1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18241699.csml convertedTime:2009.07.01.11:14

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptor 9 in murine lupus: more friend than foe!
Authors Yu P, Musette P, Peng SL.
Affiliation Institute of Immunology, Philipps University Marburg, Hans Meerwein Street 2,35043 Marburg, Germany. Phillipp.Yu@staff.uni-marburg.de
Abstract The immune response induced by the pathogen-associated-pattern recognitionreceptor toll-like receptor 9 (TLR9) upon binding of CpG motif-containing DNAhas been widely accepted as an important pathway in the immune defense againstmicrobial pathogens. In contrast, the role of TLR9 in anti-DNA antibodygeneration and the pathogenesis of systemic lupus erythematosus (SLE) remainscontroversial. Indeed, the in vivo situation might consist of a delicate balancebetween B-cell receptor and DNA receptor signaling. Most surprisingly, TLR9deletion does not ameliorate but rather exacerbates pathology in murine models.Such observations warrant caution with therapeutic efforts to treat autoimmunediseases, especially SLE, via TLR modulation.
PMID 18241699
Model Abstract

Entity

MO000000210:IKK-alpha MO000016573:MyD88 MO000016658:IFN Type I MO000042012:TLR9 MO000042126:TLR7 e1: e10: e11: e12: e13: e14:CpG DNA: TLR9: MyD88 e15:ssRNA e16:ssRNA: TLR7 e17:ssRNA: TLR7: MyD88 e18:Unc93b1 e19:Unc93b1 {activated} e2: e21:cytosolic DNA e22:DLM-1 e23:cytosolic DNA: DLM-1 e24:IFN Type I e25:IKK-alpha{active} e3: e4: e5:CpG DNA e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:CpG DNA: TLR9 e60: e61: e62: e7: e8: e9:

Process

p1 p10 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
600.0, 416.0
40.0, 40.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p10

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
446.0, 315.0
33.0, 33.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p4

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
725.0, 766.0
36.0, 36.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
271.0, 192.0
32.0, 32.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
275.0, 264.0
32.0, 32.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
123.75, 91.99690800911759
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
141.0, 112.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
274.0, 176.36040050822072
138.77021978647122, 231.67570591470195

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
274.0, 176.36040050822072
138.77021978647122, 231.67570591470195

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
274.0, 176.36040050822072
138.77021978647122, 231.67570591470195

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
390.875, 245.5
32.25, 45.0

CpG DNA: TLR9: MyD88

--

e14

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p2

p5 p7

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
48.5, 267.625
45.0, 24.75

ssRNA

--

e15

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
276.625, 309.5
36.75, 45.0

ssRNA: TLR7

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
346.625, 375.5
33.639018496917174, 41.1906348941843

ssRNA: TLR7: MyD88

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
603.5, 309.125
38.6, 28.949999999999996

Unc93b1

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5 p6

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
603.5, 365.125
38.6, 28.949999999999996

Unc93b1 {activated}

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

p5 p6

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
123.75, 91.99690800911759
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
760.5, 568.125
45.0, 15.75

cytosolic DNA

--

e21

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
552.5, 570.125
45.0, 27.75

DLM-1

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
650.5, 651.25
56.98316183348925, 24.69270346117867

cytosolic DNA: DLM-1

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p9

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
632.5, 896.0
45.0, 24.0

IFN Type I

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p9

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
596.0, 488.0
40.0, 40.0

IKK-alpha{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p10

--

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
140.87518862352903, 109.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
172.5567875770579, 139.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
408.0, 46.5
54.38752783964365, 19.035634743875274

CpG DNA

--

e5

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
355.2936761946803, 819.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
311.06992643728904, 814.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
311.93705878547314, 815.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
311.93705878547314, 815.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
644.9158804881849, 982.4264696368292
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
568.6082338479803, 1103.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
305.0, 809.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
357.5, 182.0
35.82119646725546, 43.862689551741376

CpG DNA: TLR9

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
414.7511016961721, 996.6637213250546
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
414.2586758712023, 975.4894108513561
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
435.43298634490134, 1034.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
135.0, 97.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
138.0, 118.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
146.0, 139.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
318.0, 43.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*m19828*0.1

nodelay

--

true

0

false

PMID: 18241699 The immune response induced by the pathogen-associated-pattern recognition receptor toll-like receptor 9 (TLR9) upon binding of CpG motif-containing DNA has been widely accepted as an important pathway in the immune defense against microbial pathogens.

Go back
469.0, 485.0
30.0, 30.0

p7

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c30 : 1
stoichiometry:c28 : 1

m181*m17*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
461.0, 254.0
27.0, 27.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m1572*m6*0.1

nodelay

--

true

0

false

PMID: 18241699 Upon subsequent delivery to endosomes, this DNA interacts with and stimulates TLR9, which results in signaling via MyD88 pathway.

Go back
201.0, 266.0
27.0, 27.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m15*m19940*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
390.0, 319.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m1572*m16*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
536.0, 309.0
29.0, 29.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c17 : 1
stoichiometry:c14 : 1

m18*m14*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
536.0, 365.0
30.0, 30.0

p6

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1

m18*m17*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
489.0, 421.0
30.0, 30.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c29 : 1
stoichiometry:c20 : 1

m181*m14*0.1

nodelay

--

true

0

false

PMID: 18241699, 16415873, 16612387 It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and I¦ÊB-alpha are used by both TLRs.

Go back
665.0, 582.0
28.0, 28.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m22*m21*0.1

nodelay

--

true

0

false

PMID: 18241699, 11842111 One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.

Go back
640.0, 769.0
30.0, 30.0

p9

p9

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c24 : 1

m24*m23*0.1

nodelay

--

true

0

false

PMID: 18241699, 11842111 One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.

Go back
351.0, 56.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 332.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.0, 332.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.23999152002546, 344.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 324.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
565.0, 335.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.3409919128368, 338.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 380.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 274.0

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
380.0, 381.71507491748497

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.0, 436.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 75.68276981402899

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 446.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 586.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.8576953209139, 580.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
679.0, 610.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 784.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.0, 807.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
659.601331299634, 676.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
506.22552674241246, 445.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
499.0, 501.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 291.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.0, 68.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.0, 411.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
466.0, 288.8356563460532

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.0, 216.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 268.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
94.0, 280.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 280.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 288.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back