1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18280610.csml convertedTime:2009.07.01.11:16

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Toll-like receptors regulation of viral infection and disease.
Authors Thompson JM, Iwasaki A.
Affiliation Department of Immunobiology, Yale University School of Medicine, New Haven, CT06520, USA.
Abstract In recent years, it has become increasingly evident that mammalian Toll-likereceptors (TLRs) play a critical role in determining the outcome of virusinfection. TLRs have evolved to recognize viral nucleic acids, and promote thestimulation of innate and adaptive immune responses. Interestingly, the study ofmice harboring deficiencies in various TLR proteins and their adaptors suggeststhat TLR activation promotes protective anti-viral immunity in some cases, whileexacerbating virus-induced disease in others. In this report we describe theinteractions of viruses with both the TLR system and the intracellularrecognition system and highlight the role of TLRs in shaping the outcome ofvirus infection in both a positive and negative manner.
PMID 18280610
Model Abstract

Entity

G010262:IL-6 G010389:IL-1beta G011345:IL10 G016992:IFN-alpha1 G030474:CD150 MO000000058:NF-kappaB MO000016573:MyD88 MO000016658:IFN Type I MO000017247:IL-10 MO000019387:cytokines MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000022224:dsRNA MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000061281:RNASEL MO000061425:DAI MO000068831:MAL MO000094908:MAVS MO000103999:Mda-5 e1: e10: e11: e12:RIG-1 e13:dsRNA: RIG-1 e14:dsRNA: Mda-5 e15: e16: e17: e18: e19: e2: e20: e21: e22: e23: e24:dsRNA: Mda-5: MAVS e25:dsRNA: RIG-1: MAVS e26:CpG DNA e27:ssRNA e28:poly I: C e29:poly I: C: TLR3 e3: e30:ssRNA: TLR7 e31:imidazoquinoline: TLR7 e32:imidazoquinoline e33:ssRNA: TLR8 e34:CpG DNA: TLR9 e35:chloroquine e36:bafilomycin e37:MyD88: IRF-7 e38:CpG DNA: TLR9: MyD88: IRF-7 e39:B DNA e4: e40:B DNA: DAI e41:antiviral signaling complex e42:B: DNA: antiviral signaling complex e43:NF-kappaB{activated} e44:IFN Type I e45:UNC-93B e46:TLR3: UNC-93B e47:TLR9: UNC-93B e48:TLR7: UNC-93B e49:HSV viral ligand e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:HSV viral ligand: TLR2 e64:HA proteins of Measels virus e65:HA proteins of Measels virus: TLR2 e66:cytokines e67:MMTV env protein e68:MMTV env protein: TLR4 e69:TLR4 ligand: TLR4 e7: e70:TLR4 ligand: TLR4: MAL e71:TLR4 ligand: TLR4: MAL: MyD88 e72:TLR ligand: TLR e73:TLR ligand: TLR: MyD88 e74:TLR4 ligand: TLR4: TRAM e75:dsRNA: TLR3: TRIF e76:TLR4 ligand: TLR4: TRAM: TRIF e77:IRAK: TRAF6 e78:IRAK: TRAF6{activated} e79:synthetic poly U RNA e8: e80:synthetic poly U RNA: TLR7 e81:non-viral cellular RNA: TLR7 e82:non-viral cellular RNA e83:cellular RNA e84:cleaved RNA e85:cleaved RNA: Mda-5 e86:cleaved RNA: RIG-1 e87: e88: e89: e9: e90: e91: e92:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p5 p6 p7 p8 p9
Model Detail
678.0, 926.0
28.5, 28.5

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p37

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
638.0, 933.0
29.0, 29.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p36

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
677.0, 997.0
29.0, 29.0

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
624.0, 983.0
32.0, 32.0

IFN-alpha1

--

G016992

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m98717

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
736.0, 932.0
31.0, 31.0

CD150

--

G030474

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m109171

10

false

infinite

0

unit false false false
TRANSFACG030474

--

Go back
634.5, 727.0
34.5, 34.5

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p34

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
760.0, 216.0
33.5, 33.5

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28 p29

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
480.0, 999.0
32.5, 32.5

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p15

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
678.0, 1222.0
28.0, 28.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
1015.0, 1023.0
34.5, 34.5

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22 p40 p41 p42

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
902.0, 558.0
28.0, 28.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
913.0, 869.0
26.0, 26.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p21

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
290.0, 350.0
27.0, 27.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p16

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
125.0, 289.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p2 p5

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
549.0, 405.0
30.0, 30.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p32

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
780.0, 352.0
32.0, 32.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
332.0, 328.0
31.0, 31.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p31

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
277.0, 645.0
22.0, 22.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
298.0, 718.0
27.0, 27.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p18

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
288.0, 564.0
24.0, 24.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p8 p17 p38 p39

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
665.0, 177.0
30.0, 30.0

RNASEL

--

MO000061281

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m36179

10

false

infinite

0

unit false false false
TRANSPATHMO000061281

--

Go back
273.0, 1021.0
30.0, 30.0

DAI

--

MO000061425

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m36323

10

false

infinite

0

unit false false false
TRANSPATHMO000061425

--

Go back
825.0, 257.0
34.0, 34.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
610.0, 278.0
28.0, 28.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
332.0, 216.0
32.0, 32.0

Mda-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p44

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
187.9001979037943, 106.42668442858252
752.6195347358616, 1092.803564436471

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
191.7507145071778, 122.20619924060247
689.1848868331243, 969.489347618192

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
289.9295697191512, 342.9057895435496
260.50268332922406, 434.907022168281

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
336.5, 266.0
23.7609841827768, 36.55536028119508

RIG-1

--

e12

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1 p45

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
437.5, 283.0
21.382591536943654, 41.38566103924578

dsRNA: RIG-1

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
464.625, 228.5
31.099608398600232, 38.08115314114314

dsRNA: Mda-5

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p3

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
646.3839554797092, 304.8109107806556
0.7738001411450808, 0.7738001411450812

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
644.3527301092037, 299.05577223088903
4.957157154210681, 8.92288287757922

--

e16

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false true false

--

Go back
630.1251950077996, 266.54192667706695
42.94446177847103, 67.55897035881422

--

e17

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false true false

--

Go back
622.9677847113878, 260.34465678627123
57.25928237129464, 79.95351014040544

--

e18

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false true false

--

Go back
622.9677847113878, 260.34465678627123
57.25928237129464, 79.95351014040544

--

e19

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false true false

--

Go back
187.9001979037943, 106.42668442858252
752.6195347358616, 1092.803564436471

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
622.7932137285486, 260.170085803432
57.60842433697327, 80.30265210608408

--

e20

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false true false

--

Go back
630.1251950077996, 266.54192667706695
42.94446177847103, 67.55897035881422

--

e21

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false true false

--

Go back
622.9677847113878, 260.34465678627123
57.25928237129464, 79.95351014040544

--

e22

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false true false

--

Go back
629.9506240249605, 266.3673556942275
43.29360374414965, 67.90811232449286

--

e23

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false true false

--

Go back
554.875, 281.5
26.284134703615344, 36.67553679574234

dsRNA: Mda-5: MAVS

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
569.875, 331.5
28.927739034685263, 40.36428702514223

dsRNA: RIG-1: MAVS

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
131.5, 725.125
45.0, 15.75

CpG DNA

--

e26

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
105.5, 647.625
45.0, 24.75

ssRNA

--

e27

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p8 p9

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
113.5, 387.25
45.0, 25.5

poly I: C

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
278.625, 383.5
27.400724879186797, 33.551908015330774

poly I: C: TLR3

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
202.95258859851154, 121.4790751232998
722.5147533464271, 1062.6987830470375

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
280.625, 601.5
29.8993084485919, 36.61139810031661

ssRNA: TLR7

--

e30

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

p26 p42

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
289.625, 518.5
28.119271788035327, 34.43176137310448

imidazoquinoline: TLR7

--

e31

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p7

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
115.5, 564.25
41.54331370899916, 23.541211101766187

imidazoquinoline

--

e32

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p7

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
275.625, 678.5
29.58902682886186, 36.23146142309615

ssRNA: TLR8

--

e33

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p9

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
372.625, 764.5
31.09960839860024, 38.08115314114314

CpG DNA: TLR9

--

e34

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p10

p11

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
123.5, 772.25
45.0, 25.5

chloroquine

--

e35

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
119.5, 820.25
45.0, 25.5

bafilomycin

--

e36

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
360.625, 812.5
31.458881853024494, 38.521079820029996

MyD88: IRF-7

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
421.875, 745.5
32.25, 45.0

CpG DNA: TLR9: MyD88: IRF-7

--

e38

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p11

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
119.5, 977.125
45.0, 15.75

B DNA

--

e39

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p12

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
230.7995113837385, 147.8207588390548
666.8209077759735, 1010.0154156155264

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
320.625, 964.5
34.25958173637728, 41.95050824862522

B DNA: DAI

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
319.875, 1007.5
32.25, 45.0

antiviral signaling complex

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p13

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
391.875, 925.5
32.25, 45.0

B: DNA: antiviral signaling complex

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14 p15

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
596.5, 797.0
34.5, 34.5

NF-kappaB{activated}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p34

p35 p36 p37

true true true true

csml-variable:Double

m44

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
572.5, 949.0
39.965397923875436, 21.314878892733564

IFN Type I

--

e44

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35

p15

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
632.5, 378.125
30.956932984503926, 19.090108673777422

UNC-93B

--

e45

cso30:c:Protein

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

p16 p17 p18

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
454.625, 355.5
27.53953507748708, 33.72187968671888

TLR3: UNC-93B

--

e46

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p16

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
469.625, 717.5
29.49920846525579, 36.12147975337444

TLR9: UNC-93B

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
532.625, 553.5
29.907473754374266, 36.621396433927686

TLR7: UNC-93B

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1058.5, 868.375
34.490333919156406, 22.41871704745167

HSV viral ligand

--

e49

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p19

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
289.9295697191512, 342.9057895435496
260.50268332922406, 434.907022168281

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
533.4039717660083, 839.8194627296347
298.1945763009733, 270.42971817239146

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
565.6112071951637, 846.2282539073486
174.36330904749656, 262.10026073381675

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
537.2910519040099, 843.4288942863503
290.4204160249705, 263.21085505895996

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
537.8463490665814, 843.9841914489219
289.30982169982707, 262.10026073381675

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
533.4039717660083, 839.8194627296347
298.1945763009733, 270.42971817239146

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
533.4039717660083, 839.8194627296347
298.1945763009733, 270.42971817239146

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
537.8463490665814, 843.9841914489219
289.30982169982707, 262.10026073381675

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
751.0804594940932, 950.8788952439639
18.62955869597052, 16.864653135299662

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
702.2143091877887, 1028.620498003994
52.75323044430624, 47.75555598116156

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
533.4039717660083, 839.8194627296347
298.1945763009733, 270.42971817239146

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
289.9295697191512, 342.9057895435496
260.50268332922406, 434.907022168281

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
603.6867555747542, 959.9961949062881
9.443384080547013, 4.546814557300424

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
603.3714142500356, 946.4365179433905
32.322485783651395, 58.18047441057255

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
616.9310912129336, 984.2774769096169
5.045461195496798, 5.045461195496805

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
911.625, 815.5
29.499208465255787, 36.12147975337444

HSV viral ligand: TLR2

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p20

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1075.5, 921.375
33.47100175746924, 21.756151142355012

HA proteins of Measels virus

--

e64

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p21

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
915.625, 915.5
29.499208465255787, 36.12147975337444

HA proteins of Measels virus: TLR2

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p22 p23

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
748.5, 1041.0
39.965397923875436, 21.314878892733564

cytokines

--

e66

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p22 p40 p41 p42

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
979.5, 675.375
37.9701230228471, 24.680579964850615

MMTV env protein

--

e67

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p24

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
910.625, 604.5
31.099608398600232, 38.08115314114314

MMTV env protein: TLR4

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p25

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
910.625, 182.5
31.099608398600232, 38.08115314114314

TLR4 ligand: TLR4

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p27 p30

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
194.24181145386277, 110.5810801560728
697.2777445181742, 988.0245531180037

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
909.875, 239.5
32.25, 45.0

TLR4 ligand: TLR4: MAL

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p28

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
909.875, 299.5
32.25, 45.0

TLR4 ligand: TLR4: MAL: MyD88

--

e71

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p28

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
693.625, 118.5
30.07894517580403, 36.83136143976004

TLR ligand: TLR

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p29

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
752.875, 102.5
32.25, 45.0

TLR ligand: TLR: MyD88

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p33

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
917.875, 396.5
32.25, 45.0

TLR4 ligand: TLR4: TRAM

--

e74

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p32

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
523.875, 457.5
32.25, 45.0

dsRNA: TLR3: TRIF

--

e75

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p31

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
917.875, 452.5
32.25, 45.0

TLR4 ligand: TLR4: TRAM: TRIF

--

e76

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
669.625, 496.5
31.638518580236624, 38.74104315947342

IRAK: TRAF6

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
669.625, 552.5
31.638518580236624, 38.74104315947342

IRAK: TRAF6{activated}

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
117.5, 528.0
29.845283018867917, 32.558490566037726

synthetic poly U RNA

--

e79

cso30:c:RnaOther

cso30:i:CC_Extracellular

--

--

p38

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
196.73290840054767, 128.0187587828673
668.9068489177724, 971.2527446286063

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
282.625, 475.5
26.559698383602733, 32.5220796533911

synthetic poly U RNA: TLR7

--

e80

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p38

p41

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
280.625, 433.5
30.919971671388105, 37.861189801699716

non-viral cellular RNA: TLR7

--

e81

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p39

p40

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
227.5, 488.625
40.93090211132437, 22.511996161228407

non-viral cellular RNA

--

e82

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p39

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
599.5, 174.625
32.2936660268714, 17.76151631477927

cellular RNA

--

e83

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p43

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
519.5, 175.25
32.031118587047935, 18.150967199327162

cleaved RNA

--

e84

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p43

p44 p45

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
271.625, 169.5
24.159098483586064, 29.58256957173804

cleaved RNA: Mda-5

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
406.625, 183.5
27.13126978836861, 33.22196300616564

cleaved RNA: RIG-1

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
620.632452134865, 357.25
127.03897894029045, 38.39763350606859

--

e87

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false true false

--

Go back
620.632452134865, 357.25
127.03897894029045, 38.39763350606859

--

e88

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false true false

--

Go back
621.8579085233565, 358.4754563884915
124.58806616330745, 35.946720729085456

--

e89

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false true false

--

Go back
230.37583359170748, 191.45643740966176
665.8529222340502, 958.5150082567189

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
620.632452134865, 357.25
127.03897894029045, 38.39763350606859

--

e90

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false true false

--

Go back
622.4706367176024, 359.0881845827373
123.36260977481584, 34.72126434059391

--

e91

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false true false

--

Go back
622.879122180433, 359.49667004556784
122.54563884915483, 33.90429341493289

--

e92

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false true false

--

Go back
271.0, 291.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 MO000022224

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m12*m119368*0.1

nodelay

--

true

0

false

PMID: 18280610, 15208624, 15563593 RNA viruses are efficiently recognized by the cytoplasmic RNA helicases, retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). PMID: 18280610 Both of these proteins recognize viral RNA through their helicase domains.

Go back
223.0, 723.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e26 MO000042012 e35 e36

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1
stoichiometry:c30 : 1

m26*m19828*0.1

nodelay

--

true

0

false

PMID: 18280610, 11130078 In this case, it is the recognition of viral DNA that stimulates TLR9. Bacterial DNA sequences containing hypomethylated CpG motifs were first shown to activate TLR9. PMID: 18280610, 12900525 As predicted, this response was dependent upon acidification of the endosome, as treatment with chloroquine or bafilomycin [61] abrogated recognition.

Go back
422.0, 822.0
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e34 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m35*m38*0.1

nodelay

--

true

0

false

PMID: 18280610, 15815647 Furthermore, Honda et al. demonstrated that the ability of pDCs to retain the TLR9 ligand, CpG DNA, in the endosomal vesicle for long periods of time is critical to recruit a signaling complex containing MyD88 and the transcription factor IRF-7.

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221.0, 972.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000061425 e39

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m36323*m40*0.1

nodelay

--

true

0

false

PMID: 18280610, 17618271 Recently, Takaoka et al. identified the DAI protein (also known as DLM-1/ZBP1) as a candidate intracellular DNA sensing molecule. PMID: 18280610 DAI physically interacts with the B form of DNA in the cytosol and recruits an anti-viral signaling complex that results in the activation of NF-kappaB and the production of type I IFNs.

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393.0, 1019.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m41*m42*0.1

nodelay

--

true

0

false

PMID: 18280610 DAI physically interacts with the B form of DNA in the cytosol and recruits an anti-viral signaling complex that results in the activation of NF-kappaB and the production of type I IFNs.

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519.0, 799.0
29.0, 29.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c44 : 1
stoichiometry:c43 : 1

m30*m43*0.1

nodelay

--

true

0

false

PMID: 18280610 DAI physically interacts with the B form of DNA in the cytosol and recruits an anti-viral signaling complex that results in the activation of NF-kappaB and the production of type I IFNs.

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482.0, 945.0
26.0, 26.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e44 e42

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c45 : 1

m45*m43*0.1

nodelay

--

true

0

false

PMID: 18280610 DAI physically interacts with the B form of DNA in the cytosol and recruits an anti-viral signaling complex that results in the activation of NF-kappaB and the production of type I IFNs.

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391.0, 387.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000019398 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c48 : 1
stoichiometry:c54 : 1

m3965*m46*0.1

nodelay

--

true

0

false

PMID: 18280610, 17452530 Recently, Brinkmann et al. demonstrated a physical interaction between wild type, but not mutated, UNC-93B and all three endosomal TLRs (TLR3, 7, and 9).

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387.0, 499.0
26.0, 26.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e45 MO000042126

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c52 : 1
stoichiometry:c56 : 1

m46*m19940*0.1

nodelay

--

true

0

false

PMID: 18280610, 17452530 Recently, Brinkmann et al. demonstrated a physical interaction between wild type, but not mutated, UNC-93B and all three endosomal TLRs (TLR3, 7, and 9).

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375.0, 679.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e45 MO000042012

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c53 : 1
stoichiometry:c55 : 1

m46*m19828*0.1

nodelay

--

true

0

false

PMID: 18280610, 17452530 Recently, Brinkmann et al. demonstrated a physical interaction between wild type, but not mutated, UNC-93B and all three endosomal TLRs (TLR3, 7, and 9).

Go back
1013.0, 869.0
25.0, 25.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m3964*m63*0.1

nodelay

--

true

0

false

PMID: 18280610, 16177057 Of note, an additional report demonstrated that TLR2 induces apoptosis of HSV-infected microgial cells, potentially implicating microglial cells in the regulation of the inflammatory response following HSV infection.

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271.0, 235.0
25.0, 25.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 MO000022224

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m76904*m119368*0.1

nodelay

--

true

0

false

PMID: 18280610, 15208624, 15563593 RNA viruses are efficiently recognized by the cytoplasmic RNA helicases, retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). PMID: 18280610 Both of these proteins recognize viral RNA through their helicase domains.

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1007.0, 819.0
29.0, 29.0

p20

p20

cso30:i:CE_CellDeath

cso30:i:CC_Extracellular

--

e63

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18280610, 16177057 Of note, an additional report demonstrated that TLR2 induces apoptosis of HSV-infected microgial cells, potentially implicating microglial cells in the regulation of the inflammatory response following HSV infection.

Go back
1013.0, 921.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e64 MO000019397

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m65*m3964*0.1

nodelay

--

true

0

false

PMID: 18280610, 12163593 Recently, Bieback et al. demonstrated that the HA protein of Measles virus induces cytokine secretion in a TLR2-dependent manner.

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859.0, 975.0
25.0, 25.0

p22

p22

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e65

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c64 : 1

m67*m66*0.1

nodelay

--

true

0

false

PMID: 18280610, 12163593 Recently, Bieback et al. demonstrated that the HA protein of Measles virus induces cytokine secretion in a TLR2-dependent manner.

Go back
786.0, 918.0
27.0, 27.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

G030474

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18280610, 12163593 Interestingly, this interaction also results in upregulated expression of the MV receptor, CD150, suggesting that HA-TLR2 interactions in fact benefit the virus at the expense of the host unless increased infection can be viewed as an effective antiviral strategy.

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986.0, 612.0
24.0, 24.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e67

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m3961*m68*0.1

nodelay

--

true

0

false

PMID: 18280610, 12730691 Likewise, the interaction of the MMTV env protein with TLR4 provides a selective advantage to the virus by promoting infection of target cells, transcription of the viral genome, and release of the immunoregulatory cytokine, IL-10.

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679.0, 1115.0
25.0, 25.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e68

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c72 : 1

m94230*m69*0.1

nodelay

--

true

0

false

PMID: 18280610, 12730691 Likewise, the interaction of the MMTV env protein with TLR4 provides a selective advantage to the virus by promoting infection of target cells, transcription of the viral genome, and release of the immunoregulatory cytokine, IL-10.

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625.0, 1044.0
29.0, 29.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G016992

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c75 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18280610 For example, the induction of IFNalpha by VSV, SeV, and Flu in pDCs is completely dependent upon TLR7.

Go back
829.0, 189.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000068831

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m70*m43675*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
832.0, 308.0
27.0, 27.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 MO000016573

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m71*m1572*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
696.0, 220.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e72

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m1572*m73*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
524.0, 236.0
24.0, 24.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e14

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c9 : 1
stoichiometry:c11 : 1

m68199*m14*0.1

nodelay

--

true

0

false

PMID: 18280610, 16125763, 16127453, 16177806 Both RIG-I and MDA5 utilize a common adaptor molecule termed MAVS [29], IPS-1 [30], Cardif [31], or VISA [32], which was independently identified by multiple groups and localizes to the mitochondrial membrane.

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843.0, 355.0
25.0, 25.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041132 e69

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m19005*m70*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
486.0, 406.0
27.0, 27.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
845.0, 406.0
25.0, 25.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e74 MO000041125

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1

m75*m18998*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
736.0, 503.0
26.0, 26.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e77 e73

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c97 : 1
stoichiometry:c96 : 1

m78*m74*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
669.0, 798.0
27.0, 27.0

p34

p34

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e78

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c100 : 1
stoichiometry:c99 : 1

m30*m79*0.1

nodelay

--

true

0

false

PMID: 18280610, 15229469 TIR domain-containing adaptor molecules, MyD88, which is utilized by all TLRs except for TLR3, as well as TIRAP, TRIF, and TRAM (for TLR4), are recruited to the receptor and activate a complex containing IRAKs and TRAFs which signal through NF-kappaB.

Go back
597.0, 876.0
23.0, 23.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c101 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18280610 Ultimately, TLR stimulation culminates in the synthesis of antiviral cytokines, such as type I IFNs, IL-1beta, and IL-6, which may directly suppress viral replication.

Go back
641.0, 876.0
23.0, 23.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c103 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18280610 Ultimately, TLR stimulation culminates in the synthesis of antiviral cytokines, such as type I IFNs, IL-1beta, and IL-6, which may directly suppress viral replication.

Go back
678.0, 853.0
25.0, 25.0

p37

p37

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18280610 Ultimately, TLR stimulation culminates in the synthesis of antiviral cytokines, such as type I IFNs, IL-1beta, and IL-6, which may directly suppress viral replication.

Go back
212.0, 532.0
23.0, 23.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e79

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m19940*m80*0.1

nodelay

--

true

0

false

PMID: 18280610, 14976261, 14976262, 17111347 TLR7 recognition of viral RNA, synthetic polyU RNA, and even non-viral, cellular RNA in the endosome is sufficient to stimulate TLR7-dependent cytokine production.

Go back
243.0, 439.0
25.0, 25.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042126 e82

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m19940*m83*0.1

nodelay

--

true

0

false

PMID: 18280610, 14976261, 14976262, 17111347 TLR7 recognition of viral RNA, synthetic polyU RNA, and even non-viral, cellular RNA in the endosome is sufficient to stimulate TLR7-dependent cytokine production.

Go back
523.0, 339.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e13

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c12 : 1

m68199*m13*0.1

nodelay

--

true

0

false

PMID: 18280610, 16125763, 16127453, 16177806 Both RIG-I and MDA5 utilize a common adaptor molecule termed MAVS [29], IPS-1 [30], Cardif [31], or VISA [32], which was independently identified by multiple groups and localizes to the mitochondrial membrane.

Go back
859.0, 1011.0
25.0, 25.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e81

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c128 : 1
stoichiometry:c116 : 1

m67*m82*0.1

nodelay

--

true

0

false

PMID: 18280610, 14976261, 14976262, 17111347 TLR7 recognition of viral RNA, synthetic polyU RNA, and even non-viral, cellular RNA in the endosome is sufficient to stimulate TLR7-dependent cytokine production.

Go back
859.0, 1047.0
25.0, 25.0

p41

p41

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e66 e80

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c129 : 1
stoichiometry:c117 : 1

m67*m81*0.1

nodelay

--

true

0

false

PMID: 18280610, 14976261, 14976262, 17111347 TLR7 recognition of viral RNA, synthetic polyU RNA, and even non-viral, cellular RNA in the endosome is sufficient to stimulate TLR7-dependent cytokine production.

Go back
860.0, 1084.0
23.0, 23.0

p42

p42

cso30:i:ME_Translation

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

e66 e30

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c130 : 1
stoichiometry:c118 : 1

m67*m31*0.1

nodelay

--

true

0

false

PMID: 18280610, 14976261, 14976262, 17111347 TLR7 recognition of viral RNA, synthetic polyU RNA, and even non-viral, cellular RNA in the endosome is sufficient to stimulate TLR7-dependent cytokine production.

Go back
601.0, 217.0
30.0, 30.0

p43

p43

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e83 MO000061281

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c121 : 1
stoichiometry:c120 : 1

m84*m36179*0.1

nodelay

--

true

0

false

PMID: 18280610, 17653195 The authors demonstrated that cellular RNAs cleaved by the antiviral endoribonuclease, RNaseL, which contain 3' monophosphoryl group, efficiently serve as a ligand for both RIG-I and MDA5.

Go back
335.0, 171.0
25.0, 25.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e84

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m76904*m85*0.1

nodelay

--

true

0

false

PMID: 18280610, 17653195 The authors demonstrated that cellular RNAs cleaved by the antiviral endoribonuclease, RNaseL, which contain 3' monophosphoryl group, efficiently serve as a ligand for both RIG-I and MDA5.

Go back
468.0, 200.0
23.0, 23.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e84

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1

m12*m85*0.1

nodelay

--

true

0

false

PMID: 18280610, 17653195 The authors demonstrated that cellular RNAs cleaved by the antiviral endoribonuclease, RNaseL, which contain 3' monophosphoryl group, efficiently serve as a ligand for both RIG-I and MDA5.

Go back
203.0, 331.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18280610, 16641297 Double stranded RNA intermediates are produced during the replication cycle of most viruses, including viruses with DNA genomes [47], and these RNA secondary structures are thought to be recognized by TLR3.

Go back
212.0, 388.0
24.0, 24.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e28 MO000019398

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m28*m3965*0.1

nodelay

--

true

0

false

PMID: 18280610, 16625202, 16714379 It is clear that TLR3 responds to the artificial dsRNA mimic, polyiosinic-polycytidylic acid (polyIC), when it is provided extracellularly.

Go back
212.0, 564.0
24.0, 24.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e32 MO000042126

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m33*m19940*0.1

nodelay

--

true

0

false

PMID: 18280610, 11812998 TLR7 was originally shown to be responsible for mediating the antiviral effects induced following delivery of imidazoquinoline compounds.

Go back
208.0, 608.0
24.0, 24.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042126 e27

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19940*m27*0.1

nodelay

--

true

0

false

PMID: 18280610, 15123819 It is now clear that TLR7 and TLR8 recognize single stranded RNA (ssRNA) and induce innate immune responses to ssRNA-viruses. PMID: 18280610, 14976262 TLR7-dependent signaling was also induced following delivery of single stranded RNA oligonucleotides derived from human immunodeficiency virus (HIV) RNA.

Go back
207.0, 683.0
26.0, 26.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042007 e27

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19823*m27*0.1

nodelay

--

true

0

false

PMID: 18280610, 15123819 It is now clear that TLR7 and TLR8 recognize single stranded RNA (ssRNA) and induce innate immune responses to ssRNA-viruses.

Go back
303.67789925606615, 288.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
459.0, 310.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0772910784721, 591.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.7188942614009, 899.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
610.544191105099, 832.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
653.0, 899.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.0, 832.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.0, 825.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
691.0, 878.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
242.38873330800013, 552.0670213731321

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
147.0, 544.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.0, 506.62413872624273

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 260.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
262.70975574618194, 471.52709929494983

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
250.0, 471.89952505533364

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.0, 452.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.0, 1029.0680750636075

c113

c113

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.0, 1054.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
788.0, 1061.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
884.0, 1025.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.0, 1042.9698918137258

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.0, 1048.6326040130368

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
616.0, 192.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 352.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
558.8228104326101, 197.17723087710823

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
637.7165612572172, 201.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
348.0, 204.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 184.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
304.0, 184.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 222.7850131036545

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.2044130909166, 193.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
441.8356563460532, 204.6132233653639

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
95.83190303566937, 75.58968053273156

c128

c128

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
79.57546412588874, 63.596184647693974

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
139.5882126811424, 319.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
92.17718399243194, 622.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
235.80352801654166, 348.7620869714772

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 344.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
159.0, 400.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.25973525695872, 370.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 400.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
157.0, 576.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 304.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 576.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
236.0, 546.5777087639997

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
239.05183976023025, 583.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
127.88371093397879, 619.7095184675736

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.0, 620.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
239.8874122257145, 662.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
128.0, 672.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
233.0, 696.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
177.0, 734.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
255.99360766977432, 733.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 304.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
248.0, 740.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
169.0, 744.9425717247145

c31

c31

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
154.0, 750.8679796752577

c32

c32

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
404.0, 801.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.0, 833.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.0, 798.9958409147176

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.76256170793184, 1001.549133496527

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
165.0, 985.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
246.0, 985.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
355.0, 997.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.76114000116263, 236.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.0, 1031.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
406.0, 978.9982644538248

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.8668979852083, 754.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 814.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 833.8239396935238

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
495.0, 971.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
515.9962157046132, 958.2460374062958

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
424.0, 950.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
423.9999925444878, 397.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.9999972331136, 397.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
140.0, 248.01967848722884

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.99998883881005, 397.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.0, 369.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 524.3124295713869

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
325.0, 702.6908218931359

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 381.19668336411144

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 697.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
399.7583281141904, 525.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
939.0, 882.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1045.9909451017954, 881.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.1949428331061, 844.4975416549821

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
296.0, 248.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.0, 834.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1045.9972313548228, 933.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
939.0, 889.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.0, 934.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
884.0, 992.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.0, 1000.1979831203844

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
889.8362976331207, 947.0

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
774.6286613210731, 937.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.9984922728852, 932.1553105295706

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
930.0, 572.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.1554175279994, 257.5777087639997

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 644.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
950.0, 624.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.0, 1140.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.0, 1026.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.9999998953532, 630.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
640.0, 1023.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
63.75120565719851, 588.3459954652583

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
862.0, 202.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.0, 222.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.0, 211.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.6233495239067, 302.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.4150626209072, 274.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
776.3635894708144, 250.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
859.0, 322.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.0, 233.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
709.0, 155.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.0, 154.9932582089723

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.0, 368.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.9999551823217, 199.68018466804045

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 376.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.0, 351.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 248.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
521.0, 420.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 433.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
878.0, 419.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
870.0, 428.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.0, 419.0300749754447

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 516.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
706.9887054413853, 527.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
750.4051133803574, 148.0

c97

c97

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
660.0, 762.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.9972313548228, 812.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back