PMID: 18251777 Macrophages incubated in medium containing lipo-MDP increased DNA fragmentation.

PMID: 18251777 After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.

PMID: 18251777 After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.

PMID: 18251777 GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.

PMID: 18251777 GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.

PMID: 18251777 Complement receptor type 3 (CR3) and the receptor of internalin A (InlA) mediate the uptake of Listeria.

PMID: 18251777, 7867067 A class A type III macrophage receptor with a collagenous structure (MARCO) is a trimeric membrane glycoprotein mediating the uptake of chemically modified low-density lipoproteins.

PMID: 18251777 Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense. PMID: 18251777 LPS is known to bind to several receptors on macrophages, including CD14 and MSR-A, and stimulates macrophages to release various nflammatory mediators.

PMID: 18251777 LPS is known to bind to several receptors on macrophages, including CD14 and MSR-A, and stimulates macrophages to release various nflammatory mediators.

PMID: 18251777 Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense.

PMID: 18251777 Type I and type II MSR-A recognize a variety of polyanions such as chemically modified lipoproteins, LPS of Gramnegative bacteria, and lipoteichoic acid of Gram-positive bacteria, suggesting a role in host defense.

PMID: 18251777 These results imply that the intralysosomal accumulation of MDP generates signals to induce macrophage apoptosis.

PMID: 18251777 LPS-induced expression of cytokines in the liver was similar in MSR-A+/+and MSR-A-/? mice, but levels of IL-1beta expression and serum IL-1beta were lower in MSR-A-/? mice.

PMID: 18251777 LPS-induced expression of cytokines in the liver was similar in MSR-A+/+and MSR-A-/? mice, but levels of IL-1beta expression and serum IL-1beta were lower in MSR-A-/? mice.

PMID: 18251777 Expression of scavenger receptors is enhanced by macrophage colony-stimulating factor (M-CSF) and granulocyte?macrophage colony-stimulating factor (GM-CSF).

PMID: 18251777 Expression of scavenger receptors is enhanced by macrophage colony-stimulating factor (M-CSF) and granulocyte?macrophage colony-stimulating factor (GM-CSF).

PMID: 18251777 Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.

PMID: 18251777 Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.

PMID: 18251777 Scavenger receptors uptake oxidized low-density lipoprotein (oxLDL) and intracellular accumulation of cholesterol stimulate LXRalpha.

PMID: 18251777, 14527307 This modified enzyme is endocytosed after it binds to cell-surface mannose receptors and is subsequently delivered to lysosomes where it supplements the defective enzyme.

PMID: 18251777 Liver X receptors (LXR) are also involved in cholesterol metabolism in macrophages.

PMID: 18251777, 7935418, 7744246 LXR are nuclear receptors initially identified in the liver that form a functional heterodimer with the retinoid X receptor (RXR) to recognize and bind to its hormone response elements.

PMID: 18251777 Heme oxygenase 1 (HO-1) in macrophages and hepatocytes plays a key role in bilirubin metabolism. Senescent or denatured erythrocytes incorporated by Kupffer cells and non-heme protein in hepatocytes are a major source of bilirubin.

PMID: 18251777, 7935418, 7744246 LXR are nuclear receptors initially identified in the liver that form a functional heterodimer with the retinoid X receptor (RXR) to recognize and bind to its hormone response elements.

PMID: 18251777, 9794827, 12449021, 12193651 LXR are activated by a number of oxidized derivatives of cholesterol (oxysterols) and promote the synthesis of ABCA1 and other transporters, which reduce intracellular levels of cholesterol and thus protect against atherosclerosis.

PMID: 18251777, 9794827, 12449021, 12193651 LXR are activated by a number of oxidized derivatives of cholesterol (oxysterols) and promote the synthesis of ABCA1 and other transporters, which reduce intracellular levels of cholesterol and thus protect against atherosclerosis. PMID: 18251777 A potent TLR3 agonist, poly I:C, and a TLR4 agonist, lipid A, selectively inhibit the synthesis of ABCA1 and other cholesterol efflux mediators, when macrophages are stimulated with synthetic LXR agonists.

PMID: 18251777 We also confirmed that LXRa expression was markedly decreased in the rat liver after zymosan injection and we therefore cultured human monocytes in the presence of LPS or zymosan.

PMID: 18251777, 12524534 LXR agonist inhibits LPS-TLR4 activation of nuclear factor-kappaB target genes, including inflammatory cytokines.

PMID: 18251777, 12524534 LXR agonist inhibits LPS-TLR4 activation of nuclear factor-kappaB target genes, including inflammatory cytokines.

PMID: 18251777 LXRalpha upregulates several target genes that remove cholesterol from macrophages.

PMID: 18251777 Complement receptor type 3 (CR3) and the receptor of internalin A (InlA) mediate the uptake of Listeria.

PMID: 18251777 The effects of M-CSF are mediated by the M-CSF receptor (M-CSFR), encoded by the c-fms proto-oncogene.

PMID: 18251777, 8426088 These results indicate that the differentiation and maturation of tissue macrophages are mediated by M-CSF, but dendritic cell differentiation is controlled by other factor(s) than M-CSF, most probably by GM-CSF.

PMID: 18251777, 8426088 These results indicate that the differentiation and maturation of tissue macrophages are mediated by M-CSF, but dendritic cell differentiation is controlled by other factor(s) than M-CSF, most probably by GM-CSF. PMID: 18251777 GM-CSF is also a hematopoietic growth factor that stimulates the survival, proliferation, differentiation, and function of myeloid cells and their precursors, particularly neutrophils and monocyte/macrophages.

PMID: 18251777 GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression.

PMID: 18251777 GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression. PMID: 18251777 Thus, GM-CSF acts as a stimulator of terminal differentiation of alveolar macrophages, principally through PU.1 expression.

PMID: 18251777 After LPS administration cytokine production and the expression of LPS receptors, such as CD14 and macrophage scavenger receptor class A (MSR-A), were induced at lower levels in op/op mice than in littermate mice, indicating that deficient macrophage activation following LPS injection in op/op mice is associated with the decreased expression of CD14 and MSR-A in the liver.