1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18086372.csml convertedTime:2009.07.01.14:51

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The role of viral nucleic acid recognition in dendritic cells for innate andadaptive antiviral immunity.
Authors Eisenacher K, Steinberg C, Reindl W, Krug A.
Affiliation Department of Medicine II, Technical University, Ismaninger Str 22, D-81675,Munich, Germany.
Abstract Dendritic cells which are located at the interface of innate and adaptiveimmunity are targets for infection by many different DNA and RNA viruses.Dendritic cell subpopulations express specific nucleic acid recognitionreceptors belonging to the Toll-like receptor family (TLR3, 7, 8, 9) and thecytosolic RNA helicase family (RIG-I, MDA5, LGP2). Activation of dendritic cellsby viral DNA and RNA via these receptors is essential for triggering the innateantiviral immune response and shaping the ensuing adaptive antiviral immunity.This review will summarize our current knowledge of viral nucleic acidrecognition and signaling by Toll-like receptors and RNA helicases focusing onrecent evidence for their specific functions in antiviral defense in vivo.
PMID 18086372
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010453:IFN-gamma G010514:iNOS G010657:IL-12 p40 G010713:IRF-7 G010963:TLR3 G016992:IFN-alpha1 MO000000058:NF-kappaB MO000000065:RIP1 MO000000077:MAPKs MO000000212:TRAF6 MO000000213:IRAK MO000000265:chemokines MO000007685:IRF-1 MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016608:IKK-i MO000016658:IFN Type I MO000016659:IFNalpha1 MO000016661:IKK-alpha:IKK-beta:IKK-gamma MO000016665:IFNgamma MO000016834:IFNRs MO000016899:FADD MO000016907:Caspases MO000016963:TRAF3 MO000017264:IL-8 MO000017265:IL-12 MO000019326:TANK MO000019331:TBK1 MO000019387:cytokines MO000019398:TLR3 MO000019479:protein remnants MO000022224:dsRNA MO000033676:IL-12R MO000039077:IRAK-4 MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041441:dsRNA:TLR3:TRIF:TBK1:IKK-i MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000094908:IPS-1 MO000103999:MDA-5 e1: e10: e100:dsRNA: MDA-5 e101:LGP2 e102:dsRNA: LGP2 e103:dsRNA: RIG-1: IPS-1 e104:TBK1: IKK-i e105:LGP2: RIG-1 e106:dsRNA: RIG-1: IPS-1: TRAF3 e107:dsRNA: RIG-1: IPS-1: TBK1: IKK-i e108:dsRNA: RIG-1: IPS-1: TBK1: IKK-i: IRF-3 e109:dsRNA: RIG-1: IPS-1: RIP1: FADD e11: e110:TBK1: IKK-i{activated} e111:dsRNA: RIG-1: IPS-1: TRAF6 e112:5'-triphosphate ssRNA e113:5'-triphosphate ssRNA: RIG-1 e114:card domain e115:C-terminal helicase domain e116:C-terminal helicase domain e117:MDA-5 e118:RIG-1 e119:LGP2 e12:ssRNA e120:dsRNA: MDA-5: IPS-1 e121:dsRNA: MDA-5: IPS-1: TBK1: IKK-i e122:NS1 e123:dsRNA: NS1 e124:dsRNA: NS1: RIG-1: IPS-1 e125:RSV NS1 e126:RSV NS2 e127:phosphoprotein P e128:V protein e129:V rpotein: MDA-5 e13:CpG DNA e130:poliovirus protin e131: e132: e133: e134: e135: e136: e137: e138: e139: e14:ssRNA: TLR7 e140:NS3/4A e141:e141 e142:ligand: TLR e143:MAPKs{activated} e144:chemokine e15:ssRNA: TLR8 e16:CpG DNA: TLR9 e17:poly U RNA e18:Poly U RNA: TLR7 e19:Poly U RNA: TLR8 e2: e20:siRNA e21:siRNA: TLR8 e22:siRNA: TLR7 e23:imidazoquinoline e24:imidazoquinoline: TLR7 e25:imidazoquinoline: TLR8 e26:poly I: C e27:poly I: C: TLR3 e28:dsRNA:TLR3:TRIF: TRAF3 e29:IRF-7: IRF-7{p} e3: e30:IRF-3: IRF-3{p} e31:IRF-3{p}: IRF-7{p} e32:IRF-7: IRF-7{p} e33:IRF-3{p}: IRF-7{p} e34:IRF-3: IRF-3{p} e35:dsRNA:TLR3:TRIF: RIP1 e36:dsRNA:TLR3:TRIF: TRAF6 e37:TAK1{activated} e38:IKK-alpha:IKK-beta:IKK-gamma{activated} e39:IkappaB: NF-kappaB e4: e40:NF-kappaB{nuclear} e41:IFN Type I e42:IFN inducible genes e43:IL-8 e44:ODN e45:ODN: TLR9 e46:CpG DNA: TLR9: MyD88 e47:CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6: IRF-7 e48:CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6 e49:cytokine e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:costimulatory molecule genes e64:IFN Type I: IFNRs e65:IRF-1{activated} e66:IL-12p35 e67:CpG-B ODN e68: e69: e7: e70: e71: e72: e73: e74: e75: e76: e77: e78: e79: e8: e80: e81: e82: e83: e84: e85: e86: e87: e88: e89:IL-12: IL-12R e9: e90:IL-8 receptor e91:IL-8: IL-8 receptor e92:ssRNA: TLR7: MyD88 e93:ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7 e94:ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6 e95:ssRNA: TLR8: MyD88 e96:ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7 e97:ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6 e98:RIG-1 e99:dsRNA: RIG-1

Process

p1 p10 p100 p101 p102 p103 p104 p105 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
613.0, 1169.0
29.0, 29.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p50 p83 p96

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
692.0, 1144.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
1468.0, 1392.0
32.0, 32.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p56 p58

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
594.0, 1202.0
31.0, 31.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p51

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
646.0, 1110.0
28.0, 28.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
593.0, 1413.0
29.0, 29.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p48

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
724.0, 1425.0
30.0, 30.0

TLR3

--

G010963

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m93849

10

false

infinite

0

unit false false false
TRANSFACG010963

--

Go back
910.0, 1466.0
28.0, 28.0

IFN-alpha1

--

G016992

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m98717

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
886.0, 1026.0
28.0, 28.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p30

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
640.0, 496.0
28.0, 28.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24 p78

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1139.0, 1003.0
33.0, 33.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p103

true true true true

csml-variable:Double

m145

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
694.0, 598.0
28.5, 28.5

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p41 p61 p64 p81

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
732.5, 893.0
26.0, 26.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p61 p64

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1154.0, 1398.0
27.0, 27.0

chemokines

--

MO000000265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p104

--

true true true true

csml-variable:Double

m211

10

false

infinite

0

unit false false false
TRANSPATHMO000000265

--

Go back
464.0, 1011.0
28.0, 28.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
816.0, 524.0
31.0, 31.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p73 p95

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
770.0, 439.0
30.0, 30.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p16 p41 p61 p64 p93

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
730.0, 846.0
31.0, 31.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p60 p63

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
863.0, 727.0
34.0, 34.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
710.0, 434.0
31.5, 31.5

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p92

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
149.0, 1389.0
30.0, 30.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46 p70 p79

p47

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
843.0, 1623.0
25.0, 25.0

IFNalpha1

--

MO000016659

cso30:c:Protein

cso30:i:CC_CellComponent

--

p77

--

true true true true

csml-variable:Double

m1635

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
885.0, 845.0
30.0, 30.0

IKK-alpha:IKK-beta:IKK-gamma

--

MO000016661

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p28 p82 p94 p102

true true true true

csml-variable:Double

m1637

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1388.0, 1340.0
31.0, 31.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56 p58

p59

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
232.0, 1516.0
32.0, 32.0

IFNRs

--

MO000016834

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m1771

10

false

infinite

0

unit false false false
TRANSPATHMO000016834

--

Go back
1157.0, 697.0
29.0, 29.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
840.0, 220.0
31.5, 31.5

Caspases

--

MO000016907

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85 p100

true true true true

csml-variable:Double

m1822

10

false

infinite

0

unit false false false
TRANSPATHMO000016907

--

Go back
499.0, 300.0
27.0, 27.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p74

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1310.0, 1182.0
28.0, 28.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p57

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
1300.0, 1050.0
32.0, 32.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p54

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1132.0, 775.0
30.5, 30.5

TANK

--

MO000019326

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80

true true true true

csml-variable:Double

m3897

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000019326

--

Go back
658.0, 447.0
29.0, 29.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p92

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
309.0, 1257.0
30.0, 30.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p71 p105

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
344.0, 372.0
27.5, 27.5

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p12

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1018.0, 974.0
28.0, 28.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29 p100

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
589.0, 57.0
29.5, 29.5

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p66 p67 p68 p97

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1348.0, 1048.0
32.0, 32.0

IL-12R

--

MO000033676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m12340

10

false

infinite

0

unit false false false
TRANSPATHMO000033676

--

Go back
715.0, 1011.0
21.0, 21.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p61 p64

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
390.0, 299.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
441.0, 349.0
34.0, 34.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p14 p24 p25

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
561.0, 441.0
34.0, 34.0

dsRNA:TLR3:TRIF:TBK1:IKK-i

--

MO000041441

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16 p17

true true true true

csml-variable:Double

m19309

10

false

infinite

0

unit false false false
TRANSPATHMO000041441

--

Go back
390.0, 362.0
32.0, 32.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p5

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
822.0, 594.0
36.0, 36.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p76 p95

p19 p20

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
789.0, 477.0
34.0, 34.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16 p42 p62 p65 p93

p18 p20

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
303.0, 648.0
27.5, 27.5

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p7 p9 p11

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
300.0, 884.0
27.5, 27.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p39

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
297.0, 562.0
27.0, 27.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p6 p8 p10

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
816.0, 372.0
32.0, 32.0

IPS-1

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69 p91 p101

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
706.0, 218.0
27.0, 27.0

MDA-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67 p85 p99 p100

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
186.34245598341363, 199.15652946572055
1088.0717876556314, 1573.801096683933

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
196.8395769403567, 356.9480717836596
955.4421382934134, 1338.8667774068574

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
696.625, 265.5
30.919971671388105, 37.861189801699716

dsRNA: MDA-5

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p91

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
469.5, 253.125
36.644194002817464, 22.597252968404106

LGP2

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p68 p72

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
316.625, 233.5
29.8993084485919, 36.61139810031661

dsRNA: LGP2

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p68

p70 p71

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1065.875, 368.5
27.98866764543953, 39.05395485410167

dsRNA: RIG-1: IPS-1

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

p75 p74 p78 p81 p98

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1121.625, 299.5
31.00979003499417, 37.97117147142143

TBK1: IKK-i

--

e104

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p75 p80

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
621.625, 338.5
28.87047992001333, 35.351608065322445

LGP2: RIG-1

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

p66

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
1075.875, 605.5
32.25, 45.0

dsRNA: RIG-1: IPS-1: TRAF3

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p77 p80

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
1126.875, 417.5
29.069783446503944, 40.5624885300055

dsRNA: RIG-1: IPS-1: TBK1: IKK-i

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p75 p76

p73

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1133.875, 469.5
29.606395668930077, 41.311249770600114

dsRNA: RIG-1: IPS-1: TBK1: IKK-i: IRF-3

--

e108

cso30:c:Complex

cso30:i:CC_Cytosol

--

p73

p76

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1103.875, 713.5
32.25, 45.0

dsRNA: RIG-1: IPS-1: RIP1: FADD

--

e109

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

p79

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
298.3464813304762, 362.0614984924051
359.79113648000293, 600.668253275937

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
1135.625, 823.5
31.00979003499417, 37.97117147142143

TBK1: IKK-i{activated}

--

e110

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

--

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
1131.875, 877.5
32.25, 45.0

dsRNA: RIG-1: IPS-1: TRAF6

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

p82

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
516.0, 41.5
39.769673704414586, 21.873320537428025

5'-triphosphate ssRNA

--

e112

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p84

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
414.375, 218.5
18.356336329752246, 35.52839289629467

5'-triphosphate ssRNA: RIG-1

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
796.5, 293.25
39.70142977291842, 22.497476871320437

card domain

--

e114

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
828.5, 269.25
38.313708999158955, 21.711101766190076

C-terminal helicase domain

--

e115

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p85

p86

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
930.5, 1429.25
38.313708999158955, 21.711101766190076

C-terminal helicase domain

--

e116

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p86

p89

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
792.5, 1461.0
39.550173010380625, 21.093425605536332

MDA-5

--

e117

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p90

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
720.5, 1469.0
39.965397923875436, 21.314878892733564

RIG-1

--

e118

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p87

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
720.5, 1501.0
39.965397923875436, 21.314878892733564

LGP2

--

e119

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p88

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
149.0, 646.5
42.91746641074856, 23.604606525911706

ssRNA

--

e12

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p1 p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
767.875, 326.5
24.59538447421545, 34.31914112681226

dsRNA: MDA-5: IPS-1

--

e120

cso30:c:Complex

cso30:i:CC_Cytosol

--

p91

p94 p92 p96

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
749.875, 372.5
27.578317122407782, 38.48137272894109

dsRNA: MDA-5: IPS-1: TBK1: IKK-i

--

e121

cso30:c:Complex

cso30:i:CC_Cytosol

--

p92

p93 p95

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
744.5, 20.125
31.560000000000002, 23.669999999999995

NS1

--

e122

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p97 p98

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
849.625, 41.5
29.499208465255794, 36.12147975337444

dsRNA: NS1

--

e123

cso30:c:Complex

cso30:i:CC_Extracellular

--

p97

p4 p66 p67 p68

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
1059.875, 313.5
32.25, 45.0

dsRNA: NS1: RIG-1: IPS-1

--

e124

cso30:c:Complex

cso30:i:CC_Cytosol

--

p98

p75

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
1316.5, 474.125
28.999999999999996, 21.750000000000004

RSV NS1

--

e125

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p17 p76 p95

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
1314.5, 523.125
31.080000000000002, 23.309999999999995

RSV NS2

--

e126

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p17 p76 p95

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
1313.5, 571.125
29.479999999999997, 22.11

phosphoprotein P

--

e127

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p76 p95

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
916.5, 52.125
31.240000000000002, 23.429999999999996

V protein

--

e128

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p99

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
917.625, 246.5
27.898808531911346, 34.161806365605734

V rpotein: MDA-5

--

e129

cso30:c:Complex

cso30:i:CC_Cell_WithoutCellWall_

--

p99

p67

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
131.5, 870.125
45.0, 15.75

CpG DNA

--

e13

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
972.5, 96.125
31.720000000000002, 23.79

poliovirus protin

--

e130

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p100

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
843.6795498792795, 375.47412247387234
0.5888902593379355, 0.588890259337934

--

e131

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false true false

--

Go back
842.1337129485175, 371.09425117004645
3.7725782238836523, 6.790640802990551

--

e132

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false true false

--

Go back
831.1731825273008, 346.2171684867393
32.948018720748664, 51.680561622464566

--

e133

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false true false

--

Go back
825.7261310452416, 341.5008190327611
43.84212168486714, 61.113260530420796

--

e134

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false true false

--

Go back
825.8589859594382, 341.63367394695763
43.576411856474, 60.84755070202767

--

e135

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false true false

--

Go back
825.8589859594382, 341.63367394695763
43.576411856474, 60.84755070202767

--

e136

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false true false

--

Go back
831.3060374414974, 346.35002340093587
32.682308892355536, 51.41485179407141

--

e137

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false true false

--

Go back
825.8589859594382, 341.63367394695763
43.576411856474, 60.84755070202767

--

e138

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false true false

--

Go back
831.3060374414974, 346.35002340093587
32.682308892355536, 51.41485179407141

--

e139

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false true false

--

Go back
309.625, 603.5
27.5885269121813, 33.78186968838527

ssRNA: TLR7

--

e14

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p1

p60

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1036.5, 64.125
31.560000000000002, 23.669999999999995

NS3/4A

--

e140

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p69 p91 p101

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
877.5, 301.5
28.0, 28.0

e141

--

e141

cso30:c:ObjectUnknown

cso30:i:CC_Cytosol

--

p101

--

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
1246.625, 931.5
27.359898350274957, 33.501916347275454

ligand: TLR

--

e142

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p102 p103 p104 p105

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
1139.0, 1047.0
33.0, 33.0

MAPKs{activated}

--

e143

cso30:c:Protein

cso30:i:CC_CellComponent

--

p103

--

true true true true

csml-variable:Double

m146

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
987.5, 1349.0
41.05536332179931, 21.8961937716263

chemokine

--

e144

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p104

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
300.625, 693.5
27.449716713881024, 33.611898016997166

ssRNA: TLR8

--

e15

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p3

p63

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
560.625, 865.5
27.629353441093148, 33.83186135644059

CpG DNA: TLR9

--

e16

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p2

p40 p53

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
128.375, 516.5
28.382075471698105, 30.962264150943398

poly U RNA

--

e17

cso30:c:RnaOther

cso30:i:CC_Extracellular

--

--

p6 p7

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
297.625, 516.5
26.02895350774871, 31.872187968671888

Poly U RNA: TLR7

--

e18

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p6

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
294.625, 732.5
27.319071821363103, 33.45192467922013

Poly U RNA: TLR8

--

e19

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p7

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
186.34245598341363, 199.15652946572055
1088.0717876556314, 1573.801096683933

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
99.375, 774.5
28.340566037735847, 30.91698113207547

siRNA

--

e20

cso30:c:RnaOther

cso30:i:CC_Extracellular

--

--

p8 p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
292.625, 778.5
26.077945342442924, 31.932177970338277

siRNA: TLR8

--

e21

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p9

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
292.625, 469.5
27.359898350274957, 33.501916347275454

siRNA: TLR7

--

e22

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p8

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
63.5, 621.25
45.0, 25.5

imidazoquinoline

--

e23

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10 p11

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
292.625, 420.5
34.35756540576571, 42.070488251958004

imidazoquinoline: TLR7

--

e24

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p10

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
291.625, 820.5
28.739835027495424, 35.191634727545406

imidazoquinoline: TLR8

--

e25

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
124.375, 370.5
30.249999999999996, 32.99999999999999

poly I: C

--

e26

cso30:c:RnaOther

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
311.625, 384.5
27.768163639393432, 34.00183302782869

poly I: C: TLR3

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p12

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
519.875, 398.5
27.98077628922738, 39.04294365938704

dsRNA:TLR3:TRIF: TRAF3

--

e28

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p14

p15

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
917.625, 475.5
29.891143142809536, 36.60139976670555

IRF-7: IRF-7{p}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
208.10389173652624, 220.83423052197318
1044.5489161494058, 1530.44569457143

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
913.625, 694.5
28.519371771371446, 34.921679720046654

IRF-3: IRF-3{p}

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p23

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
951.625, 515.5
36.75, 45.0

IRF-3{p}: IRF-7{p}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p22

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
846.625, 1216.5
29.891143142809536, 36.60139976670555

IRF-7: IRF-7{p}

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p31 p34

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
860.625, 1248.5
36.75, 45.0

IRF-3{p}: IRF-7{p}

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p32 p35

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
872.625, 1301.5
28.519371771371446, 34.921679720046654

IRF-3: IRF-3{p}

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p33 p36

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
621.875, 523.5
32.25, 45.0

dsRNA:TLR3:TRIF: RIP1

--

e35

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p24

p27

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
633.875, 579.5
32.25, 45.0

dsRNA:TLR3:TRIF: TRAF6

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
891.0, 779.0
34.0, 34.0

TAK1{activated}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p28

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
889.0, 885.0
30.0, 30.0

IKK-alpha:IKK-beta:IKK-gamma{activated}

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27 p28 p82 p94 p102

p29

true true true true

csml-variable:Double

m40

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
808.625, 988.5
31.099608398600232, 38.08115314114314

IkappaB: NF-kappaB

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p29

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
248.36254787978476, 258.77020737041477
964.0316038628896, 1454.573740874544

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
800.0, 1124.0
28.0, 28.0

NF-kappaB{nuclear}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p37 p38 p83

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
711.5, 1336.0
36.85121107266436, 19.653979238754324

IFN Type I

--

e41

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31 p32 p33 p43

p46 p70 p79

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
809.5, 1398.0
37.88927335640139, 20.207612456747405

IFN inducible genes

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

p34 p35 p36

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
855.5, 1180.0
37.88927335640139, 20.207612456747405

IL-8

--

e43

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38

p55

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
137.5, 946.25
41.34146341463414, 23.426829268292682

ODN

--

e44

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
339.625, 939.5
29.499208465255787, 36.12147975337444

ODN: TLR9

--

e45

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p39

p43 p44 p45

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
536.875, 899.5
26.023719948614424, 36.31216737015966

CpG DNA: TLR9: MyD88

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
498.875, 920.5
30.750642319691682, 42.90787300422096

CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6: IRF-7

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
445.875, 931.5
32.25, 45.0

CpG DNA: TLR9: MyD88: IRAk-1: IRAK-4: TRAF6

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
591.5, 1268.0
37.88927335640139, 20.207612456747405

cytokine

--

e49

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44

p71 p105

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
298.3464813304762, 362.0614984924051
359.79113648000293, 600.668253275937

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
477.433193972831, 1125.1963439500444
551.4399055586391, 498.1711167236542

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
536.9928113329817, 1137.0022751895078
322.4434457084034, 482.8270371531107

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
484.6214236542286, 1131.8454450972806
537.0634461958442, 484.8729144291828

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
485.64831360871426, 1132.8683837353158
535.0096662868732, 482.8270371531107

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
477.433193972831, 1125.1963439500444
551.4399055586391, 498.1711167236542

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
477.433193972831, 1125.1963439500444
551.4399055586391, 498.1711167236542

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
485.64831360871426, 1132.8683837353158
535.0096662868732, 482.8270371531107

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
879.9740561310924, 1329.7840715572938
34.450935410496186, 31.067159121223522

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
789.6077401363814, 1472.9954808823697
97.55454567610936, 87.97272287111767

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
477.433193972831, 1125.1963439500444
551.4399055586391, 498.1711167236542

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
298.3464813304762, 362.0614984924051
359.79113648000293, 600.668253275937

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
607.4044769742204, 1346.5794718002103
17.463291553213278, 8.375897814979743

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
606.8213282379869, 1321.600562453004
59.77274546391205, 107.1769482455717

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
631.8967238960183, 1391.309146677767
9.3303797797326, 9.294477896634936

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
663.5, 1300.0
37.88927335640139, 20.207612456747405

costimulatory molecule genes

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p45

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
232.625, 1453.5
27.498708548575234, 33.67188801866356

IFN Type I: IFNRs

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p13 p48 p87 p88 p90

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
432.0, 1059.0
28.0, 28.0

IRF-1{activated}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p50 p51 p52

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
639.5, 1240.0
37.110726643598625, 19.792387543252595

IL-12p35

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p52

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
400.625, 940.5
27.31907182136311, 33.45192467922013

CpG-B ODN

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1351.2343049069564, 1021.8668447622025
364.78341947798805, 529.6655250820381

--

e68

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false true false

--

Go back
1372.0269598172017, 1041.9299328334919
323.1981096574975, 489.53934893945944

--

e69

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false true false

--

Go back
245.29307547015412, 341.89375848572246
966.661561991224, 1364.4639342163405

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1351.2343049069564, 1021.8668447622025
364.78341947798805, 529.6655250820381

--

e70

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false true false

--

Go back
1358.5299732965163, 1029.1625131517621
350.19208269886855, 515.0741883029189

--

e71

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false true false

--

Go back
1484.0174094338058, 1423.4260649043383
3.3565299437331357, 3.356529943733139

--

e72

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false true false

--

Go back
1474.9967352100232, 1398.2520903263394
21.502769952040424, 38.70498591367277

--

e73

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false true false

--

Go back
1475.2065183315067, 1407.272764550122
6.282280292794492, 3.0248016224566117

--

e74

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false true false

--

Go back
1573.261257344178, 1401.2074143002988
12.393450108657918, 11.219333782574553

--

e75

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false true false

--

Go back
1431.4057065941201, 1330.0949311768977
192.4654738041142, 174.36411446361228

--

e76

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false true false

--

Go back
1449.8764814313677, 1331.5878101319556
115.99646597791154, 174.36411446361228

--

e77

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false true false

--

Go back
1431.0362910973759, 1329.7255156801525
193.20430479760418, 175.1029454571021

--

e78

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false true false

--

Go back
1428.4503826201608, 1327.3243149513107
198.3761217520333, 179.9053469147864

--

e79

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false true false

--

Go back
273.74657399995164, 272.9752284326282
927.3299549353795, 1341.302032294827

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1428.4503826201608, 1327.3243149513107
198.3761217520333, 179.9053469147864

--

e80

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false true false

--

Go back
1431.4057065941201, 1330.0949311768977
192.4654738041142, 174.36411446361228

--

e81

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false true false

--

Go back
1428.4503826201608, 1327.3243149513107
198.3761217520333, 179.9053469147864

--

e82

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false true false

--

Go back
1428.4503826201608, 1327.3243149513107
198.3761217520333, 179.9053469147864

--

e83

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false true false

--

Go back
1540.7526936306228, 1452.9255838445902
35.094472190769395, 31.76973272006497

--

e84

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false true false

--

Go back
1357.3050861892355, 1032.9446752281422
343.18317676349653, 498.3019726605968

--

e85

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false true false

--

Go back
1356.0270269719133, 1023.9982607068879
357.7388867185135, 506.9067619922847

--

e86

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false true false

--

Go back
1354.7489677545916, 1029.9625370543906
353.5868398169997, 497.3972604590277

--

e87

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false true false

--

Go back
1360.7132441020944, 1041.891089749396
341.61635731379545, 491.7668671523297

--

e88

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false true false

--

Go back
1348.625, 1109.5
30.919971671388105, 37.861189801699716

IL-12: IL-12R

--

e89

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p58

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
210.9559034127449, 319.0566983795339
923.0961850187252, 1323.7111922411586

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1353.375, 1173.5
24.26933216168717, 37.33743409490334

IL-8 receptor

--

e90

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p57

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1352.375, 1229.5
23.25, 45.0

IL-8: IL-8 receptor

--

e91

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p57

p56

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
640.875, 635.5
26.22100385391815, 36.58744723802533

ssRNA: TLR7: MyD88

--

e92

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p60

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
629.875, 675.5
32.25, 45.0

ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7

--

e93

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p61

p62

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
625.875, 727.5
25.684391631492016, 35.83868599743072

ssRNA: TLR7: MyD88: IRAK-1: IRAk-4: TRAF6

--

e94

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p62

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
622.875, 770.5
22.220086254358595, 31.00477151770967

ssRNA: TLR8: MyD88

--

e95

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p63

p64

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
601.875, 800.5
24.997843641035054, 34.880712057258215

ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6: IRF-7

--

e96

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p64

p65

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
589.875, 836.5
24.59538447421545, 34.31914112681226

ssRNA: TLR8: MyD88: IRAK-1: IRAk-4: TRAF6

--

e97

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p65

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
560.375, 273.5
24.13224956063269, 37.12653778558875

RIG-1

--

e98

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p66 p72 p84

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
650.375, 285.5
18.974841043630782, 36.72549879412409

dsRNA: RIG-1

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p66

p69

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
223.0, 608.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e12 MO000042126

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m12*m19940*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

Go back
224.0, 424.0
27.0, 27.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e23 MO000042126

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c32 : 1

m24*m19940*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

Go back
974.0, 206.0
27.0, 27.0

p100

p100

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cell_WithoutCellWall_

--

e130 MO000016907 MO000103999

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c294 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1
stoichiometry:c297 : 1

m132*m1822*m76904*0.1

nodelay

--

true

0

false

PMID: 18086372 Degradation of MDA5 in poliovirus-infected cells occurs in a proteasome- and caspase-dependent manner and correlates with the induction of apoptosis in poliovirus-infected cells.

Go back
1041.0, 237.0
23.0, 23.0

p101

p101

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytoplasm

--

MO000094908 e140

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c299 : 1
stoichiometry:c300 : 1

m68199*m142*0.1

nodelay

--

true

0

false

PMID: 18086372, 16301520, 16177806 Hepatitis C virus (HCV) encodes the protease NS3/4A which targets IPS-1 by cleaving it at position Cys-508, thereby dislocating it from the mitochondrial membrane and thus abrogating further downstream signaling to type I IFN and NFkappaB-dependent target gene expression.

Go back
1015.0, 939.0
25.0, 25.0

p102

p102

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016661 e142

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c303 : 1
stoichiometry:c305 : 1
stoichiometry:c304 : 1

m1637*m144*0.1

nodelay

--

true

0

false

PMID: 18086372 Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.

Go back
1203.0, 1007.0
25.0, 25.0

p103

p103

cso30:i:ME_UnknownActivation

cso30:i:CC_Cell_WithoutCellWall_

--

e142 MO000000077

e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c306 : 1
stoichiometry:c307 : 1
stoichiometry:c308 : 1

m144*m145*0.1

nodelay

--

true

0

false

PMID: 18086372 Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.

Go back
1154.0, 1350.0
27.0, 27.0

p104

p104

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e144 e142

MO000000265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c309 : 1

m147*m144*0.1

nodelay

--

true

0

false

PMID: 18086372 Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.

Go back
309.0, 1317.0
25.0, 25.0

p105

p105

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e49 e142

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c312 : 1
stoichiometry:c313 : 1
stoichiometry:c314 : 1

m64*m144*0.1

nodelay

--

true

0

false

PMID: 18086372 Apart from activating the NFkappaB and MAPK signaling pathways leading to inflammatory cytokine and chemokine production as well as costimulatory molecule expression, the intracellularly localized nucleic acid recognition receptors TLR3, 7, 8 and 9 specifically trigger type I interferon production via MyD88- and TRIF-dependent signaling pathways.

Go back
222.0, 826.0
23.0, 23.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e23 MO000042007

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c33 : 1

m24*m19823*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

Go back
226.0, 374.0
23.0, 23.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000019398 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c34 : 1
stoichiometry:c36 : 1

m3965*m27*0.1

nodelay

--

true

0

false

PMID: 18086372, 11607032 Another ligand for TLR3 is poly(I:C) which is a synthetic dsRNA mimicking viral infection.

Go back
670.0, 1427.0
25.0, 25.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

G010963

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18086372 Up-regulation of TLR3 expression by type I IFN amplifies the response to TLR3 ligands.

Go back
500.0, 353.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 MO000041437

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m1872*m19305*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
606.0, 406.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000016608 e28

MO000041441

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m3902*m1599*m29*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
705.0, 482.0
23.0, 23.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 MO000041441

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c50 : 1
stoichiometry:c47 : 1

m980*m19309*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
697.0, 529.0
26.0, 26.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 MO000041441 e125 e126

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c51 : 1
stoichiometry:c282 : 1
stoichiometry:c285 : 1
stoichiometry:c49 : 1

m977*m19309*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression. PMID: 18086372, 12885884 Two viral proteins of RSV, NS1 and NS2, are involved in blocking the pathway leading to IRF3 phosphorylation, although the activation of NFkappaB and AP-1 is unaffected.

Go back
856.0, 480.0
27.0, 27.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041457

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
914.0, 634.0
27.0, 27.0

p19

p19

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
225.0, 865.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e13 MO000042012

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m13*m19828*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

Go back
869.0, 525.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041457 MO000041456

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m19325*m19324*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression. PMID: 18086372, 16127453 This receptor?adapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes.

Go back
940.0, 1221.0
27.0, 27.0

p21

p21

cso30:i:ME_Translocation

cso30:i:CC_NuclearEnvelopeLumen

--

e29

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
934.0, 1258.0
25.0, 25.0

p22

p22

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression. PMID: 18086372, 16127453 This receptor?adapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes.

Go back
919.0, 1307.0
24.0, 24.0

p23

p23

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e30

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
525.0, 489.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041437 MO000000065

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m19305*m36*0.1

nodelay

--

true

0

false

PMID: 18086372 NFkappaB activation by TLR3 ligands is mediated in two ways ? via association of TRIF with RIP1 or via interaction of TRIF with TRAF6, which in turn activates TAK1.

Go back
561.0, 541.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000041437 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m19305*m183*0.1

nodelay

--

true

0

false

PMID: 18086372 NFkappaB activation by TLR3 ligands is mediated in two ways ? via association of TRIF with RIP1 or via interaction of TRIF with TRAF6, which in turn activates TAK1.

Go back
807.0, 731.0
25.0, 25.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e36 MO000016574

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m38*m1573*0.1

nodelay

--

true

0

false

PMID: 18086372 NFkappaB activation by TLR3 ligands is mediated in two ways ? via association of TRIF with RIP1 or via interaction of TRIF with TRAF6, which in turn activates TAK1.

Go back
803.0, 795.0
25.0, 25.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 MO000016661

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m37*m1637*0.1

nodelay

--

true

0

false

PMID: 18086372, 15064760, 14530355 Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus.

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819.0, 887.0
25.0, 25.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e37 MO000016661

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m39*m1637*0.1

nodelay

--

true

0

false

PMID: 18086372, 15064760, 14530355 Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus.

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885.0, 973.0
29.0, 29.0

p29

p29

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e38 e39

MO000019479 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c83 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m40*m41*0.1

nodelay

--

true

0

false

PMID: 18086372, 15064760, 14530355 Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus. PMID: 18086372 Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta. PMID: 18086372 Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.

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226.0, 695.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e12 MO000042007

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m12*m19823*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

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852.0, 1124.0
27.0, 27.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_NuclearOuterMembrane

--

MO000000058

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18086372, 15064760, 14530355 Both RIP1 and TAK1 mediate activation of canonical IKKs (IKKalpha, IKKbeta) resulting in IkappaB degradation and NFkappaB translocation to the nucleus. PMID: 18086372 Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta.

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777.0, 1222.0
25.0, 25.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c89 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

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777.0, 1257.0
27.0, 27.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c90 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression. PMID: 18086372, 16127453 This receptor?adapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes.

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777.0, 1305.0
28.0, 28.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c91 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

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778.0, 1350.0
25.0, 25.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c95 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

Go back
815.0, 1351.0
23.0, 23.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c96 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

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850.0, 1350.0
25.0, 25.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c97 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18086372, 12692549, 12702806, 12855817 Interaction of TRIF with TRAF3 allows complex formation with the non-canonical IKKs-TBK1 and IKK-epsilon leading to the activation of IRF3 and IRF7, which form homo- or heterodimers upon phosphorylation and are then translocated to the nucleus to induce type I IFN and IFN inducible gene expression.

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750.0, 1126.0
24.0, 24.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e40

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18086372, 17339430 Interestingly, human lung epithelial cells express proinflammatory cytokines including IL-6 and IL-8 upon infection with influenza A virus in a TLR3-dependent manner , suggesting that TLR3-mediated inflammatory responses may also contribute to influenza virus-induced lung pathology in humans.

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802.0, 1178.0
23.0, 23.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e40

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18086372, 17339430 Interestingly, human lung epithelial cells express proinflammatory cytokines including IL-6 and IL-8 upon infection with influenza A virus in a TLR3-dependent manner , suggesting that TLR3-mediated inflammatory responses may also contribute to influenza virus-induced lung pathology in humans.

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225.0, 945.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042012 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m19828*m46*0.1

nodelay

--

true

0

false

PMID: 18086372 TLR9 has been described to recognize bacterial DNA or synthetic oligodesoxyribonucleotides (ODN) containing specific unmethylated CpG sequence motifs. These can also be found in the genome of DNA viruses.

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347.0, 271.0
26.0, 26.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398 e123

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c281 : 1
stoichiometry:c12 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18086372, 15558055, 16424225 TLR3 binds double-stranded (ds) RNA which is found in dsRNA viruses, such as reovirus, or is generated during replication of single-stranded (ss) RNA viruses such as West Nile virus or respiratory syncytial virus or as a by-product of symmetrical transcription of viral DNA, for example from herpes viruses. PMID: 18086372, 15298172, 10933707 By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.

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638.0, 850.0
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e16

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m1572*m16*0.1

nodelay

--

true

0

false

PMID: 18086372, 15492225, 15361868 Upon ligand binding the TIR domain of TLR9 recruits MyD88 which forms a supramolecular complex with TRAF6, IRAK1, IRAK4 and IRF7.

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633.0, 909.0
25.0, 25.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e46 MO000000213 MO000039077 MO000007702

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m183*m48*m184*m17258*m980*0.1

nodelay

--

true

0

false

PMID: 18086372, 15492225, 15361868 Upon ligand binding the TIR domain of TLR9 recruits MyD88 which forms a supramolecular complex with TRAF6, IRAK1, IRAK4 and IRF7.

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758.0, 942.0
23.0, 23.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e47

MO000041457 e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c116 : 1
stoichiometry:c115 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18086372, 15492225, 15361868 Upon ligand binding the TIR domain of TLR9 recruits MyD88 which forms a supramolecular complex with TRAF6, IRAK1, IRAK4 and IRF7.

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538.0, 1334.0
23.0, 23.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c117 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18086372 CpG ODN class A, B and C have been designed to trigger primarily type I IFN response (A) or costimulatory molecule expression and inflammatory cytokine production (B) or both (C) in pDCs. PMID: 18086372, 16864658 Induction of type I IFNs by TLR9 ligands in pDCs depends on retention of the ligand?receptor complex within early endosomes at a pH value between 6.2 and 5.5.

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533.0, 1265.0
25.0, 25.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c119 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18086372 CpG ODN class A, B and C have been designed to trigger primarily type I IFN response (A) or costimulatory molecule expression and inflammatory cytokine production (B) or both (C) in pDCs. PMID: 18086372, 16864658 Delivery of TLR9 ligands to late endosome with lower pH values (<4.5) impairs the induction of type I IFNs and promotes inflammatory cytokine and costimulatory molecule expression in pDCs.

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538.0, 1298.0
23.0, 23.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e45

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c120 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18086372 CpG ODN class A, B and C have been designed to trigger primarily type I IFN response (A) or costimulatory molecule expression and inflammatory cytokine production (B) or both (C) in pDCs. PMID: 18086372, 16864658 Delivery of TLR9 ligands to late endosome with lower pH values (<4.5) impairs the induction of type I IFNs and promotes inflammatory cytokine and costimulatory molecule expression in pDCs.

Go back
423.0, 1379.0
25.0, 25.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e41

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c123 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 18086372 During the second phase secreted type I IFNs signal via type I IFN receptor in an autocrine and paracrine manner.

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154.0, 1458.0
24.0, 24.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016658 MO000016834

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m1634*m1771*0.1

nodelay

--

true

0

false

PMID: 18086372 During the second phase secreted type I IFNs signal via type I IFN receptor in an autocrine and paracrine manner.

Go back
466.0, 1414.0
27.0, 27.0

p48

p48

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010713 e64

MO000007702

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m93631*m66*0.1

nodelay

--

true

0

false

PMID: 18086372 Downstream signaling of the type I IFN receptor induces a strong up-regulation of IRF7 production leading to full expression of type I IFN genes (positive feedback loop).

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404.0, 1011.0
27.0, 27.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007685 e67

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c131 : 1
stoichiometry:c133 : 1

m970*m70*0.1

nodelay

--

true

0

false

PMID: 18086372, 17018642, 17273999 In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1¡Ý/¡Ý mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.

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445.0, 301.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c15 : 1
stoichiometry:c14 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18086372 TRIF is recruited to the cytoplasmatic TIR domain of TLR3 and interacts with a set of different signaling molecules and kinases which in turn initiate activation of NFkappaB or IRF3 and IRF7 leading to type I interferon induction.

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562.0, 1170.0
23.0, 23.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c134 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18086372, 17018642, 17273999 In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1¡Ý/¡Ý mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.

Go back
542.0, 1206.0
23.0, 23.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c135 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18086372, 17018642, 17273999 In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1¡Ý/¡Ý mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.

Go back
533.0, 1237.0
25.0, 25.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c136 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18086372, 17018642, 17273999 In myeloid DCs IRF1 plays a crucial role in the downstream signaling of TLR9. IRF1¡Ý/¡Ý mice show an impaired induction of IFN-beta, iNOS and IL-12p35 upon stimulation with TLR9 ligand CpG-B, whereas type I interferon response of pDCs is not affected by lack of IRF1.

Go back
613.0, 1049.0
25.0, 25.0

p53

p53

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e16

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c140 : 1

m93589*m16*0.1

nodelay

--

true

0

false

PMID: 18086372 In the very early phase of systemic MCMV infection pDCs and conventional DCs release the first wave of type I interferons and inflammatory cytokines including IL-12.

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1303.0, 1117.0
25.0, 25.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017265 MO000033676

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m2121*m12340*0.1

nodelay

--

true

0

false

PMID: 18086372, 8557990 Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.

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1031.0, 1183.0
25.0, 25.0

p55

p55

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e43

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c146 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18086372, 8557990 Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.

Go back
1426.0, 1294.0
27.0, 27.0

p56

p56

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e91 G010453

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m94*m93423*0.1

nodelay

--

true

0

false

PMID: 18086372, 8557990 Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.

Go back
1311.0, 1236.0
25.0, 25.0

p57

p57

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017264 e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m2120*m93*0.1

nodelay

--

true

0

false

PMID: 18086372, 8557990 Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.

Go back
1466.0, 1282.0
27.0, 27.0

p58

p58

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e89 G010453

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c156 : 1

m92*m93423*0.1

nodelay

--

true

0

false

PMID: 18086372, 8557990 Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.

Go back
1300.0, 1337.0
29.0, 29.0

p59

p59

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

MO000016665

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 18086372, 8557990 Control of viral replication and clearance of the virus from infected organs during the first week of MCMV infection relies mostly on NK cells, which produce IFN-gamma (mediated by IL-12 and IL-18) and kill infected cells.

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222.0, 519.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e17 MO000042126

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m18*m19940*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

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733.0, 641.0
25.0, 25.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e14 MO000016573

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m14*m1572*0.1

nodelay

--

true

0

false

PMID: 18086372 The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.

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678.0, 742.0
23.0, 23.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 MO000039077 MO000000212 MO000007702

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m184*m17258*m183*m980*0.1

nodelay

--

true

0

false

PMID: 18086372 The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.

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777.0, 685.0
25.0, 25.0

p62

p62

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e93

MO000041457 e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 18086372 The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.

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513.0, 773.0
25.0, 25.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e15 MO000016573

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m15*m1572*0.1

nodelay

--

true

0

false

PMID: 18086372 The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.

Go back
657.0, 809.0
25.0, 25.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e95 MO000000213 MO000039077 MO000000212 MO000007702

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m98*m184*m17258*m183*m980*0.1

nodelay

--

true

0

false

PMID: 18086372 The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.

Go back
716.0, 756.0
27.0, 27.0

p65

p65

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e96

e97 MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m99*0.1

nodelay

--

true

0

false

PMID: 18086372 The MyD88-dependent signal transduction pathway downstream of TLR7 and 8 is very similar to TLR9-mediated signaling.

Go back
592.0, 180.0
23.0, 23.0

p66

p66

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 e98 e105 e123

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c202 : 1
stoichiometry:c278 : 1
stoichiometry:c185 : 1

m119368*m101*0.1

nodelay

--

true

0

false

PMID: 18086372 In addition to the TLRs, a new family of viral pattern recognition receptors consisting of RNA helicases retinoic acid inducible gene I (RIG-I), melanoma differentiation antigen 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) ? was discovered and characterized in the last 3 years. PMID: 18086372, 17190814 Saito et al. also identified an analogous RD within the C terminus of LGP2 suggesting that LGP2 might inhibit RIG-I through their RD interactions. PMID: 18086372, 15298172, 10933707 By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.

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655.0, 179.0
25.0, 25.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

MO000022224 MO000103999 e123 e129

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c279 : 1
stoichiometry:c293 : 1
stoichiometry:c186 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 18086372 In addition to the TLRs, a new family of viral pattern recognition receptors consisting of RNA helicases retinoic acid inducible gene I (RIG-I), melanoma differentiation antigen 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) ? was discovered and characterized in the last 3 years. PMID: 18086372, 15298172, 10933707 By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3. PMID: 18086372, 15563593, 17049367 The V proteins of this diverse group of viruses bind MDA5 via their highly conserved cysteine-rich C-terminal domain.This suggests that paramyxoviruses use this interaction to reduce the amount of IFN released by infected cells.

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412.0, 180.0
23.0, 23.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 e101 e123

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c280 : 1
stoichiometry:c189 : 1

m119368*m104*0.1

nodelay

--

true

0

false

PMID: 18086372 In addition to the TLRs, a new family of viral pattern recognition receptors consisting of RNA helicases retinoic acid inducible gene I (RIG-I), melanoma differentiation antigen 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) ? was discovered and characterized in the last 3 years. PMID: 18086372, 16116171 LGP2 is a close relative of RIG-I, which lacks the CARDs, but is capable of binding dsRNA. PMID: 18086372, 15298172, 10933707 By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.

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947.0, 375.0
25.0, 25.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e99 e140

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c196 : 1
stoichiometry:c301 : 1
stoichiometry:c198 : 1

m68199*m102*0.1

nodelay

--

true

0

false

PMID: 18086372 The binding of dsRNA to the helicase domain of RIG-I likely induces a conformational change that exposes the N-terminal CARD domains to recruit its signaling adaptor IPS-1. PMID: 18086372, 16301520, 16177806 Hepatitis C virus (HCV) encodes the protease NS3/4A which targets IPS-1 by cleaving it at position Cys-508, thereby dislocating it from the mitochondrial membrane and thus abrogating further downstream signaling to type I IFN and NFkappaB-dependent target gene expression.

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226.0, 735.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e17 MO000042007

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m18*m19823*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

Go back
457.0, 1358.0
23.0, 23.0

p70

p70

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e41 e102

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c192 : 1
stoichiometry:c191 : 1

m43*m105*0.1

nodelay

--

true

0

false

PMID: 18086372 These molecules, which are localized in the cytosol, bind specific RNA molecules derived from the genome of different RNA viruses and, with the exception of LGP2 which does not signal itself, trigger a signaling cascade leading to the production of type I IFNs and of proinflammatory cytokines in response to viral infection.

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307.0, 1195.0
30.0, 30.0

p71

p71

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e49 e102

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c195 : 1
stoichiometry:c194 : 1

m64*m105*0.1

nodelay

--

true

0

false

PMID: 18086372 These molecules, which are localized in the cytosol, bind specific RNA molecules derived from the genome of different RNA viruses and, with the exception of LGP2 which does not signal itself, trigger a signaling cascade leading to the production of type I IFNs and of proinflammatory cytokines in response to viral infection.

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559.0, 343.0
26.0, 26.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e98 e101

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m101*m104*0.1

nodelay

--

true

0

false

PMID: 18086372, 17190814 Saito et al. also identified an analogous RD within the C terminus of LGP2 suggesting that LGP2 might inhibit RIG-I through their RD interactions.

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1068.0, 477.0
25.0, 25.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e107 MO000007694

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c203 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m110*m977*0.1

nodelay

--

true

0

false

PMID: 18086372, 16153868 Coimmunoprecipitation experiments suggest that IPS-1 interacts with TBK1 and recruits endogenous IRF3 in a virus-inducible manner.

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1195.0, 415.0
25.0, 25.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e103 MO000016963

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1
stoichiometry:c208 : 1

m106*m1872*0.1

nodelay

--

true

0

false

PMID: 18086372, 16858409 Recently, TRAF3 was shown to be critically involved in IPS-1-mediated IFN-alpha production and antiviral responses through a direct interaction between the TRAF domain of TRAF3 and a TRAF interaction motif within IPS-1.

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1125.0, 378.0
23.0, 23.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e103 e104 e124

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c211 : 1
stoichiometry:c277 : 1
stoichiometry:c212 : 1

m106*m107*0.1

nodelay

--

true

0

false

PMID: 18086372, 16153868 Coimmunoprecipitation experiments suggest that IPS-1 interacts with TBK1 and recruits endogenous IRF3 in a virus-inducible manner. PMID: 18086372, 17079289 Furthermore, it was observed that NS1 colocalizes with RIG-I (Mibayashi et al., 2007), suggesting that NS1 forms a complex with RIG-I and IPS-1 during viral infection, resulting in inhibition of further downstream signaling.

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1072.0, 517.0
25.0, 25.0

p76

p76

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e108 e125 e126 e127

MO000041456 e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c284 : 1
stoichiometry:c287 : 1
stoichiometry:c288 : 1
stoichiometry:c213 : 1
stoichiometry:c214 : 1

m111*0.1

nodelay

--

true

0

false

PMID: 18086372, 16127453 This receptor?adapter interaction results in the activation of the noncanonical kinases TBK1/IKK-epsilon, which in turn induces dimerization of phosphorylated IRF3 and IRF7 and translocation to the nucleus where they activate the transcription of type I IFN genes. PMID: 18086372, 12885884 Two viral proteins of RSV, NS1 and NS2, are involved in blocking the pathway leading to IRF3 phosphorylation, although the activation of NFkappaB and AP-1 is unaffected. PMID: 18086372, 15919920 IRF3 phosphorylation by TBK1 was identified as target of the Rabies virus phosphoprotein P.

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915.0, 1623.0
25.0, 25.0

p77

p77

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G016992 e106

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c215 : 1

m98717*m109*0.1

nodelay

--

true

0

false

PMID: 18086372, 16858409 Recently, TRAF3 was shown to be critically involved in IPS-1-mediated IFN-alpha production and antiviral responses through a direct interaction between the TRAF domain of TRAF3 and a TRAF interaction motif within IPS-1.

Go back
1107.0, 659.0
25.0, 25.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 e103 MO000016899

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m36*m106*m1814*0.1

nodelay

--

true

0

false

PMID: 18086372, 15549108 RIP1 and FADD are additional molecules that have been reported to be required for type I IFN production in response to dsRNA.

Go back
387.0, 1391.0
25.0, 25.0

p79

p79

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e41 e109

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c224 : 1
stoichiometry:c223 : 1

m43*m112*0.1

nodelay

--

true

0

false

PMID: 18086372, 15549108 RIP1 and FADD are additional molecules that have been reported to be required for type I IFN production in response to dsRNA.

Go back
224.0, 472.0
27.0, 27.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e20 MO000042126

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m21*m19940*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

Go back
1184.0, 739.0
27.0, 27.0

p80

p80

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e104 e106 MO000019326

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c227 : 1
stoichiometry:c228 : 1
stoichiometry:c226 : 1

m107*m109*m3897*0.1

nodelay

--

true

0

false

PMID: 18086372, 17327220 There is evidence that the TBK1/IKK-epsilon adaptor protein TANK plays a role in IPS-1-TRAF3-mediated activation of TBK1/IKK-epsilon.

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1184.0, 868.0
23.0, 23.0

p81

p81

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e103

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m183*m106*0.1

nodelay

--

true

0

false

PMID: 18086372, 16125763, 16153868 IPS-1 binds to TRAF6 upon overexpression in mammalian cells and in a yeast-two hybrid screen reported that endogenous IPS-1 also interacts with TRAF6.

Go back
1007.0, 887.0
25.0, 25.0

p82

p82

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016661 e111

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c234 : 1
stoichiometry:c233 : 1

m1637*m114*0.1

nodelay

--

true

0

false

PMID: 18086372 Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta.

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749.0, 1170.0
23.0, 23.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e40

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c235 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18086372 Another branch of IPS-1 signaling leads to the activation of the IKK complex resulting in activation of NFkappaB that controls the expression of genes encoding inflammatory responses, but also expression of IFN-beta.

Go back
523.0, 223.0
25.0, 25.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e98 e112

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c238 : 1
stoichiometry:c239 : 1

m101*m115*0.1

nodelay

--

true

0

false

PMID: 18086372, 17038590 Taken together, the results of Hornung et al.(2006) show that RIG-I directly recognizes 5¡ì-triphosphate single stranded or double stranded RNA independently of viral replication.

Go back
757.0, 153.0
29.0, 29.0

p85

p85

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cell_WithoutCellWall_

--

MO000103999 MO000016907

e115 e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c243 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m76904*m1822*0.1

nodelay

--

true

0

false

PMID: 18086372, 12015121 It was reported in a previous publication, that MDA5, which was then called Helicard, is cleaved by caspases upon induction of apoptosis, thereby separating the CARD domains from the C-terminal helicase domain, which localizes to the nucleus where it is involved in DNA degradation and nuclear remodelling during apoptotic cell death.

Go back
1122.0, 1426.0
27.0, 27.0

p86

p86

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e115

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 18086372, 12015121 It was reported in a previous publication, that MDA5, which was then called Helicard, is cleaved by caspases upon induction of apoptosis, thereby separating the CARD domains from the C-terminal helicase domain, which localizes to the nucleus where it is involved in DNA degradation and nuclear remodelling during apoptotic cell death.

Go back
627.0, 1467.0
25.0, 25.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c247 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18086372 MDA5 is ubiquitously expressed in low abundance and similarly to RIG-I and LGP2 its expression is induced by type I IFN.

Go back
673.0, 1501.0
21.0, 21.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c248 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18086372 MDA5 is ubiquitously expressed in low abundance and similarly to RIG-I and LGP2 its expression is induced by type I IFN.

Go back
937.0, 1369.0
30.0, 30.0

p89

p89

cso30:i:ME_DNAFragmentationDuringApoptosis

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e116

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1

m119*0.1

nodelay

--

true

0

false

PMID: 18086372, 12015121 It was reported in a previous publication, that MDA5, which was then called Helicard, is cleaved by caspases upon induction of apoptosis, thereby separating the CARD domains from the C-terminal helicase domain, which localizes to the nucleus where it is involved in DNA degradation and nuclear remodelling during apoptotic cell death.

Go back
223.0, 779.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e20 MO000042007

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m21*m19823*0.1

nodelay

--

true

0

false

PMID: 18086372, 14976262, 11812998, 14976261 GU-rich ssRNA sequences of viral or host origin, poly-U RNA and specific siRNA sequences are ligands for both receptors, whereas synthetic imidazoquinoline derivatives have been designed to specifically activate TLR7 or TLR8 or both receptors.

Go back
797.0, 1505.0
21.0, 21.0

p90

p90

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c249 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18086372 MDA5 is ubiquitously expressed in low abundance and similarly to RIG-I and LGP2 its expression is induced by type I IFN.

Go back
699.0, 331.0
25.0, 25.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e100 MO000094908 e140

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c254 : 1
stoichiometry:c302 : 1
stoichiometry:c255 : 1

m103*m68199*0.1

nodelay

--

true

0

false

PMID: 18086372 Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively. PMID: 18086372, 16301520, 16177806 Hepatitis C virus (HCV) encodes the protease NS3/4A which targets IPS-1 by cleaving it at position Cys-508, thereby dislocating it from the mitochondrial membrane and thus abrogating further downstream signaling to type I IFN and NFkappaB-dependent target gene expression.

Go back
660.0, 380.0
23.0, 23.0

p92

p92

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e120 MO000019331 MO000016608

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c257 : 1
stoichiometry:c258 : 1
stoichiometry:c259 : 1

m123*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 18086372 Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.

Go back
830.0, 426.0
24.0, 24.0

p93

p93

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e121

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c267 : 1
stoichiometry:c261 : 1

m980*m124*0.1

nodelay

--

true

0

false

PMID: 18086372 Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.

Go back
946.0, 846.0
27.0, 27.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016661 e120

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c264 : 1
stoichiometry:c263 : 1

m1637*m123*0.1

nodelay

--

true

0

false

PMID: 18086372 Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively.

Go back
736.0, 564.0
23.0, 23.0

p95

p95

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e121 e125 e126 e127

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c268 : 1
stoichiometry:c283 : 1
stoichiometry:c286 : 1
stoichiometry:c289 : 1
stoichiometry:c266 : 1

m977*m124*0.1

nodelay

--

true

0

false

PMID: 18086372 Like RIG-I, MDA5 interacts with the adapter protein IPS-1 upon ligand binding leading to activation of protein kinases that subsequently activate transcription factors IRF3, IRF7 and NFkappaB, respectively. PMID: 18086372, 12885884 Two viral proteins of RSV, NS1 and NS2, are involved in blocking the pathway leading to IRF3 phosphorylation, although the activation of NFkappaB and AP-1 is unaffected. PMID: 18086372, 15919920 IRF3 phosphorylation by TBK1 was identified as target of the Rabies virus phosphoprotein P.

Go back
601.0, 1121.0
23.0, 23.0

p96

p96

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e120

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c269 : 1

m123*0.1

nodelay

--

true

0

false

PMID: 18086372 In addition, it was shown that MDA5 might also play a role in the measles virus (MV) induced activation of IFN-beta mRNA synthesis since A549 cells transfected with MDA5 showed a strong activation of the IFN-beta promoter upon infection with MV.

Go back
668.0, 48.0
23.0, 23.0

p97

p97

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e122 MO000022224

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c271 : 1
stoichiometry:c272 : 1
stoichiometry:c273 : 1

m69*m119368*0.1

nodelay

--

true

0

false

PMID: 18086372, 15298172, 10933707 By binding to dsRNA NS1 disguises the viral dsRNA pattern from the cytoplasmic receptors and inhibits IFN-alpha/INF-beta induction via IRF3.

Go back
1007.0, 323.0
25.0, 25.0

p98

p98

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e122 e103

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c274 : 1
stoichiometry:c275 : 1
stoichiometry:c276 : 1

m69*m106*0.1

nodelay

--

true

0

false

PMID: 18086372, 17079289 Furthermore, it was observed that NS1 colocalizes with RIG-I (Mibayashi et al., 2007), suggesting that NS1 forms a complex with RIG-I and IPS-1 during viral infection, resulting in inhibition of further downstream signaling.

Go back
919.0, 127.0
25.0, 25.0

p99

p99

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

MO000103999 e128

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c291 : 1
stoichiometry:c292 : 1

m76904*m130*0.1

nodelay

--

true

0

false

PMID: 18086372, 15563593, 17049367 The V proteins of this diverse group of viruses bind MDA5 via their highly conserved cysteine-rich C-terminal domain.This suggests that paramyxoviruses use this interaction to reduce the amount of IFN released by infected cells.

Go back
190.0, 631.1464137287468

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.0142092173888, 71.82004659761833

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
727.5110105270928, 1142.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
825.0, 1190.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.2469504755442, 909.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
179.0, 958.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 958.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
669.0, 862.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 867.0130708141196

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
569.9800481275978, 869.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
663.293316448824, 627.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
563.0, 918.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.0, 304.9971570716942

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.8995250553337, 908.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.9684655104985, 941.9999994804795

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.9998928926076, 453.59977393361623

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.9051906147945, 924.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 943.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 954.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.5652334876436, 505.19818528654406

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 1346.0

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 976.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.0, 1278.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.0, 297.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 1310.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 976.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.0, 976.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
186.99328982787767, 1393.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
455.9999880846171, 1356.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
165.0, 1419.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
184.37157053079787, 1483.8376739215316

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
178.0, 1470.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.0, 1428.0

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
260.0, 1431.4142619879872

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
419.0, 332.2300312726663

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
480.0, 417.83130514088464

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 974.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
439.0, 1025.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 1038.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
585.0, 1183.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 1218.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.0, 1250.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
449.0, 1087.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.0, 1087.0

c138

c138

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
445.9305578024751, 1087.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
458.0, 326.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.0, 1062.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.734068956465, 1081.0750780227759

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
575.0, 899.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1316.0, 1082.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1329.7157525604755, 1080.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1328.0, 1128.3805211953236

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1056.0, 1196.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1324.0, 1210.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1337.761820405006, 1209.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1336.0, 1250.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 314.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 1191.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1376.0, 1261.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1377.0, 1147.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1480.2889679298512, 1316.9947793925485

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1449.2011327551918, 1328.3316266328584

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1420.7455923043988, 1321.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1425.2859030265015, 1307.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1336.9954075771186, 1353.271030765326

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.0, 620.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.0, 674.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.0, 532.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.0, 654.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
691.4717643604923, 772.9860777850062

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.5048636347066, 772.9984649267276

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.9667753853427, 627.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
708.9999963584577, 455.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.9656235549245, 724.272366595694

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
662.0, 698.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
791.0, 518.9742299563793

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.6369261387798, 702.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
321.0, 727.0

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.92024951409442, 543.0137447181747

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.973481530565, 787.6508396743737

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 786.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0, 798.0

c172

c172

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.3888343054963, 841.6350160877947

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.0041528017706, 841.9999989221398

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.3034906119286, 620.0

c175

c175

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
689.9999989157407, 455.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.9822812628529, 819.5321520841902

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 779.0710285511013

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.6865033110918, 779.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
247.0, 532.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 499.6472802273726

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 87.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 76.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 210.61063226800843

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.3409919128368, 205.87768608679755

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.0, 203.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.0, 204.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.81587807234064, 74.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
439.2850231591362, 209.00570813538204

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
353.67215228157215, 200.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
142.8844808236443, 547.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
487.9674265447431, 1348.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
186.95072048076986, 1371.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
62.39138140691114, 139.68744807542123

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
344.7873373466686, 1215.8323146698044

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
322.0, 1225.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
46.14572165960692, 120.03105544615278

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.0, 304.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.0, 388.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 388.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 311.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.89547372126216, 584.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.4012660701202, 676.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 276.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.0, 356.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.7789159216526, 206.92342834610193

c202

c202

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1098.9987028429207, 450.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.0, 494.5621011218619

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.0, 490.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1094.0, 392.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
512.5353228671551, 98.12577578422002

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1115.7061372901007, 440.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1103.7942826023123, 499.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
251.0, 748.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1094.0, 389.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1137.0, 337.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.0, 401.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.5823503013634, 534.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1093.0, 464.82911424269304

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.0, 1636.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 1494.0

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
947.9999956240142, 651.0

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.0, 515.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.0, 371.81730318057953

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
113.87176223910241, 485.6536066829897

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.3692975529848, 685.8406661402685

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.0, 684.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.99999971550346, 1356.0

c222

c222

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
187.0, 1404.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.75696139196725, 759.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1153.0, 318.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.6753833509902, 766.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1108.0, 628.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1163.0, 767.8483457221029

c228

c228

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
723.0, 620.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
254.0335858293437, 505.2179589656599

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1094.0, 342.12346354714987

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1171.427813527082, 885.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 865.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
927.0, 900.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1040.0, 900.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.9986028641179, 1182.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.1818100362019, 1150.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
548.1927794053147, 254.81326653363635

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 63.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 236.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 486.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.0, 188.14577023677901

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.0, 182.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 182.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
792.2018798841383, 184.0533836092979

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
867.0, 279.55339901950754

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
977.0, 1440.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.0, 1406.9955592558333

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
652.0, 1480.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
694.0, 1512.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
809.0, 1489.9699247055655

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.0, 790.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 1470.0

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
260.0, 1471.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
257.0, 1487.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
712.0, 303.0

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
731.5039559906329, 350.77320112697305

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.0, 344.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.3033886328969, 349.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
672.1817712428264, 410.99793468435956

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.465257030206, 408.84217130815114

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 392.0

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.2694723596099, 676.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
800.0, 443.2987830845308

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.2625061574892, 450.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 860.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
925.5424513544061, 870.0

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.0, 361.0

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.3730830011045, 547.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
759.0, 580.0

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.0, 400.0

c267

c267

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.677298100499, 411.0

c268

c268

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
616.0, 1144.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 792.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
27.824041924199378, 31.54290043002652

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
698.5464991266991, 37.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 63.289055191217216

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 60.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 32.0

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1037.9987028429207, 351.29297309669477

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.0, 336.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.0, 350.0

c277

c277

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
618.5685511630787, 67.0

c278

c278

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
683.3221759676763, 70.0

c279

c279

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
85.96804090395956, 438.00560105633525

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
438.8300327568163, 64.0

c280

c280

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
376.65524619448104, 66.0

c281

c281

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
726.9829626962238, 486.0

c282

c282

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
762.9522504834683, 487.0

c283

c283

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1100.9354796403995, 488.0

c284

c284

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
726.9997204000273, 535.0

c285

c285

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
762.9901958346077, 536.0

c286

c286

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1100.9989483149195, 530.0917189980486

c287

c287

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1100.9130473857995, 533.8294939158837

c288

c288

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
762.9997662732264, 576.0432407164673

c289

c289

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
85.64946390754218, 647.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
733.0, 149.16088890274216

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 76.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 152.0

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.858680896224, 196.05384142123765

c293

c293

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
988.0, 120.0

c294

c294

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
872.0, 222.93472998053917

c295

c295

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
733.0, 221.33166481106196

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0, 220.0

c297

c297

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0, 261.24945781176467

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1052.0, 88.0

c299

c299

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
246.0, 620.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.75479274371904, 458.06410160259003

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.3894644729725, 254.0

c300

c300

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.135898311074, 88.0

c301

c301

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
727.1400445830265, 88.0

c302

c302

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
915.0, 871.0

c303

c303

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.3571183876564, 909.1421026447282

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.9985068010415, 948.0

c305

c305

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1228.2108369169305, 965.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1172.0, 1020.0

c307

c307

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.4247842258703, 1029.0

c308

c308

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1168.0, 1377.0

c309

c309

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.4226184182167, 676.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1029.0, 1361.0

c310

c310

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1172.724699945002, 965.0

c311

c311

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
341.8704707317975, 1281.0

c312

c312

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
319.9093349561098, 965.0

c313

c313

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
323.0, 1294.9955592558333

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 439.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
245.0, 838.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
155.0, 386.1126648820378

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 386.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
249.0, 388.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.0, 1441.5450718642544

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.0, 1440.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.0, 327.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 670.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 366.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
518.0, 378.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.2679814327163, 431.9711576880164

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.6703849016671, 423.272706637531

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.6568542494924, 429.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.0, 418.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.8743430752777, 463.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 494.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.9981507165726, 540.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.0, 549.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.8715757936685, 670.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.0, 462.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
595.0, 469.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
823.0, 494.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0, 494.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 619.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.0, 661.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
823.0, 504.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
850.0, 556.9556524591421

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.0, 538.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 493.50090507977177

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
251.0, 708.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
885.0, 1235.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
966.9060484329599, 561.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.0, 1271.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.0, 729.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.0, 1319.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
461.0, 383.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.9822812628529, 503.5321520841902

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 507.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.79274267472897, 383.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.3354802027309, 562.1922923104477

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
177.0, 878.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 562.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
666.0, 615.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 744.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 751.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
654.0, 552.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
846.7157525604754, 813.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
834.7639112242477, 819.2719439311038

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 820.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
850.9041157547755, 869.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 900.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.7425800543062, 883.0130708141196

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.2756982067182, 915.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
914.0, 988.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 1002.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.0, 994.0613012044827

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
886.9874151644264, 1054.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
836.0, 1138.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
810.0, 1235.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 1271.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.0, 1319.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.7975155950143, 1247.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
250.0, 878.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.0266968567009, 1284.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.3000745961197, 1325.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.8912602963194, 1253.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
837.9162780536611, 1294.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
873.9691115068547, 1336.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
801.0, 1375.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.0, 1374.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
840.9304660932648, 1375.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 1138.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
814.0, 1152.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back