1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18163952.csml convertedTime:2009.07.01.11:13

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The interferon signaling network and transcription factor C/EBP-beta.
Authors Li H, Gade P, Xiao W, Kalvakolanu DV.
Affiliation Department of Microbiology & Immunology, Greenebaum Cancer Center, University ofMaryland School of Medicine, 660 W. Redwood Street, Baltimore, MD 21201, USA.
Abstract Cytokines like interferons (IFNs) play a central role in regulating innate andspecific immunities against the pathogens and neoplastic cells. A number ofsignaling pathways are induced in response to IFN in various cells. One classicmechanism employed by IFNs is the JAK-STAT signaling pathway for inducingcellular responses. Here we describe the non-STAT pathways that participate inIFN-induced responses. In particular, we will focus on the role played bytranscription factor C/EBP-beta in mediating these responses.
PMID 18163952
Model Abstract

Entity

G010291:G-CSF G010329:TNF-alpha G010787:C/EBPbeta MO000000003:Ras family MO000000009:Raf MO000000011:ERK MO000000012:Grb-2 MO000000021:Cdc42 MO000000022:p38 MO000000023:JNK MO000000030:PI3K MO000000038:Elk-1 MO000000047:MEKK1 MO000000048:AKT MO000000049:c-Jun MO000000051:RSK MO000000057:Rac MO000000058:NF-kappaB MO000000060:MEKKs MO000000078:MEK1 MO000000104:PKC MO000000145:Jak1 MO000000146:Jak2 MO000000148:Tyk2 MO000000214:IL-1 MO000000279:c-Fos MO000000289:TNF-alpha MO000004670:ERK1 MO000004676:ERK2 MO000004690:p38gamma MO000006031:glucagon MO000007384:IL-6 MO000007500:IFNGR2 MO000007545:IFNAR1 MO000007548:IFNAR2 MO000009617:c-Myb MO000011894:pRb MO000013119:STAT1 MO000013120:STAT2 MO000013122:STAT3 MO000016580:C/EBPbeta MO000016660:IFNbeta MO000016665:IFNgamma MO000016777:Sos MO000016835:IFNGR1 MO000016845:STAT2{pY}:STAT1{pY} MO000016849:STAT2{pY} MO000016876:STAT5 MO000016878:CrkL MO000016913:MLK3 MO000016917:MKK4 MO000016958:p38alpha MO000016959:p38beta MO000016961:p38delta MO000017140:mTOR MO000017181:STAT4 MO000017190:Egr-1 MO000017369:Rho MO000017545:Cdk2 MO000019417:C/EBPalpha MO000019457:IFNAR1:Tyk2 MO000019460:IFNGR1:Jak1 MO000019704:STAT1{p} MO000021607:STAT3{p} MO000032346:STAT5{pY} MO000033284:Sp1 MO000033720:STAT4{pY} MO000037579:PU.1 MO000038364:Elk-1{p} MO000038368:p38alpha{p} MO000038382:p38beta{p} MO000038483:IFNAR1:Tyk2:IFNAR2:Jak1 MO000038484:IFNAR2:Jak1 MO000038589:c-Jun{p} MO000038670:MEK1{p} MO000038672:ERK1{p} MO000038692:ERK2{p} MO000042106:p38gamma{p} MO000042108:p38delta{p} MO000042409:LPS MO000080026:CrkL{pY} e1: e10: e100:p38 e11:IRF9 e12:IFNbeta:IFNAR1:Tyk2:IFNAR2:Jak1 e13:STAT1{p}:STAT2{p}:IRF9 e14:ISRE e15:ISRE:STAT1{p}:STAT2{p}:IRF9 e16:IFN inducible genes e17:IFNGR2:Jak2 e18:IFNGR1:JAK1:IFNGR2:JAK2 e19:IFNGR1:JAK1:IFNGR2:JAK2:IFNgamma e2: e20:(STAT1{p})2 e21:(STAT1{p})2 e22:GAS e23:GAS:(stat1{p})2 e24:IFNgamma inducible genes e25:type III IFN:type III IFN receptor e26:type III IFN receptor e27:type III IFN e28:PI3K{active} e29:AKT e3: e30:mTOR e31:C/EBPbeta e32:IL-1 e33:IL8 e34:CRP e35:alpha2-microglobulin e36:¦Á1-acid glycoprotein e37:C/EBPbeta:STAT3 e38:C/EBPbeta:NF-kappaB e39:C/EBPbeta:SP1 e4: e40:C/EBPbeta:pRb e41:LIP e42:C/EBPbeta:LIP e43:C/EBPzeta e44:C/EBPzeta:C/ebpbeta e45:C/EBPzeta:C/EBPalpha e46:Dexamethasone e47:C?EBPbeta{p} e48:GATE e49:C/EBPbeta:GATE e5:IFNalpha:IFNAR1:Tyk2:IFNAR2:Jak1 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:IFNalpha e60: e61: e62: e63:PKA e64:pu.1:C/EBPbeta e65:C/EBPbeta:c-myb e66:IRF9 e67:2-5A synthatase e68:MHC I e69:Rho{active} e7: e70:growth factor e71:growth factor:growth factor receptor e72:growth factor receptor e73:growth factor:growth factor receptor:GRB2:SOS e74:Ras family e75:Raf e76:c-fos{p} e77:Egr-1{p} e78:Rac e79:MEKKs{active} e8: e80:MKK4{active} e81:SEK2{active} e82:SEK2 e83:JNK e84:MEKK1{active} e85:ERK e86:MEKK1:MEk1:ERK1:ERK2 e87:NF-kappaB{active} e88:IFN-beta e89:transcription mediator complex e9: e90:C/EBPbeta:transcription mediator complex e91:GATE:GBF1 e92:GBF1 e93:C/EBPbeta{p}:GBF1 e94:IRF9 e95:C/EBPbeta:GBF1:IRF9 e96:MLKs:Cdc42 e97:MLKs e98:(MLKs)2:Cdc42 e99:(MLKs{p})2:Cdc42

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
1247.0, 1403.0
26.0, 26.0

G-CSF

--

G010291

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p41

--

true true true true

csml-variable:Double

m93274

10

false

infinite

0

unit false false false
TRANSFACG010291

--

Go back
1129.0, 1345.0
30.0, 30.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
702.0, 1498.0
28.0, 28.0

C/EBPbeta

--

G010787

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p51 p52 p53 p54 p55 p56

--

true true true true

csml-variable:Double

m93693

10

false

infinite

0

unit false false false
TRANSFACG010787

--

Go back
472.0, 908.0
32.0, 32.0

Ras family

--

MO000000003

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

p71 p111

true true true true

csml-variable:Double

m80

10

false

infinite

0

unit false false false
TRANSPATHMO000000003

--

Go back
587.0, 847.0
18.0, 18.0

Raf

--

MO000000009

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71 p83 p84

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000000009

--

Go back
1477.0, 785.0
22.0, 22.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

p104

p57

true true true true

csml-variable:Double

m66

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
487.0, 735.0
26.0, 26.0

Grb-2

--

MO000000012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m78

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000012

--

Go back
1466.0, 1650.0
36.0, 36.0

Cdc42

--

MO000000021

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p117

true true true true

csml-variable:Double

m112

10

false

infinite

0

unit false false false
InterProIPR003577
TRANSPATHMO000000021

--

Go back
812.0, 748.0
23.0, 23.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p123

true true true true

csml-variable:Double

m117

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1349.0, 634.0
33.0, 33.0

JNK

--

MO000000023

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p93 p94 p109 p121

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
1225.0, 325.0
30.0, 30.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p32

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
555.0, 1162.0
27.0, 27.0

Elk-1

--

MO000000038

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75 p76

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000000038

--

Go back
805.0, 926.0
33.0, 33.0

MEKK1

--

MO000000047

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p103

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000047

--

Go back
1141.0, 693.0
30.0, 30.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
537.0, 1260.5
30.5, 30.5

c-Jun

--

MO000000049

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77 p78

true true true true

csml-variable:Double

m86

10

false

infinite

0

unit false false false
InterProIPR002112
TRANSPATHMO000000049

--

Go back
1322.0, 822.0
28.0, 28.0

RSK

--

MO000000051

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000051

--

Go back
1382.0, 266.0
28.0, 28.0

Rac

--

MO000000057

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86 p87

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
TRANSPATHMO000000057

--

Go back
1256.0, 1148.0
32.0, 32.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p108 p120

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1434.0, 470.0
28.0, 28.0

MEKKs

--

MO000000060

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p89 p90

true true true true

csml-variable:Double

m91

10

false

infinite

0

unit false false false
TRANSPATHMO000000060

--

Go back
524.0, 1012.0
24.0, 24.0

MEK1

--

MO000000078

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p72 p106 p107

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000078

--

Go back
1234.0, 724.0
26.0, 26.0

PKC

--

MO000000104

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m92

10

false

infinite

0

unit false false false
TRANSPATHMO000000104

--

Go back
674.0, 270.0
28.0, 28.0

Jak1

--

MO000000145

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p14

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000145

--

Go back
1226.0, 270.0
28.0, 28.0

Jak2

--

MO000000146

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000146

--

Go back
521.0, 261.0
30.0, 30.0

Tyk2

--

MO000000148

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m132

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000148

--

Go back
763.0, 1903.0
26.0, 26.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p87 p88

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
707.0, 1051.0
18.0, 18.0

c-Fos

--

MO000000279

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p79 p80

true true true true

csml-variable:Double

m221

10

false

infinite

0

unit false false false
InterProIPR002114
TRANSPATHMO000000279

--

Go back
1716.0, 272.0
24.0, 24.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85 p86

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
529.0, 1129.0
22.0, 22.0

ERK1

--

MO000004670

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73 p106

true true true true

csml-variable:Double

m549

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004670

--

Go back
552.0, 971.5
32.5, 32.5

ERK2

--

MO000004676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74 p106

true true true true

csml-variable:Double

m554

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004676

--

Go back
1083.0, 639.0
33.0, 33.0

p38gamma

--

MO000004690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p99 p100

true true true true

csml-variable:Double

m567

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000004690

--

Go back
321.0, 1585.0
30.0, 30.0

glucagon

--

MO000006031

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m740

10

false

infinite

0

unit false false false
TRANSPATHMO000006031

--

Go back
1645.0, 1077.0
30.0, 30.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p53 p66 p67

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
1175.0, 199.0
26.0, 26.0

IFNGR2

--

MO000007500

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m881

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000007500

--

Go back
479.0, 199.0
34.0, 34.0

IFNAR1

--

MO000007545

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m898

10

false

infinite

0

unit false false false
InterProIPR003961
TRANSPATHMO000007545

--

Go back
633.0, 201.0
30.0, 30.0

IFNAR2

--

MO000007548

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m901

10

false

infinite

0

unit false false false
InterProIPR000282
TRANSPATHMO000007548

--

Go back
1251.0, 1019.0
26.0, 26.0

c-Myb

--

MO000009617

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m1158

10

false

infinite

0

unit false false false
InterProIPR001005
TRANSPATHMO000009617

--

Go back
1285.0, 1105.0
30.0, 30.0

pRb

--

MO000011894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m1320

10

false

infinite

0

unit false false false
InterProIPR006670
TRANSPATHMO000011894

--

Go back
826.0, 310.0
28.0, 28.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p7 p18 p24

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
977.0, 313.0
30.0, 30.0

STAT2

--

MO000013120

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9 p25

true true true true

csml-variable:Double

m1358

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013120

--

Go back
544.0, 392.0
32.0, 32.0

STAT3

--

MO000013122

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26 p44

true true true true

csml-variable:Double

m1360

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013122

--

Go back
1454.0, 1018.0
28.0, 28.0

C/EBPbeta

--

MO000016580

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p57 p58 p59 p60 p111 p125 p126

true true true true

csml-variable:Double

m1576

10

false

infinite

0

unit false false false
InterProIPR004827
TRANSPATHMO000016580

--

Go back
996.0, 56.0
32.0, 32.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p83

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1394.0, 34.0
28.0, 28.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p55 p84 p103 p113 p114 p115 p124 p125 p126

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
555.0, 751.0
26.0, 26.0

Sos

--

MO000016777

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m1720

10

false

infinite

0

unit false false false
TRANSPATHMO000016777

--

Go back
1045.0, 197.0
30.0, 30.0

IFNGR1

--

MO000016835

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m1772

10

false

infinite

0

unit false false false
InterProIPR008355
TRANSPATHMO000016835

--

Go back
888.0, 564.0
24.0, 24.0

STAT2{pY}:STAT1{pY}

--

MO000016845

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p11

true true true true

csml-variable:Double

m1780

10

false

infinite

0

unit false false false
TRANSPATHMO000016845

--

Go back
973.0, 448.5
30.5, 30.5

STAT2{pY}

--

MO000016849

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p9 p25

p10

true true true true

csml-variable:Double

m1783

10

false

infinite

0

unit false false false
TRANSPATHMO000016849

--

Go back
513.0, 629.0
30.0, 30.0

STAT5

--

MO000016876

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m1798

10

false

infinite

0

unit false false false
TRANSPATHMO000016876

--

Go back
608.0, 303.5
24.5, 24.5

CrkL

--

MO000016878

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p114

true true true true

csml-variable:Double

m1799

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000016878

--

Go back
1473.0, 1525.0
22.0, 22.0

MLK3

--

MO000016913

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p124 p126

true true true true

csml-variable:Double

m1828

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000016913

--

Go back
1328.0, 444.0
32.0, 32.0

MKK4

--

MO000016917

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p91 p122

true true true true

csml-variable:Double

m1832

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
1124.0, 404.0
32.0, 32.0

p38alpha

--

MO000016958

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30 p95 p96

true true true true

csml-variable:Double

m1867

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016958

--

Go back
1007.0, 543.0
34.0, 34.0

p38beta

--

MO000016959

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p97 p98

true true true true

csml-variable:Double

m1868

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016959

--

Go back
961.0, 781.0
30.0, 30.0

p38delta

--

MO000016961

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p101 p102

true true true true

csml-variable:Double

m1870

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016961

--

Go back
1210.0, 850.0
28.0, 28.0

mTOR

--

MO000017140

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m2018

10

false

infinite

0

unit false false false
InterProIPR003151
TRANSPATHMO000017140

--

Go back
597.0, 473.0
30.0, 30.0

STAT4

--

MO000017181

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m2053

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000017181

--

Go back
621.0, 1237.0
30.0, 30.0

Egr-1

--

MO000017190

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p81 p82

true true true true

csml-variable:Double

m2058

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000017190

--

Go back
1479.0, 267.0
34.0, 34.0

Rho

--

MO000017369

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85 p88

true true true true

csml-variable:Double

m2203

10

false

infinite

0

unit false false false
TRANSPATHMO000017369

--

Go back
936.0, 1020.0
32.0, 32.0

Cdk2

--

MO000017545

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p125

true true true true

csml-variable:Double

m2337

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017545

--

Go back
1345.0, 1389.0
30.0, 30.0

C/EBPalpha

--

MO000019417

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m3982

10

false

infinite

0

unit false false false
InterProIPR000217
TRANSPATHMO000019417

--

Go back
559.0, 199.0
26.0, 26.0

IFNAR1:Tyk2

--

MO000019457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p3

true true true true

csml-variable:Double

m4019

10

false

infinite

0

unit false false false
TRANSPATHMO000019457

--

Go back
1109.0, 201.0
30.0, 30.0

IFNGR1:Jak1

--

MO000019460

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

p16

true true true true

csml-variable:Double

m4021

10

false

infinite

0

unit false false false
TRANSPATHMO000019460

--

Go back
812.0, 436.0
32.0, 32.0

STAT1{p}

--

MO000019704

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p7 p18 p24

p10 p19

true true true true

csml-variable:Double

m4238

10

false

infinite

0

unit false false false
TRANSPATHMO000019704

--

Go back
506.0, 522.0
36.0, 36.0

STAT3{p}

--

MO000021607

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m5950

10

false

infinite

0

unit false false false
TRANSPATHMO000021607

--

Go back
487.0, 687.0
34.0, 34.0

STAT5{pY}

--

MO000032346

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

--

true true true true

csml-variable:Double

m11303

10

false

infinite

0

unit false false false
TRANSPATHMO000032346

--

Go back
1485.0, 1205.0
30.0, 30.0

Sp1

--

MO000033284

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m11975

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000033284

--

Go back
597.0, 609.0
30.0, 30.0

STAT4{pY}

--

MO000033720

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

--

true true true true

csml-variable:Double

m12383

10

false

infinite

0

unit false false false
TRANSPATHMO000033720

--

Go back
1189.0, 1089.0
30.0, 30.0

PU.1

--

MO000037579

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p63

true true true true

csml-variable:Double

m15836

10

false

infinite

0

unit false false false
InterProIPR002341
TRANSPATHMO000037579

--

Go back
625.0, 1197.0
21.0, 21.0

Elk-1{p}

--

MO000038364

cso30:c:Protein

cso30:i:CC_CellComponent

--

p75 p76

--

true true true true

csml-variable:Double

m16574

10

false

infinite

0

unit false false false
TRANSPATHMO000038364

--

Go back
1128.0, 540.0
24.0, 24.0

p38alpha{p}

--

MO000038368

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29 p30 p95 p96

--

true true true true

csml-variable:Double

m16578

10

false

infinite

0

unit false false false
TRANSPATHMO000038368

--

Go back
1008.0, 648.0
32.0, 32.0

p38beta{p}

--

MO000038382

cso30:c:Protein

cso30:i:CC_CellComponent

--

p97 p98

--

true true true true

csml-variable:Double

m16592

10

false

infinite

0

unit false false false
TRANSPATHMO000038382

--

Go back
794.0, 202.0
28.0, 28.0

IFNAR1:Tyk2:IFNAR2:Jak1

--

MO000038483

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p4 p5

true true true true

csml-variable:Double

m16693

10

false

infinite

0

unit false false false
TRANSPATHMO000038483

--

Go back
716.0, 208.0
24.0, 24.0

IFNAR2:Jak1

--

MO000038484

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3

true true true true

csml-variable:Double

m16694

10

false

infinite

0

unit false false false
TRANSPATHMO000038484

--

Go back
563.0, 1363.0
26.0, 26.0

c-Jun{p}

--

MO000038589

cso30:c:Protein

cso30:i:CC_CellComponent

--

p77 p78

--

true true true true

csml-variable:Double

m16780

10

false

infinite

0

unit false false false
TRANSPATHMO000038589

--

Go back
489.0, 1101.0
30.0, 30.0

MEK1{p}

--

MO000038670

cso30:c:Protein

cso30:i:CC_CellComponent

--

p72 p107

p73 p74

true true true true

csml-variable:Double

m16860

10

false

infinite

0

unit false false false
TRANSPATHMO000038670

--

Go back
497.0, 1229.0
30.0, 30.0

ERK1{p}

--

MO000038672

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

p75 p77 p80 p82

true true true true

csml-variable:Double

m16862

10

false

infinite

0

unit false false false
TRANSPATHMO000038672

--

Go back
600.0, 1056.0
24.0, 24.0

ERK2{p}

--

MO000038692

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

p76 p78 p79 p81

true true true true

csml-variable:Double

m16878

10

false

infinite

0

unit false false false
TRANSPATHMO000038692

--

Go back
1061.0, 765.0
30.0, 30.0

p38gamma{p}

--

MO000042106

cso30:c:Protein

cso30:i:CC_CellComponent

--

p99 p100

--

true true true true

csml-variable:Double

m19920

10

false

infinite

0

unit false false false
TRANSPATHMO000042106

--

Go back
963.0, 887.0
26.0, 26.0

p38delta{p}

--

MO000042108

cso30:c:Protein

cso30:i:CC_CellComponent

--

p101 p102

--

true true true true

csml-variable:Double

m19922

10

false

infinite

0

unit false false false
TRANSPATHMO000042108

--

Go back
242.0, 1474.0
36.0, 36.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
664.0, 436.0
24.0, 24.0

CrkL{pY}

--

MO000080026

cso30:c:Protein

cso30:i:CC_CellComponent

--

p114

--

true true true true

csml-variable:Double

m54489

10

false

infinite

0

unit false false false
TRANSPATHMO000080026

--

Go back
387.1653076987427, 177.86655915411689
1234.3590869115494, 1684.7143606883149

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
442.0582715555366, 232.6166380595754
1196.4719486566164, 1582.0782512370613

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
814.0, 862.0
27.0, 27.0

p38

--

e100

cso30:c:Protein

cso30:i:CC_CellComponent

--

p123

--

true true true true

csml-variable:Double

m118

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
929.0, 656.94
30.08, 22.560000000000002

IRF9

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
954.0, 198.0
28.0, 28.0

IFNbeta:IFNAR1:Tyk2:IFNAR2:Jak1

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p7 p9 p30 p31

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000038483

--

Go back
888.5, 743.746191961828
23.83189576069003, 33.25380803817214

STAT1{p}:STAT2{p}:IRF9

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p12

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
838.0, 1241.5
60.0, 13.0

ISRE

--

e14

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p12

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1002.0, 1239.5
60.0, 17.0

ISRE:STAT1{p}:STAT2{p}:IRF9

--

e15

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p12

p13

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1044.0, 1341.1591695501731
40.951557093425606, 21.840830449826992

IFN inducible genes

--

e16

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13

p35

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1265.0, 201.0
30.0, 30.0

IFNGR2:Jak2

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

p16

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
TRANSPATHMO000019460

--

Go back
1329.0, 197.23529411764707
22.058823529411768, 36.76470588235294

IFNGR1:JAK1:IFNGR2:JAK2

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1396.0, 196.29411764705878
23.823529411764707, 39.70588235294118

IFNGR1:JAK1:IFNGR2:JAK2:IFNgamma

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p18

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
387.1653076987427, 177.86655915411689
1234.3590869115494, 1684.7143606883149

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
726.5, 600.3839360106649
19.28645225795701, 23.61606398933511

(STAT1{p})2

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p20

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
802.5, 1260.383936010665
19.28645225795701, 23.61606398933511

(STAT1{p})2

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
750.0, 1337.5
60.0, 13.0

GAS

--

e22

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p21

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
862.0, 1315.5
60.0, 17.0

GAS:(stat1{p})2

--

e23

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p21

p22

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
978.0, 1294.81660899654
35.968858131487885, 19.18339100346021

IFNgamma inducible genes

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p22

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
441.5, 360.07454505590874
20.628151721113788, 39.92545494409121

type III IFN:type III IFN receptor

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24 p25 p26 p27 p28

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
441.5, 285.07908611599294
29.198594024604567, 44.920913884007035

type III IFN receptor

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
236.0, 335.711712618233
40.1972227812437, 24.788287381766953

type III IFN

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1241.0, 453.0
30.0, 30.0

PI3K{active}

--

e28

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31 p32

p33

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1145.0, 793.0
30.0, 30.0

AKT

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

p34

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
411.8524894369736, 201.0719911195206
1184.9847234350882, 1638.3034967575084

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1210.0, 994.0
28.0, 28.0

mTOR

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

p35

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR003151
TRANSPATHMO000017140

--

Go back
1454.0, 1150.0
28.0, 28.0

C/EBPbeta

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p37 p39 p40 p41 p38 p42 p43 p44 p45 p46 p47 p48 p49 p61 p63 p64 p65

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR004827
TRANSPATHMO000016580

--

Go back
1151.0, 1290.508650519031
34.67128027681661, 18.49134948096886

IL-1

--

e32

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1190.0, 1326.3183391003458
36.90311418685121, 19.681660899653984

IL8

--

e33

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p39

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
1178.0, 1428.3598615916958
44.325259515570934, 23.640138408304498

CRP

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1264.0, 1475.8650519031144
32.128027681660896, 17.134948096885815

alpha2-microglobulin

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p42

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1089.0, 1293.5432525951558
38.35640138408304, 20.456747404844293

¦Á1-acid glycoprotein

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p43

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1410.5, 1027.2954507582067
26.708715214130976, 32.70454924179303

C/EBPbeta:STAT3

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1414.0, 1308.9447513812154
27.04972375690608, 30.055248618784535

C/EBPbeta:NF-kappaB

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1476.5, 1273.6547242126312
23.148641893017828, 28.345275787368763

C/EBPbeta:SP1

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
457.52377565270115, 241.68149705897707
1093.6421510036337, 1557.0844848785944

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1349.5, 987.1643059490086
21.09915014164306, 25.83569405099151

C/EBPbeta:pRb

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1493.5, 1022.5987120144898
21.2141275910646, 34.401287985510166

LIP

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p48

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1494.0, 840.779005524862
27.19889502762431, 30.220994475138124

C/EBPbeta:LIP

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1478.0, 1342.02
36.64, 27.48

C/EBPzeta

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49 p50

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1476.0, 1405.5359116022098
32.81767955801105, 36.46408839779006

C/EBPzeta:C/ebpbeta

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1417.5, 1455.0741543076156
20.356107315447424, 24.92584569238461

C/EBPzeta:C/EBPalpha

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
294.0, 1395.9932716568544
44.12952060555088, 25.0067283431455

Dexamethasone

--

e46

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p56

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1378.0, 828.3658536585365
28.292682926829265, 22.634146341463406

C?EBPbeta{p}

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

p57 p58 p59 p60 p111 p125 p126

p112 p115

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1038.0, 1481.5
60.0, 13.0

GATE

--

e48

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p61 p113

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1114.0, 1527.5
60.0, 17.0

C/EBPbeta:GATE

--

e49

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p61

p62

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
874.0, 206.0
28.0, 28.0

IFNalpha:IFNAR1:Tyk2:IFNAR2:Jak1

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4

p6 p8 p29 p32

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000038483

--

Go back
648.4501197040589, 1193.439301267941
671.2678138203323, 572.2273909841679

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
720.952043729346, 1207.0002585464886
392.5104162748314, 554.6023173398917

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
657.2003519140073, 1201.0768331804604
653.7673494004357, 556.9523271591287

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
658.4503850868572, 1202.2518380900792
651.2672830547361, 554.6023173398917

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
648.4501197040589, 1193.439301267941
671.2678138203323, 572.2273909841679

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
648.4501197040589, 1193.439301267941
671.2678138203323, 572.2273909841679

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
658.4503850868572, 1202.2518380900792
651.2672830547361, 554.6023173398917

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1138.4631234611725, 1428.4402831916248
41.93712472375664, 35.685488002888846

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
1028.4602042503914, 1592.9409705382013
118.75315142072915, 101.05042222718369

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
648.4501197040589, 1193.439301267941
671.2678138203323, 572.2273909841679

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
853.0, 38.4056148118334
45.55846246729725, 28.094385188166633

IFNalpha

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
806.6641664574973, 1447.7324254674481
21.258065339244855, 9.621027781252469

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
805.9542994831313, 1419.0402439146774
72.76136487248256, 123.10947666247262

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
836.4785793808558, 1499.111448247993
11.35787158985092, 10.676160577775399

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1428.0, 806.0327408793264
15.15247895229186, 34.967259120673525

PKA

--

e63

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p58

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1098.0, 903.8453038674035
28.939226519337012, 32.15469613259669

pu.1:C/EBPbeta

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1282.0, 913.011049723757
19.790055248618785, 21.988950276243088

C/EBPbeta:c-myb

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1002.0, 1432.0795847750865
27.975778546712803, 14.920415224913498

IRF9

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p65 p105 p124

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1205.0, 1581.7093425605538
38.04498269896193, 20.290657439446367

2-5A synthatase

--

e67

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p66

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1163.0, 1501.0761245674742
41.10726643598616, 21.923875432525957

MHC I

--

e68

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p67

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1479.0, 399.0
34.0, 34.0

Rho{active}

--

e69

cso30:c:Protein

cso30:i:CC_CellComponent

--

p85 p88

p89

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
TRANSPATHMO000017369

--

Go back
403.3829856852798, 241.6459829235909
1210.5217013276686, 1612.3252524810698

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
158.0, 768.9753471523445
36.52646407727913, 22.52465284765546

growth factor

--

e70

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p68

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
420.5, 789.2071914053935
23.14295110721333, 44.79280859460645

growth factor:growth factor receptor

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p68

p69

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
414.5, 723.3831282952548
27.05096660808436, 41.616871704745165

growth factor receptor

--

e72

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p68

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
417.0, 861.3529411764706
22.588235294117652, 37.64705882352941

growth factor:growth factor receptor:GRB2:SOS

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p69

p70

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
540.0, 808.0
32.0, 32.0

Ras family

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000000003

--

Go back
487.0, 979.0
17.0, 17.0

Raf

--

e75

cso30:c:Protein

cso30:i:CC_CellComponent

--

p71 p83 p84

p72

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
TRANSPATHMO000000009

--

Go back
704.0, 1183.048780487805
32.4390243902439, 25.95121951219512

c-fos{p}

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

p79 p80

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
632.0, 1343.048780487805
32.4390243902439, 25.95121951219512

Egr-1{p}

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p81 p82

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
1342.0, 362.0
28.0, 28.0

Rac

--

e78

cso30:c:Protein

cso30:i:CC_CellComponent

--

p86 p87

p90

true true true true

csml-variable:Double

m90

10

false

infinite

0

unit false false false
TRANSPATHMO000000057

--

Go back
1434.0, 610.0
28.0, 28.0

MEKKs{active}

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p89 p90

p91 p92

true true true true

csml-variable:Double

m93

10

false

infinite

0

unit false false false
TRANSPATHMO000000060

--

Go back
407.7076998150229, 270.10196562756755
1161.267892382253, 1584.9558816775864

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1316.0, 576.0
32.0, 32.0

MKK4{active}

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

p91 p122

p94 p96 p98 p100 p102

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016917

--

Go back
1499.0, 631.7745556594948
17.864359214218897, 41.22544434050514

SEK2{active}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p92

p93 p95 p97 p99 p101

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1504.0, 513.3105706267539
16.33208606173994, 37.68942937324602

SEK2

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p92

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1343.0, 763.0
33.0, 33.0

JNK

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93 p94 p109 p121

--

true true true true

csml-variable:Double

m98

10

false

infinite

0

unit false false false
TRANSPATHMO000000023

--

Go back
804.0, 1060.0
31.0, 31.0

MEKK1{active}

--

e84

cso30:c:Protein

cso30:i:CC_CellComponent

--

p103

p104 p105 p106 p107 p108 p109 p110

true true true true

csml-variable:Double

m100

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000047

--

Go back
1461.0, 717.0
22.0, 22.0

ERK

--

e85

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p104

true true true true

csml-variable:Double

m101

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
728.0, 895.8529411764705
24.088235294117645, 40.14705882352941

MEKK1:MEk1:ERK1:ERK2

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p106

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1120.0, 1164.0
32.0, 32.0

NF-kappaB{active}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p108 p120

--

true true true true

csml-variable:Double

m103

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
759.0, 1382.4256055363323
34.82698961937716, 18.57439446366782

IFN-beta

--

e88

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p110

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
1043.5, 1636.7250458256954
24.724545909015163, 30.27495417430428

transcription mediator complex

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p112

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
419.24027082767134, 298.55794833154414
1155.96606745815, 1564.1695824433928

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1113.0, 1685.0882352941176
22.14705882352941, 36.91176470588235

C/EBPbeta:transcription mediator complex

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p112

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
982.0, 1579.5
60.0, 17.0

GATE:GBF1

--

e91

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p113

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
976.0, 1482.3879050110686
32.61420809015899, 20.11209498893137

GBF1

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p113 p115

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
909.5, 1406.5544075987336
21.597233794367604, 26.445592401266456

C/EBPbeta{p}:GBF1

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p115

p116

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
829.0, 1449.7589546298755
54.18944016980632, 11.7410453701247

IRF9

--

e94

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p116

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
831.0, 1561.5575983543329
42.149652867060944, 11.942401645667267

C/EBPbeta:GBF1:IRF9

--

e95

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p116

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1407.5, 1712.5750708215298
24.847025495750707, 30.424929178470258

MLKs:Cdc42

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p117

p118

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
1409.5, 1570.212316361441
21.452404910444756, 34.787683638559066

MLKs

--

e97

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p117 p120 p121 p122 p123

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1286.0, 1710.441176470588
20.735294117647058, 34.55882352941176

(MLKs)2:Cdc42

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p118

p119

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
1338.0, 1591.9411764705883
19.235294117647058, 32.05882352941176

(MLKs{p})2:Cdc42

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p119

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
502.0, 102.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007545 MO000000148

MO000019457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m898*m132*0.1

nodelay

--

true

0

false

PMID: 18163952 From fig.1

Go back
890.0, 470.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019704 MO000016849

MO000016845

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m4238*m1783*0.1

nodelay

--

true

0

false

PMID: 18163952, 8417326 After being activated (i.e. tyrosyl phosphorylated) STAT1 and STAT2 heterodimers associate with the non-STAT DNA-binding protein, IFN gene regulatory factor-9 (IRF-9/p48/ISGF3-¦Ã)

Go back
1043.0, 711.0
17.0, 17.0

p100

p100

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004690 e80

MO000042106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c273 : 1
stoichiometry:c278 : 1
stoichiometry:c274 : 1

m567*m94*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1005.0, 833.0
21.0, 21.0

p101

p101

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016961 e81

MO000042108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c283 : 1
stoichiometry:c282 : 1

m1870*m95*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
935.0, 839.0
17.0, 17.0

p102

p102

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016961 e80

MO000042108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c279 : 1
stoichiometry:c284 : 1
stoichiometry:c280 : 1

m1870*m94*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
853.0, 1002.0
17.0, 17.0

p103

p103

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000047 MO000016665

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c285 : 1
stoichiometry:c287 : 1
stoichiometry:c286 : 1

m99*m1639*0.1

nodelay

--

true

0

false

PMID: 18163952, 12048245 Instead of Raf, MEKK1 was required for IFN-¦Ã-induced ERK activation and the induction IRF-9 gene

Go back
1500.0, 744.0
15.0, 15.0

p104

p104

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e85 e84

MO000000011

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c290 : 1
stoichiometry:c289 : 1

m101*m100*0.1

nodelay

--

true

0

false

PMID: 18163952, 12048245 Instead of Raf, MEKK1 was required for IFN-¦Ã-induced ERK activation and the induction IRF-9 gene

Go back
1062.5, 1382.0
19.0, 19.0

p105

p105

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e84

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c292 : 1
stoichiometry:c291 : 1

m100*0.1

nodelay

--

true

0

false

PMID: 18163952, 12048245 Instead of Raf, MEKK1 was required for IFN-¦Ã-induced ERK activation and the induction IRF-9 gene

Go back
730.0, 974.0
19.0, 19.0

p106

p106

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e84 MO000000078 MO000004676 MO000004670

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1
stoichiometry:c295 : 1
stoichiometry:c296 : 1
stoichiometry:c297 : 1

m100*m84*m554*m549*0.1

nodelay

--

true

0

false

PMID: 18163952, 10969079 This domain acts as a scaffold for the binding of MEK1 and ERK1/2, which permits the juxtaposition of the kinases and their activation.

Go back
533.0, 1068.5
14.5, 14.5

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000078 e84

MO000038670

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c300 : 1
stoichiometry:c299 : 1

m84*m100*0.1

nodelay

--

true

0

false

PMID: 18163952, 7624324 MEKK1 phosphorylates MEK1 on the same residue as does Raf

Go back
1192.0, 1155.5
16.5, 16.5

p108

p108

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e84

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c303 : 1
stoichiometry:c302 : 1

m39*m100*0.1

nodelay

--

true

0

false

PMID: 18163952, 10346818, 9689078, 10805784 MEKK1 is also required for the activation of NF-¦ÊB and c-Jun N-terminal kinases

Go back
1361.0, 709.0
21.0, 21.0

p109

p109

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e84

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c304 : 1
stoichiometry:c306 : 1
stoichiometry:c305 : 1

m97*m100*0.1

nodelay

--

true

0

false

PMID: 18163952, 10346818, 9689078, 10805784 MEKK1 is also required for the activation of NF-¦ÊB and c-Jun N-terminal kinases

Go back
891.0, 659.0
17.0, 17.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016845 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m1780*m11*0.1

nodelay

--

true

0

false

PMID: 18163952, 8417326 After being activated (i.e. tyrosyl phosphorylated) STAT1 and STAT2 heterodimers associate with the non-STAT DNA-binding protein, IFN gene regulatory factor-9 (IRF-9/p48/ISGF3-¦Ã)

Go back
817.0, 1393.0
21.0, 21.0

p110

p110

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e84

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c308 : 1
stoichiometry:c307 : 1

m100*0.1

nodelay

--

true

0

false

PMID: 18163952, 10747925 It also plays a major role in IFN-¦Â gene induction

Go back
1496.0, 908.0
23.0, 23.0

p111

p111

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016580 MO000000003

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c309 : 1
stoichiometry:c311 : 1
stoichiometry:c310 : 1

m1576*m80*0.1

nodelay

--

true

0

false

PMID: 18163952, 14759369 One recent study showed that Ras induces phosphorylation of C/EBP-¦Â and activated C/EBP-¦Â interacts with the transcriptional mediator complex

Go back
1116.0, 1644.0
15.0, 15.0

p112

p112

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e89 e47

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c312 : 1
stoichiometry:c314 : 1
stoichiometry:c313 : 1

m105*m63*0.1

nodelay

--

true

0

false

PMID: 18163952, 14759369 One recent study showed that Ras induces phosphorylation of C/EBP-¦Â and activated C/EBP-¦Â interacts with the transcriptional mediator complex

Go back
998.0, 1534.0
19.0, 19.0

p113

p113

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e48 e92 MO000016665

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c315 : 1
stoichiometry:c316 : 1
stoichiometry:c318 : 1
stoichiometry:c317 : 1

m64*m108*m1639*0.1

nodelay

--

true

0

false

PMID: 18163952, 12050152 GATE also binds another transcriptional activator, GBF1, in response to IFN-¦Ã

Go back
666.0, 338.0
19.0, 19.0

p114

p114

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016878 MO000016665

MO000080026

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c319 : 1
stoichiometry:c321 : 1
stoichiometry:c320 : 1

m1799*m1639*0.1

nodelay

--

true

0

false

PMID: 18163952, 10657627 CRKL is tyrosine phosphorylated during IFN-treatment

Go back
909.0, 1469.0
21.0, 21.0

p115

p115

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e92 e47 MO000016665

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c323 : 1
stoichiometry:c325 : 1
stoichiometry:c324 : 1

m108*m63*m1639*0.1

nodelay

--

true

0

false

PMID: 18163952 Mutation of this motif and/or interference with the ERK1/2 activation prevented the IFN-¦Ã-induced association between GBF1 and C/EBP-¦Â.

Go back
866.0, 1502.0
19.0, 19.0

p116

p116

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e94 e93

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c326 : 1
stoichiometry:c327 : 1
stoichiometry:c328 : 1

m110*m109*0.1

nodelay

--

true

0

false

PMID: 18163952, 15879117 Our subsequent studies have shown that GBF1 recruitment to the IRF-9 promoter is dependent on C/EBP-¦Â.

Go back
1409.0, 1658.0
21.0, 21.0

p117

p117

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000021 e97

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c329 : 1
stoichiometry:c331 : 1
stoichiometry:c330 : 1

m112*m114*0.1

nodelay

--

true

0

false

PMID: 18163952, 10799501 Signal induced binding of Cdc42/Rac to the CRIB causes MLK dimerization, leading to their autophosphorylation

Go back
1354.0, 1718.0
19.0, 19.0

p118

p118

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e96

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c332 : 1
stoichiometry:c333 : 1

m113*0.1

nodelay

--

true

0

false

PMID: 18163952, 10799501 Signal induced binding of Cdc42/Rac to the CRIB causes MLK dimerization, leading to their autophosphorylation

Go back
1302.0, 1658.0
19.0, 19.0

p119

p119

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c334 : 1
stoichiometry:c335 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18163952, 10799501 Signal induced binding of Cdc42/Rac to the CRIB causes MLK dimerization, leading to their autophosphorylation

Go back
951.0, 1239.0
17.0, 17.0

p12

p12

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e14 e13

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m14*m13*0.1

nodelay

--

true

0

false

PMID: 18163952 The resultant trimeric transcription factor, ISGF3, binds to the IFN-stimulated regulatory elements (ISREs) to induce the expression of many IFN-¦Á/¦Â-regulated genes.

Go back
1201.0, 1189.0
21.0, 21.0

p120

p120

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000058 e97

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c336 : 1
stoichiometry:c338 : 1
stoichiometry:c337 : 1

m39*m114*0.1

nodelay

--

true

0

false

PMID: 18163952, 9003778, 11432832 MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-¦ÊB

Go back
1423.0, 751.0
17.0, 17.0

p121

p121

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000023 e97

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c340 : 1
stoichiometry:c341 : 1
stoichiometry:c339 : 1

m97*m114*0.1

nodelay

--

true

0

false

PMID: 18163952, 9003778, 11432832 MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-¦ÊB

Go back
1301.0, 489.0
21.0, 21.0

p122

p122

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000016917 e97

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c342 : 1
stoichiometry:c344 : 1
stoichiometry:c343 : 1

m1832*m114*0.1

nodelay

--

true

0

false

PMID: 18163952, 9003778, 11432832 MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-¦ÊB

Go back
813.0, 807.5
18.5, 18.5

p123

p123

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000022 e97

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c345 : 1
stoichiometry:c347 : 1
stoichiometry:c346 : 1

m117*m114*0.1

nodelay

--

true

0

false

PMID: 18163952, 9003778, 11432832 MLKs function as MKKKs and have been implicated in the activation of JNK and SEK1 and transcription factor NF-¦ÊB

Go back
1097.0, 1393.0
21.0, 21.0

p124

p124

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665 MO000016913

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c349 : 1
stoichiometry:c350 : 1
stoichiometry:c348 : 1

m1639*m1828*0.1

nodelay

--

true

0

false

PMID: 18163952 co-expression of MLK3, but not MLK2, significantly stimulated the IFN-¦Ã-induced expression of IRF-9.

Go back
1638.0, 914.0
19.0, 19.0

p125

p125

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000016580 MO000017545 MO000016665

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c351 : 1
stoichiometry:c353 : 1
stoichiometry:c354 : 1
stoichiometry:c352 : 1

m1576*m2337*0.1

nodelay

--

true

0

false

PMID: 18163952, 15314150 One likely candidate is Cdk2, which phosphorylates C/EBP-¦Â in vitro at S64 and T189 PMID: 18163952, 8755534 IFN-¦Ã treatment has been shown to cause a decrease in Cdk2 activity

Go back
1539.0, 911.0
17.0, 17.0

p126

p126

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

MO000016580 MO000016665 MO000016913

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c355 : 1
stoichiometry:c357 : 1
stoichiometry:c358 : 1
stoichiometry:c356 : 1

m1576*0.1

nodelay

--

true

0

false

PMID: 18163952 IFN-¦Ã treatment decreased S64 phosphorylation. Surprisingly, MLK3 caused a decrease in phosphorylation of C/EBP-¦Â instead of its stimulation in an IFN-¦Ã dependent manner.

Go back
1045.0, 1285.0
21.0, 21.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 18163952 The resultant trimeric transcription factor, ISGF3, binds to the IFN-stimulated regulatory elements (ISREs) to induce the expression of many IFN-¦Á/¦Â-regulated genes.

Go back
1081.0, 125.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016835 MO000000145

MO000019460

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c41 : 1
stoichiometry:c40 : 1

m1772*m129*0.1

nodelay

--

true

0

false

PMID: 18163952 From fig.1

Go back
1230.0, 110.0
19.0, 19.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007500 MO000000146

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m881*m130*0.1

nodelay

--

true

0

false

PMID: 18163952 From fig.1

Go back
1321.0, 109.0
21.0, 21.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000019460

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m17*m4021*0.1

nodelay

--

true

0

false

PMID: 18163952 From fig.1

Go back
1398.0, 106.0
19.0, 19.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000016665

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m18*m1639*0.1

nodelay

--

true

0

false

PMID: 18163952 From fig.1

Go back
817.0, 377.0
21.0, 21.0

p18

p18

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e19

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c52 : 1

m1357*m19*0.1

nodelay

--

true

0

false

PMID: 18163952 Only the STAT1 protein is tyrosyl phosphorylated by JAK1 and JAK2 at the ligand engaged type II IFN receptor.

Go back
725.0, 505.0
21.0, 21.0

p19

p19

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000019704

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m4238*0.1

nodelay

--

true

0

false

PMID: 18163952, 7690989 STAT1 dimers, thus formed, migrate to the nucleus, bind to the ¦Ã-IFN-activated sequence (GAS) to drive ¦Ã-IFN-induced gene expression

Go back
677.0, 93.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007548 MO000000145

MO000038484

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c6 : 1
stoichiometry:c5 : 1

m901*m129*0.1

nodelay

--

true

0

false

PMID: 18163952 From fig.1

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728.0, 716.0
15.0, 15.0

p20

p20

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18163952, 7690989 STAT1 dimers, thus formed, migrate to the nucleus, bind to the ¦Ã-IFN-activated sequence (GAS) to drive ¦Ã-IFN-induced gene expression

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820.0, 1300.0
23.0, 23.0

p21

p21

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e22 e21

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m22*m21*0.1

nodelay

--

true

0

false

PMID: 18163952, 7690989 STAT1 dimers, thus formed, migrate to the nucleus, bind to the ¦Ã-IFN-activated sequence (GAS) to drive ¦Ã-IFN-induced gene expression

Go back
918.0, 1254.0
19.0, 19.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18163952, 7690989 STAT1 dimers, thus formed, migrate to the nucleus, bind to the ¦Ã-IFN-activated sequence (GAS) to drive ¦Ã-IFN-induced gene expression

Go back
329.0, 337.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e27 e26

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m27*m26*0.1

nodelay

--

true

0

false

PMID: 18163952, 15166220 The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5

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726.0, 354.0
19.0, 19.0

p24

p24

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e25

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m1357*m25*0.1

nodelay

--

true

0

false

PMID: 18163952, 15166220 The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5

Go back
986.0, 398.0
19.0, 19.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013120 e25

MO000016849

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m1358*m25*0.1

nodelay

--

true

0

false

PMID: 18163952, 15166220 The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5

Go back
516.0, 472.0
23.0, 23.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013122 e25

MO000021607

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c73 : 1

m1360*m25*0.1

nodelay

--

true

0

false

PMID: 18163952, 15166220 The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5

Go back
602.0, 542.0
19.0, 19.0

p27

p27

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017181 e25

MO000033720

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m2053*m25*0.1

nodelay

--

true

0

false

PMID: 18163952, 15166220 The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5

Go back
566.0, 694.0
19.0, 19.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016876 e25

MO000032346

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c80 : 1
stoichiometry:c79 : 1

m1798*m25*0.1

nodelay

--

true

0

false

PMID: 18163952, 15166220 The ligand-bound type III IFN receptor, although activated in a manner similar to the type I receptor, activates multiple STATs-STAT1, STAT2, STAT3, STAT4 and STAT5

Go back
1098.0, 482.0
19.0, 19.0

p29

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016958 e5

MO000038368

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c85 : 1
stoichiometry:c82 : 1

m1867*m5*0.1

nodelay

--

true

0

false

PMID: 18163952, 10878008, 10523304 some studies have shown p38¦Á is phosphorylated and activated in a type-I-IFN-dependent manner in several IFN-sensitive cell lines.

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773.0, 109.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000038484 MO000019457

MO000038483

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m16694*m4019*0.1

nodelay

--

true

0

false

--

Go back
1161.0, 473.0
21.0, 21.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016958 e12

MO000038368

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c86 : 1
stoichiometry:c84 : 1

m1867*m12*0.1

nodelay

--

true

0

false

PMID: 18163952, 10878008, 10523304 some studies have shown p38¦Á is phosphorylated and activated in a type-I-IFN-dependent manner in several IFN-sensitive cell lines.

Go back
1246.0, 382.0
19.0, 19.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030 e12

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c89 : 1
stoichiometry:c88 : 1

m28*m12*0.1

nodelay

--

true

0

false

PMID: 18163952, 15864272 The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation

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1202.0, 386.0
19.0, 19.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030 e5

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c91 : 1

m28*m5*0.1

nodelay

--

true

0

false

PMID: 18163952, 15864272 The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation

Go back
1149.0, 745.0
21.0, 21.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m45*m29*0.1

nodelay

--

true

0

false

PMID: 18163952, 15864272 The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation

Go back
1213.0, 925.0
21.0, 21.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017140 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m2018*m30*0.1

nodelay

--

true

0

false

PMID: 18163952, 15864272 The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation

Go back
1072.0, 1112.0
23.0, 23.0

p35

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e16 e30

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m16*m31*0.1

nodelay

--

true

0

false

PMID: 18163952, 15864272 The PI3K-signaling cascade also regulates IFN inducible activation of the mammalian target of rapamycin (mTOR), via Akt, which mediates the initiation of mRNA translation

Go back
1458.0, 1086.0
19.0, 19.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016580 MO000007384

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m1576*m871*0.1

nodelay

--

true

0

false

PMID: 18163952, 9238507 C/EBP-¦Â also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-¦Á (TNF-¦Á), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as ¦Á1-acid glycoprotein, ¦Á2-microglobulin, and C-reactive protein

Go back
1133.0, 1265.0
21.0, 21.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 9238507 C/EBP-¦Â also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-¦Á (TNF-¦Á), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as ¦Á1-acid glycoprotein, ¦Á2-microglobulin, and C-reactive protein

Go back
1190.0, 1382.0
19.0, 19.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 9238507 C/EBP-¦Â also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-¦Á (TNF-¦Á), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as ¦Á1-acid glycoprotein, ¦Á2-microglobulin, and C-reactive protein

Go back
1198.0, 1298.0
19.0, 19.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c106 : 1

m32*0.1

nodelay

--

true

0

false

--

Go back
865.0, 121.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000038483 e6

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m16693*m6*0.1

nodelay

--

true

0

false

PMID: 18163952 From fig.1

Go back
1170.0, 1350.0
19.0, 19.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 9238507 C/EBP-¦Â also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-¦Á (TNF-¦Á), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as ¦Á1-acid glycoprotein, ¦Á2-microglobulin, and C-reactive protein

Go back
1247.0, 1355.0
17.0, 17.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

G010291

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 9238507 C/EBP-¦Â also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-¦Á (TNF-¦Á), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as ¦Á1-acid glycoprotein, ¦Á2-microglobulin, and C-reactive protein

Go back
1270.0, 1430.0
19.0, 19.0

p42

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c114 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 9238507 C/EBP-¦Â also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-¦Á (TNF-¦Á), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as ¦Á1-acid glycoprotein, ¦Á2-microglobulin, and C-reactive protein

Go back
1100.0, 1248.0
23.0, 23.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c116 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 9238507 C/EBP-¦Â also regulates IL-6 and IL-6-induced expression of the cytokines IL-1, IL-8, tumor necrosis factor-¦Á (TNF-¦Á), and granulocyte colony-stimulating factor (G-CSF), as well acute phase response proteins such as ¦Á1-acid glycoprotein, ¦Á2-microglobulin, and C-reactive protein

Go back
1388.0, 1100.0
15.0, 15.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000013122

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m32*m1360*0.1

nodelay

--

true

0

false

PMID: 18163952, 8321203, 8552662, 9121452, 11238899 C/EBP-¦Â can interact with transcription factors outside its family, such as NF-¦ÊB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions.

Go back
1338.0, 1154.0
19.0, 19.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000000058

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m32*m39*0.1

nodelay

--

true

0

false

PMID: 18163952, 8321203, 8552662, 9121452, 11238899 C/EBP-¦Â can interact with transcription factors outside its family, such as NF-¦ÊB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions. PMID: 18163952, 7959007, 8756629, 8552662, 9121452 C/EBP-¦Â binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-¦ÊB, Sp1, Myb and PU.1

Go back
1657.0, 1209.0
21.0, 21.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000033284

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m32*m11975*0.1

nodelay

--

true

0

false

PMID: 18163952, 8321203, 8552662, 9121452, 11238899 C/EBP-¦Â can interact with transcription factors outside its family, such as NF-¦ÊB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions. PMID: 18163952, 7959007, 8756629, 8552662, 9121452 C/EBP-¦Â binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-¦ÊB, Sp1, Myb and PU.1

Go back
1350.0, 1130.0
19.0, 19.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000011894 e31

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m1320*m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 8321203, 8552662, 9121452, 11238899 C/EBP-¦Â can interact with transcription factors outside its family, such as NF-¦ÊB (84), retinoblastoma (pRb) tumor suppressor protein (85), Sp1 (86), STAT3 (87) to regulate cellular functions. PMID: 18163952, 7959007, 8756629, 8552662, 9121452 C/EBP-¦Â binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-¦ÊB, Sp1, Myb and PU.1

Go back
1640.0, 1000.0
23.0, 23.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m32*m43*0.1

nodelay

--

true

0

false

PMID: 18163952, 1934061 LIP dominantly inhibits the transcriptional activity of the full-length C/EBP-beta by dimerizing with it.

Go back
1659.0, 1147.0
17.0, 17.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m32*m46*0.1

nodelay

--

true

0

false

PMID: 18163952, 1547942 It can form heterodimers with C/EBP-¦Á and C/EBP-¦Â, and attenuate their transcriptional activity

Go back
953.0, 109.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016660 MO000038483

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m1636*m16693*0.1

nodelay

--

true

0

false

--

Go back
1418.0, 1382.0
19.0, 19.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000019417

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m46*m3982*0.1

nodelay

--

true

0

false

PMID: 18163952, 1547942 It can form heterodimers with C/EBP-¦Á and C/EBP-¦Â, and attenuate their transcriptional activity

Go back
686.0, 1418.0
19.0, 19.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000042409

G010787

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c139 : 1

m157177*0.1

nodelay

--

true

0

false

PMID: 18163952, 2112087 LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-¦Â

Go back
734.0, 1590.0
19.0, 19.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000006031

G010787

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c140 : 1

m740*0.1

nodelay

--

true

0

false

PMID: 18163952, 2112087 LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-¦Â

Go back
755.0, 1443.0
17.0, 17.0

p53

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007384

G010787

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c143 : 1

m871*0.1

nodelay

--

true

0

false

PMID: 18163952, 2112087 LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-¦Â

Go back
764.0, 1580.0
23.0, 23.0

p54

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000214

G010787

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c144 : 1

m185*0.1

nodelay

--

true

0

false

PMID: 18163952, 2112087 LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-¦Â

Go back
790.0, 1526.0
19.0, 19.0

p55

p55

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

G010787

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c148 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 18163952, 10777554 We have shown that IFN-¦Ã not only induces the expression of C/EBP-¦Â but also enhances its transcriptional activity

Go back
732.0, 1396.0
23.0, 23.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e46

G010787

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c147 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18163952, 2112087 LPS, IL-6, IL-1, dexamethasone, and glucagon can strongly up-regulate the expression of C/EBP-¦Â

Go back
1470.0, 930.0
19.0, 19.0

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016580 MO000000011

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c164 : 1
stoichiometry:c152 : 1

m1576*m66*0.1

nodelay

--

true

0

false

PMID: 18163952, 8336793, 8384717, 10635333, 11684016 Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells

Go back
1426.0, 930.0
19.0, 19.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016580 e63

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c166 : 1
stoichiometry:c154 : 1

m1576*m68*0.1

nodelay

--

true

0

false

PMID: 18163952, 8336793, 8384717, 10635333, 11684016 Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells

Go back
1382.0, 934.0
19.0, 19.0

p59

p59

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016580 MO000000051

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c165 : 1
stoichiometry:c156 : 1

m1576*m67*0.1

nodelay

--

true

0

false

PMID: 18163952, 8336793, 8384717, 10635333, 11684016 Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells

Go back
772.0, 372.0
23.0, 23.0

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e5

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m1357*m5*0.1

nodelay

--

true

0

false

PMID: 18163952, 9759489, 7532278, 9726434 The STAT1 and STAT2 proteins have been reported to be activated by the IFN-¦Á/¦Â via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.

Go back
1333.0, 933.0
21.0, 21.0

p60

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016580 MO000000104

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m1576*m92*0.1

nodelay

--

true

0

false

PMID: 18163952, 8336793, 8384717, 10635333, 11684016 Posttranscriptional modifications of C/EBP by protein kinases PKA, PKC,ribosomal S6 kinase (RSK), and extracellular signal-related kinase (ERK) appear to modulate its activity in different cells

Go back
1132.0, 1480.0
23.0, 23.0

p61

p61

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e48 e31

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m64*m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 10777554, 11312260 We have shown that C/EBP-¦Â binds to GATE and stimulates transcription

Go back
1133.0, 1573.0
21.0, 21.0

p62

p62

cso30:i:ME_Transcription

cso30:i:CC_Nucleoplasm

--

e49

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 18163952, 10777554, 11312260 We have shown that C/EBP-¦Â binds to GATE and stimulates transcription

Go back
1085.0, 982.0
17.0, 17.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000037579

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m32*m15836*0.1

nodelay

--

true

0

false

PMID: 18163952, 7959007, 8756629, 8552662, 9121452 C/EBP-¦Â binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-¦ÊB, Sp1, Myb and PU.1

Go back
1261.0, 953.0
21.0, 21.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000009617 e31

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m1158*m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 7959007, 8756629, 8552662, 9121452 C/EBP-¦Â binds to a variety of response elements and forms heteromeric complexes with other transcription factors, such as pRb, NF-¦ÊB, Sp1, Myb and PU.1

Go back
1098.0, 1430.0
19.0, 19.0

p65

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18163952, 11004486 IL-6 induces IRF-9 gene expression through GATE using C/EBP-¦Â

Go back
1214.0, 1478.0
19.0, 19.0

p66

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007384

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1

m871*0.1

nodelay

--

true

0

false

PMID: 18163952, 1888886 IL-6 induces the expression of 2-5A synthetase and MHC class I genes

Go back
1254.0, 1534.0
19.0, 19.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007384

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c177 : 1

m871*0.1

nodelay

--

true

0

false

PMID: 18163952, 1888886 IL-6 induces the expression of 2-5A synthetase and MHC class I genes

Go back
297.0, 769.0
21.0, 21.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e72 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c181 : 1
stoichiometry:c180 : 1

m77*m75*0.1

nodelay

--

true

0

false

--

Go back
490.0, 801.5
20.5, 20.5

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 MO000000012 MO000016777

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c185 : 1

m76*m78*m1720*0.1

nodelay

--

true

0

false

PMID: 18163952, 11057895 Ras activation is dependent on the recruitment of the adaptor proteins Grb and Sos to the growth factor receptors

Go back
867.0, 371.0
17.0, 17.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e12

MO000019704

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m1357*m12*0.1

nodelay

--

true

0

false

PMID: 18163952, 9759489, 7532278, 9726434 The STAT1 and STAT2 proteins have been reported to be activated by the IFN-¦Á/¦Â via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.

Go back
532.0, 871.5
16.5, 16.5

p70

p70

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 e73

MO000000003

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c188 : 1
stoichiometry:c187 : 1

m81*m79*0.1

nodelay

--

true

0

false

PMID: 18163952, 11057895 Ras activation is dependent on the recruitment of the adaptor proteins Grb and Sos to the growth factor receptors

Go back
529.0, 917.0
13.0, 13.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000009 MO000000003

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c191 : 1
stoichiometry:c190 : 1

m82*m80*0.1

nodelay

--

true

0

false

PMID: 18163952 Raf, a serine-threonine kinase, responds to Ras and phosphorylates MAP kinase kinase 1 (MEK1).

Go back
493.0, 1057.5
21.5, 21.5

p72

p72

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000078 e75

MO000038670

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c194 : 1
stoichiometry:c193 : 1

m84*m83*0.1

nodelay

--

true

0

false

PMID: 18163952 Raf, a serine-threonine kinase, responds to Ras and phosphorylates MAP kinase kinase 1 (MEK1).

Go back
497.0, 1177.0
21.0, 21.0

p73

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004670 MO000038670

MO000038672

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c197 : 1
stoichiometry:c196 : 1

m549*m16860*0.1

nodelay

--

true

0

false

PMID: 18163952 MEK1, a dual specificity kinase, phosphorylates at the conserved threonine and tyrosine residues present in the activation loop of ERKs: ERK1 (p44) and ERK2 (p42).

Go back
559.0, 1082.5
18.5, 18.5

p74

p74

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004676 MO000038670

MO000038692

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c200 : 1
stoichiometry:c199 : 1

m554*m16860*0.1

nodelay

--

true

0

false

PMID: 18163952 MEK1, a dual specificity kinase, phosphorylates at the conserved threonine and tyrosine residues present in the activation loop of ERKs: ERK1 (p44) and ERK2 (p42).

Go back
568.0, 1236.0
15.0, 15.0

p75

p75

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038672 MO000000038

MO000038364

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c203 : 1
stoichiometry:c204 : 1

m16862*m85*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
576.0, 1120.0
23.0, 23.0

p76

p76

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038692 MO000000038

MO000038364

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m16878*m85*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
514.0, 1310.0
19.0, 19.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038672 MO000000049

MO000038589

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m16862*m86*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
573.0, 1317.0
21.0, 21.0

p78

p78

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038692 MO000000049

MO000038589

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c211 : 1
stoichiometry:c212 : 1

m16878*m86*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
678.0, 1110.0
19.0, 19.0

p79

p79

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038692 MO000000279

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c215 : 1
stoichiometry:c217 : 1

m16878*m221*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
937.0, 381.0
21.0, 21.0

p8

p8

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013120 e5

MO000016849

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c27 : 1
stoichiometry:c23 : 1

m1358*m5*0.1

nodelay

--

true

0

false

PMID: 18163952, 9759489, 7532278, 9726434 The STAT1 and STAT2 proteins have been reported to be activated by the IFN-¦Á/¦Â via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.

Go back
742.0, 1110.0
19.0, 19.0

p80

p80

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038672 MO000000279

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c216 : 1
stoichiometry:c218 : 1

m16862*m221*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
673.0, 1289.0
21.0, 21.0

p81

p81

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038692 MO000017190

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c222 : 1
stoichiometry:c224 : 1

m16878*m2058*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
611.0, 1295.0
17.0, 17.0

p82

p82

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038672 MO000017190

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c221 : 1
stoichiometry:c223 : 1

m16862*m2058*0.1

nodelay

--

true

0

false

PMID: 18163952 ERKs1/2 are known to phosphorylate members of the AP1 family, such as Elk1, Egr1, Fos, and Jun.

Go back
570.0, 914.5
19.5, 19.5

p83

p83

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000009 MO000016660

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c227 : 1
stoichiometry:c226 : 1

m82*m1636*0.1

nodelay

--

true

0

false

PMID: 18163952, 9199317, 9668040 Raf activation by IFN-¦Ã and IFN-¦Â has been reported

Go back
614.0, 917.5
20.5, 20.5

p84

p84

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000009 MO000016665

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c230 : 1
stoichiometry:c229 : 1

m82*m1639*0.1

nodelay

--

true

0

false

PMID: 18163952, 9199317, 9668040 Raf activation by IFN-¦Ã and IFN-¦Â has been reported

Go back
1486.0, 346.0
19.0, 19.0

p85

p85

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017369 MO000000289

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c233 : 1
stoichiometry:c232 : 1

m2203*m230*0.1

nodelay

--

true

0

false

PMID: 18163952, 9305638 Rho and Rac, the G proteins similar to Ras, are activated first

Go back
1386.0, 322.0
19.0, 19.0

p86

p86

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000057 MO000000289

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c236 : 1
stoichiometry:c235 : 1

m89*m230*0.1

nodelay

--

true

0

false

PMID: 18163952, 9305638 Rho and Rac, the G proteins similar to Ras, are activated first

Go back
1342.0, 302.0
19.0, 19.0

p87

p87

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000057 MO000000214

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c239 : 1
stoichiometry:c238 : 1

m89*m185*0.1

nodelay

--

true

0

false

PMID: 18163952, 9305638 Rho and Rac, the G proteins similar to Ras, are activated first

Go back
1446.0, 350.0
19.0, 19.0

p88

p88

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000017369 MO000000214

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c242 : 1
stoichiometry:c241 : 1

m2203*m185*0.1

nodelay

--

true

0

false

--

Go back
1454.0, 542.0
19.0, 19.0

p89

p89

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000060 e69

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c245 : 1
stoichiometry:c244 : 1

m91*m74*0.1

nodelay

--

true

0

false

PMID: 18163952 These G-proteins then activate MAP kinase kinase kinases (MEKKs)

Go back
1038.0, 382.0
19.0, 19.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013120 e12

MO000016849

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m1358*m12*0.1

nodelay

--

true

0

false

PMID: 18163952, 9759489, 7532278, 9726434 The STAT1 and STAT2 proteins have been reported to be activated by the IFN-¦Á/¦Â via tyrosyl phosphorylation at critical residues, using tyrosine kinases Tyk2 and JAK1.

Go back
1410.0, 562.0
19.0, 19.0

p90

p90

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000060 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c248 : 1
stoichiometry:c247 : 1

m91*m90*0.1

nodelay

--

true

0

false

PMID: 18163952 These G-proteins then activate MAP kinase kinase kinases (MEKKs)

Go back
1336.0, 515.5
16.5, 16.5

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000016917 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c251 : 1
stoichiometry:c250 : 1

m1832*m93*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1491.0, 583.0
17.0, 17.0

p92

p92

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e79

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c254 : 1
stoichiometry:c253 : 1

m96*m93*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1414.0, 702.0
19.0, 19.0

p93

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e81

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c259 : 1
stoichiometry:c258 : 1

m97*m95*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1327.0, 695.0
17.0, 17.0

p94

p94

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000023 e80

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c260 : 1
stoichiometry:c256 : 1

m97*m94*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1194.0, 446.0
19.0, 19.0

p95

p95

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016958 e81

MO000038368

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c264 : 1
stoichiometry:c266 : 1
stoichiometry:c265 : 1

m1867*m95*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1055.0, 483.0
17.0, 17.0

p96

p96

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016958 e80

MO000038368

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c263 : 1
stoichiometry:c262 : 1

m1867*m94*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1042.0, 598.0
19.0, 19.0

p97

p97

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016959 e81

MO000038382

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c272 : 1
stoichiometry:c270 : 1

m1868*m95*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
967.0, 591.0
17.0, 17.0

p98

p98

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016959 e80

MO000038382

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c267 : 1
stoichiometry:c271 : 1
stoichiometry:c268 : 1

m1868*m94*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
1101.0, 717.0
21.0, 21.0

p99

p99

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000004690 e81

MO000042106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c275 : 1
stoichiometry:c277 : 1
stoichiometry:c276 : 1

m567*m95*0.1

nodelay

--

true

0

false

PMID: 18163952 MEKKs then activate stress responsive kinases, such as the various isoforms of p38 MAPK (¦Á, ¦Â, ¦Ã, ¦Ä) and c-Jun N-terminal kinases (JNK), using the intermediate enzymes SEK1/2.

Go back
499.0, 128.90697358120494

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
819.0, 148.19625702069314

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.1676940130167, 1020.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1468.0, 1046.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1468.0, 1105.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1484.997733389953, 1092.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1161.558689587989, 1169.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1154.0, 1284.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1208.0, 1317.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1224.0016031360567, 1172.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1195.6177335302002, 1174.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1167.0, 1360.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
876.0, 67.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1269.8229000641898, 1177.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1257.0, 1372.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1215.098584350072, 1176.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1200.0, 1401.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1280.0, 1449.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1291.492011346698, 1178.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1109.6930369309187, 1271.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1130.7256017206098, 1168.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1409.2948273388472, 1117.937119481449

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 421.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
877.0, 142.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1399.0, 1067.295372041401

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1365.0, 1164.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1288.0, 1164.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1352.0, 1173.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1482.0, 1168.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1515.0, 1220.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1507.4728815779588, 1224.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1315.0, 1125.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.80732922741, 1143.7451677096565

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1360.0, 1021.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.6568542494924, 88.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1482.0, 1027.082916536019

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1515.0, 1015.5084479102155

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1526.4262408218644, 875.8784275570199

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1482.0, 1156.3161370509245

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1508.0, 1170.0668293397994

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1508.3928717759818, 1164.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1444.0492821445084, 1365.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1375.0, 1395.2854048166537

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1428.0, 1401.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
698.0, 1437.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 131.16949170672916

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.4941633431785, 1533.601259712544

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
278.0, 1430.1639519239586

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.0, 1600.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
732.0570138197744, 1460.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.7618204050059, 1532.428457546758

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.422524508706, 1098.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
776.0, 1611.0

c146

c146

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
722.055209250746, 1419.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.6970138105231, 1518.1808205796483

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
338.0, 1408.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
964.0, 130.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
807.0251227921447, 62.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1470.0, 956.9328032894898

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1407.262635093008, 857.0253358311252

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1441.62816499953, 956.5559743736493

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1400.2405150182822, 858.3143053269799

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1405.2216722050282, 959.0608695236934

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1392.0, 859.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1360.5230638769622, 955.6313753526432

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1349.0, 858.2584848522703

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1253.0, 750.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
800.4829175920399, 338.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 1489.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 1503.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1160.6191431379104, 1178.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 1545.0

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1481.3897804297073, 807.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1343.0, 850.0

c165

c165

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1436.0, 841.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1109.259444020721, 998.3616175436862

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.5601767747798, 1004.7519070083929

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 943.7409381791748

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.0, 395.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1266.0, 981.9510698773889

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1287.591463582408, 979.7214976192082

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1278.0, 942.1554175279994

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1123.3521865935584, 1175.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1038.0, 1440.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1238.9234223527205, 1106.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1224.0, 1497.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1211.427813527082, 1522.9711254108329

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1278.271029555967, 1107.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
325.6647816700008, 748.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.2664073870042, 234.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
318.0, 783.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
195.0, 780.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 812.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 761.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
517.4698886744255, 773.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.7710985682476, 821.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.1659646153463, 840.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.0740528189224, 887.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
440.0, 880.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
547.3005910576243, 865.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0, 338.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.17723087710823, 930.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 924.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
516.7053735814004, 1036.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 1079.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.0, 996.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
519.5536798306425, 1151.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 1198.0

c196

c196

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
505.0, 1131.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 1004.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
578.0, 1078.8308170454445

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.1867236234419, 128.91149082294638

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.4376015698018, 388.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.0, 1097.808987532707

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 1244.0

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
595.8089875327071, 1080.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
570.0, 1189.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.0, 1219.0918708781414

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
575.0, 1150.3730830011045

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.0, 1143.0

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
514.0, 1259.0

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
585.8724030988352, 1080.0

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
534.2719439311038, 1291.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.8274221254213, 226.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 1329.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.0, 1291.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.2639240088533, 1338.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.0, 1076.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 1128.6699855270836

c214

c214

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
696.3636881022716, 1069.0

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.0, 1069.0

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 1129.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.1348965210016, 1129.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
527.0, 1252.0

c219

c219

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
960.5174713247359, 343.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
616.0, 1080.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.197769023179, 1267.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0, 1267.0

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 1312.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.2950039375453, 1310.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
583.8669836198026, 865.0

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
510.37673718523206, 932.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.6156267921539, 88.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
599.0, 865.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.2578708076567, 933.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.0, 402.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
638.3231332361153, 62.0

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1496.0, 301.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1496.0, 365.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1512.645448200392, 288.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1396.0, 294.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1374.367306591753, 341.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1412.9175464491118, 286.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1367.509867769654, 290.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1353.0, 321.0

c238

c238

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 328.5294021250751

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1005.0, 343.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1464.7497264551948, 301.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1462.0, 369.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 376.3312316314695

c242

c242

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1451.0, 498.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1452.7523067384539, 561.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1467.8561812775845, 433.0

c245

c245

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1425.4941633431786, 498.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1425.0, 581.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1361.0, 390.0

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1344.0, 476.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.1214751973158, 401.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1336.4310835055999, 532.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1357.7612613779334, 537.5504835226432

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1503.4743082804014, 551.0

c252

c252

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1501.0, 600.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1462.0, 601.2189028942252

c254

c254

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1344.9691115068547, 667.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1339.0, 712.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1381.0, 667.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1381.5172413793102, 721.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1439.4698886744254, 658.0

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
974.0, 226.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1333.0, 608.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1077.8223117743428, 435.0

c261

c261

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.0, 498.0

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1079.495671173103, 497.79551670800146

c263

c263

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1156.0, 429.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1152.437601569802, 465.0

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1219.7278987396185, 466.32843834996424

c266

c266

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.1676940130167, 575.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
982.0, 608.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1034.0, 577.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 234.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1035.4844874248342, 617.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
991.9976784677399, 592.0

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1068.963471830794, 609.7636205865145

c272

c272

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1063.7736221307564, 672.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.0, 728.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1103.0, 672.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1090.603947249397, 738.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.8579778489789, 654.0

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1067.2761028340642, 599.0

c278

c278

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
954.1518250739341, 811.0

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.0, 458.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
949.0, 856.0

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 811.0

c281

c281

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.7053735814004, 854.0

c282

c282

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.4557415194017, 656.0

c283

c283

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
958.6788990825688, 603.0

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
831.0, 959.0

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
834.3999245561242, 1019.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.9459683861535, 62.0

c287

c287

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1483.0, 736.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1496.352465419694, 759.0

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.8843911260781, 467.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 759.4069004724233

c290

c290

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1031.1192895849365, 1400.0

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.0, 1091.0

c292

c292

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
753.2360065580478, 999.0484903342966

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 987.5523407378585

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.0, 984.2206057307866

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.0, 996.9066358085903

c296

c296

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 944.0

c297

c297

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.0, 1036.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.3149107106393, 1083.0

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.0, 121.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
900.0, 489.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 1076.0

c300

c300

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1217.0, 1164.0

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1159.7611400011626, 1166.0

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0, 1079.0

c303

c303

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1367.0, 667.0

c304

c304

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1364.6600336668405, 730.0

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
835.0, 731.333811395275

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
801.8174109113824, 1397.6994371546484

c307

c307

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.0, 1091.0

c308

c308

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1473.0, 938.5358930107922

c309

c309

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 588.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1412.588060808082, 854.538441890012

c310

c310

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 920.0322578022757

c311

c311

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1068.0, 1652.0

c312

c312

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1124.0, 1659.0

c313

c313

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1129.5010562068608, 851.0

c314

c314

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.8528636811963, 1495.0

c315

c315

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.0, 1503.0

c316

c316

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 1553.0

c317

c317

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.0635888342409, 62.0

c318

c318

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
633.0, 323.0

c319

c319

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 668.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.0, 357.0

c320

c320

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.4045419973735, 54.0

c321

c321

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.9089506987169, 1483.2035359758918

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.7498550481392, 851.0

c323

c323

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
920.0, 1441.0

c324

c324

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.578213009808, 62.0

c325

c325

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
858.0, 1462.0

c326

c326

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.451643978432, 1433.0

c327

c327

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.0641201816035, 1521.0

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1437.9969153652216, 1668.0

c329

c329

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 676.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1420.0, 1679.0

c330

c330

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1420.0, 1605.0

c331

c331

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1381.0, 1728.0

c332

c332

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1315.0, 1728.0

c333

c333

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1300.0, 1684.718110569902

c334

c334

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1318.0, 1630.895473721262

c335

c335

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1228.895473721262, 1174.0

c336

c336

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1159.7324924628942, 1186.0514775921965

c337

c337

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.7799450980763, 1217.050674794339

c338

c338

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1383.7104889620337, 762.0

c339

c339

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
898.0, 1248.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.0, 667.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1420.0, 775.9991046335188

c341

c341

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1324.8776860867974, 476.0

c342

c342

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1314.0, 510.0

c343

c343

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1313.788593352494, 517.9610376537486

c344

c344

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.43180206412, 771.0

c345

c345

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.0, 826.0

c346

c346

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.9074305606983, 832.3180001022415

c347

c347

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1037.4581244641497, 1408.0

c348

c348

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1111.7310940842465, 62.0

c349

c349

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
968.0, 1248.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.5525237496204, 1410.6380646336702

c350

c350

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1482.0, 934.1288776358441

c351

c351

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1413.6024722224167, 847.4904650383779

c352

c352

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
968.0, 927.2616246408636

c353

c353

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1412.0, 62.0

c354

c354

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1478.0, 934.51964259655

c355

c355

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1413.122995094307, 850.6418320782923

c356

c356

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1410.0, 62.0

c357

c357

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1485.0, 931.9786022089314

c358

c358

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
902.0, 777.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1036.0, 1257.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1057.0, 1306.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1066.0, 153.34568970296988

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 121.53589301079212

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1096.0, 146.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.0, 142.75461947900664

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1195.0, 135.94594513699568

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1240.0, 137.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1244.0, 129.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1288.0, 137.0118113439882

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1139.0, 128.35246541969397

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1333.0, 130.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1351.0, 131.61541201655623

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1408.0, 62.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 114.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1408.0, 125.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.4133125023502, 338.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 398.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
845.6716320271622, 220.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.5631853341599, 463.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 526.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 624.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.0, 731.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
791.0, 1324.218902894225

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 1314.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 122.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
818.0, 1284.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.0, 1279.8458558686448

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 1269.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 348.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.5559743736493, 313.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.0, 351.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.4404159196479, 329.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 373.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 365.4236471494396

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
993.0, 343.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 137.00593110994228

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.2350150421889, 417.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 381.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
536.0769230769231, 424.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.5909734841225, 495.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 394.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.0, 503.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 561.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
462.0, 391.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
540.0, 659.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.0, 704.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
585.0, 128.1654982908955

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.0, 400.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1115.322338796717, 436.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1113.0, 501.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1148.0, 436.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.322338796717, 494.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.0, 234.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
979.0, 226.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1245.0, 355.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.0, 401.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
982.0, 221.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
787.0, 130.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1220.4844874248342, 355.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1218.0, 405.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
902.0, 228.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1157.0, 723.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1160.0, 766.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1166.5211269273004, 483.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1224.0, 878.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1224.0, 946.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1167.0, 823.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1065.0, 1142.9696336681488

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back