1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18243041.csml convertedTime:2009.07.01.11:14

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Fragments of extracellular matrix as mediators of inflammation.
Authors Adair-Kirk TL, Senior RM.
Affiliation Department of Internal Medicine, Washington University School of Medicine, St.Louis, MO 63110, United States. tkirk@im.wustl.edu
Abstract Classically, the extracellular matrix (ECM) was viewed as a supporting structurefor stabilizing the location of cells in tissues and for preserving thearchitecture of tissues. This conception has changed dramatically over the pastfew decades with discoveries that ECM has profound influences on the structure,viability, and functions of cells. Much of the data supporting this new paradigmhas been obtained from studies of normal and pathological structural cells suchas fibroblasts, smooth muscle cells, and malignant cells, as, for example,breast cancer epithelial cells. However, there has also been recognition thateffects of ECM on cells extend to inflammatory cells. In this context, attentionhas been drawn to fragments of ECM components. In this review, we presentinformation supporting the concept that proteolytic fragments of ECM affectmultiple functions and properties of inflammatory and immune cells. Our focus isparticularly upon neutrophils, monocytes, and macrophages and fragments derivedfrom collagens, elastin, and laminins. Hyaluronan fragments, although they arenot products of proteolysis, are also discussed, as they are a notable exampleof ECM fragments that exhibit important effects on inflammatory cells. Further,we summarize some exciting recent developments in this field as a result ofmouse models in which defined ECM fragments and their receptors are clearlyimplicated in inflammation in vivo. Thus, this review underscores the idea thatproteolysis of ECM may well have implications that go beyond modifying thestructural environment of cells and tissues.
PMID 18243041
Model Abstract

Entity

G010262:IL-6 G010279:MMP-9 G010329:TNF-alpha G010417:PAI-1 G010422:uPA G010453:IFN-gamma G010815:MCP1 G010861:MMP14 G024078:MMP12 MO000000058:NF-kappaB MO000000214:IL-1 MO000000289:TNF-alpha MO000002553:CD44 MO000007384:IL-6 MO000017264:IL-8 MO000017265:IL-12 MO000017280:MCP-1 MO000019886:MIP-1alpha MO000019951:MIP-1beta MO000021957:MMP9 MO000036944:EBP MO000062812:MMP12 e1: e10: e11:MIP-1beta e12:KC e13:IL8 e14:IL12 e15:XGXXPG e16:XGXXPG: EBP e17:PPCA e18:XGXXPG: EBP: PPCA e19:XGXXPG: EBP: PPCA: NEU1 e2: e20:NEU1 e21:IL-1 e22:SIKVAV e23:hyaluronan fragment e24:hyaluronan fragment: CD44 e25:KC e26:IFNgamma e27:fibronectin fragmant e28:fibronectin fragment recptor e29:fibronectin fragmant : fibronectin fragment recptor e3: e30:SIKVAV receptor e31:SIKVAV :SIKVAV receptor e32:ASKVKV e33:ASKVKV receptor e34:ASKVKV: ASKVKV receptor e35:MT1-MMP e36:TNFR-II e37:VGVAPG e38:NF-kappaB e39:NF-kappaB_DNA e4: e5:DNA e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:MIP-1alpha e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p5 p6 p7 p8 p9
Model Detail
814.0, 1018.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27

p30

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
611.0, 1115.0
29.0, 29.0

MMP-9

--

G010279

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p22 p32 p36

p23 p39

true true true true

csml-variable:Double

m93262

10

false

infinite

0

unit false false false
TRANSFACG010279

--

Go back
807.0, 975.0
25.0, 25.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p28 p40

p31

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
357.0, 913.0
30.0, 30.0

PAI-1

--

G010417

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m93390

10

false

infinite

0

unit false false false
TRANSFACG010417

--

Go back
717.0, 1097.0
30.0, 30.0

uPA

--

G010422

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m93394

10

false

infinite

0

unit false false false
TRANSFACG010422

--

Go back
783.0, 939.0
25.0, 25.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13

p21

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
403.0, 1075.0
26.0, 26.0

MCP1

--

G010815

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p5

p8

true true true true

csml-variable:Double

m93710

10

false

infinite

0

unit false false false
TRANSFACG010815

--

Go back
693.0, 1169.0
30.0, 30.0

MMP14

--

G010861

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p37

p38

true true true true

csml-variable:Double

m93747

10

false

infinite

0

unit false false false
TRANSFACG010861

--

Go back
565.0, 1137.0
27.0, 27.0

MMP12

--

G024078

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p1 p25

p24

true true true true

csml-variable:Double

m102788

10

false

infinite

0

unit false false false
TRANSFACG024078

--

Go back
632.0, 664.0
32.0, 32.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
657.0, 1437.0
30.0, 30.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

--

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1027.0, 987.0
34.0, 34.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
561.0, 189.0
31.0, 31.0

CD44

--

MO000002553

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m399

10

false

infinite

0

unit false false false
InterProIPR001231
TRANSPATHMO000002553

--

Go back
1031.0, 1047.0
34.0, 34.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
251.0, 1171.0
34.0, 34.0

IL-8

--

MO000017264

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

--

true true true true

csml-variable:Double

m2120

10

false

infinite

0

unit false false false
InterProIPR002473
TRANSPATHMO000017264

--

Go back
385.0, 1261.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
218.0, 1046.0
36.0, 36.0

MCP-1

--

MO000017280

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

--

true true true true

csml-variable:Double

m2133

10

false

infinite

0

unit false false false
InterProIPR008097
TRANSPATHMO000017280

--

Go back
231.0, 915.0
34.0, 34.0

MIP-1alpha

--

MO000019886

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m4415

10

false

infinite

0

unit false false false
InterProIPR000827
TRANSPATHMO000019886

--

Go back
214.0, 982.0
36.0, 36.0

MIP-1beta

--

MO000019951

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7

--

true true true true

csml-variable:Double

m4479

10

false

infinite

0

unit false false false
InterProIPR000827
TRANSPATHMO000019951

--

Go back
583.0, 1499.0
34.0, 34.0

MMP9

--

MO000021957

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m6281

10

false

infinite

0

unit false false false
InterProIPR006026
TRANSPATHMO000021957

--

Go back
165.0, 165.0
38.0, 38.0

EBP

--

MO000036944

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m15253

10

false

infinite

0

unit false false false
TRANSPATHMO000036944

--

Go back
535.0, 1447.0
34.0, 34.0

MMP12

--

MO000062812

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

--

true true true true

csml-variable:Double

m37698

10

false

infinite

0

unit false false false
TRANSPATHMO000062812

--

Go back
142.75, 167.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
151.0, 187.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
385.0, 1034.0
37.73356401384082, 20.12456747404844

MIP-1beta

--

e11

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p4

p7

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
416.0, 1124.0
30.0, 30.0

KC

--

e12

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p12

p15

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
Affymetrix128677_at
EnsemblENSMUSG00000030669
MGDCalca
ProteomeHumanPSD/Calca
RefSeqNM_001033954
TRANSFACG005845
UnigeneMm.4361

--

Go back
449.0, 1173.0
27.0, 27.0

IL8

--

e13

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

p16

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
TRANSFACG011190

--

Go back
536.0, 1196.0
24.0, 24.0

IL12

--

e14

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p19

p17

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSFACG013400

--

Go back
101.0, 99.0
50.28595458368377, 28.49537426408747

XGXXPG

--

e15

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
222.375, 146.5
31.304154790616096, 60.58868669151502

XGXXPG: EBP

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

p10

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
259.5, 283.125
33.16, 24.869999999999997

PPCA

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
268.375, 135.5
34.267540013155006, 66.32427099320324

XGXXPG: EBP: PPCA

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
355.375, 120.5
41.00312431484324, 79.36088577066432

XGXXPG: EBP: PPCA: NEU1

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

p21 p13

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
142.75, 167.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
317.0, 252.0
34.0, 34.0

NEU1

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000069179

--

Go back
647.0, 1187.0
26.0, 26.0

IL-1

--

e21

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p26

p29

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
1065.5, 1111.25
45.0, 25.5

SIKVAV

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p34

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
561.5, 103.25
45.0, 25.5

hyaluronan fragment

--

e23

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
476.625, 155.5
39.64051824695884, 48.53941009831694

hyaluronan fragment: CD44

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p1 p2 p3 p4 p5 p6 p7 p8 p12 p15 p16 p17 p18 p19

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
252.125, 1120.5
23.52057758100221, 38.14147715838197

KC

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1023.0, 895.0
34.0, 34.0

IFNgamma

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

--

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
933.5, 103.25
45.0, 25.5

fibronectin fragmant

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
785.375, 165.5
29.25, 45.0

fibronectin fragment recptor

--

e28

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p20

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
847.375, 148.5
32.948969524227145, 63.77219907914932

fibronectin fragmant : fibronectin fragment recptor

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

p22 p23 p24 p25 p26 p27 p28 p29 p30 p31

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
159.87518862352903, 185.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
947.375, 1140.5
25.64015817223199, 39.44639718804921

SIKVAV receptor

--

e30

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p34

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
956.375, 1077.5
23.25, 45.0

SIKVAV :SIKVAV receptor

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p34

p32 p33

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1061.5, 1207.25
45.0, 25.5

ASKVKV

--

e32

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
956.375, 1253.5
23.74384885764499, 36.52899824253075

ASKVKV receptor

--

e33

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p35

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
952.375, 1193.5
23.25, 45.0

ASKVKV: ASKVKV receptor

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

p36 p37 p38 p39 p40 p41

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
752.0, 1288.0
32.0, 32.0

MT1-MMP

--

e35

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
Affymetrix1301_s_at
BRENDA3.4.24.80
EnsemblENSG00000157227
HGNCMMP14
InterProIPR006026
OMIM600754
PROSITEPS00142
ProteomeHumanPSD/MMP14
RefSeqNM_004995
TRANSPATHMO000003223
UnigeneHs.2399
UniProtP50281

--

Go back
709.5, 1136.0
32.076124567474054, 17.10726643598616

TNFR-II

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p41

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
998.5, 732.25
42.72918418839361, 24.213204373423043

VGVAPG

--

e37

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p42 p43

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
576.0, 800.0
32.0, 32.0

NF-kappaB

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p43

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
698.0, 867.5
60.0, 17.0

NF-kappaB_DNA

--

e39

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p43

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
191.55678757705792, 215.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
546.0, 897.5
60.0, 13.0

DNA

--

e5

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p43

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
310.0, 763.0546240233818
549.3363125026157, 498.18768005358316

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
369.3324136408783, 774.860947789684
321.2134117799281, 482.84309031887307

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
317.1608085428645, 769.7039462417563
535.0146954168865, 484.88903561683446

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
318.1837811918454, 770.7269188907366
532.968750118925, 482.84309031887307

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
310.0, 763.0546240233818
549.3363125026157, 498.18768005358316

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
310.0, 763.0546240233818
549.3363125026157, 498.18768005358316

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
318.1837811918454, 770.7269188907366
532.968750118925, 482.84309031887307

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
711.0052784004197, 967.6491538195143
34.31951447455645, 31.06819205065115

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
620.9836852901212, 1110.8653246768076
97.18240165316286, 87.9756478123371

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
310.0, 763.0546240233818
549.3363125026157, 498.18768005358316

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
354.0, 978.0
28.0, 28.0

MIP-1alpha

--

e6

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p3

p6

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
Affymetrix102424_at
EnsemblENSMUSG00000000982
MGDCcl3
ProteomeHumanPSD/Ccl3
RefSeqNM_011337
TRANSFACG001238
UnigeneMm.1282

--

Go back
439.4754779541875, 984.4451124805051
17.39667385203434, 8.376176299127655

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
438.8945537715635, 959.4653726276695
59.54472871896872, 107.18051169414372

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
463.8742936243997, 1029.1762745425608
9.29478692198535, 9.294786921985354

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
154.0, 173.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
157.0, 194.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
165.0, 215.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
551.0, 1079.0
25.0, 25.0

p1

p1

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

G024078

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c19 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
263.0, 210.0
30.0, 30.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m16*m17*0.1

nodelay

--

true

0

false

PMID: 18243041 EBP complexes with the 55-kDa protective protein-cathepsin A (PPCA) and the 61-kDa neuraminidase (Neu-1) on the cell surface.

Go back
319.0, 202.0
30.0, 30.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 e20

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m18*m20*0.1

nodelay

--

true

0

false

PMID: 18243041 EBP complexes with the 55-kDa protective protein-cathepsin A (PPCA) and the 61-kDa neuraminidase (Neu-1) on the cell surface.

Go back
479.0, 1123.0
25.0, 25.0

p12

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c24 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
784.0, 892.0
23.0, 23.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e19

G010453

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c52 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 18243041 In these same studies, stimulation of T cells with elastin peptides resulted in interferon gamma release that correlated with the severity of emphysema.

Go back
481.0, 101.0
30.0, 30.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e23 MO000002553

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c20 : 1
stoichiometry:c22 : 1

m23*m399*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages. PMID: 18243041 Initial studies indicated that signaling from hyaluronan degradation products involves CD44 exclusively.

Go back
305.0, 1125.0
30.0, 30.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e12 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c44 : 1
stoichiometry:c25 : 1

m12*m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
333.0, 1173.0
30.0, 30.0

p16

p16

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e13 e24

MO000017264

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c45 : 1
stoichiometry:c27 : 1

m13*m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
465.0, 1269.0
29.0, 29.0

p17

p17

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e14 e24

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c46 : 1
stoichiometry:c28 : 1

m14*m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
495.0, 1171.0
25.0, 25.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c29 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
522.0, 1094.0
26.0, 26.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e24

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c30 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
405.0, 913.0
23.0, 23.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

G010417

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c23 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
849.0, 101.0
30.0, 30.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e27 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c49 : 1
stoichiometry:c51 : 1

m27*m28*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
893.0, 937.0
30.0, 30.0

p21

p21

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e19

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c67 : 1
stoichiometry:c47 : 1

m93423*m19*0.1

nodelay

--

true

0

false

PMID: 18243041 In these same studies, stimulation of T cells with elastin peptides resulted in interferon gamma release that correlated with the severity of emphysema.

Go back
630.0, 1022.0
27.0, 27.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G010279

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c55 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
585.0, 1289.0
27.0, 27.0

p23

p23

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

G010279 e29

MO000021957

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c64 : 1
stoichiometry:c56 : 1

m93262*m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
539.0, 1287.0
25.0, 25.0

p24

p24

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G024078 e29

MO000062812

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c59 : 1

m102788*m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
575.0, 1043.0
25.0, 25.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G024078

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c58 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
677.0, 1041.0
23.0, 23.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c48 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
729.0, 1029.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c69 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
757.0, 981.0
25.0, 25.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
659.0, 1275.0
25.0, 25.0

p29

p29

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e21 e29

MO000000214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c73 : 1
stoichiometry:c54 : 1

m21*m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
424.0, 980.0
23.0, 23.0

p3

p3

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c4 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
873.0, 1037.0
30.0, 30.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e29

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c74 : 1
stoichiometry:c70 : 1

m93248*m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
893.0, 985.0
30.0, 30.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e29

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c76 : 1

m93309*m29*0.1

nodelay

--

true

0

false

PMID: 18243041, 1740645, 7696347, 17327485 Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).

Go back
727.0, 1055.0
25.0, 25.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

G010279

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c80 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
784.0, 1076.0
23.0, 23.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

G010422

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
1017.0, 1117.0
30.0, 30.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e22 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m22*m30*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
1017.0, 1217.0
30.0, 30.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e32 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
775.0, 1099.0
25.0, 25.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010279

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c90 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
740.0, 1160.0
23.0, 23.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010861

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c92 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
725.0, 1237.0
29.0, 29.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010861 e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c94 : 1

m93747*m34*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
625.0, 1305.0
23.0, 23.0

p39

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010279 e34

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m93262*m34*0.1

nodelay

--

true

0

false

PMID: 18243041, 12817023, 7737965, 12817023 Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.

Go back
438.0, 1026.0
27.0, 27.0

p4

p4

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c5 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
760.0, 1012.0
24.0, 24.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18243041, 15661925 Additional studies using microarray analysis indicated that this laminin alpha5-derived peptide up-regulates many genes, including the pro-inflammatory cytokine TNFalpha and one of its receptors, TNFR-II.

Go back
757.0, 1129.0
23.0, 23.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18243041, 15661925 Additional studies using microarray analysis indicated that this laminin alpha5-derived peptide up-regulates many genes, including the pro-inflammatory cytokine TNFalpha and one of its receptors, TNFR-II.

Go back
577.0, 729.0
30.0, 30.0

p42

p42

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000058 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m38*m37*0.1

nodelay

--

true

0

false

PMID: 18243041, 15860743 Using melanoma cells as the target cell and induction of IL-1beta as the readout Debret et al. found that VGVAPG induced NF-kappaB translocation and DNA binding.

Go back
637.0, 809.0
30.0, 30.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e38 e5 e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m39*m5*m37*0.1

nodelay

--

true

0

false

--

Go back
459.0, 1075.0
25.0, 25.0

p5

p5

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e24

G010815

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c6 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
261.0, 981.0
30.0, 30.0

p6

p6

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e6 e24

MO000019886

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c41 : 1
stoichiometry:c1 : 1

m6*m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
269.0, 1029.0
30.0, 30.0

p7

p7

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e11 e24

MO000019951

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c42 : 1
stoichiometry:c2 : 1

m11*m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
273.0, 1081.0
30.0, 30.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010815 e24

MO000017280

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c43 : 1
stoichiometry:c3 : 1

m93710*m24*0.1

nodelay

--

true

0

false

PMID: 18243041, 10201943, 11000131, 8941660 low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.

Go back
171.0, 78.0
30.0, 30.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000036944

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m15*m15253*0.1

nodelay

--

true

0

false

PMID: 18243041 The identity of this receptor protein, commonly called the elastin-binding protein (EBP), has been established as an enzymatically inactive, alternatively spliced variant of beta-galactosidase. PMID: 18243041 This protein binds the X-Gly-X-X-Pro-Gly (XGXXPG) motif in ECM proteins, such as elastin, laminins, collagen type IV, and fibrillin-1.

Go back
258.2065506721577, 956.3292586792176

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
151.0, 100.64280339782485

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.6568542494924, 1041.6568542494924

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.9822812628529, 1142.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
787.4544095119727, 1147.9037525424544

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
610.2809168618294, 696.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.0, 759.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
615.0, 744.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
608.0, 818.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 844.802450327407

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 834.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
674.8182600767711, 749.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
185.0, 115.99876913608011

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.0, 108.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
254.0, 195.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 247.99783754557475

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 209.93822301370935

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
303.0, 185.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 195.57753753315023

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
334.0, 240.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.0, 1104.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.1192895849364, 1021.1530859662622

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.3965687990774, 136.90567906314124

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 116.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 131.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
394.9876828256433, 926.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.99632943316306, 1137.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.0, 1140.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.99939040652174, 1139.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
293.0, 1188.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
422.96029752167993, 1278.796029752168

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
483.9889426346601, 1185.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.76391122424775, 1079.2719439311038

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.0, 1120.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.99945922195496, 1187.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
498.34500298894307, 1220.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
498.0, 204.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
418.84156687401844, 204.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
437.586049996169, 204.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
453.4082265953242, 204.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
472.21117782086674, 204.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
492.0348201271907, 204.0

c38

c38

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.0, 204.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 992.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.0, 204.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
282.0872722011422, 204.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.9025871463881, 204.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
292.7787343792323, 204.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.44386279480096, 204.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
351.1599538902469, 204.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.1201742322433, 204.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 919.2987830845308

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.5320828753572, 1064.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
815.0, 137.0115218004042

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.9822812628529, 1042.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
887.0, 116.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 131.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.0, 915.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.0, 952.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.0, 1300.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.5460518241941, 1049.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 1316.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.2532966642152, 1144.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.8074497210199, 1068.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 1312.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 1088.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.4704480258948, 1164.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
594.4055353784671, 212.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.143739276003, 212.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
649.9897645329472, 212.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
603.836344093983, 212.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
662.0, 1213.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
692.5798431065099, 212.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.0, 51.565538456608806

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
396.0, 68.02122632579187

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
752.0, 1033.8975234928632

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.99597180236293, 993.0

c7

c7

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
903.0, 1053.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
842.0, 1037.0

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.1245841508614, 212.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.3644699294236, 212.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.0, 212.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.9197385224488, 212.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
923.0, 1001.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 990.9531617649475

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.0, 990.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.0, 212.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
307.0, 1044.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.0385665808595, 1075.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.9021037226325, 1127.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
973.0, 1140.8831942336174

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
987.1165361451483, 1109.654437479941

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.9256926368353, 1071.0878401658401

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
814.9820434321972, 1089.5357076128992

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
754.4822900596503, 1093.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1054.72987951681, 1225.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 1246.223472969005

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
983.7721627102651, 1220.8956494415281

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
310.98563876372623, 1089.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.9510698773889, 1113.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
806.8838031123112, 1123.0759360533423

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.6749240125702, 1175.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.8266363423409, 1175.656430971924

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
747.0, 1266.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
715.0, 1199.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
761.8975240392217, 1218.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
627.0, 1144.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
655.6429631447422, 1220.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
784.0, 1002.7551284886705

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back