1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18262679.csml convertedTime:2009.07.01.11:15

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title TLR3: interferon induction by double-stranded RNA including poly(I:C).
Authors Matsumoto M, Seya T.
Affiliation Department of Microbiology and Immunology, Hokkaido University Graduate Schoolof Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.matumoto@pop.med.hokudai.ac.jp
Abstract Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and itssynthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and inducestype I interferon (IFN), inflammatory cytokine/chemokine production anddendritic cell (DC) maturation via the adaptor protein TICAM-1 (also calledTRIF). TLR3 is expressed both intracellularly and on the cell surface offibroblasts and epithelial cells, but is localized to the endosomal compartmentof myeloid DCs. Several studies in TLR3-deficient mice demonstrate that TLR3participates in the generation of protective immunity against some viralinfections. Involvement of TLR3-TICAM-1 in activation of NK cells and CTLs bymyeloid DCs suggests that TLR3 serves as an inducer of cellular immunity sensingviral infection rather than a simple IFN inducer. In this review, we summarizethe current knowledge on TLR3 and discuss its possible role in innate andadaptive immunity.
PMID 18262679
Model Abstract

Entity

G010228:IFN-beta MO000000030:PI3K MO000000048:AKT MO000000058:NF-kappaB MO000000065:RIP1 MO000000085:Src MO000000212:TRAF6 MO000000276:AP-1{active} MO000007694:IRF-3 MO000016608:IKK-i MO000016660:IFNbeta MO000016963:TRAF3 MO000018132:CD14 MO000019331:TBK1 MO000019398:TLR3 MO000022224:dsRNA,Poly (I:C) MO000041125:TRIF MO000041437:dsRNA:TLR3(2):TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000066987:DDX58 MO000103999:IFIH1 e1: e10: e11: e12:dsRNA:CD14 e13:dsRNA:CD14 e14:dsRNA:TLR3(2) e15:dsRNA e16:dsRNA:TLR3(2){p} e17:TRIF:RIP1 e18:Nap1 e19:TRIF:TRAF3:Nap1 e2: e20:TRIF:TRAF6 e21:NF-kappaB{active} e22:TRIF:TRAF3:Nap1:TBK1:IKK-i e23:IRF-3{p} e24:SARM e25:TRIF:SARM e26:NF-kappaB{active} e27:dsRNA:TLR3(2){p}:PI3K e28:dsRNA:TLR3(2){p}:PI3K:Src e29:AKT{p} e3: e30:Src kinase inhibitor e31:AP-1 e32:AP-1{active} e33:Cytokine/Chemokine e34:Cytokine/Chemokine e35:ssRNA e36:Poly(I:C) e37:DDX58:dsRNA e38:DDX58:ssRNA e39:IFIH1:Poly(I:C) e4: e40:IFN-alpha e41:IFNalpha e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p5 p6 p7 p8 p9
Model Detail
690.0, 1222.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19

p33 p35 p37

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
1005.0, 585.0
22.0, 22.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m29

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
897.0, 857.0
22.0, 22.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
289.0, 869.0
22.0, 22.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p12

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
315.0, 555.0
18.0, 18.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
907.0, 779.0
18.0, 18.0

Src

--

MO000000085

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000085

--

Go back
714.0, 762.0
20.0, 20.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
566.0, 1034.0
20.0, 20.0

AP-1{active}

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p19

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
764.0, 776.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p22

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
397.0, 781.0
22.0, 22.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
86.0, 1166.0
20.0, 20.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32 p35 p37

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
483.0, 503.0
18.0, 18.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
712.0, 132.0
24.0, 24.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p1

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
401.0, 721.0
22.0, 22.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
721.0, 313.0
22.0, 22.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
663.0, 71.0
26.0, 26.0

dsRNA,Poly (I:C)

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
618.0, 602.0
20.0, 20.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p5 p8 p9 p10 p17

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
759.0, 655.0
26.0, 26.0

dsRNA:TLR3(2):TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p6 p24

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
729.0, 381.0
22.0, 22.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3

p4

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
813.0, 869.0
22.0, 22.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15 p22

p16 p40

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
298.0, 242.0
20.0, 20.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
534.0, 342.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
164.1877088443035, 109.5235254541347
983.9550164338423, 1428.7026838619383

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
178.66804691710698, 137.36058442409228
953.7537240064179, 1341.6633088463152

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
704.6984241366887, 288.0
277.86042895340637, 463.8856313883143

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
818.5, 136.0
19.89068488585236, 24.355940676553907

dsRNA:CD14

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
850.5, 304.0
19.89068488585236, 24.355940676553907

dsRNA:CD14

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
730.5, 492.0
18.829195134144307, 23.05615730711548

dsRNA:TLR3(2)

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p7

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
419.0, 239.0
26.0, 26.0

dsRNA

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
726.5, 548.0
18.829195134144307, 23.05615730711548

dsRNA:TLR3(2){p}

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6 p7

p5 p20

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
344.5, 674.0
22.09531744709214, 27.05549075154141

TRIF:RIP1

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p12 p13

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
396.5, 515.0
15.711410746629104, 25.477963372912054

Nap1

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
457.5, 668.0
28.377316938887873, 39.596256193797025

TRIF:TRAF3:Nap1

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p14

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
164.1877088443035, 109.5235254541347
983.9550164338423, 1428.7026838619383

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
576.5, 786.0
22.82202966172305, 27.94534244292619

TRIF:TRAF6

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p11

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
365.0, 937.0
22.0, 22.0

NF-kappaB{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p12

p18 p38

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
518.0, 832.0
19.764705882352942, 32.94117647058823

TRIF:TRAF3:Nap1:TBK1:IKK-i

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
701.0, 1005.0
22.0, 22.0

IRF-3{p}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p19

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
548.0, 435.5
23.35999999999999, 17.51999999999999

SARM

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
548.5, 654.0
22.511748041993, 27.565405765705716

TRIF:SARM

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p12 p15

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
513.0, 1077.0
21.0, 21.0

NF-kappaB{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p19

true true true true

csml-variable:Double

m28

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
932.5, 624.0
23.22426133235456, 32.4059460451459

dsRNA:TLR3(2){p}:PI3K

--

e27

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p20

p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
871.0, 705.0
18.176470588235297, 30.294117647058826

dsRNA:TLR3(2){p}:PI3K:Src

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22 p23

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1001.0, 909.0
22.0, 22.0

AKT{p}

--

e29

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
183.8668091729803, 129.20262578281157
944.5968157764885, 1389.3444832045857

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
922.0, 907.0
11.662301216089803, 26.913002806361092

Src kinase inhibitor

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p23

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
546.0, 726.0
20.0, 20.0

AP-1

--

e31

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
686.0, 894.0
20.0, 20.0

AP-1{active}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24

p25 p39

true true true true

csml-variable:Double

m35

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
734.0, 1156.0
43.75432525951557, 23.335640138408305

Cytokine/Chemokine

--

e33

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p38 p39 p40

p26 p27 p28

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1181.0, 1103.5
21.92, 16.439999999999998

Cytokine/Chemokine

--

e34

cso30:c:Protein

cso30:i:CC_Extracellular

--

p26 p27 p28

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
458.0, 284.5
60.0, 31.0

ssRNA

--

e35

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
576.0, 234.0
48.89823380992431, 27.708999158957106

Poly(I:C)

--

e36

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
312.5, 386.0
22.470921513081155, 27.515414097650396

DDX58:dsRNA

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p32 p33

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
432.5, 418.0
22.470921513081155, 27.515414097650396

DDX58:ssRNA

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p36 p37

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
596.5, 394.0
22.470921513081155, 27.515414097650396

IFIH1:Poly(I:C)

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p34 p35

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
220.27314478103264, 163.64105135799582
871.7841445603844, 1320.4676320542158

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
505.0, 1184.0
45.77854671280277, 24.41522491349481

IFN-alpha

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p32 p34 p36

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
104.0, 1030.0
15.626753975678204, 36.06173994387278

IFNalpha

--

e41

cso30:c:Protein

cso30:i:CC_Extracellular

--

p33 p34 p36

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
704.6984241366887, 288.0
277.86042895340637, 463.8856313883143

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
431.46786347407743, 949.4546419776497
473.0439309020946, 428.9988721588833

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
482.5601316162029, 959.621291581553
276.60296890737004, 415.7853545359195

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
437.6341716981271, 955.1804996142671
460.7113144539955, 417.54715688564795

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
438.5150728729913, 956.0614007891311
458.9495121042668, 415.7853545359195

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
431.46786347407743, 949.4546419776497
473.0439309020946, 428.9988721588833

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
431.46786347407743, 949.4546419776497
473.0439309020946, 428.9988721588833

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
438.5150728729913, 956.0614007891311
458.9495121042668, 415.7853545359195

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
776.7811240208579, 1125.6348769504966
29.553185660957414, 26.753410177287794

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
699.2618206328057, 1248.96104143149
83.6856116121024, 75.75750103832438

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
431.46786347407743, 949.4546419776497
473.0439309020946, 428.9988721588833

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
704.6984241366887, 288.0
277.86042895340637, 463.8856313883143

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
542.9616563527063, 1140.0981959181931
14.980606226625204, 7.212884479486217

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
542.461411506971, 1118.5876675515826
51.27509668785222, 92.295174038134

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
563.9719398735826, 1178.6170490398001
8.003917531762289, 8.003917531762294

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
178.1154425799446, 102.27273799751666
964.9533212443058, 1367.3139312096434

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
181.5628382427823, 126.40450763738008
925.6912192318563, 1344.1036503246562

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
190.75589334368263, 150.53627727724353
921.4649310425915, 1326.476067752548

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
762.0, 74.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000018132

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m119368*m2828*0.1

nodelay

--

true

0

false

PMID: 18262679,16473828 A recent study demonstrated that CD14 enhances dsRNA-mediated TLR3 activation by directly binding to poly(I:C) and mediating cellular uptake of poly(I:C)

Go back
617.0, 677.0
21.0, 21.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000000212

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m18998*m183*0.1

nodelay

--

true

0

false

PMID: 18262679 TRAF6 directly binds to the N-terminal region of TICAM-1 through the TRAF domain PMID: 18262679,14982987 Although TRAF6 is required for NF-¦ÊB activation in MEFs,poly(I:C)-induced NF-¦ÊB activation is not impaired in TRAF6-deficient macrophages

Go back
542.0, 906.0
19.0, 19.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e20 MO000000058

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m21*m22*0.1

nodelay

--

true

0

false

PMID: 18262679,14982987 Although TRAF6 is required for NF-¦ÊB activation in MEFs,poly(I:C)-induced NF-¦ÊB activation is not impaired in TRAF6-deficient macrophages

Go back
334.0, 762.0
19.0, 19.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 MO000000058 e25

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c49 : 1
stoichiometry:c35 : 1

m18*m22*0.1

nodelay

--

true

0

false

PMID: 18262679 RIP1 associates with TICAM-1 via the PHIM domain in the C-terminal region and acts as an NF-¦ÊB activator and apoptosis mediator in TICAM-1-mediated signaling. PMID: 18262679,15814722,15064760,14739303 Receptor-interacting protein 1 (RIP1), a kinase containing a death domain, associates with TICAM-1 via the RIP homotypic interaction motif (RHIM) domain in the C-terminal region and acts as an NF-¦ÊB inducer and apoptosis mediator in TICAM-1-mediated signaling PMID: 18262679 SARM and TICAM-1 have been shown to interact and SARM strongly suppresses NF-¦ÊB activation as well as IRF-3 activation by TICAM-1.

Go back
116.0, 760.0
23.0, 23.0

p13

p13

cso30:i:CE_Apoptosis_InhibitionOfCellSurvival_

cso30:i:CC_Cytosol

--

e17

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18262679 RIP1 associates with TICAM-1 via the PHIM domain in the C-terminal region and acts as an NF-¦ÊB activator and apoptosis mediator in TICAM-1-mediated signaling. PMID: 18262679,15814722,15064760,14739303 Receptor-interacting protein 1 (RIP1), a kinase containing a death domain, associates with TICAM-1 via the RIP homotypic interaction motif (RHIM) domain in the C-terminal region and acts as an NF-¦ÊB inducer and apoptosis mediator in TICAM-1-mediated signaling

Go back
482.0, 754.0
19.0, 19.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000019331 MO000016608

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m20*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 18262679 TRAF3 and NAP1 participate in the recruitment and activation of the IRF-3 kinases TBK1 and IKKvar epsilon. PMID: 18262679,12702806,12692549 Once TICAM-1 is oligomerized, the serine-threonine kinases, TANK-binding kinase 1 (TBK-1; also called NAK or T2K) and I¦ÊB kinase-related kinase var epsilon (IKK-var epsilon; also called IKK-i), are activated and phosphorylate IRF-3

Go back
710.0, 838.0
19.0, 19.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22 MO000007694 e25

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1
stoichiometry:c50 : 1
stoichiometry:c43 : 1

m24*m977*0.1

nodelay

--

true

0

false

PMID: 18262679, 12702806, 12692549 Once TICAM-1 is oligomerized, the serine-threonine kinases, TANK-binding kinase 1 (TBK-1; also called NAK or T2K) and I¦ÊB kinase-related kinase var epsilon (IKK-var epsilon; also called IKK-i), are activated and phosphorylate IRF-3 PMID: 18262679 SARM and TICAM-1 have been shown to interact and SARM strongly suppresses NF-¦ÊB activation as well as IRF-3 activation by TICAM-1.

Go back
766.0, 922.0
19.0, 19.0

p16

p16

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041456

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18262679,11070172 Phosphoprylated IRF-3 translocates into the nucleus and induces IFN-beta gene transcription PMID: 18262679 Phosphorylated IRF-3 translocates into the nucleus and together with NF-KappaB and AP-1 induces IFN-beta gene transcription.

Go back
550.0, 514.0
19.0, 19.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000041125

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m26*m18998*0.1

nodelay

--

true

0

false

PMID: 18262679 SARM and TICAM-1 have been shown to interact and SARM strongly suppresses NF-¦ÊB activation as well as IRF-3 activation by TICAM-1.

Go back
434.0, 1006.0
19.0, 19.0

p18

p18

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e21

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18262679 Phosphorylated IRF-3 translocates into the nucleus and together with NF-¦ÊB and AP-1 induces IFN-beta gene transcription

Go back
624.0, 1112.0
22.0, 22.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e26 e23 MO000000276

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c92 : 1

m28*m25*m219*0.1

nodelay

--

true

0

false

PMID: 18262679 Phosphorylated IRF-3 translocates into the nucleus and together with NF-kappaB and AP-1 induces IFN-beta gene transcription

Go back
818.0, 214.0
19.0, 19.0

p2

p2

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18262679, 16473828 A recent study demonstrated that CD14 enhances dsRNA-mediated TLR3 activation by directly binding to poly (I: C) and mediating cellular uptake of poly (I: C) PMID: 182626279 The internalized poly(I:C) colocalizes with CD14 and TLR3.

Go back
798.0, 550.0
19.0, 19.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000000030

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m16*m29*0.1

nodelay

--

true

0

false

PMID: 18262679 Phosphatidylinositol 3-kinase (PI3-K) is recruited to these residues, and is required for full phosphorylation and activation of IRF-3.

Go back
970.0, 694.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000000085

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m30*m77*0.1

nodelay

--

true

0

false

PMID: 18262679,16858407 TLR3 also associates with c-Src tyrosine kinase on the endosome in response to dsRNA

Go back
838.0, 814.0
19.0, 19.0

p22

p22

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e28 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m31*m977*0.1

nodelay

--

true

0

false

Phosphatidylinositol 3-kinase (PI3-K) is recruited to these residues, and is required for full phosphorylation and activation of IRF-3.

Go back
1001.0, 741.0
19.0, 19.0

p23

p23

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000048 e28 e30

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c65 : 1
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m45*m31*0.1

nodelay

--

true

0

false

PMID: 18262679 The Src kinase inhibitor markedly inhibits dsRNA-elicited phosphorylation of Akt, a downstream target of PI3-K.

Go back
634.0, 782.0
19.0, 19.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041437 e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m19305*m34*0.1

nodelay

--

true

0

false

PMID: 18262679,12855817 This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation

Go back
625.0, 909.0
21.0, 21.0

p25

p25

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e32

MO000000276

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18262679 Phosphorylated IRF-3 translocates into the nucleus and together with NF-kappaB and AP-1 induces IFN-beta gene transcription

Go back
946.0, 1106.0
19.0, 19.0

p26

p26

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 18262679, 12855817 This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation

Go back
938.0, 1062.0
19.0, 19.0

p26

p27

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 18262679, 12855817 This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation

Go back
970.0, 1010.0
19.0, 19.0

p26

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 18262679, 12855817 This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation

Go back
282.0, 314.0
19.0, 19.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e15

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m41844*m15*0.1

nodelay

--

true

0

false

PMID: 18262679,17038590,17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
766.0, 262.0
19.0, 19.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 e13

MO000041446 MO000018132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3965*m13*0.1

nodelay

--

true

0

false

PMID: 18262679,15644310 Since the extracellular domain of CD14 consists of LRRs,poly(I:C) might be transferred from CD14 to TLR3. PMID: 182626279,11607032,16225392 TLR3 recognizes both in vitro-transcribed dsRNA and poly(I:C), suggesting that the RNA duplex and not 5¡ì-triphosphate is critical for TLR3 activation

Go back
398.0, 338.0
19.0, 19.0

p29

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e35

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m41844*m38*0.1

nodelay

--

true

0

false

PMID: 18262679,17038590,17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
602.0, 306.0
19.0, 19.0

p29

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e36

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m76904*m39*0.1

nodelay

--

true

0

false

PMID: 18262679,17038590,17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
329.0, 1193.0
21.0, 21.0

p32

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e37

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m43*m40*0.1

nodelay

--

true

0

false

PMID: 18262679, 17038590, 17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
289.0, 1105.0
21.0, 21.0

p32

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e37

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m93217*m40*0.1

nodelay

--

true

0

false

PMID: 18262679, 17038590, 17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
365.0, 1085.0
21.0, 21.0

p32

p34

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e39

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m43*m42*0.1

nodelay

--

true

0

false

PMID: 18262679, 17038590, 17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
397.0, 1241.0
21.0, 21.0

p32

p35

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e39

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m93217*m42*0.1

nodelay

--

true

0

false

PMID: 18262679, 17038590, 17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
345.0, 1001.0
21.0, 21.0

p32

p36

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e40 e38

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m43*m41*0.1

nodelay

--

true

0

false

PMID: 18262679, 17038590, 17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
357.0, 1297.0
21.0, 21.0

p32

p37

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e38

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m93217*m41*0.1

nodelay

--

true

0

false

PMID: 18262679, 17038590, 17038589 RIG-I and MDA5 recognize 5¡ì-triphosphate-containing ssRNA/dsRNA and poly(I:C), respectively and induce IFN-alpha/beta production

Go back
714.0, 1086.0
22.0, 22.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e21

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c111 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18262679, 12855817 This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation

Go back
753.0, 1057.0
22.0, 22.0

p38

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c113 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18262679, 12855817 This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation

Go back
731.0, 443.0
17.0, 17.0

p4

p4

cso30:i:ME_Dimerization

cso30:i:CC_EndosomeLumen

--

MO000041446

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m19314*0.1

nodelay

--

true

0

false

PMID: 182626279 Once TLR3 is dimerized by internalized dsRNA, it recruits the adaptor protein TICAM-1/TRIF

Go back
801.0, 1053.0
22.0, 22.0

p38

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c114 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18262679, 12855817 This activates the transcription factors interferon regulatory factor 3 (IRF-3), NF-KappaB, and AP-1 (a complex of activating transcription factor 2 (ATF2) and JUN), leading to the induction of type I IFN (especially IFN-beta), cytokine/chemokine production and dendritic cell (DC) maturation

Go back
606.0, 550.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 e16

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c17 : 1
stoichiometry:c15 : 1

m18998*m16*0.1

nodelay

--

true

0

false

PMID: 182626279 Once TLR3 is dimerized by internalized dsRNA, it recruits the adaptor protein TICAM-1/TRIF PMID: 18262679,12855817 TLR3 mediates signals via the adaptor protein TICAM-1/TRIF

Go back
750.0, 602.0
19.0, 19.0

p6

p6

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

MO000041437

MO000041125 e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c16 : 1
stoichiometry:c19 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 18262679 After the transient association of TLR3 with TICAM-1 through the TIR domains, TICAM-1 dissociates from TLR3 to form a speckle-like structure containing RIP1, TRAF3 and NAP1 where TICAM-1-mediated signaling is initiated.

Go back
657.0, 493.0
21.0, 21.0

p7

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_EndosomeLumen

--

e14

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18262679,15502848 In addition, phosphorylation of two specific tyrosine residues (Tyr759 and Tyr858) in the TIR domain of TLR3 is essential for dsRNA-induced signaling

Go back
346.0, 602.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000000065

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m18998*m17*0.1

nodelay

--

true

0

false

PMID:18262679 After the transient association of TLR3 with TICAM-1 through the TIR domains, TICAM-1 dissociates from TLR3 to form a speckle-like structure containing RIP1, TRAF3 and NAP1 where TICAM-1-mediated signaling is initiated. PMID: 18262679 RIP1 associates with TICAM-1 via the PHIM domain in the C-terminal region and acts as an NF-¦ÊB activator and apoptosis mediator in TICAM-1-mediated signaling. PMID: 18262679,15814722,15064760,14739303 Receptor-interacting protein 1 (RIP1), a kinase containing a death domain, associates with TICAM-1 via the RIP homotypic interaction motif (RHIM) domain in the C-terminal region and acts as an NF-¦ÊB inducer and apoptosis mediator in TICAM-1-mediated signaling

Go back
481.0, 569.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000016963 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m18998*m1872*m19*0.1

nodelay

--

true

0

false

PMID:18262679 After the transient association of TLR3 with TICAM-1 through the TIR domains, TICAM-1 dissociates from TLR3 to form a speckle-like structure containing RIP1, TRAF3 and NAP1 where TICAM-1-mediated signaling is initiated. PMID: 18262679,16306937,16306936 In addition, TRAF3 is involved in the TLR3-TICAM-1-mediated IRF-3 activation PMID: 18262679,15611223 It is reported that NF-¦ÊB activating kinase (NAK)-associated protein 1 (NAP1) participates in the recruitment of IRF-3 kinases to the N-terminal region of TICAM-1 PMID: 18262679 TRAF3 and NAP1 participate in the recruitment and activation of the IRF-3 kinases TBK1 and IKKvar epsilon.

Go back
689.0, 84.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 403.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
382.5503990018443, 422.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
127.86837732985626, 1050.4452121626266

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
425.9894241229342, 1237.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
412.8439679158143, 422.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
113.77201272554433, 1179.8962642732429

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
370.4739244227113, 1027.8340510294686

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
359.19717645097484, 446.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
127.91531931426964, 1014.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.82168482165287, 1239.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
113.19509937149269, 1184.4972196148292

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0, 460.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
369.6930369309187, 446.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
730.0, 1108.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.0, 953.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
757.6214926735981, 1079.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.81864999649, 1075.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.4928890024968, 891.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.8848002049721, 576.7748008455096

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 504.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.0, 512.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
625.0, 566.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.0, 612.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
633.0, 560.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
763.6132233653639, 628.8356563460532

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.2926937794119, 578.2909647972695

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.0, 99.26258603804887

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 612.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
330.0, 573.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
356.0, 621.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.77665766858627, 583.8771242648312

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 521.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.0, 533.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.4133125023502, 590.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
628.0, 622.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
644.0402649471412, 702.24549324357

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.6580753813449, 698.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
780.0, 93.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.4050814913675, 814.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
311.0, 882.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
394.8725795113394, 918.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.1676869865141, 701.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
304.0, 788.4043756496454

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
346.0, 781.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
146.5055000712813, 692.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.0, 708.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.0, 736.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.0, 769.5298221281347

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 160.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 773.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
538.0, 848.0

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
734.5019571832863, 800.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.0, 851.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
790.465257030206, 891.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
724.8632840217354, 941.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 453.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
571.8732413079431, 539.3444084952466

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
560.0, 533.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.6066663260746, 674.0

c49

c49

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
831.0, 233.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.0, 680.0

c50

c50

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
387.0, 959.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 1024.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 1091.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
647.6643604056492, 1027.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
584.0, 1054.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
745.0, 560.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.886569358273, 563.3423947843869

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
817.0, 565.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.0, 656.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
741.0, 287.1143318680631

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
923.0, 719.3767371852321

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.8989156063548, 706.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.3254370185559, 735.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.0, 794.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0769230769231, 833.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.0, 722.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
918.0, 766.0167694794915

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.0, 760.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
934.0, 763.5920564579087

c68

c68

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
658.7645740721151, 681.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
792.1117964514128, 280.6636527173945

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 742.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 801.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.7611400011626, 907.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.466355478943, 930.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 914.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
778.0, 1120.9836729236984

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
965.0, 1112.1481227520483

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
778.0, 1080.5777087639997

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
957.0, 1073.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.2987830845308, 281.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
774.0, 1031.3981843166116

c81

c81

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
989.0, 1024.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.79887605359005, 262.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.13108104165445, 259.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 333.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
318.0, 262.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
423.85994340570034, 316.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.0, 357.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.0, 324.810265188326

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.0072641641785, 163.41325584657966

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.0, 262.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.3474977942104, 325.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
642.0, 1134.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.99185428945, 1197.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 414.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
113.94617344720902, 1177.926459684428

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
317.66814185900927, 1121.2802632370212

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
300.2776907336067, 414.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
127.52482622568672, 1053.7160615370822

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.6976593413504, 1107.3750839245918

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back