_enti_e7
_enti_e8
_enti_e9
_enti_e1
_enti_e10
_enti_e2
_enti_e4
_enti_e3
_enti_e55
_enti_e53
_enti_e59
_enti_e51
_enti_e52
_enti_e50
_enti_e54
_enti_e56
_enti_e57
_enti_e58
_enti_e61
_enti_e60
_enti_e62
g1_fact_g1
g1_fact_g14
g2_fact_g13
p1_propro_p1
PMID: 18325755,17324405
Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p1_propro_p2
PMID: 18325755,17324405
Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan
c4 cso30:c:InputProcess connector
c5 cso30:c:InputProcess connector
c6 cso30:c:OutputProcess connector
p1_propro_p3
PMID: 18325755,17324405
Interestingly, TLR4 could also be activated by endogenous ligands produced during stress or cell damage, including heat-shock protein 60, ED-A domain of fibronectin, and hyaluronan
c7 cso30:c:InputProcess connector
c8 cso30:c:InputProcess connector
c9 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18325755,12001991
Constitutive NF-κB activation, often observed in cancer cells, may be promoted by either microenvironmental signals, including cytokines, hypoxia, and reactive oxygen intermediates (ROI), or by genetic alterations
c10 cso30:c:InputAssociation connector
c11 cso30:c:InputProcess connector
c12 cso30:c:OutputProcess connector
p4_propro_p5
PMID: 18325755,12001991
Constitutive NF-κB activation, often observed in cancer cells, may be promoted by either microenvironmental signals, including cytokines, hypoxia, and reactive oxygen intermediates (ROI), or by genetic alterations
c13 cso30:c:InputAssociation connector
c14 cso30:c:InputProcess connector
c15 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18325755,12490959,15766659,15485627
In particular, pro-inflammatory cytokines (e.g. IL-1 and TNF), expressed by infiltrating leukocytes, can activate NF-κB in cancer cells and contribute to their proliferation and survival
c16 cso30:c:InputAssociation connector
c17 cso30:c:InputProcess connector
c18 cso30:c:OutputProcess connector
p6_propro_p7
PMID: 18325755,12490959,15766659,15485627
In particular, pro-inflammatory cytokines (e.g. IL-1 and TNF), expressed by infiltrating leukocytes, can activate NF-κB in cancer cells and contribute to their proliferation and survival
c19 cso30:c:InputProcess connector
c21 cso30:c:InputAssociation connector
c20 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18325755,14673019,12925853
There is now evidence that TIR8, an orphan member of the IL-1R family (also known as single immunoglobulin IL-1R-related molecule, SIGIRR) inhibits signalling from the IL-1R/TLR complexes, possibly by trapping IRAK-1 and TRAF-6
c22 cso30:c:InputProcess connector
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18325755,14673019,12925853
There is now evidence that TIR8, an orphan member of the IL-1R family (also known as single immunoglobulin IL-1R-related molecule, SIGIRR) inhibits signalling from the IL-1R/TLR complexes, possibly by trapping IRAK-1 and TRAF-6
c25 cso30:c:InputProcess connector
c26 cso30:c:InputProcess connector
c27 cso30:c:InputProcess connector
c29 cso30:c:InputInhibitor connector
c28 cso30:c:OutputProcess connector
p8_propro_p10
PMID: 18325755,14673019,12925853
There is now evidence that TIR8, an orphan member of the IL-1R family (also known as single immunoglobulin IL-1R-related molecule, SIGIRR) inhibits signalling from the IL-1R/TLR complexes, possibly by trapping IRAK-1 and TRAF-6
c30 cso30:c:InputProcess connector
c31 cso30:c:InputProcess connector
c32 cso30:c:OutputProcess connector
p9_propro_p11
PMID: 18325755,14673019,12925853
There is now evidence that TIR8, an orphan member of the IL-1R family (also known as single immunoglobulin IL-1R-related molecule, SIGIRR) inhibits signalling from the IL-1R/TLR complexes, possibly by trapping IRAK-1 and TRAF-6
c33 cso30:c:InputProcess connector
c34 cso30:c:InputProcess connector
c35 cso30:c:InputProcess connector
c37 cso30:c:InputInhibitor connector
c36 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18325755,12925853,14715412
Tir8 gene transfer experiments have revealed that it reduces NF-κB activation by the IL-1R complex ,as well as by members of the TLR family such as TLR4
c38 cso30:c:InputAssociation connector
c39 cso30:c:InputProcess connector
c41 cso30:c:InputInhibitor connector
c40 cso30:c:OutputProcess connector
p12_propro_p13
PMID: 18325755,12925853,14715412
Tir8 gene transfer experiments have revealed that it reduces NF-κB activation by the IL-1R complex ,as well as by members of the TLR family such as TLR4
c42 cso30:c:InputAssociation connector
c43 cso30:c:InputProcess connector
c45 cso30:c:InputInhibitor connector
c44 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18325755,12925853,14715412
Tir8 gene transfer experiments have revealed that it reduces NF-κB activation by the IL-1R complex ,as well as by members of the TLR family such as TLR4
c46 cso30:c:InputAssociation connector
c47 cso30:c:OutputProcess connector
p15_propro_p15
PMID; 18325755,15542429
Transfer of activated ras oncogene into a cervical carcinoma line (HeLa) induces IL-8/CXCL8 production that is sufficient to promote angiogenesis and tumor progression
c48 cso30:c:InputAssociation connector
c49 cso30:c:OutputProcess connector
p16_propro_p16
PMID; 18325755,15542429
Transfer of activated ras oncogene into a cervical carcinoma line (HeLa) induces IL-8/CXCL8 production that is sufficient to promote angiogenesis and tumor progression
c50 cso30:c:InputAssociation connector
c52 cso30:c:InputAssociation connector
c51 cso30:c:OutputProcess connector
p17_propro_p17
PMID: 18325755,16801397
Braf, frequently activated in malignant melanoma, induces cytokine production that contributes to pro-tumor milieu
c53 cso30:c:InputAssociation connector
c54 cso30:c:InputAssociation connector
c55 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 18325755
TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines
c56 cso30:c:InputAssociation connector
c57 cso30:c:OutputProcess connector
p22_propro_p18
PMID: 18325755
TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines
c58 cso30:c:InputAssociation connector
c59 cso30:c:OutputProcess connector
p22_propro_p19
PMID: 18325755
TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines
c60 cso30:c:InputAssociation connector
c61 cso30:c:OutputProcess connector
p22_propro_p20
PMID: 18325755
TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines
c62 cso30:c:InputAssociation connector
c63 cso30:c:OutputProcess connector
p22_propro_p21
PMID: 18325755
TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines
c64 cso30:c:InputAssociation connector
c65 cso30:c:OutputProcess connector
p22_propro_p23
PMID: 18325755
TAM contribute to tumor progression and invasion also by expressing molecules that directly affect tumor cell proliferation and dissolution of connective tissues. These include epidermal growth factor (EGF), members of the FGF family, TGFβ, VEGF, chemokines, and cytokines
PMID: 18325755
TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.
c66 cso30:c:InputAssociation connector
c67 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 18325755
TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.
c68 cso30:c:InputAssociation connector
c69 cso30:c:OutputProcess connector
p24_propro_p25
PMID: 18325755
TAM produce several matrix metalloproteases (e.g. MMP2, MMP9) and activators of MMPs, such as chemokines.
c70 cso30:c:InputAssociation connector
c71 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation
c72 cso30:c:InputAssociation connector
c73 cso30:c:OutputProcess connector
p26_propro_p27
PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation
c74 cso30:c:InputAssociation connector
c75 cso30:c:OutputProcess connector
p26_propro_p28
PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation
c76 cso30:c:InputAssociation connector
c77 cso30:c:OutputProcess connector
p26_propro_p29
PMID: 18325755,7547226
TAM also produce factors, such as TGFβ, PDGF, IL-6, urokinase plasminogen activator, and tissue-type plasminogen activator (t-PA) that may cause matrix degradation
c78 cso30:c:InputAssociation connector
c79 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 18325755
Chemokines have been shown to induce gene expression of various MMPs and, in particular, MMP-9 production, along with the uPA receptor
c80 cso30:c:InputAssociation connector
c81 cso30:c:OutputProcess connector
p31_propro_p31
c82 cso30:c:InputAssociation connector
c84 cso30:c:InputAssociation connector
c83 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 18325755,9192897
In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor
c85 cso30:c:InputAssociation connector
c86 cso30:c:OutputProcess connector
p32_propro_p33
PMID: 18325755,9192897
In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor
c87 cso30:c:InputAssociation connector
c88 cso30:c:OutputProcess connector
p32_propro_p34
PMID: 18325755,9192897
In normal macrophages CCL18 is inducible by Th2 cytokines: IL-4, IL-13, and IL-10 and recruit naive T cells by interacting with an unidentified receptor
c89 cso30:c:InputAssociation connector
c90 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18325755,12401408,15229479
Two other chemokines, CCL17 and CCL22, are abundantly expressed by TAM
c91 cso30:c:InputAssociation connector
c92 cso30:c:OutputProcess connector
p35_propro_p36
PMID: 18325755,12401408,15229479
Two other chemokines, CCL17 and CCL22, are abundantly expressed by TAM
c93 cso30:c:InputAssociation connector
c94 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 18325755,9419219
These chemokines interact with the CCR4 receptor, expressed mostly by Th2 cells and by Treg
c95 cso30:c:InputProcess connector
c96 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p37_propro_p38
PMID: 18325755,9419219
These chemokines interact with the CCR4 receptor, expressed mostly by Th2 cells and by Treg
c99 cso30:c:InputProcess connector
c98 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c100 cso30:c:InputAssociation connector
c101 cso30:c:InputAssociation connector
c102 cso30:c:OutputProcess connector
p39_propro_p40
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c103 cso30:c:InputAssociation connector
c104 cso30:c:InputAssociation connector
c105 cso30:c:OutputProcess connector
p39_propro_p41
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c106 cso30:c:InputAssociation connector
c107 cso30:c:InputAssociation connector
c108 cso30:c:OutputProcess connector
p39_propro_p42
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c109 cso30:c:InputAssociation connector
c110 cso30:c:InputAssociation connector
c111 cso30:c:OutputProcess connector
p39_propro_p43
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c112 cso30:c:InputAssociation connector
c113 cso30:c:InputAssociation connector
c114 cso30:c:OutputProcess connector
p39_propro_p44
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c115 cso30:c:InputAssociation connector
c116 cso30:c:InputAssociation connector
c117 cso30:c:OutputProcess connector
p39_propro_p45
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c118 cso30:c:InputAssociation connector
c119 cso30:c:InputAssociation connector
c120 cso30:c:OutputProcess connector
p39_propro_p46
PMID: 18325755,10702399
In particular, the RET/PTC1 oncogene activated transcriptome profile includes CSFs, which promote leukocyte recruitment and survival; IL-1, a primary inflammatory cytokine; the inflammatory mediator COX2; chemokines attracting monocytes and dendritic cells (CCL2, CCL20; angiogenic chemokines; coordinate induction and inhibition of matrix degrading enzymes and inhibitors; l-selectin; and CXCR4.
c121 cso30:c:InputAssociation connector
c123 cso30:c:InputAssociation connector
c122 cso30:c:OutputProcess connector
TLR4_enti_MO000019394
TLR4
fibronectin_enti_MO000017549
fibronectin
TLR4:fibronectin_enti_e5
TLR4:fibronectin
Hyaluronan_enti_e6
Hyaluronan
TLR4:Hyaluronan_enti_e11
TLR4:Hyaluronan
Hsp60_enti_MO000020119
Hsp60
TLR4:Hsp60_enti_e12
TLR4:Hsp60
NF-kappaB_enti_MO000000058
NF-kappaB
NF-kappaB{active}_enti_e13
NF-kappaB{active}
cytokines_enti_e14
cytokines
ROI_enti_e15
ROI
IL-1_enti_MO000000214
IL-1
TNF_enti_MO000000204
TNF
IL-1R:ligand:MyD88_enti_e16
IL-1R:ligand:MyD88
SIGIRR_enti_MO000066718
SIGIRR
IL-1R:ligand:MyD88:SIGIRR_enti_e17
IL-1R:ligand:MyD88:SIGIRR
IRAK_enti_MO000000213
IRAK
TRAF6_enti_MO000000212
TRAF6
IL-1R:ligand:MyD88:IRAK:TRAF6_enti_e18
IL-1R:ligand:MyD88:IRAK:TRAF6
TLR4:ligand:MyD88_enti_e19
TLR4:ligand:MyD88
TLR4:ligand:MyD88:SIGIRR_enti_e20
TLR4:ligand:MyD88:SIGIRR
TLR4:ligand:MyD88:IRAK:TRAF6_enti_e21
TLR4:ligand:MyD88:IRAK:TRAF6
SIGIRR_enti_G027468
SIGIRR
Ras_enti_MO000016736
Ras
Ras_enti_e22
Ras
IL-8_enti_MO000017264
IL-8
IL-8_enti_e23
IL-8
Braf_enti_e24
Braf
Cytokine_enti_e25
Cytokine
Cytokine_enti_e26
Cytokine
FGF_enti_e30
FGF
TGFbeta_enti_e31
TGFbeta
TGFbeta_enti_MO000016808
TGFbeta
VEGF_enti_G010711
VEGF
EGF_enti_MO000000071
EGF
EGF_enti_G011171
EGF
VEGF_enti_e27
VEGF
FGF_enti_e28
FGF
Chemokines_enti_e29
Chemokines
Chemokines_enti_e32
Chemokines
MMP2_enti_MO000021803
MMP2
MMP2_enti_e33
MMP2
MMP9_enti_MO000021957
MMP9
MMP9_enti_e34
MMP9
PDGF_enti_MO000000098
PDGF
PDGF_enti_e35
PDGF
IL-6_enti_G010262
IL-6
IL-6_enti_MO000007384
IL-6
urokinase plasminogen activator_enti_e36
urokinase plasminogen activator
urokinase plaminogen activator_enti_e37
urokinase plaminogen activator
tPA_enti_G010373
tPA
TPA_enti_MO000020606
TPA
uPAR_enti_e38
uPAR
uPAR_enti_MO000017887
uPAR
IL-4_enti_MO000017053
IL-4
IL-13_enti_MO000007321
IL-13
IL-10_enti_MO000017247
IL-10
CCL18_enti_e39
CCL18
CCL17_enti_e40
CCL17
CCL17_enti_e41
CCL17
CCL22_enti_e42
CCL22
CCL22_enti_e43
CCL22
CCR4_enti_MO000019937
CCR4
CCL17:CCR4_enti_e44
CCL17:CCR4
CCL22:CCR4_enti_e45
CCL22:CCR4
COX-2_enti_MO000017266
COX-2
CCL2_enti_e46
CCL2
CCL20_enti_e47
CCL20
L-selectin_enti_MO000089774
L-selectin
L-selectin_enti_e48
L-selectin
CXCR4_enti_G010586
CXCR4
CXCR4_enti_MO000017157
CXCR4