1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18160296.csml convertedTime:2009.07.01.11:12

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title C-type lectin receptors in antifungal immunity.
Authors Willment JA, Brown GD.
Affiliation Institute of Infectious Disease and Molecular Medicine, Division of Immunology,CLS, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Abstract Fungal infections represent a significant health burden, especially inimmunocompromised individuals, yet many of the underlying immunologicalmechanisms involved in the recognition and control of these pathogens areunclear. The identification of the Toll-like receptors (TLRs) has shed newinsights on innate microbial recognition and the initiation of immune responses;however, recent evidence indicates that the 'non-TLR' receptors also have asignificant role in these processes, particularly in antifungal immunity. Ofinterest are members of the C-type lectin-receptor family, including the mannosereceptor, dendritic cell-specific intercellular adhesion molecule-3(ICAM-3)-grabbing non-integrin (DC-SIGN), Dectin-1, Dectin-2 and the collectins.Here, we review the roles of each of these receptors, describing how theycontribute to fungal recognition, uptake and killing and also participate in theinduction and/or modulation of the host immune response.
PMID 18160296
Model Abstract

Entity

G010220:GM-CSF G010229:IL-2 G010262:IL-6 G010329:TNF-alpha G010389:IL-1beta G010657:IL-12 p40 G011345:IL10 MO000000058:NF-kappaB MO000000099:GM-CSF MO000000289:TNF-alpha MO000007384:IL-6 MO000007694:IRF-3 MO000008301:Syk MO000016573:MyD88 MO000016597:IL-1beta MO000016723:PLA2 MO000017061:IL-2 MO000017264:IL-8 MO000017265:IL-12 MO000017520:calreticulin MO000018132:CD14 MO000019387:cytokines MO000019395:TLR: TLR MO000019699:alpha2 beta1 MO000041125:TRIF MO000042415:DC-SIGN MO000044196:CARD9 {activated} MO000062069:MBL MO000069544:CoxII MO000070528:CR1 e1: e10: e11:TLR ligand: TLR: TLR: MyD88 e12:TLR ligand: TLR: TLR: TRIF e13:NF-kappaB {activated} e14:IRF-3 {activated} e15:mannose receptor e16:mannose e17:fucose e18:N-acetyl glucosamine e19:mannose: mannose receptor e2: e20:fucose: mannose receptor e21:N-acetyl glucosamine: mannose receptor e22:mannan e23:mannan: DC-SIGN e24:mannose receptor ligand e25:mannose receptor ligand: mannose receptor e26:IL8 e27:Dectin-1 e28:beta1, 3-glucans: Dectin-1 e29:beta1, 3-glucans e3: e30:MIP-2 e31:MIP-2 e32:IL-23 e33:IL-23 e34:Syk: beta1, 3-glucans: Dectin-1 e35:CARD9 e36:PLA2 {activated} e37:CoxII {activated} e38:Dectin-2 e39:fucose: Dectin-2 e4: e40:mannose: Dectin-2 e41:Ca e42:mannan: DC-SIGN tetratmer e43:DC-SIGN (murine) e44:fungal particle e45:fungal particle: DC-SIGN (murine) e46:Raf kianse e47:Raf kinase (activated} e48:SIRPalpha e49:C1qRp: SP-D e5:TLR liagnd e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR ligand: TLR: TLR e60: e61: e62: e63:C1qRp e64:C1qRp: SP-A e65:SIRPalpha: SP-A e66:calreticulin: SP-A e67:CD14: SP-A e68:cytokines e69:SP-A e7: e70:SP-D e71:mannose receptor e72:SIRPalpha: SP-D e73:calreticulin: SP-D e74:CD14: SP-D e75:MBL: alpha2 beta1 e76:MBL: CR1 e77:MBL: calreticulin e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p6 p7 p8 p9
Model Detail
392.0, 1167.0
34.0, 34.0

GM-CSF

--

G010220

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p16

true true true true

csml-variable:Double

m93209

10

false

infinite

0

unit false false false
TRANSFACG010220

--

Go back
729.0, 1092.0
31.5, 31.5

IL-2

--

G010229

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m93218

10

false

infinite

0

unit false false false
TRANSFACG010229

--

Go back
397.0, 1052.0
32.0, 32.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p15 p22

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
418.0, 1209.0
30.0, 30.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p17 p23 p31 p32

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
396.0, 1003.0
34.0, 34.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
428.0, 899.0
34.0, 34.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
616.0, 971.0
33.5, 33.5

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
228.0, 376.0
34.0, 34.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p11

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
199.0, 1170.0
28.0, 28.0

GM-CSF

--

MO000000099

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

--

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR000773
TRANSPATHMO000000099

--

Go back
281.0, 1300.0
32.0, 32.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p23 p31 p32

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
231.0, 1098.0
28.0, 28.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p22

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
368.0, 263.0
34.0, 34.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
810.0, 781.0
30.0, 30.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
224.0, 323.0
34.0, 34.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
199.0, 1002.0
36.0, 36.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
797.0, 920.0
32.0, 32.0

PLA2

--

MO000016723

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m1675

10

false

infinite

0

unit false false false
InterProIPR001211
TRANSPATHMO000016723

--

Go back
902.0, 1093.0
30.0, 30.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

p20

--

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
215.0, 954.0
28.0, 28.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
230.0, 901.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
556.0, 632.0
32.0, 32.0

calreticulin

--

MO000017520

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p46 p49

true true true true

csml-variable:Double

m2316

10

false

infinite

0

unit false false false
TRANSPATHMO000017520

--

Go back
923.0, 698.0
28.0, 28.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p47

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
914.0, 1217.0
30.0, 30.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41 p42

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
145.0, 276.0
32.0, 32.0

TLR: TLR

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
151.0, 562.0
28.0, 28.0

alpha2 beta1

--

MO000019699

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m4234

10

false

infinite

0

unit false false false
TRANSPATHMO000019699

--

Go back
298.0, 337.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
880.0, 135.0
33.5, 33.5

DC-SIGN

--

MO000042415

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m20214

10

false

infinite

0

unit false false false
TRANSPATHMO000042415

--

Go back
901.0, 748.0
32.0, 32.0

CARD9 {activated}

--

MO000044196

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p26

true true true true

csml-variable:Double

m21914

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044196

--

Go back
45.0, 633.0
30.0, 30.0

MBL

--

MO000062069

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p49 p50

true true true true

csml-variable:Double

m36961

10

false

infinite

0

unit false false false
TRANSPATHMO000062069

--

Go back
774.0, 869.0
30.0, 30.0

CoxII

--

MO000069544

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m44388

10

false

infinite

0

unit false false false
TRANSPATHMO000069544

--

Go back
143.0, 679.0
34.0, 34.0

CR1

--

MO000070528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m45367

10

false

infinite

0

unit false false false
TRANSPATHMO000070528

--

Go back
126.75, 165.99690800911753
904.333236055255, 1313.0918587522287

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
148.0, 246.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
224.875, 165.5
32.25, 45.0

TLR ligand: TLR: TLR: MyD88

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p2

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
296.875, 141.5
32.25, 45.0

TLR ligand: TLR: TLR: TRIF

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
220.0, 447.0
34.0, 34.0

NF-kappaB {activated}

--

e13

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p11

--

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
340.0, 395.0
34.0, 34.0

IRF-3 {activated}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

--

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
504.0, 174.5
18.0, 45.0

mannose receptor

--

e15

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p6 p7 p8 p10 p43

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
558.5, 31.25
45.0, 25.5

mannose

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p6 p30

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
626.5, 23.25
45.0, 25.5

fucose

--

e17

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p7 p29

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
754.5, 84.25
45.0, 25.5

N-acetyl glucosamine

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
568.75, 158.5
24.860430950048972, 67.80117531831537

mannose: mannose receptor

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
126.75, 165.99690800911753
904.333236055255, 1313.0918587522287

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
637.75, 150.5
21.531341821743393, 58.72184133202743

fucose: mannose receptor

--

e20

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
700.75, 135.5
23.998530852105777, 65.4505386875612

N-acetyl glucosamine: mannose receptor

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
902.5, 83.25
45.0, 25.5

mannan

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
813.625, 181.5
30.250416597233798, 37.0413264455924

mannan: DC-SIGN

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p9

p33

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
56.5, 953.375
33.18980667838312, 21.57337434094903

mannose receptor ligand

--

e24

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
155.75, 1021.5
19.301175318315373, 52.63956904995103

mannose receptor ligand: mannose receptor

--

e25

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11 p12 p13 p14 p15 p16 p17 p23 p31 p32

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
400.0, 951.0
34.0, 34.0

IL8

--

e26

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p13

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
Affymetrix1369_s_at
EnsemblENSG00000169429
HGNCIL8
OMIM146930
ProteomeHumanPSD/IL8
RefSeqNM_000584
TRANSFACG000317
UnigeneHs.551925

--

Go back
978.375, 1069.5
29.25, 45.0

Dectin-1

--

e27

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p18

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
977.375, 981.5
23.25, 45.0

beta1, 3-glucans: Dectin-1

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p19 p20 p21 p22 p23 p24 p27 p28

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
1054.5, 955.25
45.0, 25.5

beta1, 3-glucans

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p18

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
144.83666472110505, 184.0835727302226
868.1599066130449, 1276.9185293100193

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
901.5, 1052.125
31.719999999999995, 23.789999999999996

MIP-2

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

p19

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
718.5, 1052.0
45.0, 24.0

MIP-2

--

e31

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p19

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
714.5, 1148.0
45.0, 24.0

IL-23

--

e32

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p21

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
895.5, 1143.125
34.28, 25.709999999999997

IL-23

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

p21

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
968.875, 893.5
32.25, 45.0

Syk: beta1, 3-glucans: Dectin-1

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p25

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
849.0, 760.0
32.0, 32.0

CARD9

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m36

10

false

infinite

0

unit false false false
InterProIPR001315
TRANSPATHMO000044196

--

Go back
705.0, 856.0
32.0, 32.0

PLA2 {activated}

--

e36

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m37

10

false

infinite

0

unit false false false
InterProIPR001211
TRANSPATHMO000016723

--

Go back
786.0, 821.0
30.0, 30.0

CoxII {activated}

--

e37

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000069544

--

Go back
987.0, 252.0
19.310344827586203, 48.275862068965516

Dectin-2

--

e38

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p29 p30

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
982.0, 314.0
22.0, 60.0

fucose: Dectin-2

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p32

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
178.29699445514967, 215.7352359921565
801.239247144956, 1213.6152027861508

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
986.0, 382.0
22.0, 60.0

mannose: Dectin-2

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
311.5, 526.0
31.003954243750893, 31.529444993644965

Ca

--

e41

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p6 p7 p8 p9 p10

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
864.625, 163.5
33.01845525745709, 40.43076153974337

mannan: DC-SIGN tetratmer

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p33

p35

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
963.5, 139.125
34.76, 26.069999999999997

DC-SIGN (murine)

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
945.5, 50.375
30.659050966608074, 19.928383128295252

fungal particle

--

e44

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p34

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
992.625, 199.5
32.87964505915681, 40.260789868355275

fungal particle: DC-SIGN (murine)

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p34

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
715.5, 303.125
34.120000000000005, 25.589999999999996

Raf kianse

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
715.5, 343.125
34.120000000000005, 25.589999999999996

Raf kinase (activated}

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35

p36

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
922.0, 513.0
30.0, 30.0

SIRPalpha

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p45

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSPATHMO000017908

--

Go back
742.5, 462.0
29.803366105649054, 36.4939176803866

C1qRp: SP-D

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
73.0, 79.5
39.437609841827765, 25.634446397188054

TLR liagnd

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
306.0, 865.0
506.1014864767146, 458.97844304312906

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
360.6627303829598, 875.8771218504194
295.9327127629208, 444.8415300130531

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
312.597226080702, 871.1259956463664
492.9070343153109, 446.7264517503965

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
313.5396869493737, 872.0684565150377
491.0221125779672, 444.8415300130531

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
306.0, 865.0
506.1014864767146, 458.97844304312906

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
306.0, 865.0
506.1014864767146, 458.97844304312906

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
313.5396869493737, 872.0684565150377
491.0221125779672, 444.8415300130531

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
675.444660519315, 1053.4921737343443
31.618440098385896, 28.623008931170432

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
592.5081040762035, 1185.4366953483857
89.53378252381356, 81.05163470576821

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
306.0, 865.0
506.1014864767146, 458.97844304312906

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
144.875, 201.5
32.25, 45.0

TLR ligand: TLR: TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2 p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
425.2852727255044, 1068.96622751827
16.027490438697793, 7.716939840854502

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
424.750069452637, 1045.952486784971
54.858335468910596, 98.74500384403908

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
447.76381018593656, 1110.1768795290618
8.563252365878716, 8.563252365878725

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
921.375, 461.5
23.652460456942002, 36.3884007029877

C1qRp

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p37 p44

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
789.625, 416.5
31.23025329111815, 38.24112647892018

C1qRp: SP-A

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
790.625, 510.5
29.18076153974338, 35.73154474254291

SIRPalpha: SP-A

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
784.625, 577.5
31.00979003499417, 37.97117147142143

calreticulin: SP-A

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
789.625, 662.5
29.00929011831361, 35.52157973671054

CD14: SP-A

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
678.5, 1216.0
45.0, 24.0

cytokines

--

e68

cso30:c:mRNA

cso30:i:CC_Cytosol

--

--

p41 p42

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1060.0, 451.0
34.0, 34.0

SP-A

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p38 p39 p40 p41

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSPATHMO000071032

--

Go back
138.0, 171.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1063.0, 614.0
36.0, 36.0

SP-D

--

e70

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42 p44 p45 p46 p47

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000066990

--

Go back
384.0, 69.5
18.0, 45.0

mannose receptor

--

e71

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
740.5, 545.0
30.979170138310288, 37.93367772037994

SIRPalpha: SP-D

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
730.5, 652.0
26.341276453924344, 32.254624229295125

calreticulin: SP-D

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
742.5, 695.0
28.38260289951675, 34.75420763206132

CD14: SP-D

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
144.5, 609.0
31.46092317947009, 38.52357940343276

MBL: alpha2 beta1

--

e75

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p48

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
149.5, 726.0
28.962339610064987, 35.46408931844693

MBL: CR1

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p50

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
300.5, 665.0
31.371104815864037, 38.41359773371105

MBL: calreticulin

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
141.0, 192.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
149.0, 213.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
79.0, 222.0
27.0, 27.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019395 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3962*m6*0.1

nodelay

--

true

0

false

PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).

Go back
132.0, 951.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 e15 e41

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c28 : 1
stoichiometry:c96 : 1
stoichiometry:c30 : 1

m25*m16*m42*0.1

nodelay

--

true

0

false

PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.

Go back
284.0, 451.0
25.0, 25.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000000058

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m26*m5*0.1

nodelay

--

true

0

false

PMID: 18160296, 15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.

Go back
291.0, 902.0
27.0, 27.0

p12

p12

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e25

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c46 : 1
stoichiometry:c34 : 1

m93589*m26*0.1

nodelay

--

true

0

false

PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.

Go back
283.0, 954.0
27.0, 27.0

p13

p13

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e26 e25

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c47 : 1
stoichiometry:c35 : 1

m27*m26*0.1

nodelay

--

true

0

false

PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.

Go back
264.0, 1007.0
25.0, 25.0

p14

p14

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e25

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c48 : 1
stoichiometry:c36 : 1

m93364*m26*0.1

nodelay

--

true

0

false

PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.

Go back
261.0, 1060.0
23.0, 23.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e25

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c49 : 1
stoichiometry:c37 : 1

m93248*m26*0.1

nodelay

--

true

0

false

PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.

Go back
284.0, 1171.0
25.0, 25.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010220 e25

MO000000099

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c50 : 1
stoichiometry:c38 : 1

m93209*m26*0.1

nodelay

--

true

0

false

PMID: 18160296,15668126, 15155616, 17020928 In response to fungi, the MR can induce NF-kappaB activation and the production of several cytokines, including IL-12, IL-8, IL-1beta, IL-6 and granulocyte?macrophage colony-stimulating factor (GM-CSF), and can also enhance MR shedding.

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284.0, 1211.0
25.0, 25.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e25

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c51 : 1
stoichiometry:c39 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).

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1063.0, 1078.0
27.0, 27.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e27 e29

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m28*m30*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 16371356 Although most similar to CLRs with proteinaceous ligands, Dectin-1 recognises beta-1,3-glucans in a calcium-independent fashion through an unknown mechanism and is the major receptor for these carbohydrates on leukocytes.

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832.0, 1051.0
25.0, 25.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e31 e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c144 : 1
stoichiometry:c55 : 1

m32*m29*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.

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227.0, 270.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000016573

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m11*m1572*0.1

nodelay

--

true

0

false

PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).

Go back
829.0, 1096.0
23.0, 23.0

p20

p20

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010229 e28

MO000017061

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c145 : 1
stoichiometry:c56 : 1

m93218*m29*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.

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833.0, 1144.0
23.0, 23.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e32 e28

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c146 : 1
stoichiometry:c57 : 1

m33*m29*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.

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275.0, 1130.0
28.0, 28.0

p22

p22

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010262 e28

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c81 : 1
stoichiometry:c73 : 1

m93248*m29*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.

Go back
371.0, 1282.0
27.0, 27.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010329 e28 e25

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c82 : 1
stoichiometry:c151 : 1
stoichiometry:c75 : 1

m93309*m29*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23. PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).

Go back
905.0, 904.0
23.0, 23.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000008301

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m29*m1066*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 16862125 Signalling from Dectin-1 is mediated through novel pathways, including an unusual interaction with spleen tyrosine kinase (Syk), which triggers downstream signalling through caspase-recruitment domain 9 (CARD9).

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903.0, 818.0
27.0, 27.0

p25

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e35 e34

MO000044196

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c66 : 1
stoichiometry:c65 : 1

m36*m35*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 16862125 Signalling from Dectin-1 is mediated through novel pathways, including an unusual interaction with spleen tyrosine kinase (Syk), which triggers downstream signalling through caspase-recruitment domain 9 (CARD9).

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1046.0, 749.0
30.0, 30.0

p26

p26

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000044196

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1

m21914*0.1

nodelay

--

true

0

false

PMID: 18160296, 17450144 The CARD9 pathway has been shown recently to induce DC maturation and direct T helper 17 (Th17)-cell responses independently of the TLRs, demonstrating that signalling through Dectin-1 can couple to adaptive immunity directly.

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818.0, 993.0
30.0, 30.0

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016723 e28

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c143 : 1
stoichiometry:c78 : 1

m1675*m29*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.

Go back
858.0, 925.0
30.0, 30.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000069544 e28

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c142 : 1
stoichiometry:c80 : 1

m44388*m29*0.1

nodelay

--

true

0

false

PMID: 18160296, 16341139, 17450144 This induces a variety of cellular responses, including the respiratory burst, activation and regulation of phospholipase A2 (PLA2) and cyclooxygenase 2 (COX2), ligand uptake by endocytosis and phagocytosis and the production of several cytokines and chemokines, including TNF, macrophage inflammatory protein 2 (MIP-2), IL-2, IL-10, IL-6 and IL-23.

Go back
1031.0, 262.0
27.0, 27.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c97 : 1
stoichiometry:c85 : 1

m18*m39*0.1

nodelay

--

true

0

false

PMID: 18160296, 16423983 Dectin-2 possesses cation-dependent mannose and fucose lectin activity with specificity for high mannose structures.

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300.0, 259.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000041125

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m11*m18998*0.1

nodelay

--

true

0

false

PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).

Go back
1065.0, 372.0
23.0, 23.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e16 e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c98 : 1
stoichiometry:c86 : 1

m17*m39*0.1

nodelay

--

true

0

false

PMID: 18160296, 16423983 Dectin-2 possesses cation-dependent mannose and fucose lectin activity with specificity for high mannose structures.

Go back
381.0, 1324.0
24.0, 24.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e40 e25

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c92 : 1
stoichiometry:c152 : 1
stoichiometry:c87 : 1

m93309*m41*0.1

nodelay

--

true

0

false

PMID: 18160296, 17050534 The cytoplasmic tail of Dectin-2 appears to associate through a novel interaction with the Fc¦Ã chain, a signalling adaptor associated with several other transmembrane receptors, and can induce TNF and IL-1R antagonist in response to hyphal forms of C. albicans. PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).

Go back
397.0, 1369.0
30.0, 30.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e39 e25

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c153 : 1
stoichiometry:c88 : 1

m93309*m40*0.1

nodelay

--

true

0

false

PMID: 18160296, 17050534 The cytoplasmic tail of Dectin-2 appears to associate through a novel interaction with the Fc¦Ã chain, a signalling adaptor associated with several other transmembrane receptors, and can induce TNF and IL-1R antagonist in response to hyphal forms of C. albicans. PMID: 18160296,16000387 However, with certain fungi, such as Pneumocystis, the MR might have an immunosuppressive role, inhibiting the production inflammatory cytokines, such as tumour necrosis factor (TNF).

Go back
815.0, 242.0
27.0, 27.0

p33

p33

cso30:i:ME_Polymerization

cso30:i:CC_Cytosol

--

e23

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18160296, 15659060 DC-SIGN recognises carbohydrates, such as high-mannose structures, in a Ca2+-dependent fashion with specificity being achieved through unique interactions with its ligands and tetramerisation of the receptor.

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997.0, 92.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e43 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m44*m45*0.1

nodelay

--

true

0

false

PMID: 18160296, 15096474, 14707091 Of the murine homologues, only SIGNR1 (also termed murine DC-SIGN) and SIGNR3 recognise fungal particles.

Go back
818.0, 301.0
30.0, 30.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e46 e42

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c109 : 1
stoichiometry:c106 : 1

m47*m43*0.1

nodelay

--

true

0

false

PMID: 18160296, 17462920, 17496896 DC-SIGN can induce intracellular signalling through the Raf-kinase pathway, modulating TLR-mediated responses and inducing higher levels of the immunosuppressive cytokine IL-10.

Go back
619.0, 918.0
27.0, 27.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e47

G011345

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18160296, 17462920, 17496896 DC-SIGN can induce intracellular signalling through the Raf-kinase pathway, modulating TLR-mediated responses and inducing higher levels of the immunosuppressive cytokine IL-10.

Go back
860.0, 423.0
25.0, 25.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c110 : 1
stoichiometry:c118 : 1

m70*m64*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
860.0, 515.0
25.0, 25.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e69

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c117 : 1
stoichiometry:c119 : 1

m49*m70*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
859.0, 599.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017520 e69

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c130 : 1
stoichiometry:c120 : 1

m2316*m70*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
283.0, 382.0
27.0, 27.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c14 : 1
stoichiometry:c11 : 1

m5*m12*0.1

nodelay

--

true

0

false

PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).

Go back
859.0, 667.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000018132 e69

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c131 : 1
stoichiometry:c121 : 1

m2828*m70*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
831.0, 1194.0
27.0, 27.0

p41

p41

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e68 e69

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c127 : 1
stoichiometry:c122 : 1

m69*m70*0.1

nodelay

--

true

0

false

PMID: 18160296, 11181966 Through unknown mechanisms, SP-A and SP-D can also modulate a variety of host cell functions, such as phagocytosis, cytokine production and the respiratory burst.

Go back
831.0, 1234.0
27.0, 27.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e68 e70

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c123 : 1

m69*m71*0.1

nodelay

--

true

0

false

PMID: 18160296, 11181966 Through unknown mechanisms, SP-A and SP-D can also modulate a variety of host cell functions, such as phagocytosis, cytokine production and the respiratory burst.

Go back
378.0, 137.0
30.0, 30.0

p43

p43

cso30:i:ME_ProteinCleavage

cso30:i:CC_Extracellular

--

e15

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 18160296 A soluble form of the MR is shed into the serum, which is generated through proteolytic cleavage of the membrane-bound receptor.

Go back
860.0, 467.0
25.0, 25.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 e70

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c132 : 1
stoichiometry:c136 : 1

m64*m71*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
859.0, 551.0
25.0, 25.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 e70

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c133 : 1
stoichiometry:c137 : 1

m49*m71*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
859.0, 635.0
25.0, 25.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000017520

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c140 : 1
stoichiometry:c138 : 1

m71*m2316*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
860.0, 699.0
25.0, 25.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000018132

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c141 : 1
stoichiometry:c139 : 1

m71*m2828*0.1

nodelay

--

true

0

false

PMID: 18160296, 16213021 Similar to MBP, these collectins have been proposed to bind directly to cellular receptors, including C1q receptor (C1qRp), signal-regulating protein alpha (SIRPalpha), calreticulin and CD14.

Go back
45.0, 561.0
30.0, 30.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019699 MO000062069

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m4234*m36961*0.1

nodelay

--

true

0

false

PMID: 18160296, 12524383, 16166590 The identity of the MBL receptor(s) is controversial, although a number have been proposed, including calreticulin, complement receptor 1 and the integrin.

Go back
201.0, 633.0
30.0, 30.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000062069 MO000017520

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c150 : 1
stoichiometry:c71 : 1

m36961*m2316*0.1

nodelay

--

true

0

false

PMID: 18160296, 12524383, 16166590 The identity of the MBL receptor(s) is controversial, although a number have been proposed, including calreticulin, complement receptor 1 and the integrin.

Go back
343.0, 334.0
27.0, 27.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007694 e12

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c15 : 1
stoichiometry:c13 : 1

m977*m13*0.1

nodelay

--

true

0

false

PMID:18160296 Ligand recognition, by TLR homo- or hetero-dimers, induces signalling cascades mediated through intracellular adaptors, including myeloid differentiation primary response gene 88 (MyD88) and TIR-domain-containing adaptor-inducing interferon-beta (TRIF), which result in the activation of several transcription factors, such as NF-kappaB and interferon-regulatory factor 3 (IRF3).

Go back
45.0, 729.0
30.0, 30.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000062069 MO000070528

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c148 : 1
stoichiometry:c149 : 1

m36961*m45367*0.1

nodelay

--

true

0

false

PMID: 18160296, 12524383, 16166590 The identity of the MBL receptor(s) is controversial, although a number have been proposed, including calreticulin, complement receptor 1 and the integrin.

Go back
568.0, 83.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e16 e41

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c93 : 1
stoichiometry:c22 : 1

m16*m17*m42*0.1

nodelay

--

true

0

false

PMID: 18160296, 15668126 This activity is mediated by CTLD 4?8 of the receptor, which bind terminal mannose, fucose or N-acetyl glucosamine and is responsible for microbial recognition. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.

Go back
636.0, 83.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e17 e41

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c20 : 1
stoichiometry:c94 : 1
stoichiometry:c23 : 1

m16*m18*m42*0.1

nodelay

--

true

0

false

PMID: 18160296, 15668126 This activity is mediated by CTLD 4?8 of the receptor, which bind terminal mannose, fucose or N-acetyl glucosamine and is responsible for microbial recognition. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.

Go back
683.0, 83.0
27.0, 27.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 e18 e41

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c95 : 1
stoichiometry:c24 : 1

m16*m19*m42*0.1

nodelay

--

true

0

false

PMID: 18160296, 15668126 This activity is mediated by CTLD 4?8 of the receptor, which bind terminal mannose, fucose or N-acetyl glucosamine and is responsible for microbial recognition. PMID: 18160296 A variety of endogenous and exogenous ligands have been described for the various domains of the MR, including the Ca2+-dependent recognition of carbohydrates.

Go back
816.0, 83.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e22 MO000042415 e41

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c99 : 1
stoichiometry:c27 : 1

m23*m20214*m42*0.1

nodelay

--

true

0

false

PMID: 18160296, 2828085 We now know that mannan can be recognised by several mannose-receptors, such as DC-SIGN, and is often contaminated with other carbohydrates involved in fungal recognition, such as beta-glucan. PMID: 18160296, 15659060 DC-SIGN recognises carbohydrates, such as high-mannose structures, in a Ca2+-dependent fashion with specificity being achieved through unique interactions with its ligands and tetramerisation of the receptor.

Go back
112.18458696386072, 252.0745328934242

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.0, 394.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 219.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.0, 210.44044669882695

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 121.91023120718746

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 70.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 115.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.0, 316.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.4353305060856, 322.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.0, 945.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.3779980708965, 369.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.7835508020737, 204.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
257.3343588757586, 409.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.4, 449.8

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 528.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 614.9381318233964

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.1919189506982, 689.5037553862376

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 480.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.0019322835142, 536.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.9064505434782, 439.2198523695652

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.680491366532, 473.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 436.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 528.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
366.00564086991375, 297.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.7920642163135, 600.8121079572823

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.0, 680.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 1212.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
858.0, 1236.5419624322474

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
724.0, 1211.1106351178103

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
724.0, 1231.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.9999961003796, 632.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.9271153270674, 469.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
415.49063342055234, 160.80898753270714

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.0, 123.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0, 361.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.5398594650478, 480.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
889.5618009266198, 485.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.4604587110963, 493.71831254181194

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.6104566867896, 570.4659580325911

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
891.9756430402748, 633.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.4732382146431, 639.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 480.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.0, 564.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.9033562111058, 650.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.0, 712.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
247.0, 211.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.0, 648.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 712.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.9746962014818, 951.9183686525179

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
855.9961568483941, 1004.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
864.3846153846154, 1009.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.5415390113684, 1012.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
861.4956550121794, 1016.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
60.0, 663.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
82.19725330264248, 704.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 744.0

c149

c149

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
318.0, 187.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
239.0, 648.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
175.0, 1059.0

c151

c151

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
175.0, 1061.0

c152

c152

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
175.0, 1062.0

c153

c153

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
522.0, 114.64292457717568

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 57.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.0, 110.7455923043988

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.0, 108.8032219057972

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
93.0, 105.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 49.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.0, 97.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
581.0, 108.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
649.0, 108.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 110.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
849.0, 96.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.1845869638607, 111.07453289342419

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 108.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
29.136080829167497, 60.17494934861861

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
90.0, 964.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.0, 228.41331250235018

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.0, 976.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
171.0, 483.80441861149984

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
257.0, 410.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
262.0, 464.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.0, 916.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 968.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.0, 1020.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
259.4376015698018, 1083.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.0, 1184.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
297.0, 1236.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
177.0, 236.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.0, 916.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
318.0, 968.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
297.0, 1020.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
291.9949925666012, 1068.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.0, 1184.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.0, 1224.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 934.5047326640744

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 980.1716000756318

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 1024.9197461660485

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 1050.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
241.0, 305.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
175.0, 1058.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
175.0, 1061.0

c51

c51

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1008.0, 1092.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.0, 981.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.6568542494924, 1021.6568542494924

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
857.0, 1064.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0, 1108.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.0, 1156.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.0, 1064.0

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.0, 1108.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
241.0, 219.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.0, 1156.3284898516167

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
931.0335858293437, 933.2179589656599

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.0, 811.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.0, 916.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 792.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 788.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.0124552945973, 851.2350053664503

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
83.0, 576.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
60.0, 599.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 584.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
177.0, 229.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 648.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.0, 653.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
309.8406049956609, 1078.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.4, 1126.8

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
398.47313334622226, 1239.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.8063166161281, 1299.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.0, 764.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
817.0, 952.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.1041429180026, 894.1601724872445

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.0, 894.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 292.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.5995641337032, 857.5455335748853

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.8441974602828, 1006.0

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
405.2020604293372, 1010.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.0, 35.506115502967674

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
580.5320746681934, 11.951847120610836

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.824866198974, 289.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1015.548799857063, 388.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.8356563460532, 1320.6132233653639

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
319.87434307527764, 1329.0918708781414

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.7410427608056, 1239.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
313.0, 195.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0373220331253, 1239.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.9995128863246, 343.92429667435965

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
412.99999984644046, 412.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.0, 114.95207778282341

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
339.0, 114.49198013605053

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 116.1506150681592

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
154.16037982775833, 558.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 276.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 289.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.0, 113.31177001521395

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back