1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18280611.csml convertedTime:2009.07.01.11:16

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Cytosolic DNA recognition for triggering innate immune responses.
Authors Takaoka A, Taniguchi T.
Affiliation Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine,Hokkaido University, Sapporo, Japan. takaoka@igm.hokudai.ac.jp
Abstract The detection of microbial components by pattern recognition receptors (PRRs)and the subsequent triggering of innate immune responses constitute the firstline of defense against infections. Recently, much attention has been focused oncytosolic nucleic acid receptors; the activation of these receptors commonlyevokes a robust innate immune response, the hallmark of which is the inductionof type I interferon (IFN) genes. In addition to receptors for RNA, receptorsthat detect DNA exposed in the cytosol and activate innate immune responses havelong been thought to exist. Recently, DAI (DLM-1/ZBP1) has been identified as acandidate cytosolic DNA sensor. Cytosolic signaling by DNA-activated DAI(DLM-1/ZBP1) signaling results in activation of the two pathways of genetranscription critical to innate immune responses, the IRF and NF-kappaBpathways. In this review, we summarize our current view of activation mechanismand immunological roles of DAI (DLM-1/ZBP1) and related molecules. In addition,we also discuss the issue of self vs. non-self DNA recognition by DAI(DLM-1/ZBP1) and other DNA sensors in terms of the possible involvement inautoimmune abnormalities.
PMID 18280611
Model Abstract

Entity

G010228:IFN-beta MO000007694:IRF-3 MO000016573:MyD88 MO000016660:IFNbeta MO000016665:IFNgamma MO000019331:TBK1 MO000019398:TLR3 MO000022224:dsRNA MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042409:LPS MO000066987:DDX58 MO000088437:IRF-3{p}:IRF-3{p} MO000094908:MAVS MO000103999:IFIH1 e1: e10:L.monocytogenes e11: e12:ssRNA e13:ssRNA:TLR7 e14:ssRNA:TLR8 e15:dsRNA e16:CpG DNA e17:TLR9:CpG DNA e18:DDX58:dsRNA e19:PKZ e2: e20:Poly(rI:rC) e21:DAI e22:Z-DNA e23:DAI:ZDNA e24:ADAR1 e25:ADAR1:ZDNA e26:SmtB e27:DAI:SmtB e28:Mar e29:DAI:Mar e3: e30:ADARs e31:SmtB:ADARs e32:ADARs:Mar e33:ADARs:dsRNA e34:dsRNA:IFIH1 e35:ssRNA e36:ssRNA:DDX58 e37:DLM-1 e38:IFN-alpha e39:S.flexneri e4: e40:enterophathogenic e.coli e41:L.pnemophila e42:Type I IFN e43:ISD e44:B-DNA e45:E3L e46:E3L:dsRNA e47:DAI:B-DNA e48:DAI:B-DNA:IRF-3:TBK1 e49:IRF-3{p}:IRF-3{p} e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:IFN-alpha e64:DDX58:dsRNA:MAVS e65:TLr9:CpG DNA:MyD88 e66:ssRNA:TLR8:MyD88 e67:ssRNA:TLR7:MyD88 e68:IFIH1:dsRNA:MAVS e69:Atg5:Atg12 e7: e70:Atg5:Atg12:DDX58:dsRNA:MAVS e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p5 p6 p7 p8 p9
Model Detail
589.0, 1069.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p33

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
640.0, 756.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
918.0, 762.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p36 p37

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1063.0, 1043.0
18.0, 18.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1066.0, 910.0
20.0, 20.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
793.0, 729.0
22.0, 22.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p28

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
862.0, 374.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1051.0, 375.0
18.0, 18.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
745.0, 253.0
22.0, 22.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
715.0, 355.0
26.0, 26.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
878.0, 422.0
20.0, 20.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p38

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
852.0, 952.0
24.0, 24.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p29

p31

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
894.0, 570.0
19.0, 19.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
843.0, 651.0
18.0, 18.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
890.0, 470.0
19.0, 19.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
1059.0, 1099.0
18.0, 18.0

LPS

--

MO000042409

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m157177

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
325.0, 381.0
21.0, 21.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p15

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
891.0, 1131.0
42.0, 42.0

IRF-3{p}:IRF-3{p}

--

MO000088437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p30

true true true true

csml-variable:Double

m316590

10

false

infinite

0

unit false false false
TRANSFACT09392
TRANSPATHMO000088437

--

Go back
252.0, 548.0
24.0, 24.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p40

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
527.0, 331.0
17.0, 17.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
164.00156174124325, 153.82023486107224
867.8758113544294, 1569.731774409567

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
335.5, 1390.0
24.533232342359398, 35.90229123272106

L.monocytogenes

--

e10

cso30:c:Cell

cso30:i:CC_Cytoplasm

--

--

p22

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
697.0, 320.0
230.51095139665844, 384.8360798740822

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
1040.0, 469.5
40.64898048673536, 21.00197325147994

ssRNA

--

e12

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p2 p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
898.5, 515.0
18.024994518745885, 34.88708616531462

ssRNA:TLR7

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p37

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
866.5, 605.0
19.302784477088355, 37.360228020171014

ssRNA:TLR8

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p36

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
419.0, 283.0
18.0, 18.0

dsRNA

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p13 p14 p26

true true true true

csml-variable:Double

m15

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1037.0, 654.5
54.68293977182277, 11.84797028389493

CpG DNA

--

e16

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
763.5, 675.0
17.290944968208727, 33.46634509975882

TLR9:CpG DNA

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p35

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
386.5, 353.0
18.682219630061656, 22.876187302116318

DDX58:dsRNA

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p34

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
520.0, 999.0
47.491349480968864, 25.32871972318339

PKZ

--

e19

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p6

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
164.00156174124325, 153.82023486107224
867.8758113544294, 1569.731774409567

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
89.0, 923.0
45.315391084945325, 25.678721614802352

Poly(rI:rC)

--

e20

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
501.0, 530.5
29.836989333869997, 18.399476755886496

DAI

--

e21

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p8 p9 p10 p27

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
266.0, 705.5
60.0, 13.0

Z-DNA

--

e22

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p8 p7

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
354.0, 667.5
60.0, 17.0

DAI:ZDNA

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
285.0, 427.5
22.88, 17.16

ADAR1

--

e24

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
394.0, 483.5
60.0, 17.0

ADAR1:ZDNA

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
572.5, 419.0
15.473133427248944, 25.09156771986315

SmtB

--

e26

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9 p11

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
535.5, 485.0
24.250958173637727, 29.695050824862527

DAI:SmtB

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
561.0, 591.0
14.580916744621142, 33.648269410664184

Mar

--

e28

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10 p12

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
479.5, 660.0
25.581903016163974, 31.324779203466097

DAI:Mar

--

e29

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
181.35907796833152, 175.44188464632805
833.1607789002518, 1526.4884748390568

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
596.0, 370.5
31.74481787079895, 19.575971020326023

ADARs

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11 p12 p13

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
648.5, 513.0
23.98150308281953, 29.36510581569738

SmtB:ADARs

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
624.5, 638.0
22.601566405599062, 27.675387435427428

ADARs:Mar

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
669.5, 268.0
20.282619563406094, 24.835860689885024

ADARs:dsRNA

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
486.5, 384.0
19.988668555240793, 24.475920679886684

dsRNA:IFIH1

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p40

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
252.0, 261.5
40.570050427537815, 20.96119272089454

ssRNA

--

e35

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
243.5, 369.0
24.267288785202467, 29.715047492084658

ssRNA:DDX58

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
623.0, 977.0
41.21107266435986, 21.97923875432526

DLM-1

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p16 p17 p18 p19 p20 p21

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1065.0, 967.0
14.9822263797942, 34.574368568755844

IFN-alpha

--

e38

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p17

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
363.5, 1470.0
24.533232342359398, 35.90229123272106

S.flexneri

--

e39

cso30:c:Cell

cso30:i:CC_Cytoplasm

--

--

p23

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
213.4704829884456, 213.2797717705253
768.9379688600245, 1450.8127005906606

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
435.5, 1530.0
24.533232342359398, 35.90229123272106

enterophathogenic e.coli

--

e40

cso30:c:Cell

cso30:i:CC_Cytoplasm

--

--

p24

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
607.5, 1518.0
24.533232342359398, 35.90229123272106

L.pnemophila

--

e41

cso30:c:Cell

cso30:i:CC_Cytoplasm

--

--

p25

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
542.0, 1180.0
48.78892733564014, 26.020761245674738

Type I IFN

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p22 p23 p24 p25 p39

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
890.0, 861.5
60.0, 13.0

ISD

--

e43

cso30:c:Dna

cso30:i:CC_Cytoplasm

--

--

p20

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
542.0, 769.5
60.0, 13.0

B-DNA

--

e44

cso30:c:Dna

cso30:i:CC_Cytoplasm

--

--

p19 p27

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
337.0, 751.5
22.080000000000002, 16.56

E3L

--

e45

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p26

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
436.5, 774.0
23.148641893017835, 28.345275787368777

E3L:dsRNA

--

e46

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p26

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
662.0, 703.5
60.0, 17.0

DAI:B-DNA

--

e47

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p27 p29

p28

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
855.0, 805.0
18.088235294117652, 30.147058823529413

DAI:B-DNA:IRF-3:TBK1

--

e48

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p28

p29

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
703.0, 1211.0
42.0, 42.0

IRF-3{p}:IRF-3{p}

--

e49

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p32 p33

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
TRANSFACT09392
TRANSPATHMO000088437

--

Go back
697.0, 320.0
230.51095139665844, 384.8360798740822

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
366.710476446995, 856.0826579956365
466.75374978824226, 527.2829639104025

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
417.1233581745891, 868.578497691455
272.924911421803, 511.042215535339

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
372.7947897589461, 863.1203156248317
454.58512316434064, 513.2076486520137

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
373.66397737493884, 864.2030321831685
452.84674793235433, 511.042215535339

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
366.710476446995, 856.0826579956365
466.75374978824226, 527.2829639104025

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
366.710476446995, 856.0826579956365
466.75374978824226, 527.2829639104025

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
373.66397737493884, 864.2030321831685
452.84674793235433, 511.042215535339

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
707.4320219162515, 1072.6259696631512
29.160209706389665, 32.88264452072159

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
630.9435117088676, 1224.206287830414
82.57282351933519, 93.11362401703224

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
366.710476446995, 856.0826579956365
466.75374978824226, 527.2829639104025

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
697.0, 320.0
230.51095139665844, 384.8360798740822

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
476.72170902950256, 1090.4028501824168
14.781405433199788, 8.865363882071641

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
476.22811606211366, 1063.96423719645
50.59327915732855, 113.44009525374695

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
497.45261365982213, 1137.7464129712444
7.897487478217139, 9.837623436639301

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
494.0, 1102.0
51.90311418685121, 27.681660899653977

IFN-alpha

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
351.5, 531.0
24.928794274178756, 34.78436410350523

DDX58:dsRNA:MAVS

--

e64

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p34

p39 p41

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
733.5, 621.0
21.87483942007708, 30.523031748944756

TLr9:CpG DNA:MyD88

--

e65

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
754.5, 494.0
19.77573866764544, 27.594053954854104

ssRNA:TLR8:MyD88

--

e66

cso30:c:Complex

cso30:i:CC_Extracellular

--

p36

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
790.5, 434.0
19.77573866764544, 27.594053954854104

ssRNA:TLR7:MyD88

--

e67

cso30:c:Complex

cso30:i:CC_Extracellular

--

p37

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
440.5, 588.0
22.427234354927517, 31.293815378968624

IFIH1:dsRNA:MAVS

--

e68

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p40

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
284.5, 857.0
23.940676553907682, 29.31511414764206

Atg5:Atg12

--

e69

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

--

p41

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
175.40418403332433, 160.13695961361896
851.1157853834271, 1502.2832585509734

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
398.0, 823.0
20.382352941176475, 33.970588235294116

Atg5:Atg12:DDX58:dsRNA:MAVS

--

e70

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p41

p39

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
178.44488331121272, 186.65080745915594
816.4855146185795, 1476.7818608076368

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
185.553414718915, 215.16465530469304
812.7578103739592, 1457.4142367511959

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
955.0, 375.0
17.0, 17.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18280611,12524386 As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively

Go back
482.0, 598.0
19.0, 19.0

p9

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c29 : 1

m21*m28*0.1

nodelay

--

true

0

false

PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.

Go back
650.0, 442.0
19.0, 19.0

p9

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m26*m30*0.1

nodelay

--

true

0

false

PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.

Go back
602.0, 546.0
19.0, 19.0

p9

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m28*m30*0.1

nodelay

--

true

0

false

PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.

Go back
602.0, 286.0
19.0, 19.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 e15

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m30*m15*0.1

nodelay

--

true

0

false

PMID: 18280611 ADARs bind to ds-RNA through its ds-RNA-binding domains to deaminate adenosine (A) to inosine (I) for RNA editing.

Go back
462.0, 330.0
19.0, 19.0

p5

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e15 MO000103999

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m15*m76904*0.1

nodelay

--

true

0

false

PMID: 18280611 Figure1

Go back
274.0, 322.0
19.0, 19.0

p5

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e35 MO000066987

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m35*m41844*0.1

nodelay

--

true

0

false

PMID: 18280611 Figure1

Go back
673.0, 905.0
21.0, 21.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016665

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m1639*0.1

nodelay

--

true

0

false

PMID: 18280611,10564822 Further study revealed that DLM-1 is upregulated not only in tumor stromal cells but also in macrophages upon stimulation with type II IFN (IFN-gamma).

Go back
721.0, 977.0
21.0, 21.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 18280611,17618271 This gene can also be induced by treatment with type I IFNs (IFN-alpha/beta)

Go back
725.0, 1041.0
21.0, 21.0

p17

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016660

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 18280611,17618271 This gene can also be induced by treatment with type I IFNs (IFN-alpha/beta)

Go back
570.0, 918.0
19.0, 19.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18280611,16413926,10564822 DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)

Go back
955.0, 471.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m19940*m12*0.1

nodelay

--

true

0

false

PMID: 18280611,12524386 As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively

Go back
702.0, 942.0
19.0, 19.0

p19

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 18280611,16413926,10564822 DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)

Go back
726.0, 1094.0
19.0, 19.0

p19

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000042409

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m157177*0.1

nodelay

--

true

0

false

PMID: 18280611,16413926,10564822 DAI (DLM-1/ZBP1) mRNA expression is also regulated by signaling triggered by PAMPs such as B-form DNA (B-DNA), IFN-stimulatory DNA (ISD) and lipopolysaccharides (LPS)

Go back
482.0, 1242.0
19.0, 19.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e10

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m10*0.1

nodelay

--

true

0

false

PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila

Go back
510.0, 1278.0
19.0, 19.0

p22

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e39

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila

Go back
554.0, 1318.0
19.0, 19.0

p22

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e40

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m40*0.1

nodelay

--

true

0

false

PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila

Go back
610.0, 1314.0
19.0, 19.0

p22

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 18280611,12359878,3295042,16413926 Type I IFN activation can be evoked by intracellular infection by several bacteria, including L. monocytogenes,S. flexneri, enterophathogenic E. coli and L. pneumophila

Go back
418.0, 702.0
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e15 e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m15*m45*0.1

nodelay

--

true

0

false

PMID: 18280611 E3L also contains a double-stranded RNA binding domain at the C-terminus.

Go back
561.0, 701.0
21.0, 21.0

p27

p27

cso30:i:ME_DNABinding

cso30:i:CC_Cytoplasm

--

e44 e21

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m44*m21*0.1

nodelay

--

true

0

false

PMID: 18280611

Go back
682.0, 810.0
19.0, 19.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019331 MO000007694 e47

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m3902*m977*m47*0.1

nodelay

--

true

0

false

PMID: 18280611,16286919 IRF-3 is activated by B-DNA through the TBK1- and IKKi-dependent signaling pathway PMID: 18280611 Figue 2 PMID: 18280611,17618271 Moreover, DAI (DLM-1/ZBP1) associates with both TBK1 and IRF-3 in a ligand-dependent manner

Go back
829.0, 869.0
21.0, 21.0

p29

p29

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

e48

MO000041456 e47 MO000019331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 2

Go back
954.0, 570.0
19.0, 19.0

p1

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e12

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m19823*m12*0.1

nodelay

--

true

0

false

PMID: 18280611,12524386 As for RNA recognition, TLR3 and TLR7/8 detect double-stranded RNA (ds-RNA) and single-stranded RNA (ss-RNA), respectively

Go back
835.0, 1203.0
21.0, 21.0

p30

p30

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

MO000088437

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m316590*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 2

Go back
853.0, 1021.0
21.0, 21.0

p31

p31

cso30:i:ME_Dimerization

cso30:i:CC_Cytoplasm

--

MO000041456

MO000088437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m19324*0.1

nodelay

--

true

0

false

--

Go back
606.0, 1158.0
22.0, 22.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 2

Go back
653.0, 1129.0
22.0, 22.0

p32

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e49

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 2

Go back
385.0, 421.0
21.0, 21.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e18 MO000094908

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m18*m68199*0.1

nodelay

--

true

0

false

PMID: 18280611 Figure 1

Go back
858.0, 710.0
19.0, 19.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e17 MO000016573

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m17*m1572*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 1

Go back
778.0, 602.0
19.0, 19.0

p35

p36

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016573 e14

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m1572*m14*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 1

Go back
798.0, 546.0
19.0, 19.0

p35

p37

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016573 e13

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m1572*m13*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 1

Go back
778.0, 370.0
19.0, 19.0

p35

p38

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18280611 Figue 1

Go back
437.0, 985.0
23.0, 23.0

p39

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e64 e70

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c110 : 1
stoichiometry:c106 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18280611,17709747 However, the Atg5?Atg12 conjugate, a key component of the autophagic machinery, interacts with the cytosolic RNA sensor RIG-I and its adaptor IFN-¦Â promoter stimulator 1 (IPS-1), resulting in the inhibition of the type I IFN production pathway

Go back
922.0, 650.0
19.0, 19.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19828*m16*0.1

nodelay

--

true

0

false

PMID: 18280611 On the other hand, TLR9 recognizes specific DNA sequences that contain unmethylated CpG motifs, which are commonly found in the genomes of infectious bacteria and viruses.

Go back
441.0, 441.0
21.0, 21.0

p34

p40

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e34 MO000094908

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m34*m68199*0.1

nodelay

--

true

0

false

PMID: 18280611 Figure 1

Go back
285.0, 777.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e64 e69

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m64*m69*0.1

nodelay

--

true

0

false

PMID: 18280611,17709747 However, the Atg5?Atg12 conjugate, a key component of the autophagic machinery, interacts with the cytosolic RNA sensor RIG-I and its adaptor IFN-¦Â promoter stimulator 1 (IPS-1), resulting in the inhibition of the type I IFN production pathway

Go back
326.0, 286.0
19.0, 19.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e15

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m41844*m15*0.1

nodelay

--

true

0

false

PMID: 18280611 Figure1

Go back
522.0, 926.0
19.0, 19.0

p6

p6

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18280611,15659550 PKZ is constitutively expressed at low levels and is highly induced in response to stimulation with poly(rI:rC), which mimics viral ds-RNA

Go back
286.0, 482.0
19.0, 19.0

p8

p7

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

e22 e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m22*m24*0.1

nodelay

--

true

0

false

PMID: 18280611,11524677,10364558 Further study by Rich's group provided a structural basis of the Zalpha domain of DLM-1 or ADAR1 to interact with characteristic features of the left-handed helical Z-DNA backbone

Go back
318.0, 598.0
19.0, 19.0

p8

p8

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

e22 e21

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m22*m21*0.1

nodelay

--

true

0

false

PMID: 18280611,11524677,10364558 Further study by Rich's group provided a structural basis of the Zalpha domain of DLM-1 or ADAR1 to interact with characteristic features of the left-handed helical Z-DNA backbone

Go back
478.0, 422.0
19.0, 19.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 e21

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c24 : 1
stoichiometry:c26 : 1

m26*m21*0.1

nodelay

--

true

0

false

PMID: 18280611 It is quite interesting to presume that these bacterial proteins such as SmtB and MarR might interact with DAI (DLM-1/ZBP1) or ADARs through the Zbeta domain.

Go back
880.0, 383.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 660.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
465.9509778128281, 408.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 461.99171555893554

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.0, 462.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.0, 566.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
759.0, 275.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
748.8605619655765, 372.4871333448388

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.0, 1008.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.1881340053539, 566.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 806.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 793.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
949.0, 660.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.0, 857.0

c110

c110

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
788.8467785250012, 662.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 313.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.98833818622006, 292.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 305.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
134.0, 936.0

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
533.0, 945.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.0, 624.6554714273235

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.51298281696256, 545.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
980.0, 384.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
335.0, 617.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
296.0, 509.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 445.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.0, 492.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.9807861400872, 448.75090228729783

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
505.0, 432.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
496.0, 441.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.622181616751, 549.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 608.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 617.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.7639112242477, 390.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 434.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 390.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 461.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
576.0, 571.1754418849364

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 390.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.0, 565.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 313.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.0, 292.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.0, 283.90294983503406

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 301.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.0, 480.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
489.0, 340.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 349.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 282.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.2680368629481, 347.020613557655

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.77777130012333, 341.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
653.8500704975418, 926.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.9995375588886, 916.0860165328912

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
749.999386626541, 984.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
672.0, 988.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.0, 1052.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.9990818844292, 480.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
666.5775375331502, 1003.5536798306425

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 783.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.0, 936.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.4306105334065, 875.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
671.0793457790559, 957.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.9993509654379, 1104.1019025600692

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
657.9571543086322, 1005.2790621242674

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
360.0, 1266.8717032516947

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
501.0, 1210.981966459253

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 1303.4795369723442

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
922.9619305082008, 490.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
525.0, 1213.194942833106

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
457.0, 1344.072975806437

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
564.0, 1213.9987247947636

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 1341.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
574.0769230769231, 1213.3846153846155

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 301.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
359.0, 722.0816153065192

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
430.0, 721.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
572.0, 730.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.0, 549.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
913.0, 580.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
582.0, 712.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
707.5003060050375, 748.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 780.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 721.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
701.0, 820.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.0459984420344, 835.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 890.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
704.3023375084848, 726.9904271088225

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.9711902327327, 758.753348248749

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
864.0, 976.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.54774877087, 491.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.0, 1042.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
861.8207152494824, 1172.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
752.9178268547516, 1216.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.9001992461299, 1180.0481168910628

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.0363475688873, 1133.806548684808

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.3599068047633, 1157.7075489304052

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.8255999415425, 1103.48291759204

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.0, 376.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 447.55114592832746

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
371.0828999980854, 442.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
893.1554175279994, 585.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 695.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0115218004042, 733.2784093857208

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.6464582024041, 648.4524817084066

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
801.2831019843318, 627.0073982241191

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.9195959492894, 614.1313708498985

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.8485794463671, 529.7834924057565

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.9271281140216, 571.9697679140744

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.7721627102651, 534.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
801.5699763999032, 469.9796695986459

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
804.1020362515915, 388.68253731564

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back