1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18321608.csml convertedTime:2009.07.01.11:17

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Nucleic acid-sensing Toll-like receptors: beyond ligand search.
Authors Miyake K.
Affiliation Division of Infectious Genetics, Department of Microbiology and Immunology, TheInstitute of Medical Science, University of Tokyo, Japan.kmiyake@ims.u-tokyo.ac.jp
Abstract Nucleic acids from microbes were known to be immunogenic for a long time, buttheir sensors have been only recently identified. Two types of sensors,Toll-like receptors (TLR) and the RIG-I-like receptors (RLR), principallyrespond to nucleic acid. Discovery of these sensors have opened basic researchas to how our immune system handles microbial nucleic acids. Recent resultsdemonstrate that functional interaction between pathogen sensors is criticallyinvolved in the extent and type of immune responses. Moreover, responsiveness ofnucleic acid-sensing TLRs is profoundly influenced by molecules associated withTLRs or with nucleic acids. Our understanding of mechanisms by which TLRresponses were controlled would contribute to development of drugs such asimmunostimulatory nucleic acids or small chemicals antagonizing TLRs.
PMID 18321608
Model Abstract

Entity

G010262:IL-6 G010329:TNF-alpha G010657:IL-12 p40 G010693:Tlr4 G013260:TLR7 MO000000054:Bcr MO000000289:TNF-alpha MO000007384:IL-6 MO000016658:IFN Type I MO000016659:IFNalpha MO000017265:IL-12 MO000018132:CD14 MO000019394:TLR4 MO000019398:TLR3 MO000022224:dsRNA MO000041446:dsRNA:TLR3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000042134:TLR13 MO000044940:HMGB MO000061425:DAI MO000103999:MDA-5 e1: e10: e11: e12: e13:TLR1: TLR2 e14:TLR2: TLR6 e15:endosomal ssRNA e16:ssRNA: TLR7 e17:endosomal DNA e18:endosomal DNA: TLR9 e19:RIG-1 e2: e20:ssRNA: RIG-1 e21:ssRNA{cytoplasmic} e22:dsRNA{cytoplasmic} e23:dsRNA: MDA-5 e24:DNA{cytoplasmic} e25:DNA: DAI e26:microbial membrane lipid e27:microbial membrane lipid: TLR1: TLR2 e28:microbial membrane lipid: TLR2: TLR6 e29:microbial membrane lipid: TLR4: MD-2 e3: e30:microbial nucleic acid e31:microbial nucleic acid: TLR3 e32:microbial nucleic acid: TLR7 e33:microbial nucleic acid: TLR8 e34:microbial nucleic acid: TLR9 e35:cytokine e36:Unc93B e37:Unc93B: TLR3 e38:Unc93B: TLR7 e39:Unc93B: TLR9 e4: e40:Unc93B: TLR13 e41: e42: e43: e44: e45: e46: e47:TLR9{ER} e48:PRAT4A e49:lipid A e5:TLR4: MD-2 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:PRAT4A e64:DNA e65:HGMB: DNA{nuclear} e66:DNA e67:DNA: BCR e68:DNA associated autoantigens: TLR9 e69:DNA associated autoantigens e7: e70:HGMB1: DNA e71:HGMB1: DNA: TLR9 e72:RNA e73:RNA: BCR e74:RNA associated autoantigens e75:RNA associated autoantigens: TLR7 e76:IFNalpha e77: e78: e79: e8: e80: e81: e82: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p5 p6 p7 p8 p9
Model Detail
570.0, 1008.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p39

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
646.0, 1010.0
28.5, 28.5

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
577.0, 794.0
30.0, 30.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p14 p15 p16 p17 p18 p19

p38

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
741.0, 757.0
30.0, 30.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
722.0, 890.0
28.0, 28.0

TLR7

--

G013260

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p26

--

true true true true

csml-variable:Double

m95743

10

false

infinite

0

unit false false false
TRANSFACG013260

--

Go back
855.0, 1139.0
28.0, 28.0

Bcr

--

MO000000054

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p41

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
InterProIPR001849
TRANSPATHMO000000054

--

Go back
484.0, 1200.0
32.0, 32.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
85.0, 1009.0
29.0, 29.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

--

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
906.0, 890.0
28.0, 28.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
783.0, 1071.0
31.0, 31.0

IFNalpha

--

MO000016659

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

--

true true true true

csml-variable:Double

m1635

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
89.0, 889.0
29.0, 29.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

--

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
1017.0, 261.0
29.0, 29.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p7 p8 p9

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
977.0, 757.0
29.5, 29.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

--

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
413.0, 209.0
22.0, 22.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p10 p27

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
411.0, 311.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
495.0, 231.0
25.5, 25.5

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
331.0, 403.0
25.0, 25.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
311.0, 547.0
26.0, 26.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p3 p13 p29 p36 p37

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
317.0, 325.0
22.0, 22.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p11 p28 p42

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
976.0, 456.0
32.0, 32.0

TLR13

--

MO000042134

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m19948

10

false

infinite

0

unit false false false
TRANSPATHMO000042134

--

Go back
793.0, 805.0
30.0, 30.0

HMGB

--

MO000044940

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m22603

10

false

infinite

0

unit false false false
TRANSPATHMO000044940

--

Go back
826.0, 114.0
28.0, 28.0

DAI

--

MO000061425

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m36323

10

false

infinite

0

unit false false false
TRANSPATHMO000061425

--

Go back
702.0, 127.0
28.0, 28.0

MDA-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
219.97597027272127, 48.593301862930076
804.3250828525764, 1121.4633691821916

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
229.47135055220056, 100.79622561532693
753.8591837289215, 1018.3202735342949

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
321.87855801869785, 219.7620086094097
268.64339218326245, 448.49786661103997

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
321.87855801869785, 219.7620086094097
268.64339218326245, 448.49786661103997

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
976.625, 101.5
36.75, 45.0

TLR1: TLR2

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p9

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
979.625, 212.5
31.099608398600232, 38.08115314114314

TLR2: TLR6

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p8

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
477.5, 353.625
37.93666026871401, 20.865163147792707

endosomal ssRNA

--

e15

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
317.625, 246.5
29.368563572737877, 35.9615064155974

ssRNA: TLR7

--

e16

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p1

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
460.5, 500.125
45.0, 15.75

endosomal DNA

--

e17

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p3

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
308.625, 489.5
31.00979003499417, 37.97117147142143

endosomal DNA: TLR9

--

e18

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p3

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
599.375, 139.5
21.276362038664324, 32.73286467486819

RIG-1

--

e19

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
219.97597027272127, 48.593301862930076
804.3250828525764, 1121.4633691821916

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
600.375, 193.5
18.92046700285025, 36.620258715194026

ssRNA: RIG-1

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
523.5, 145.625
37.8598848368522, 20.822936660268716

ssRNA{cytoplasmic}

--

e21

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
638.0, 115.0
26.0, 26.0

dsRNA{cytoplasmic}

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
699.625, 169.5
29.8993084485919, 36.61139810031661

dsRNA: MDA-5

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
753.5, 112.125
45.0, 15.75

DNA{cytoplasmic}

--

e24

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p6

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
826.625, 161.5
27.229253457757046, 33.341943009498415

DNA: DAI

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
1119.5, 187.375
39.41124780316344, 25.61731107205624

microbial membrane lipid

--

e26

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p7 p8 p9

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
980.875, 151.5
28.935630390897412, 40.37529821985685

microbial membrane lipid: TLR1: TLR2

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p9

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
984.875, 291.5
29.874701780143145, 41.685630390897416

microbial membrane lipid: TLR2: TLR6

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p18 p24

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
981.875, 389.5
27.578317122407782, 38.48137272894109

microbial membrane lipid: TLR4: MD-2

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p19 p25

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
236.06247192977273, 64.0404557084149
772.1520795384736, 1090.5690614912226

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
81.5, 427.25
45.0, 25.5

microbial nucleic acid

--

e30

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10 p11 p12 p13

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
358.625, 211.5
26.290243292784538, 32.192134644225966

microbial nucleic acid: TLR3

--

e31

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p10

p17 p23

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
323.625, 356.5
25.000124979170142, 30.612397933677716

microbial nucleic acid: TLR7

--

e32

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

p16 p22

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
331.625, 448.5
24.640851524745877, 30.172471254790867

microbial nucleic acid: TLR8

--

e33

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p12

p15 p21

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
313.625, 586.5
29.139935010831532, 35.68155307448758

microbial nucleic acid: TLR9

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

p14 p20 p43 p44

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
529.5, 896.0
45.0, 24.0

cytokine

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p20 p21 p22 p23 p24 p25

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
697.5, 424.125
37.69470718454418, 23.245069430468906

Unc93B

--

e36

cso30:c:Protein

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

p27 p28 p29 p30

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
553.625, 319.5
28.07027995334111, 34.37177137143809

Unc93B: TLR3

--

e37

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p27

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
570.625, 463.5
26.829153474420924, 32.85202466255624

Unc93B: TLR7

--

e38

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p28

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
546.625, 547.5
26.967963672721208, 33.021996333944344

Unc93B: TLR9

--

e39

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p29

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
265.82249999531825, 91.07297493801309
712.6320234073831, 1036.5040230320255

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
976.625, 509.5
29.8993084485919, 36.61139810031661

Unc93B: TLR13

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
594.916616141042, 611.2217451234877
98.79408755459401, 28.504523622309094

--

e41

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false true false

--

Go back
595.7264037439486, 612.0315327263944
97.17451234878096, 26.884948416496087

--

e42

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false true false

--

Go back
593.9448710175542, 610.25
100.73757780156956, 30.448013869284722

--

e43

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false true false

--

Go back
593.9448710175542, 610.25
100.73757780156956, 30.448013869284722

--

e44

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false true false

--

Go back
595.4024887027858, 611.7076176852316
97.82234243110615, 27.532778498821276

--

e45

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false true false

--

Go back
593.9448710175542, 610.25
100.73757780156956, 30.448013869284722

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false true false

--

Go back
631.0, 612.0
26.0, 26.0

TLR9{ER}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
870.125, 636.5
20.422972429060174, 33.118333668746224

PRAT4A

--

e48

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31 p32

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1099.5, 951.25
45.0, 25.5

lipid A

--

e49

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p33

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
978.625, 340.5
32.520371604732546, 39.82086318946842

TLR4: MD-2

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p7

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
437.8393735072271, 692.8553699892243
417.69745775455164, 363.7503094035687

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
482.953810285186, 701.475723512317
244.2402266944679, 352.54650110571754

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
443.2842193252568, 697.7103535849599
406.8077661184927, 354.0403422120975

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
444.06205444211827, 698.4572741381495
405.2520958847698, 352.54650110571754

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
437.8393735072271, 692.8553699892243
417.69745775455164, 363.7503094035687

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
437.8393735072271, 692.8553699892243
417.69745775455164, 363.7503094035687

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
444.06205444211827, 698.4572741381495
405.2520958847698, 352.54650110571754

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
742.750739316881, 842.2394806272398
26.095442120121113, 22.684351547630303

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
674.3012490330813, 946.8083580738517
73.89433610182941, 64.23516757434687

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
437.8393735072271, 692.8553699892243
417.69745775455164, 363.7503094035687

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
321.87855801869785, 219.7620086094097
268.64339218326245, 448.49786661103997

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
536.2883140781494, 854.5030017946189
13.227864745142297, 6.11584116270964

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
535.8465982317587, 836.2641162017192
45.27587425504342, 78.2575439974435

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
554.8403796265579, 887.163331809812
7.067453542250673, 6.786562081079109

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
727.5, 953.0
37.88927335640139, 20.207612456747405

PRAT4A

--

e63

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p33

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
705.5, 792.125
45.0, 9.75

DNA

--

e64

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p34

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
793.5, 845.625
45.0, 12.75

HGMB: DNA{nuclear}

--

e65

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p34

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
782.5, 1201.125
45.0, 15.75

DNA

--

e66

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
789.625, 1129.5
31.279245125812363, 38.301116480586565

DNA: BCR

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
458.625, 627.5
27.719171804699222, 33.9418430261623

DNA associated autoantigens: TLR9

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

--

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
92.5, 708.125
31.240000000000002, 23.43

DNA associated autoantigens

--

e69

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
230.19421692918166, 52.95694485084019
762.7114891190182, 1037.7890542702087

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
89.5, 653.625
45.0, 12.75

HGMB1: DNA

--

e70

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

--

p37

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
365.625, 641.5
29.589026828861858, 36.23146142309615

HGMB1: DNA: TLR9

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p38 p39 p40

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
985.5, 1197.625
39.971209213051814, 21.984165067178502

RNA

--

e72

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p41

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
918.625, 1135.5
28.87047992001333, 35.351608065322445

RNA: BCR

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
104.5, 288.125
30.6, 22.949999999999996

RNA associated autoantigens

--

e74

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p42

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
311.625, 285.5
23.848816863856023, 29.20263289451758

RNA associated autoantigens: TLR7

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
705.5, 990.0
37.88927335640139, 20.207612456747405

IFNalpha

--

e76

cso30:c:mRNA

cso30:i:CC_Nucleolus

--

--

p44

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
643.4582642553312, 399.63854126206735
201.50676885474368, 55.75020604981249

--

e77

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false true false

--

Go back
639.7639734929943, 395.9442504997304
208.89535037941752, 63.13878757448647

--

e78

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false true false

--

Go back
639.7639734929943, 395.9442504997304
208.89535037941752, 63.13878757448647

--

e79

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false true false

--

Go back
232.9190827042378, 71.2729188351502
731.6782198068373, 1020.1724887550249

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
642.7865750258154, 398.96685203255157
202.8501473137753, 57.09358450884413

--

e80

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false true false

--

Go back
639.7639734929943, 395.9442504997304
208.89535037941752, 63.13878757448647

--

e81

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false true false

--

Go back
641.7790411815416, 397.9593181882779
204.86521500232274, 59.108652197391564

--

e82

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false true false

--

Go back
240.1853914377208, 89.5888928194602
728.3377073827506, 1006.7931821970988

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
412.0, 352.0
23.0, 23.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m19940*m15*0.1

nodelay

--

true

0

false

PMID: 18321608, 11095740, 11812998, 11607032 Endosomal ssRNA, dsRNA, and DNA are recognized by TLR7, TLR3, and TLR9, respectively[3], [4] and [5].

Go back
234.0, 214.0
27.0, 27.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000019398

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c35 : 1
stoichiometry:c39 : 1

m30*m3965*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.

Go back
243.0, 359.0
25.0, 25.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000042126

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c36 : 1
stoichiometry:c43 : 1

m30*m19940*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.

Go back
243.0, 427.0
26.0, 26.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000042007

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c37 : 1
stoichiometry:c41 : 1

m30*m19823*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.

Go back
239.0, 547.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 MO000042012

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c38 : 1
stoichiometry:c42 : 1

m30*m19828*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids.

Go back
518.0, 755.0
27.0, 27.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c52 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
500.0, 785.0
23.0, 23.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c51 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
483.0, 816.0
25.0, 25.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c50 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
476.0, 853.0
23.0, 23.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c49 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
610.0, 715.0
27.0, 27.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c53 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
663.0, 716.0
25.0, 25.0

p19

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c54 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
412.0, 265.0
23.0, 23.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224 MO000018132

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c69 : 1
stoichiometry:c3 : 1

m3965*m119368*m2828*0.1

nodelay

--

true

0

false

PMID: 18321608, 11095740, 11812998, 11607032 Endosomal ssRNA, dsRNA, and DNA are recognized by TLR7, TLR3, and TLR9, respectively[3], [4] and [5]. PMID: 18321608, 16473828 Recently, cell surface CD14 was reported to enhance TLR3 response as well by upregulating cellular uptake of dsRNA.

Go back
475.0, 892.0
25.0, 25.0

p20

p20

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c55 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
483.0, 923.0
25.0, 25.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c56 : 1

m33*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
499.0, 955.0
25.0, 25.0

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e32

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c57 : 1

m32*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
541.0, 973.0
22.0, 22.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e31

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c58 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
599.0, 895.0
25.0, 25.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e28

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c63 : 1

m28*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
599.0, 923.0
25.0, 25.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e29

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c64 : 1

m29*0.1

nodelay

--

true

0

false

PMID: 18321608, 15995707 A synergistic relationship between TLR3/4 and TLR7/8/9 has been recently reported in the triggering of IL-12 and other Th1-promoting cytokines by DCs.

Go back
800.0, 892.0
23.0, 23.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000016658

G013260

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 18321608 Selective regulation by type I IFN of TLR7 expression is likely to contribute to autoantibody production and autoimmunity.

Go back
483.0, 324.0
26.0, 26.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 e36

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c71 : 1
stoichiometry:c74 : 1

m3965*m36*0.1

nodelay

--

true

0

false

PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.

Go back
482.0, 423.0
27.0, 27.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e36 MO000042126

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c77 : 1
stoichiometry:c75 : 1

m36*m19940*0.1

nodelay

--

true

0

false

PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.

Go back
463.0, 548.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e36 MO000042012

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c78 : 1
stoichiometry:c76 : 1

m36*m19828*0.1

nodelay

--

true

0

false

PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.

Go back
382.0, 495.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m19828*m17*0.1

nodelay

--

true

0

false

PMID: 18321608, 11095740, 11812998, 11607032 Endosomal ssRNA, dsRNA, and DNA are recognized by TLR7, TLR3, and TLR9, respectively[3], [4] and [5].

Go back
866.0, 459.0
27.0, 27.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000042134

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m36*m19948*0.1

nodelay

--

true

0

false

PMID: 18321608 Unc93B specifically interacts with TLR3, 7, 9, and 13.

Go back
871.0, 759.0
26.0, 26.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010693 e48

MO000019394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c86 : 1
stoichiometry:c82 : 1

m93614*m48*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface expression of TLR4 was apparently downregulated by PRAT4A knockdown, demonstrating that PRAT4A serves as a chaperone for TLR4.

Go back
542.0, 639.0
27.0, 27.0

p32

p32

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e47 e48

MO000042012

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c87 : 1
stoichiometry:c85 : 1

m47*m48*0.1

nodelay

--

true

0

false

PMID: 18321608, 17998391, 14716310 TLR9 resides in the ER and traffics to endosome/lysosome for ligand recognition [22]. TLR9 in PRAT4A-silenced cells is unable to traffic to endosome/lysosome.

Go back
786.0, 951.0
23.0, 23.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c88 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18321608 Interestingly, expression of PRAT4A mRNA in bone marrow-derived dendritic cells is downregulated by stimulation with TLR ligands such as lipid A.

Go back
716.0, 840.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e64 MO000044940

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m64*m22603*0.1

nodelay

--

true

0

false

PMID: 18321608, 16813837 The high-mobility group box (HMGB) proteins are highly abundant chromatin-binding proteins located mainly in the cell nucleus, where they bind to the minor groove of DNA.

Go back
856.0, 1196.0
26.0, 26.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000054 e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m67*m66*0.1

nodelay

--

true

0

false

PMID: 18321608, 11948342 DNA and DNA-associated autoantigens activate autoreactive B cells via sequential engagement of the B cell antigen receptor (BCR) and TLR9.

Go back
458.0, 706.0
27.0, 27.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e69

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c98 : 1
stoichiometry:c97 : 1

m19828*m70*0.1

nodelay

--

true

0

false

PMID: 18321608, 11948342 DNA and DNA-associated autoantigens activate autoreactive B cells via sequential engagement of the B cell antigen receptor (BCR) and TLR9.

Go back
240.0, 648.0
23.0, 23.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042012 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m19828*m71*0.1

nodelay

--

true

0

false

PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.

Go back
318.0, 890.0
28.0, 28.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010657 e71

MO000017265

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m93589*m72*0.1

nodelay

--

true

0

false

PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.

Go back
417.0, 1009.0
27.0, 27.0

p39

p39

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010262 e71

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c109 : 1
stoichiometry:c105 : 1

m93248*m72*0.1

nodelay

--

true

0

false

PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.

Go back
530.0, 200.0
23.0, 23.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 e21

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19*m21*0.1

nodelay

--

true

0

false

PMID: 18321608, 15208624, 17618271, 16625202 Cytoplasmic ssRNA, dsRNA, and DNA are sensed by retinoic acid inducible gene I (RIG-1), melanoma associated gene 5 (MDA5), and DNA-dependent activator of IFN-regulatory factors (DAI), respectively.

Go back
487.0, 1075.0
25.0, 25.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010329 e71

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c107 : 1

m93309*m72*0.1

nodelay

--

true

0

false

PMID: 18321608, 17548579 HMGB1 was identified as molecule that binds to a TLR9 ligand CpG. HMGB1 accelerates the delivery of CpG-ODNs to its receptor, leading to a TLR9-dependent augmentation of IL-6, IL-12, and TNFalpha secretion.

Go back
919.0, 1195.0
27.0, 27.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e72 MO000000054

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m73*m67*0.1

nodelay

--

true

0

false

PMID: 18321608, 16260486 Similarly, RNA and RNA-associated autoantigens activate B cells by engaging BCR and TLR7.

Go back
235.0, 287.0
25.0, 25.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e74 MO000042126

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m75*m19940*0.1

nodelay

--

true

0

false

PMID: 18321608, 16260486 Similarly, RNA and RNA-associated autoantigens activate B cells by engaging BCR and TLR7.

Go back
95.0, 591.0
25.0, 25.0

p43

p43

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e34

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18321608, 15815647, 16864658 Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by pDCs, whereas TLR9 signaling in late endosomes induces pDC maturation, IL-6 and TNF-alpha secretion.

Go back
711.0, 1071.0
25.0, 25.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e76 e34

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c120 : 1
stoichiometry:c119 : 1

m77*m34*0.1

nodelay

--

true

0

false

PMID: 18321608, 15815647, 16864658 Recent studies have suggested that TLR9 signaling in early endosomes leads to IFN-alpha production by pDCs, whereas TLR9 signaling in late endosomes induces pDC maturation, IL-6 and TNF-alpha secretion.

Go back
639.0, 176.0
23.0, 23.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m76904*m22*0.1

nodelay

--

true

0

false

PMID: 18321608, 15208624, 17618271, 16625202 Cytoplasmic ssRNA, dsRNA, and DNA are sensed by retinoic acid inducible gene I (RIG-1), melanoma associated gene 5 (MDA5), and DNA-dependent activator of IFN-regulatory factors (DAI), respectively.

Go back
762.0, 164.0
27.0, 27.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000061425

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m24*m36323*0.1

nodelay

--

true

0

false

PMID: 18321608, 15208624, 17618271, 16625202 Cytoplasmic ssRNA, dsRNA, and DNA are sensed by retinoic acid inducible gene I (RIG-1), melanoma associated gene 5 (MDA5), and DNA-dependent activator of IFN-regulatory factors (DAI), respectively.

Go back
1070.0, 347.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 e5 MO000018132

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c26 : 1
stoichiometry:c30 : 1
stoichiometry:c27 : 1

m26*m5*m2828*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids. PMID: 18321608 Cell surface CD14 is known to augment cell surface TLRs such as TLR2 and TLR4/MD-2.

Go back
1079.0, 268.0
23.0, 23.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 e14 MO000018132

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c22 : 1
stoichiometry:c29 : 1
stoichiometry:c23 : 1

m26*m14*m2828*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids. PMID: 18321608 Cell surface CD14 is known to augment cell surface TLRs such as TLR2 and TLR4/MD-2.

Go back
1061.0, 110.0
27.0, 27.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 e13 MO000018132

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c24 : 1
stoichiometry:c28 : 1
stoichiometry:c25 : 1

m26*m13*m2828*0.1

nodelay

--

true

0

false

PMID: 18321608 Cell surface TLRs, including TLR4/MD-2, TLR1/TLR2, and TLR6/TLR2, recognize microbial membrane lipids, whereas TLR3, TLR7/8, and TLR9 reside in intracellular organelles and recognize microbial nucleic acids. PMID: 18321608 Cell surface CD14 is known to augment cell surface TLRs such as TLR2 and TLR4/MD-2.

Go back
424.0, 231.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
559.1676940130167, 165.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 660.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
263.0, 660.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
353.5078541385816, 814.0

c102

c102

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
336.5546894146929, 678.0

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
126.0, 904.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
121.9999564316426, 1023.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.999748059269, 1022.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
500.0, 1100.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
519.9999858702542, 1039.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
382.0, 678.0

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.0, 166.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.0, 678.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
954.0, 1209.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0, 1165.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
933.0, 1179.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
135.0, 300.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
267.2785523863447, 308.3200414393853

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 300.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
128.0, 604.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
724.0, 1010.0

c118

c118

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
736.0, 1084.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
553.0, 212.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
187.9865034587026, 607.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
668.4768835471551, 151.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.0, 141.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 188.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 128.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
795.2964473212105, 139.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.0, 178.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1091.1455366913863, 143.1256389183169

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 296.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1102.1159660434203, 213.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1090.597481688091, 213.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1011.0, 240.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.5285977302406, 284.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1013.0, 124.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.8361755317706, 132.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1011.0, 360.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1015.9878479129105, 367.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.0, 144.69918131544756

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1046.0, 277.0

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
435.0, 251.97112541083283

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1040.0, 290.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
103.97622216167383, 228.00635649741696

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
108.0, 371.63622361637164

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
127.0, 440.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
104.0, 453.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
268.9915300906429, 220.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
275.1260949576659, 341.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.7152317131197, 419.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.0, 560.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.0, 228.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.0, 339.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
151.8997648553881, 230.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
269.0, 444.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 567.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
268.0, 372.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
199.93867081249152, 376.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
215.61759070799997, 464.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
332.0, 622.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
642.356818586473, 329.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.9999994984031, 412.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
499.0, 820.7927985842801

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.0, 364.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 813.5907742895922

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.0, 799.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.0, 778.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.9957043968103, 742.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.7587543633655, 741.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 906.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
508.0, 922.5777087639997

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
521.0, 926.6856438376102

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 928.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
330.0, 622.0

c59

c59

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
352.40579702813875, 285.89723312160595

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
284.1111054802289, 468.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
303.87273826563387, 387.0

c61

c61

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
171.91560638286978, 230.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
583.0, 908.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
582.2725185831542, 922.3332376839458

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
624.3657749721165, 333.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.9999810216096, 404.9659284479394

c66

c66

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
758.0, 904.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.0, 904.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
442.9999982269269, 276.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
337.0, 522.7309093090201

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 231.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.2960941788635, 346.2813121968434

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
516.9998880234031, 436.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.10050039108194, 446.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.0, 337.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
509.0, 443.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 561.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
339.0, 343.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
337.0, 560.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.0, 440.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.0, 508.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.9994194274095, 472.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 479.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
897.0, 772.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.0, 772.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.6136689420844, 629.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.4278135270821, 567.9711254108329

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.0, 670.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.0, 653.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
773.0, 963.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
812.9999763821603, 963.0137456233064

c89

c89

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
348.0, 508.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
728.0, 802.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.4087388781563, 826.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
739.0, 852.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.0, 1167.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.0, 1209.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
826.8207152494824, 1169.488102949512

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 573.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.0, 669.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
124.0, 720.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
265.6744378067606, 573.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back