1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18178131.csml convertedTime:2009.07.01.11:13

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Is HIV infection a TNF receptor signalling-driven disease?
Authors Herbein G, Khan KA.
Affiliation Department of Virology, EA3186, IFR133, Franche-Comte University, HopitalSaint-Jacques, Besancon Cedex, France. gherbein@chu-besancon.fr
Abstract Recent studies indicate that TNF (tumor necrosis factor) receptor signalling isa key player in HIV infection. HIV proteins have been shown to target TNFreceptor signalling, leading both to apoptosis of uninfected bystander T cellsand to sustained viral replication in infected T cells and macrophages. Thisarticle proposes a model that highlights the role of HIV proteins in themodulation of TNF receptor signalling and could explain both immune suppressionand the formation of viral reservoirs during HIV infection.
PMID 18178131
Model Abstract

Entity

MO000000058:NF-kappaB{active} MO000016962:TRAF1 MO000016985:Cytochrome C MO000017052:Bcl-2 family MO000017157:CXCR4 MO000018835:Vpu e1: e10: e100: e101: e102: e103: e104: e105:PI3K e106:AKT e107:Nef:AKT:PI3K e108:TRAIL e109:PKC e11:TNF-alpha:TNFR1 e110:PKC{active} e111:gp120{p}:CD4 e112:Elk-1 e113:Elk-1{active} e114:Proinflammatory cytokine e115:CXCR4:gp120 e116:caspase e117:caspase{active} e118:Cytochrome C e119: e12:TNFR2 e120: e121: e122: e123: e124: e125:TNFR1:TRAF1 e126:TNFR2:TRAF1 e127:PD-1 e13:TNF-alpha:TNFR2 e14:Nef e15:NF-kappaB e16:AP-1 e17:AP-1{active} e18:ERK1 e19:ERK1{p} e2: e20:JNK e21:JNK{p} e22:ERK2 e23:ERK2{p} e24:p38 e25:p38{p} e26:IRF-3 e27:IRF-3{p} e28:IKK e29:IKK{p} e3: e30:MAPK e31:MAPK{active} e32:Vpr e33:Sp1 e34:Vpr:Sp1 e35:TFIIB e36:Vpr:TFIIB e37:p300 e38:p300{active} e39:ERK e4: e40:ERK{active} e41:JNK{active} e42:Tat e43:Vpar:Tat e44:p38{active} e45:ERK1{active} e46:ERK2{active} e47:SAPK e48:SAPK{active} e49:ASK-1 e5:TNF-alpha e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TNFR1 e60: e61: e62: e63:Nef:ASK-1 e64:ASK-1{active} e65:caspase-3 e66:caspase-3{active} e67:Caspas-8 e68:Caspas-8{active} e69:PI3K e7: e70:Nef:PI3K e71:Nef:PI3K{active} e72:Bad e73:Bad{p] e74:Bad{inactive} e75:PAK2 e76:Nef2:PAK2 e77:p53 e78:Nef:p53 e79:Nef e8: e80:p53 e81:Nef:p53 e82:Bcl-2 e83:TRAIL-DR5 e84:Fas-Fas e85:Fas-Fas:TRAIL-DR5 e86:TRAF2 e87:degradants e88:cIAP e89:TNF-alpha:TNFR1:cIAP e9: e90:gp120 e91:TNF-alpha e92:C-C-chemokines e93:C-C-chemokines e94:CD4 e95:gp120:CD4 e96: e97: e98: e99:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p8 p9
Model Detail
829.0, 953.0
22.0, 22.0

NF-kappaB{active}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3 p11 p12 p18 p22 p24 p47 p56 p62

p59 p66

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false

--

Go back
230.0, 510.0
20.0, 20.0

TRAF1

--

MO000016962

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71 p72

true true true true

csml-variable:Double

m1871

10

false

infinite

0

unit false false false
InterProIPR002083
TRANSPATHMO000016962

--

Go back
264.0, 928.0
24.0, 24.0

Cytochrome C

--

MO000016985

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70 p75

true true true true

csml-variable:Double

m1889

10

false

infinite

0

unit false false false
InterProIPR002327
TRANSPATHMO000016985

--

Go back
327.0, 1419.0
18.0, 18.0

Bcl-2 family

--

MO000017052

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75

true true true true

csml-variable:Double

m1946

10

false

infinite

0

unit false false false
TRANSPATHMO000017052

--

Go back
157.0, 1177.0
22.0, 22.0

CXCR4

--

MO000017157

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p69

true true true true

csml-variable:Double

m2033

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017157

--

Go back
501.0, 1589.0
22.0, 22.0

Vpu

--

MO000018835

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50 p71 p72

true true true true

csml-variable:Double

m3457

10

false

infinite

0

unit false false false
TRANSPATHMO000018835

--

Go back
104.88618834984436, 229.49875798392566
1133.3180594822638, 1645.5778223682466

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
126.80562894261246, 251.65065302311936
1098.5322516393844, 1545.3259877378714

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
219.57455538221495, 819.1027535101404
104.40736349453962, 145.78833073322912

--

e100

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false true false

--

Go back
219.2562402496095, 818.7844383775351
105.04399375975021, 146.42496099843973

--

e101

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false true false

--

Go back
232.30716068642687, 830.0846255850234
78.94215288611537, 123.82458658346322

--

e102

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false true false

--

Go back
232.62547581903232, 830.4029407176287
78.30552262090478, 123.18795631825259

--

e103

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false true false

--

Go back
232.62547581903232, 830.4029407176287
78.30552262090478, 123.18795631825259

--

e104

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false true false

--

Go back
1063.0, 967.5
26.939021936003222, 16.61239686053532

PI3K

--

e105

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1072.0, 915.5
23.519999999999996, 17.639999999999997

AKT

--

e106

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1028.5, 1016.0
23.50045879977978, 32.791337860157824

Nef:AKT:PI3K

--

e107

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
819.5, 174.0
16.94002817468303, 27.470315958945452

TRAIL

--

e108

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p51

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
433.0, 1480.0
14.17960710944808, 32.72217025257249

PKC

--

e109

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
380.5, 230.0
22.25257618943214, 43.06950230212673

TNF-alpha:TNFR1

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p12 p13 p14 p46 p47 p74

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
377.0, 1476.0
14.17960710944808, 32.72217025257249

PKC{active}

--

e110

cso30:c:Protein

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
237.5, 1543.0
21.638060323279454, 26.495584069321783

gp120{p}:CD4

--

e111

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
500.0, 1075.5
23.52, 17.640000000000004

Elk-1

--

e112

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p58 p63

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
520.0, 1139.5
23.52, 17.640000000000004

Elk-1{active}

--

e113

cso30:c:Protein

cso30:i:CC_Cytosol

--

p58 p63

p60 p65

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
818.0, 1348.0
60.0, 32.0

Proinflammatory cytokine

--

e114

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p59 p60 p61

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
156.5, 1223.0
22.001096250822187, 42.58276693707519

CXCR4:gp120

--

e115

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

p70 p68

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
337.0, 1654.5
29.607566914872212, 18.25799959750453

caspase

--

e116

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p68

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
597.0, 1546.5
29.607566914872212, 18.25799959750453

caspase{active}

--

e117

cso30:c:Protein

cso30:i:CC_Cytosol

--

p68

p51

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
372.0, 940.0
24.0, 24.0

Cytochrome C

--

e118

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70 p75

p76

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
InterProIPR002327
TRANSPATHMO000016985

--

Go back
236.08581856248293, 1265.8572643216462
223.39102570175584, 67.5201170931352

--

e119

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false true false

--

Go back
467.5, 244.0
25.42882249560633, 39.121265377855885

TNFR2

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2 p51 p72

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
240.03646371154935, 1269.8079094707127
215.48973540362311, 59.61882679500228

--

e120

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false true false

--

Go back
236.08581856248293, 1265.8572643216462
223.39102570175584, 67.5201170931352

--

e121

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false true false

--

Go back
238.2407159165191, 1268.0121616756824
219.08123099368356, 63.21032238506266

--

e122

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false true false

--

Go back
239.3181645935374, 1269.0896103527004
216.9263336396472, 61.05542503102648

--

e123

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false true false

--

Go back
236.08581856248293, 1265.8572643216462
223.39102570175584, 67.5201170931352

--

e124

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false true false

--

Go back
153.5, 439.0
21.30103047577286, 41.22780092085069

TNFR1:TRAF1

--

e125

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p71

--

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
159.5, 564.0
24.48870861653146, 47.39750054812541

TNFR2:TRAF1

--

e126

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p72

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
780.0, 1469.0
55.7439446366782, 29.730103806228374

PD-1

--

e127

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p73 p74

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
556.5, 231.0
22.069063801797853, 42.71431703573777

TNF-alpha:TNFR2

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p45 p73

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
766.0, 433.5
28.04990943851883, 17.297444153753275

Nef

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3 p4 p5 p6 p7 p8 p9 p10 p32 p34 p35 p36 p40 p41 p52

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
653.0, 953.0
22.0, 22.0

NF-kappaB

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p11 p12 p18 p22 p24 p47 p56 p62

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false

--

Go back
823.5, 618.0
17.252767156369494, 27.977460253572147

AP-1

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4 p13 p21 p25 p57 p64

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
863.5, 690.0
17.252767156369494, 27.977460253572147

AP-1{active}

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

p4 p13 p21 p25 p57 p64

p61 p67

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
962.0, 455.5
28.267256993358828, 17.431475145904614

ERK1

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5 p29

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
865.0, 504.0
30.36585365853658, 24.29268292682927

ERK1{p}

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
104.88618834984436, 229.49875798392566
1133.3180594822638, 1645.5778223682466

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
665.0, 610.5
30.9961762930167, 19.114308714026972

JNK

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6 p20 p27

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
736.0, 603.0
31.951219512195117, 25.5609756097561

JNK{p}

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
985.0, 510.5
29.57134232239887, 18.235661098812642

ERK2

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7 p30

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
913.0, 568.0
29.999999999999993, 23.999999999999993

ERK2{p}

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
589.0, 434.5
30.235459851076662, 18.645200241497285

p38

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8 p28

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
608.0, 483.0
32.56097560975609, 26.048780487804887

p38{p}

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
557.0, 502.5
30.947876836385586, 19.08452404910445

IRF-3

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
560.0, 555.0
32.19512195121952, 25.756097560975608

IRF-3{p}

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
512.0, 601.5
32.95230428657677, 20.32058764338901

IKK

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
595.0, 675.0
33.292682926829265, 26.634146341463413

IKK{p}

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
127.5525495394898, 252.16511917357104
1087.9853371029737, 1600.2450999889572

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
334.0, 653.5
28.480000000000008, 21.36

MAPK

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14 p26 p19

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
394.0, 617.5
28.480000000000008, 21.36

MAPK{active}

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p14 p26 p19

p62 p63 p64

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
902.0, 623.5
28.267256993358824, 17.43147514590461

Vpr

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15 p16 p17 p20 p21 p22 p23

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1011.0, 634.5
25.279999999999998, 18.96

Sp1

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
968.5, 682.0
22.511748041993002, 27.565405765705716

Vpr:Sp1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1023.5, 483.0
16.582612195612803, 26.89072247937211

TFIIB

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1100.5, 650.0
22.381103149475088, 27.405432427928673

Vpr:TFIIB

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
845.0, 735.0
14.945743685687559, 34.49017773620206

p300

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
933.0, 811.0
14.945743685687559, 34.49017773620206

p300{active}

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

p17

p18

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
227.0, 1037.5
34.90843228013684, 21.526866572751054

ERK

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p55

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
169.48531774033356, 291.83125125544996
1004.1198007012864, 1520.9128358251965

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
287.0, 1073.5
34.90843228013684, 21.526866572751054

ERK{active}

--

e40

cso30:c:Protein

cso30:i:CC_Cytosol

--

p55

p56 p57 p58

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
685.0, 662.5
30.9961762930167, 19.114308714026972

JNK{active}

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20 p27

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
984.0, 810.5
24.639999999999997, 18.479999999999993

Tat

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23 p24 p25 p26 p27 p28 p29 p30 p31 p43

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1084.5, 758.0
22.332111314780864, 27.34544242626228

Vpar:Tat

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
593.0, 366.5
30.235459851076662, 18.645200241497285

p38{active}

--

e44

cso30:c:Protein

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
990.0, 411.5
28.267256993358828, 17.431475145904614

ERK1{active}

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1117.0, 486.5
29.57134232239887, 18.235661098812642

ERK2{active}

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

p30

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1140.0, 786.0
16.00374181478017, 36.93171188026192

SAPK

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1120.0, 878.0
16.00374181478017, 36.93171188026192

SAPK{active}

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
706.0, 359.5
27.21674381163211, 16.783658683839803

ASK-1

--

e49

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32 p33

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
362.0, 183.5
27.035620849265445, 16.671966190380356

TNF-alpha

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

p48

p1 p2

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
509.7829892515675, 1085.5015055991353
509.100244018544, 461.69798666113763

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
564.7696077861588, 1096.4430766797075
297.68617620451164, 447.47730945391584

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
516.4193052816045, 1091.6637990555987
495.82761195847047, 449.3733997482117

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
517.3673504287525, 1092.6118442027469
493.93152166417383, 447.47730945391584

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
509.7829892515675, 1085.5015055991353
509.100244018544, 461.69798666113763

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
509.7829892515675, 1085.5015055991353
509.100244018544, 461.69798666113763

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
517.3673504287525, 1092.6118442027469
493.93152166417383, 447.47730945391584

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
881.416686933633, 1275.110535028761
31.80578599291386, 28.792606267269406

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
797.988713984599, 1407.836855629498
90.06428897907197, 81.53188265473892

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
509.7829892515675, 1085.5015055991353
509.100244018544, 461.69798666113763

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
279.5, 244.0
25.42882249560633, 39.121265377855885

TNFR1

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1 p71

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
629.7750522568342, 1290.676275829475
16.12245668383615, 7.762664329254457

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
629.2366777922321, 1267.5261738515758
55.18338262173526, 99.33008871912344

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
652.386779770131, 1332.1311096038512
8.613991433636713, 8.61399143363671

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
836.5, 314.0
22.79753374437594, 27.915347442092983

Nef:ASK-1

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33 p51

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
450.0, 395.5
27.21674381163211, 16.783658683839803

ASK-1{active}

--

e64

cso30:c:Protein

cso30:i:CC_Cytosol

--

p33

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
311.5, 434.0
16.999597504528076, 27.56691487220769

caspase-3

--

e65

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34 p76

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
303.5, 546.0
16.999597504528076, 27.56691487220769

caspase-3{active}

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

p34 p76

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
934.5, 333.0
18.533507748037835, 30.054336888710004

Caspas-8

--

e67

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
1042.5, 365.0
18.533507748037835, 30.054336888710004

Caspas-8{active}

--

e68

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35

p75

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
464.0, 670.0
15.188961646398502, 35.05144995322732

PI3K

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
145.7763346127098, 225.1206932293309
1111.4319326173102, 1574.8703399448227

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
516.5, 766.0
23.009831694717548, 28.17530411598067

Nef:PI3K

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
316.5, 766.0
23.009831694717548, 28.17530411598067

Nef:PI3K{active}

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
290.0, 895.5
27.156369490843225, 16.74642785268666

Bad

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
429.0, 940.0
29.878048780487802, 23.90243902439024

Bad{p]

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
518.0, 939.5
27.156369490843225, 16.74642785268666

Bad{inactive}

--

e74

cso30:c:Protein

cso30:i:CC_Cytosol

--

p39

p51

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
558.0, 719.5
28.508754276514388, 17.580398470517206

PAK2

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
545.5, 831.0
20.976670554907514, 25.685719046825533

Nef2:PAK2

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
357.0, 550.5
29.945663111289992, 18.466492251962162

p53

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
278.5, 616.0
26.300449925012497, 32.2046325612398

Nef:p53

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
606.0, 1183.5
28.04990943851883, 17.297444153753275

Nef

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
149.74704028280752, 252.91563292001362
1066.2098965274765, 1548.1367697578964

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
773.0, 1178.5
29.945663111289992, 18.466492251962162

p53

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p42

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
682.5, 1252.0
26.300449925012497, 32.2046325612398

Nef:p53

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
838.0, 1232.0
60.0, 32.0

Bcl-2

--

e82

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p43

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
1204.5, 1034.0
23.852372583479784, 36.69595782073814

TRAIL-DR5

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p44

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1281.0, 1042.5
30.102636345341118, 18.56329241296035

Fas-Fas

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p44

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1201.5, 1107.0
21.56610392457794, 41.74084630563473

Fas-Fas:TRAIL-DR5

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
226.0, 325.5
27.83999999999999, 20.879999999999992

TRAF2

--

e86

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p45 p46

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
296.0, 712.0
23.917288914417, 23.120045950603096

degradants

--

e87

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
238.5, 401.0
18.123968605353184, 29.390219360032198

cIAP

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p46

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
152.5, 352.0
23.216369976142406, 32.39493485043127

TNF-alpha:TNFR1:cIAP

--

e89

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p46

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
160.33558873640058, 280.71057261069586
1061.34206349703, 1527.8333439504956

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
376.0, 1258.0
15.797006548175865, 36.45463049579045

gp120

--

e90

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p48 p49 p50 p69

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
578.0, 1276.0
60.0, 32.0

TNF-alpha

--

e91

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p48

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
626.0, 1384.0
60.0, 32.0

C-C-chemokines

--

e92

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p65 p66 p67

p49

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
82.5, 1340.0
19.79935600724492, 32.1070637955323

C-C-chemokines

--

e93

cso30:c:Protein

cso30:i:CC_Extracellular

--

p49

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
348.0, 1194.5
24.32, 18.240000000000002

CD4

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
289.5, 1251.0
21.638060323279454, 26.495584069321783

gp120:CD4

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p53 p54 p19 p55

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
258.56815912636443, 889.6891341653666
9.038948576810986, 16.270107438259732

--

e96

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false true false

--

Go back
262.27192342125284, 900.1831330008836
1.4109578266241518, 1.4109578266241514

--

e97

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false true false

--

Go back
219.57455538221495, 819.1027535101404
104.40736349453962, 145.78833073322912

--

e98

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false true false

--

Go back
219.57455538221495, 819.1027535101404
104.40736349453962, 145.78833073322912

--

e99

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false true false

--

Go back
281.0, 181.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e5

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m5*0.1

nodelay

--

true

0

false

PMID: 18178131 TNF binds to the cell transmembrane receptors TNFR1 and TNFR2, mainly to modulate immunity PMID: 18178131 TNFalpha binds to two distinct cell transmembrane receptors, 55 kDa TNFR1 (also called TNF R55, TNF Rbeta, p55, or CD120a) and 75 kDa TNFR2 (also called TNF R75, TNF Ralpha, p75, and CD120b).

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621.0, 617.0
21.0, 21.0

p5

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e28 e14

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m29*m14*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

Go back
713.0, 681.0
21.0, 21.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e29 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m30*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

Go back
386.0, 498.0
20.0, 20.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m11*m16*0.1

nodelay

--

true

0

false

PMID: 18178131 Both exogenous Nef and TNF activate NF-KappaB, AP-1, and MAPK, suggesting that they might modulate the cellular machinery in a similar way, and therefore might have the same effect on HIV-1 replication in mononuclear phagocytes.

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462.0, 454.0
20.0, 20.0

p12

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m11*m17*0.1

nodelay

--

true

0

false

PMID: 18178131 Both exogenous Nef and TNF activate NF-KappaB, AP-1, and MAPK, suggesting that they might modulate the cellular machinery in a similar way, and therefore might have the same effect on HIV-1 replication in mononuclear phagocytes.

Go back
514.0, 442.0
20.0, 20.0

p12

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m11*m31*0.1

nodelay

--

true

0

false

PMID: 18178131 Both exogenous Nef and TNF activate NF-KappaB, AP-1, and MAPK, suggesting that they might modulate the cellular machinery in a similar way, and therefore might have the same effect on HIV-1 replication in mononuclear phagocytes.

Go back
968.0, 552.0
23.0, 23.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m33*m34*0.1

nodelay

--

true

0

false

PMID: 18178131,15638722 An interaction between Vpr and the transcription factors Sp1 and TFIIB is required for Vpr-mediated transcriptional enhancement of the HIV-1 LTR in lymphoid and myeloid cells

Go back
1064.0, 576.0
23.0, 23.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m33*m36*0.1

nodelay

--

true

0

false

PMID: 18178131,15638722 An interaction between Vpr and the transcription factors Sp1 and TFIIB is required for Vpr-mediated transcriptional enhancement of the HIV-1 LTR in lymphoid and myeloid cells

Go back
929.0, 741.0
21.0, 21.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m33*m38*0.1

nodelay

--

true

0

false

PMID: 18178131,12208951 The ability of Vpr to activate HIV transcription is mediated by the p300/CBP transcriptional coactivator, which, in turn, enhances the ability of Vpr to activate NF-KappaB and the HIV enhancer

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869.0, 869.0
21.0, 21.0

p17

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e38 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m39*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,12208951 The ability of Vpr to activate HIV transcription is mediated by the p300/CBP transcriptional coactivator, which, in turn, enhances the ability of Vpr to activate NF-KappaB and the HIV enhancer

Go back
357.0, 1145.0
21.0, 21.0

p53

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e95 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m96*m31*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
469.0, 181.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m12*0.1

nodelay

--

true

0

false

PMID: 18178131 TNF binds to the cell transmembrane receptors TNFR1 and TNFR2, mainly to modulate immunity PMID: 18178131 TNFalpha binds to two distinct cell transmembrane receptors, 55 kDa TNFR1 (also called TNF R55, TNF Rbeta, p55, or CD120a) and 75 kDa TNFR2 (also called TNF R75, TNF Ralpha, p75, and CD120b).

Go back
758.0, 542.0
19.0, 19.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e20

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m33*m21*0.1

nodelay

--

true

0

false

PMID: 18178131,16243842 Synthetic Vpr protein activates NF-KappaB, AP-1, and JNK in promonocytic U937 cells and in primary macrophages, resulting in enhanced HIV replication

Go back
752.0, 672.0
23.0, 23.0

p20

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m33*m17*0.1

nodelay

--

true

0

false

PMID: 18178131,16243842 Synthetic Vpr protein activates NF-KappaB, AP-1, and JNK in promonocytic U937 cells and in primary macrophages, resulting in enhanced HIV replication

Go back
728.0, 784.0
23.0, 23.0

p20

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m33*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,16243842 Synthetic Vpr protein activates NF-KappaB, AP-1, and JNK in promonocytic U937 cells and in primary macrophages, resulting in enhanced HIV replication

Go back
985.0, 741.0
21.0, 21.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m33*m43*0.1

nodelay

--

true

0

false

PMID: 18178131,10931842 A structural and functional interaction between Vpr and Tat synergistically enhances the transcriptional activity of the HIV-1 LTR

Go back
829.0, 813.0
21.0, 21.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m43*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
1081.0, 697.0
21.0, 21.0

p24

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m43*m17*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
417.0, 713.0
21.0, 21.0

p24

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m43*m31*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
645.0, 709.0
21.0, 21.0

p24

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e20

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m43*m21*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
697.0, 385.0
21.0, 21.0

p24

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e24

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m43*m25*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
1065.0, 453.0
21.0, 21.0

p24

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e18

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m43*m19*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
794.0, 742.0
19.0, 19.0

p3

p3

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m14*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,12574335 Recombinant Nef protein stimulates NF-¦ÊB activation in promonocytic U937 cells and monocyte-derived macrophages, leading to sustained LTR activation

Go back
1109.0, 565.0
21.0, 21.0

p24

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e22

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m43*m23*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
1069.0, 813.0
21.0, 21.0

p24

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e42 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m43*m48*0.1

nodelay

--

true

0

false

PMID: 18178131,16920714 ,9670954,16280076 In fact, Tat by itself displays biological activities that mimic those mediated by TNF. Like TNF, Tat activates NF-KappaB, AP-1, and MAPK, as well as c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38, and ERK1/2; however, unlike TNF, signalling does not modify the activation of MEK

Go back
786.0, 358.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 e14

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m63*m14*0.1

nodelay

--

true

0

false

PMID: 18178131 At more advanced stages of the disease, when TNF expression (plasma and membrane-bound) becomes more pronounced, Nef prevents TNFR-mediated death in HIV-infected T cells via interaction with the apoptosis signal-regulating kinase-1 (ASK-1)

Go back
496.0, 316.0
23.0, 23.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c102 : 1
stoichiometry:c98 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 18178131,11298454 Nef inhibits ASK-1, caspase 3, and caspase 8 activation, resulting in the blockade of apoptosis in HIV-infected cells

Go back
520.0, 384.0
23.0, 23.0

p33

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e65 e14

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c101 : 1
stoichiometry:c100 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18178131,11298454 Nef inhibits ASK-1, caspase 3, and caspase 8 activation, resulting in the blockade of apoptosis in HIV-infected cells

Go back
860.0, 368.0
23.0, 23.0

p33

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e67 e14

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c103 : 1
stoichiometry:c105 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 18178131,11298454 Nef inhibits ASK-1, caspase 3, and caspase 8 activation, resulting in the blockade of apoptosis in HIV-infected cells

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528.0, 656.0
23.0, 23.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m14*m70*0.1

nodelay

--

true

0

false

PMID: 18178131,11689886 In addition, Nef coprecipitates phosphatidylinositol-3-kinase (PI3K) in 293T cells, especially its p85 subunit, via sequences present within the N and C termini of Ne

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417.0, 769.0
21.0, 21.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18178131 This interaction leads to the activation of PI3K, which, in turn, phosphorylates Bad, the proapoptotic member of the Bcl-2 family.

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428.0, 868.0
23.0, 23.0

p38

p38

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e71 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m72*m73*0.1

nodelay

--

true

0

false

PMID: 18178131 This interaction leads to the activation of PI3K, which, in turn, phosphorylates Bad, the proapoptotic member of the Bcl-2 family.

Go back
427.0, 1007.0
25.0, 25.0

p39

p39

cso30:i:ME_UnknownInactivation

cso30:i:CC_Cytosol

--

e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m74*0.1

nodelay

--

true

0

false

PMID: 18178131 Phosphorylation of Bad results in its inactivation and subsequently inhibits mitochondrial-related apoptosis.

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861.0, 541.0
21.0, 21.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e14 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m14*m17*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

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641.0, 789.0
21.0, 21.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m14*m76*0.1

nodelay

--

true

0

false

PMID: 18178131,11689886,11160719 In fact, Nef interacts with PAK2 via its PXXP motif

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487.0, 543.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e77

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m14*m78*0.1

nodelay

--

true

0

false

PMID: 18178131 Another antiapoptotic effect of Nef in T cells involves the interaction with the tumor suppressor protein p53 via its N-terminal extremity (amino acids 1?57), both in the cytoplasm and in the nucleus of the cell.

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689.0, 1165.0
21.0, 21.0

p41

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e79 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m80*m81*0.1

nodelay

--

true

0

false

PMID: 18178131 Another antiapoptotic effect of Nef in T cells involves the interaction with the tumor suppressor protein p53 via its N-terminal extremity (amino acids 1?57), both in the cytoplasm and in the nucleus of the cell.

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829.0, 1153.0
21.0, 21.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e42

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 18178131,17356300 Tat can also protect lymphoid and myeloid cells from TRAIL (TNF-related apoptosis-inducing ligand)-mediated apoptosis by upregulating Bcl-2

Go back
1284.0, 1104.0
23.0, 23.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e83 e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m84*m85*0.1

nodelay

--

true

0

false

PMID: 18178131,8996241,11861282,12767990,15990565 TNF is expressed on the surface of activated macrophages, and most of the CD4+ T lymphocyte death is mediated via TNF-mediated apoptosis and via Fas-Fas ligand and TRAIL-DR5 (death receptor) interactions

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344.0, 344.0
23.0, 23.0

p45

p45

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e86 e13

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c130 : 1
stoichiometry:c132 : 1

m87*m13*0.1

nodelay

--

true

0

false

PMID: 18178131 The engagement of TNFR2 by TNF results in degradation of TRAF2 (TNFR-associated factor).

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293.0, 381.0
21.0, 21.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 e88 e86

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m11*m89*m87*0.1

nodelay

--

true

0

false

PMID: 18178131 Because TRAF2 recruits cIAP (cellular inhibitor of apoptosis proteins) to TNFR1, its degradation can facilitate apoptosis.

Go back
485.0, 845.0
21.0, 21.0

p47

p47

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m11*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,14980217 TRAF2 degradation also attenuates TNFR1-mediated NF-¦ÊB activation, further promoting apoptosis

Go back
489.0, 997.0
21.0, 21.0

p48

p48

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e90 e91

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m91*m92*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,11313374,11602715 HIV-1 gp120 has been reported to trigger the production of TNF and C-C chemokines, especially in mononuclear phagocytes

Go back
453.0, 1345.0
21.0, 21.0

p48

p49

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e92 e90

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m93*m91*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,11313374,11602715 HIV-1 gp120 has been reported to trigger the production of TNF and C-C chemokines, especially in mononuclear phagocytes

Go back
869.0, 433.0
21.0, 21.0

p5

p5

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m14*m19*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

Go back
410.0, 1214.0
19.0, 19.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e90 e94 MO000018835

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c206 : 1
stoichiometry:c148 : 1

m91*m95*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression PMID: 18178131 Vpu is a 16 kDa viral membrane protein that regulates the release of virions from infected cells and induces the disruption of an envelope gp120-CD4 interaction in the endoplasmic reticulum.

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617.0, 145.0
21.0, 21.0

p51

p51

cso30:i:CE_Apoptosis_InhibitionOfCellSurvival_

cso30:i:CC_Extracellular

--

e12 e63 e74 e108 e117

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c156 : 1
stoichiometry:c203 : 1

m12*m109*m118*0.1

nodelay

--

true

0

false

PMID: 18178131 At more advanced stages of the disease, when TNF expression (plasma and membrane-bound) becomes more pronounced, Nef prevents TNFR-mediated death in HIV-infected T cells via interaction with the apoptosis signal-regulating kinase-1 (ASK-1) PMID: 18178131 Phosphorylation of Bad results in its inactivation and subsequently inhibits mitochondrial-related apoptosis. PMID: 18178131,17356300 Tat can also protect lymphoid and myeloid cells from TRAIL (TNF-related apoptosis-inducing ligand)-mediated apoptosis by upregulating Bcl-2

Go back
998.0, 914.0
19.0, 19.0

p52

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e105 e106 e14

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1
stoichiometry:c155 : 1

m106*m107*m14*0.1

nodelay

--

true

0

false

PMID: 18178131 We observed that Nef binds directly to Akt in primary PBLs, suggesting the potential formation of a Nef-Akt-PI3K complex in HIV-infected T cells

Go back
401.0, 1405.0
21.0, 21.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e95 e109

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m96*m110*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
258.0, 1462.0
19.0, 19.0

p54

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e110 e95

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m111*m96*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
293.0, 1165.0
21.0, 21.0

p53

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e95 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m96*m40*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
405.0, 1069.0
21.0, 21.0

p53

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m41*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
437.0, 1125.0
21.0, 21.0

p53

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e16 e40

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c169 : 1
stoichiometry:c171 : 1

m17*m41*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
441.0, 1173.0
21.0, 21.0

p53

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e112 e40

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c172 : 1
stoichiometry:c174 : 1

m113*m41*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
801.0, 1257.0
21.0, 21.0

p59

p59

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c175 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
717.0, 525.0
21.0, 21.0

p5

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e20

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m14*m21*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

Go back
737.0, 1261.0
21.0, 21.0

p59

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
893.0, 1285.0
21.0, 21.0

p59

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
389.0, 1013.0
21.0, 21.0

p53

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e15

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m32*m16*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
573.0, 1069.0
21.0, 21.0

p53

p63

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e112

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1

m32*m113*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
661.0, 1021.0
21.0, 21.0

p53

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m32*m17*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
637.0, 1305.0
21.0, 21.0

p59

p65

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m114*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
673.0, 1297.0
21.0, 21.0

p59

p66

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000058

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c193 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
653.0, 1141.0
21.0, 21.0

p59

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18178131,16081599,9621091,10704341,11698270 Interactions between HIV-1 gp120 and CD4 stimulates signal transduction pathways, such as activation of protein kinase C (PKC); the generation of PKC-dependent phosphorylation of CD4; activation of the ERK and MAPK pathways, which, in turn, stimulates transcription factors, such as NF-¦ÊB, AP-1, Elk-1; and the induction of proinflammatory cytokine and C-C chemokine gene expression

Go back
350.0, 1546.0
19.0, 19.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e115 e116

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m116*m117*0.1

nodelay

--

true

0

false

PMID: 18178131,11462036,17082816 Furthermore, the binding of a cell-associated gp120 molecule to CXCR4 induces mitochondrial transmembrane depolarization; cytochrome C release from the mitochondria to the cytosol; and, ultimately, activation of downstream caspases, resulting in T cell apoptosis

Go back
246.0, 1178.0
19.0, 19.0

p69

p69

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017157 e90

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m2033*m91*0.1

nodelay

--

true

0

false

PMID: 18178131,11462036,17082816 Furthermore, the binding of a cell-associated gp120 molecule to CXCR4 induces mitochondrial transmembrane depolarization; cytochrome C release from the mitochondria to the cytosol; and, ultimately, activation of downstream caspases, resulting in T cell apoptosis

Go back
917.0, 481.0
21.0, 21.0

p5

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m14*m23*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

Go back
293.0, 1013.0
22.0, 22.0

p70

p70

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e115 MO000016985

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c204 : 1
stoichiometry:c205 : 1

m116*m1889*0.1

nodelay

--

true

0

false

PMID: 18178131,11462036,17082816 Furthermore, the binding of a cell-associated gp120 molecule to CXCR4 induces mitochondrial transmembrane depolarization; cytochrome C release from the mitochondria to the cytosol; and, ultimately, activation of downstream caspases, resulting in T cell apoptosis

Go back
261.0, 449.0
21.0, 21.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000016962 e6 MO000018835

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c208 : 1
stoichiometry:c210 : 1
stoichiometry:c209 : 1

m1871*m6*0.1

nodelay

--

true

0

false

PMID: 18178131,11278695,14561767 Vpu functions as a competitive inhibitor of TNFR-complex proteins, such as TRAF1

Go back
353.0, 453.0
21.0, 21.0

p71

p72

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e12 MO000016962 MO000018835

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c212 : 1
stoichiometry:c214 : 1
stoichiometry:c213 : 1

m12*m1871*0.1

nodelay

--

true

0

false

PMID: 18178131,11278695,14561767 Vpu functions as a competitive inhibitor of TNFR-complex proteins, such as TRAF1

Go back
748.0, 1364.0
23.0, 23.0

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c215 : 1

m13*0.1

nodelay

--

true

0

false

PMID: 18178131,16921384,16917489 PD-1 expression is upregulated by TNF and correlates with impaired, HIV-specific T cell functions as well as with predictors of disease progression: it is correlated positively with plasma viral load and inversely with CD4 T cell count

Go back
708.0, 1396.0
23.0, 23.0

p73

p74

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e11

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 18178131,16921384,16917489 PD-1 expression is upregulated by TNF and correlates with impaired, HIV-specific T cell functions as well as with predictors of disease progression: it is correlated positively with plasma viral load and inversely with CD4 T cell count

Go back
329.0, 845.0
21.0, 21.0

p75

p75

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016985 e68 MO000017052

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c220 : 1

m1889*m69*0.1

nodelay

--

true

0

false

PMID: 18178131 Activated caspase 8 induces the release of cytochrome C from the mitochondria. PMID: 18178131 The release of cytochrome C is usually inhibited by members of the Bcl-2 protein family

Go back
241.0, 657.0
21.0, 21.0

p76

p76

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e118 e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1

m119*m66*0.1

nodelay

--

true

0

false

PMID: 18178131,11696595 Vpu-expressing cells, the levels of these proteins are limited, resulting in increased release of cytochrome C and, subsequently, in caspase 3 activation

Go back
681.0, 433.0
21.0, 21.0

p5

p8

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m14*m25*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

Go back
665.0, 501.0
21.0, 21.0

p5

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m14*m27*0.1

nodelay

--

true

0

false

PMID: 18178131,12419805,17182689 Moreover, recombinant Nef protein activates AP-1, and induces the rapid phosphorylation of mitogen-activated protein kinase (MAPK)-family members (i.e. ERK1/2, p38, and JNK), interferon regulatory factor 3 (IRF-3), and both the alpha and beta subunits of the IKappaB kinase (IKK) complex, required for the activation of the NF-KappaB pathway in monocyte-derived macrophages

Go back
292.0, 210.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.0, 451.0

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
326.41536394787454, 405.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.9340606630954, 398.7233026331252

c101

c101

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
523.0, 328.0

c102

c102

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
793.0, 390.2640260107696

c103

c103

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
890.3162827020662, 352.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0, 380.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.8263773812037, 451.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.0, 674.197769023179

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
530.8231932086841, 679.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.0, 780.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.0, 569.1554175279994

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 780.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 790.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
317.0, 883.4185980428581

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.0, 891.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.37169119481973, 964.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.0, 960.9425724154552

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.6963369881353, 451.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 737.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
573.2862551987165, 805.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.4396857613915, 448.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.0, 562.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 554.3995009355511

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.48045008205503, 558.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 1179.5689290811056

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
717.9195959492894, 1178.1313708498985

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.3632612873492, 1186.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.3053404524461, 829.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
843.0, 1174.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1228.0, 1062.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1296.0, 1061.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1230.9320762448115, 1118.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.0, 442.0

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
374.1854160649823, 258.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
254.0, 338.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
311.03471347254214, 367.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
315.26735569219176, 270.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 400.0769230769231

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 346.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
183.8856185318273, 371.34796897979953

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 273.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.7190127890126, 866.3422191493619

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.0, 859.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.8318433579009, 447.631634032896

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 1025.3404450024793

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.8407288806694, 1025.4786535838032

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.20079479206316, 207.90936734937466

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.7959930941093, 1359.7951299887752

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
392.0, 1284.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
110.0, 1356.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 1239.592335393595

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
372.0, 1208.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.5894663844041, 1227.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
493.0, 168.73316390978206

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
880.0, 454.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.1557003439788, 166.45795755435532

c150

c150

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
533.0, 169.97082359520215

c151

c151

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1023.3360815775754, 935.8840628827144

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 924.0

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
784.0, 451.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.0, 933.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.9003360610683, 159.2588447569834

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
310.0, 1277.0

c157

c157

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
418.65524969272747, 1433.546499126699

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.70975574618194, 1426.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
737.8771118950373, 451.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
284.8868467733585, 1475.340763951471

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
271.19717645097484, 1277.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.8812105304085, 1481.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.0, 1193.9914928787896

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
249.0, 1059.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.0, 1103.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 1080.2889679298512

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
433.2486491185911, 969.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 969.1065596304293

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 1090.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
685.0, 552.9525178510431

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
460.85470277686926, 643.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.0, 718.7049950561076

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.0, 1095.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
463.1159660434202, 1093.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.0, 1156.2724472327432

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.0, 1278.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.7344735336083, 975.0

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
544.0, 1155.0

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
758.0, 1281.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 718.0

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
731.0, 546.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
866.1214751973158, 1306.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.17108385957977, 639.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
417.8026368532015, 967.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
410.0, 967.0783728398177

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
412.0, 639.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 1081.3262589561145

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.8406661402685, 1090.0

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.0, 639.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
678.9711254108329, 646.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 724.8279252123396

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
794.0, 447.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.0, 1157.0

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.0, 1326.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.3036028817036, 975.0

c192

c192

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
663.320059162263, 1318.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.3774513221406, 718.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
657.2521269463605, 1162.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.0, 1188.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.6009990854674, 1198.5196029774372

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
185.73269083704474, 1194.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
179.0, 1041.8157030441575

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
310.0, 192.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.4708540135694, 498.8611781328563

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
179.0, 1261.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
353.0, 1572.982281262853

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.0, 1556.0

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 173.99946313031666

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 952.0

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
315.0, 968.3343588757587

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.9495834861353, 1236.8856519662547

c206

c206

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
245.0, 477.0097272694132

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
273.81501442845206, 283.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
183.0, 460.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.0, 502.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.825452075226, 473.91390200075386

c210

c210

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
374.02591024277257, 283.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 472.2622626448296

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
190.72295770687066, 471.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.51933356174817, 477.96614329691226

c214

c214

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
765.0, 1387.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 274.0

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
398.0, 273.0

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
731.0, 1417.0

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
285.0, 872.3752370762162

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.9960966086966, 442.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
345.0, 866.0

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.6519688219048, 386.0

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.0, 869.9998953636277

c222

c222

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
260.3542232292758, 685.2628635212419

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
257.38842928556886, 462.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
258.0, 580.9972311490668

c225

c225

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 444.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.323320417402, 453.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.6564023547028, 451.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.0, 512.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
598.9751546033311, 518.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.0, 615.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.6518879601005, 638.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
302.0, 198.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.9791383377085, 451.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
628.0, 689.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
666.0, 709.8080298118809

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.0, 702.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 273.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
406.0575462593444, 524.8946586828704

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 518.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 273.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
489.2543346847117, 472.37262928324316

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 470.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.0, 192.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
403.0, 268.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.0, 468.16152364616806

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.37799490386163, 462.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
924.0, 580.8325842630261

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
989.8553499981773, 582.0097272694131

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 575.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.0, 593.1292760037462

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1039.0, 510.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 599.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
918.0, 641.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.0, 210.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
860.0, 752.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.0, 762.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0640869902634, 834.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.0, 886.918089998585

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.4394686431388, 890.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 1172.7525610812272

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 675.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.0, 646.9775356492437

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.0510010135321, 560.7793365432532

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
692.0, 564.8915800086061

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.0, 199.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.9544177959076, 561.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.5774489628445, 637.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.3843309514476, 639.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
775.0, 686.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
756.8421713081511, 641.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.0, 814.2897559784257

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.0, 807.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
922.0, 641.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 770.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 754.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 451.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
857.9964381120229, 820.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.0, 837.9677092019386

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 834.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1004.0, 724.0971318494676

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
841.0, 635.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.99840047984, 704.1599680095968

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.88879589410715, 727.329247659813

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
362.0, 675.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.6906623402203, 646.8193133235189

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.6783753849967, 725.2455626125934

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.0, 767.6723982934668

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.8707072438639, 630.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.0, 687.8700853921454

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.4940092724321, 412.6184500193999

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.0, 404.352465419694

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
630.8405438169862, 380.58929942236205

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.0, 481.8040092135777

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
990.0, 464.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.87281235127, 433.09444140075664

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1001.0, 593.1362862082422

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1015.0, 527.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.0, 761.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1122.0, 512.9114908229463

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.0, 821.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1097.6626102817693, 806.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.0, 834.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.0, 368.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.0, 384.828398279894

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.0, 341.8

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.8634531295569, 331.4717693023235

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.00829016433363, 339.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 400.90217060580534

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back