1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18304834.csml convertedTime:2009.07.01.11:16

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title LPS/TLR4 signal transduction pathway.
Authors Lu YC, Yeh WC, Ohashi PS.
Affiliation The Campbell Family Institute for Breast Cancer Research, Ontario CancerInstitute, 610 University Avenue, Toronto, Ont., Canada M5G 2M9.
Abstract The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS)induces the release of critical proinflammatory cytokines that are necessary toactivate potent immune responses. LPS/TLR4 signaling has been intensivelystudied in the past few years. Here we review molecules involved inTLR4-mediated signaling, including players that are involved in the negativeregulation of this important pathway.
PMID 18304834
Model Abstract

Entity

MO000000058:NF-kappaB{active} MO000000077:MAPKs MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000248:IKK MO000000276:AP-1 MO000007694:IRF-3 MO000016569:IRAK-M MO000016573:MyD88 MO000016574:TAK1 MO000016599:IKK-gamma MO000016653:RP105 MO000016882:LPS MO000016962:TRAF1 MO000016963:TRAF3 MO000016964:TRAF4 MO000017004:SOCS-1 MO000018132:CD14 MO000019326:TANK MO000019331:TBK1 MO000019394:TLR4 MO000019397:TLR2 MO000019398:TLR3 MO000019420:LBP MO000019422:TLR6 MO000021928:LPS:LBP MO000021929:LPS:LBP:CD14 MO000022131:MD-2 MO000022136:Ubc13 MO000022200:MD-1 MO000022224:dsRNA MO000022528:TIRAP MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 MO000044794:ST2L MO000066718:SIGIRR e10:degradants e11:TLR9:CpGDNA e12:ssRNA e13:TLR7:ssRNA e14:TLR8:ssRNA e15:TLR4:MD-2:LPS:LBP:CD14 e16:F protein e17:TLR4:F protein e18:Envelope protein e19:TLR4:envelope protein e20:TLR4:MD-2 e21:TLR4:LPS oligomer e22:TLR4:LPS oligomer:TIRAP e23:TLR4:LPS oligomer:TIRAP:MyD88 e24:TLR4:LPS:TIRAP:MyD88:IRAK-4{active} e25:IRAK1 e26:TLR4:LPS:TIRAP:MyD88:IRAK-4{active}:IRAK1{active} e27:TRAF6{active} e28:TLR4:LPS:TIRAP:MyD88:IRAK-4{active] e29:IRAK1 degradants e30:UVE1A e31:TRAF6{active}:Ubc13:UVE1A e32:TAK1{active} e33:IKK{active} e34:MAPKs{active} e35:NF-KappaB:IKappaB e36:NF-KappaB:IKappaB{p} e37:degradants e38:NF-kappaB e39:proinflammatory cytokines e40:AP-1{active} e41:LPS:TLR4:TRAM e42:LPS:TLR4:TRAM:TRIF e43:RIP1 e44:LPS:TLR4:TRAM:TRIF:RIP1 e45:LPS:TLR4:TRAM:TRIF:TRAF3 e46:Ikki e47:LPS:TLR4:TRAM:TRIF:TRAF3:TANK:IKKi:TBK1 e48:IRF-3{active} e49:IRF3:IRF3 e5:TLR2:TLR6 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:LTA e60: e61: e62: e63:IRF3:IRF3 e64:Type I interferons e65:RP105:MD-1 e66:TLR4:MD-2:RP105:MD-1 e67:ST2L:MyD88 e68:ST2L:TIRAP e69:TRIAD3A e7:TLR2:TLR6:LTA e70:TRIAD3A:RIP1 e71:TRIAD3A:TRIF e72:TRIAD3A:TIRAP e73:NF-kappaB e74:TIRAP{ub} e75:caspases e76:TRIF:TRAF4 e77:TRAF1cleaved fragments e78:TRAF4:TRAF6 e79: e8:TLR2:TLR6:PGN e80: e81: e82: e83: e84: e85: e86: e9:CpGDNA

Process

p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p7 p8 p9
Model Detail
565.0, 889.0
22.0, 22.0

NF-kappaB{active}

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27 p54

p28

true true true true

csml-variable:Double

m38

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
405.0, 1261.0
22.0, 22.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p41

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
459.0, 1111.0
18.0, 18.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
451.0, 1055.0
18.0, 18.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
740.0, 1036.0
24.0, 24.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p60

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
534.0, 1070.0
20.0, 20.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p24 p42

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
273.0, 1141.0
22.0, 22.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
265.0, 489.0
29.5, 29.5

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
341.0, 985.0
22.0, 22.0

IRAK-M

--

MO000016569

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p57

true true true true

csml-variable:Double

m1571

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016569

--

Go back
891.0, 787.0
25.0, 25.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p45

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
733.0, 1189.0
30.0, 30.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
476.0, 1168.0
16.0, 16.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
176.0, 480.0
23.5, 23.5

RP105

--

MO000016653

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m1632

10

false

infinite

0

unit false false false
InterProIPR000483
TRANSPATHMO000016653

--

Go back
1198.0, 226.0
20.0, 20.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
409.0, 197.0
22.0, 22.0

TRAF1

--

MO000016962

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58

true true true true

csml-variable:Double

m1871

10

false

infinite

0

unit false false false
InterProIPR002083
TRANSPATHMO000016962

--

Go back
729.0, 361.0
22.0, 22.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
342.0, 346.0
20.0, 20.0

TRAF4

--

MO000016964

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p60

true true true true

csml-variable:Double

m1873

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016964

--

Go back
389.0, 401.0
22.0, 22.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
1086.0, 282.0
20.0, 20.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
266.0, 278.0
20.0, 20.0

TANK

--

MO000019326

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m3897

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000019326

--

Go back
313.0, 389.0
22.0, 22.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
977.0, 325.0
21.5, 21.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10 p12 p50

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
284.0, 116.0
23.0, 23.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
972.0, 200.0
23.0, 23.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
1138.0, 286.0
20.0, 20.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
340.0, 112.0
23.0, 23.0

TLR6

--

MO000019422

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m3987

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019422

--

Go back
1197.0, 337.0
22.0, 22.0

LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p11

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
1179.0, 387.0
25.0, 25.0

LPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p13

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
971.0, 395.0
26.5, 26.5

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
662.0, 1074.0
20.0, 20.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
180.0, 536.0
24.0, 24.0

MD-1

--

MO000022200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43

true true true true

csml-variable:Double

m6500

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022200

--

Go back
971.0, 287.0
25.0, 25.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
913.0, 701.0
21.5, 21.5

TIRAP

--

MO000022528

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p46 p49 p51 p55

true true true true

csml-variable:Double

m6810

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000022528

--

Go back
925.0, 861.0
21.5, 21.5

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
913.0, 309.0
22.0, 22.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p48 p52 p58 p59

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
853.0, 441.0
21.0, 21.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
967.0, 247.0
26.0, 26.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
716.0, 108.0
24.0, 24.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
507.0, 111.0
25.0, 25.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
176.0, 48.0
23.0, 23.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
613.0, 113.0
21.0, 21.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
179.0, 651.0
26.0, 26.0

ST2L

--

MO000044794

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45 p46

true true true true

csml-variable:Double

m22464

10

false

infinite

0

unit false false false
TRANSPATHMO000044794

--

Go back
177.0, 869.0
22.0, 22.0

SIGIRR

--

MO000066718

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m41575

10

false

infinite

0

unit false false false
TRANSPATHMO000066718

--

Go back
972.0, 364.0
24.141298104537626, 23.3365881677197

degradants

--

e10

cso30:c:EntityBiological

cso30:i:CC_Nucleoplasm

--

p50

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
566.5, 109.0
19.928085946064456, 38.570488927866705

TLR9:CpGDNA

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
767.0, 49.5
42.253891690418776, 21.83117737338303

ssRNA

--

e12

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p5 p7

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
673.5, 104.0
20.15237886428415, 39.00460425345319

TLR7:ssRNA

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
818.5, 101.0
19.608638456478843, 37.9522034641526

TLR8:ssRNA

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

p35

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
982.5, 614.0
18.704670028502523, 36.20258715194037

TLR4:MD-2:LPS:LBP:CD14

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1161.0, 474.5
29.84906419802776, 18.40692292211713

F protein

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
974.5, 469.0
19.608638456478843, 37.9522034641526

TLR4:F protein

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1123.5, 558.0
16.93258200845241, 27.45824109478769

Envelope protein

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p10

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
970.5, 558.0
18.956149967112474, 36.68932251699189

TLR4:envelope protein

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
971.0, 425.0
26.950276243093914, 29.94475138121547

TLR4:MD-2

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p13 p44

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
978.0, 671.0
20.823529411764703, 34.705882352941174

TLR4:LPS oligomer

--

e21

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p15 p32

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
970.0, 747.0
20.294117647058826, 33.82352941176472

TLR4:LPS oligomer:TIRAP

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
976.0, 828.0
23.64705882352942, 39.41176470588236

TLR4:LPS oligomer:TIRAP:MyD88

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p17

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
964.0, 904.0
23.91176470588236, 39.8529411764706

TLR4:LPS:TIRAP:MyD88:IRAK-4{active}

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17 p57

p18

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
853.0, 963.5
22.559999999999995, 16.919999999999998

IRAK1

--

e25

cso30:c:Protein

cso30:i:CC_Cytosol

--

p57

p18 p20

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
974.0, 1004.0
19.235294117647058, 32.05882352941177

TLR4:LPS:TIRAP:MyD88:IRAK-4{active}:IRAK1{active}

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19 p57

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
772.0, 1072.0
24.0, 24.0

TRAF6{active}

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

p21

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
977.0, 1101.0
22.764705882352946, 37.94117647058824

TLR4:LPS:TIRAP:MyD88:IRAK-4{active]

--

e28

cso30:c:Complex

cso30:i:CC_Extracellular

--

p20

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
873.0, 1133.0
22.004595060310162, 21.271108558299822

IRAK1 degradants

--

e29

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p20

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
767.0, 1148.5
25.924733346749846, 15.986918897162411

UVE1A

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
680.5, 1140.0
22.97962928977795, 32.06459900899249

TRAF6{active}:Ubc13:UVE1A

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p22

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
609.0, 1237.0
30.0, 30.0

TAK1{active}

--

e32

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

p24 p25

true true true true

csml-variable:Double

m32

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
602.0, 1038.0
20.0, 20.0

IKK{active}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p24 p42

p26

true true true true

csml-variable:Double

m33

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
421.0, 1197.0
22.0, 22.0

MAPKs{active}

--

e34

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25 p41

p30

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
536.0, 951.0
23.2707182320442, 25.85635359116023

NF-KappaB:IKappaB

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p26

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
686.0, 953.0
19.690607734806644, 21.878453038674046

NF-KappaB:IKappaB{p}

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p27

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
792.0, 944.0
16.335439402642166, 15.790924755887426

degradants

--

e37

cso30:c:EntityBiological

cso30:i:CC_Cytosol

--

p27 p51 p52 p53 p56

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
665.0, 729.0
22.0, 22.0

NF-kappaB

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p29

true true true true

csml-variable:Double

m39

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
587.0, 580.5
42.26487523992322, 23.245681381957777

proinflammatory cytokines

--

e39

cso30:c:Rna

cso30:i:CC_Nucleoplasm

--

p29 p31

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
361.0, 1045.0
22.0, 22.0

AP-1{active}

--

e40

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p31

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
974.5, 154.0
19.64947696825106, 27.417874839420087

LPS:TLR4:TRAM

--

e41

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
950.0, 107.0
20.911764705882362, 34.852941176470594

LPS:TLR4:TRAM:TRIF

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33

p34

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
662.0, 173.0
12.81758652946679, 29.579045837231057

RIP1

--

e43

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34 p47 p53

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
182.0, 248.0
19.764705882352942, 32.94117647058823

LPS:TLR4:TRAM:TRIF:RIP1

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p41 p42

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
183.0, 309.0
17.735294117647065, 29.55882352941176

LPS:TLR4:TRAM:TRIF:TRAF3

--

e45

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p35

p36

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
323.0, 282.5
25.440000000000005, 19.08

Ikki

--

e46

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p36

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
181.0, 390.0
21.705882352941174, 36.1764705882353

LPS:TLR4:TRAM:TRIF:TRAF3:TANK:IKKi:TBK1

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
305.0, 549.0
29.5, 29.5

IRF-3{active}

--

e48

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37

p38

true true true true

csml-variable:Double

m49

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
286.5, 817.0
18.19230128311948, 22.276287285452426

IRF3:IRF3

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
420.0, 115.0
23.668508287292813, 26.29834254143647

TLR2:TLR6

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

p2 p3

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
385.89664115630075, 379.5401854861114
451.3477959728878, 409.3228615247612

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
434.64556511612835, 389.24054224240643
263.9165883342398, 396.71538119032306

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
391.78013197903846, 385.00342696436803
439.58081432741255, 398.396378568248

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
392.62063066800124, 385.84392565333053
437.8998169494872, 396.71538119032306

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
385.89664115630075, 379.5401854861114
451.3477959728878, 409.3228615247612

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
385.89664115630075, 379.5401854861114
451.3477959728878, 409.3228615247612

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
392.62063066800124, 389.4747177730269
437.8998169494872, 396.71538119032306

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
715.3721272296192, 547.6399232786207
28.197730360082332, 25.526366431232486

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
641.408242600915, 665.3097397333779
79.84737545144196, 72.28288725077921

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
385.89664115630075, 379.5401854861114
451.3477959728878, 409.3228615247612

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
538.0, 40.0
43.62489486963834, 24.72077375946173

LTA

--

e6

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
492.2767771078644, 561.4398828850665
14.293521512538792, 6.882065913444618

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
491.7994759655817, 540.915933766921
48.923367083952044, 88.06206075111376

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
512.3234250837278, 598.1920708408161
7.636818276519333, 7.636818276519345

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
486.5, 641.0
18.77203799366772, 22.986168971838026

IRF3:IRF3

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p40

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
551.0, 457.0
42.40484429065744, 22.615916955017298

Type I interferons

--

e64

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p40

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
180.5, 590.0
22.55257457090484, 27.615397433761036

RP105:MD-1

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
974.0, 516.0
19.67647058823529, 32.79411764705882

TLR4:MD-2:RP105:MD-1

--

e66

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p44

p13

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
179.5, 724.0
25.884019330111645, 31.694717547075484

ST2L:MyD88

--

e67

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p45

p16

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
183.5, 788.0
25.884019330111645, 31.694717547075484

ST2L:TIRAP

--

e68

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p46

p15

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
640.5, 279.0
15.785872408935399, 25.598712014489838

TRIAD3A

--

e69

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

--

p47 p48 p49 p50 p51 p52 p53 p54

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
466.5, 105.0
19.703793027844767, 38.1363736022802

TLR2:TLR6:LTA

--

e7

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
566.5, 185.0
18.633227795367432, 22.816197300449925

TRIAD3A:RIP1

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
834.5, 201.0
18.633227795367432, 22.816197300449925

TRIAD3A:TRIF

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
550.5, 281.0
18.633227795367432, 22.816197300449925

TRIAD3A:TIRAP

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
489.0, 913.0
22.0, 22.0

NF-kappaB

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
685.0, 804.0
30.18894331700489, 23.144856543037086

TIRAP{ub}

--

e74

cso30:c:Protein

cso30:i:CC_Extracellular

--

p55

p56

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
357.0, 224.0
13.449953227315246, 31.03835360149673

caspases

--

e75

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
426.5, 380.0
18.984335944009327, 23.24612564572572

TRIF:TRAF4

--

e76

cso30:c:Complex

cso30:i:CC_Extracellular

--

p59

p54

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
495.0, 287.5
25.960957939223185, 16.0092573958543

TRAF1cleaved fragments

--

e77

cso30:c:Protein

cso30:i:CC_Extracellular

--

p58

p37 p42

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
349.5, 479.0
20.58473587735378, 25.205799033494426

TRAF4:TRAF6

--

e78

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p60

p54

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
155.75, 93.99690800911759
856.2594311764528, 1243.2886940682085

--

e79

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false true false

--

Go back
177.5, 131.0
21.967112475334353, 42.51699188774392

TLR2:TLR6:PGN

--

e8

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false false false

--

Go back
204.5567875770579, 141.0911767238224
758.6458560223374, 1149.1001566387988

--

e80

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false true false

--

Go back
155.75, 93.99690800911759
856.2594311764528, 1243.2886940682085

--

e81

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false true false

--

Go back
172.87518862352908, 111.12209663264673
822.0090539293948, 1209.0383168211513

--

e82

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false true false

--

Go back
167.0, 99.0
839.7237354966342, 1189.8668429177399

--

e83

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false true false

--

Go back
164.0, 113.0
829.9775981223105, 1167.545103664102

--

e84

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false true false

--

Go back
170.0, 120.0
805.5569854171277, 1169.6687428256696

--

e85

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false true false

--

Go back
178.0, 141.0
801.8791759029863, 1154.3288303559784

--

e86

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false true false

--

Go back
637.0, 62.5
53.85513398779518, 11.668612364022286

CpGDNA

--

e9

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false false false

--

Go back
1062.0, 562.0
20.0, 20.0

p8

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e18 MO000019394

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m18*m3961*0.1

nodelay

--

true

0

false

PMID: 1830483,11854525,11062499 Evidence suggests that several PAMPs can stimulate TLR4. These molecules include lipopolysaccharide (LPS) from Gram-negative bacteria, fusion (F) protein from respiratory syncytial virus (RSV) and the envelope protein from mouse mammary tumor virus (MMTV)

Go back
1121.0, 337.0
21.0, 21.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c31 : 1
stoichiometry:c32 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 1830483,2427635,2477488 LBP is a soluble shuttle protein which directly binds to LPS and facilitates the association between LPS and CD14

Go back
1065.0, 329.0
22.0, 22.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000022131

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c36 : 1

m3961*m6438*0.1

nodelay

--

true

0

false

PMID: 1830483,1698311 CD14 facilitates the transfer of LPS to the TLR4/MD-2 receptor complex and modulates LPS recognition

Go back
1093.0, 389.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021929 e20 e66

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c130 : 1
stoichiometry:c39 : 1

m6255*m20*0.1

nodelay

--

true

0

false

PMID: 1830483,1698311 CD14 facilitates the transfer of LPS to the TLR4/MD-2 receptor complex and modulates LPS recognition PMID: 18304834 By interacting with TLR4/MD-2 directly, RP105/MD-1 can inhibit the association between LPS and TLR4/MD-2.

Go back
1053.0, 665.0
22.0, 22.0

p14

p14

cso30:i:ME_Oligomerization

cso30:i:CC_Cytosol

--

e15

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m15*0.1

nodelay

--

true

0

false

PMID: 1830483 Upon LPS recognition, TLR4 undergoes oligomerization and recruits its downstream adaptors through interactions with the TIR (Toll-interleukin-1 receptor) domains.

Go back
1058.0, 726.0
19.0, 19.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000022528 e68

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c137 : 1
stoichiometry:c44 : 1

m21*m6810*0.1

nodelay

--

true

0

false

PMID: 1830483,16751103 TIRAP then facilitates the association between MyD88 and the TLR4 cytoplasmic domain to initiate MyD88-dependent downstream signaling PMID:18304834 ST2L can interact with MyD88 and TIRAP and inhibit their function by sequestration, thereby preventing recruitment to TLR4.

Go back
1074.0, 786.0
19.0, 19.0

p15

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e22 MO000016573 e67 MO000066718

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c138 : 1
stoichiometry:c139 : 1
stoichiometry:c47 : 1

m22*m1572*0.1

nodelay

--

true

0

false

PMID: 1830483,16751103 TIRAP then facilitates the association between MyD88 and the TLR4 cytoplasmic domain to initiate MyD88-dependent downstream signaling PMID: 1830483,15866876 Another IL-1R homolog, SIGIRR, inhibits TLR4¡Çs interaction with MyD88 through the TIR domain of SIGIRR PMID:18304834 ST2L can interact with MyD88 and TIRAP and inhibit their function by sequestration, thereby preventing recruitment to TLR4.

Go back
1061.0, 861.0
21.0, 21.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000039077

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m23*m17258*0.1

nodelay

--

true

0

false

PMID: 1830483 . Upon LPS stimulation, MyD88 recruits and activates a death domain-containing kinase, IL-1 receptor-associated kinase-4 (IRAK-4)

Go back
1065.0, 957.0
21.0, 21.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m24*m25*0.1

nodelay

--

true

0

false

PMID: 1830483,15292196 Biochemical evidence also suggests that IRAK-4 is responsible for the subsequent recruitment, activation and degradation of IRAK-1

Go back
855.0, 1063.0
18.0, 18.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c2 : 1
stoichiometry:c57 : 1

m183*m26*0.1

nodelay

--

true

0

false

PMID: 1830483 Another adaptor protein TRAF6 (TNF receptor-associated factor 6), is critical for the MyD88-dependent pathway downstream of IRAK4 and IRAK1

Go back
476.0, 40.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 e6

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m6*0.1

nodelay

--

true

0

false

PMID: 18304834 For example, the TLR2/TLR6 heterodimer can be stimulated by several bacterial components, such as lipoteichoic acid (LTA) and peptidoglycan (PGN)

Go back
917.0, 1137.0
21.0, 21.0

p20

p20

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e25

e28 e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m25*0.1

nodelay

--

true

0

false

PMID: 1830483,15292196 Biochemical evidence also suggests that IRAK-4 is responsible for the subsequent recruitment, activation and degradation of IRAK-1

Go back
710.0, 1086.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e27 MO000022136 e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m27*m6443*m30*0.1

nodelay

--

true

0

false

PMID: 1830483, TRAF6 forms a complex with UBC13 (ubiquitin-conjugating enzyme 13) and UEV1A (ubiquitin-conjugating enzyme E2 variant 1 isoform A), and activates TAK1 (transforming growth factor-¦Â-activated kinase 1)

Go back
684.0, 1240.0
24.0, 24.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 MO000016574

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m31*m1573*0.1

nodelay

--

true

0

false

PMID: 1830483, TRAF6 forms a complex with UBC13 (ubiquitin-conjugating enzyme 13) and UEV1A (ubiquitin-conjugating enzyme E2 variant 1 isoform A), and activates TAK1 (transforming growth factor-¦Â-activated kinase 1)

Go back
534.0, 1166.0
19.0, 19.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000211 MO000000210 MO000016599

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m182*m181*m1593*0.1

nodelay

--

true

0

false

PMID: 1830483 TAK1 then activates downstream IKK (I¦ÊB kinase) and MAPK (mitogen-activated protein kinase) pathways PMID: 1830483 IKKalpha, IKK¦Â and IKK¦Ã form a complex and phosphorylate I¦ÊB (inhibitor of ¦Ê light chain gene enhancer in B cells) proteins

Go back
594.0, 1170.0
19.0, 19.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000000248

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m32*m207*0.1

nodelay

--

true

0

false

PMID: 1830483 TAK1 then activates downstream IKK (I¦ÊB kinase) and MAPK (mitogen-activated protein kinase) pathways

Go back
502.0, 1242.0
20.0, 20.0

p24

p25

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e32 MO000000077

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m32*m69*0.1

nodelay

--

true

0

false

PMID: 1830483 TAK1 then activates downstream IKK (I¦ÊB kinase) and MAPK (mitogen-activated protein kinase) pathways

Go back
601.0, 953.0
21.0, 21.0

p26

p26

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e35 e33

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m35*m33*0.1

nodelay

--

true

0

false

PMID: 18304834 This phosphorylation leads to the degradation of I¦ÊB proteins and the subsequent translocation of the transcription factor NF-¦ÊB, which controls the expression of proinflammatory cytokines, in addition to other immune related genes. PMID: 18304834 TRIF induces the cleavage of TRAF1 by caspases (likely caspase-8) and the cleaved fragment of TRAF1 can inhibit TRIF-induced NF-¦ÊB and IRF3 activation

Go back
661.0, 877.0
22.0, 22.0

p27

p27

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e36

e37 MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m36*0.1

nodelay

--

true

0

false

PMID: 1830483 This phosphorylation leads to the degradation of I¦ÊB proteins and the subsequent translocation of the transcription factor NF-¦ÊB, which controls the expression of proinflammatory cytokines, in addition to other immune related genes.

Go back
650.0, 846.0
19.0, 19.0

p28

p28

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000000058

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m38*0.1

nodelay

--

true

0

false

PMID: 1830483 This phosphorylation leads to the degradation of I¦ÊB proteins and the subsequent translocation of the transcription factor NF-¦ÊB, which controls the expression of proinflammatory cytokines, in addition to other immune related genes.

Go back
681.0, 629.0
21.0, 21.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1

m39*0.1

nodelay

--

true

0

false

PMID: 1830483 This phosphorylation leads to the degradation of I¦ÊB proteins and the subsequent translocation of the transcription factor NF-¦ÊB, which controls the expression of proinflammatory cytokines, in addition to other immune related genes.

Go back
252.0, 52.0
23.0, 23.0

p2

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042032 e5

e8

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m155701*m5*0.1

nodelay

--

true

0

false

PMID: 18304834 For example, the TLR2/TLR6 heterodimer can be stimulated by several bacterial components, such as lipoteichoic acid (LTA) and peptidoglycan (PGN)

Go back
345.0, 1141.0
21.0, 21.0

p30

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000000276

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m34*m219*0.1

nodelay

--

true

0

false

PMID: 1830483 Activation of the downstream MAPK pathways leads to the induction of another transcription factor AP-1

Go back
562.0, 706.0
19.0, 19.0

p31

p31

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e40

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m41*0.1

nodelay

--

true

0

false

PMID: 1830483 Activation of the downstream MAPK pathways leads to the induction of another transcription factor AP-1,which also has a role in the expression of proinflammatory cytokines

Go back
853.0, 345.0
21.0, 21.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000041132

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1
stoichiometry:c94 : 1

m21*m19005*0.1

nodelay

--

true

0

false

PMID: 1830483 TRIF is an important TIR-containing adaptor protein that mediates MyD88-independent signaling

Go back
841.0, 249.0
21.0, 21.0

p32

p33

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e41 MO000041125

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m42*m18998*0.1

nodelay

--

true

0

false

PMID: 1830483 TRIF is an important TIR-containing adaptor protein that mediates MyD88-independent signaling

Go back
626.0, 246.0
19.0, 19.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 e42

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m44*m43*0.1

nodelay

--

true

0

false

PMID: 18304834 The C-terminal region of TRIF, which contains a Rip homotypic interaction motif (RHIM), mediates the interaction with RIP1 (receptor-interacting protein 1).

Go back
653.0, 341.0
21.0, 21.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e14

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m1872*m14*0.1

nodelay

--

true

0

false

PMID: 1830483 Experiments suggest that TRIF recruits TRAF3 to activate IRF3, and accordingly the induction of Type I interferons was defective in TRAF3-deficient cells

Go back
273.0, 341.0
21.0, 21.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019326 e46 MO000019331 e45

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m3897*m47*m3902*m46*0.1

nodelay

--

true

0

false

PMID: 18304834,16306936,17327220 TRAF3 can associate with TANK (TRAF family member-associated NF-¦ÊB activator), TBK1 (TANK binding kinase 1) and IKKi to mediate downstream signaling

Go back
309.0, 425.0
21.0, 21.0

p37

p37

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e47 MO000007694 e77

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c176 : 1
stoichiometry:c111 : 1

m48*m977*0.1

nodelay

--

true

0

false

PMID: 18304834,12692549,15210742 Experiments suggest that TRIF recruits TRAF3 to activate IRF3, and accordingly the induction of Type I interferons was defective in TRAF3-deficient cells PMID: 18304834 TRIF induces the cleavage of TRAF1 by caspases (likely caspase-8) and the cleaved fragment of TRAF1 can inhibit TRIF-induced NF-¦ÊB and IRF3 activation

Go back
308.0, 648.0
23.0, 23.0

p38

p38

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18304834,12692549,15210742 TBK1 and IKKi are important for the dimerization and translocation of IRF3

Go back
400.0, 816.0
23.0, 23.0

p39

p39

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 18304834,12692549,15210742 TBK1 and IKKi are important for the dimerization and translocation of IRF3

Go back
597.0, 29.0
21.0, 21.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e9

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19828*m9*0.1

nodelay

--

true

0

false

PMID: 18304834 Viral DNA is rich in unmethylated CpG motifs, which stimulates TLR9

Go back
500.0, 536.0
23.0, 23.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18304834,16006187,16932750 IRF3, together with NF-¦ÊB, activates the transcription of target genes, such as Type I interferons

Go back
249.0, 949.0
22.0, 22.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 MO000000077

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m45*m69*0.1

nodelay

--

true

0

false

PMID: 18304834 TRIF signals the induction of Type I interferons by recruiting TRAF3 and RIP1 to activate transcription factor IRF3, as well as NF-KappaB and AP-1.

Go back
329.0, 921.0
22.0, 22.0

p41

p42

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 MO000000248 e77

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c122 : 1
stoichiometry:c3 : 1
stoichiometry:c123 : 1

m45*m207*0.1

nodelay

--

true

0

false

PMID: 18304834 TRIF signals the induction of Type I interferons by recruiting TRAF3 and RIP1 to activate transcription factor IRF3, as well as NF-KappaB and AP-1.

Go back
108.0, 536.0
23.0, 23.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016653 MO000022200

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m1632*m6500*0.1

nodelay

--

true

0

false

PMID: 18304834 Originally identified in B cells, RP105 is a homolog of TLR4 and associates with the MD-2 homolog MD-1.

Go back
565.0, 349.0
21.0, 21.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 e20

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m66*m20*0.1

nodelay

--

true

0

false

PMID: 18304834 By interacting with TLR4/MD-2 directly, RP105/MD-1 can inhibit the association between LPS and TLR4/MD-2

Go back
342.0, 770.0
20.0, 20.0

p45

p45

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000044794 MO000016573

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m22464*m1572*0.1

nodelay

--

true

0

false

PMID:18304834 ST2 L can interact with MyD88 and TIRAP and inhibit their function by sequestration, thereby preventing recruitment to TLR4.

Go back
342.0, 682.0
20.0, 20.0

p45

p46

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

MO000044794 MO000022528

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m22464*m6810*0.1

nodelay

--

true

0

false

PMID:18304834 ST2L can interact with MyD88 and TIRAP and inhibit their function by sequestration, thereby preventing recruitment to TLR4.

Go back
806.0, 266.0
19.0, 19.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 e43

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m71*m44*0.1

nodelay

--

true

0

false

PMID: 18304834,16968706 TRIAD3A can interact with certain TIR domain containing proteins, such as TIRAP, TRIF and RIP1

Go back
810.0, 354.0
19.0, 19.0

p47

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000041125

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c1 : 1
stoichiometry:c145 : 1

m71*m18998*0.1

nodelay

--

true

0

false

PMID: 18304834,16968706 TRIAD3A can interact with certain TIR domain containing proteins, such as TIRAP, TRIF and RIP1

Go back
578.0, 318.0
19.0, 19.0

p47

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000022528

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m71*m6810*0.1

nodelay

--

true

0

false

PMID: 18304834,16968706 TRIAD3A can interact with certain TIR domain containing proteins, such as TIRAP, TRIF and RIP1

Go back
713.0, 41.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e12

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m19940*m12*0.1

nodelay

--

true

0

false

PMID: 18304834 While TLR3 interacts with viral double-stranded RNA, TLR7/8 can sense guanosine- or uridine-rich single-stranded RNA from viruses

Go back
809.0, 413.0
21.0, 21.0

p50

p50

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

MO000019394 e69

e10

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c150 : 1
stoichiometry:c151 : 1

m3961*m71*0.1

nodelay

--

true

0

false

PMID: 18304834,15866876,15107846 Overexpression of TRIAD3A can promote the degradation of TLR4, TIRAP, TRIF and RIP1 [

Go back
741.0, 645.0
21.0, 21.0

p50

p51

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e69 MO000022528

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1
stoichiometry:c154 : 1

m71*m6810*0.1

nodelay

--

true

0

false

PMID: 18304834,15866876,15107846 Overexpression of TRIAD3A can promote the degradation of TLR4, TIRAP, TRIF and RIP1 [

Go back
749.0, 293.0
21.0, 21.0

p50

p52

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e69 MO000041125

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c156 : 1
stoichiometry:c157 : 1

m71*m18998*0.1

nodelay

--

true

0

false

PMID: 18304834,15866876,15107846 Overexpression of TRIAD3A can promote the degradation of TLR4, TIRAP, TRIF and RIP1 [

Go back
785.0, 209.0
21.0, 21.0

p50

p53

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e69 e43

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m71*m44*0.1

nodelay

--

true

0

false

PMID: 18304834,15866876,15107846 Overexpression of TRIAD3A can promote the degradation of TLR4, TIRAP, TRIF and RIP1 [

Go back
425.0, 861.0
21.0, 21.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e73 e69 e76 e78

MO000000058

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c163 : 1
stoichiometry:c181 : 1
stoichiometry:c185 : 1
stoichiometry:c162 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 18304834,15107846 TRIAD3A overexpression can downregulate NF-¦ÊB activation, and knockingdown TRIAD3A expression upregulates NF-¦ÊB activation upon LPS stimulation PMID: 18304834,16415872 TRAF4 overexpression can inhibit NF-¦ÊB activation possibly through the interaction with TRIF and TRAF6

Go back
805.0, 721.0
21.0, 21.0

p55

p55

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

MO000017004 MO000022528

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c166 : 1

m1906*m6810*0.1

nodelay

--

true

0

false

PMID: 18304834 SOCS-1 can induce the ubiquitination of TIRAP which leads to its subsequent degradation

Go back
724.0, 860.0
23.0, 23.0

p56

p56

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e74

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18304834 SOCS-1 can induce the ubiquitination of TIRAP which leads to its subsequent degradation

Go back
914.0, 1014.0
19.0, 19.0

p57

p57

cso30:i:ME_Dissociation

cso30:i:CC_Extracellular

--

e26 MO000016569

e25 e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c171 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1

m26*0.1

nodelay

--

true

0

false

PMID: 1830483,15292196 Biochemical evidence also suggests that IRAK-4 is responsible for the subsequent recruitment, activation and degradation of IRAK-1 PMID: 18304834 Studies have suggested that IRAK-M inhibits MyD88-mediated signaling by preventing the dissociation of IRAKs from MyD88.

Go back
497.0, 233.0
21.0, 21.0

p58

p58

cso30:i:ME_Cleavage

cso30:i:CC_Extracellular

--

MO000041125 e75 MO000016962

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m18998*m77*m1871*0.1

nodelay

--

true

0

false

PMID: 18304834 TRIF induces the cleavage of TRAF1 by caspases (likely caspase-8) and the cleaved fragment of TRAF1 can inhibit TRIF-induced NF-¦ÊB and IRF3 activation

Go back
397.0, 296.5
22.5, 22.5

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016964 MO000041125

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m1873*m18998*0.1

nodelay

--

true

0

false

PMID: 18304834,16415872 TRAF4 overexpression can inhibit NF-¦ÊB activation possibly through the interaction with TRIF and TRAF6

Go back
1057.0, 193.0
21.0, 21.0

p5

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 1830483 While TLR3 interacts with viral double-stranded RNA, TLR7/8 can sense guanosine- or uridine-rich single-stranded RNA from viruses

Go back
489.0, 364.5
22.5, 22.5

p59

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016964 MO000000212

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c183 : 1
stoichiometry:c184 : 1

m1873*m183*0.1

nodelay

--

true

0

false

PMID: 18304834,16415872 TRAF4 overexpression can inhibit NF-¦ÊB activation possibly through the interaction with TRIF and TRAF6

Go back
318.0, 38.0
19.0, 19.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 MO000019422

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m3964*m3987*0.1

nodelay

--

true

0

false

PMID: 18304834 For example, the TLR2/TLR6 heterodimer can be stimulated by several bacterial components, such as lipoteichoic acid (LTA) and peptidoglycan (PGN)

Go back
865.0, 61.0
22.0, 22.0

p5

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e12

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m19823*m12*0.1

nodelay

--

true

0

false

PMID: 18304834 While TLR3 interacts with viral double-stranded RNA, TLR7/8 can sense guanosine- or uridine-rich single-stranded RNA from viruses

Go back
1198.0, 286.0
19.0, 19.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019420

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m155666*m3985*0.1

nodelay

--

true

0

false

PMID: 1830483,2427635,2477488 LBP is a soluble shuttle protein which directly binds to LPS and facilitates the association between LPS and CD14

Go back
1062.0, 474.0
19.0, 19.0

p8

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000019394

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c35 : 1
stoichiometry:c27 : 1

m16*m3961*0.1

nodelay

--

true

0

false

PMID: 1830483,11854525,11062499 Evidence suggests that several PAMPs can stimulate TLR4. These molecules include lipopolysaccharide (LPS) from Gram-negative bacteria, fusion (F) protein from respiratory syncytial virus (RSV) and the envelope protein from mouse mammary tumor virus (MMTV)

Go back
836.3846153846154, 325.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
532.0, 55.521687432131

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
209.99857638578817, 256.0

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.7527773913836, 356.97343424507943

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
676.6171643182392, 133.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
208.98679757511752, 325.45941755963065

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
277.0, 298.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
299.2570816034594, 302.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.1877316447983, 368.0899458438937

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
201.0, 327.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
209.8166078904625, 359.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
203.0, 410.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
625.1143024185452, 48.658784100966095

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
289.0, 452.91605749347355

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
320.0, 446.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.0, 579.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
299.085750570332, 671.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
305.0, 828.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.0, 671.2299027111483

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
498.0, 566.9156885130728

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
521.0, 486.4

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
194.0, 281.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.5777087639997, 978.1554175279994

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
585.6825973242131, 50.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.0, 971.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
196.0, 281.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.4714175408546, 944.7032706717687

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
351.0, 937.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
137.17940388792766, 502.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 548.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
131.0, 556.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
203.0, 371.29017502030706

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
593.8523918966476, 363.5296867331132

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
586.0, 364.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.0, 64.68092557921909

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 412.95855394923973

c130

c130

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
205.0, 673.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.9942885896604, 780.3022415345807

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.7644623628549, 744.9269468637742

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
205.0, 666.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
369.99473512698773, 692.2901900227582

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
215.50986776965388, 699.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
209.0, 737.3100187101777

c137

c137

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
205.0, 741.0

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
199.0, 797.3732218398168

c139

c139

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
741.9418702562697, 53.9626509401539

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.0, 277.7434356128128

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
675.0, 192.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
592.586026806814, 201.5401175733223

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 295.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 231.90697358120494

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.8874122257146, 297.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
601.2633481417727, 343.0247129673121

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
573.9975603804354, 309.2469504755442

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.0866522822413, 342.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.885143449429, 62.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 298.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
830.0, 382.2192070284682

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 305.0

c152

c152

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
769.6093827696097, 661.4692699053701

c153

c153

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
754.0, 666.0

c154

c154

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 293.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
777.9619341402129, 305.7794900556852

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.0, 314.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
656.0, 228.51068238804

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.0, 190.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.0, 205.77059355888153

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 230.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.20449602968955, 885.0501711869566

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 874.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
441.3718545479015, 305.0

c163

c163

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
411.0, 420.0

c164

c164

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
833.8680491917036, 714.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.485433827199, 740.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
707.0, 827.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 883.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.020613557655, 985.2680368629482

c169

c169

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.7362590055861, 211.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.0, 951.0727595223594

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.0, 997.0

c171

c171

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
525.8703209039886, 247.43459013946122

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
370.0, 240.0

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
431.0, 212.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 254.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
333.20914563457205, 304.0

c176

c176

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
362.0, 323.20633098764773

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.9976311600627, 308.1946685069386

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 221.99993265790187

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
412.0, 319.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
436.0, 403.0

c181

c181

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
362.0, 357.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
506.8051918846365, 394.4920556918892

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.1500042580955, 385.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
362.0, 504.0

c185

c185

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
301.0, 64.45366401388742

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
333.3624501667941, 64.64322112786321

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 47.557469841935585

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0, 78.43820581683028

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
880.3342495826046, 1024.0

c2

c2

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
809.0, 63.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.6568542494924, 83.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1208.0, 246.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.0, 296.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1208.0, 305.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1089.0, 484.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1150.0, 348.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.9922258795006, 484.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 572.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 347.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.02167504037726, 304.0

c3

c3

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
996.9880172185127, 572.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1102.0, 302.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1142.0, 357.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.0, 337.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 352.78467530313964

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 347.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1005.9944553544719, 351.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1122.0, 400.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 406.4817378249292

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1008.983840463331, 410.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
442.0, 69.45912897806318

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.0, 638.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.913627698831, 678.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.0, 695.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 714.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
997.6115561484353, 739.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
990.0, 767.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.0, 796.2024667731639

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.9977141520185, 801.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.0, 851.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.0, 872.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.0, 52.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.0158059186881, 878.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 929.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 968.1692742632486

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.9518791310188, 974.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.9904988089992, 1021.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
867.0, 980.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
764.0, 1051.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
803.9085167916562, 1073.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
938.0, 1128.352465419694

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
902.9671456517416, 1145.7242859683402

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.31519189844283, 63.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.8650403958687, 1086.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.0, 1087.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
734.591463582408, 1110.721497619208

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.3260780821423, 1105.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
693.0, 1172.0

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
713.8874480940947, 1218.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.0, 1252.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 1073.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
477.0, 1127.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 1176.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
199.0, 61.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.0, 1098.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
609.0913238058265, 1196.7218109753596

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
550.0, 1090.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 1065.9885450581608

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 1252.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
427.0, 1255.669107774164

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.98206517698503, 1217.9052228956018

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
559.0, 964.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 982.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
622.0, 964.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.02557268678464, 82.99995912725126

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.4022870018616, 906.6307940059136

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
683.0, 894.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
594.9279394432826, 889.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.0, 864.7120559573644

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 758.9261327642199

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
678.0, 657.909274117848

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
634.9620548405717, 607.9407857588142

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
372.41396691024454, 1163.7813207876368

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
295.0, 1152.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
358.0, 1074.8968438219806

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
204.2141339463039, 75.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.0, 731.8882691508882

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
575.0, 611.6749240125702

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
870.8009082980395, 373.4936581658075

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 374.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 187.75606862759741

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.5838237573311, 175.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
868.1161785822062, 273.15677802029154

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
861.0, 143.26328444040598

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
644.383083722649, 201.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.4109380354009, 128.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back