1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18249034.csml convertedTime:2009.07.01.11:14

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Sweet preferences of MGL: carbohydrate specificity and function.
Authors van Vliet SJ, Saeland E, van Kooyk Y.
Affiliation Department of Molecular Cell Biology and Immunology, VU University MedicalCenter, Amsterdam, The Netherlands.
Abstract C-type lectins play important roles in both innate and adaptive immuneresponses. In contrast to the mannose- or fucose-specific C-type lectins DC-SIGNand mannose receptor, the galactose-type lectins, of which only macrophagegalactose-type lectin (MGL) is found within the immune system, are less wellknown. MGL is selectively expressed by immature dendritic cells and macrophageswith elevated levels on tolerogenic or alternatively activated subsets. HumanMGL has an exclusive specificity for rare terminal GalNAc structures, which arerevealed on the tumor-associated mucin MUC1 and CD45 on effector T cells. Thesefindings implicate MGL in the homeostatic control of adaptive immunity. Wediscuss here the functional similarities and differences between MGL orthologsand compare MGL to its closest homolog, the liver-specific asialoglycoproteinreceptor (ASGP-R).
PMID 18249034
Model Abstract

Entity

e1: e10: e11:DC-SIGN:Mannose e12:MR e13:Mannose:MR e14:Fucose e15:DC-SIGN:Fucose e16:Ca2+ e17:rMGL e18:Galactose e19:rMGL:Galactose e2: e20:MGL e21:Glycoproteins e22:MGL:Glycoproteins e23:Glycosphingolipids e24:MGL:Glycosphingolipids e25:Glycans e26:MGL:Glycans e27:MUC1 e28:MGL:MUC1 e29:GM1 e3: e30:MGL:GM1 e31:GD2 e32:MGL:GD2 e33:ASGP-R e34:Tri-antennary glycans e35:ASGP-R:Tri-antennary glycans e36:tetra-antennary glycans e37:ASGP-R:Tetra-antennary glycans e38:sialoadhesin e39:mMGL e4: e40:mMGL:sialoadhesin e41:CD45ABC e42:MGL:CD45ABC e43:CD45AB e44:MGL:CD45AB e45:CD45BC e46:MGL:CD45BC e47:CD45B e49:CD45B:MGL e5:DC-SIGN e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Mannose e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p2 p3 p4 p5 p6 p7 p8 p9
Model Detail
221.60841950076602, 175.8091726347477
764.4010116756867, 1240.4764294425784

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
225.97337002476775, 185.76928046303095
740.9386601455254, 1164.9041677257896

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
417.5, 179.0
21.97390923043192, 42.53014689761018

DC-SIGN:Mannose

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
240.5, 191.0
22.481546572934974, 34.58699472759227

MR

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
233.5, 264.0
20.71650953738215, 40.09647007235256

Mannose:MR

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
506.0, 99.0
44.407064760302774, 25.164003364171574

Fucose

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
529.5, 184.0
20.519403639552728, 39.71497478623108

DC-SIGN:Fucose

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
389.5, 325.0
21.863578590594543, 22.234147719248686

Ca2+

--

e16

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1 p2 p3

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
608.5, 191.0
22.413005272407734, 34.481546572934974

rMGL

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
662.0, 88.0
43.92767031118588, 24.892346509671988

Galactose

--

e18

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
672.5, 178.0
22.245779434334576, 43.056347292260476

rMGL:Galactose

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
221.60841950076602, 175.8091726347477
764.4010116756867, 1240.4764294425784

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
748.5, 190.0
20.859402460456945, 32.09138840070299

MGL

--

e20

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5 p6 p7 p8 p9 p10 p14 p15 p16 p17

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
771.0, 84.5
25.57456228617428, 15.77098007647414

Glycoproteins

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
814.5, 173.0
19.581451436088578, 37.89958342468758

MGL:Glycoproteins

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
895.0, 82.5
25.759999999999994, 19.319999999999997

Glycosphingolipids

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
938.5, 189.0
19.751370313527733, 38.228458671344

MGL:Glycosphingolipids

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
1040.5, 320.0
15.05614811833367, 24.41537532702757

Glycans

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
936.5, 271.0
22.02828327121245, 42.63538697654023

MGL:Glycans

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
1061.0, 386.5
29.91212653778559, 19.44288224956063

MUC1

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
936.5, 374.0
22.701162025871515, 43.93773295329971

MGL:MUC1

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1088.0, 434.0
15.760523854069222, 36.37043966323667

GM1

--

e29

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
236.8964397342797, 192.89562483092652
733.8249712086593, 1206.3035250502219

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
936.5, 475.0
22.041876781407584, 42.661696996272745

MGL:GM1

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
1088.0, 518.0
15.60243217960711, 36.00561272217024

GD2

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
938.5, 549.0
19.404735803551855, 37.55755316816488

MGL:GD2

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
228.5, 354.0
23.578207381370824, 36.274165202108954

ASGP-R

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11 p12

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
151.0, 295.5
26.99939625679211, 16.64962769168847

Tri-antennary glycans

--

e34

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
225.5, 423.0
21.674852006139005, 41.951326463494844

ASGP-R:Tri-antennary glycans

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
152.0, 551.5
23.04, 17.279999999999994

tetra-antennary glycans

--

e36

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
229.5, 515.0
21.396185047138783, 41.411971058978295

ASGP-R:Tetra-antennary glycans

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
932.5, 614.0
23.943760984182774, 36.83655536028119

sialoadhesin

--

e38

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
935.5, 692.0
25.977152899824254, 39.96485061511424

mMGL

--

e39

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
265.17927716628026, 222.79691617423921
677.2592963446587, 1146.5009423635952

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
936.5, 762.0
22.887352107982, 28.025329111814695

mMGL:sialoadhesin

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
232.5, 607.0
22.550087873462218, 34.692442882249566

CD45ABC

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p14

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
232.5, 666.0
22.577070488251966, 27.64539243459424

MGL:CD45ABC

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
232.5, 727.0
22.481546572934974, 34.58699472759228

CD45AB

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
223.5, 788.0
25.941176470588232, 31.76470588235295

MGL:CD45AB

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
224.5, 855.0
22.481546572934974, 34.58699472759228

CD45BC

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
236.5, 914.0
22.22596233961006, 27.21546408931845

MGL:CD45BC

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
944.5, 859.0
22.481546572934974, 34.58699472759228

CD45B

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
941.5, 919.0
21.14814197633728, 25.8956840526579

CD45B:MGL

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
325.5, 195.0
21.47627416520211, 33.04042179261863

DC-SIGN

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1 p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
376.41415070989433, 753.1904350041643
415.6957253609598, 421.3382442512506

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
421.312385478862, 763.175538863458
243.06975374923914, 408.36068025993893

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
381.8329031820112, 758.814046067066
404.85822041672645, 410.09102212544707

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
382.6070106780278, 759.67921699982
403.3100054246929, 408.36068025993893

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
376.41415070989433, 753.1904350041643
415.6957253609598, 421.3382442512506

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
376.41415070989433, 753.1904350041643
415.6957253609598, 421.3382442512506

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
382.6070106780278, 759.67921699982
403.3100054246929, 408.36068025993893

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
679.8642891484348, 926.2246215549858
25.970384878696283, 26.27567484060242

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
611.7428294989664, 1047.348552140561
73.54021212158504, 74.40470021685334

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
376.41415070989433, 753.1904350041643
415.6957253609598, 421.3382442512506

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
300.0, 114.0
48.69638351555929, 27.5946173254836

Mannose

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1 p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
474.39129421862003, 940.4296692028463
13.164472821474048, 7.084084084604015

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
473.9516952079966, 919.303254092953
45.0588985888957, 90.64706018082182

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
492.85445266480195, 978.2606916089351
7.033584169973956, 7.860991668797554

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
222.6515338516774, 180.80094785045807
749.6392443348609, 1187.175416181928

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
225.32969767858714, 201.7534467693174
719.1378596195282, 1167.023003308494

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
232.4714678836797, 222.70594568817668
715.8546008185155, 1151.7177890496082

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
401.0, 117.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e5 e16

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c11 : 1
stoichiometry:c3 : 1

m6*m5*m16*0.1

nodelay

--

true

0

false

PMID: 18249034,15032573 In particular, mannose- and fucose-specific CLRs, such as dendritic cell-specific intercellular-grabbing nonintegrin (DC-SIGN) and the mannose receptor (MR), are well characterized on the basis of their carbohydrate specificity and function within the immune system PMID: 18249034 Within the last few years, numerous C-type lectin receptors (CLRs), which recognize carbohydrate structures in a Ca2+-dependent manner, have been identified

Go back
1009.0, 513.0
22.0, 22.0

p7

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e20

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m31*m20*0.1

nodelay

--

true

0

false

PMID: 18249034,17195076,15802303 Specific glycans containing terminal GalNAc moieties, expressed by the human helminth parasite Schistosoma mansoni as well as by the tumor antigen MUC1 and the gangliosides GM2 and GD2, were identified as ligands for MGL

Go back
154.0, 362.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m34*m33*0.1

nodelay

--

true

0

false

PMID: 18249034,15262963,7496141 Whereas MGL recognizes only GalNAc structures, ASGP-R preferentially interacts with tri- or tetra-antennary glycans containing both galactose or GalNAc residues

Go back
154.0, 482.0
19.0, 19.0

p11

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e33 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m33*m36*0.1

nodelay

--

true

0

false

PMID: 18249034,15262963,7496141 Whereas MGL recognizes only GalNAc structures, ASGP-R preferentially interacts with tri- or tetra-antennary glycans containing both galactose or GalNAc residues

Go back
1022.0, 702.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m38*m39*0.1

nodelay

--

true

0

false

PMID: 18249034,15364954 The macrophagespecific receptor sialoadhesin has been identified as a selfligand for mMGL1, and it probably regulates the cellular localization of mMGL1pos cells within LNs

Go back
305.0, 613.0
21.0, 21.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m20*m41*0.1

nodelay

--

true

0

false

PMID: 18249034 MGL recognizes all CD45 isoforms, except CD45RO.

Go back
301.0, 733.0
21.0, 21.0

p14

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m20*m43*0.1

nodelay

--

true

0

false

PMID: 18249034 MGL recognizes all CD45 isoforms, except CD45RO.

Go back
305.0, 805.0
21.0, 21.0

p14

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c49 : 1
stoichiometry:c51 : 1

m20*m45*0.1

nodelay

--

true

0

false

PMID: 18249034 MGL recognizes all CD45 isoforms, except CD45RO.

Go back
862.0, 866.0
20.0, 20.0

p14

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 e20

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m47*m20*0.1

nodelay

--

true

0

false

PMID: 18249034 MGL recognizes all CD45 isoforms, except CD45RO.

Go back
169.0, 197.0
21.0, 21.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 e12 e16

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c10 : 1
stoichiometry:c6 : 1

m6*m12*m16*0.1

nodelay

--

true

0

false

PMID: 18249034,15032573 In particular, mannose- and fucose-specific CLRs, such as dendritic cell-specific intercellular-grabbing nonintegrin (DC-SIGN) and the mannose receptor (MR), are well characterized on the basis of their carbohydrate specificity and function within the immune system PMID: 18249034 Within the last few years, numerous C-type lectin receptors (CLRs), which recognize carbohydrate structures in a Ca2+-dependent manner, have been identified

Go back
461.0, 129.0
21.0, 21.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e14 e16

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c12 : 1
stoichiometry:c9 : 1

m5*m14*m16*0.1

nodelay

--

true

0

false

PMID: 18249034,15032573 In particular, mannose- and fucose-specific CLRs, such as dendritic cell-specific intercellular-grabbing nonintegrin (DC-SIGN) and the mannose receptor (MR), are well characterized on the basis of their carbohydrate specificity and function within the immune system PMID: 18249034 Within the last few years, numerous C-type lectin receptors (CLRs), which recognize carbohydrate structures in a Ca2+-dependent manner, have been identified

Go back
610.0, 130.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 e17

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m18*m17*0.1

nodelay

--

true

0

false

PMID: 18249034,3768888 In the 1980s, Kawasaki et al. discovered that rat peritoneal macrophages expressed a Ca2+-dependent lectin, distinct from the hepatic ASGP-R, with specificity for galactose and GalNAc PMID: 18249034,2358462 Based on its binding properties, the lectin was isolated and characterized as rat MGL (rMGL) or macrophage asialoglycoprotein-binding protein (M-ASGP-BP)

Go back
749.0, 133.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e21

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m20*m21*0.1

nodelay

--

true

0

false

PMID: 18249034 MGL displays an exclusive specificity for terminal a- and b-linked GalNAc residues that naturally occur on glycoproteins or glycosphingolipids

Go back
881.0, 137.0
21.0, 21.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m20*m23*0.1

nodelay

--

true

0

false

PMID: 18249034 MGL displays an exclusive specificity for terminal a- and b-linked GalNAc residues that naturally occur on glycoproteins or glycosphingolipids

Go back
1021.0, 245.0
22.0, 22.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m20*m25*0.1

nodelay

--

true

0

false

PMID: 18249034,17195076,15802303 Specific glycans containing terminal GalNAc moieties, expressed by the human helminth parasite Schistosoma mansoni as well as by the tumor antigen MUC1 and the gangliosides GM2 and GD2, were identified as ligands for MGL

Go back
997.0, 345.0
22.0, 22.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m20*m27*0.1

nodelay

--

true

0

false

PMID: 18249034,17195076,15802303 Specific glycans containing terminal GalNAc moieties, expressed by the human helminth parasite Schistosoma mansoni as well as by the tumor antigen MUC1 and the gangliosides GM2 and GD2, were identified as ligands for MGL

Go back
1001.0, 441.0
22.0, 22.0

p7

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m20*m29*0.1

nodelay

--

true

0

false

PMID: 18249034,17195076,15802303 Specific glycans containing terminal GalNAc moieties, expressed by the human helminth parasite Schistosoma mansoni as well as by the tumor antigen MUC1 and the gangliosides GM2 and GD2, were identified as ligands for MGL

Go back
349.0, 128.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
196.92024951409442, 218.01374471817476

c10

c10

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
401.0, 145.98858577206613

c11

c11

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
404.0, 157.51332064000624

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
635.8063839788744, 113.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
620.0, 157.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.0, 148.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.0, 161.99691536522175

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.3104235544095, 100.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 151.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 156.15135438863334

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.0, 143.9368211420091

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.197769023179, 102.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
901.0, 158.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 208.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.6257316546619, 274.833070699734

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
966.3346783915133, 261.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 212.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.8743430752777, 366.09187087814144

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.6833366579515, 363.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 216.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1031.0, 452.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
414.0, 138.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
965.5831752048196, 460.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1038.9021037226325, 527.247700587784

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.0, 219.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.8361755317706, 531.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
164.0, 312.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
181.0, 372.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
173.0, 381.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.3186590790551, 390.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
164.0, 509.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
173.0, 497.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.99625623383145, 141.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 643.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
961.0, 712.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
965.4121929822057, 720.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
331.8195379163431, 216.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.0, 624.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.3080184481423, 632.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
326.11912192390065, 219.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.0, 744.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.3409919128368, 753.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
247.0, 828.5418636464293

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
198.0, 208.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.70208375734506, 220.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.12741261797026, 826.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.0, 876.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
762.0, 222.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.0, 883.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
189.0, 218.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
347.0, 149.72597146266097

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.1554175279993, 123.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
482.0, 149.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back