1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18272355.csml convertedTime:2009.07.01.11:16

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title MDA5/RIG-I and virus recognition.
Authors Takeuchi O, Akira S.
Affiliation Laboratory of Host Defense, WPI Immunology Frontier Research Center, OsakaUniversity, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract The innate immune system initially recognizes RNA virus infection and evokesantiviral responses by producing type I interferons (IFNs). Toll-like receptors(TLRs) and cytoplasmic retinoic acid-inducible gene I (RIG-I)-like helicases(RLHs) are the two major receptor systems for detecting RNA viruses. The RLHsignaling pathways play essential roles in the recognition of RNA viruses invarious cells, with the exception of plasmacytoid dendritic cells, which utilizeTLRs for virus recognition. The route of infection determines the cell typesresponsible for type I IFN production. Recent studies have suggested that TLRsare critical for activation of adaptive immune responses against several virusinfections, although it may be premature to draw such a conclusion for virusinfections in general. In this review, we will discuss recent advances towardclarifying the signaling pathways activated by RLHs and TLRs.
PMID 18272355
Model Abstract

Entity

MO000000058:NF-kappaB MO000000210:IKK-alpha MO000000213:IRAK MO000007694:IRF-3 MO000007702:IRF-7{p} MO000013119:STAT1 MO000016573:MyD88 MO000016608:IKK-i MO000016660:IFNbeta MO000016899:FADD MO000016900:Caspase-8 MO000016906:Caspase-10 MO000016963:TRAF3 MO000019326:TANK MO000019331:TBK1 MO000019398:TLR3 MO000022224:dsRNA MO000039077:IRAK-4 MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000066987:DDX58 MO000070429:ATG5:ATG12 MO000090351:Efp MO000094908:MAVS MO000103999:IFIH1 MO000107907:RNF125 e1: e10: e11:ssRNA:DDX58{ub}:MAVS:TRAF3{ub} e12:PolyI:C:IFIH1:MAVS:TRAF3{ub} e13:DDX58:ATG5:ATG12 e14:MAVS:ATG5:ATG12 e15:PolyI:C e16:ssRNA:DDX58{ub} e17:ssRNA:DDX58{ub}:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD e18:NAP1 e19:SINTBAD e2: e20:PolyI:C:IFIH1:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD e21:ssRNA:DDX58{ub}:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD:TBK1:IKK-i e22:degradants e23:PolyI:C:IFIH1:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD:TBK1:IKK-i e24:IRF-3{p} e25:IRF-7 e26:IRF-3{p}:IRF-3{p} e27:IRF-7{p}:IRF-7{p} e28:IRF-3{p}:IRF-7{p} e29:IRF-3{p}:IRF-7{p} e3: e30:IRF-7{p}:IRF-7{p} e31:IRF-3{p}:IRF-3{p} e32:ISREs e33:IRF-7{p}:IRF-7{p}:ISRE e34:IRF-3{p}:IRF-7{p}:ISRE e35:IRF-3{p}:IRF-3{p}:ISRE e36:Type I IFNs e37:IFN inducible genes e38:FADD:Caspase-8 e39:FADD:Caspase-10 e4: e40:FADD:MAVS e41:NF-kappaB{active} e42:IFNbeta receptor e43:IFNbeta:IFNbeta receptor e44:IKK-i{active} e45:STAT1{p} e46: e47: e48: e49:ssRNA e5:LGP2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:DDX58:LGP2 e60: e61: e62: e63:TLR7:ssRNA e64:TLR8:ssRNA e65:CpG DNA e66:TLR9:CpGDNA e67:CpGDNA:TLR9:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7 e68:CpGDNA:TLR9:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7{p} e69:ssRNA:TLR7:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7 e7: e70:ssRNA:TLR7:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7{p} e71:IRF-7 e72:RLHs e73:dsRNA:RLHs e75:ssRNA e76:ssRNA:DDX58 e77:ssRNA:DDX58{ub}:MAVS e78:PolyI:C:IFIH1 e79:PolyI:C:IFIH1:MAVS e8: e80:TRAF3{ub} e81:DUBA e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p6 p7 p8 p9
Model Detail
250.0, 542.0
20.0, 20.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
528.0, 284.0
24.0, 24.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42 p43

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
674.0, 222.0
20.0, 20.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42 p43

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
253.0, 1133.0
22.0, 22.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
456.0, 1140.0
24.0, 24.0

IRF-7{p}

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p15

p17 p18

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
605.0, 377.0
22.0, 22.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
730.0, 210.0
20.0, 20.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42 p43

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
249.0, 741.0
22.0, 22.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11 p36

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
573.0, 45.0
22.0, 22.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
361.0, 409.0
22.0, 22.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p32 p33

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
276.0, 412.0
23.0, 23.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
469.0, 345.0
22.0, 22.0

Caspase-10

--

MO000016906

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m1821

10

false

infinite

0

unit false false false
TRANSPATHMO000016906

--

Go back
473.0, 629.0
22.0, 22.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
641.0, 857.0
21.0, 21.0

TANK

--

MO000019326

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p9

true true true true

csml-variable:Double

m3897

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000019326

--

Go back
308.0, 700.0
23.0, 23.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p11

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
923.0, 327.0
17.0, 17.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1086.0, 334.0
20.0, 20.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38 p49

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
594.0, 238.0
20.0, 20.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42 p43

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
918.0, 354.0
20.0, 20.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
895.0, 467.0
18.0, 18.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
879.0, 251.0
18.0, 18.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
923.0, 399.0
18.0, 18.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
569.0, 501.0
21.0, 21.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p4 p50

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
857.0, 601.0
22.0, 22.0

ATG5:ATG12

--

MO000070429

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p5

true true true true

csml-variable:Double

m45270

10

false

infinite

0

unit false false false
TRANSPATHMO000070429

--

Go back
773.0, 717.0
21.0, 21.0

Efp

--

MO000090351

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m63891

10

false

infinite

0

unit false false false
TRANSPATHMO000090351

--

Go back
567.0, 679.0
26.5, 26.5

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p3 p5 p33

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
895.0, 711.0
18.0, 18.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
388.0, 612.0
16.0, 16.0

RNF125

--

MO000107907

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m80707

10

false

infinite

0

unit false false false
TRANSPATHMO000107907

--

Go back
170.2251538736242, 135.5171605507697
907.3661389946499, 1317.49563382023

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
175.90787743635653, 149.47541322869063
879.5156482254278, 1237.2312108238748

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
527.0, 781.0
18.176470588235293, 30.29411764705883

ssRNA:DDX58{ub}:MAVS:TRAF3{ub}

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p9

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
663.0, 805.0
18.176470588235293, 30.294117647058822

PolyI:C:IFIH1:MAVS:TRAF3{ub}

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

p6

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
852.5, 636.0
22.63240961644339, 31.580106441548917

DDX58:ATG5:ATG12

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
452.5, 504.0
22.63240961644339, 31.580106441548917

MAVS:ATG5:ATG12

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
814.0, 786.0
20.0, 20.0

PolyI:C

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
669.5, 555.0
20.993001166472247, 25.70571571404764

ssRNA:DDX58{ub}

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52 p53

p2 p54

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
367.0, 687.0
25.411764705882355, 42.35294117647059

ssRNA:DDX58{ub}:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
497.0, 934.5
29.655866371503315, 18.28778426242705

NAP1

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6 p9

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
560.0, 922.5
24.159999999999997, 18.12

SINTBAD

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p6 p9

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
170.2251538736242, 135.5171605507697
907.3661389946499, 1317.49563382023

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
433.0, 849.0
22.5, 37.5

PolyI:C:IFIH1:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p11

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
307.0, 891.0
25.411764705882355, 42.35294117647059

ssRNA:DDX58{ub}:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD:TBK1:IKK-i

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

p12 p14

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
428.0, 664.0
16.094198736358425, 15.557725445146472

degradants

--

e22

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
385.0, 1001.0
22.5, 37.5

PolyI:C:IFIH1:MAVS:TRAF3{ub}:TANK:NAP1:SINTBAD:TBK1:IKK-i

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p13 p15

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
353.0, 1189.0
22.0, 22.0

IRF-3{p}

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12 p13

p16 p18

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
540.0, 1088.0
24.0, 24.0

IRF-7

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15 p42 p43

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
354.5, 1325.0
18.68221963006165, 22.876187302116307

IRF-3{p}:IRF-3{p}

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p21

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
457.5, 1284.0
20.111148141976326, 24.625895684052658

IRF-7{p}:IRF-7{p}

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p20

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
557.5, 1260.0
20.111148141976326, 24.625895684052658

IRF-3{p}:IRF-7{p}

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
699.5, 1197.0
17.171638060323268, 21.02649558406932

IRF-3{p}:IRF-7{p}

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p23

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
188.3724766535172, 153.66448333066268
871.0714934348641, 1281.200988260445

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
658.5, 1132.0
19.22112981169804, 23.53607732044659

IRF-7{p}:IRF-7{p}

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p22

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
818.5, 1221.0
18.68221963006165, 22.876187302116307

IRF-3{p}:IRF-3{p}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p24

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
709.0, 1082.5
53.23427964977448, 11.534093924117803

ISREs

--

e32

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p22 p23 p24

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
708.0, 1029.5
48.027770635124725, 13.60786834661867

IRF-7{p}:IRF-7{p}:ISRE

--

e33

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p22

p25 p26

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
796.0, 1129.5
48.027770635124725, 13.60786834661867

IRF-3{p}:IRF-7{p}:ISRE

--

e34

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p23

p27 p28

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
848.0, 1177.5
48.027770635124725, 13.60786834661867

IRF-3{p}:IRF-3{p}:ISRE

--

e35

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p24

p29 p30

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
813.0, 950.0
37.993079584775096, 20.26297577854671

Type I IFNs

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p25 p27 p29

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
891.0, 1021.0
41.211072664359875, 21.97923875432526

IFN inducible genes

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p26 p28 p30 p48

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
321.5, 291.0
20.911348108648557, 25.60573237793701

FADD:Caspase-8

--

e38

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
433.5, 287.0
20.911348108648557, 25.60573237793701

FADD:Caspase-10

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
221.94502379631933, 185.4222981954752
803.9263991492595, 1217.6853585308186

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
270.5, 465.0
18.21679720046659, 22.306282286285622

FADD:MAVS

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
302.0, 598.0
20.0, 20.0

NF-kappaB{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p34

--

true true true true

csml-variable:Double

m42

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
565.5, 148.0
21.384885764499124, 32.89982425307557

IFNbeta receptor

--

e42

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
689.5, 136.0
20.634948476211356, 39.93860995395747

IFNbeta:IFNbeta receptor

--

e43

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

p36

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
657.0, 341.0
22.0, 22.0

IKK-i{active}

--

e44

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p37

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
705.0, 441.0
22.0, 22.0

STAT1{p}

--

e45

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

--

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
786.0, 230.0
185.22014677716015, 309.2234653822081

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false true false

--

Go back
786.0, 230.0
185.22014677716015, 309.2234653822081

--

e47

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false true false

--

Go back
786.0, 230.0
185.22014677716015, 309.2234653822081

--

e48

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false true false

--

Go back
1089.0, 398.5
38.16268362201272, 19.717386538039904

ssRNA

--

e49

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p39 p40

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
621.0, 435.5
22.880000000000006, 17.16

LGP2

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
588.510511216322, 900.4070859136602
413.5076882358175, 375.00604128648655

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
633.1724216775461, 909.294183919118
241.79034284180054, 363.45554720168695

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
593.9007417892283, 905.4123000170734
402.7272270900053, 364.99561307966036

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
594.670774728215, 906.18233295606
401.1871612120314, 363.45554720168695

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
588.510511216322, 900.4070859136602
413.5076882358175, 375.00604128648655

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
588.510511216322, 900.4070859136602
413.5076882358175, 375.00604128648655

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
594.670774728215, 906.18233295606
401.1871612120314, 363.45554720168695

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
890.363423299079, 1054.4136737109852
25.833688341296302, 23.386286287910348

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
822.6005246682562, 1162.2182851691136
73.15312920372936, 66.22283275284978

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
588.510511216322, 900.4070859136602
413.5076882358175, 375.00604128648655

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
742.5, 500.0
19.784535910681544, 24.225962339610053

DDX58:LGP2

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
685.9719466858888, 1067.056671960945
13.095180900703635, 6.30508710033879

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
685.5346615286365, 1048.2534101990914
44.82172861837241, 80.67911151307025

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
704.3379232904903, 1100.7276290693815
6.996562516038611, 6.9965625160386065

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
916.5, 441.0
15.612146459109841, 30.217057662793255

TLR7:ssRNA

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p43

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
856.5, 497.0
15.571365928524443, 30.138127603595706

TLR8:ssRNA

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1078.0, 268.0
54.149377593360995, 14.439834024896266

CpG DNA

--

e65

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
912.5, 282.0
14.687787765840826, 28.427976320982243

TLR9:CpGDNA

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
822.0, 323.0
20.558823529411768, 34.26470588235295

CpGDNA:TLR9:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42 p47

p44

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
810.0, 263.0
20.558823529411768, 34.26470588235295

CpGDNA:TLR9:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7{p}

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

p47

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
812.0, 423.0
15.529411764705884, 25.88235294117647

ssRNA:TLR7:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43 p46

p45

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
181.08693546231487, 137.63980910755205
889.8434936394063, 1260.8852455997492

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
792.0, 475.0
15.529411764705884, 25.88235294117647

ssRNA:TLR7:MyD88:IRAK:IRAK-4:IKK-alpha:IRF-7{p}

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p45

p46

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
868.0, 952.0
24.0, 24.0

IRF-7

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46 p47

p48

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
987.0, 580.0
10.30028063610851, 23.769878391019642

RLHs

--

e72

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p49

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
943.5, 634.0
16.689885019163476, 20.436593901016497

dsRNA:RLHs

--

e73

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
501.0, 438.5
37.55755316816487, 19.404735803551855

ssRNA

--

e75

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
534.5, 524.0
19.66205632394601, 24.0759873354441

ssRNA:DDX58

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p52 p53

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
722.5, 638.0
19.52321526885667, 27.24169572398606

ssRNA:DDX58{ub}:MAVS

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p7

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
790.5, 672.0
19.2619563406099, 23.586068988501925

PolyI:C:IFIH1

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p3

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
698.5, 758.0
19.53110662506882, 27.25270691870068

PolyI:C:IFIH1:MAVS

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p8

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
184.26599348827312, 159.89321528925979
853.6374666190181, 1239.4816015308136

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
461.0, 729.0
29.85304408677397, 22.887333799860045

TRAF3{ub}

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p55

p7 p8

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
270.0, 631.0
11.467726847521046, 26.46398503274088

DUBA

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p55

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
192.74348155749507, 182.1466214709676
849.7401433343927, 1223.2261109127248

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
625.0, 485.0
21.0, 21.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m41844*m5*0.1

nodelay

--

true

0

false

PMID: 18272355 LGP2 also contains an RD, and this RD was found to interact with the RD of RIG-I and suppress its self-association.

Go back
310.0, 774.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000019331 MO000016608

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m17*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7

Go back
386.0, 894.0
19.0, 19.0

p10

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016608 MO000019331 e20

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c22 : 1
stoichiometry:c39 : 1

m1599*m3902*m20*0.1

nodelay

--

true

0

false

PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7

Go back
313.0, 1057.0
21.0, 21.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e21 MO000007694

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m21*m977*0.1

nodelay

--

true

0

false

PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7

Go back
389.0, 1093.0
21.0, 21.0

p12

p13

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m977*m23*0.1

nodelay

--

true

0

false

PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7

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457.0, 1057.0
21.0, 21.0

p12

p14

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e21 e25

MO000007702

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m21*m25*0.1

nodelay

--

true

0

false

PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7

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533.0, 1013.0
21.0, 21.0

p12

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e23 e25

MO000007702

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m23*m25*0.1

nodelay

--

true

0

false

PMID: 18272355 TRAF3 recruits and activates two IKK-related kinases, designated TANK-binding kinase 1 (TBK1) and inducible I¦ÊB kinase (IKK-i; also known as IKKvar epsilon), which phosphorylate IRF-3 and IRF-7

Go back
337.0, 1249.0
21.0, 21.0

p16

p16

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e24

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
429.0, 1221.0
21.0, 21.0

p16

p17

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000007702

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1

m980*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
522.0, 1190.0
19.0, 19.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000007702

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m24*m980*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
606.0, 1234.0
20.0, 20.0

p19

p19

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c62 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
569.0, 621.0
21.0, 21.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e16

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c157 : 1
stoichiometry:c151 : 1

m68199*m16*0.1

nodelay

--

true

0

false

PMID:18272355,16127453,16125763,16153868,16177806 RIG-I and MDA5 associate with an adaptor protein, IFN-¦Â promoter stimulator 1 (IPS-1; also known as MAVS, VISA or CARDIF), which also contains a CARD

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574.0, 1186.0
20.0, 20.0

p19

p20

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e27

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c63 : 1

m27*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
658.0, 1282.0
20.0, 20.0

p19

p21

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e26

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c64 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
646.0, 1078.0
19.0, 19.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c71 : 1

m30*m32*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
706.0, 1154.0
19.0, 19.0

p22

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e29 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c72 : 1

m29*m32*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
786.0, 1174.0
19.0, 19.0

p22

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e32

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c73 : 1

m31*m32*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
726.0, 950.0
19.0, 19.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e33

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
774.0, 1090.0
19.0, 19.0

p25

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e33

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
790.0, 1042.0
19.0, 19.0

p25

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e34

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
874.0, 1074.0
19.0, 19.0

p25

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e34

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
870.0, 1122.0
19.0, 19.0

p25

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
697.0, 673.0
21.0, 21.0

p2

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e78

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c154 : 1
stoichiometry:c8 : 1

m68199*m79*0.1

nodelay

--

true

0

false

PMID:18272355,16127453,16125763,16153868,16177806 RIG-I and MDA5 associate with an adaptor protein, IFN-¦Â promoter stimulator 1 (IPS-1; also known as MAVS, VISA or CARDIF), which also contains a CARD

Go back
910.0, 1138.0
19.0, 19.0

p25

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18272355,15800576 Phosphorylation of IRF-3 and IRF-7 by these kinases induces the formation of homodimers and/or heterodimers , which translocate into the nucleus and bind to IFN-stimulated response elements (ISREs), thereby resulting in the expression of type I IFN genes and a set of IFN-inducible genes.

Go back
278.0, 346.0
19.0, 19.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016899 MO000016900

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m1814*m1815*0.1

nodelay

--

true

0

false

PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1

Go back
362.0, 346.0
19.0, 19.0

p31

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016899 MO000016906

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m1814*m1821*0.1

nodelay

--

true

0

false

PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1

Go back
362.0, 466.0
19.0, 19.0

p31

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016899 MO000094908

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m1814*m68199*0.1

nodelay

--

true

0

false

PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1

Go back
326.0, 542.0
19.0, 19.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 MO000000058

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m40*m41*0.1

nodelay

--

true

0

false

PMID: 18272355,16585540 In addition, FAS-associated death domain-containing protein (FADD) interacts with caspase-8, caspase-10 and IPS-1, and the FADD-dependent pathway is responsible for the activation of NF-¦ÊB downstream of IPS-1

Go back
606.0, 90.0
19.0, 19.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016660 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m1636*m43*0.1

nodelay

--

true

0

false

PMID: 18272355,17332413 However, IKK-i is also activated by IFN-¦Â to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene

Go back
553.0, 341.0
21.0, 21.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e43 MO000016608

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m44*m1599*0.1

nodelay

--

true

0

false

PMID: 18272355,17332413 However, IKK-i is also activated by IFN-¦Â to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene

Go back
705.0, 377.0
21.0, 21.0

p37

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000013119 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c106 : 1
stoichiometry:c105 : 1

m1357*m45*0.1

nodelay

--

true

0

false

PMID: 18272355,17332413 However, IKK-i is also activated by IFN-¦Â to directly phosphorylate STAT1, thereby controlling a set of IFN-inducible genes such as the dsRNA-activated adenosine deaminase gene

Go back
978.0, 334.0
19.0, 19.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.

Go back
982.0, 398.0
19.0, 19.0

p38

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000042126

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m63*m19940*0.1

nodelay

--

true

0

false

PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.

Go back
726.0, 546.0
20.0, 20.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 MO000070429

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m41844*m45270*0.1

nodelay

--

true

0

false

PMID: 18272335,17709747 Recently, IPS-1 and RIG-I were found to associate with Atg5?Atg12 conjugates, which are essential components for autophagy

Go back
962.0, 462.0
19.0, 19.0

p38

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000042007

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m63*m19823*0.1

nodelay

--

true

0

false

PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.

Go back
966.0, 254.0
19.0, 19.0

p38

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 MO000042012

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m66*m19828*0.1

nodelay

--

true

0

false

PMID: 18272355 TLR3 detects double-stranded (ds) RNA, while TLR7 and TLR8 recognize single-stranded (ss) RNA and TLR9 recognizes unmethylated DNA with CpG motifs.

Go back
693.0, 285.0
21.0, 21.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000000213 MO000039077 MO000000210 e66 e25

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c132 : 1
stoichiometry:c124 : 1

m1572*m184*m17258*m181*m67*m25*0.1

nodelay

--

true

0

false

PMID: 18272355,15492225,15361868 pDCs produce huge amounts of type I IFNs in response to virus infections, and TLR signaling is essential for type I IFN production by pDCs. TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes

Go back
761.0, 357.0
21.0, 21.0

p42

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 MO000000213 MO000039077 MO000000210 e63 e25

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c130 : 1

m1572*m184*m17258*m181*m64*m25*0.1

nodelay

--

true

0

false

PMID: 18272355,15492225,15361868 pDCs produce huge amounts of type I IFNs in response to virus infections, and TLR signaling is essential for type I IFN production by pDCs. TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes

Go back
755.0, 283.0
17.0, 17.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes

Go back
731.0, 391.0
17.0, 17.0

p44

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes

Go back
854.0, 846.0
19.0, 19.0

p46

p46

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e70

e71 e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes

Go back
710.0, 842.0
19.0, 19.0

p46

p47

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e68

e67 e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes

Go back
922.0, 986.0
19.0, 19.0

p48

p48

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e71

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 18272355,15492225,15361868 TLR7 and TLR9 are highly expressed on pDCs, and stimulation with viral RNA and DNA induces the recruitment of a complex of MyD88, IRAK-1, IRAK-4, IKK-alpha and IRF-7 to the receptor, thereby leading to the phosphorylation and nuclear translocation of IRF-7 to activate the expression of IFN-inducible genes

Go back
961.0, 521.0
17.0, 17.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e72 MO000022224

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c165 : 1
stoichiometry:c147 : 1

m73*m119368*0.1

nodelay

--

true

0

false

PMID: 18272355 RLHs interact with dsRNAs through their helicase domain, and dsRNA stimulation induces their ATP catalytic activity.

Go back
522.0, 602.0
20.0, 20.0

p4

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 MO000070429

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m68199*m45270*0.1

nodelay

--

true

0

false

PMID: 18272335,17709747 Recently, IPS-1 and RIG-I were found to associate with Atg5?Atg12 conjugates, which are essential components for autophagy

Go back
438.0, 458.0
19.0, 19.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e75 MO000066987

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m76*m41844*0.1

nodelay

--

true

0

false

PMID: 18272355,17038590,17038589 On the other hand, RIG-I, but not MDA5, recognizes 5¡ì-triphosphate ssRNA synthesized by T7 polymerase in vitro

Go back
815.0, 731.0
17.0, 17.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e15

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c27 : 1
stoichiometry:c153 : 1

m76904*m15*0.1

nodelay

--

true

0

false

Go back
638.0, 710.0
19.0, 19.0

p52

p52

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000090351 e76

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c38 : 1
stoichiometry:c156 : 1

m63891*m77*0.1

nodelay

--

true

0

false

PMID: 18272355,17392790 First, the CARDs of RIG-I undergo Lys 63-linked ubiquitination by tripartite motif (TRIM) 25, a ubiquitin E3 ligase composed of a RING finger domain, a B box/coiled-coil domain and a SPRY domain

Go back
369.0, 557.0
21.0, 21.0

p53

p53

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000107907 e76

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c158 : 1
stoichiometry:c159 : 1

m80707*m77*0.1

nodelay

--

true

0

false

PMID: 18272355,17460044 On the other hand, RIG-I also undergoes ubiquitination by the ubiquitin ligase RNF125, which leads to its proteasomal degradation

Go back
426.0, 598.0
19.0, 19.0

p54

p54

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e16

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 18272355,17460044 On the other hand, RIG-I also undergoes ubiquitination by the ubiquitin ligase RNF125, which leads to its proteasomal degradation

Go back
450.0, 682.0
19.0, 19.0

p55

p55

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016963 e81

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c164 : 1
stoichiometry:c163 : 1

m1872*0.1

nodelay

--

true

0

false

PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain PMID: 18272355,17991829 Recently, a deubiquitinase named DUBA was shown to deubiquitinate TRAF3 and suppress RLH signaling

Go back
529.0, 857.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019326 e19 e18 e12

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c21 : 1
stoichiometry:c26 : 1

m3897*m19*m18*m12*0.1

nodelay

--

true

0

false

PMID: 18272355 Subsequently, TRAF3 recruits TANK/NAP1/SINTBAD and TBK1/IKK-i, which phosphorylate IRF-3 and IRF-7. PMID: 18272355 TBK1 and IKK-i interact with TRAF family member-associated NF-¦ÊB activator (TANK), NAK-associated protein 1 (NAP1) and similar to NAP1 TBK1 adaptor (SINTBAD).

Go back
525.0, 701.0
21.0, 21.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e77 e80

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c17 : 1
stoichiometry:c6 : 1

m78*m81*0.1

nodelay

--

true

0

false

PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain

Go back
565.0, 761.0
21.0, 21.0

p7

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e79 e80

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c19 : 1
stoichiometry:c9 : 1

m80*m81*0.1

nodelay

--

true

0

false

PMID:18272355,16306937,16306936 IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain

Go back
397.0, 785.0
21.0, 21.0

p6

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000019326 e19 e11

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c16 : 1
stoichiometry:c31 : 1

m18*m3897*m19*m11*0.1

nodelay

--

true

0

false

PMID: 18272355 Subsequently, TRAF3 recruits TANK/NAP1/SINTBAD and TBK1/IKK-i, which phosphorylate IRF-3 and IRF-7. PMID: 18272355 TBK1 and IKK-i interact with TRAF family member-associated NF-¦ÊB activator (TANK), NAK-associated protein 1 (NAP1) and similar to NAP1 TBK1 adaptor (SINTBAD).

Go back
590.0, 501.19776902317903

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
590.0, 515.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.0, 106.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.5617174213495, 171.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
268.0, 368.3696213940945

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.0, 352.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 388.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.0, 398.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 360.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
940.0, 337.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.0, 344.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.5508668509282, 347.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
753.3668216987254, 563.1192848634242

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 408.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.0, 408.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.5538553641524, 415.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.2339891739679, 417.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.0, 473.488880506236

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
879.5110105270928, 476.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.9705644626828, 265.6856399537792

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.0, 260.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.9678277419434, 270.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
712.4190369351473, 230.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.0, 563.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
687.0, 242.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.0, 253.0

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 296.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.0, 296.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 299.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
742.0, 230.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.0, 242.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.0, 255.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 300.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.9269205859564, 378.00222078299703

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0982264096656, 628.8705560397335

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.0, 378.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 385.6626102817692

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
554.0, 313.8604627066094

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
778.5538553641524, 302.5876987549066

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.0, 283.64808384839876

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.3292586792176, 407.2065506721577

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 408.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.0, 501.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.0, 865.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
821.8416507281808, 456.95560331161334

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.0, 612.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.3737806671201, 297.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.0, 364.81551538713416

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 858.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
892.0, 971.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
921.9220899170605, 1005.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
975.6906911759853, 545.5339352927587

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.2350150421889, 538.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.71811056990185, 453.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
464.5962214502056, 473.50946601480007

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.78467530313964, 541.4114649062071

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 474.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 633.0

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.6518186410233, 655.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.1513543886333, 703.3531602401445

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.0, 684.0

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.0, 772.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
650.0, 588.830325002023

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
596.7458175844586, 575.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.8548900981978, 538.0

c158

c158

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
390.0, 568.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
426.0, 796.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.8939776086863, 570.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 617.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.292693779412, 651.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
463.0, 701.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
281.0, 645.0

c164

c164

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
980.4832754728017, 354.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.0, 720.4063762906391

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
839.7538461538461, 722.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
491.0, 745.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
633.0, 453.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 868.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.5202885905017, 823.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
411.4, 876.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.5136810560396, 885.1870748873536

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.0, 885.5067449345369

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.9893198795369, 721.4132406834243

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
464.0, 868.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.0, 756.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
419.57745276819264, 812.5610156344095

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.6710786061416, 801.2703640717729

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 497.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.14929353968995, 809.1172442742875

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
389.44807344330496, 736.6162284902821

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.981966459253, 725.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 723.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
271.0, 758.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 793.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.0, 763.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
324.0, 723.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
551.0, 548.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 913.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.25733059193243, 585.6749240125702

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.0, 933.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
273.0, 1084.3024573305795

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
327.0, 1078.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
275.0, 1109.2864409730728

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
397.0, 1039.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
370.7980333239857, 1114.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
332.0, 925.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
485.5005297472795, 1074.7824545836681

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
468.0, 1078.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 1020.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
580.0, 650.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
545.8834522085988, 1041.951069877389

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
479.0873076132286, 1034.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.03594639423716, 1211.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
350.0, 1270.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.6487017042326, 1164.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 1242.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
375.0, 1200.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
480.0, 1161.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 1209.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
578.0, 1253.9691115068547

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 722.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
478.0, 1210.232240700761

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 1294.166350316796

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
626.0, 1213.9189895918717

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.0, 1154.1927794053147

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.0, 1238.7681096107117

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.5689290811055, 1104.8446454055274

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
673.0, 1088.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.0, 1180.8911513906571

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.9402850002907, 1094.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
806.4920113466981, 1199.619806195134

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
594.0, 685.4652307417023

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.0, 1094.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.0, 1047.5174713247359

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.0, 1145.0680750636075

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.0, 1184.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.0, 976.9903426964997

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
745.0, 960.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 1043.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 1046.7497264551948

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
803.8071238561463, 1068.7932216296308

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
803.0, 977.5573893138783

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
708.0, 694.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 1097.0950515759703

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
889.0, 1050.0144992693706

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
873.0, 1148.8968438219806

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
837.1306830355181, 977.7110433666369

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.0, 1160.8350918509939

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
913.504258435641, 1050.9840918976479

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
303.3520444365522, 367.8632840217353

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 373.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 322.0455126623185

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.0, 373.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 777.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
389.0, 356.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
381.0, 312.89497719930716

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.0, 431.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.55198556952405, 490.75981390635116

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.0, 476.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
288.0, 487.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
270.0, 552.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.17528920548375, 561.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 67.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 115.81326653363635

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back