.0, 870.0
27.0, 27.0

IRF-7{active}

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p25

p26

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
516.4028046194499, 210.4261636564682
1190.647743462801, 1803.4416159447824

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1238.0, 1425.8685121107267
48.99653979238754, 26.13148788927336

cytokine

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44

p26 p27

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1597.0, 1434.0600000000002
37.919999999999995, 28.439999999999998

cytokine

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p26 p27

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1515.0, 165.73529411764707
26.558823529411768, 44.26470588235294

LPS:TLR4:MD2:MYD88

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p35

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1258.0, 164.82352941176472
27.705882352941174, 46.17647058823529

diacylated lipopeptide:TLR2:TLR6:MYD88

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p36

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
613.5, 163.3797026977427
29.11121306661773, 40.6202973022573

flagellin:TLR5:MYD88

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p37

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
834.5, 729.5729491649845
26.822719765094515, 37.427050835015606

CpG DNA:TLR9:MYD88

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
655.5, 762.3147366489266
24.85777206826941, 34.685263351073594

ssRNA:TLR8:MYD88

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
664.5, 616.4309047531658
22.624518260231238, 31.56909524683428

ssRNA:TLR7:MYD88

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1085.0, 247.5010062386799
38.91728718051922, 23.99899376132018

IRAK1

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36 p37 p38

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1435.0, 157.73529411764702
26.558823529411768, 44.26470588235294

LPS:TLR4:MD2:MYD88:IRAK4

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35 p66

p79

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
913.5, 175.0054990834861
26.945509081819697, 32.99450091651392

TLR1:TLR2

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p4

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
867.2556376463865, 1178.4060121798325
568.9333558989405, 515.9600452938255

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
928.7046779483205, 1190.6335151653739
332.67239060012537, 500.0680521122907

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
874.6719011311026, 1185.2925425584972
554.1008289295086, 502.18698453649534

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
875.7313673432049, 1186.3520087705995
551.9818965053032, 500.0680521122907

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
867.2556376463865, 1178.4060121798325
568.9333558989405, 515.9600452938255

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
867.2556376463865, 1178.4060121798325
568.9333558989405, 515.9600452938255

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
875.7313673432049, 1186.3520087705995
551.9818965053032, 500.0680521122907

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1282.5663927904923, 1390.2992546002945
35.543830069924056, 32.17651985277339

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
1189.3333661254896, 1538.6245242946165
100.64929014971938, 91.11409424079876

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
867.2556376463865, 1178.4060121798325
568.9333558989405, 515.9600452938255

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1128.5, 173.34610898183632
29.93401099816697, 36.65389101816363

TLR2:TLR6

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
1001.3500284641143, 1407.6943928954563
18.017283421565388, 8.674988314087054

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
1000.7483803712776, 1381.823524903476
61.66892951576651, 111.00407312837966

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
1026.619248363258, 1454.0212960438864
9.626369485387928, 9.626369485387935

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1305.0, 163.29411764705884
29.823529411764707, 49.70588235294118

diacylated lipopeptide:TLR2:TLR6:MYD88:IRAK1:TRAF6

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p40

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
557.0, 162.8529411764706
30.08823529411765, 50.14705882352941

flagellin:TLR5:MYD88:IRAK1:TRAF6

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1301.0, 693.0
38.0, 38.0

IKK{active}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40 p41

p39

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
1207.0, 809.7127071823205
25.45856353591161, 28.28729281767956

Ikappa-B alpha:NF-kappaB

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p39 p73

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1383.0, 809.0552486187845
26.950276243093928, 29.944751381215465

Ikappa-B alpha{p}:NF-kappaB

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39 p73

p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1446.0, 978.4991384261918
28.449167145318782, 27.50086157380815

protein remnants

--

e68

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1270.0, 1306.0
28.0, 28.0

NF-kappaB

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

p44 p45

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
434.54887127495806, 225.48120243596645
1025.9782455608404, 1453.7846726766147

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1109.0, 1545.3771626297578
53.667820069204154, 28.622837370242216

adhesion molecule

--

e70

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1394.0, 165.70588235294116
27.176470588235297, 45.294117647058826

LPS:TLR4:MD2:TRIF:PI3K

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p48

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1347.0, 162.9411764705883
25.23529411764706, 42.05882352941177

diacylated lipopeptide:TLR2:TLR6:TRIF:PI3K

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
753.5, 911.3466691135989
29.13488713525418, 40.65333088640118

dsRNA:TLR3:TRIF

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p51

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
999.0, 1007.7071823204418
24.5635359116022, 27.292817679558013

TBK1:IKK-epsilon

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p51

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1065.0, 1067.5856353591162
22.872928176795586, 25.41436464088398

TBK1:IKK-epsilon {active}

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p52

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
956.5, 1121.570134835983
22.465083517810427, 36.4298651640169

IRF

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52 p54

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1135.5, 1076.5634936606964
24.31917890923727, 39.43650633930368

IRF{active}

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p52 p54

p55 p56

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1511.0, 643.0
42.0, 42.0

PI3K{active}

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p54 p58 p59 p61 p72 p80 p77

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1061.0, 1367.6678200692043
45.622837370242216, 24.33217993079585

IFN-alpha

--

e79

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p55

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
717.0, 516.3035518526639
46.831835123876346, 24.19644814733611

ssRNA

--

e8

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p19 p21

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
589.0, 1366.4199999999998
37.440000000000005, 28.080000000000005

IFN-alpha

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p55

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
597.0, 1438.5826010544813
29.103690685413, 18.917398945518453

IFN-beta

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p56 p78

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1720.5, 259.2196733345569
23.49256744356763, 32.780326665443205

TLR4:CD14:MD2

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
2108.0, 214.7513181019332
39.61335676625659, 25.748681898066785

sTLR4

--

e83

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1502.0, 1150.0
28.0, 28.0

NF-kappaB{active}

--

e84

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58 p81

p43

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
712.0, 936.0
24.0, 24.0

dsRNA:TLR3{p}

--

e85

cso30:c:Protein

cso30:i:CC_CellComponent

--

p60

p61

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
663.5, 914.7882180216557
24.518443751147004, 34.21178197834466

dsRNA:TLR3:PI3K

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

p62

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
680.0, 1156.0
32.0, 32.0

AKT{active}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p62

p63

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
1723.0, 850.7647058823529
25.941176470588232, 43.23529411764706

LPS:TLR4:MD2:MYD88:IRAK4{p}:IRAK1

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p64

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
1719.0, 906.029411764706
26.382352941176475, 43.97058823529412

LPS:TLR4:MD2:MYD88:IRAK4{p}:IRAK1{p}

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65 p83

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
653.5, 711.3380837535627
21.52532339399254, 41.66191624643719

ssRNA:TLR8

--

e9

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p23 p25 p33

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
1722.0, 968.529411764706
27.88235294117647, 46.47058823529412

LPS:TLR4:MD2:MYD88:IRAK4:IRAK1{p}:TRAF6

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p66

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1652.0, 1009.8121546961324
32.569060773480665, 36.187845303867405

IRAK1{p}:TRAF6

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

p67

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1644.5, 1063.4288860341348
23.342631675536797, 32.57111396586531

TAK1:TAB1:TAB2

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p67

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1658.0, 1107.9117647058822
28.85294117647059, 48.08823529411765

IRAK1{p}:TRAF6:TAK1:TAB1:TAB2

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p68

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1655.0, 1158.5
25.5, 42.5

IRAK1{p}:TRAF6:TAK1:TAB1{p}:TAB2{p}

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p68

p69

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
1643.0, 1225.735294117647
26.558823529411764, 44.26470588235295

TRAF6:TAK1:TAB1{p}:TAB2{p}

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

p71

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1578.0, 1177.4146341463415
35.731707317073166, 28.585365853658534

IRAK1{p}

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p69

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1519.0, 1233.7549808814651
33.64057154357013, 20.745019118534913

UevlA

--

e97

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p71

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1723.0, 1302.7941176470588
25.323529411764703, 42.20588235294118

TRAF6:UVEIa:Ubc13:TAK1:TAB1{p}:TAB2{p}

--

e98

cso30:c:Complex

cso30:i:CC_Extracellular

--

p71

p70 p72

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1389.0, 741.2439024390244
37.19512195121951, 29.756097560975604

IKK{p}

--

e99

cso30:c:Protein

cso30:i:CC_Cytosol

--

p70

p73

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
968.0, 105.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019396 MO000019397

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3963*m3964*0.1

nodelay

--

true

0

false

PMID: 18064347, 11431423, 12077222 the association between TLR1 and TLR6 which were demonstrated to form heterodimeric complexes with TLR2.

Go back
1879.0, 652.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000019394

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m24*m3961*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 is activated by endogenous ligands, such as heat shock protein 60 (HSP60), HSP70, fibronectin, hyaluronic acid, fibrinogen and heparan sulfate.

Go back
1855.0, 716.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000017426

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c31 : 1

m3961*m2254*0.1

nodelay

--

true

0

false

Go back
1846.0, 788.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e27

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m3961*m27*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 is activated by endogenous ligands, such as heat shock protein 60 (HSP60), HSP70, fibronectin, hyaluronic acid, fibrinogen and heparan sulfate.

Go back
1885.0, 129.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019420 MO000016882

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m3985*m155666*0.1

nodelay

--

true

0

false

PMID: 18064347, 11274165 LPS is generally bound to LPS-binding protein (LBP) present in the serum, this complex is firstly recognized by CD14 receptor, strongly expressed in peripheral blood monocytes and macrophages.

Go back
1641.0, 73.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021928 e28

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m6254*m28*0.1

nodelay

--

true

0

false

PMID: 18064347, 11274165 LPS is generally bound to LPS-binding protein (LBP) present in the serum, this complex is firstly recognized by CD14 receptor, strongly expressed in peripheral blood monocytes and macrophages.

Go back
1868.0, 208.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022131 e28 e83

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c43 : 1
stoichiometry:c176 : 1
stoichiometry:c45 : 1

m6438*m28*0.1

nodelay

--

true

0

false

PMID: 18064347, 11274165 Once bound to CD14, LPS comes in close proximity with TLR4; however the efficient triggering of an inflammatory response requires the expression of the secreted protein MD-2

Go back
1808.0, 196.0
23.0, 23.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021929 e82

e29 MO000019420 MO000018132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m6255*m84*0.1

nodelay

--

true

0

false

PMID: 18064347, 11274165 Once bound to CD14, LPS comes in close proximity with TLR4; however the efficient triggering of an inflammatory response requires the expression of the secreted protein MD-2

Go back
716.0, 92.0
23.0, 23.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022185 MO000019399

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m6485*m3966*0.1

nodelay

--

true

0

false

PMID: 18064347, 14625549 TLR5 recognizes a flagellin portion derived from Gram-positive and negative bacteria.

Go back
844.0, 652.0
23.0, 23.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000042012

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m30*m19828*0.1

nodelay

--

true

0

false

PMID: 18064347, 15345224, 14993594, 12900525, 14563635 TLR9 senses DNA from Murine Cytomegalovirus (MCMV) and Herpes Simplex virus 1 and 2.

Go back
730.0, 570.0
19.0, 19.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e8

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m19940*m8*0.1

nodelay

--

true

0

false

PMID: 18064347, 14976262, 15804288, 15661881 TLR7 responds to ssRNA producing interferon type I (IFN type I) and pro-inflammatory cytokines.

Go back
1064.0, 69.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019397 MO000019422

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m3964*m3987*0.1

nodelay

--

true

0

false

Go back
824.0, 1288.0
23.0, 23.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e33 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c60 : 1

m33*m32*0.1

nodelay

--

true

0

false

PMID: 18064347, 14976262, 15804288, 15661881 TLR7 responds to ssRNA producing interferon type I (IFN type I) and pro-inflammatory cytokines.

Go back
578.0, 666.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e8

e9

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m19823*m8*0.1

nodelay

--

true

0

false

PMID: 18064347, 15361868, 16006187 TLR7 and TLR8 recognize viral and non-viral ssRNA and activate cytokine production through interferon regulatory factor 3 (IRF3) and IRF7.

Go back
970.0, 529.5
20.5, 20.5

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e32

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m977*m32*0.1

nodelay

--

true

0

false

PMID: 18064347, 15361868, 16006187 TLR7 and TLR8 recognize viral and non-viral ssRNA and activate cytokine production through interferon regulatory factor 3 (IRF3) and IRF7.

Go back
918.0, 510.5
19.5, 19.5

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e9

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m977*m9*0.1

nodelay

--

true

0

false

PMID: 18064347, 15361868, 16006187 TLR7 and TLR8 recognize viral and non-viral ssRNA and activate cytokine production through interferon regulatory factor 3 (IRF3) and IRF7.

Go back
1029.0, 821.0
21.0, 21.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000007702

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m32*m980*0.1

nodelay

--

true

0

false

PMID: 18064347, 15361868, 16006187 TLR7 and TLR8 recognize viral and non-viral ssRNA and activate cytokine production through interferon regulatory factor 3 (IRF3) and IRF7.

Go back
929.0, 789.0
21.0, 21.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007702 e9

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m980*m9*0.1

nodelay

--

true

0

false

PMID: 18064347, 15361868, 16006187 TLR7 and TLR8 recognize viral and non-viral ssRNA and activate cytokine production through interferon regulatory factor 3 (IRF3) and IRF7.

Go back
1476.0, 1400.0
23.0, 23.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c82 : 1
stoichiometry:c79 : 1

m40*m39*0.1

nodelay

--

true

0

false

PMID: 18064347, 15361868, 16006187 TLR7 and TLR8 recognize viral and non-viral ssRNA and activate cytokine production through interferon regulatory factor 3 (IRF3) and IRF7.

Go back
1471.0, 1471.0
17.0, 17.0

p27

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e38

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c80 : 1

m40*m38*0.1

nodelay

--

true

0

false

PMID: 18064347, 15361868, 16006187 TLR7 and TLR8 recognize viral and non-viral ssRNA and activate cytokine production through interferon regulatory factor 3 (IRF3) and IRF7.

Go back
870.0, 878.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c85 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18064347, 16095970, 15829275, 15254159 Adequate host defense against viral infections involves rapid pathogen recognition by TLR3, TLR7, TLR8 and TLR9 among other PRRs. The viral PAMPs recognized by these receptors include: double-stranded RNA (dsRNA), single-stranded RNA (ssRNA) and double-stranded DNA (dsDNA)

Go back
1585.0, 57.0
21.0, 21.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 MO000016573

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m29*m1572*0.1

nodelay

--

true

0

false

PMID: 18064347 when TLR2,4 and 5 are activated MYD88 is recruited to TLR/TIR domain to induce pro inflammatory cytokine through a classical signal pathway.

Go back
1148.0, 73.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m6*m11*0.1

nodelay

--

true

0

false

PMID: 18064347, 11431423, 12077222 TLR6 association with TLR2 induced recognition of diacylated lipopeptide but TLR1-TLR2 heterodimer binds preferentially triacylated lipopeptides.

Go back
1280.0, 68.0
23.0, 23.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000016573

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m12*m1572*0.1

nodelay

--

true

0

false

PMID: 18064347 When TLR2,4 and 5 are activated MYD88 is recruited to TLR/TIR domain to induce pro inflammatory cytokine through a classical signal pathway.

Go back
888.0, 32.0
23.0, 23.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016573

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m22*m1572*0.1

nodelay

--

true

0

false

PMID: 18064347 When TLR2,4 and 5 are activated MYD88 is recruited to TLR/TIR domain to induce pro inflammatory cytokine through a classical signal pathway.

Go back
1165.0, 572.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000016573

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m31*m1572*0.1

nodelay

--

true

0

false

PMID: 18064347 During viral recognition in endosome TLR7, 8 and 9 use the cytoplasmic adaptor molecule MYD88.

Go back
582.0, 770.0
19.0, 19.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e9 MO000016573

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m9*m1572*0.1

nodelay

--

true

0

false

PMID: 18064347 During viral recognition in endosome TLR7, 8 and 9 use the cytoplasmic adaptor molecule MYD88.

Go back
648.0, 536.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 MO000016573

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c104 : 1
stoichiometry:c103 : 1

m32*m1572*0.1

nodelay

--

true

0

false

PMID: 18064347 During viral recognition in endosome TLR7, 8 and 9 use the cytoplasmic adaptor molecule MYD88.

Go back
1393.0, 65.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000039077

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c108 : 1

m42*m17258*0.1

nodelay

--

true

0

false

PMID: 18064347 A crucial event in pro-inflammatory signaling activation is the interaction of IRAK-4 with MyD88-ID domain that promotes, after recruitment to the receptor TIR domain, the phosphorylation of IRAK-1.

Go back
1206.0, 294.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000000212 e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c112 : 1

m43*m183*m48*0.1

nodelay

--

true

0

false

PMID: 18064347 When TLR2, 4 and 5 are activated, MyD88 is recruited to the TLR/TIR domain to induce pro-inflammatory cytokine production through a classical signaling pathway. In this pathway the IKK family of proteins is activated in a process that involves IRAK-1 and TRAF6.

Go back
712.0, 276.0
23.0, 23.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e44 e48 MO000000212

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m44*m48*m183*0.1

nodelay

--

true

0

false

PMID: 18064347 When TLR2, 4 and 5 are activated, MyD88 is recruited to the TLR/TIR domain to induce pro-inflammatory cytokine production through a classical signaling pathway. In this pathway the IKK family of proteins is activated in a process that involves IRAK-1 and TRAF6.

Go back
1600.0, 684.0
23.0, 23.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e103 MO000016569 MO000016566

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c237 : 1
stoichiometry:c241 : 1
stoichiometry:c243 : 1
stoichiometry:c118 : 1

m48*m106*0.1

nodelay

--

true

0

false

PMID: 18064347 A crucial event in pro-inflammatory signaling activation is the interaction of IRAK-4 with MyD88-ID domain that promotes, after recruitment to the receptor TIR domain, the phosphorylation of IRAK-1. PMID: 18064347, 12150927 IRAK-M and IRAK-2 block pro-inflammatory cytokine expression by dissociating the complex formed by MyD88-IRAK-l/-4 and IRAK-TRAF6. IRAK-M -/- mice show an over-production of inflammatory cytokines in response to LPS and bacterial DNA-like CpG motifs.

Go back
1319.0, 815.0
17.0, 17.0

p39

p39

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e66 e65

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m66*m65*0.1

nodelay

--

true

0

false

PMID: 18064347 The IKK complex catalyzes I¦ÊB¦Á phosphorylation and degradation by the proteasome, therefore allowing NF¦ÊB to translocate into the nucleus.

Go back
880.0, 97.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m5*m13*0.1

nodelay

--

true

0

false

PMID: 18064347, 11431423, 12077222 TLR6 association with TLR2 induced recognition of diacylated lipopeptide but TLR1-TLR2 heterodimer binds preferentially triacylated lipopeptides.

Go back
1335.0, 611.0
17.0, 17.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e63

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c124 : 1

m207*m63*0.1

nodelay

--

true

0

false

PMID: 18064347 When TLR2, 4 and 5 are activated, MyD88 is recruited to the TLR/TIR domain to induce pro-inflammatory cytokine production through a classical signaling pathway. In this pathway the IKK family of proteins is activated in a process that involves IRAK-1 and TRAF6.

Go back
1278.0, 594.0
19.0, 19.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000248 e64

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m207*m64*0.1

nodelay

--

true

0

false

PMID: 18064347 When TLR2, 4 and 5 are activated, MyD88 is recruited to the TLR/TIR domain to induce pro-inflammatory cytokine production through a classical signaling pathway. In this pathway the IKK family of proteins is activated in a process that involves IRAK-1 and TRAF6.

Go back
1385.0, 909.0
21.0, 21.0

p42

p42

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e67

e68 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18064347 The IKK complex catalyzes I¦ÊB¦Á phosphorylation and degradation by the proteasome, therefore allowing NF¦ÊB to translocate into the nucleus.

Go back
1386.0, 1178.0
19.0, 19.0

p43

p43

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e84

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c133 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 18064347 The IKK complex catalyzes I¦ÊB¦Á phosphorylation and degradation by the proteasome, therefore allowing NF¦ÊB to translocate into the nucleus.

Go back
1180.0, 1352.0
23.0, 23.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e69

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c134 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 18064347 Once in the nucleus, NF¦ÊB regulates the expression of pro-inflammatory cytokines and adhesion molecules.

Go back
1125.0, 1433.0
21.0, 21.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c136 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 18064347 Once in the nucleus, NF¦ÊB regulates the expression of pro-inflammatory cytokines and adhesion molecules.

Go back
1549.0, 353.0
21.0, 21.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000000030 e102

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c139 : 1
stoichiometry:c141 : 1

m18998*m73*m105*0.1

nodelay

--

true

0

false

PMID: 18064347 In addition, TLR2 and 4 uses a MyD88-independent pathway that involves PI3K and TRIF recruitment to the TLR/TIR domain.

Go back
1088.0, 296.0
23.0, 23.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000041125 MO000000030

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m12*m18998*m73*0.1

nodelay

--

true

0

false

PMID: 18064347 In addition, TLR2 and 4 uses a MyD88-independent pathway that involves PI3K and TRIF recruitment to the TLR/TIR domain.

Go back
1030.0, 514.0
19.0, 19.0

p48

p48

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e71

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c148 : 1
stoichiometry:c147 : 1

m977*m72*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 activates a TRIF-dependent pathway that induces the activation of IRF-3 and subsequently the production of type I IFN in response to LPS. PMID: 18064347, 12368275, 14519765 TLR4 utilizes the adaptors TRIF and TRAM independently of Mai and MyD88 to initiate the late phase of NF¦ÊB activation and also to induce the expression of IFN-? and other IFN-inducible genes via the transcription factor IRF-3.

Go back
882.0, 1226.0
19.0, 19.0

p49

p49

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e33 e38

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c149 : 1

m33*m38*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 activates a TRIF-dependent pathway that induces the activation of IRF-3 and subsequently the production of type I IFN in response to LPS.

Go back
1838.0, 303.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m3961*m15*0.1

nodelay

--

true

0

false

PMID: 18064347, 10644670, 11274165 TLR4 can also recognize taxol (a strong antitumor agent in humans) derived from Taxus brevifolia, and a respiratory syncytial virus fusion protein.

Go back
849.0, 933.0
21.0, 21.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR3 triggers a TIR domain-containing adaptor inducing IFN-¦Â (TRIF) signaling pathway independent of MyD88 recruitment.

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978.0, 1082.0
19.0, 19.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 e73

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c157 : 1
stoichiometry:c156 : 1

m76*m75*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR3 can also regulate IFN¦Á/¦Â production by IRFs, through a TRIF-dependent pathway that may also involve PI3K or TBK1/IKK-epsilon activation.

Go back
1064.0, 1116.0
23.0, 23.0

p52

p52

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76 e75

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c160 : 1
stoichiometry:c159 : 1

m78*m77*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR3 can also regulate IFN¦Á/¦Â production by IRFs, through a TRIF-dependent pathway that may also involve PI3K or TBK1/IKK-epsilon activation.

Go back
1520.0, 544.0
23.0, 23.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030 MO000041446

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c184 : 1
stoichiometry:c162 : 1

m73*m19314*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR3 can also regulate IFN¦Á/¦Â production by IRFs, through a TRIF-dependent pathway that may also involve PI3K or TBK1/IKK-epsilon activation.

Go back
1241.0, 1177.0
21.0, 21.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76 e78

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c166 : 1
stoichiometry:c165 : 1

m78*m80*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR3 can also regulate IFN¦Á/¦Â production by IRFs, through a TRIF-dependent pathway that may also involve PI3K or TBK1/IKK-epsilon activation.

Go back
790.0, 1370.0
19.0, 19.0

p55

p55

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e79 e77

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c167 : 1

m81*m79*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR3 can also regulate IFN¦Á/¦Â production by IRFs, through a TRIF-dependent pathway that may also involve PI3K or TBK1/IKK-epsilon activation.

Go back
754.0, 1438.0
19.0, 19.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e77

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c172 : 1
stoichiometry:c170 : 1

m93217*m79*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR3 can also regulate IFN¦Á/¦Â production by IRFs, through a TRIF-dependent pathway that may also involve PI3K or TBK1/IKK-epsilon activation.

Go back
1626.0, 278.0
19.0, 19.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018132 MO000019394

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m2828*m3961*0.1

nodelay

--

true

0

false

PMID: 18064347 The soluble product sTLR4 is an alternative splice variant of TLR4 that was shown to be expressed as a mechanism to inhibit LPS -mediated TNF¦Á production and NF¦ÊB activation, blocking MD-2 recruitment to the TLR4-CD14 complex.

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1522.0, 1006.0
19.0, 19.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e29 e104 e78 e109 e117

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c179 : 1
stoichiometry:c240 : 1
stoichiometry:c249 : 1
stoichiometry:c268 : 1
stoichiometry:c284 : 1
stoichiometry:c177 : 1

m69*m29*0.1

nodelay

--

true

0

false

PMID: 18064347 The soluble product sTLR4 is an alternative splice variant of TLR4 that was shown to be expressed as a mechanism to inhibit LPS -mediated TNF¦Á production and NF¦ÊB activation, blocking MD-2 recruitment to the TLR4-CD14 complex. PMID: 18064347, 12538665 The mechanism by which MyD88s reverts inflammation involves IRAK-4 sequestration by MyD88s that prevents further phosphorylation of IRAK-4 and IRAK-1 and activation of NF¦ÊB. PMID: 18064347, 12154357, 12052830 PI3K has been also implicated in TLRs signaling, suppressing both MAPKs and NF¦ÊB in response to LPS, thereby decreasing TNF¦Á production. PMID: 18064347, 15004556 A possible mechanism for ST2L immune modulation involves its interaction with molecular adaptors of TLR/IL-1 inflammatory pathways. ST2L can sequestrate MyD88 and Mai through their TIR domains, and therefore can block the effect of TLR4-mediated NF¦ÊB activation

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1491.0, 1311.0
25.0, 25.0

p59

p59

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e29 e78

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c182 : 1
stoichiometry:c230 : 1
stoichiometry:c181 : 1

m93309*m29*0.1

nodelay

--

true

0

false

PMID: 18064347 The soluble product sTLR4 is an alternative splice variant of TLR4 that was shown to be expressed as a mechanism to inhibit LPS -mediated TNF¦Á production and NF¦ÊB activation, blocking MD-2 recruitment to the TLR4-CD14 complex. PMID: 18064347, 12154357, 12052830 PI3K has been also implicated in TLRs signaling, suppressing both MAPKs and NF¦ÊB in response to LPS, thereby decreasing TNF¦Á production.

Go back
1851.0, 364.0
20.0, 20.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m3961*m17*0.1

nodelay

--

true

0

false

PMID: 18064347, 10644670, 11274165 TLR4 can also recognize taxol (a strong antitumor agent in humans) derived from Taxus brevifolia, and a respiratory syncytial virus fusion protein.

Go back
728.0, 832.0
23.0, 23.0

p60

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041446

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c183 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 18064347, 15502848 agonist activation of TLR3 may promote tyrosine phosphorylation that allows phosphatidylinositol 3-kinase (PI3K) recruitment, Akt activation and finally IRF-3 phosphorylation.

Go back
715.0, 1027.0
17.0, 17.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e85 e78

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c187 : 1

m87*m80*0.1

nodelay

--

true

0

false

PMID: 18064347, 15502848 agonist activation of TLR3 may promote tyrosine phosphorylation that allows phosphatidylinositol 3-kinase (PI3K) recruitment, Akt activation and finally IRF-3 phosphorylation.

Go back
685.0, 1100.0
19.0, 19.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c190 : 1
stoichiometry:c189 : 1

m89*m88*0.1

nodelay

--

true

0

false

PMID: 18064347, 15502848 agonist activation of TLR3 may promote tyrosine phosphorylation that allows phosphatidylinositol 3-kinase (PI3K) recruitment, Akt activation and finally IRF-3 phosphorylation.

Go back
1108.0, 572.0
23.0, 23.0

p63

p63

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e87

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c191 : 1
stoichiometry:c193 : 1
stoichiometry:c192 : 1

m977*m90*0.1

nodelay

--

true

0

false

PMID: 18064347, 15502848 agonist activation of TLR3 may promote tyrosine phosphorylation that allows phosphatidylinositol 3-kinase (PI3K) recruitment, Akt activation and finally IRF-3 phosphorylation.

Go back
1825.0, 873.0
21.0, 21.0

p64

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e88 e104 e106

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c239 : 1
stoichiometry:c257 : 1
stoichiometry:c194 : 1

m91*0.1

nodelay

--

true

0

false

PMID: 18064347 A crucial event in pro-inflammatory signaling activation is the interaction of IRAK-4 with MyD88-ID domain that promotes, after recruitment to the receptor TIR domain, the phosphorylation of IRAK-1. PMID: 18064347, 12538665 The mechanism by which MyD88s reverts inflammation involves IRAK-4 sequestration by MyD88s that prevents further phosphorylation of IRAK-4 and IRAK-1 and activation of NF¦ÊB. PMID: 18064347, 10854325 Tollip is recruited to the TIR domain and decreases IRAK-1 phosphorylation upon LPS activation. IRAK-1 activation by MyD88 promotes Tollip dissociation from the TIR domain.

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1840.0, 936.0
23.0, 23.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e89 MO000000212 MO000016569 MO000016566

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c196 : 1
stoichiometry:c242 : 1
stoichiometry:c244 : 1
stoichiometry:c197 : 1

m92*m183*0.1

nodelay

--

true

0

false

PMID: 18064347 Once IRAK-1 is phosphorylated TRAF6 is recruited to the TLR complex. PMID: 18064347, 12150927 IRAK-M and IRAK-2 block pro-inflammatory cytokine expression by dissociating the complex formed by MyD88-IRAK-l/-4 and IRAK-TRAF6. IRAK-M -/- mice show an over-production of inflammatory cytokines in response to LPS and bacterial DNA-like CpG motifs .

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1839.0, 1019.0
17.0, 17.0

p66

p66

cso30:i:ME_Dissociation

cso30:i:CC_Extracellular

--

e90

e91 e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m93*0.1

nodelay

--

true

0

false

PMID: 18064347, 11259596 IRAK-1 and TRAF6 dissociate from the TIR/MyD88/IRAK-4 complex and interact with membrane-associated proteins, such as TAK1 (transforming growth factor-(?-activated kinase 1), TAB1 (transforming growth factor-(?-activated protein kinase 1-binding protein 1) and TAB2 that are part of the multicomplex IRAK-1-TRAF6-TAK1-TAB1-TAB2.

Go back
1834.0, 1070.0
19.0, 19.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e91 e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m94*m95*0.1

nodelay

--

true

0

false

PMID: 18064347, 11259596 IRAK-1 and TRAF6 dissociate from the TIR/MyD88/IRAK-4 complex and interact with membrane-associated proteins, such as TAK1 (transforming growth factor-(?-activated kinase 1), TAB1 (transforming growth factor-(?-activated protein kinase 1-binding protein 1) and TAB2 that are part of the multicomplex IRAK-1-TRAF6-TAK1-TAB1-TAB2.

Go back
1806.0, 1138.0
19.0, 19.0

p68

p68

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 18064347, 12242293 When TAK1 and TAB2 become phosphorylated they induce IRAK-1 dissociation from the complex and further IKKs and MAPKs activation.

Go back
1817.0, 1201.0
21.0, 21.0

p69

p69

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e94

e95 e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 18064347, 12242293 When TAK1 and TAB2 become phosphorylated they induce IRAK-1 dissociation from the complex and further IKKs and MAPKs activation.

Go back
1841.0, 430.0
23.0, 23.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019394 MO000020119

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m3961*m4645*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 is activated by endogenous ligands, such as heat shock protein 60 (HSP60), HSP70, fibronectin, hyaluronic acid, fibrinogen and heparan sulfate.

Go back
1397.0, 653.0
21.0, 21.0

p70

p70

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000248 e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c211 : 1
stoichiometry:c210 : 1

m207*m101*0.1

nodelay

--

true

0

false

PMID: 18064347, 15147900, 11460167 Recent studies showed that TRAF6 can bind ubiquitin-conjugating enzymes Ubcl3 and UevlA, that are critical in the activation of TAK1 -mediated phosphorylation of IKK and MKK (MAPK Kinases)

Go back
1825.0, 1277.0
21.0, 21.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e95 MO000022136 e97

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c213 : 1
stoichiometry:c214 : 1
stoichiometry:c215 : 1

m98*m6443*m100*0.1

nodelay

--

true

0

false

PMID: 18064347, 15147900, 11460167 Recent studies showed that TRAF6 can bind ubiquitin-conjugating enzymes Ubcl3 and UevlA, that are critical in the activation of TAK1 -mediated phosphorylation of IKK and MKK (MAPK Kinases)

Go back
1258.0, 958.0
19.0, 19.0

p72

p72

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e100 e98 e78

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c218 : 1
stoichiometry:c248 : 1
stoichiometry:c217 : 1

m103*m101*0.1

nodelay

--

true

0

false

PMID: 18064347, 15147900, 11460167 Recent studies showed that TRAF6 can bind ubiquitin-conjugating enzymes Ubcl3 and UevlA, that are critical in the activation of TAK1 -mediated phosphorylation of IKK and MKK (MAPK Kinases). PMID: 18064347, 12154357, 12052830 PI3K has been also implicated in TLRs signaling, suppressing both MAPKs and NF¦ÊB in response to LPS, thereby decreasing TNF¦Á production.

Go back
1281.0, 861.0
21.0, 21.0

p73

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e66 e99

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c221 : 1
stoichiometry:c220 : 1

m66*m102*0.1

nodelay

--

true

0

false

PMID: 18064347 The IKK complex catalyzes I¦ÊB¦Á phosphorylation and degradation by the proteasome, therefore allowing NF¦ÊB to translocate into the nucleus.

Go back
1514.0, 38.0
19.0, 19.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e29 MO000041132

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1
stoichiometry:c224 : 1

m29*m19005*0.1

nodelay

--

true

0

false

PMID: 18064347 TRAM, like Mai, acts as a bridge to couple TRIF to TLR4 and is absolutely required for TLR4 mediated responses.

Go back
1187.0, 1447.0
25.0, 25.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G014880

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c225 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 activation by LPS may induce the expression of the TRIF-related adaptor molecule (TRAM/TICAM-2) that binds to TLR4 and to TRIF.

Go back
1345.0, 1133.0
21.0, 21.0

p76

p76

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G014880 e29

MO000041132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c227 : 1

m96947*m29*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 activation by LPS may induce the expression of the TRIF-related adaptor molecule (TRAM/TICAM-2) that binds to TLR4 and to TRIF.

Go back
1164.0, 636.0
23.0, 23.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e78

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1
stoichiometry:c250 : 1

m12*m80*0.1

nodelay

--

true

0

false

PMID: 18064347, 11101877 Stimulation of TLR2 expressing cells with Staphylococcus aureus promotes PI3K recruitment to the TIR domain and induces transactivation of the NF¦ÊB subunit p65 by a mechanism that seems to be independent of I¦ÊB¦Á proteasomic degradation.

Go back
689.0, 1489.0
21.0, 21.0

p78

p78

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e38

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c233 : 1

m93217*m38*0.1

nodelay

--

true

0

false

PMID: 18064347, 12368275, 14519765 TLR4 utilizes the adaptors TRIF and TRAM independently of Mai and MyD88 to initiate the late phase of NF¦ÊB activation and also to induce the expression of IFN-? and other IFN-inducible genes via the transcription factor IRF-3.

Go back
1454.0, 46.0
19.0, 19.0

p79

p79

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e49 e104

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c238 : 1
stoichiometry:c236 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18064347, 12538665 The mechanism by which MyD88s reverts inflammation involves IRAK-4 sequestration by MyD88s that prevents further phosphorylation of IRAK-4 and IRAK-1 and activation of NF¦ÊB.

Go back
1828.0, 496.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000021614

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m3961*m5956*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 is activated by endogenous ligands, such as heat shock protein 60 (HSP60), HSP70, fibronectin, hyaluronic acid, fibrinogen and heparan sulfate.

Go back
1209.0, 401.0
21.0, 21.0

p80

p80

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000331 e78

MO000017272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c247 : 1
stoichiometry:c245 : 1

m290229*m80*0.1

nodelay

--

true

0

false

PMID: 18064347 PI3K is an enzyme that catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol 3,4,5-trisphosphate (PIP3).

Go back
1410.0, 1118.0
19.0, 19.0

p81

p81

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e105

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c253 : 1
stoichiometry:c252 : 1

m69*m108*0.1

nodelay

--

true

0

false

PMID: 18064347, 11101877 Stimulation of TLR2 expressing cells with Staphylococcus aureus promotes PI3K recruitment to the TIR domain and induces transactivation of the NF¦ÊB subunit p65 by a mechanism that seems to be independent of I¦ÊB¦Á proteasomic degradation.

Go back
672.0, 308.0
23.0, 23.0

p82

p82

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019406 e29

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1
stoichiometry:c256 : 1

m3973*m29*0.1

nodelay

--

true

0

false

PMID: 18064347, 10854325 Tollip is recruited to the TIR domain and decreases IRAK-1 phosphorylation upon LPS activation. IRAK-1 activation by MyD88 promotes Tollip dissociation from the TIR domain.

Go back
385.0, 273.0
21.0, 21.0

p83

p83

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e106 e89

MO000019406 e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c261 : 1
stoichiometry:c259 : 1
stoichiometry:c260 : 1

m109*m92*0.1

nodelay

--

true

0

false

PMID: 18064347, 10854325 Tollip is recruited to the TIR domain and decreases IRAK-1 phosphorylation upon LPS activation. IRAK-1 activation by MyD88 promotes Tollip dissociation from the TIR domain.

Go back
661.0, 457.0
21.0, 21.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e107 MO000020461

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c263 : 1
stoichiometry:c264 : 1

m110*m4947*0.1

nodelay

--

true

0

false

PMID: 18064347, 12514169, 12527755 NOD2 protein is constituted by two caspase recruitment domains (CARD), a NOD region and a tripartite domain, consisting of a C-terminal LRR. This last domain recognizes and reacts to the bacterial component muramyl dipeptide (MDP), and is the site with major genetic variability.

Go back
385.0, 545.0
21.0, 21.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000044794 MO000016573

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c266 : 1
stoichiometry:c267 : 1

m22464*m1572*0.1

nodelay

--

true

0

false

PMID: 18064347, 15004556 A possible mechanism for ST2L immune modulation involves its interaction with molecular adaptors of TLR/IL-1 inflammatory pathways. ST2L can sequestrate MyD88 and Mai through their TIR domains, and therefore can block the effect of TLR4-mediated NF¦ÊB activation

Go back
381.0, 973.0
21.0, 21.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e112 e114

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c277 : 1
stoichiometry:c276 : 1

m115*m117*0.1

nodelay

--

true

0

false

PMID: 18064347, 12925853, 15866876 SIGIRR interacts with IL-1R and TLR4 in a ligand-dependent manner and inhibits their signaling.

Go back
404.0, 788.0
23.0, 23.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066718 e29

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c273 : 1
stoichiometry:c274 : 1

m41575*m29*0.1

nodelay

--

true

0

false

PMID: 18064347, 12925853, 15866876 SIGIRR interacts with IL-1R and TLR4 in a ligand-dependent manner and inhibits their signaling.

Go back
1013.0, 1505.0
21.0, 21.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e29 e110

G010693

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c271 : 1
stoichiometry:c270 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18064347, 11359817 In LPS-activated macrophages, ST2s downregulates TLR4 mRNA expression.

Go back
349.0, 1121.0
30.0, 30.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e113 MO000066718

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c278 : 1
stoichiometry:c280 : 1
stoichiometry:c279 : 1

m116*m41575*0.1

nodelay

--

true

0

false

PMID: 18064347, 12925853, 15866876 SIGIRR interacts with IL-1R and TLR4 in a ligand-dependent manner and inhibits their signaling.

Go back
1890.0, 547.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000017549

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m3961*m2341*0.1

nodelay

--

true

0

false

PMID: 18064347 TLR4 is activated by endogenous ligands, such as heat shock protein 60 (HSP60), HSP70, fibronectin, hyaluronic acid, fibrinogen and heparan sulfate.

Go back
316.0, 628.0
23.0, 23.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000044794 e116

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c282 : 1
stoichiometry:c283 : 1

m22464*m119*0.1

nodelay

--

true

0

false

PMID: 18064347, 15004556 A possible mechanism for ST2L immune modulation involves its interaction with molecular adaptors of TLR/IL-1 inflammatory pathways. ST2L can sequestrate MyD88 and Mai through their TIR domains, and therefore can block the effect of TLR4-mediated NF¦ÊB activation

Go back
979.0, 134.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.2132919606805, 125.32630567035159

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.0, 780.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0857798247018, 275.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.165938548473, 562.0971758667378

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 559.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.6437975294531, 272.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1419.9434262467255, 90.35496820249521

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1374.0, 93.89486284136274

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1224.4731353755344, 211.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1408.0, 86.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1232.6331719007019, 309.3947205962986

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.0, 78.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1124.0, 268.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1451.0, 72.9342229330722

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1225.0, 210.94967607067775

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 200.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.9780174696468, 261.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.9274807168084, 290.0747322850975

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.6891502680003, 202.3880825758082

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1117.0, 272.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1620.0, 707.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1749.0, 874.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.1411509102887, 118.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1232.0, 824.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1336.0, 824.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1321.0, 731.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1349.7171557102204, 539.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1327.0242219551483, 628.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1321.0, 213.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1302.8819498499408, 537.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1291.0, 613.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.0, 197.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1396.0, 839.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1754.0, 314.1904222235703

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1405.0, 930.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1396.0, 930.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1410.0, 1021.2610398126205

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1301.1599912745378, 1197.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1202.0, 1375.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1210.2188961382433, 1327.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1136.0, 1454.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1152.1295323450063, 1332.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1485.0, 379.65685424949237

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1560.1701742519247, 212.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1867.0, 314.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1577.7997164282071, 349.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1426.2394443073426, 209.04551266231854

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1115.2820457032788, 205.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1118.4202640769977, 314.98992993690786

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1118.9826896020998, 309.52599117533214

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.0, 193.4548892026539

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1003.0, 379.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.4577520188942, 533.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.907883951425, 201.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
709.6144659505665, 1239.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1758.8810322322581, 321.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
908.7771409562145, 1239.8751209420122

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
894.079122071659, 631.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
825.0, 900.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.2406579788229, 470.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.9266413443544, 935.0809056378665

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
993.4323213903456, 1035.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.0, 1083.0496697522246

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
783.0, 943.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
979.0, 1129.9347299805393

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 1105.1513543886333

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1754.0, 324.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1076.0, 1093.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1542.8417989142883, 365.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1532.0, 567.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.9055008250352, 854.0390665203037

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
979.0, 1142.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1165.9792745494692, 1111.3149107106394

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1261.7714027725426, 685.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
634.0, 1380.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.0, 1380.0

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.1967211975888, 1106.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1879.0, 374.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.0, 1448.0

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.9940239794695, 1448.3091611483774

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
778.8952103383059, 1107.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1638.1193153738147, 186.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1652.7156662946952, 293.1138811766288

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1645.0, 236.60622895432743

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1894.9979204573588, 220.12896517604383

c176

c176

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1518.8275367176875, 1025.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1412.8508095013187, 1167.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1534.0217137583716, 205.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1760.0667921655595, 379.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1330.0, 1328.606355389667

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1516.0, 1326.0

c181

c181

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1464.1146595500513, 205.0

c182

c182

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
727.1723892887157, 855.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 565.3577878415823

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
724.0, 960.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.2691276927487, 674.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.352465419694, 956.2636750760037

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 1071.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0, 1119.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1753.0, 334.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.0, 949.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 379.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1086.4605149764209, 595.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.0, 601.4918357268102

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1752.3955088087835, 889.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1745.0, 930.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1506.0, 408.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1757.4837767493345, 953.0

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1750.0, 996.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1693.0, 1028.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.2063309876478, 132.07405281892238

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1872.0, 442.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1461.417458004189, 209.23332432492862

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1685.0, 1033.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1668.0, 1080.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1694.6495996440594, 1083.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1687.0, 1134.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1688.819662394928, 1150.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1681.0, 1183.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1677.8278328271654, 1214.0

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1621.9720945662416, 1194.6676138306705

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1384.0, 539.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1763.9814649373425, 449.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1408.0, 674.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1416.5549027825127, 681.1667751608993

c211

c211

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1670.0, 1251.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1604.0, 1284.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1553.0, 1246.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1755.5183473879074, 1292.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1241.0, 934.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1268.0, 977.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1283.3690223641286, 979.8410282095058

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1232.0, 832.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1746.0, 334.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1302.0, 833.3239548604411

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1307.6568542494924, 771.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1534.1820050561153, 63.81988516843405

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1405.0, 64.65653141987259

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1527.0, 57.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1210.0, 1472.0

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1206.4357568706914, 205.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1357.0, 479.9838993639337

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1270.0, 1161.8035280165416

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1361.0265035038608, 205.0

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1858.9990236162776, 506.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1505.1659910767462, 685.0

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1177.4850870793994, 208.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.9914403690368, 648.3699740911591

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
632.8982868839523, 1460.051374836607

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.8997269882999, 1459.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
705.4013878696029, 631.0

c235

c235

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1466.0, 65.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1497.0, 210.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 64.00761315101109

c238

c238

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
825.0, 437.0

c239

c239

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1759.90019924613, 515.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
825.0, 439.0

c240

c240

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1553.0, 710.9908919356496

c241

c241

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1561.0, 962.6173786379112

c242

c242

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1483.0, 710.155201160714

c243

c243

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1487.0, 883.0

c244

c244

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1208.419724221888, 422.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1114.0, 385.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1236.2231130617254, 425.0272123310024

c247

c247

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1279.6222486253048, 685.0

c248

c248

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1532.0, 685.0

c249

c249

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1748.0, 334.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.3485451434642, 362.16210124355126

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1401.0, 1070.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1429.0, 1131.0

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 365.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
635.0, 324.89081263318

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.9151338096605, 186.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.38204335509624, 247.08308869536373

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.0, 245.0

c257

c257

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
413.0363475688874, 246.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 286.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1919.0, 558.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 185.6576986798622

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.20626446902247, 292.474154919186

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
644.0, 447.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.0, 469.9922778767137

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 434.4047579666174

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.5442332670891, 504.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
413.76785342344726, 271.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 558.0

c267

c267

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.0, 579.0

c268

c268

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1032.212462703468, 205.0

c269

c269

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1760.3082909118054, 563.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.0, 1526.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.0, 1529.681215753048

c271

c271

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
433.87434307527764, 768.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
434.1072830696581, 191.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.0, 805.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.2862551987165, 945.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 990.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
359.0, 998.2289589627687

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.50986776965385, 1055.0

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
379.0, 1139.0

c279

c279

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1906.0, 662.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.4836195824118, 775.0

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.8543831840155, 508.0

c281

c281

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.8458696916044, 589.0

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 641.0

c283

c283

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
506.0, 666.0

c284

c284

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1757.9055512611653, 664.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
943.4688030358325, 126.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1744.0, 334.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1757.8147142872076, 728.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1742.0, 334.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1882.0, 726.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1741.0, 334.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1874.999702751407, 798.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1755.9079041220812, 801.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1896.0, 70.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1913.0554533493828, 104.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1774.4536640138874, 92.90566563253238

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 97.69899032297964

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1670.0, 84.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1662.0390665203035, 100.90550082503523

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1661.0, 94.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1748.0, 220.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1815.0, 224.9057722223812

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1751.4806698104644, 225.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1744.0, 221.92515233577853

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1744.0, 178.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1630.9489515344314, 186.90231341742194

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1826.0, 77.15541752799933

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.4063251078692, 97.87542060406786

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1677.7806311332354, 173.86058570577367

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
671.0, 88.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.1513543886333, 122.35316024014446

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
705.1513543886333, 115.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
875.0, 664.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 661.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0561610125071, 675.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.0, 595.7639112242477

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 541.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.0, 589.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1081.0, 90.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
710.0, 1300.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
854.9993210341487, 1300.1042256812266

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
759.0, 649.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.0, 676.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.7445414019716, 541.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
597.0, 683.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
981.9469381668789, 379.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.4062548214393, 550.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.0, 546.9331579092562

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
936.4010917717399, 379.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1146.0, 101.90927411784803

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 530.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 533.0069486298408

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.0, 636.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1022.0, 777.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.7777713001234, 842.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.0667921655595, 769.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.0, 810.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 735.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1287.0, 1413.9664153458475

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1499.0, 1415.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.2792613278382, 48.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1488.0, 1453.8561812775845

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1287.0, 1444.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1024.0, 897.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
982.0, 631.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.0, 853.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 888.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.9975603804354, 858.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1597.8423501596155, 85.95552928525788

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1570.0, 85.92137617704611

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1544.8918853797065, 78.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1163.0, 94.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1218.0, 97.20891200093013

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1309.6075989880128, 91.50994851562774

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1277.4871333448389, 91.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
705.0, 56.561147119052194

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
918.5847422051386, 50.5439508017235

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.1143024185452, 50.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 588.7912833430186

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.1365385794043, 587.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1190.2453078246876, 278.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.6757168780139, 739.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back