_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e2
_enti_e3
_enti_e4
_enti_e55
_enti_e59
_enti_e53
_enti_e50
_enti_e54
_enti_e52
_enti_e51
_enti_e56
_enti_e58
_enti_e57
_enti_e61
_enti_e60
_enti_e62
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g1
p1_propro_p1
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c33 cso30:c:InputAssociation connector
c19 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c34 cso30:c:InputAssociation connector
c23 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c35 cso30:c:InputAssociation connector
c4 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c36 cso30:c:InputAssociation connector
c5 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c37 cso30:c:InputAssociation connector
c6 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c7 cso30:c:InputAssociation connector
c41 cso30:c:InputAssociation connector
c1 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c8 cso30:c:InputAssociation connector
c42 cso30:c:InputAssociation connector
c2 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c9 cso30:c:InputAssociation connector
c43 cso30:c:InputAssociation connector
c3 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18243041
The identity of this receptor protein, commonly called the elastin-binding protein (EBP), has been established as an enzymatically inactive, alternatively spliced variant of beta-galactosidase.
PMID: 18243041
This protein binds the X-Gly-X-X-Pro-Gly (XGXXPG) motif in ECM proteins, such as elastin, laminins, collagen type IV, and fibrillin-1.
c10 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 18243041
EBP complexes with the 55-kDa protective protein-cathepsin A (PPCA) and the 61-kDa neuraminidase (Neu-1) on the cell surface.
c13 cso30:c:InputProcess connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p11_propro_p11
PMID: 18243041
EBP complexes with the 55-kDa protective protein-cathepsin A (PPCA) and the 61-kDa neuraminidase (Neu-1) on the cell surface.
c16 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c17 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
PMID: 18243041
Initial studies indicated that signaling from hyaluronan degradation products involves CD44 exclusively.
c21 cso30:c:InputProcess connector
c20 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c38 cso30:c:InputAssociation connector
c24 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c26 cso30:c:InputAssociation connector
c44 cso30:c:InputAssociation connector
c25 cso30:c:OutputProcess connector
p16_propro_p16
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c31 cso30:c:InputAssociation connector
c45 cso30:c:InputAssociation connector
c27 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c32 cso30:c:InputAssociation connector
c46 cso30:c:InputAssociation connector
c28 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c39 cso30:c:InputAssociation connector
c29 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 18243041, 10201943, 11000131, 8941660
low molecular weight fragments of hyaluronan increase the expression of matrix metalloproteinase (MMP)-12, plasminogen activator inhibitor (PAI)-1 and stimulate the production of several cytokines, including MIP-1alpha, MIP-1beta, MCP-1, KC, IL-8, and IL-12 by macrophages.
c40 cso30:c:InputAssociation connector
c30 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c50 cso30:c:InputProcess connector
c49 cso30:c:InputProcess connector
c51 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 18243041
In these same studies, stimulation of T cells with elastin peptides resulted in interferon gamma release that correlated with the severity of emphysema.
c53 cso30:c:InputAssociation connector
c67 cso30:c:InputAssociation connector
c47 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 18243041
In these same studies, stimulation of T cells with elastin peptides resulted in interferon gamma release that correlated with the severity of emphysema.
c68 cso30:c:InputAssociation connector
c52 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c63 cso30:c:InputAssociation connector
c55 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c57 cso30:c:InputAssociation connector
c64 cso30:c:InputAssociation connector
c56 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c60 cso30:c:InputAssociation connector
c62 cso30:c:InputAssociation connector
c59 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c61 cso30:c:InputAssociation connector
c58 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c66 cso30:c:InputAssociation connector
c48 cso30:c:OutputProcess connector
p27_propro_p27
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c72 cso30:c:InputAssociation connector
c69 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c75 cso30:c:InputAssociation connector
c77 cso30:c:OutputProcess connector
p29_propro_p29
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c65 cso30:c:InputAssociation connector
c73 cso30:c:InputAssociation connector
c54 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c71 cso30:c:InputAssociation connector
c74 cso30:c:InputAssociation connector
c70 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 18243041, 1740645, 7696347, 17327485
Several fibronectin-derived fragments increase monocyte/macrophage secretion of proteases (e.g., MMP-9/gelatinase B, MMP-12/macrophage elastase) and pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNFalpha).
c78 cso30:c:InputAssociation connector
c79 cso30:c:InputAssociation connector
c76 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c84 cso30:c:InputAssociation connector
c80 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c85 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p34_propro_p34
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c81 cso30:c:InputProcess connector
c82 cso30:c:InputProcess connector
c83 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c87 cso30:c:InputProcess connector
c88 cso30:c:InputProcess connector
c89 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c91 cso30:c:InputAssociation connector
c90 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c93 cso30:c:InputAssociation connector
c92 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c95 cso30:c:InputAssociation connector
c96 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 18243041, 12817023, 7737965, 12817023
Peptides containing the SIKVAV sequence of laminin-111 induce the expression of MMP-9 and urokinase-type plaminogen activator (uPA) by monocytes/macrophages, and a similar peptide (ASKVKV) derived from laminin-511 induces MMP-9 and MMP-14/MT1-MMP production by monocytes and macrophages.
c97 cso30:c:InputAssociation connector
c98 cso30:c:InputAssociation connector
p40_propro_p40
PMID: 18243041, 15661925
Additional studies using microarray analysis indicated that this laminin alpha5-derived peptide up-regulates many genes, including the pro-inflammatory cytokine TNFalpha and one of its receptors, TNFR-II.
c100 cso30:c:InputAssociation connector
c99 cso30:c:OutputProcess connector
p41_propro_p41
PMID: 18243041, 15661925
Additional studies using microarray analysis indicated that this laminin alpha5-derived peptide up-regulates many genes, including the pro-inflammatory cytokine TNFalpha and one of its receptors, TNFR-II.
c102 cso30:c:InputAssociation connector
c101 cso30:c:OutputProcess connector
p42_propro_p42
PMID: 18243041, 15860743
Using melanoma cells as the target cell and induction of IL-1beta as the readout Debret et al. found that VGVAPG induced NF-kappaB translocation and DNA binding.
c103 cso30:c:InputProcess connector
c105 cso30:c:InputAssociation connector
c104 cso30:c:OutputProcess connector
p43_propro_p43
c106 cso30:c:InputProcess connector
c107 cso30:c:InputProcess connector
c109 cso30:c:InputAssociation connector
c108 cso30:c:OutputProcess connector
EBP_enti_MO000036944
EBP
MMP12_enti_G024078
MMP12
PAI-1_enti_G010417
PAI-1
MIP-1alpha_enti_e6
MIP-1alpha
MIP-1beta_enti_MO000019951
MIP-1beta
MIP-1alpha_enti_MO000019886
MIP-1alpha
MIP-1beta_enti_e11
MIP-1beta
MCP-1_enti_MO000017280
MCP-1
MCP1_enti_G010815
MCP1
KC_enti_e12
KC
IL-8_enti_MO000017264
IL-8
IL8_enti_e13
IL8
IL12_enti_e14
IL12
IL-12_enti_MO000017265
IL-12
XGXXPG_enti_e15
XGXXPG
XGXXPG: EBP_enti_e16
XGXXPG: EBP
PPCA_enti_e17
PPCA
XGXXPG: EBP: PPCA_enti_e18
XGXXPG: EBP: PPCA
XGXXPG: EBP: PPCA: NEU1_enti_e19
XGXXPG: EBP: PPCA: NEU1
NEU1_enti_e20
NEU1
hyaluronan fragment_enti_e23
hyaluronan fragment
hyaluronan fragment: CD44_enti_e24
hyaluronan fragment: CD44
KC_enti_e25
KC
IFNgamma_enti_e26
IFNgamma
fibronectin fragmant_enti_e27
fibronectin fragmant
fibronectin fragmant : fibronectin fragment recptor_enti_e29
fibronectin fragmant : fibronectin fragment recptor
IFN-gamma_enti_G010453
IFN-gamma
MMP9_enti_MO000021957
MMP9
MMP-9_enti_G010279
MMP-9
MMP12_enti_MO000062812
MMP12
CD44_enti_MO000002553
CD44
IL-1_enti_MO000000214
IL-1
fibronectin fragment recptor_enti_e28
fibronectin fragment recptor
IL-1_enti_e21
IL-1
IL-6_enti_G010262
IL-6
IL-6_enti_MO000007384
IL-6
TNF-alpha_enti_G010329
TNF-alpha
TNF-alpha_enti_MO000000289
TNF-alpha
uPA_enti_G010422
uPA
SIKVAV_enti_e22
SIKVAV
SIKVAV receptor_enti_e30
SIKVAV receptor
SIKVAV :SIKVAV receptor_enti_e31
SIKVAV :SIKVAV receptor
ASKVKV_enti_e32
ASKVKV
ASKVKV receptor_enti_e33
ASKVKV receptor
ASKVKV: ASKVKV receptor_enti_e34
ASKVKV: ASKVKV receptor
MMP14_enti_G010861
MMP14
MT1-MMP_enti_e35
MT1-MMP
TNFR-II_enti_e36
TNFR-II
VGVAPG_enti_e37
VGVAPG
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB_enti_e38
NF-kappaB
DNA_enti_e5
DNA
NF-kappaB_DNA_enti_e39
NF-kappaB_DNA