1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18267068.csml convertedTime:2009.07.01.11:15

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Shared principles in NF-kappaB signaling.
Authors Hayden MS, Ghosh S.
Affiliation Department of Immunobiology, Yale University School of Medicine, New Haven, CT06510, USA.
Abstract The transcription factor NF-kappaB has served as a standard for inducibletranscription factors for more than 20 years. The numerous stimuli that activateNF-kappaB, and the large number of genes regulated by NF-kappaB, ensure thatthis transcription factor is still the subject of intense research. Here, weattempt to synthesize some of the basic principles that have emerged fromstudies of NF-kappaB, and we aim to generate a more unified view of NF-kappaBregulation.
PMID 18267068
Model Abstract

Entity

G028758:SERPINB5 MO000000001:PKAc MO000000058:NF-kappaB MO000000065:RIP1 MO000000192:c-Rel MO000000193:RelA-p65 MO000000196:p52 MO000000199:p105 MO000000200:p50 MO000000202:p100{p} MO000000203:NIK MO000000206:TNFR1 MO000000207:TRADD MO000000209:TRAF2 MO000000211:IKK-beta MO000000212:TRAF6 MO000000214:IL-1 MO000000233:IkappaB-alpha MO000000234:IkappaB-beta MO000000238:Bcl-3 MO000000277:p53 MO000000289:TNF-alpha MO000000291:20S proteasome MO000016573:MyD88 MO000016574:TAK1 MO000016599:IKK-gamma MO000016636:(p50)2 MO000016637:p52:p52 MO000016647:PKCzeta MO000016661:IKK-alpha:IKK-beta:(IKK-gamma)n MO000016752:PP2A MO000016882:LPS MO000016963:TRAF3 MO000016965:TRAF5 MO000017189:CREB MO000017332:GSK3beta MO000017396:CKII MO000017462:CBP MO000017874:cIAP-1 MO000017875:cIAP-2 MO000017949:RIP2 MO000018837:SCF-betaTrCP MO000019013:MSK1 MO000019394:TLR4 MO000019479:protein remnants MO000019984:p300 MO000021134:Hsp50 MO000021135:Hsp90 MO000022136:Ubc13 MO000022224:dsRNA MO000023574:HDAC3 MO000031185:SMRT MO000033291:IKK-alpha:IKK-beta MO000038331:IKK-alpha{p} MO000041125:TRIF MO000065270:ELKS MO000066987:DDX58 MO000069621:RPS3 MO000081711:p105{p} MO000094908:MAVS e1: e10: e100:IkappaB-zeta e101:IkappaB-zeta e102:IkappaB-zeta e103:(p50)2:IkappaB-zeta e104:IL-6 e105:IL-6:(p50)2:IkappaB-zeta e106:Ikappa-Balpha:p50:p65:PKAc e107:Ikappa-Balpha{p}:p50:p65:PKAc e108:p50:p65{p} e109:MSK2 e11:Ikappa-Balpha:p50:p65 e110:p50:p65{p}:CBP:p300 e111:p50:p65{p}{ace}:CBP:p300 e112:p50:p65 e113:p50:p65:SMRT:HDAC3 e114:IKK-alpha e115:p50:p65:SMRT{p}:HDAC3 e116:Histone H3:DNA e117:Histone H3{p}:DNA e118:CBP{p} e119:p50:p65:SMRT{p} e12:DNA e120:p53:CBP e121:CREB{p} e122:CREB:CBP e123:CREB:CBP{p} e124:p50:p65:RPS3 e125:COMMD1 e126:ECS-SOCS1 e127:p50:p65:COMMD1:ECS-SOCS1 e128:protein remnants e129:p50 e13:DNA:p52:p52 e130:TNF-alpha:TNFR1:TRADD:TRAF2IKK complex:RIP1{ub} e131:RIP1{ub}:Nemo{ub}:TRAF2:TRAdd:TNFR1:TNF e132:IKK-alpha:IKK-beta:(IKK-gamma)n {p} e133:IKK-alpha:IKK-beta:(IKK-gamma)n {p} e134:IKK-alpha{p}:IKK-beta{p} e135:PP2a:IKK-alpha{p}:IKK-beta{p} e136:PP2a:IKK-alpha:IKK-beta e137:TRAFs e138:NOD ligand complex:RIP2{ub} e14:RelA-p65:p100 e15:Ikappa-Balpha{p}{ub}:p50:p65:PKAc e16:p100 e17:PKAc:p65:p50 e18:UbcH5 e19:PKAc:p65{p}:p50 e2: e20:p50:p65{p} e21:genes e22:DNA:p50:p65 e23:IL-1:IL-1R e24:IL-1R e25:IL-1:IL-1R:MYD88 e26:dsRNA:DDX58 e27:dsRNA:DDX58:MAVS e28:IKK-alpha:IKK-beta:(IKK-gamma)2:Cdc37:Hsp-90 e29:TNF-alpha:TNFR1 e3: e30:TNF-alpha:TNFR1:TRADD e31:TNF-alpha:TNFR1:TRADD:TRAF2 e32:TNF-alpha:TNFR1:TRADD:TRAF5 e33:IL-1:IL-1R:MYD88:Traf6 e34:LPS:TLR4 e35:LPS:TLR4:MYD88 e36:LPS:TLR4:MYD88:TRAF6 e37:ligand:receptor complex e38:ligand:receptor complex:TRAF3 e39:IKK-alpha e4: e40:ligand:receptor complex:TRAF3:NIK e41:NIK{ub} e42:ligand:receptor complex:TRAF3{ub}:NIK e43:TNF-alpha:TNFR1:TRADD:RIP1:TRAF2 e44:TNF-alpha:TNFR1:TRADD:RIP1:IKK e45:TNF-alpha:TNFR1:TRADD:RIP1:IKK{active} e46:TNF-alpha:TNFR1:TRADD:TRAF2:IKK e47:TNF-alpha:TNFR1:TRADD:RIP1{ub}:TRAF2 e48:LPS:TLR4:TRIF e49:LPS:TLR4:TRIF:RIP1 e5:p50:p65 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Ikappa-Balpha:p50:p65 e60: e61: e62: e63:dsRNA:TLR3 e64:dsRNA:TLR3:TRIF e65:dsRNA:TLR3:TRIF:RIP1 e66:(IKK-alpha)2 e67:NF-kappaB{active} e68:ligand:TCR complex e69:ligand:BCR complex e7: e70:CBM complex e71:(IKK-gamma)n e72:NOD:ligand complex e73:NOD:ligand:RIP2 e74:NOD:ligand:RIP2:IKK e75:NOD:ligand:RIP2:IKK e76:(IKK-beta)2 e77:IKK-beta:IKK-gamma e78:IKK-alpha:IKK-gamma e79:IKK-alpha:IKK-beta:(IKK-gamma)n e8: e80:geladanamycin e81:IKK-alpha:IKK-beta:(IKK-gamma)2:ELKS e82:IKK-beta{p} e83:CBM oligomer e84:IkappaB-beta{p} e85:IkappaB-alpha e86:IkappaB-epsilon e87:IkappaB-beta e88:DNA:p50:p65:IkappaB-beta e89:p105:NF-kappaB e9: e90:(RelB)2 e91:p100:(RelB)2 e92:p100{p}:SCF-betaTRCP e93:p100{p}{ub}:SCF-betaTRCP e94:p52:(RelB)2 e95:p52:p52:BCL3 e96:BCL3:p50:p65 e97:(p50)2:BCL3 e98:Cyclin D1 e99:Hdm2

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
950.0, 1742.0
28.0, 28.0

SERPINB5

--

G028758

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p117

--

true true true true

csml-variable:Double

m107458

10

false

infinite

0

unit false false false
TRANSFACG028758

--

Go back
764.0, 780.0
32.0, 32.0

PKAc

--

MO000000001

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

p1

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
TRANSPATHMO000000001

--

Go back
1096.0, 948.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p50 p78

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
773.0, 205.0
30.0, 30.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39 p40 p45 p48

true true true true

csml-variable:Double

m43

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
1031.0, 1483.0
26.0, 26.0

c-Rel

--

MO000000192

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p120

true true true true

csml-variable:Double

m165

10

false

infinite

0

unit false false false
TRANSPATHMO000000192

--

Go back
951.0, 739.5
33.5, 33.5

RelA-p65

--

MO000000193

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m166

10

false

infinite

0

unit false false false
TRANSPATHMO000000193

--

Go back
880.0, 824.0
24.0, 24.0

p52

--

MO000000196

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

p5 p7

true true true true

csml-variable:Double

m168

10

false

infinite

0

unit false false false
TRANSPATHMO000000196

--

Go back
1169.0, 740.5
22.5, 22.5

p105

--

MO000000199

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76 p78

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
TRANSPATHMO000000199

--

Go back
1274.0, 914.0
28.0, 28.0

p50

--

MO000000200

cso30:c:Protein

cso30:i:CC_CellComponent

--

p77

--

true true true true

csml-variable:Double

m172

10

false

infinite

0

unit false false false
TRANSPATHMO000000200

--

Go back
906.0, 614.0
27.0, 27.0

p100{p}

--

MO000000202

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p81

true true true true

csml-variable:Double

m173

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
1186.0, 210.0
28.0, 28.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p34 p35 p57 p33 p58

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
791.0, 143.0
26.0, 26.0

TNFR1

--

MO000000206

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m177

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000000206

--

Go back
881.0, 201.0
30.0, 30.0

TRADD

--

MO000000207

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m178

10

false

infinite

0

unit false false false
InterProIPR000488
TRANSPATHMO000000207

--

Go back
960.0, 200.0
24.0, 24.0

TRAF2

--

MO000000209

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m180

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
796.0, 348.0
32.0, 32.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p61 p62 p68 p52 p71 p76 p99

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
418.0, 654.0
28.0, 28.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p31 p128

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
206.0, 518.0
20.0, 20.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
676.0, 772.0
24.0, 24.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
1206.0, 406.0
28.0, 28.0

IkappaB-beta

--

MO000000234

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71 p72

true true true true

csml-variable:Double

m200

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000234

--

Go back
1009.0, 1169.0
30.0, 30.0

Bcl-3

--

MO000000238

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84 p85 p86 p87 p88

true true true true

csml-variable:Double

m204

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000238

--

Go back
870.0, 1506.0
28.0, 28.0

p53

--

MO000000277

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p112

true true true true

csml-variable:Double

m220

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000277

--

Go back
829.0, 29.0
30.0, 30.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p66

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
1094.0, 858.0
28.0, 28.0

20S proteasome

--

MO000000291

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p77

true true true true

csml-variable:Double

m232

10

false

infinite

0

unit false false false
TRANSPATHMO000000291

--

Go back
409.0, 545.0
22.0, 22.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p30

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1395.0, 295.0
26.0, 26.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p123 p129

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
755.0, 471.0
25.0, 25.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62 p63 p51

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1146.0, 1250.0
28.0, 28.0

(p50)2

--

MO000016636

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86 p94 p95

true true true true

csml-variable:Double

m1621

10

false

infinite

0

unit false false false
TRANSPATHMO000016636

--

Go back
885.0, 1173.0
22.0, 22.0

p52:p52

--

MO000016637

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p6 p84

true true true true

csml-variable:Double

m1622

10

false

infinite

0

unit false false false
TRANSPATHMO000016637

--

Go back
399.0, 1219.0
34.0, 34.0

PKCzeta

--

MO000016647

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p102

true true true true

csml-variable:Double

m1631

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016647

--

Go back
666.0, 578.0
36.0, 36.0

IKK-alpha:IKK-beta:(IKK-gamma)n

--

MO000016661

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64

p21 p22 p27 p26 p40 p42 p53 p55 p65 p66 p67 p121

true true true true

csml-variable:Double

m1637

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1366.0, 240.0
26.0, 26.0

PP2A

--

MO000016752

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p126

true true true true

csml-variable:Double

m1703

10

false

infinite

0

unit false false false
TRANSPATHMO000016752

--

Go back
244.0, 184.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1106.0, 198.0
20.0, 20.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p35

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1039.0, 203.0
26.0, 26.0

TRAF5

--

MO000016965

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m1874

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016965

--

Go back
753.0, 1601.0
22.0, 22.0

CREB

--

MO000017189

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p113 p114 p115

true true true true

csml-variable:Double

m2057

10

false

infinite

0

unit false false false
InterProIPR003102
TRANSPATHMO000017189

--

Go back
792.0, 1724.0
24.0, 24.0

GSK3beta

--

MO000017332

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p113

true true true true

csml-variable:Double

m2177

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017332

--

Go back
415.0, 1435.0
26.0, 26.0

CKII

--

MO000017396

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p101

true true true true

csml-variable:Double

m2228

10

false

infinite

0

unit false false false
TRANSPATHMO000017396

--

Go back
972.0, 1576.0
32.0, 32.0

CBP

--

MO000017462

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p108 p112 p114

true true true true

csml-variable:Double

m2282

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000017462

--

Go back
1310.0, 218.0
28.0, 28.0

cIAP-1

--

MO000017874

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m2617

10

false

infinite

0

unit false false false
TRANSPATHMO000017874

--

Go back
1063.0, 283.0
26.0, 26.0

cIAP-2

--

MO000017875

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m2618

10

false

infinite

0

unit false false false
TRANSPATHMO000017875

--

Go back
1349.0, 1097.0
30.0, 30.0

RIP2

--

MO000017949

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m2684

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017949

--

Go back
961.0, 697.0
22.0, 22.0

SCF-betaTrCP

--

MO000018837

cso30:c:Protein

cso30:i:CC_CellComponent

--

p83

p11 p81

true true true true

csml-variable:Double

m3459

10

false

infinite

0

unit false false false
TRANSPATHMO000018837

--

Go back
1052.0, 1420.0
32.0, 32.0

MSK1

--

MO000019013

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p97

true true true true

csml-variable:Double

m3621

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019013

--

Go back
342.0, 206.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
470.0, 1134.0
20.0, 20.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p36 p38 p77 p79 p83

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1073.0, 1537.0
30.0, 30.0

p300

--

MO000019984

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p103

true true true true

csml-variable:Double

m4512

10

false

infinite

0

unit false false false
InterProIPR000433
TRANSPATHMO000019984

--

Go back
484.0, 496.0
24.0, 24.0

Hsp50

--

MO000021134

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m5515

10

false

infinite

0

unit false false false
InterProIPR004918
TRANSPATHMO000021134

--

Go back
560.0, 484.0
32.0, 32.0

Hsp90

--

MO000021135

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65

true true true true

csml-variable:Double

m5516

10

false

infinite

0

unit false false false
TRANSPATHMO000021135

--

Go back
1358.0, 982.0
24.0, 24.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p128

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
606.0, 211.0
28.0, 28.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p46

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1203.0, 1439.0
26.0, 26.0

HDAC3

--

MO000023574

cso30:c:Protein

cso30:i:CC_CellComponent

--

p110

p105

true true true true

csml-variable:Double

m7349

10

false

infinite

0

unit false false false
InterProIPR003084
TRANSPATHMO000023574

--

Go back
1243.0, 1503.0
34.0, 34.0

SMRT

--

MO000031185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p105

true true true true

csml-variable:Double

m10730

10

false

infinite

0

unit false false false
InterProIPR001005
TRANSPATHMO000031185

--

Go back
712.0, 420.0
24.0, 24.0

IKK-alpha:IKK-beta

--

MO000033291

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59 p125

p64

true true true true

csml-variable:Double

m11981

10

false

infinite

0

unit false false false
TRANSPATHMO000033291

--

Go back
979.0, 539.0
26.0, 26.0

IKK-alpha{p}

--

MO000038331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

p10

true true true true

csml-variable:Double

m16546

10

false

infinite

0

unit false false false
TRANSPATHMO000038331

--

Go back
416.0, 360.5
23.5, 23.5

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p44 p47

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
768.0, 732.0
23.0, 23.0

ELKS

--

MO000065270

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m40137

10

false

infinite

0

unit false false false
TRANSPATHMO000065270

--

Go back
419.0, 212.0
26.0, 26.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
1145.0, 1329.0
30.0, 30.0

RPS3

--

MO000069621

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p116

true true true true

csml-variable:Double

m44464

10

false

infinite

0

unit false false false
TRANSPATHMO000069621

--

Go back
1177.0, 873.0
22.0, 22.0

p105{p}

--

MO000081711

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

p77

true true true true

csml-variable:Double

m55989

10

false

infinite

0

unit false false false
TRANSPATHMO000081711

--

Go back
487.0, 283.0
26.0, 26.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
306.68090046599644, 107.87187403343779
1242.354558157694, 1803.898818444971

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
333.6509001315404, 117.44363218800311
1204.2220087191536, 1694.0017576202135

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
594.0, 1460.4705882352941
44.11764705882353, 23.529411764705884

IkappaB-zeta

--

e100

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p89 p90

p91 p92

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
487.0, 1663.6600000000003
33.11999999999999, 24.839999999999996

IkappaB-zeta

--

e101

cso30:c:Protein

cso30:i:CC_Cytosol

--

p91 p92

p93

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
595.0, 1519.6600000000003
33.11999999999999, 24.839999999999996

IkappaB-zeta

--

e102

cso30:c:Protein

cso30:i:CC_Cytosol

--

p93

p94 p95

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
668.5, 1563.4398972288495
23.334740319324645, 32.56010277115067

(p50)2:IkappaB-zeta

--

e103

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p94

--

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
770.0, 1421.5
60.0, 13.0

IL-6

--

e104

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p95

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
874.0, 1475.5
60.0, 17.0

IL-6:(p50)2:IkappaB-zeta

--

e105

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p95

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
727.0, 866.9411764705884
25.235294117647054, 42.05882352941176

Ikappa-Balpha:p50:p65:PKAc

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p9 p52 p70

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
667.0, 1010.7647058823532
25.941176470588232, 43.23529411764706

Ikappa-Balpha{p}:p50:p65:PKAc

--

e107

cso30:c:Complex

cso30:i:CC_Extracellular

--

p9 p52 p70

p11

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1160.0, 1530.314917127072
24.016574585635365, 26.68508287292817

p50:p65{p}

--

e108

cso30:c:Complex

cso30:i:CC_Cytosol

--

p97 p98

p15 p103

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1005.5, 1442.608573153552
21.824713221976257, 35.39142684644797

MSK2

--

e109

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p98

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
794.5, 1218.1526885667095
19.95723986052487, 27.847311433290518

Ikappa-Balpha:p50:p65

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1108.0, 1635.3823529411764
24.970588235294112, 41.617647058823536

p50:p65{p}:CBP:p300

--

e110

cso30:c:Complex

cso30:i:CC_Extracellular

--

p103

p104

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
918.0, 1687.1764705882354
20.29411764705882, 33.8235294117647

p50:p65{p}{ace}:CBP:p300

--

e111

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p104

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1244.0, 1378.314917127072
24.016574585635365, 26.68508287292817

p50:p65

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p105 p116 p118 p119

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
1221.0, 1550.8529411764705
21.088235294117645, 35.14705882352942

p50:p65:SMRT:HDAC3

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p105

p106 p111

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
956.0, 1644.0
24.0, 24.0

IKK-alpha

--

e114

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p106 p107 p108 p117 p119 p120

true true true true

csml-variable:Double

m117

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1162.0, 1647.205882352941
19.676470588235297, 32.794117647058826

p50:p65:SMRT{p}:HDAC3

--

e115

cso30:c:Complex

cso30:i:CC_Cytosol

--

p106

p110

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
642.0, 1615.5
60.0, 17.0

Histone H3:DNA

--

e116

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p107

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
709.0, 1700.3709179737723
53.39676009256878, 15.129082026227824

Histone H3{p}:DNA

--

e117

cso30:c:Complex

cso30:i:CC_Cytosol

--

p107

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
1041.0, 1567.7073170731708
30.365853658536583, 24.29268292682927

CBP{p}

--

e118

cso30:c:Protein

cso30:i:CC_Cytosol

--

p108

p103 p112 p115

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
1037.5, 1685.4039273261153
20.493852082951, 28.596072673885118

p50:p65:SMRT{p}

--

e119

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p110

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
822.0, 1189.5
60.0, 13.0

DNA

--

e12

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p6 p15

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
916.5, 1593.6647225462425
23.140476587235455, 28.335277453757705

p53:CBP

--

e120

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p112

--

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
747.0, 1506.3902439024391
34.512195121951216, 27.609756097560975

CREB{p}

--

e121

cso30:c:Protein

cso30:i:CC_Cytosol

--

p113

p114

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
796.0, 1514.9779005524863
23.419889502762437, 26.022099447513828

CREB:CBP

--

e122

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p114

--

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
858.0, 1735.7900552486187
28.988950276243095, 32.20994475138122

CREB:CBP{p}

--

e123

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p115

--

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
1197.5, 1400.8623600660671
21.59864195265186, 30.13763993393283

p50:p65:RPS3

--

e124

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p116

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
951.0, 1334.557530402245
18.825070159027128, 43.442469597754915

COMMD1

--

e125

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p118

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
970.5, 1474.881446136906
18.71829693521747, 26.118553863094146

ECS-SOCS1

--

e126

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p118

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
669.0, 1333.088235294117
22.147058823529417, 36.91176470588236

p50:p65:COMMD1:ECS-SOCS1

--

e127

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p118

--

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
1013.0, 1733.0
21.0, 21.0

protein remnants

--

e128

cso30:c:Protein

cso30:i:CC_CellComponent

--

p119 p120

--

true true true true

csml-variable:Double

m131

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
922.0, 1218.0
28.0, 28.0

p50

--

e129

cso30:c:Protein

cso30:i:CC_CellComponent

--

p119

--

true true true true

csml-variable:Double

m132

10

false

infinite

0

unit false false false
TRANSPATHMO000000200

--

Go back
866.0, 1295.5
60.0, 17.0

DNA:p52:p52

--

e13

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p6

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
772.0, 264.6176470588236
23.029411764705877, 38.38235294117648

TNF-alpha:TNFR1:TRADD:TRAF2IKK complex:RIP1{ub}

--

e130

cso30:c:Complex

cso30:i:CC_Cytosol

--

p121

p122

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
895.0, 262.6470588235294
25.411764705882355, 42.35294117647059

RIP1{ub}:Nemo{ub}:TRAF2:TRAdd:TNFR1:TNF

--

e131

cso30:c:Complex

cso30:i:CC_Extracellular

--

p122

p123

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
1346.0, 454.0
36.0, 36.0

IKK-alpha:IKK-beta:(IKK-gamma)n {p}

--

e132

cso30:c:Protein

cso30:i:CC_CellComponent

--

p123

p124

true true true true

csml-variable:Double

m135

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1358.0, 598.0
36.0, 36.0

IKK-alpha:IKK-beta:(IKK-gamma)n {p}

--

e133

cso30:c:Protein

cso30:i:CC_CellComponent

--

p124

p125

true true true true

csml-variable:Double

m136

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
1585.0, 810.2099447513813
25.011049723756905, 27.790055248618792

IKK-alpha{p}:IKK-beta{p}

--

e134

cso30:c:Complex

cso30:i:CC_Extracellular

--

p125

p126

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
1618.5, 639.022572949165
19.333822719765095, 26.97742705083502

PP2a:IKK-alpha{p}:IKK-beta{p}

--

e135

cso30:c:Complex

cso30:i:CC_Extracellular

--

p126

p127

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
1682.6341530556065, 838.2097632593137
19.199669664158563, 26.790236740686368

PP2a:IKK-alpha:IKK-beta

--

e136

cso30:c:Complex

cso30:i:CC_Extracellular

--

p127

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
1321.5, 1409.6844435500102
17.461259810827126, 28.315556449989945

TRAFs

--

e137

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p129

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
1401.5, 1244.3228115250506
21.985318407047163, 30.677188474949535

NOD ligand complex:RIP2{ub}

--

e138

cso30:c:Complex

cso30:i:CC_Cytosol

--

p128

--

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
964.5, 966.9145142476254
22.11981336443926, 27.08548575237461

RelA-p65:p100

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p8

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
661.0, 1161.5000000000002
22.499999999999996, 37.49999999999999

Ikappa-Balpha{p}{ub}:p50:p65:PKAc

--

e15

cso30:c:Complex

cso30:i:CC_Extracellular

--

p11

p12

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
906.0, 466.0
27.0, 27.0

p100

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p80 p4

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
547.5, 1226.072490365205
25.03138190493669, 34.9275096347954

PKAc:p65:p50

--

e17

cso30:c:Complex

cso30:i:CC_Extracellular

--

p12

p96 p99 p100 p101 p102

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
512.0, 1018.2091970215333
32.90400482994566, 20.29080297846649

UbcH5

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
515.5, 1354.9093411635165
24.431638832813356, 34.09065883648376

PKAc:p65{p}:p50

--

e19

cso30:c:Complex

cso30:i:CC_Extracellular

--

p96 p100 p101 p102

p13 p99

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
306.68090046599644, 107.87187403343779
1242.354558157694, 1803.898818444971

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1160.0, 1406.314917127072
24.016574585635365, 26.68508287292817

p50:p65{p}

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p73 p74 p85 p97 p98

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
837.0, 1597.6262975778548
38.200692041522494, 20.37370242214533

genes

--

e21

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p14

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
746.0, 1391.5
60.0, 17.0

DNA:p50:p65

--

e22

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p15

p14 p75

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
346.5, 578.8235036176277
18.174523130892347, 35.176496382372285

IL-1:IL-1R

--

e23

cso30:c:Complex

cso30:i:CC_Extracellular

--

p16

p17 p89 p91

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
340.5, 493.6555360281196
23.62390158172232, 36.344463971880494

IL-1R

--

e24

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p16

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
343.5, 634.654064966049
25.331253440998356, 35.34593503395119

IL-1:IL-1R:MYD88

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p22 p28

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
498.0, 244.4033149171271
20.33701657458563, 22.596685082872924

dsRNA:DDX58

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
564.5, 328.768397871169
15.932648192328875, 22.231602128830986

dsRNA:DDX58:MAVS

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p21

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
553.0, 634.1176470588235
21.529411764705884, 35.88235294117647

IKK-alpha:IKK-beta:(IKK-gamma)2:Cdc37:Hsp-90

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
850.5, 134.96820872615655
18.099758824819116, 35.03179127384345

TNF-alpha:TNFR1

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p23

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
331.5279916291502, 132.71896519659163
1192.6603758313865, 1754.204636118664

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
921.5, 136.87337126078177
21.590750596439708, 30.1266287392182

TNF-alpha:TNFR1:TRADD

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p24 p25

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
998.0, 134.88235294117646
20.47058823529412, 34.11764705882354

TNF-alpha:TNFR1:TRADD:TRAF2

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p27 p39 p42

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1077.0, 133.82352941176475
21.705882352941174, 36.1764705882353

TNF-alpha:TNFR1:TRADD:TRAF5

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
342.0, 699.9117647058823
19.85294117647059, 33.08823529411765

IL-1:IL-1R:MYD88:Traf6

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
343.5, 256.4937513703135
16.278228458671343, 31.50624862968648

LPS:TLR4

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p30 p44 p90 p92

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
341.5, 308.6531473664895
21.74857772068269, 30.346852633510736

LPS:TLR4:MYD88

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
353.0, 365.52941176470586
21.882352941176475, 36.47058823529412

LPS:TLR4:MYD88:TRAF6

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1153.5, 135.39070379302785
21.49813637360228, 41.609296206972154

ligand:receptor complex

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p32

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1193.5, 141.50302807854666
20.42282987704166, 28.496971921453483

ligand:receptor complex:TRAF3

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32 p38

p34

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1000.0, 420.0
24.0, 24.0

IKK-alpha

--

e39

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57 p59 p60 p63 p70 p72 p100

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
377.49511028098544, 176.2013747321107
1100.7261385277168, 1667.239817047625

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1261.0, 137.20588235294122
22.676470588235297, 37.794117647058826

ligand:receptor complex:TRAF3:NIK

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p37

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1210.0, 350.55773268019595
35.79426172148356, 27.442267319804056

NIK{ub}

--

e41

cso30:c:Protein

cso30:i:CC_Cytosol

--

p35 p33 p58

p36

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1310.0, 142.44117647058826
20.735294117647058, 34.55882352941177

ligand:receptor complex:TRAF3{ub}:NIK

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
718.0, 138.44117647058818
20.73529411764706, 34.55882352941177

TNF-alpha:TNFR1:TRADD:RIP1:TRAF2

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p43

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
622.0, 139.1764705882353
20.294117647058826, 33.8235294117647

TNF-alpha:TNFR1:TRADD:RIP1:IKK

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

p41

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
560.0, 132.02941176470586
23.382352941176467, 38.970588235294116

TNF-alpha:TNFR1:TRADD:RIP1:IKK{active}

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
485.0, 133.7941176470588
22.323529411764707, 37.20588235294118

TNF-alpha:TNFR1:TRADD:TRAF2:IKK

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
425.0, 134.5588235294117
21.264705882352942, 35.441176470588246

TNF-alpha:TNFR1:TRADD:RIP1{ub}:TRAF2

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43 p123

p121

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
343.5, 146.4888970453294
25.449623784180584, 35.51110295467059

LPS:TLR4:TRIF

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p45

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
381.0, 137.5294117647059
21.88235294117647, 36.47058823529412

LPS:TLR4:TRIF:RIP1

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p50

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
613.5, 875.1743042826198
21.090984835860688, 25.82569571738044

p50:p65

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
569.6581658453705, 1131.1781493455373
725.2063867002842, 657.6825145680428

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
647.9858575187712, 1146.7642688208146
424.04991699048264, 637.4253529283696

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
579.1115079438845, 1139.9562527227292
706.2997025032569, 640.1263078136594

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
580.461985386529, 1141.3067301653732
703.5987476179668, 637.4253529283696

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
569.6581658453705, 1131.1781493455373
725.2063867002842, 657.6825145680428

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
569.6581658453705, 1131.1781493455373
725.2063867002842, 657.6825145680428

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
580.461985386529, 1141.3067301653732
703.5987476179668, 637.4253529283696

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1099.0453233621515, 1401.273637874508
45.30691039158763, 41.01467677554258

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
980.203308409404, 1590.3404798447864
128.29535705126074, 116.14106006745732

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
569.6581658453705, 1131.1781493455373
725.2063867002842, 657.6825145680428

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
836.5, 867.6160763442837
23.20847861993027, 32.38392365571666

Ikappa-Balpha:p50:p65

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
740.5852307351533, 1423.446824344217
22.96622068794527, 11.057809960862546

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
739.8183236186215, 1390.4698183333487
78.60797944451625, 141.49436300012925

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
772.7953296294932, 1482.4986723171735
12.270513864509844, 12.270513864509853

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1497.5, 311.9563692172769
21.205875904406927, 41.043630782723085

dsRNA:TLR3

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p47

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1495.5, 398.41181868232707
25.504863277665624, 35.58818131767297

dsRNA:TLR3:TRIF

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1490.0, 526.2941176470589
20.823529411764703, 34.70588235294118

dsRNA:TLR3:TRIF:RIP1

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p49

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1066.5, 563.6753874354274
26.398433594400935, 32.32461256457257

(IKK-alpha)2

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
1116.0, 1100.0
24.0, 24.0

NF-kappaB{active}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p50 p79

--

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1496.5, 698.377768033326
22.021486516114887, 42.62223196667397

ligand:TCR complex

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p69

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
1501.5, 936.8901556676168
20.20675290506468, 39.10984433238325

ligand:BCR complex

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p69

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
323.00362728264747, 115.13090548283753
1218.3627676416982, 1726.3885711232936

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1415.5, 706.3477702330705
24.83409799963296, 34.65222976692971

CBM complex

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p69

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
513.0, 396.18784530386745
21.43093922651934, 23.8121546961326

(IKK-gamma)n

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51 p125

p64

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1311.5, 1268.8550241626397
24.618396933844355, 30.14497583736044

NOD:ligand complex

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p54

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1285.5, 1125.9304459533862
20.83318040007341, 29.069554046614062

NOD:ligand:RIP2

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p55 p128

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1210.0, 1079.205882352941
19.67647058823529, 32.794117647058826

NOD:ligand:RIP2:IKK

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p129

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1258.0, 1235.205882352941
19.67647058823529, 32.794117647058826

NOD:ligand:RIP2:IKK

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p129

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
974.0, 348.61325966850814
27.34806629834254, 30.38674033149171

(IKK-beta)2

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
799.5, 592.915014164306
24.56940509915014, 30.084985835694052

IKK-beta:IKK-gamma

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
861.5, 535.3242792867856
20.968505249125144, 25.675720713214467

IKK-alpha:IKK-gamma

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
450.0, 942.0
36.0, 36.0

IKK-alpha:IKK-beta:(IKK-gamma)n

--

e79

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21 p22 p27 p26 p53 p66

p9

true true true true

csml-variable:Double

m81

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
327.35635443375435, 145.59999554058572
1168.789920729648, 1697.0829648994486

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
206.0, 1051.0
60.0, 34.0

geladanamycin

--

e80

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p66

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
1066.0, 659.7941176470588
19.323529411764707, 32.205882352941174

IKK-alpha:IKK-beta:(IKK-gamma)2:ELKS

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
615.0, 330.68292682926835
34.146341463414636, 27.317073170731707

IKK-beta{p}

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

p68

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
1416.0, 846.2651933701655
24.96132596685083, 27.734806629834253

CBM oligomer

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

p53

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1210.0, 513.5365853658536
36.829268292682926, 29.46341463414634

IkappaB-beta{p}

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

p71 p72

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
692.0, 1285.9896193771629
39.39446366782008, 21.01038062283737

IkappaB-alpha

--

e85

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p73

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
891.0, 1333.1314878892733
41.00346020761246, 21.868512110726645

IkappaB-epsilon

--

e86

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p74

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
610.0, 1374.0
28.0, 28.0

IkappaB-beta

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75

true true true true

csml-variable:Double

m89

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000234

--

Go back
673.0, 1436.3709179737723
53.39676009256878, 15.129082026227824

DNA:p50:p65:IkappaB-beta

--

e88

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p75

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
1295.5, 736.5952341276455
25.647225462422924, 31.404765872354606

p105:NF-kappaB

--

e89

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

p79

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
338.96362683670617, 176.06908559833394
1163.453753620047, 1674.8261470653065

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1195.5, 580.5250791534745
24.88785202466255, 30.474920846525578

(RelB)2

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p80 p7

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
1262.5, 554.5160579922923
19.69682510552395, 27.48394200770783

p100:(RelB)2

--

e91

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
1095.0, 613.9337016574584
25.259668508287294, 28.06629834254144

p100{p}:SCF-betaTRCP

--

e92

cso30:c:Complex

cso30:i:CC_Cytosol

--

p81

p82

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
1242.0, 612.8342541436464
27.149171270718234, 30.16574585635359

p100{p}{ub}:SCF-betaTRCP

--

e93

cso30:c:Complex

cso30:i:CC_Cytosol

--

p82

p83

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
1014.5, 1038.3068452927143
19.846760873554782, 27.693154707285743

p52:(RelB)2

--

e94

cso30:c:Complex

cso30:i:CC_Extracellular

--

p7

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1096.5, 1216.1246100201872
22.127362818865848, 30.875389979812812

p52:p52:BCL3

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
979.5, 1270.8632776656268
25.181317672967516, 35.13672233437328

BCL3:p50:p65

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p85

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1200.5, 1288.0255092677558
22.198385024775185, 30.97449073224445

(p50)2:BCL3

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
1022.0, 1350.733564013841
36.12456747404845, 19.266435986159173

Cyclin D1

--

e98

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p87

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
1075.0, 1340.2456747404847
42.66435986159169, 22.75432525951557

Hdm2

--

e99

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p88

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
679.0, 879.0
17.0, 17.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000000233 MO000000001

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c269 : 1
stoichiometry:c270 : 1

m5*m199*m108*0.1

nodelay

--

true

0

false

PMID: 18267068 I¦ÊB¦Á is rapidly degraded during activation of canonical NF-¦ÊB signaling pathways leading to the release of multiple NF-¦ÊB dimers, although the p65:p50 heterodimer is likely the primary target of I¦ÊB¦Á. PMID: 18267068, 9660950 PKA exists in a complex with cytosolic NF-¦ÊB:I¦ÊB complexes and following degradation of I¦ÊB¦Á phosphorylates p65 at Ser276, promoting the interaction of p65 with the transcriptional coactivators CBP (CREB-binding protein) and p300

Go back
909.0, 541.0
21.0, 21.0

p10

p10

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e16 MO000038331

MO000000202

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c91 : 1
stoichiometry:c24 : 1

m16*m16546*0.1

nodelay

--

true

0

false

PMID: 18267068 The noncanonical pathway, conversely, depends only on the IKK¦Á subunit, which functions by phosphorylating p100 and causing its inducible processing to p52.

Go back
535.0, 1295.0
17.0, 17.0

p100

p100

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e17 e39

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c284 : 1
stoichiometry:c283 : 1

m17*m39*0.1

nodelay

--

true

0

false

PMID: 18267068, 15122352, 17072324 IKK¦Á and IKK¦Â have been implicated in the direct phosphorylation of p65 at Ser536

Go back
445.0, 1260.5
22.5, 22.5

p101

p101

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e17 MO000017396

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c285 : 1
stoichiometry:c287 : 1
stoichiometry:c286 : 1

m17*m2228*0.1

nodelay

--

true

0

false

PMID: 18267068, 9405476, 10938077 Ser529 of p65 may also be inducibly phosphorylated by CK2 following IL-1 or TNF-¦Á stimulation, although it is unclear whether Ser529 phosphorylation affects transcription

Go back
457.0, 1361.0
21.0, 21.0

p102

p102

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e17 MO000016647

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c290 : 1
stoichiometry:c289 : 1

m17*m1631*0.1

nodelay

--

true

0

false

PMID: 18267068, 12881425 PKC¦Æ can phosphorylate p65 at Ser311, and CBP fails to associate with p65 following stimulation of PKC¦Æ-deficient cells

Go back
1109.0, 1581.0
21.0, 21.0

p103

p103

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e108 MO000019984 e118

e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c291 : 1
stoichiometry:c293 : 1
stoichiometry:c309 : 1
stoichiometry:c294 : 1

m111*m4512*m121*0.1

nodelay

--

true

0

false

PMID: 18267068, 9660950 PKA exists in a complex with cytosolic NF-¦ÊB:I¦ÊB complexes and following degradation of I¦ÊB¦Á phosphorylates p65 at Ser276, promoting the interaction of p65 with the transcriptional coactivators CBP (CREB-binding protein) and p300. PMID: 18267068, 17434128 It was recently reported that IKK¦Á phosphorylates CBP in a stimulus-dependent manner, inducing upregulation of CBP activity, increased binding to p65, and decreased binding to p53

Go back
1053.0, 1645.0
21.0, 21.0

p104

p104

cso30:i:ME_Acetylation

cso30:i:CC_Nucleoplasm

--

e110

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c296 : 1

m113*0.1

nodelay

--

true

0

false

PMID: 18267068, 15122352 Acetylation of p65, probably by CBP/p300 and associated HATs, occurs in the nucleus and is associated with increased transcription PMID: 18267068 p65 phosphorylation is necessary to recruit CBP/p300 allowing acetylation at Lys310

Go back
1251.0, 1442.5
18.5, 18.5

p105

p105

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e112 MO000031185 MO000023574

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c298 : 1
stoichiometry:c300 : 1
stoichiometry:c299 : 1

m115*m10730*m7349*0.1

nodelay

--

true

0

false

PMID: 18267068, 16382138 One possibility is that Ser536 phosphorylation alters the interaction of p65 with the SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor complex such that the level of HDAC3 is decreased and CBP/p300 is increased.

Go back
1207.0, 1611.0
17.0, 17.0

p106

p106

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e113 e114

e115

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c303 : 1
stoichiometry:c302 : 1

m116*m117*0.1

nodelay

--

true

0

false

PMID: 18267068, 16382138 In addition to p65 phosphorylation, IKK¦Á also may promote Lys310 acetylation through direct phosphorylation of SMRT, which leads to displacement of HDAC3 from the SMRT corepressor complex.

Go back
685.0, 1656.5
14.5, 14.5

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e116 e114

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c304 : 1
stoichiometry:c306 : 1
stoichiometry:c305 : 1

m119*m117*0.1

nodelay

--

true

0

false

PMID: 18267068, 12789343, 12789342 IKK¦Á is found associated with the ¦ÊB sites of some NF-¦ÊB-responsive genes, and stimulus-induced phosphorylation of histone H3 on serine 10 does not occur in the absence of IKK¦Á

Go back
940.0, 1511.5
16.5, 16.5

p108

p108

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017462 e114

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c292 : 1
stoichiometry:c308 : 1
stoichiometry:c307 : 1

m2282*m117*0.1

nodelay

--

true

0

false

PMID: 18267068, 17434128 In addition to the SMRT and N-CoR (nuclear receptor corepressor) complexes, IKK¦Á also has been shown to phosphorylate the CBP coactivator

Go back
138.0, 1262.0
19.0, 19.0

p109

p109

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

--

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0

1.0*0.1

nodelay

--

true

0

false

--

Go back
669.0, 1121.0
21.0, 21.0

p11

p11

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e18 MO000018837 e107

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c195 : 1
stoichiometry:c25 : 1

m18*m3459*m110*0.1

nodelay

--

true

0

false

PMID: 18267068, 17072324 Phosphorylation of the conserved serine residues (DS*GXXS*) in I¦ÊB proteins results in their K48-linked polyubiquitination by ¦ÂTrCP containing Skp1-Culin-Roc1/Rbx1/Hrt-1-F-box (SCF) E3 ubiquitin ligase complexes (SCF¦ÂTrCP) coordinately with the E2 UbcH5.

Go back
1101.0, 1689.0
21.0, 21.0

p110

p110

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e115

e119 MO000023574

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c311 : 1
stoichiometry:c312 : 1

m118*0.1

nodelay

--

true

0

false

PMID: 18267068, 16382138 In addition to p65 phosphorylation, IKK¦Á also may promote Lys310 acetylation through direct phosphorylation of SMRT, which leads to displacement of HDAC3 from the SMRT corepressor complex.

Go back
1165.0, 1585.0
21.0, 21.0

p111

p111

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e113

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18267068 Figure.4

Go back
917.0, 1537.0
21.0, 21.0

p112

p112

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000017462 MO000000277 e118

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c315 : 1
stoichiometry:c316 : 1
stoichiometry:c317 : 1
stoichiometry:c314 : 1

m2282*m220*0.1

nodelay

--

true

0

false

PMID: 18267068, 17434128 It was recently reported that IKK¦Á phosphorylates CBP in a stimulus-dependent manner, inducing upregulation of CBP activity, increased binding to p65, and decreased binding to p53

Go back
754.0, 1557.5
20.5, 20.5

p113

p113

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000017189 MO000017332

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c318 : 1
stoichiometry:c320 : 1
stoichiometry:c319 : 1

m2057*m2177*0.1

nodelay

--

true

0

false

PMID: 18267068, 16007092 GSK3¦Â, normally constitutively active, phosphorylates and inactivates CREB disrupting the interaction between CREB and CBP

Go back
799.0, 1559.0
17.0, 17.0

p114

p114

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000017189 MO000017462 e121

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c321 : 1
stoichiometry:c322 : 1
stoichiometry:c324 : 1
stoichiometry:c323 : 1

m2057*m2282*0.1

nodelay

--

true

0

false

PMID: 18267068, 16007092 GSK3¦Â, normally constitutively active, phosphorylates and inactivates CREB disrupting the interaction between CREB and CBP

Go back
849.0, 1681.0
21.0, 21.0

p115

p115

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000017189 e118

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c325 : 1
stoichiometry:c326 : 1
stoichiometry:c327 : 1

m2057*m121*0.1

nodelay

--

true

0

false

PMID: 18267068 One potential explanation is that CBP bound to CREB is a poor substrate for IKK¦Á phosphorylation, and that CBP phosphorylated by IKK¦Á binds poorly to CREB.

Go back
1196.0, 1364.0
23.0, 23.0

p116

p116

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e112 MO000069621

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c328 : 1
stoichiometry:c329 : 1
stoichiometry:c330 : 1

m115*m44464*0.1

nodelay

--

true

0

false

PMID: 18267068, 18045535 One recent and intriguing addition to this list is ribosomal protein S3 (RPS3), which seems to be required for the binding of NF-¦ÊB at specific ¦ÊB sites

Go back
970.0, 1702.0
19.0, 19.0

p117

p117

cso30:i:ME_GeneExpression

cso30:i:CC_Cytoplasm

--

e114

G028758

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c331 : 1
stoichiometry:c332 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18267068, 17377533 IKK¦Á represses transcription of the tumor suppressor Maspin by acting at the maspin promoter strongly supports a direct mechanism of action by IKK¦Á that is independent of NF-¦ÊB

Go back
958.0, 1406.0
19.0, 19.0

p118

p118

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e125 e126 e112

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c333 : 1
stoichiometry:c334 : 1
stoichiometry:c335 : 1
stoichiometry:c336 : 1

m128*m129*m115*0.1

nodelay

--

true

0

false

PMID: 18267068, 17183367 Although the exact mechanism of action remains unclear, it has recently been shown that targeting the SOCS-1-containing ubiquitin ligase complex (ECSSOCS1) to p65-containing dimers is carried out by COMMD1 (Copper Metabolism MURR1 Domain containing-1) proteins

Go back
806.0, 1666.0
19.0, 19.0

p119

p119

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

e112 e114

e128 e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c340 : 1
stoichiometry:c338 : 1
stoichiometry:c339 : 1

m115*m117*0.1

nodelay

--

true

0

false

PMID: 18267068, 15858576, 16116086 IKK¦Á is also involved in termination of inflammatory transcriptional responses in macrophages, possibly by promoting the nuclear degradation of both p65 and c-Rel

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574.0, 1170.0
19.0, 19.0

p12

p12

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e15

MO000019479 e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 18267068, 17072324 Phosphorylation of the conserved serine residues (DS*GXXS*) in I¦ÊB proteins results in their K48-linked polyubiquitination by ¦ÂTrCP containing Skp1-Culin-Roc1/Rbx1/Hrt-1-F-box (SCF) E3 ubiquitin ligase complexes (SCF¦ÂTrCP) coordinately with the E2 UbcH5.

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1013.0, 1529.0
21.0, 21.0

p120

p120

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytoplasm

--

MO000000192 e114

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c341 : 1
stoichiometry:c343 : 1
stoichiometry:c342 : 1

m165*m117*0.1

nodelay

--

true

0

false

PMID: 18267068, 15858576, 16116086 IKK¦Á is also involved in termination of inflammatory transcriptional responses in macrophages, possibly by promoting the nuclear degradation of both p65 and c-Rel

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646.0, 274.0
19.0, 19.0

p121

p121

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e47 MO000016661

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c344 : 1
stoichiometry:c345 : 1
stoichiometry:c346 : 1

m48*m1637*0.1

nodelay

--

true

0

false

PMID: 18267068, 16547522 RIP also becomes rapidly ubiquitinated following TNF¦Á stimulation, and it has been proposed that it is through this posttranslational modification that RIP1 binds to NEMO.

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832.0, 272.0
23.0, 23.0

p122

p122

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e130

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c347 : 1
stoichiometry:c348 : 1

m133*0.1

nodelay

--

true

0

false

PMID: 18267068 Conformational changes in the IKK complex induced by binding of NEMO to RIP, and/or ubiquitination of NEMO, lead to the exposure of IKK kinase domain and T loop serines and consequent transautophosphorylation or phosphorylation by an IKK-K such as TAK1.

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1037.0, 348.0
19.0, 19.0

p123

p123

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e131 MO000016574

e132 e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c349 : 1
stoichiometry:c352 : 1
stoichiometry:c350 : 1
stoichiometry:c351 : 1

m134*m1573*0.1

nodelay

--

true

0

false

PMID: 18267068 Conformational changes in the IKK complex induced by binding of NEMO to RIP, and/or ubiquitination of NEMO, lead to the exposure of IKK kinase domain and T loop serines and consequent transautophosphorylation or phosphorylation by an IKK-K such as TAK1.

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1366.0, 542.0
19.0, 19.0

p124

p124

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e132

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c353 : 1
stoichiometry:c354 : 1

m135*0.1

nodelay

--

true

0

false

PMID: 18267068 The active IKK then phosphorylates downstream substrates, including serine 740 within the IKK NBD and serine 68 in NEMO.

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1330.0, 674.0
19.0, 19.0

p125

p125

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e133

MO000033291 e71 e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c355 : 1
stoichiometry:c356 : 1
stoichiometry:c357 : 1
stoichiometry:c358 : 1

m136*0.1

nodelay

--

true

0

false

PMID: 18267068 NEMO phosphorylation results in the separation of stable NEMO dimers and NEMO binding to IKK.

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1597.0, 750.0
17.0, 17.0

p126

p126

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e134 MO000016752

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c359 : 1
stoichiometry:c360 : 1
stoichiometry:c361 : 1

m137*m1703*0.1

nodelay

--

true

0

false

PMID: 18267068, 16126728, 17188031 the protein phosphatase 2A (PP2A) has been shown to associate with IKK and potentiate IKK activation in cells

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1701.0, 762.0
17.0, 17.0

p127

p127

cso30:i:ME_Dephosphorylation

cso30:i:CC_Extracellular

--

e135

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c363 : 1

m138*0.1

nodelay

--

true

0

false

PMID: 18267068, 16126728, 14585847, 17977820 structural changes induced by NEMO Ser68 and IKK NBD phosphorylation may allow dephosphorylation of the activation loop serines in IKKs as well as N-terminal phosphorylation sites in NEMO by PP2A or PP2C¦Â

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1403.0, 1159.0
17.0, 17.0

p128

p128

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000212 MO000022136 e73

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c366 : 1
stoichiometry:c367 : 1
stoichiometry:c364 : 1
stoichiometry:c365 : 1

m183*m6443*m75*0.1

nodelay

--

true

0

false

PMID: 18267068, 17947236, 18079694, 17277144 Similar to RIP1, the kinase activity of RIP2 does not appear to be required, and RIP2 is also ubiquitinated through the action of Ubc13/TRAF6

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1158.0, 1142.0
19.0, 19.0

p129

p129

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e74 MO000016574 e137

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c368 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c369 : 1

m76*m1573*m140*0.1

nodelay

--

true

0

false

PMID: 18267068, 17562858, 17965022 RIP2 acts with TAK1 and TRAFs to induce NEMO ubiquitination and downstream signaling pathways

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619.0, 1207.0
17.0, 17.0

p13

p13

cso30:i:ME_Translocation

cso30:i:CC_Nucleoplasm

--

e19

e20 MO000000001

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c33 : 1
stoichiometry:c272 : 1

m19*0.1

nodelay

--

true

0

false

PMID: 18267068, 17072323 The released NF-¦ÊB dimers bind promoter and enhancer regions containing ¦ÊB consensus sequences 5¡ì GGGRNWYYCC 3¡ì (N¡½any base; R¡½purine; W¡½adenine or thymine; and Y¡½pyrimidine)

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845.0, 1533.0
21.0, 21.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c34 : 1

m22*0.1

nodelay

--

true

0

false

Go back
762.0, 1306.0
19.0, 19.0

p15

p15

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e12 e108

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c279 : 1
stoichiometry:c38 : 1

m12*m111*0.1

nodelay

--

true

0

false

PMID: 18267068, 17072323 The released NF-¦ÊB dimers bind promoter and enhancer regions containing ¦ÊB consensus sequences 5¡ì GGGRNWYYCC 3¡ì (N¡½any base; R¡½purine; W¡½adenine or thymine; and Y¡½pyrimidine)

Go back
267.0, 531.0
17.0, 17.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000214 e24

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m185*m24*0.1

nodelay

--

true

0

false

PMID: 18267068 Thus when IL-1R binds IL-1 or RIG-I binds cytoplasmic dsRNA they activate overlapping but unique signaling pathways due to these differences in upstream signaling components, and hence they induce distinct transcriptional programs.

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427.0, 587.0
17.0, 17.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016573

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m23*m1572*0.1

nodelay

--

true

0

false

PMID: 18267068, 17047224 For example, IL-1R and RIG-I, which both signal through TRAF6 to IKK, do so through distinct receptor proximal adaptor components MyD88 and MAVS, respectively

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522.0, 215.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 MO000022224

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m41844*m119368*0.1

nodelay

--

true

0

false

PMID: 18267068 Thus when IL-1R binds IL-1 or RIG-I binds cytoplasmic dsRNA they activate overlapping but unique signaling pathways due to these differences in upstream signaling components, and hence they induce distinct transcriptional programs.

Go back
564.0, 269.0
15.0, 15.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000094908

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m26*m68199*0.1

nodelay

--

true

0

false

PMID: 18267068, 17047224 For example, IL-1R and RIG-I, which both signal through TRAF6 to IKK, do so through distinct receptor proximal adaptor components MyD88 and MAVS, respectively

Go back
800.0, 1015.5
16.5, 16.5

p2

p2

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m6*0.1

nodelay

--

true

0

false

PMID: 18267068, 11983155 The exposed NLS of p50 coupled with nuclear export sequences (NES) in I¦ÊB¦Á and p65 leads to constant shuttling of I¦ÊB¦Á/NF-¦ÊB complexes between the nucleus and the cytoplasm, despite steady-state localization that appears almost exclusively cytosolic

Go back
835.0, 79.0
17.0, 17.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000289 MO000000206

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c59 : 1
stoichiometry:c58 : 1

m230*m177*0.1

nodelay

--

true

0

false

PMID: 18267068, 8565075 Following binding of TNF¦Á, TRAF2 is recruited to TNFR1 through its interaction with TRADD

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490.0, 850.0
19.0, 19.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e27 MO000016661

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c146 : 1
stoichiometry:c52 : 1

m27*m1637*0.1

nodelay

--

true

0

false

PMID: 18267068 It is important to bear in mind that although diverse upstream events may mediate IKK activation through a common mechanism, parallel signaling pathways emanating from nonredundant receptor proximal signaling components frequently produce crosstalk that shapes the NF-¦ÊB response in ways that are unique to individual signaling pathways. PMID: 18267068 The core elements of NF-¦ÊB signaling pathways are generally several steps removed from the receptor itself. The intervening steps between receptor and IKK form links to parallel signaling pathways.

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458.0, 818.0
19.0, 19.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e25 MO000016661

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c54 : 1
stoichiometry:c21 : 1

m25*m1637*0.1

nodelay

--

true

0

false

PMID: 18267068 It is important to bear in mind that although diverse upstream events may mediate IKK activation through a common mechanism, parallel signaling pathways emanating from nonredundant receptor proximal signaling components frequently produce crosstalk that shapes the NF-¦ÊB response in ways that are unique to individual signaling pathways. PMID: 18267068 The core elements of NF-¦ÊB signaling pathways are generally several steps removed from the receptor itself. The intervening steps between receptor and IKK form links to parallel signaling pathways.

Go back
886.0, 66.0
19.0, 19.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 MO000000207

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m29*m178*0.1

nodelay

--

true

0

false

PMID: 18267068, 8565075 Following binding of TNF¦Á, TRAF2 is recruited to TNFR1 through its interaction with TRADD

Go back
937.0, 53.0
21.0, 21.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000000209

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m30*m180*0.1

nodelay

--

true

0

false

PMID: 18267068, 8565075 Following binding of TNF¦Á, TRAF2 is recruited to TNFR1 through its interaction with TRADD

Go back
1042.0, 58.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000016965

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m30*m1874*0.1

nodelay

--

true

0

false

PMID: 18267068 TRAF5 was also shown to interact with the TNFR1 signaling complex,

Go back
615.0, 839.0
17.0, 17.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000016661

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c70 : 1
stoichiometry:c73 : 1

m32*m1637*0.1

nodelay

--

true

0

false

Go back
563.0, 838.5
18.5, 18.5

p27

p27

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 MO000016661

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c71 : 1
stoichiometry:c72 : 1

m31*m1637*0.1

nodelay

--

true

0

false

PMID: 18267068 TRAF2 and TRAF5 are together required for NF-¦ÊB activation by TNFR1.

Go back
274.0, 690.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e25 MO000000212

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c76 : 1

m25*m183*0.1

nodelay

--

true

0

false

PMID: 18267068, 17047224, 17072327 In Toll/IL-1 signaling TRAF6 is recruited to the receptor complex and is necessary for MyD88-dependent activation of NF-¦ÊB by IL-1 and ligands of TLR4

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245.0, 252.0
15.0, 15.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 18267068, 17047224, 17072327 In Toll/IL-1 signaling TRAF6 is recruited to the receptor complex and is necessary for MyD88-dependent activation of NF-¦ÊB by IL-1 and ligands of TLR4

Go back
858.0, 1002.0
19.0, 19.0

p3

p3

cso30:i:ME_NuclearExport

cso30:i:CC_Cytosol

--

e11

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 18267068, 11983155 The exposed NLS of p50 coupled with nuclear export sequences (NES) in I¦ÊB¦Á and p65 leads to constant shuttling of I¦ÊB¦Á/NF-¦ÊB complexes between the nucleus and the cytoplasm, despite steady-state localization that appears almost exclusively cytosolic

Go back
262.0, 298.0
19.0, 19.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000016573

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m34*m1572*0.1

nodelay

--

true

0

false

PMID: 18267068, 17047224, 17072327 In Toll/IL-1 signaling TRAF6 is recruited to the receptor complex and is necessary for MyD88-dependent activation of NF-¦ÊB by IL-1 and ligands of TLR4

Go back
253.0, 373.0
21.0, 21.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000000212

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m35*m183*0.1

nodelay

--

true

0

false

PMID: 18267068, 17047224, 17072327 In Toll/IL-1 signaling TRAF6 is recruited to the receptor complex and is necessary for MyD88-dependent activation of NF-¦ÊB by IL-1 and ligands of TLR4

Go back
1139.0, 67.0
17.0, 17.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m1872*m37*0.1

nodelay

--

true

0

false

PMID: 18267068, 15708970 TRAF3, which interacts with receptors that trigger the alternative pathway, also interacts with NIK and it now appears that theactivation of NIK is negatively regulated by TRAF3.

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1263.0, 295.0
17.0, 17.0

p33

p33

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000203 MO000017874

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m174*m2617*0.1

nodelay

--

true

0

false

PMID: 18267068, 17996648, 18022362, 18022363 In addition to TRAF3, cIAP1 and cIAP2 have been implicated as E3 ligases responsible for regulating constitutive NIK levels

Go back
1263.0, 62.5
18.5, 18.5

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e38 MO000000203

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m38*m174*0.1

nodelay

--

true

0

false

PMID: 18267068, 15708970 TRAF3, which interacts with receptors that trigger the alternative pathway, also interacts with NIK and it now appears that the activation of NIK is negatively regulated by TRAF3.

Go back
1218.0, 298.5
19.5, 19.5

p35

p35

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000203 MO000016963

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m174*m1872*0.1

nodelay

--

true

0

false

PMID: 18267068, 15084608 In the resting state, TRAF3 induces NIK ubiquitination and degradation, but upon stimulation TRAF3 undergoes signal-dependent degradation, mediated by other TRAF family members, resulting in the accumulation and activation of NIK and consequent activation of the noncanonical pathway

Go back
1153.0, 428.0
19.0, 19.0

p36

p36

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e41

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 18267068, 15084608 In the resting state, TRAF3 induces NIK ubiquitination and degradation, but upon stimulation TRAF3 undergoes signal-dependent degradation, mediated by other TRAF family members, resulting in the accumulation and activation of NIK and consequent activation of the noncanonical pathway

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1308.0, 48.0
23.0, 23.0

p37

p37

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 18267068, 15084608 In the resting state, TRAF3 induces NIK ubiquitination and degradation, but upon stimulation TRAF3 undergoes signal-dependent degradation, mediated by other TRAF family members, resulting in the accumulation and activation of NIK and consequent activation of the noncanonical pathway

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1375.0, 63.0
25.0, 25.0

p38

p38

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e42

MO000000203 e38 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18267068, 15084608 In the resting state, TRAF3 induces NIK ubiquitination and degradation, but upon stimulation TRAF3 undergoes signal-dependent degradation, mediated by other TRAF family members, resulting in the accumulation and activation of NIK and consequent activation of the noncanonical pathway

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778.0, 42.0
19.0, 19.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000065 e31

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m43*m31*0.1

nodelay

--

true

0

false

PMID: 18267068 RIP family members have been implicated in most TRAF-dependent pathways, e.g., signaling from TNFR superfamily and Toll/IL-1R. PMID: 18267068 RIP1 binds to NEMO and is essential for TNF¦Á-induced IKK and NF-¦ÊB activation

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1013.0, 745.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000193 e16

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c235 : 1
stoichiometry:c236 : 1

m166*m16*0.1

nodelay

--

true

0

false

PMID: 18267068, 17254973 In addition to I¦ÊB¦Á/¦Â/var epsilon, p100 can also act as a traditional I¦ÊB regulating p65-containing complexes downstream of IKK¦Á

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672.0, 56.0
23.0, 23.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000065 MO000016661

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c116 : 1
stoichiometry:c112 : 1

m43*m1637*0.1

nodelay

--

true

0

false

PMID: 18267068, 8565075, 9529147, 8947041, 10755617 RIP1 binds to NEMO and is essential for TNF¦Á-induced IKK and NF-¦ÊB activation

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562.0, 54.0
19.0, 19.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18267068, 8565075, 9529147, 8947041, 10755617 RIP1 binds to NEMO and is essential for TNF¦Á-induced IKK and NF-¦ÊB activation

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1000.0, 11.5
16.5, 16.5

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000016661

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c179 : 1
stoichiometry:c117 : 1

m31*m1637*0.1

nodelay

--

true

0

false

PMID: 18267068, 11359906 In the absence of RIP1, IKK recruitment occurs through TRAF2 but does not lead to IKK activation

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717.0, 33.0
21.0, 21.0

p43

p43

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e43

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18267068, 16603398, 16543241 RIP1 is inducibly ubiquitinated by TRAF2 following TNF¦Á stimulation. PMID: 18267068, 16547522 RIP also becomes rapidly ubiquitinated following TNF¦Á stimulation, and it has been proposed that it is through this posttranslational modification that RIP1 binds to NEMO.

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419.0, 319.5
17.5, 17.5

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 MO000041125

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c122 : 1
stoichiometry:c121 : 1

m34*m18998*0.1

nodelay

--

true

0

false

PMID: 18267068, 15064760, 16115877 In addition to TNFR1 signaling, and IKK activation via other death domain-containing TNFR family members, RIP1 has also been reported to be required for TRIF-dependent NF-¦ÊB activation via TLR3 and TLR4, as well as for NF-¦ÊB activation via RIG-I

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279.0, 103.0
17.0, 17.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e48 MO000000065

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m49*m43*0.1

nodelay

--

true

0

false

PMID: 18267068, 15064760, 16115877 In addition to TNFR1 signaling, and IKK activation via other death domain-containing TNFR family members, RIP1 has also been reported to be required for TRIF-dependent NF-¦ÊB activation via TLR3 and TLR4, as well as for NF-¦ÊB activation via RIG-I

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1583.0, 275.0
17.0, 17.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m119368*0.1

nodelay

--

true

0

false

PMID: 18267068, 15064760, 16115877 In addition to TNFR1 signaling, and IKK activation via other death domain-containing TNFR family members, RIP1 has also been reported to be required for TRIF-dependent NF-¦ÊB activation via TLR3 and TLR4, as well as for NF-¦ÊB activation via RIG-I

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1582.0, 362.0
19.0, 19.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e63 MO000041125

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m64*m18998*0.1

nodelay

--

true

0

false

PMID: 18267068, 15064760, 16115877 In addition to TNFR1 signaling, and IKK activation via other death domain-containing TNFR family members, RIP1 has also been reported to be required for TRIF-dependent NF-¦ÊB activation via TLR3 and TLR4, as well as for NF-¦ÊB activation via RIG-I

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1587.0, 499.0
17.0, 17.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e64 MO000000065

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m65*m43*0.1

nodelay

--

true

0

false

PMID: 18267068, 15064760, 16115877 In addition to TNFR1 signaling, and IKK activation via other death domain-containing TNFR family members, RIP1 has also been reported to be required for TRIF-dependent NF-¦ÊB activation via TLR3 and TLR4, as well as for NF-¦ÊB activation via RIG-I

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1140.5, 1012.5
14.5, 14.5

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e65

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c136 : 1
stoichiometry:c135 : 1

m68*m66*0.1

nodelay

--

true

0

false

PMID: 18267068, 15064760, 16115877 In addition to TNFR1 signaling, and IKK activation via other death domain-containing TNFR family members, RIP1 has also been reported to be required for TRIF-dependent NF-¦ÊB activation via TLR3 and TLR4, as well as for NF-¦ÊB activation via RIG-I

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885.0, 893.0
21.0, 21.0

p5

p5

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000000196

MO000016637

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m168*0.1

nodelay

--

true

0

false

PMID: 18267068 Constitutive binding of p50 or p52 homodimers to ¦ÊB sites on NF-¦ÊB-responsive promoters may thus act to check NF-¦ÊB transactivation until displaced by transcriptionally competent NF-¦ÊB dimers.

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1079.0, 1027.0
17.0, 17.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e49

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m68*m63*0.1

nodelay

--

true

0

false

PMID: 18267068, 15064760, 16115877 In addition to TNFR1 signaling, and IKK activation via other death domain-containing TNFR family members, RIP1 has also been reported to be required for TRIF-dependent NF-¦ÊB activation via TLR3 and TLR4, as well as for NF-¦ÊB activation via RIG-I

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606.0, 394.0
19.0, 19.0

p51

p51

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

MO000016599

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m1593*0.1

nodelay

--

true

0

false

PMID: 18267068, 15107419, 12612076, 17924664 NEMO can form tetramers in vitro and also is reported to oligomerize in vivo, although the stoichiometry of endogenous NEMO is debatable

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699.0, 971.0
17.0, 17.0

p52

p52

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000211 e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m182*m109*0.1

nodelay

--

true

0

false

PMID: 18267068 both IKK¦Á and IKK¦Â phosphorylate I¦ÊB¦Á at Ser32 and Ser36 and I¦ÊB¦Â at Ser19 and Ser23 PMID: 18267068, 9721103 I¦ÊB¦Á bound to NF-¦ÊB is thought to be a preferred substrate to free I¦ÊB¦Á PMID: 18267068 both IKK¦Á and IKK¦Â prefer I¦ÊB¦Á to I¦ÊB¦Â, which is consistent with the difference in I¦ÊB¦Á and ¦Â degradation

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553.0, 789.0
21.0, 21.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016661 e83

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c194 : 1
stoichiometry:c55 : 1

m1637*m85*0.1

nodelay

--

true

0

false

PMID: 18267068 Both BCL10 and CARD11 (CARMA1) are CARD-containing proteins that are crucial for IKK activation downstream of either the T cell or B cell antigen receptors. PMID: 18267068, 17098202 The most notable feature of the BCL10, CARD11, MALT1 (CBM) complex is its induced oligomerization following signaling, which is thought to be a key event in IKK activation downstream of these CARD-containing adaptor proteins

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1315.0, 1191.0
17.0, 17.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000017949

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m74*m2684*0.1

nodelay

--

true

0

false

PMID: 18267068 Members of the NOD-LRR family of intracellular pattern recognition receptors are CARD-containing proteins that can activate IKK¦Â via RIP2.

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1262.0, 1042.0
19.0, 19.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e73 MO000016661

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c111 : 1
stoichiometry:c154 : 1

m75*m1637*0.1

nodelay

--

true

0

false

PMID: 18267068, 10880512 RIP2 binds to NEMO and is believed to directly mediate activation of the IKK complex by proximity-induced mechanisms

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1001.0, 469.0
21.0, 21.0

p57

p57

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39 MO000000203

MO000038331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c90 : 1
stoichiometry:c22 : 1

m39*m174*0.1

nodelay

--

true

0

false

PMID: 18267068, 17047224 NIK directly phosphorylates and activates IKK¦Á. PMID: 18267068, 17047224, 17072322 The alternative pathway relies on the activation of IKK¦Á by the NF-¦ÊB-inducing kinase (NIK). PMID: 18267068 Active IKK¦Â is phosphorylated on two serines, Ser177 and Ser181, within the activation loop of the kinase domain, and IKK¦Á is similarly phosphorylated on activation loop serine residues 176 and 180.

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1162.0, 302.0
19.0, 19.0

p58

p58

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000203 MO000017875

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c162 : 1
stoichiometry:c161 : 1

m174*m2618*0.1

nodelay

--

true

0

false

PMID: 18267068, 17996648, 18022362, 18022363 In addition to TRAF3, cIAP1 and cIAP2 have been implicated as E3 ligases responsible for regulating constitutive NIK levels

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854.0, 423.5
17.5, 17.5

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 MO000000211

MO000033291

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c165 : 1
stoichiometry:c164 : 1

m39*m182*0.1

nodelay

--

true

0

false

PMID: 18267068, 10823818 It appears that IKK¦Á and IKK¦Â preferentially form heterodimers in vivo, and in vitro studies indicate that IKK¦Á/IKK¦Â heterodimers have higher catalytic efficiency than either homodimer

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886.0, 1238.0
19.0, 19.0

p6

p6

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

MO000016637 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m1622*m12*0.1

nodelay

--

true

0

false

PMID: 18267068 Constitutive binding of p50 or p52 homodimers to ¦ÊB sites on NF-¦ÊB-responsive promoters may thus act to check NF-¦ÊB transactivation until displaced by transcriptionally competent NF-¦ÊB dimers.

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1070.0, 422.0
19.0, 19.0

p60

p60

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e39

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 18267068, 9346484, 9346485, 9346241 IKK¦Á and IKK¦Â dimerize through the leucine zipper domain, which is also required for kinase activity.

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874.0, 354.0
19.0, 19.0

p61

p61

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000000211

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1

m182*0.1

nodelay

--

true

0

false

PMID: 18267068, 9346484, 9346485, 9346241 IKK¦Á and IKK¦Â dimerize through the leucine zipper domain, which is also required for kinase activity.

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801.0, 541.0
21.0, 21.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000211 MO000016599

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m182*m1593*0.1

nodelay

--

true

0

false

PMID: 18267068, 12244103, 10968790 IKK¦Á and IKK¦Â bind NEMO through the C-terminal hexapeptide NEMO-binding domain (NBD) (Leu-Asp-Trp-Ser-Trp-Leu) PMID: 18267068, 12244103 Competition experiments and biophysical analyses using the NBD peptide indicate that IKK¦Â binds to NEMO with considerably higher affinity than IKK¦Á

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893.0, 445.0
21.0, 21.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 MO000016599

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m39*m1593*0.1

nodelay

--

true

0

false

PMID: 18267068, 12244103, 10968790 IKK¦Á and IKK¦Â bind NEMO through the C-terminal hexapeptide NEMO-binding domain (NBD) (Leu-Asp-Trp-Ser-Trp-Leu) PMID: 18267068, 12244103 Competition experiments and biophysical analyses using the NBD peptide indicate that IKK¦Â binds to NEMO with considerably higher affinity than IKK¦Á

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623.0, 491.0
17.0, 17.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e71 MO000033291

MO000016661

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m73*m11981*0.1

nodelay

--

true

0

false

PMID: 18267068 Multiple lines of evidence point toward an IKK kinase complex that is composed of only IKK¦Á, IKK¦Â, and NEMO. PMID: 18267068, 17924664 Recombinant NEMO and IKK¦Â appear to associate in a 2:2 molar ratio and the minimum interaction domains form a dimer of dimers (tetramer) that can further assemble into octamers and dodecamers

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587.0, 587.0
17.0, 17.0

p65

p65

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016661 MO000021135 MO000021134

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c147 : 1
stoichiometry:c185 : 1
stoichiometry:c186 : 1
stoichiometry:c180 : 1

m1637*m5516*m5515*0.1

nodelay

--

true

0

false

PMID: 18267068 The first is the kinase chaperone HSP-90/Cdc37 that has been reported to constitutively associate with the IKK complex.

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490.0, 698.0
19.0, 19.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016661 e80 MO000000289

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1
stoichiometry:c182 : 1

m1637*m230*0.1

nodelay

--

true

0

false

PMID: 18267068, 11864612 The HSP-90 inhibitor geldanamycin has also been shown to inhibit activation of IKK by TNF-¦Á

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706.0, 666.0
19.0, 19.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016661 MO000065270

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1
stoichiometry:c189 : 1

m1637*m40137*0.1

nodelay

--

true

0

false

PMID: 18267068, 15218148 The second interacting protein that requires mentioning is ELKS, which has been proposed to be a regulatory component of the IKK complex in addition to NEMO

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737.0, 353.0
21.0, 21.0

p68

p68

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000211

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1

m182*0.1

nodelay

--

true

0

false

PMID: 18267068 Active IKK¦Â is phosphorylated on two serines, Ser177 and Ser181, within the activation loop of the kinase domain, and IKK¦Á is similarly phosphorylated on activation loop serine residues 176 and 180.

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1417.0, 777.0
21.0, 21.0

p69

p69

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e70 e68 e69

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c193 : 1

m72*m70*m71*0.1

nodelay

--

true

0

false

PMID: 18267068 Both BCL10 and CARD11 (CARMA1) are CARD-containing proteins that are crucial for IKK activation downstream of either the T cell or B cell antigen receptors. PMID: 18267068, 17098202 The most notable feature of the BCL10, CARD11, MALT1 (CBM) complex is its induced oligomerization following signaling, which is thought to be a key event in IKK activation downstream of these CARD-containing adaptor proteins PMID: 18267068, 17098202 In AgR signaling the CBM complex also assembles into a higher-order oligomer following signaling.

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1013.0, 885.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000196 e90

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m168*m92*0.1

nodelay

--

true

0

false

PMID: 18267068, 17072328, 16470223 Because p100 undergoes constitutive processing in certain tissues, RelB/p52 heterodimers may exhibit constitutive activation and RelB-deficient mice have decreased baseline NF-¦ÊB activity in the thymus and spleen

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730.0, 1022.0
19.0, 19.0

p70

p70

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e39 e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c145 : 1
stoichiometry:c148 : 1

m39*m109*0.1

nodelay

--

true

0

false

PMID: 18267068 both IKK¦Á and IKK¦Â phosphorylate I¦ÊB¦Á at Ser32 and Ser36 and I¦ÊB¦Â at Ser19 and Ser23 PMID: 18267068, 9721103 I¦ÊB¦Á bound to NF-¦ÊB is thought to be a preferred substrate to free I¦ÊB¦Á PMID: 18267068 both IKK¦Á and IKK¦Â prefer I¦ÊB¦Á to I¦ÊB¦Â, which is consistent with the difference in I¦ÊB¦Á and ¦Â degradation

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1185.0, 481.0
21.0, 21.0

p71

p71

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000234 MO000000211

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c202 : 1
stoichiometry:c199 : 1

m200*m182*0.1

nodelay

--

true

0

false

PMID: 18267068 both IKK¦Á and IKK¦Â phosphorylate I¦ÊB¦Á at Ser32 and Ser36 and I¦ÊB¦Â at Ser19 and Ser23 PMID: 18267068 both IKK¦Á and IKK¦Â prefer I¦ÊB¦Á to I¦ÊB¦Â, which is consistent with the difference in I¦ÊB¦Á and ¦Â degradation

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1240.0, 472.0
15.0, 15.0

p72

p72

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000234 e39

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c200 : 1
stoichiometry:c203 : 1
stoichiometry:c201 : 1

m200*m39*0.1

nodelay

--

true

0

false

PMID: 18267068 both IKK¦Á and IKK¦Â phosphorylate I¦ÊB¦Á at Ser32 and Ser36 and I¦ÊB¦Â at Ser19 and Ser23 PMID: 18267068 both IKK¦Á and IKK¦Â prefer I¦ÊB¦Á to I¦ÊB¦Â, which is consistent with the difference in I¦ÊB¦Á and ¦Â degradation

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735.0, 1215.5
17.5, 17.5

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c204 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18267068 The nuclear NF-¦ÊB drives I¦ÊB¦Á expression generating a negative feedback loop.

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836.0, 1372.0
23.0, 23.0

p74

p74

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18267068 Like I¦ÊB¦Á, I¦ÊBvar epsilon is degraded in an IKK-dependent manner and its expression is upregulated by NF-¦ÊB.

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690.0, 1390.0
19.0, 19.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e22 e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1
stoichiometry:c210 : 1

m22*m89*0.1

nodelay

--

true

0

false

PMID: 18267068, 8816457, 7867065 I¦ÊB¦Â is capable of associating with NF-¦ÊB dimers that are bound to DNA.

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1131.0, 803.0
17.0, 17.0

p76

p76

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000199 MO000000211

MO000081711

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c213 : 1
stoichiometry:c212 : 1

m171*m182*0.1

nodelay

--

true

0

false

PMID: 18267068, 17072324, 15371334 Multiple reports have demonstrated that IKK¦Â-dependent phosphorylation of the C-terminal region of p105 at Ser923 and Ser927 (Ser933 in human p105) leads to complete degradation of the protein analogous to I¦ÊB¦Á

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1177.0, 917.0
21.0, 21.0

p77

p77

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000081711 MO000000291

MO000019479 MO000000200

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c215 : 1

m55989*m232*0.1

nodelay

--

true

0

false

PMID: 18267068, 16619030 Normal processing of p105 to p50 in an E1 Ub-activating enzyme-deficient cell line, complemented by in vitro analysis, strongly suggests that p105 processing can occur via the 20S proteasome, independent of ubiquitination, and in a manner that is inconsistent with cotranslational processing

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1247.0, 743.0
17.0, 17.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000199 MO000000058

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c218 : 1
stoichiometry:c220 : 1
stoichiometry:c219 : 1

m171*m68*0.1

nodelay

--

true

0

false

PMID: 18267068 Thus unprocessed p105 acts as an I¦ÊB protein that binds NF-¦ÊB dimers and can be inducibly degraded upon IKK activation.

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1244.0, 812.0
23.0, 23.0

p79

p79

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e89

e67 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c221 : 1
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m91*0.1

nodelay

--

true

0

false

PMID: 18267068 Thus unprocessed p105 acts as an I¦ÊB protein that binds NF-¦ÊB dimers and can be inducibly degraded upon IKK activation.

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930.0, 1158.0
19.0, 19.0

p8

p8

cso30:i:ME_Transcription

cso30:i:CC_Cytosol

--

e14

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18267068, 16732290 Likewise it has been shown that in T cells p100 also limits p65-mediated NF-¦ÊB activity in a negative feedback loop set up following T cell activation

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1127.0, 519.0
17.0, 17.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m16*m92*0.1

nodelay

--

true

0

false

PMID: 18267068, 11687592 Regulation of RelB by p100 is especially crucial because RelB-containing dimers only associate with p100, and it has been suggested that they require p100 binding for stabilization

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1022.0, 618.0
19.0, 19.0

p81

p81

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000202 MO000018837

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c228 : 1
stoichiometry:c229 : 1

m173*m3459*0.1

nodelay

--

true

0

false

PMID: 18267068, 16303288, 12185077, 14676825 Phosphorylation of p100 at serines 866, 870, and 872 (Ser865, 869, and 871 in human p100) leads to the recruitment of SCF¦ÂTrCP, polyubiquitination of Lys855 in a region with sequence homology to Lys22 of I¦ÊB¦Á, and subsequent degradation or processing to p52

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1165.0, 617.0
21.0, 21.0

p82

p82

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e92

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c230 : 1
stoichiometry:c231 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 18267068, 16303288, 12185077, 14676825 Phosphorylation of p100 at serines 866, 870, and 872 (Ser865, 869, and 871 in human p100) leads to the recruitment of SCF¦ÂTrCP, polyubiquitination of Lys855 in a region with sequence homology to Lys22 of I¦ÊB¦Á, and subsequent degradation or processing to p52

Go back
1244.0, 668.0
23.0, 23.0

p83

p83

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e93

MO000000196 MO000018837 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c232 : 1
stoichiometry:c233 : 1
stoichiometry:c234 : 1

m95*0.1

nodelay

--

true

0

false

PMID: 18267068 The noncanonical or alternative NF-¦ÊB pathway, however, proceeds through proteasomal processing, rather than degradation, of p100 to p52, thereby liberating p52 containing NF-¦ÊB dimers that drive a transcriptional response that is distinct from that induced by the canonical, I¦ÊB¦Á-regulated pathway. PMID: 18267068, 16303288, 12185077, 14676825 Phosphorylation of p100 at serines 866, 870, and 872 (Ser865, 869, and 871 in human p100) leads to the recruitment of SCF¦ÂTrCP, polyubiquitination of Lys855 in a region with sequence homology to Lys22 of I¦ÊB¦Á, and subsequent degradation or processing to p52

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950.0, 1174.0
19.0, 19.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000000238 MO000016637

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c237 : 1
stoichiometry:c238 : 1
stoichiometry:c239 : 1

m204*m1622*0.1

nodelay

--

true

0

false

PMID: 18267068 Bcl-3 is found in the nucleus associated with p50- and p52-containing homo- and heterodimers.

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982.0, 1226.0
19.0, 19.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e20 MO000000238

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m20*m204*0.1

nodelay

--

true

0

false

PMID: 18267068 Bcl-3 is found in the nucleus associated with p50- and p52-containing homo- and heterodimers.

Go back
1113.0, 1293.0
21.0, 21.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016636 MO000000238

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1
stoichiometry:c245 : 1

m1621*m204*0.1

nodelay

--

true

0

false

PMID: 18267068 Bcl-3 is found in the nucleus associated with p50- and p52-containing homo- and heterodimers. PMID: 18267068, 17673665 Bcl-3 may also stabilize repressive p50 homodimers and inhibit NF-¦ÊB activation by preventing the access of TAD-containing dimers to ¦ÊB sites

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1030.0, 1293.5
20.5, 20.5

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000238

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c246 : 1
stoichiometry:c247 : 1

m204*0.1

nodelay

--

true

0

false

PMID: 18267068, 12808109, 11713278 Cyclin D1 is a Bcl-3-regulated gene that is of particular interest owing to its role in cell proliferation and cancer.

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1063.0, 1283.0
17.0, 17.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000238

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c248 : 1

m204*0.1

nodelay

--

true

0

false

PMID: 18267068, 16384933 Bcl-3 has also recently been implicated in the regulation of p53 by enhancing the transcription of Hdm2 in normal and cancer cells

Go back
593.0, 1409.0
21.0, 21.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c251 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18267068, 15371334 I¦ÊB¦Æ is not expressed constitutively but rather is upregulated in response to IL-1 and TLR4 ligands, but not TNF, and upon expression localizes to the nucleus

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634.0, 946.0
19.0, 19.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e79 e106

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c153 : 1
stoichiometry:c271 : 1
stoichiometry:c2 : 1

m81*m109*0.1

nodelay

--

true

0

false

PMID: 18267068 Degradation of I¦ÊB is a rapidly induced signaling event that is initiated upon specific phosphorylation of these molecules by activated IKK.

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641.0, 1425.0
21.0, 21.0

p90

p90

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c250 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18267068, 15371334 I¦ÊB¦Æ is not expressed constitutively but rather is upregulated in response to IL-1 and TLR4 ligands, but not TNF, and upon expression localizes to the nucleus

Go back
494.0, 1413.5
20.5, 20.5

p91

p91

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e100 e23

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c258 : 1
stoichiometry:c254 : 1

m102*m23*0.1

nodelay

--

true

0

false

PMID: 18267068, 15371334 I¦ÊB¦Æ is not expressed constitutively but rather is upregulated in response to IL-1 and TLR4 ligands, but not TNF, and upon expression localizes to the nucleus

Go back
458.0, 1498.0
19.0, 19.0

p92

p92

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e100 e34

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c259 : 1
stoichiometry:c256 : 1

m102*m34*0.1

nodelay

--

true

0

false

PMID: 18267068, 15371334 I¦ÊB¦Æ is not expressed constitutively but rather is upregulated in response to IL-1 and TLR4 ligands, but not TNF, and upon expression localizes to the nucleus

Go back
603.0, 1666.5
18.5, 18.5

p93

p93

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e101

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 18267068, 15371334 I¦ÊB¦Æ is not expressed constitutively but rather is upregulated in response to IL-1 and TLR4 ligands, but not TNF, and upon expression localizes to the nucleus

Go back
671.0, 1523.0
17.0, 17.0

p94

p94

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e102 MO000016636

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c263 : 1
stoichiometry:c264 : 1

m104*m1621*0.1

nodelay

--

true

0

false

PMID: 18267068 I¦ÊB¦Æ is inducibly expressed following NF-¦ÊB activation and once expressed associates primarily with p50 homodimers.

Go back
894.0, 1418.0
19.0, 19.0

p95

p95

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e104 MO000016636 e102

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c265 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1
stoichiometry:c266 : 1

m106*m1621*m104*0.1

nodelay

--

true

0

false

PMID: 18267068, 15241416 I¦ÊB¦Æ is found associated with p50 on the promoter of IL-6, which is not inducibly expressed in I¦ÊB¦Æ knockout cells, and it is, therefore, hypothesized that I¦ÊB¦Æ acts as a coactivator for p50 homodimers

Go back
573.0, 1297.0
21.0, 21.0

p96

p96

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e17

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18267068, 9660950 PKA exists in a complex with cytosolic NF-¦ÊB:I¦ÊB complexes and following degradation of I¦ÊB¦Á phosphorylates p65 at Ser276, promoting the interaction of p65 with the transcriptional coactivators CBP (CREB-binding protein) and p300

Go back
1162.0, 1466.0
19.0, 19.0

p97

p97

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e20 MO000019013

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c273 : 1
stoichiometry:c275 : 1
stoichiometry:c274 : 1

m20*m3621*0.1

nodelay

--

true

0

false

PMID: 18267068 In addition to PKA, other kinases, most notably MSK1 and MSK2 (mitogen- and stress-activated protein kinase), have been reported to phosphorylate Ser276 of p65.

Go back
1110.0, 1466.0
19.0, 19.0

p98

p98

cso30:i:ME_Phosphorylation

cso30:i:CC_Nucleoplasm

--

e20 e109

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c276 : 1
stoichiometry:c278 : 1
stoichiometry:c277 : 1

m20*m112*0.1

nodelay

--

true

0

false

PMID: 18267068 In addition to PKA, other kinases, most notably MSK1 and MSK2 (mitogen- and stress-activated protein kinase), have been reported to phosphorylate Ser276 of p65.

Go back
492.0, 1269.5
21.5, 21.5

p99

p99

cso30:i:ME_Phosphorylation

cso30:i:CC_Extracellular

--

e17 e19 MO000000211

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c280 : 1
stoichiometry:c281 : 1

m17*m19*m182*0.1

nodelay

--

true

0

false

PMID: 18267068, 15122352, 17072324 IKK¦Á and IKK¦Â have been implicated in the direct phosphorylation of p65 at Ser536

Go back
635.0, 888.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 848.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.5597439159879, 447.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1281.0, 78.15541752799933

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1320.0, 71.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1331.0, 94.25728398044637

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1220.281058856333, 86.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1221.336560450026, 82.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
494.1808490232225, 88.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.2878904937786, 59.29949271111367

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.0365441543581, 61.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 69.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 914.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.5099485156278, 85.60759898801275

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 610.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.1159660434203, 79.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.3460102252582, 79.71656125721721

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
572.0, 73.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1008.0, 36.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
684.0, 87.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.7106386350908, 19.502151416457835

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 62.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
450.91663099122354, 43.6673254373779

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 1195.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
360.0, 278.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
367.1898088913156, 189.33656045002587

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 345.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.4, 122.8

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.8197706407035, 115.6885458616194

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 115.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1525.925878648913, 289.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 226.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1519.0, 337.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 372.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.0, 1203.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1528.0843778027024, 377.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1521.0, 430.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.0, 225.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1518.474342794626, 511.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1116.0, 972.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1132.712767371256, 1027.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1158.7523442232734, 558.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1092.104939246337, 972.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1092.0, 1044.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
403.0, 170.0

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 1257.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1444.1031648045912, 730.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1436.5570731934433, 805.1656981722988

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.0887857024705, 412.70798021359997

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
541.9930645847388, 404.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.0, 417.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 909.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
511.5652529271701, 614.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 596.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 1032.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1324.0, 1216.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.7429413199791, 994.0

c15

c15

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1331.3018430168743, 1127.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1306.4160504432625, 1162.233989173968

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1276.1350326638506, 1068.709840175016

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 956.2161372907833

c153

c153

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1236.1143318680631, 1061.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.1841467190063, 321.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.1078544935208, 1167.8648038180315

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1012.0, 444.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1242.6656542647313, 312.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1283.6499055497527, 246.0

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
904.0, 841.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1177.4941633431786, 238.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1181.0, 321.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1089.0, 298.0

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
880.0, 432.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 432.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.0, 380.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 432.0

c166

c166

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0, 441.0

c167

c167

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 364.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 364.0

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1035.181663749449, 611.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 380.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.0, 496.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 562.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.811627803576, 435.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 459.6620417909756

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
878.6281649995302, 466.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.4426950711489, 441.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 508.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
711.3216862255927, 380.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
694.0, 34.97463535640725

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 906.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
577.9441005758471, 604.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.8251798420246, 607.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
471.02265177634234, 717.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 720.2253129537078

c183

c183

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
508.6796166259577, 59.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.0, 516.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 519.0

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
691.0, 614.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.467394304649, 690.840171189057

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
725.0, 676.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.6752787613661, 909.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
766.0, 364.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.8862537282752, 348.3442477945924

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1428.0, 741.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1428.0, 798.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.981087470575, 801.5497661203009

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 1054.0

c195

c195

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.0, 1230.7344341665032

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.3028234973079, 444.0

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1202.4323213903456, 434.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1204.0, 502.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
648.0, 965.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.7005280535601, 988.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1226.0, 434.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1237.0183750985082, 487.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 369.0

c202

c202

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1024.0, 434.0

c203

c203

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.3000604264644, 1233.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.2694147517064, 1231.3400013724056

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.949446294789, 1385.8979440997437

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
859.0, 1359.2573723617468

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 1400.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.0, 1390.0

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 837.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
700.0, 1409.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1150.4757828400086, 763.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1145.0, 820.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.0, 380.0

c213

c213

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1188.0, 895.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1198.0, 928.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1122.0, 882.0

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.65055317494995, 931.0

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1192.0, 752.0

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1264.0, 752.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.0514775921964, 490.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1117.0, 766.5309256348511

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1269.7053735814004, 768.0

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1136.2542245316151, 835.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
497.3955952472347, 829.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.0, 483.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.8223117743428, 540.4864091719768

c225

c225

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1144.0, 530.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.0, 628.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 643.4

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1041.0, 628.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.0, 493.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.0, 628.0

c230

c230

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1186.0, 628.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.3509217994431, 685.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
990.9605989328238, 681.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.86556099866846, 687.0

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
925.0, 493.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.6735746386122, 766.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 1184.0

c237

c237

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
907.0, 1184.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.0, 1187.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.0, 562.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.5861517711583, 1250.7266838911873

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1002.2625061574892, 1199.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 1245.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1139.2394443073426, 1278.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1037.0, 1199.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.0, 1304.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.0, 1199.0

c246

c246

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1040.0, 1314.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.0, 1300.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1031.0, 1199.0

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.1867236234419, 1142.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
632.6568542494924, 1446.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.0, 1430.0

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
361.0, 614.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
356.0, 288.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
504.0, 1434.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.348340448075, 1432.1625769017032

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.0, 1517.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.76502827703496, 1477.0

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
359.0, 614.0

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
354.0, 288.0

c259

c259

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.0, 1180.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.0, 1676.0

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 1553.0

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
628.0, 1532.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
694.9831658926657, 1272.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.0, 1540.0

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
830.0, 1428.0

c265

c265

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
904.0, 1437.0

c266

c266

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.7397467436193, 1273.0

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 1434.6655272802914

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.6568542494924, 812.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.0, 1038.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
696.0, 888.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.5039238887392, 897.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.0, 819.5222318968416

c272

c272

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1172.0, 1433.0

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 1485.0

c274

c274

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1084.0, 1442.0

c275

c275

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1134.4774036933125, 1433.0

c276

c276

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1127.0, 1485.0

c277

c277

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 1462.0

c278

c278

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
787.950454843015, 1324.9612090925891

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.5280520215392, 719.0

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
508.0537808947188, 1298.731881015412

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.55536140234807, 380.0

c281

c281

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
549.0471404825303, 1261.0

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.8121079572823, 1312.0

c283

c283

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.7848940638889, 444.0

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
475.7136431424303, 1247.0

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.0, 1283.0

c286

c286

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
430.0, 1290.9021037226325

c287

c287

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.6744378067606, 1261.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
478.0, 1372.0

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
569.8311367793272, 1189.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
423.0, 1253.0

c290

c290

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1135.848442145943, 1555.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.9220899170605, 1534.9726042969965

c292

c292

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1101.0, 1567.0

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.0, 1602.0

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1082.0, 1656.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.5559743736493, 1660.0

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1257.0, 1405.0

c297

c297

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1260.0, 1469.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1237.899624723816, 1461.0

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.0, 796.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.56202665840806, 1149.6106996796884

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1229.0, 1452.0

c300

c300

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1221.1570394041598, 1586.0

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.6568542494924, 1628.0

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
980.0, 1622.1508977964877

c303

c303

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 1633.0

c304

c304

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.0, 1671.0

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
707.9960966086966, 1656.0

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
957.0, 1525.0

c307

c307

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
950.1600228293936, 1535.9154498946862

c308

c308

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1071.0, 1583.0

c309

c309

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
566.0, 1261.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.8599434057003, 1670.0

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.0, 1700.0

c311

c311

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1117.0, 1472.3767971029347

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1189.598032634304, 1574.0

c313

c313

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
928.0, 1558.0

c314

c314

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
944.4452081011954, 1560.7391236038202

c315

c315

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.0, 1529.0

c316

c316

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.8783449553101, 1550.9789996974569

c317

c317

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
764.0, 1586.0

c318

c318

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 1542.0

c319

c319

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.2680368629482, 1318.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
767.8649682467477, 1585.7795818292902

c320

c320

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
775.0, 1581.6568542494924

c321

c321

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
823.9284852929829, 1570.0672960971324

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.0, 1549.0

c323

c323

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.0, 1534.0

c324

c324

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
775.0, 1621.0

c325

c325

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.9584313707192, 1589.0

c326

c326

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.0, 1702.0

c327

c327

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1226.6193931775947, 1382.4382058168303

c328

c328

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1175.0, 1354.0

c329

c329

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.0, 1219.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1208.0, 1387.0

c330

c330

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.0, 1668.0

c331

c331

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
971.8479626207359, 1721.0

c332

c332

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
963.0, 1378.0

c333

c333

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.2639240088533, 1432.8995250553337

c334

c334

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.9729804397589, 1393.0

c335

c335

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.8053473145734, 1355.7540106324884

c336

c336

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.7247306747782, 1400.0

c337

c337

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 1679.0

c338

c338

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 1253.725281140854

c339

c339

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.0, 1554.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.9334769998148, 1658.0

c340

c340

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1032.2829174186304, 1509.0

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.0, 1550.0

c342

c342

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
974.0, 1557.2157741863864

c343

c343

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.0, 158.0

c344

c344

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.6990699817187, 300.9693977915938

c345

c345

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.0, 284.0

c346

c346

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.0, 284.0

c347

c347

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.0, 284.0

c348

c348

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.0, 291.0

c349

c349

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 1409.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1056.0, 361.0

c350

c350

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
453.57784755536187, 157.5644154163661

c351

c351

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1063.9242033815156, 310.0

c352

c352

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1367.0, 490.0

c353

c353

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1376.0, 561.0

c354

c354

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1348.7186711919194, 634.0

c355

c355

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
743.4043756496454, 440.029062765764

c356

c356

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
541.5789279518963, 414.56122062695994

c357

c357

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1349.0, 689.0

c358

c358

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1600.0, 774.9464590424101

c359

c359

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.4524817084066, 1203.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1385.0, 266.0

c360

c360

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1608.0, 673.8410346492233

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1637.0, 666.0

c362

c362

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1696.7214202482928, 779.0

c363

c363

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1306.0, 1143.0

c364

c364

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1412.0, 1176.0

c365

c365

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.0, 675.0

c366

c366

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1373.0, 1006.0

c367

c367

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1182.488102949512, 1107.0

c368

c368

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1177.0, 1161.0

c369

c369

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
520.8063839788744, 1252.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0, 1325.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 530.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.1890065651294, 900.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.50674493453687, 516.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
284.0, 546.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.0, 596.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.0, 567.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
375.5326199862716, 602.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
445.0, 225.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
549.0, 225.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
520.9975603804354, 234.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
518.0, 259.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.0, 281.11773585424936

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.1720032412167, 1032.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 284.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
574.0578826022997, 614.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.4040480257699, 869.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.0957860907972, 351.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.4524082737194, 614.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
483.10831583892065, 810.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.0, 670.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
844.0, 59.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 96.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 102.93684433976615

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.0, 1028.6847882421503

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 92.21218445974618

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 93.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 85.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 81.88077416672961

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
951.2541403536056, 81.9010842277157

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.0, 74.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
943.0, 79.57434129350538

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1052.0, 85.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1056.0, 77.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.2445326056745, 168.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
851.2397421507617, 907.9033562111058

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.8669836198026, 614.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
579.2491077284276, 614.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
490.44625251151007, 857.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
492.48941102997907, 854.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.4353115232858, 168.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
299.6564023547028, 660.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.0, 702.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
300.8196623949279, 671.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
253.3632612873492, 208.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.4526209558805, 225.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1256.0, 643.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 261.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.3104923889621, 276.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.09822640966564, 323.8705560397336

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
281.0, 310.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
280.6262673050237, 331.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.076967675314, 400.88319217910157

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.0, 384.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1118.0, 91.76909137813423

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1151.539315685768, 91.85050999741726

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1154.0, 84.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
985.0, 756.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1024.7417856282407, 238.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
938.0, 552.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1214.0, 87.21795896565989

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1207.0, 88.23218423116838

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1272.0, 81.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1213.0, 238.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1205.0, 238.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1228.0, 318.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1126.0, 217.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.2850231591362, 378.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back