1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18249132.csml convertedTime:2009.07.01.11:14

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title The involvement of the interleukin-1 receptor-associated kinases (IRAKs) incellular signaling networks controlling inflammation.
Authors Ringwood L, Li L.
Affiliation The Laboratory of Innate Immunity and Inflammation, Department of BiologicalSciences, West Campus Drive, Fralin Biotechnology Center, Virginia Tech,Blacksburg, VA 24061, USA.
Abstract Innate immunity and inflammation plays a key role in host defense and woundhealing. However, Excessive or altered inflammatory processes can contribute tosevere and diverse human diseases including cardiovascular disease, diabetes andcancer. The interleukin-1 receptor-associated kinases (IRAKs) are criticallyinvolved in the regulation of intracellular signaling networks controllinginflammation. Collective studies indicate that IRAKs are present in many celltypes, and can mediate signals from various cell receptors includingtoll-like-receptors (TLRs). Consequently, diverse downstream signaling processescan be elicited following the activation of various IRAKs. Given the criticaland complex roles IRAK proteins play, it is not surprising that geneticvariations in human IRAK genes have been found to be linked with various humaninflammatory diseases. This review intends to summarize the recent advancesregarding the regulations of various IRAK proteins and their cellular functionsin mediating inflammatory signaling processes.
PMID 18249132
Model Abstract

Entity

e1: e10: e100:TCR ligand:TCR:Zap-70:IRAK-4 e101:Zap-70 e102:PKC{active} e103:PKC e11:TAK1 e12:TLR ligand:TLR e13:TLR e14:TLR ligand e15:MYD88 e16:TLR ligand:TLR:MYD88 e17:IRAK-1 e18:Tollip e19:TRAF e2: e20:TLR ligand:TLR:MYD88:IRAK-1:TRAF:Tollip:IRAK4 e21:IkappaB-alpha:p50:p65 e22:IkappaB-alpha:p50:p65 e23:IKK complex e24:protein remnants e25:p50:p65 e26:p50:p65{p} e27:IKK-epsilon e28:IKK-epsilon e29:p50:p65{p} e3: e30:IRF-5 e31:IRF-5{p} e32:IRF-7{p} e33:IRF-7 e34:TNF-alpha e36:IFNA4 e37:IRAK-1{active} e38:TLR7 ligand e39:TLR9 ligand e4: e40:TLR8 ligand e41:NF-kappaB e42:NF-kappaB{active} e43:caveolin e44:IRAK-1:caveolin e45:CD26 e46:CD86 e47:IRAK-4 e48:TLR ligand:TLR:MYD88:IRAK-1{p}:TRAF:Tollip:IRAK4 e49:TLR ligand:TLR:MYD88:TRAF:Tollip:IRAK4 e5:P47phox e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:p47phox{p} e60: e61: e62: e63:TLR ligand:TLR:MYD88:IRAK-1{p}:TRAF:Tollip:IRAK4 e64:TLR ligand:TLR:MYD88:IRAK-1{p}{ub}:TRAF:Tollip:IRAK4 e65:LPS:TLR4 e66:TLR4 e67:LPS e68:LPS:TLR4:MYD88:IRAK4:IRAK1 e69:LPS:TLR4:MYD88:IRAK4:IRAK1 e7: e70:IRAK-1{sumo} e71:LPS:TLR4:MYD88:IRAK4 e72:Stat3 e73:Stat3{active} e74:gene e75:IL-1beta e76:MAPK e77:MAPK{active} e78:IRAK-1c e79:IRAK-2 e8: e80:TRAF6 e81:TLR ligand:TLR:MYD88:IRAK-2:TRAF6:IRAK4 e82:Mal e83:TLR ligand:TLR:MAL:IRAK2 e84:TLR ligand:TLR:MYD88:IRAK-2:TRAF6{ub}:IRAK4 e85:IRAK-2a e86:IRAK-2b e87:IRAK-2c e88:IRAK-2d e89:TAK1{active} e9: e90:IKK complex e91:NIK e92:NIK{active} e93:IRAK-M e94:IkappaB-alpha e95:IkappaB-alpha e96:IkappaB-alpha e97:IkappaB-alpha:p50:p65 e98:inflammatory mediators e99:TCR ligand:TCR

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p6 p7 p8 p9
Model Detail
39.146739851836614, 110.09783476429186
1199.856727218067, 1742.1919679206312

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
50.70727587530395, 136.72643228160825
1163.0285965774399, 1636.0542096887002

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
75.0, 731.2352941176471
25.05882352941176, 41.76470588235294

TCR ligand:TCR:Zap-70:IRAK-4

--

e100

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p49

p50 p51

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
150.0, 556.6849466693499
36.997383779432475, 22.815053330650027

Zap-70

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
141.5, 902.9851076675388
20.975850271684443, 34.014892332461265

PKC{active}

--

e102

cso30:c:Protein

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
141.5, 786.9851076675388
20.975850271684443, 34.014892332461265

PKC

--

e103

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
143.0, 710.1049506943048
33.07305292815456, 20.39504930569531

TAK1

--

e11

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p40

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
752.5, 133.57553168164876
22.952641964481476, 44.42446831835123

TLR ligand:TLR

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3 p33 p36

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
696.5, 141.12829525483312
23.96660808435852, 36.871704745166966

TLR

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
740.0, 9.54920913884007
32.23198594024605, 20.95079086115993

TLR ligand

--

e14

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
765.0, 212.82
30.23999999999999, 22.68

MYD88

--

e15

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p3 p27 p33

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
864.5, 139.71315837768395
23.855569829326484, 33.28684162231602

TLR ligand:TLR:MYD88

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
832.0, 260.66510757717487
16.61178671655753, 38.33489242282507

IRAK-1

--

e17

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4 p14 p15 p20 p27

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
917.5, 263.190380358221
20.849265445763734, 33.80961964177904

Tollip

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
830.0, 213.20617830549406
36.15214328838801, 22.293821694505944

TRAF

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
39.146739851836614, 110.09783476429186
1199.856727218067, 1742.1919679206312

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
970.0, 135.5
19.5, 32.5

TLR ligand:TLR:MYD88:IRAK-1:TRAF:Tollip:IRAK4

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p8 p10 p11 p22

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
758.5, 562.7933565791891
18.781427784914662, 26.206643420811165

IkappaB-alpha:p50:p65

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p5

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
758.5, 706.7933565791891
18.781427784914662, 26.206643420811165

IkappaB-alpha:p50:p65

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5 p47

p6

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
653.0, 637.5773286467486
30.650263620386642, 19.922671353251317

IKK complex

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

p41 p42

p5

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
679.0, 875.3641585295808
25.485353245261344, 24.635841470419297

protein remnants

--

e24

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p6 p25

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
734.0, 948.8342541436463
27.14917127071823, 30.16574585635359

p50:p65

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p7

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
813.0, 1027.303867403315
22.226519337016576, 24.69613259668509

p50:p65{p}

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p9

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
809.0, 813.3
29.599999999999998, 22.199999999999996

IKK-epsilon

--

e27

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8

p7

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
849.0, 701.3
29.599999999999998, 22.199999999999996

IKK-epsilon

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
734.0, 1180.3922651933701
27.54696132596686, 30.607734806629836

p50:p65{p}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p43 p46 p48

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
63.143874396197845, 134.09496930865328
1151.8624581293436, 1694.1976988319095

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
403.0, 821.0252565908634
34.8239082310324, 21.474743409136646

IRF-5

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
378.0, 1012.9756097560976
28.78048780487805, 23.024390243902438

IRF-5{p}

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
550.0, 989.5121951219513
35.609756097560975, 28.48780487804878

IRF-7{p}

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
551.0, 765.2114107466292
34.52203662708796, 21.2885892533709

IRF-7

--

e33

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
472.0, 1217.0173010380622
39.34256055363322, 20.98269896193772

TNF-alpha

--

e34

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
591.0, 1212.2456747404847
42.66435986159169, 22.75432525951557

IFNA4

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p13

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
636.0, 289.5070159027128
16.246959775491113, 37.49298409728718

IRAK-1{active}

--

e37

cso30:c:Protein

cso30:i:CC_Cytosol

--

p14 p15

p13

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
509.0, 41.33894028595461
38.22539949537426, 21.661059714045415

TLR7 ligand

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p15 p18

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
402.0, 58.04037005887301
35.2228763666947, 19.959629941126995

TLR9 ligand

--

e39

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p14 p17

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
107.53857330326656, 176.08995476128524
1063.073060315207, 1610.2077279266448

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
623.0, 43.95121951219515
42.4390243902439, 24.04878048780488

TLR8 ligand

--

e40

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
196.0, 956.255282753069
39.3157576977259, 24.244717246930975

NF-kappaB

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17 p18 p19 p34 p38 p39 p51

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
236.0, 1168.255282753069
39.3157576977259, 24.244717246930975

NF-kappaB{active}

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

p17 p18 p19 p34 p38 p39 p51

p12 p35 p52

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
996.0, 352.3799999999999
32.15999999999999, 24.119999999999997

caveolin

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1036.0, 519.1436464088399
23.270718232044196, 25.856353591160214

IRAK-1:caveolin

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p21

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1185.5, 403.9390219360032
20.387603139464684, 33.06097806399678

CD26

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
770.0, 1270.2318339100345
35.19031141868512, 18.7681660899654

CD86

--

e46

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p21

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
822.0, 526.2599999999999
32.32, 24.240000000000002

IRAK-4

--

e47

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1 p4 p27 p33 p49

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1072.0, 136.4705882352941
23.117647058823525, 38.52941176470589

TLR ligand:TLR:MYD88:IRAK-1{p}:TRAF:Tollip:IRAK4

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p23

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1181.0, 277.7941176470589
22.323529411764703, 37.20588235294118

TLR ligand:TLR:MYD88:TRAF:Tollip:IRAK4

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
459.0, 465.89645803984706
33.411149124572354, 20.60354196015295

P47phox

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
293.12821309467995, 1114.8178437216343
652.5047781618549, 591.7501433236939

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
363.60358950694734, 1128.8414618490112
381.5391067836544, 573.5237528722453

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
301.63386197202266, 1122.7159462505954
635.49348040717, 575.9539382657717

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
302.8489546687857, 1123.931038947358
633.0632950136429, 573.5237528722453

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
293.12821309467995, 1114.8178437216343
652.5047781618549, 591.7501433236939

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
293.12821309467995, 1114.8178437216343
652.5047781618549, 591.7501433236939

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
302.8489546687857, 1123.931038947358
633.0632950136429, 573.5237528722453

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
769.444550225866, 1357.8363830742808
40.76491334939086, 36.90297418997493

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
662.5163929107018, 1527.949360621133
115.43380619250686, 104.49797192163798

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
293.12821309467995, 1114.8178437216343
652.5047781618549, 591.7501433236939

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
573.0, 551.9999999999999
30.0, 24.000000000000004

p47phox{p}

--

e6

cso30:c:Protein

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
446.91991791574935, 1377.7867177429946
20.663867569325785, 9.949269570416131

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
446.22989288684676, 1348.1156415001738
70.72756546253899, 127.30961783257018

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
475.9009691296686, 1430.9186449685124
11.04040046244509, 11.0404004624451

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1147.0, 137.1470588235294
26.911764705882355, 44.85294117647059

TLR ligand:TLR:MYD88:IRAK-1{p}:TRAF:Tollip:IRAK4

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1178.0, 210.58823529411768
20.64705882352941, 34.411764705882355

TLR ligand:TLR:MYD88:IRAK-1{p}{ub}:TRAF:Tollip:IRAK4

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p25

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
290.5, 137.2056566542425
19.527077395308044, 37.79434334575751

LPS:TLR4

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

p27

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
200.5, 145.19859402460457
23.920913884007025, 36.801405975395426

TLR4

--

e66

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
129.0, 25.724978973927648
37.54415475189235, 21.27502102607233

LPS

--

e67

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
73.0, 230.41176470588232
21.35294117647059, 35.58823529411765

LPS:TLR4:MYD88:IRAK4:IRAK1

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
65.0, 317.3529411764706
22.588235294117652, 37.64705882352942

LPS:TLR4:MYD88:IRAK4:IRAK1

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p29

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
54.91110715656481, 117.10855296905763
1176.6856356326557, 1667.333151597564

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
399.0, 1234.7165850244928
34.28271518544437, 26.28341497550735

IRAK-1{sumo}

--

e70

cso30:c:Protein

cso30:i:CC_Cytosol

--

p29

p30

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
68.5, 500.0585428518994
22.174710956138743, 30.941457148100568

LPS:TLR4:MYD88:IRAK4

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
353.0, 1287.604303086997
14.471468662301213, 33.3956969130028

Stat3

--

e72

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p30

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
473.0, 1291.604303086997
14.471468662301213, 33.3956969130028

Stat3{active}

--

e73

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p30

p31

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
541.0, 1356.0553633217996
29.89619377162629, 15.944636678200693

gene

--

e74

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p31 p35

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
914.0, 1908.104569420035
35.99297012302285, 23.39543057996485

IL-1beta

--

e75

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p32

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
894.0, 1721.98
27.36, 20.52

MAPK

--

e76

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1054.0, 1625.8999999999999
36.800000000000004, 27.6

MAPK{active}

--

e77

cso30:c:Protein

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1043.0, 1423.77736202058
16.56314312441534, 38.22263797942002

IRAK-1c

--

e78

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
267.0, 347.61646398503274
17.49953227315248, 40.38353601496726

IRAK-2

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33 p36

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
59.11493843782566, 146.53537193788355
1128.8085513782378, 1639.030016601203

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
274.5, 284.25518212920105
19.575971020326023, 31.744817870798954

TRAF6

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
423.0, 136.38235294117658
18.97058823529412, 31.617647058823536

TLR ligand:TLR:MYD88:IRAK-2:TRAF6:IRAK4

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p37

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
529.5, 199.55484000804995
20.007848661702557, 32.4451599919501

Mal

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
69.0, 413.9411764705882
22.235294117647058, 37.05882352941176

TLR ligand:TLR:MAL:IRAK2

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
341.0, 137.67647058823536
21.794117647058826, 36.32352941176471

TLR ligand:TLR:MYD88:IRAK-2:TRAF6{ub}:IRAK4

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p34 p40 p16

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
183.0, 1466.8381665107577
18.703461178671656, 43.16183348924229

IRAK-2a

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p38

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
171.0, 1219.307764265669
17.633302151543493, 40.69223573433115

IRAK-2b

--

e86

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
231.0, 1272.0654817586528
17.304957904583723, 39.93451824134706

IRAK-2c

--

e87

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
143.0, 1163.4658559401312
17.998129092609915, 41.534144059869035

IRAK-2d

--

e88

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p39

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
207.0, 778.1049506943048
33.07305292815456, 20.39504930569531

TAK1{active}

--

e89

cso30:c:Protein

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
70.32515518785462, 175.96219090670965
1123.6549211508834, 1617.5345486372398

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
461.0, 637.5773286467486
30.650263620386642, 19.922671353251317

IKK complex

--

e90

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p41 p42

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
405.0, 520.4987925135841
37.299255383376945, 23.001207486415783

NIK

--

e91

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
365.0, 636.4987925135841
37.299255383376945, 23.001207486415783

NIK{active}

--

e92

cso30:c:Protein

cso30:i:CC_Cytosol

--

p16

p42

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
194.0, 368.97567820392885
19.94387277829747, 46.024321796071085

IRAK-M

--

e93

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p16

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
663.0, 1382.61937716263
34.463667820069205, 18.380622837370243

IkappaB-alpha

--

e94

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p43

p44

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1060.0, 1268.14
32.48, 24.36

IkappaB-alpha

--

e95

cso30:c:Protein

cso30:i:CC_Cytosol

--

p44

p45

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
828.0, 1332.14
32.48, 24.36

IkappaB-alpha

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p45

p46

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
867.5, 1450.6760873554783
25.315470728574052, 35.32391264452194

IkappaB-alpha:p50:p65

--

e97

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p46

p47

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
586.0, 1473.5640138408305
34.567474048442904, 18.435986159169552

inflammatory mediators

--

e98

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p48

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
77.5, 607.9037491778118
21.233062924797192, 41.09625082218812

TCR ligand:TCR

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
580.0, 468.0
15.0, 15.0

p1

p1

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 e47

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1

m5*m47*0.1

nodelay

--

true

0

false

PMID: 18249132, 17217339 IRAK-4 was shown to phosphorylate NADPH oxidase p47phox and contribute to cellular oxidative response in neutrophils.

Go back
411.0, 911.0
17.0, 17.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e30 e20

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m30*m20*0.1

nodelay

--

true

0

false

PMID: 18249132, 15767370, 15695821 Perhaps one of the major functions of IRAK-1 is to mediate the ligand-stimulated phosphorylation of IRF5/7.

Go back
560.0, 872.0
15.0, 15.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e33 e20

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c34 : 1
stoichiometry:c33 : 1

m33*m20*0.1

nodelay

--

true

0

false

PMID: 18249132, 15767370, 15695821 Perhaps one of the major functions of IRAK-1 is to mediate the ligand-stimulated phosphorylation of IRF5/7.

Go back
494.0, 1174.0
19.0, 19.0

p12

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e42

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9

Go back
601.0, 1153.0
21.0, 21.0

p13

p13

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c37 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18249132 Consequently, interferon alpha4 gene expression is dramatically decreased in IRAK-1¡Ý/¡Ý cells following the stimulation with TLR7 and TLR9 ligand.

Go back
738.0, 298.0
19.0, 19.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e39

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c43 : 1
stoichiometry:c39 : 1

m17*m39*0.1

nodelay

--

true

0

false

PMID: 18249132 Consequently, interferon alpha4 gene expression is dramatically decreased in IRAK-1¡Ý/¡Ý cells following the stimulation with TLR7 and TLR9 ligand.

Go back
695.0, 247.0
17.0, 17.0

p15

p15

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e38

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c40 : 1

m17*m38*0.1

nodelay

--

true

0

false

PMID: 18249132 Consequently, interferon alpha4 gene expression is dramatically decreased in IRAK-1¡Ý/¡Ý cells following the stimulation with TLR7 and TLR9 ligand.

Go back
397.0, 589.0
21.0, 21.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e91 e84 e93

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c129 : 1
stoichiometry:c124 : 1

m91*m84*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2 PMID: 18249132, 17892204 we have observed that IRAK-M primarily affects the alternative NIK-IKK¦Á/IKK¦Á-RelB NF¦ÊB pathway, instead of the classical TAK1-IKK¦Á/IKK¦Â-RelA pathway

Go back
153.0, 1076.0
19.0, 19.0

p17

p17

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e39

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c53 : 1
stoichiometry:c50 : 1

m41*m39*0.1

nodelay

--

true

0

false

PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9.

Go back
223.0, 1051.0
17.0, 17.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e38

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c52 : 1
stoichiometry:c49 : 1

m41*m38*0.1

nodelay

--

true

0

false

PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9.

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258.0, 1038.0
19.0, 19.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c51 : 1
stoichiometry:c48 : 1

m41*m40*0.1

nodelay

--

true

0

false

PMID: 18249132, 15767370 In contrast, NF¦ÊB-mediated gene expressions such as TNF¦Á seem to be un-altered in IRAK-1¡Ý/¡Ý cells upon challenge with agonists for TLR 7/8 as well as TLR9.

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751.0, 71.0
17.0, 17.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 e13

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m14*m13*0.1

nodelay

--

true

0

false

PMID: 18249132 Figure 1

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881.0, 414.0
17.0, 17.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 e43 e45

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c57 : 1
stoichiometry:c56 : 1

m17*m43*m45*0.1

nodelay

--

true

0

false

PMID: 18249132, 16107720 T cell co-stimulatory molecule CD26 can trigger the association of IRAK-1 with caveolin on antigen presenting monocytes, which is responsible for the subsequent expression of co-stimulatory molecule CD86.

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819.0, 1231.0
17.0, 17.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c58 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18249132, 16107720 T cell co-stimulatory molecule CD26 can trigger the association of IRAK-1 with caveolin on antigen presenting monocytes, which is responsible for the subsequent expression of co-stimulatory molecule CD86.

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998.0, 58.0
19.0, 19.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e20

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18249132, 17161373 Upstream kinases such as IRAK-4 may contribute to the initial phosphorylation of IRAK-1 at Threonine 381

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1114.0, 42.0
19.0, 19.0

p23

p23

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e48

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18249132 Following such event, IRAK-1 can be quickly activated and exhibit self-phosphorylation within its Pro/Ser rich region

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1258.0, 218.0
19.0, 19.0

p24

p24

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 18249132 This self-phosphorylation may subject the IRAK-1 molecule to subsequent ubiquitination and proteosome-mediated degradation.

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1274.0, 286.0
19.0, 19.0

p25

p25

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e64

e24 e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18249132 This self-phosphorylation may subject the IRAK-1 molecule to subsequent ubiquitination and proteosome-mediated degradation.

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245.0, 56.0
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e66 e67

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c71 : 1

m66*m67*0.1

nodelay

--

true

0

false

PMID: 18249132, 16690127, 15465816 IRAK-1 also gets sumoylated following either LPS or Pam3CSK4 challenge.

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258.0, 238.0
19.0, 19.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 e15 e17 e47

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m65*m15*m17*m47*0.1

nodelay

--

true

0

false

PMID: 18249132, 16690127, 15465816 IRAK-1 also gets sumoylated following either LPS or Pam3CSK4 challenge. PMID: 18249132, 11960013 MyD88 is critically involved in recruiting IRAK-4 into the TLR4 complex

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162.0, 290.0
19.0, 19.0

p28

p28

cso30:i:ME_Sumoylation

cso30:i:CC_Cytosol

--

e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 18249132, 16690127, 15465816 IRAK-1 also gets sumoylated following either LPS or Pam3CSK4 challenge.

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204.0, 504.0
23.0, 23.0

p29

p29

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e69

e70 e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 18249132, 15465816 Sumoylated IRAK-1 enters the nucleus and contributes to Stat3 activation and selected gene expression

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827.0, 42.5
18.5, 18.5

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m12*m15*0.1

nodelay

--

true

0

false

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407.0, 1295.0
17.0, 17.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e72 e70

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c85 : 1
stoichiometry:c84 : 1

m72*m70*0.1

nodelay

--

true

0

false

PMID: 18249132, 15465816 Sumoylated IRAK-1 enters the nucleus and contributes to Stat3 activation and selected gene expression

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472.0, 1356.0
15.0, 15.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e73

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m73*0.1

nodelay

--

true

0

false

PMID: 18249132, 15465816 Sumoylated IRAK-1 enters the nucleus and contributes to Stat3 activation and selected gene expression

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997.0, 1682.0
17.0, 17.0

p32

p32

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76 e75 e78

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c89 : 1

m76*m75*0.1

nodelay

--

true

0

false

PMID: 18249132 Overexpression of IRAK-1c blocks IL-1¦Â induced MAP kinase activation, suggesting that IRAK-1c may serve as a negative regulator of inflammation.

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490.0, 290.0
19.0, 19.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e15 e79 e80 e47

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c116 : 1
stoichiometry:c96 : 1

m12*m15*m79*m80*m47*0.1

nodelay

--

true

0

false

PMID: 18249132 Upon overexpression, IRAK-2 can associate with MyD88 as well as TRAF6, and activate NF¦ÊB-dependent reporter gene expression.

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315.0, 1051.0
17.0, 17.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e84

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c99 : 1
stoichiometry:c98 : 1

m41*m84*0.1

nodelay

--

true

0

false

PMID: 18249132 Upon overexpression, IRAK-2 can associate with MyD88 as well as TRAF6, and activate NF¦ÊB-dependent reporter gene expression. PMID: 18249132, 17878161 A recent study further confirmed that indeed IRAK-2 instead of IRAK-1 is primarily involved in TRAF-6 ubiquitination and NF¦ÊB activation

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546.0, 1138.0
19.0, 19.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e42

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18249132 Upon overexpression, IRAK-2 can associate with MyD88 as well as TRAF6, and activate NF¦ÊB-dependent reporter gene expression.

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717.0, 421.0
21.0, 21.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e79 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m12*m79*m82*0.1

nodelay

--

true

0

false

PMID: 18249132, 11544529 IRAK-2, instead of IRAK-1 can also interact with another distinct TLR intracellular adaptor molecule Mal/TIRAP

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343.0, 71.0
17.0, 17.0

p37

p37

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e81

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m81*0.1

nodelay

--

true

0

false

PMID: 18249132, 17878161 A recent study further confirmed that indeed IRAK-2 instead of IRAK-1 is primarily involved in TRAF-6 ubiquitination and NF¦ÊB activation

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246.0, 874.0
19.0, 19.0

p38

p38

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e85

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c113 : 1
stoichiometry:c111 : 1

m41*m85*0.1

nodelay

--

true

0

false

PMID: 18249132 Upon overexpression, IRAK-2a and IRAK-2b can activate, while IRAK-2c and IRAK-2d inhibit NF¦ÊB activation.

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196.0, 1072.0
15.0, 15.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e86 e87 e88

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c109 : 1

m41*m86*0.1

nodelay

--

true

0

false

PMID: 18249132 Upon overexpression, IRAK-2a and IRAK-2b can activate, while IRAK-2c and IRAK-2d inhibit NF¦ÊB activation.

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920.0, 216.0
15.0, 15.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 e18 e19 e17 e47

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c60 : 1
stoichiometry:c11 : 1

m16*m18*m19*m17*m47*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.1

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214.0, 710.0
19.0, 19.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 e84

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m11*m84*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
542.0, 638.0
19.0, 19.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e90 e89

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m90*m89*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
542.0, 598.0
19.0, 19.0

p42

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e90 e92

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c128 : 1
stoichiometry:c127 : 1

m90*m92*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
680.0, 1276.0
23.0, 23.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
943.0, 1223.0
17.0, 17.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e94

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c132 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
990.0, 1334.0
19.0, 19.0

p45

p45

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e95

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m95*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
766.0, 1430.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e29 e96

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m29*m96*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
1061.0, 1048.0
19.0, 19.0

p47

p47

cso30:i:ME_NuclearExport

cso30:i:CC_Cytosol

--

e97

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
611.0, 1295.0
17.0, 17.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e29

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c141 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18249132 From fig.2

Go back
158.0, 626.0
19.0, 19.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e99 e47 e101

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c146 : 1
stoichiometry:c145 : 1

m99*m47*m101*0.1

nodelay

--

true

0

false

PMID: 18249132 Upon TCR stimulation, IRAK-4 is recruited to T cell lipid rafts, where it can associate with Zap70 and activate protein kinase C.

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759.0, 635.0
17.0, 17.0

p5

p5

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e21 e23

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c17 : 1
stoichiometry:c16 : 1

m21*m23*0.1

nodelay

--

true

0

false

PMID: 18249132 The first step involves the classical pathway causing the activation of IKK¦Á/¦Â complex, which contributes to I¦ÊB¦Á phosphorylation and degradation, and subsequent nuclear translocation of p65/RelA.

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168.0, 852.0
15.0, 15.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e103 e100

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c149 : 1
stoichiometry:c148 : 1

m103*m100*0.1

nodelay

--

true

0

false

PMID: 18249132 Upon TCR stimulation, IRAK-4 is recruited to T cell lipid rafts, where it can associate with Zap70 and activate protein kinase C.

Go back
411.0, 1079.0
17.0, 17.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e41 e100

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c152 : 1
stoichiometry:c151 : 1

m41*m100*0.1

nodelay

--

true

0

false

PMID: 18249132, 16574867 IRAK-4 is also critically involved in T cell receptor (TCR)-induced T cell proliferation through NF¦ÊB activation

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0.0, 1056.0
23.0, 23.0

p52

p52

cso30:i:CE_CellProliferation

cso30:i:CC_Cytosol

--

e42

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18249132, 16574867 IRAK-4 is also critically involved in T cell receptor (TCR)-induced T cell proliferation through NF¦ÊB activation

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757.0, 809.0
21.0, 21.0

p6

p6

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e22

e24 e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m22*0.1

nodelay

--

true

0

false

Go back
814.0, 954.0
19.0, 19.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e25 e27

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c23 : 1
stoichiometry:c22 : 1

m25*m27*0.1

nodelay

--

true

0

false

PMID: 18249132 The second step involves IKK¦Å/TBK-1 dependent p65/RelA phosphorylation, which is independent of the classical pathway and I¦ÊB¦Á degradation.

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879.0, 767.0
17.0, 17.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e28 e20

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1
stoichiometry:c26 : 1
stoichiometry:c25 : 1

m28*m20*0.1

nodelay

--

true

0

false

PMID: 18249132 Figure 1 PMID: 18249132 Recent evidence indicates that IRAK-1 contributes to NF¦ÊB activation by facilitating p65/RelA phosphorylation, but not the classical pathway leading to I¦ÊB¦Á degradation and p65 nuclear translocation

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830.0, 1102.0
19.0, 19.0

p9

p9

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e26

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 18249132 The first step involves the classical pathway causing the activation of IKK¦Á/¦Â complex, which contributes to I¦ÊB¦Á phosphorylation and degradation, and subsequent nuclear translocation of p65/RelA.

Go back
492.0, 476.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 172.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.0, 1149.8512285683985

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.0, 1157.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0444804244769, 178.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.0, 369.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 227.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
99.0, 432.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.9322862329902, 92.367306591753

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.0, 88.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.87386041495083, 981.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
208.0, 1087.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 172.49227473161196

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.0, 900.2228841505914

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.0, 893.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
183.0, 1094.909724033798

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
194.0, 900.9552043140169

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
205.68176793138858, 1090.9414708533402

c114

c114

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
161.0, 1090.5686286326209

c115

c115

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
515.5351642186213, 310.61428527896265

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
176.0, 720.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 729.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
227.7754848024334, 174.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.0, 239.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 648.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.0, 648.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
240.0, 655.1425318636377

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
412.69943715464836, 543.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
393.5777087639997, 610.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.0, 174.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
492.0, 616.8011913178791

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
561.0, 611.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
402.0, 611.8879786248059

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
214.0, 402.0

c129

c129

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
866.0, 224.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.1927794053147, 1211.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.9457031182809, 1299.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 1235.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 1241.0707738225208

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1015.1651621784848, 1293.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 1344.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.0, 1211.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.6414582374399, 1357.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
785.0, 1442.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.0, 1074.2509116618855

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.0, 233.34993041882234

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.3392856243815, 735.9575186966783

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.7375856844859, 1312.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.1267774132938, 1208.0

c142

c142

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
99.0, 629.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
184.91461313311873, 540.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.53844189001197, 645.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.0, 579.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
159.0, 821.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
161.89957008923957, 867.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
100.0, 767.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.0, 589.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.0, 979.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.98354785709813, 1093.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
100.0, 764.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
30.267664513673562, 1076.3438080861033

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.0, 652.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
684.0, 644.319744306791

c17

c17

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
768.0, 733.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.9855012812532, 830.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 483.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.1313708498985, 830.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
761.0, 964.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.0, 973.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.0, 836.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
868.0, 724.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
844.4562426052674, 783.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.1757405895299, 168.0

c26

c26

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
827.0, 1052.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
767.8684916881048, 1121.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 843.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.7671406211725, 479.9161227964126

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.08956037820286, 928.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
431.71207880495865, 166.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
568.0, 787.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 887.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.9371099599649, 168.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
275.0, 1180.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.24, 1193.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 1174.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
764.6484336655659, 282.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 308.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.0, 31.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0640869902634, 264.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
719.8688524590164, 258.44262295081967

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 63.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.0, 78.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.3000309052043, 327.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
170.29885918939317, 981.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 981.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 981.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.7178136391697, 1057.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
234.0, 1068.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 94.67571687801386

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
172.0, 1095.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.8309544081523, 68.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
237.25312389378374, 63.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
167.95125802933273, 78.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
847.0, 299.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
905.2133326521492, 372.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.0, 429.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.9995660075404, 420.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
803.6568542494924, 1248.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.3722446130168, 545.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
760.0, 88.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 238.6872556354166

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
985.0, 84.5765270353264

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.0, 77.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.0, 68.46162468034939

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.0, 61.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1174.0, 169.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1207.0, 228.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1199.0, 236.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.6568542494924, 305.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1211.0, 296.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.0, 67.5655472379027

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
220.0, 82.3147951171725

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 75.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
167.0, 41.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.6374626626937, 175.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.99112939549843, 225.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.98754961864444, 249.4461514201405

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.13170818847027, 256.62473975817664

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
102.0, 248.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
94.0, 254.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
95.48229005965027, 304.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.0, 68.61414093177913

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
88.0, 351.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
219.0, 527.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
99.0, 516.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.0, 1304.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 1305.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.0, 1261.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.0, 1325.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
487.0, 1364.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.0, 1698.0214708392368

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 1657.9221668432237

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
839.0, 61.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.0, 1706.6181224662466

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1008.7155417527999, 1462.0

c91

c91

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
516.0242644708486, 162.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.7167176489606, 228.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.0, 305.3056055099479

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.0, 300.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
442.3373412826452, 175.27063636576278

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
231.0, 981.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
266.9088269514547, 1068.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
324.24617754568743, 174.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back