_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e4
_enti_e2
_enti_e3
_enti_e55
_enti_e13
_enti_e53
_enti_e59
_enti_e12
_enti_e11
_enti_e51
_enti_e52
_enti_e54
_enti_e50
_enti_e56
_enti_e61
_enti_e58
_enti_e57
_enti_e62
_enti_e60
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g1
g1_fact_g3
p1_propro_p1
PMID: 18241699
The immune response induced by the pathogen-associated-pattern recognition receptor toll-like receptor 9 (TLR9) upon binding of CpG motif-containing DNA has been widely accepted as an important pathway in the immune defense against microbial pathogens.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18241699
Upon subsequent delivery to endosomes, this DNA interacts with and stimulates TLR9, which results in signaling via MyD88 pathway.
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18241699, 16415873, 16612387
It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and IκB-alpha are used by both TLRs.
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18241699, 16415873, 16612387
It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and IκB-alpha are used by both TLRs.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 18241699, 16415873, 16612387
It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and IκB-alpha are used by both TLRs.
c13 cso30:c:InputProcess connector
c17 cso30:c:InputAssociation connector
c14 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18241699, 16415873, 16612387
It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and IκB-alpha are used by both TLRs.
c15 cso30:c:InputProcess connector
c18 cso30:c:InputAssociation connector
c16 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 18241699, 16415873, 16612387
It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and IκB-alpha are used by both TLRs.
c19 cso30:c:InputProcess connector
c29 cso30:c:InputAssociation connector
c20 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18241699, 11842111
One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.
c21 cso30:c:InputProcess connector
c22 cso30:c:InputProcess connector
c23 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18241699, 11842111
One most recently identified candidate is DLM-1 (also called DAI or ZBP-1), a gene prominently expressed in lymph node and spleen, which is able to act as a positive regulator of type I IFN induction by directly binding cytosolic DNA, regardless of bacterial or mammalian origin.
c25 cso30:c:InputAssociation connector
c26 cso30:c:InputAssociation connector
c24 cso30:c:OutputProcess connector
p7_propro_p10
PMID: 18241699, 16415873, 16612387
It raises the question of how the endosomal ssRNA and DNA-recognizing receptors, TLR7 and TLR9 respectively, execute their different functions at the signaling level, because known signaling molecules e.g. MyD88, Unc93b1 and IκB-alpha are used by both TLRs.
c27 cso30:c:InputProcess connector
c30 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
TLR9_enti_MO000042012
TLR9
MyD88_enti_MO000016573
MyD88
CpG DNA_enti_e5
CpG DNA
CpG DNA: TLR9_enti_e6
CpG DNA: TLR9
CpG DNA: TLR9: MyD88_enti_e14
CpG DNA: TLR9: MyD88
TLR7_enti_MO000042126
TLR7
ssRNA_enti_e15
ssRNA
ssRNA: TLR7_enti_e16
ssRNA: TLR7
ssRNA: TLR7: MyD88_enti_e17
ssRNA: TLR7: MyD88
Unc93b1_enti_e18
Unc93b1
Unc93b1 {activated}_enti_e19
Unc93b1 {activated}
cytosolic DNA_enti_e21
cytosolic DNA
DLM-1_enti_e22
DLM-1
cytosolic DNA: DLM-1_enti_e23
cytosolic DNA: DLM-1
IFN Type I_enti_MO000016658
IFN Type I
IFN Type I_enti_e24
IFN Type I
IKK-alpha_enti_MO000000210
IKK-alpha
IKK-alpha{active}_enti_e25
IKK-alpha{active}