1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18353649.csml convertedTime:2009.07.01.11:17

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?
Authors Chau TL, Gioia R, Gatot JS, Patrascu F, Carpentier I, Chapelle JP, O'Neill L,Beyaert R, Piette J, Chariot A.
Affiliation Interdisciplinary Cluster for Applied Genoproteomics, University of Liege,Sart-Tilman, 4000 Liege, Belgium.
Abstract The IkappaB kinases (IKKs) IKK-alpha and IKK-beta, and the IKK-related kinasesTBK1 and IKK-epsilon, have essential roles in innate immunity throughsignal-induced activation of NF-kappaB, IRF3 and IRF7, respectively. Althoughthe signaling events within these pathways have been extensively studied, themechanisms of IKK and IKK-related complex assembly and activation remain poorlydefined. Recent data provide insight into the requirement for scaffold proteinsin complex assembly; NF-kappaB essential modulator coordinates some IKKcomplexes, whereas TANK, NF-kappaB-activating kinase-associated protein 1 (NAP1)or similar to NAP1 TBK1 adaptor (SINTBAD) assemble TBK1 and IKK-epsiloncomplexes. The different scaffold proteins undergo similar post-translationalmodifications, including phosphorylation and non-degradative polyubiquitylation.Moreover, increasing evidence indicates that distinct scaffold proteins assembleIKK, and potentially TBK1 and IKK-epsilon subcomplexes, in a stimulus-specificmanner, which might be a mechanism to achieve specificity.
PMID 18353649
Model Abstract

Entity

G010405:A20 G011131:TANK MO000000065:RIP1 MO000000194:RelB MO000000196:p52 MO000000200:p50 MO000000202:p100 MO000000203:NIK MO000000206:TNFR1 MO000000207:TRADD MO000000209:TRAF2 MO000000210:IKK-alpha MO000000211:IKK-beta MO000000212:TRAF6 MO000000213:IRAK MO000000233:IKB-alpha MO000000248:IKK MO000000289:TNF-alpha MO000007694:IRF-3 MO000007702:IRF-7 MO000008179:PKR(DAI) MO000013731:LT-beta MO000016573:MyD88 MO000016574:TAK1 MO000016591:A20 MO000016599:IKK-gamma MO000016608:IKK-i MO000016882:LPS MO000016963:TRAF3 MO000016965:TRAF5 MO000016981:LT-betaR MO000019326:TANK MO000019331:TBK1 MO000019394:TLR4 MO000019398:TLR3 MO000019406:Tollip MO000019479:protein remnants MO000022125:TAB2 MO000022224:dsRNA MO000038687:(TNF-alpha)3:(TNFR1)3 MO000039077:IRAK-4 MO000041125:TRIF MO000041446:dsRNA:TLR3 MO000041541:TAB3 MO000042007:TLR8 MO000042012:TLR9 MO000042126:TLR7 MO000061519:NCKAP1(NAP1) MO000066987:DDX58 MO000068831:MAL MO000080947:RelA-p65 MO000090351:Efp MO000094908:MAVS MO000103999:IFIH1 e1: e10: e100:p52:RelB e101:p52:RelB e102:TANK:TBK1:IKK-i:IKK e103:TANK{p} e104:TANK{p}{ub} e11: e12: e13:LPS:TLR4:TRIF e14:TLR3:dsRNA:TRIF e15:LPS:TLR4:TRIF:TRAF3 e16:viral nucleic acid e17:TLR9:viral nucleic acid e18:TLR8:viral nulceic acid e19:TLR7:viral nucleic acid e2: e20:TANK:TBK1:IKK-i e22:NAP1:TBK1 e23:SINTBAD e24:TBK1:IKK-i:SINTBAD e25:NAP1:TBK1:IKK-i e26:TANK:IRF-7 e27:TANK:IKK-gamma e28:TLR3:dsRNA:TRIF:TRAF3 e29:TLR3:dsRNA:TRIF:TRAF3:NAP1:IKK-i:TBK1 e3: e30:IRF-3{p} e31:IRF-3{p}:IRF-3{p} e32:IRF-3{p}:IRF-3{p} e33:ISRE e34:IRF-3{p}:IRF-3{p}:ISRE e35:IFN inducible genes e37:TLR3:dsRNA:TRIF:TRAF3:RIP1:TRAF6 e38:TLR3:dsRNA:TRIF:TRAF3:RIP1{ub}:TRAF6 e39:TAK1:TAB2 e4: e40:TLR3:dsRNA:TRIF:TRAF3:RIP1{ub}:TRAF6:TAB2:TAK1 e41:IKK{active} e42:p65:p50(NF-KappaB) e44:p65:p50:IKBalpha e45:p65:p50:IKBalpha{p} e46:p65:p50:IKBalpha{p}{ub} e48:p65:p50 e49:proinflammatory genes e5:LPS:TLR4 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:LPS:TLR4:TRIF:TRAF3:TANK:TBK1:IKK-i e64:TLR3:dsRNA:TRIF:TRAF3:RIP1 e65:LPS:TLR4:Tollip e66:LPS:TLR4:Tollip:Mal e67:LPS:TLR4:Tollip:Mal:MyD88 e68:LPS:TLR4:Tollip:Mal:MyD88:IRAK1 e69:LPS:TLR4:Tollip:Mal:MyD88:IRAK1{p} e7: e70:LPS:TLR4:Tollip:Mal:MyD88:IRAK1{p}:TRAF6 e71:TAB2:TAB3:TAK1 e72:LPS:TLR4:Tollip:Mal:MyD88:IRAK1{p}:TRAF6:TAB2:TAB3:TAK1 e74:DDX58:dsRNA e75:IFIH1:dsRNA e76:DDX58{ub}:dsRNA e77:IFIH1{ub}:dsRNA e78:DDX58{ub}:dsRNA:MAVS e79:IFIH1{ub}:dsRNA:MAVS e8: e80:DNA e82:DNA:DAI e83:TRAF3{active} e84:NAP1:TBK1:IKK-i{active} e85:TANK:TBK1:IKK-i{active} e86:TBK1:IKK-i:SINTBAD{active} e87:IRF-7{p} e88:TRAF6{active} e89:IKK-i e9: e90:DNA:DAI:TBK1 e93:RelA-p65{p} e94:p65:p50(NF-KappaB){active} e95:RIP1{ub} e96:A20:NAP1:TBK1:IKK-i e97:p100{p} e98:LT-beta:LT-betaR e99:NIK{active}

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93
Model Detail
751.0, 1039.0
22.0, 22.0

A20

--

G010405

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p78

p79

true true true true

csml-variable:Double

m93378

10

false

infinite

0

unit false false false
TRANSFACG010405

--

Go back
626.0, 1010.0
24.0, 24.0

TANK

--

G011131

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p76

--

true true true true

csml-variable:Double

m94016

10

false

infinite

0

unit false false false
TRANSFACG011131

--

Go back
973.0, 273.0
22.0, 22.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p80

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
835.0, 1315.0
22.0, 22.0

RelB

--

MO000000194

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p88

true true true true

csml-variable:Double

m167

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000000194

--

Go back
988.0, 1224.0
20.0, 20.0

p52

--

MO000000196

cso30:c:Protein

cso30:i:CC_CellComponent

--

p82

p85 p88

true true true true

csml-variable:Double

m168

10

false

infinite

0

unit false false false
TRANSPATHMO000000196

--

Go back
554.0, 474.0
27.5, 27.5

p50

--

MO000000200

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m172

10

false

infinite

0

unit false false false
TRANSPATHMO000000200

--

Go back
992.0, 1176.0
20.0, 20.0

p100

--

MO000000202

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85 p86

true true true true

csml-variable:Double

m173

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
1063.0, 1215.0
22.0, 22.0

NIK

--

MO000000203

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
362.0, 958.0
27.0, 27.0

TNFR1

--

MO000000206

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m177

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000000206

--

Go back
423.0, 1259.0
22.0, 22.0

TRADD

--

MO000000207

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75

true true true true

csml-variable:Double

m178

10

false

infinite

0

unit false false false
InterProIPR000488
TRANSPATHMO000000207

--

Go back
1092.0, 1140.0
20.0, 20.0

TRAF2

--

MO000000209

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87

true true true true

csml-variable:Double

m180

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000209

--

Go back
469.0, 209.0
22.0, 22.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p86

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
470.0, 258.0
24.0, 24.0

IKK-beta

--

MO000000211

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m182

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000211

--

Go back
984.0, 364.0
19.0, 19.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p43 p66 p67

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
447.0, 431.0
18.0, 18.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
563.0, 543.0
22.0, 22.0

IKB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
572.0, 196.0
20.0, 20.0

IKK

--

MO000000248

cso30:c:Protein

cso30:i:CC_CellComponent

--

p27

p28 p46 p68 p90

true true true true

csml-variable:Double

m207

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
307.0, 1003.0
22.0, 22.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
766.0, 482.0
24.0, 24.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17 p37 p59 p60 p61 p71

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
567.0, 407.0
22.0, 22.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p63 p64 p65

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1069.0, 1041.0
29.5, 29.5

PKR(DAI)

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
1304.0, 1188.0
20.0, 20.0

LT-beta

--

MO000013731

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m1451

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000013731

--

Go back
416.0, 328.0
28.0, 28.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
793.0, 153.0
29.0, 29.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p45

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
756.0, 1208.0
20.0, 20.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

p79

p80 p83

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
511.0, 299.0
22.0, 22.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p27

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
881.0, 245.0
21.0, 21.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p11 p12 p74 p85 p92

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
831.0, 27.0
21.5, 21.5

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1091.0, 219.0
21.5, 21.5

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p15 p53 p56 p87

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1148.0, 1228.0
20.0, 20.0

TRAF5

--

MO000016965

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87

true true true true

csml-variable:Double

m1874

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016965

--

Go back
1230.0, 1206.0
24.0, 24.0

LT-betaR

--

MO000016981

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p84

true true true true

csml-variable:Double

m1886

10

false

infinite

0

unit false false false
InterProIPR001368
TRANSPATHMO000016981

--

Go back
632.0, 328.0
20.0, 20.0

TANK

--

MO000019326

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p13 p14 p91 p92

true true true true

csml-variable:Double

m3897

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000019326

--

Go back
747.0, 295.0
22.5, 22.5

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p10 p11 p12 p70 p91

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
831.0, 91.0
21.5, 21.5

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1231.0, 539.0
21.5, 21.5

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
540.0, 156.0
20.0, 20.0

Tollip

--

MO000019406

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m3973

10

false

infinite

0

unit false false false
InterProIPR000008
TRANSPATHMO000019406

--

Go back
423.0, 879.0
26.5, 26.5

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p81

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
832.0, 200.0
20.0, 20.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p45

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
1295.0, 567.0
25.0, 25.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p47 p48

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
360.0, 1080.0
32.0, 32.0

(TNF-alpha)3:(TNFR1)3

--

MO000038687

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

p74 p75

true true true true

csml-variable:Double

m16874

10

false

infinite

0

unit false false false
TRANSPATHMO000038687

--

Go back
426.0, 566.0
19.0, 19.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
995.0, 207.0
22.0, 22.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
1218.0, 486.0
23.5, 23.5

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p4

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
726.0, 538.0
20.0, 20.0

TAB3

--

MO000041541

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m19389

10

false

infinite

0

unit false false false
TRANSPATHMO000041541

--

Go back
1010.0, 650.0
23.5, 23.5

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
1100.0, 564.0
20.5, 20.5

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1051.0, 447.0
22.0, 22.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
713.0, 201.0
23.0, 23.0

NCKAP1(NAP1)

--

MO000061519

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p12

true true true true

csml-variable:Double

m36417

10

false

infinite

0

unit false false false
TRANSPATHMO000061519

--

Go back
1099.0, 775.0
21.0, 21.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
448.0, 152.0
27.0, 27.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
464.0, 408.0
20.0, 20.0

RelA-p65

--

MO000080947

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p74

true true true true

csml-variable:Double

m55295

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000080947

--

Go back
999.0, 923.0
22.0, 22.0

Efp

--

MO000090351

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p50

true true true true

csml-variable:Double

m63891

10

false

infinite

0

unit false false false
TRANSPATHMO000090351

--

Go back
970.0, 878.0
24.0, 24.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
1053.0, 889.0
18.0, 18.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
336.75, 64.99690800911759
941.0979797868855, 1366.4742666505558

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
374.0, 109.0
887.9700014344677, 1249.1241085553218

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
820.5, 1258.0
19.833527745375772, 24.28595234127645

p52:RelB

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p88

p89

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
668.5, 1050.0
19.833527745375772, 24.28595234127645

p52:RelB

--

e101

cso30:c:Complex

cso30:i:CC_Cytosol

--

p89

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
582.0, 312.0
19.676470588235297, 32.794117647058826

TANK:TBK1:IKK-i:IKK

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
588.0, 1260.0
20.0, 20.0

TANK{p}

--

e103

cso30:c:Protein

cso30:i:CC_CellComponent

--

p91 p92

p93

true true true true

csml-variable:Double

m103

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000019326

--

Go back
664.0, 1320.0
20.0, 20.0

TANK{p}{ub}

--

e104

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93

--

true true true true

csml-variable:Double

m104

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000019326

--

Go back
983.2933077958774, 408.0
213.44410520926158, 356.34312479851314

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
983.2933077958774, 408.0
213.44410520926158, 356.34312479851314

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
992.5, 72.0
26.222976692971198, 36.590200036704005

LPS:TLR4:TRIF

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p5

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1228.5, 395.0
27.91172692237108, 38.94659570563406

TLR3:dsRNA:TRIF

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p15

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1074.0, 63.0
23.38235294117647, 38.970588235294116

LPS:TLR4:TRIF:TRAF3

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p12 p36

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1363.0, 617.0
50.912863070539416, 13.576763485477178

viral nucleic acid

--

e16

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p6 p7 p8

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
1075.5, 597.0
21.16447258790201, 25.915680719880022

TLR9:viral nucleic acid

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1046.5, 692.0
22.20146642226295, 27.185469088485256

TLR8:viral nulceic acid

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
1045.5, 487.0
21.01749708381936, 25.73571071488084

TLR7:viral nucleic acid

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p8

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
336.75, 64.99690800911759
941.0979797868855, 1366.4742666505558

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
807.5, 410.0
25.268122591301164, 35.25784547623418

TANK:TBK1:IKK-i

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p36 p57 p90

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
798.5, 268.0
22.3239460089985, 27.33544409265123

NAP1:TBK1

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p10

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
950.5, 298.0
15.0859327832562, 24.4636747836587

SINTBAD

--

e23

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p11

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
872.5, 404.0
23.121673701596627, 32.26280051385576

TBK1:IKK-i:SINTBAD

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11

p58

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
672.5, 320.0
22.63240961644339, 31.580106441548917

NAP1:TBK1:IKK-i

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p16 p55 p83

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
699.5, 521.0
20.723546075654056, 25.37577070488252

TANK:IRF-7

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p13

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
479.5, 366.0
20.282619563406094, 24.835860689885017

TANK:IKK-gamma

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
1230.0, 343.0
23.294117647058822, 38.82352941176471

TLR3:dsRNA:TRIF:TRAF3

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p16 p22

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
1234.0, 635.0
23.294117647058822, 38.82352941176471

TLR3:dsRNA:TRIF:TRAF3:NAP1:IKK-i:TBK1

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p17

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
355.57195959573767, 83.81886760485528
903.4540605954102, 1328.8303474590814

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
822.0, 550.0
24.0, 24.0

IRF-3{p}

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p37 p59 p60 p61 p71

p19 p72

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
688.5, 651.0
18.233127812031316, 22.326278953507735

IRF-3{p}:IRF-3{p}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p19

p18

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
700.5, 807.0
18.233127812031316, 22.326278953507735

IRF-3{p}:IRF-3{p}

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p20

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
615.0, 824.5
54.18944016980632, 11.7410453701247

ISRE

--

e33

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p20

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
711.0, 866.5
53.92131653381332, 15.27770635124711

IRF-3{p}:IRF-3{p}:ISRE

--

e34

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p20

p21

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
700.0, 988.0
36.69550173010381, 19.570934256055363

IFN inducible genes

--

e35

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p21 p72

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
1230.0, 251.0
23.294117647058822, 38.82352941176471

TLR3:dsRNA:TRIF:TRAF3:RIP1:TRAF6

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

p24

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1234.0, 195.0
23.294117647058822, 38.82352941176471

TLR3:dsRNA:TRIF:TRAF3:RIP1{ub}:TRAF6

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p26

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
968.5, 238.0
19.033327778703548, 23.306115647392097

TAK1:TAB2

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
390.3925848478526, 116.75729689739609
833.8128100911807, 1262.9534888739984

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1234.0, 131.0
23.294117647058822, 38.82352941176471

TLR3:dsRNA:TRIF:TRAF3:RIP1{ub}:TRAF6:TAB2:TAK1

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p26

p28

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
602.0, 254.0
20.0, 20.0

IKK{active}

--

e41

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28 p46 p68

p31 p69

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
TRANSPATHMO000000248

--

Go back
515.5, 465.0
20.91134810864856, 25.605732377937013

p65:p50(NF-KappaB)

--

e42

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29 p33

p30

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
510.5, 590.0
22.948063864929342, 32.020554230133975

p65:p50:IKBalpha

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p31 p69 p75

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
542.5, 646.0
22.948063864929342, 32.020554230133975

p65:p50:IKBalpha{p}

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p32

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
488.5, 692.0
22.948063864929342, 32.020554230133975

p65:p50:IKBalpha{p}{ub}

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p33

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
549.5, 843.0
20.91134810864856, 25.605732377937013

p65:p50

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p35 p76 p77 p78

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
535.0, 940.0
53.35640138408304, 28.456747404844293

proinflammatory genes

--

e49

cso30:c:mRNA

cso30:i:CC_NuclearCentromere

--

p35

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
911.5, 82.0
20.25433019074764, 39.201929401447046

LPS:TLR4

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3 p38 p91 p92

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
491.2986425339366, 748.0
393.39686188248913, 356.76773135339386

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
533.7884339476876, 756.454876574375
230.0309397227219, 345.778992194665

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
496.4267208080099, 752.7617869687824
383.14070533434256, 347.2441574158286

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
497.1593034185919, 753.4943695793643
381.67554011317856, 345.778992194665

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
491.2986425339366, 748.0
393.39686188248913, 356.76773135339386

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
491.2986425339366, 748.0
393.39686188248913, 356.76773135339386

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
498.8489707735604, 751.8047022243961
381.67554011317856, 345.778992194665

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
778.4710258820477, 894.5165221163834
24.57727440975765, 22.248901044622762

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
714.0037561508393, 997.0780875978518
69.59534800528206, 63.002104510044916

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
491.2986425339366, 748.0
393.39686188248913, 356.76773135339386

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
983.2933077958774, 408.0
213.44410520926158, 356.34312479851314

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
584.0200693878555, 906.5446318174152
12.458300579849025, 5.998441019927318

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
583.6040514672582, 888.6558612317286
42.6418368612304, 76.75530635021478

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
601.4928220529455, 938.5780117034135
6.656286729557909, 6.65628672955792

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
746.0, 63.0
23.38235294117647, 38.970588235294116

LPS:TLR4:TRIF:TRAF3:TANK:TBK1:IKK-i

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p37

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1230.0, 303.0
23.294117647058822, 38.82352941176471

TLR3:dsRNA:TRIF:TRAF3:RIP1

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

p23

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
648.5, 80.0
26.222976692971198, 36.590200036704005

LPS:TLR4:Tollip

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
502.0, 78.0
23.470588235294123, 39.117647058823536

LPS:TLR4:Tollip:Mal

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p39

p40

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
354.0, 178.0
23.470588235294123, 39.117647058823536

LPS:TLR4:Tollip:Mal:MyD88

--

e67

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p40

p41

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
358.0, 334.0
23.470588235294123, 39.117647058823536

LPS:TLR4:Tollip:Mal:MyD88:IRAK1

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p41

p42

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
358.0, 462.0
23.470588235294123, 39.117647058823536

LPS:TLR4:Tollip:Mal:MyD88:IRAK1{p}

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p42

p43

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
345.0, 71.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
362.0, 542.0
23.470588235294123, 39.117647058823536

LPS:TLR4:Tollip:Mal:MyD88:IRAK1{p}:TRAF6

--

e70

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p43

p44

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
716.5, 613.0
18.8997981280969, 26.371811341530552

TAB2:TAB3:TAK1

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

p44

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
362.0, 642.0
23.470588235294123, 39.117647058823536

LPS:TLR4:Tollip:Mal:MyD88:IRAK1{p}:TRAF6:TAB2:TAB3:TAK1

--

e72

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p44

p46

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
1076.0, 819.0
19.292817679558013, 21.436464088397788

DDX58:dsRNA

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p49

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1156.0, 963.0
19.292817679558013, 21.436464088397788

IFIH1:dsRNA

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p50

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
992.0, 775.0
19.292817679558013, 21.436464088397788

DDX58{ub}:dsRNA

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

p51

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1028.0, 1007.0
19.292817679558013, 21.436464088397788

IFIH1{ub}:dsRNA

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

p52

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
947.5, 719.0
24.66048816296569, 34.40998348320794

DDX58{ub}:dsRNA:MAVS

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p53 p67

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
925.5, 901.0
21.97742705083502, 30.666177280234912

IFIH1{ub}:dsRNA:MAVS

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p52

p56 p66

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
348.0, 92.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1298.0, 1021.5
60.0, 13.0

DNA

--

e80

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p54

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1000.0, 1133.5
60.0, 17.0

DNA:DAI

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p70

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
861.0, 661.0
21.5, 21.5

TRAF3{active}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53 p56

p55 p57 p58

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
870.5, 610.0
22.63240961644339, 31.580106441548917

NAP1:TBK1:IKK-i{active}

--

e84

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p60 p63

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
759.5, 722.0
25.268122591301164, 35.25784547623418

TANK:TBK1:IKK-i{active}

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p57

p61 p64

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
938.5, 394.0
23.121673701596627, 32.26280051385576

TBK1:IKK-i:SINTBAD{active}

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p59 p65

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
659.0, 443.0
22.0, 22.0

IRF-7{p}

--

e87

cso30:c:Protein

cso30:i:CC_CellComponent

--

p63 p64 p65

--

true true true true

csml-variable:Double

m87

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
856.0, 800.0
19.0, 19.0

TRAF6{active}

--

e88

cso30:c:Protein

cso30:i:CC_CellComponent

--

p66 p67

p68

true true true true

csml-variable:Double

m88

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
673.0, 957.0
34.411764705882355, 18.35294117647059

IKK-i

--

e89

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p77

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
356.0, 113.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
867.5, 1115.0
24.652596806753536, 34.39897228849331

DNA:DAI:TBK1

--

e90

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

p71

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
504.0, 1148.0
20.0, 20.0

RelA-p65{p}

--

e93

cso30:c:Protein

cso30:i:CC_CellComponent

--

p74

--

true true true true

csml-variable:Double

m94

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000080947

--

Go back
559.5, 729.0
20.91134810864856, 25.605732377937013

p65:p50(NF-KappaB){active}

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p33 p69 p75

p34

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
626.0, 1146.0
32.20433869839049, 24.68999300209937

RIP1{ub}

--

e95

cso30:c:Protein

cso30:i:CC_Cytosol

--

p80

p75 p81

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
737.0, 678.0
21.441176470588236, 35.73529411764706

A20:NAP1:TBK1:IKK-i

--

e96

cso30:c:Complex

cso30:i:CC_Extracellular

--

p83

p19

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1008.0, 1300.0
20.0, 20.0

p100{p}

--

e97

cso30:c:Protein

cso30:i:CC_CellComponent

--

p86

p82

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
TRANSPATHMO000000202

--

Go back
1232.5, 1268.0
18.793027844770883, 36.3736022802017

LT-beta:LT-betaR

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p84

p87

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
1075.0, 1267.0
22.0, 22.0

NIK{active}

--

e99

cso30:c:Protein

cso30:i:CC_CellComponent

--

p87

p86

true true true true

csml-variable:Double

m99

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000203

--

Go back
900.0, 28.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016882 MO000019394

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 18353649,16822173 These include lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, and double-stranded (ds) RNA, a product of many replicating viruses, which trigger the TLR4- or the TLR3-dependent signaling cascade, respectively

Go back
767.0, 187.0
21.0, 21.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000061519

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c275 : 1
stoichiometry:c31 : 1

m3902*m36417*0.1

nodelay

--

true

0

false

PMID: 18353649,14560022 NAP1, a candidate scaffold protein that was initially identified as a TBK1-interacting protein, shares several structural features with TANK PMID: 18353649,15611223,17142768 Similarly to TANK, NAP1 constitutively binds to TBK1 and is also required for IRF3 phosphorylation through both the TLR3- and the RIG-I-dependent pathways

Go back
896.0, 348.0
19.0, 19.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000016608 MO000019331

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m23*m1599*m3902*0.1

nodelay

--

true

0

false

PMID: 18353649,17568778 SINTBAD is the most recently identified scaffold protein that constitutively binds to TBK1 and IKK-epsilon

Go back
695.0, 247.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000016608 e15 MO000061519

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c276 : 1
stoichiometry:c139 : 1
stoichiometry:c39 : 1

m3902*m1599*m15*m36417*0.1

nodelay

--

true

0

false

PMID: 18353649 The IRF3-activating pathway also involves TRAF3; this connects TRIF to the TBK1?IKK-epsilon heterodimer kinase complex, which is assembled by the scaffold protein NAP1

Go back
647.0, 383.0
21.0, 21.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019326 MO000007702

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m3897*m980*0.1

nodelay

--

true

0

false

PMID: 18353649 Of note, however, IRF7 was also identified as a TANK-interacting protein through yeast two-hybrid analyses, and IRF7 can be phosphorylated by TANK-containing immune complexes in macrophages treated with unmethylated CpG DNA motifs, which are TLR9 ligands

Go back
559.0, 367.0
22.0, 22.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016599 MO000019326

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m1593*m3897*0.1

nodelay

--

true

0

false

PMID: 18353649,17468758 This hypothesis is supported by the physical association between TANK and NEMO

Go back
1088.0, 372.0
19.0, 19.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000016963

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1
stoichiometry:c48 : 1

m14*m1872*0.1

nodelay

--

true

0

false

PMID: 18353649,16621716,16582590,16306937,16306936 TRAF3, which connects TRIF to the TBK1 and IKK-var epsilon kinase complexes for subsequent IRF3 phosphorylation, lies downstream of TRIF

Go back
979.0, 315.0
21.0, 21.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 e28

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1

m25*m28*0.1

nodelay

--

true

0

false

PMID: 18353649 The IRF3-activating pathway also involves TRAF3; this connects TRIF to the TBK1?IKK-epsilon heterodimer kinase complex, which is assembled by the scaffold protein NAP1

Go back
868.0, 476.0
19.0, 19.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e29 MO000007694

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m29*m977*0.1

nodelay

--

true

0

false

PMID: 18353649 IRF3 is phosphorylated (P) within its C-terminal domain by TBK1?IKK-epsilon and forms a homodimer which translocates to the nucleus, binds to ISREs and induces the expression of IFN-dependent genes.

Go back
620.0, 668.0
19.0, 19.0

p18

p18

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e31

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18353649 IRF3 is phosphorylated (P) within its C-terminal domain by TBK1?IKK-epsilon and forms a homodimer which translocates to the nucleus, binds to ISREs and induces the expression of IFN-dependent genes.

Go back
688.0, 564.0
19.0, 19.0

p19

p19

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

e30 e96

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c238 : 1
stoichiometry:c56 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18353649 IRF3 is phosphorylated (P) within its C-terminal domain by TBK1?IKK-epsilon and forms a homodimer which translocates to the nucleus, binds to ISREs and induces the expression of IFN-dependent genes. PMID: 18353649,15258597,15661910 For example, the TNF-alpha-inducible A20 protein negatively regulates both NF-¦ÊB and IRF3-activating pathways by promoting the K48-linked, degradative polyubiquitylation of the receptor-interacting protein (RIP1) in TNF-alpha-stimulated cells or by preventing IRF3 dimerization through direct binding to TBK1 and IKK-var epsilon in dsRNA-stimulated or Newcastle virus-infected cells, respectively

Go back
1296.0, 512.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18353649,16822173 These include lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, and double-stranded (ds) RNA, a product of many replicating viruses, which trigger the TLR4- or the TLR3-dependent signaling cascade, respectively

Go back
638.0, 878.0
23.0, 23.0

p20

p20

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e32 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 18353649 IRF3 is phosphorylated (P) within its C-terminal domain by TBK1?IKK-epsilon and forms a homodimer which translocates to the nucleus, binds to ISREs and induces the expression of IFN-dependent genes.

Go back
723.0, 939.0
21.0, 21.0

p21

p21

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e34

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18353649 IRF3 is phosphorylated (P) within its C-terminal domain by TBK1?IKK-epsilon and forms a homodimer which translocates to the nucleus, binds to ISREs and induces the expression of IFN-dependent genes.

Go back
1020.0, 280.0
19.0, 19.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000000065

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c29 : 1
stoichiometry:c103 : 1

m28*m21*0.1

nodelay

--

true

0

false

PMID: 18353649 RIP1 and TRAF6 are recruited to TRIF, and the signal-induced polyubiquitylated RIP1 is subsequently recruited to the TAB2?TAK1 signaling complex, a crucial step for IKK activation

Go back
1044.0, 312.0
19.0, 19.0

p22

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000212 e64

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c66 : 1

m183*m65*0.1

nodelay

--

true

0

false

PMID: 18353649 RIP1 and TRAF6 are recruited to TRIF, and the signal-induced polyubiquitylated RIP1 is subsequently recruited to the TAB2?TAK1 signaling complex, a crucial step for IKK activation

Go back
1128.0, 260.0
19.0, 19.0

p24

p24

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18353649 RIP1 and TRAF6 are recruited to TRIF, and the signal-induced polyubiquitylated RIP1 is subsequently recruited to the TAB2?TAK1 signaling complex, a crucial step for IKK activation

Go back
901.5, 201.0
20.5, 20.5

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022125 MO000016574

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m6433*m1573*0.1

nodelay

--

true

0

false

PMID: 18353649 RIP1 and TRAF6 are recruited to TRIF, and the signal-induced polyubiquitylated RIP1 is subsequently recruited to the TAB2?TAK1 signaling complex, a crucial step for IKK activation

Go back
927.5, 172.0
20.5, 20.5

p25

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e39 e38

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m39*m38*0.1

nodelay

--

true

0

false

PMID: 18353649 RIP1 and TRAF6 are recruited to TRIF, and the signal-induced polyubiquitylated RIP1 is subsequently recruited to the TAB2?TAK1 signaling complex, a crucial step for IKK activation

Go back
536.0, 244.0
19.0, 19.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000210 MO000000211 MO000016599

MO000000248

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c75 : 1
stoichiometry:c76 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m181*m182*m1593*0.1

nodelay

--

true

0

false

PMID: 18353649 The IKK complex is assembled by NEMO and targets I¦ÊB alpha for phosphorylation and subsequent degradative polyubiquitylation.

Go back
608.0, 144.0
19.0, 19.0

p28

p28

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 MO000000248

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m40*m207*0.1

nodelay

--

true

0

false

PMID: 18353649 RIP1 and TRAF6 are recruited to TRIF, and the signal-induced polyubiquitylated RIP1 is subsequently recruited to the TAB2?TAK1 signaling complex, a crucial step for IKK activation PMID: 18353649 The IKK complex is assembled by NEMO and targets I¦ÊB alpha for phosphorylation and subsequent degradative polyubiquitylation.

Go back
524.0, 412.0
20.0, 20.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000080947 MO000000200

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c156 : 1
stoichiometry:c84 : 1

m55295*m172*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer is then released from I¦ÊB alpha, moves into the nucleus and induces the expression of various proinflammatory genes through binding to ¦ÊB sites

Go back
995.0, 155.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000041125

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m5*m18998*0.1

nodelay

--

true

0

false

PMID: 18353649,12471095,12539043 Both pathways requires Toll?IL-1 receptor (TIR) domain-containing adaptor inducing IFN-¦Â (TRIF) [also called TIR-containing adapter molecule-1 (TICAM-1)] and one of the five TIR-domain-containing adaptors identified so far

Go back
514.0, 550.0
19.0, 19.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000000233

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m43*m199*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer is then released from I¦ÊB alpha, moves into the nucleus and induces the expression of various proinflammatory genes through binding to ¦ÊB sites

Go back
625.0, 605.0
21.0, 21.0

p31

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e41 e44

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m41*m45*0.1

nodelay

--

true

0

false

PMID: 18353649 The IKK complex is assembled by NEMO and targets I¦ÊB alpha for phosphorylation and subsequent degradative polyubiquitylation. PMID: 18353649 TNF-alpha triggers NF-¦ÊB activation through TRADD and the classical, NEMO-dependent pathway, which involves IKK-¦Â-mediated I¦ÊBgreek small letter alpha phosphorylation and subsequent degradation.

Go back
427.0, 651.0
21.0, 21.0

p32

p32

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e45

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 18353649 The IKK complex is assembled by NEMO and targets I¦ÊB alpha for phosphorylation and subsequent degradative polyubiquitylation. PMID: 18353649 TNF-alpha triggers NF-¦ÊB activation through TRADD and the classical, NEMO-dependent pathway, which involves IKK-¦Â-mediated I¦ÊBgreek small letter alpha phosphorylation and subsequent degradation.

Go back
431.0, 807.0
21.0, 21.0

p33

p33

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e46

e42 e94 MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c218 : 1
stoichiometry:c212 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18353649 The IKK complex is assembled by NEMO and targets I¦ÊB alpha for phosphorylation and subsequent degradative polyubiquitylation. PMID: 18353649 TNF-alpha triggers NF-¦ÊB activation through TRADD and the classical, NEMO-dependent pathway, which involves IKK-¦Â-mediated I¦ÊBgreek small letter alpha phosphorylation and subsequent degradation.

Go back
619.0, 715.0
21.0, 21.0

p34

p34

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e94

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c97 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer is then released from I¦ÊB alpha, moves into the nucleus and induces the expression of various proinflammatory genes through binding to ¦ÊB sites PMID: 18353649 The p50?p65 heterodimer translocates into the nucleus to drive the expression of multiple genes, including TANK, IKK-epsilon and A20.

Go back
511.0, 899.0
22.0, 22.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer is then released from I¦ÊB alpha, moves into the nucleus and induces the expression of various proinflammatory genes through binding to ¦ÊB sites

Go back
843.0, 295.0
21.0, 21.0

p5

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 e15

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m20*m15*0.1

nodelay

--

true

0

false

PMID: 18353649,16621716,16582590,16306937,16306936 TRAF3, which connects TRIF to the TBK1 and IKK-var epsilon kinase complexes for subsequent IRF3 phosphorylation, lies downstream of TRIF PMID: 18353649 IRF3 activation also requires TRAF3, which binds to TANK, the scaffold protein that assembles the TBK1?IKK-epsilon heterodimer

Go back
848.0, 448.0
19.0, 19.0

p17

p37

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e63 MO000007694

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m64*m977*0.1

nodelay

--

true

0

false

PMID: 18353649 IRF3 is phosphorylated (P) within its C-terminal domain by TBK1?IKK-epsilon and forms a homodimer which translocates to the nucleus, binds to ISREs and induces the expression of IFN-dependent genes.

Go back
639.0, 175.0
21.0, 21.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019406 e5

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m3973*m5*0.1

nodelay

--

true

0

false

PMID: 18353649 LPS and IKK-mediated NF-¦ÊB activation occurs through the recruitment of Tollip, Mal and Myd88 followed by the binding of the kinase IRAK1 to TLR4

Go back
523.0, 195.0
21.0, 21.0

p38

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e65 MO000068831

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1
stoichiometry:c114 : 1

m66*m43675*0.1

nodelay

--

true

0

false

PMID: 18353649 LPS and IKK-mediated NF-¦ÊB activation occurs through the recruitment of Tollip, Mal and Myd88 followed by the binding of the kinase IRAK1 to TLR4

Go back
1147.0, 415.0
21.0, 21.0

p3

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18353649,12471095,12539043 Both pathways requires Toll?IL-1 receptor (TIR) domain-containing adaptor inducing IFN-¦Â (TRIF) [also called TIR-containing adapter molecule-1 (TICAM-1)] and one of the five TIR-domain-containing adaptors identified so far

Go back
479.0, 331.0
21.0, 21.0

p38

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 MO000016573

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c116 : 1
stoichiometry:c117 : 1

m67*m1572*0.1

nodelay

--

true

0

false

PMID: 18353649 LPS and IKK-mediated NF-¦ÊB activation occurs through the recruitment of Tollip, Mal and Myd88 followed by the binding of the kinase IRAK1 to TLR4

Go back
435.0, 475.0
21.0, 21.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e67 MO000000213

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m68*m184*0.1

nodelay

--

true

0

false

PMID: 18353649 LPS and IKK-mediated NF-¦ÊB activation occurs through the recruitment of Tollip, Mal and Myd88 followed by the binding of the kinase IRAK1 to TLR4

Go back
432.0, 520.0
20.0, 20.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000039077 e68

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c278 : 1
stoichiometry:c121 : 1

m17258*m42*0.1

nodelay

--

true

0

false

PMID: 18353649 IRAK1 is subsequently phosphorylated by IRAK4

Go back
608.0, 492.0
19.0, 19.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000000212

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m69*m183*0.1

nodelay

--

true

0

false

PMID: 18353649 This event triggers the recruitment of TRAF6 to the receptor complex and subsequent signal-induced association of these proteins with the TAB2?TAB3?TAK1 complex, a step required for IKK activation

Go back
444.0, 616.0
19.0, 19.0

p43

p44

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e70 e71

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m70*m71*0.1

nodelay

--

true

0

false

PMID: 18353649 This event triggers the recruitment of TRAF6 to the receptor complex and subsequent signal-induced association of these proteins with the TAB2?TAB3?TAK1 complex, a step required for IKK activation

Go back
716.0, 492.0
19.0, 19.0

p43

p45

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016574 MO000022125 MO000041541

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c130 : 1

m1573*m6433*m19389*0.1

nodelay

--

true

0

false

PMID: 18353649 This event triggers the recruitment of TRAF6 to the receptor complex and subsequent signal-induced association of these proteins with the TAB2?TAB3?TAK1 complex, a step required for IKK activation

Go back
528.0, 344.0
19.0, 19.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e72 MO000000248

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m72*m207*0.1

nodelay

--

true

0

false

PMID: 18353649 This event triggers the recruitment of TRAF6 to the receptor complex and subsequent signal-induced association of these proteins with the TAB2?TAB3?TAK1 complex, a step required for IKK activation

Go back
1167.0, 819.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 MO000022224

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c279 : 1
stoichiometry:c138 : 1

m41844*m119368*0.1

nodelay

--

true

0

false

PMID: 18353649,16039576 Both proteins harbor a DEx(D/H) box RNA helicase domain that is required to sense dsRNA synthesized from replicating virus entering the cytoplasm (e.g. the Sendai virus, the Newcastle disease virus or the vesicular stomatitis virus PMID: 18353649 RNA from viruses triggers the activation of the cytosolic receptors RIG-I and MDA-5 through binding to their DExD/H box RNA helicase

Go back
1102.0, 914.0
19.0, 19.0

p47

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 MO000022224

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c280 : 1
stoichiometry:c141 : 1

m76904*m119368*0.1

nodelay

--

true

0

false

PMID: 18353649,16039576 Both proteins harbor a DEx(D/H) box RNA helicase domain that is required to sense dsRNA synthesized from replicating virus entering the cytoplasm (e.g. the Sendai virus, the Newcastle disease virus or the vesicular stomatitis virus PMID: 18353649 RNA from viruses triggers the activation of the cytosolic receptors RIG-I and MDA-5 through binding to their DExD/H box RNA helicase

Go back
1000.0, 844.0
20.0, 20.0

p49

p49

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e74 MO000090351

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c144 : 1
stoichiometry:c143 : 1

m74*m63891*0.1

nodelay

--

true

0

false

PMID: 18353649 The CARD domains of these receptors subsequently undergo K63-linked polyubiquitylation by the E3 ubiquitin ligase TRIM25, which might facilitate the interaction of RIG-I with the mitochondrial adaptor MAVS.

Go back
1079.0, 155.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000016963

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c13 : 1
stoichiometry:c15 : 1

m13*m1872*0.1

nodelay

--

true

0

false

PMID: 18353649,16621716,16582590,16306937,16306936 TRAF3, which connects TRIF to the TBK1 and IKK-var epsilon kinase complexes for subsequent IRF3 phosphorylation, lies downstream of TRIF

Go back
1120.0, 1008.0
20.0, 20.0

p49

p50

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e75 MO000090351

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c147 : 1
stoichiometry:c146 : 1

m75*m63891*0.1

nodelay

--

true

0

false

PMID: 18353649 The CARD domains of these receptors subsequently undergo K63-linked polyubiquitylation by the E3 ubiquitin ligase TRIM25, which might facilitate the interaction of RIG-I with the mitochondrial adaptor MAVS.

Go back
952.0, 812.0
19.0, 19.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e76 MO000094908

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c152 : 1

m76*m68199*0.1

nodelay

--

true

0

false

PMID: 18353649 The CARD domains of these receptors subsequently undergo K63-linked polyubiquitylation by the E3 ubiquitin ligase TRIM25, which might facilitate the interaction of RIG-I with the mitochondrial adaptor MAVS. PMID: 18353649,16125763 Because they also harbor two caspase-recruitment domain (CARD)-like domains, they can transmit the signal through direct binding to mitochondrial antiviral signaling (MAVS)

Go back
944.0, 960.0
19.0, 19.0

p51

p52

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e77

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c151 : 1
stoichiometry:c153 : 1

m68199*m77*0.1

nodelay

--

true

0

false

PMID: 18353649 The CARD domains of these receptors subsequently undergo K63-linked polyubiquitylation by the E3 ubiquitin ligase TRIM25, which might facilitate the interaction of RIG-I with the mitochondrial adaptor MAVS. PMID: 18353649,16125763 Because they also harbor two caspase-recruitment domain (CARD)-like domains, they can transmit the signal through direct binding to mitochondrial antiviral signaling (MAVS)

Go back
921.0, 645.0
21.0, 21.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e78 MO000016963

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c159 : 1

m78*m1872*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
1071.0, 1095.0
21.0, 21.0

p54

p54

cso30:i:ME_DNABinding

cso30:i:CC_Cytosol

--

e80 MO000008179

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c65 : 1
stoichiometry:c158 : 1

m80*m1055*0.1

nodelay

--

true

0

false

PMID: 18353649 Indeed, the intracellular DNA sensor is DNA-dependent activator of IFN-regulatory factors (DAI), which binds to, and is activated by, DNA from various sources

Go back
939.0, 571.0
21.0, 21.0

p53

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e83 e25

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m83*m25*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
877.0, 993.0
21.0, 21.0

p53

p56

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e79 MO000016963

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m79*m1872*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
777.0, 681.0
21.0, 21.0

p53

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e83 e20

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m83*m20*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
937.0, 489.0
21.0, 21.0

p53

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e83 e24

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m83*m24*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
872.0, 552.0
19.0, 19.0

p59

p59

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e86 MO000007694

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m86*m977*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
1292.0, 612.0
19.0, 19.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000042012

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c20 : 1

m16*m19828*0.1

nodelay

--

true

0

false

PMID: 18353649, 16424890 The TLR7, TLR8 and TLR9 receptors, which, in contrast to TLR4, are not localized on the cell surface but rather in endosomal compartments, sense viral nucleic acids in plasmacytoid dendritic cells and also elicit IFN gene induction through IRF7 phosphorylation

Go back
760.0, 616.0
19.0, 19.0

p59

p60

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e84 MO000007694

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m84*m977*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
840.0, 632.0
19.0, 19.0

p59

p61

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e85 MO000007694

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m85*m977*0.1

nodelay

--

true

0

false

PMID: 18353649 MAVS signals to TRAF3, which triggers IRF3 phosphorylation through TBK1 and IKK-epsilon-mediated activations.

Go back
662.0, 702.0
19.0, 19.0

p63

p63

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e84

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c182 : 1
stoichiometry:c184 : 1
stoichiometry:c183 : 1

m980*m84*0.1

nodelay

--

true

0

false

PMID: 18353649,16153868,16125763 This protein subsequently triggers NF-¦ÊB activation through TRAF6 and the IKK-alpha?beta complex or IRF3 and IRF7 activation through TRAF3 and the TBK1 and IKK-epsilon kinase complexes

Go back
730.0, 586.0
20.0, 20.0

p63

p64

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e85

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c185 : 1
stoichiometry:c181 : 1
stoichiometry:c186 : 1

m980*m85*0.1

nodelay

--

true

0

false

PMID: 18353649,16153868,16125763 This protein subsequently triggers NF-¦ÊB activation through TRAF6 and the IKK-alpha?beta complex or IRF3 and IRF7 activation through TRAF3 and the TBK1 and IKK-epsilon kinase complexes

Go back
704.0, 408.0
20.0, 20.0

p63

p65

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e86

e87

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c187 : 1
stoichiometry:c189 : 1

m980*m86*0.1

nodelay

--

true

0

false

PMID: 18353649,16153868,16125763 This protein subsequently triggers NF-¦ÊB activation through TRAF6 and the IKK-alpha?beta complex or IRF3 and IRF7 activation through TRAF3 and the TBK1 and IKK-epsilon kinase complexes

Go back
915.0, 799.0
22.0, 22.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e79 MO000000212

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m79*m183*0.1

nodelay

--

true

0

false

PMID: 18353649 Of note, MAVS can also signal to TRAF6 for the IKK-alpha?IKK-beta-complex-mediated NF-¦ÊB activation PMID: 18353649,16153868,16125763 This protein subsequently triggers NF-¦ÊB activation through TRAF6 and the IKK-alpha?beta complex or IRF3 and IRF7 activation through TRAF3 and the TBK1 and IKK-epsilon kinase complexes

Go back
853.0, 749.0
22.0, 22.0

p66

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e78 MO000000212

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1
stoichiometry:c195 : 1

m78*m183*0.1

nodelay

--

true

0

false

PMID: 18353649 Of note, MAVS can also signal to TRAF6 for the IKK-alpha?IKK-beta-complex-mediated NF-¦ÊB activation PMID: 18353649,16153868,16125763 This protein subsequently triggers NF-¦ÊB activation through TRAF6 and the IKK-alpha?beta complex or IRF3 and IRF7 activation through TRAF3 and the TBK1 and IKK-epsilon kinase complexes

Go back
664.0, 240.0
19.0, 19.0

p66

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e88 MO000000248

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c198 : 1

m88*m207*0.1

nodelay

--

true

0

false

PMID: 18353649 Of note, MAVS can also signal to TRAF6 for the IKK-alpha?IKK-beta-complex-mediated NF-¦ÊB activation PMID: 18353649,16153868,16125763 This protein subsequently triggers NF-¦ÊB activation through TRAF6 and the IKK-alpha?beta complex or IRF3 and IRF7 activation through TRAF3 and the TBK1 and IKK-epsilon kinase complexes

Go back
590.0, 578.0
19.0, 19.0

p66

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

e41 e44

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c221 : 1
stoichiometry:c200 : 1

m41*m45*0.1

nodelay

--

true

0

false

PMID: 18353649 Of note, MAVS can also signal to TRAF6 for the IKK-alpha?IKK-beta-complex-mediated NF-¦ÊB activation PMID: 18353649,16153868,16125763 This protein subsequently triggers NF-¦ÊB activation through TRAF6 and the IKK-alpha?beta complex or IRF3 and IRF7 activation through TRAF3 and the TBK1 and IKK-epsilon kinase complexes

Go back
1292.0, 680.0
19.0, 19.0

p6

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000042007

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c18 : 1
stoichiometry:c19 : 1
stoichiometry:c21 : 1

m16*m19823*0.1

nodelay

--

true

0

false

PMID: 18353649, 16424890 The TLR7, TLR8 and TLR9 receptors, which, in contrast to TLR4, are not localized on the cell surface but rather in endosomal compartments, sense viral nucleic acids in plasmacytoid dendritic cells and also elicit IFN gene induction through IRF7 phosphorylation

Go back
933.0, 1081.0
21.0, 21.0

p70

p70

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e82 MO000019331

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c203 : 1
stoichiometry:c204 : 1

m82*m3902*0.1

nodelay

--

true

0

false

PMID: 18353649,17618271 DAI subsequently recruits TBK1, which triggers IRF3 phosphorylation and type I IFN gene expression

Go back
798.0, 1066.0
20.0, 20.0

p71

p71

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e90 MO000007694

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1
stoichiometry:c207 : 1

m91*m977*0.1

nodelay

--

true

0

false

PMID: 18353649,17618271 DAI subsequently recruits TBK1, which triggers IRF3 phosphorylation and type I IFN gene expression

Go back
765.0, 905.0
21.0, 21.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18353649,17618271 DAI subsequently recruits TBK1, which triggers IRF3 phosphorylation and type I IFN gene expression

Go back
427.0, 1003.0
21.0, 21.0

p73

p73

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000289 MO000000206

MO000038687

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c83 : 1
stoichiometry:c210 : 1

m230*m177*0.1

nodelay

--

true

0

false

PMID: 18353649,17003035 Additional evidence for crosstalk between the two signaling pathways is provided by IKK-var epsilon-mediated phosphorylation of p65 in TNF-alpha-stimulated cells

Go back
461.0, 1065.0
21.0, 21.0

p74

p74

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000080947 MO000016608 MO000038687

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c136 : 1
stoichiometry:c231 : 1
stoichiometry:c215 : 1

m55295*m1599*m16874*0.1

nodelay

--

true

0

false

PMID: 18353649,17003035 Additional evidence for crosstalk between the two signaling pathways is provided by IKK-var epsilon-mediated phosphorylation of p65 in TNF-alpha-stimulated cells

Go back
478.0, 1194.0
19.0, 19.0

p75

p75

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000207 e44 e95 MO000038687

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c217 : 1
stoichiometry:c230 : 1
stoichiometry:c277 : 1
stoichiometry:c216 : 1

m178*m45*m16874*0.1

nodelay

--

true

0

false

PMID: 18353649 TNF-alpha triggers NF-¦ÊB activation through TRADD and the classical, NEMO-dependent pathway, which involves IKK-¦Â-mediated I¦ÊBgreek small letter alpha phosphorylation and subsequent degradation. PMID: 18353649 For example, the TNF-alpha-inducible A20 protein negatively regulates both NF-¦ÊB and IRF3-activating pathways by promoting the K48-linked, degradative polyubiquitylation of the receptor-interacting protein (RIP1) in TNF-alpha-stimulated cells

Go back
587.0, 939.0
21.0, 21.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

G011131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c222 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer translocates into the nucleus to drive the expression of multiple genes, including TANK, IKK-epsilon and A20.

Go back
667.0, 907.0
21.0, 21.0

p76

p77

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer translocates into the nucleus to drive the expression of multiple genes, including TANK, IKK-epsilon and A20.

Go back
671.0, 1011.0
21.0, 21.0

p76

p78

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e48

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c226 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer translocates into the nucleus to drive the expression of multiple genes, including TANK, IKK-epsilon and A20.

Go back
755.0, 1139.0
21.0, 21.0

p79

p79

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010405

MO000016591

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c228 : 1

m93378*0.1

nodelay

--

true

0

false

PMID: 18353649 The p50?p65 heterodimer translocates into the nucleus to drive the expression of multiple genes, including TANK, IKK-epsilon and A20.

Go back
1172.0, 544.0
19.0, 19.0

p6

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000042126

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m16*m19940*0.1

nodelay

--

true

0

false

PMID: 18353649, 16424890 The TLR7, TLR8 and TLR9 receptors, which, in contrast to TLR4, are not localized on the cell surface but rather in endosomal compartments, sense viral nucleic acids in plasmacytoid dendritic cells and also elicit IFN gene induction through IRF7 phosphorylation

Go back
819.0, 1199.0
21.0, 21.0

p80

p80

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016591 MO000000065

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c229 : 1
stoichiometry:c36 : 1
stoichiometry:c232 : 1

m1585*m21*0.1

nodelay

--

true

0

false

PMID: 18353649 For example, the TNF-alpha-inducible A20 protein negatively regulates both NF-¦ÊB and IRF3-activating pathways by promoting the K48-linked, degradative polyubiquitylation of the receptor-interacting protein (RIP1) in TNF-alpha-stimulated cells

Go back
559.0, 1099.0
21.0, 21.0

p81

p81

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e95

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c214 : 1

m95*0.1

nodelay

--

true

0

false

PMID: 18353649 For example, the TNF-alpha-inducible A20 protein negatively regulates both NF-¦ÊB and IRF3-activating pathways by promoting the K48-linked, degradative polyubiquitylation of the receptor-interacting protein (RIP1) in TNF-alpha-stimulated cells

Go back
1036.0, 1172.0
19.0, 19.0

p82

p82

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

e97

MO000000196

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c243 : 1

m97*0.1

nodelay

--

true

0

false

PMID: 18353649 A second crosstalk is established between IKK-epsilon and p100, an inhibitory molecule whose processing into p52 is triggered following stimulation with lymphotoxin-¦Â PMID: 18353649 p100 is subsequently processed into p52 and moves into the nucleus as a heterodimer with the NF-¦ÊB protein RelB

Go back
589.0, 697.0
21.0, 21.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016591 e25

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c236 : 1
stoichiometry:c237 : 1

m1585*m25*0.1

nodelay

--

true

0

false

PMID: 18353649,15258597,15661910 For example, the TNF-alpha-inducible A20 protein negatively regulates both NF-¦ÊB and IRF3-activating pathways by promoting the K48-linked, degradative polyubiquitylation of the receptor-interacting protein (RIP1) in TNF-alpha-stimulated cells or by preventing IRF3 dimerization through direct binding to TBK1 and IKK-var epsilon in dsRNA-stimulated or Newcastle virus-infected cells, respectively

Go back
1304.0, 1256.0
19.0, 19.0

p84

p84

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000013731 MO000016981

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c239 : 1
stoichiometry:c240 : 1
stoichiometry:c241 : 1

m1451*m1886*0.1

nodelay

--

true

0

false

PMID: 18353649 A second crosstalk is established between IKK-epsilon and p100, an inhibitory molecule whose processing into p52 is triggered following stimulation with lymphotoxin-¦Â

Go back
911.0, 1179.0
21.0, 21.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016608 MO000000202 MO000000196

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c247 : 1

m1599*m173*m168*0.1

nodelay

--

true

0

false

PMID: 18353649 IKK-epsilon expression is also induced in TNF-alpha-stimulated cells, and this kinase associates with p100 and p52 to enhance the transactivation potential of specific p52?p65 heterodimers

Go back
902.0, 1238.0
19.0, 19.0

p86

p86

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000210 MO000000202 e99

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c249 : 1
stoichiometry:c255 : 1
stoichiometry:c250 : 1

m181*m173*m99*0.1

nodelay

--

true

0

false

PMID: 18353649 This pathway, which requires TRAF2 and TRAF5 and is negatively regulated by TRAF3, triggers NIK activation and IKK-alpha-mediated p100 phosphorylation

Go back
1148.0, 1160.0
19.0, 19.0

p87

p87

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e98 MO000016965 MO000000209 MO000000203 MO000016963

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1
stoichiometry:c256 : 1
stoichiometry:c254 : 1

m98*m1874*m180*m174*0.1

nodelay

--

true

0

false

PMID: 18353649 This pathway, which requires TRAF2 and TRAF5 and is negatively regulated by TRAF3, triggers NIK activation and IKK-alpha-mediated p100 phosphorylation.

Go back
923.0, 1315.0
21.0, 21.0

p88

p88

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000196 MO000000194

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c258 : 1
stoichiometry:c259 : 1

m168*m167*0.1

nodelay

--

true

0

false

PMID: 18353649 p100 is subsequently processed into p52 and moves into the nucleus as a heterodimer with the NF-¦ÊB protein RelB

Go back
709.0, 1225.0
21.0, 21.0

p89

p89

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e100

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c261 : 1

m100*0.1

nodelay

--

true

0

false

PMID: 18353649 p100 is subsequently processed into p52 and moves into the nucleus as a heterodimer with the NF-¦ÊB protein RelB

Go back
717.0, 377.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019326 MO000019331 MO000016608

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m3897*m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 18353649,10759890 TANK constitutively binds to IKK-epsilon and TBK1 through its N-terminal domain

Go back
635.0, 283.0
17.0, 17.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 MO000000248

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c263 : 1
stoichiometry:c264 : 1

m20*m207*0.1

nodelay

--

true

0

false

PMID: 18353649 TANK also connects IKK-var epsilon and TBK1 to the IKK complex through binding to NEMO for subsequent p65 phosphorylation

Go back
512.0, 1280.0
19.0, 19.0

p91

p91

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000019326 MO000019331 e5

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1
stoichiometry:c265 : 1

m3897*m3902*m5*0.1

nodelay

--

true

0

false

PMID: 18353649 TBK1 and IKK-var epsilon phosphorylate TANK in macrophages and also are required for LPS-mediated TANK polyubiquitylation, independently of their kinase activity.

Go back
706.0, 1126.0
19.0, 19.0

p91

p92

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016608 e5 MO000019326

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c270 : 1
stoichiometry:c271 : 1
stoichiometry:c274 : 1
stoichiometry:c269 : 1

m1599*m5*m3897*0.1

nodelay

--

true

0

false

PMID: 18353649 TBK1 and IKK-var epsilon phosphorylate TANK in macrophages and also are required for LPS-mediated TANK polyubiquitylation, independently of their kinase activity.

Go back
567.0, 1307.0
21.0, 21.0

p93

p93

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c273 : 1

m103*0.1

nodelay

--

true

0

false

PMID: 18353649 TBK1 and IKK-var epsilon phosphorylate TANK in macrophages and also are required for LPS-mediated TANK polyubiquitylation, independently of their kinase activity.

Go back
853.0, 38.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1173.6568542494924, 441.65685424949237

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
825.0, 323.7104889620336

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
869.7656092540743, 94.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.1283172646318, 109.36299063504812

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1039.0, 291.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1007.9189058818871, 328.1361908439229

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
998.0, 336.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
763.0, 102.0

c106

c106

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.0, 466.2724472327433

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.7851494673247, 467.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
560.0, 168.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1014.0, 229.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.6422871255307, 105.0

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 124.9249690339478

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
550.1026788994519, 109.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 173.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
519.4133125023502, 124.87416965595108

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.78129394354863, 117.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.0, 342.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
382.23944430734275, 217.04551266231854

c117

c117

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
371.0, 217.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
449.79887605359005, 449.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1168.0, 417.1676869865141

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.00561363380984, 379.9249591635357

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
387.7165612572172, 494.34601022525817

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.0, 547.906973581205

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
381.0, 483.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
634.5701659755862, 377.0

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.7672476530251, 504.0

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
729.9284966869867, 182.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
732.9522635832988, 220.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
729.7354436625493, 518.8094964814716

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
385.0, 571.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1093.4632633294639, 183.86504039586868

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.0, 511.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
471.0, 626.0

c131

c131

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
392.2744631916617, 630.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.0, 370.06722019490496

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
543.2767863074105, 216.0

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.0, 280.1601724872445

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
481.64528479831074, 266.0

c136

c136

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1120.0, 793.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1103.0, 830.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.1898088913156, 224.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1019.0, 102.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.0, 903.0

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1121.0, 932.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.616228490282, 833.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1003.9922778767136, 803.9382230137094

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1010.0, 872.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1142.9656235549244, 984.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1055.0, 1018.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1021.0, 942.0

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
976.9322862329901, 795.0

c148

c148

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.2838126928013, 838.6670854686902

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1087.301672079202, 109.99431009885343

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.6079254665552, 902.0

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.9525178510431, 978.95758708444

c151

c151

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.271030765326, 760.9954075771187

c152

c152

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
943.6906911759853, 939.5339352927587

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.6996903666364, 673.5307152332491

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
938.9774620518558, 241.0

c155

c155

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.7120559573644, 439.08665228224123

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1099.6307940059135, 1035.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1048.5857022873224, 1114.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
890.7365962981012, 659.0

c159

c159

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1318.9985211202388, 622.1538177138508

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
897.8065486848079, 932.0

c160

c160

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
893.1326884363071, 241.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
872.3866444113866, 690.990651168656

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
881.0, 598.036844177308

c163

c163

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
695.0, 346.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
899.7008847747089, 589.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
805.7824497174829, 675.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
789.9757119070324, 445.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.6428033978249, 702.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
877.0, 517.3124880008232

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1121.0, 577.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 435.0

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 433.99597180236293

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
889.2973429588436, 426.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.0, 502.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.0, 562.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
787.0, 626.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.435715945279, 506.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
779.0, 579.6568542494924

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
785.0, 657.2636575727674

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
784.0, 506.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1317.3548626638176, 631.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.6208448322876, 581.8340833560568

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.749691655339, 613.806316616128

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
582.0, 429.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.067508144815, 472.99971516057815

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
688.4142813037531, 631.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
588.0, 429.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
678.5539958447581, 472.1672249535955

c186

c186

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
731.9944676154428, 410.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
589.0, 418.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
687.1676940130167, 426.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1034.0, 663.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
927.796029752168, 828.9602975216799

c190

c190

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
929.2350150421889, 383.0

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
883.0, 810.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.7673585722439, 739.0

c193

c193

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
870.5484617733453, 383.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
865.0, 771.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.6010289645783, 266.5653584399832

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
592.0, 211.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
629.7824497174829, 252.0

c198

c198

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
600.3155437337081, 274.0

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
853.0, 52.471529031050636

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1104.9895013078128, 611.4097180157853

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
574.4886870935704, 597.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
580.0, 730.9870028021417

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.8896597015578, 1102.066028676329

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.0, 318.0

c203

c203

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
898.8303694063522, 1099.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.3692975529848, 1088.8406661402685

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 506.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.0, 581.9896921094644

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.2881068349136, 574.0

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.629976047529, 926.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.9842810017353, 691.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.8, 1024.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.0, 1014.0

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.6255299625491, 828.0

c212

c212

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.02511761560123, 428.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.19868357765336, 912.8096296679588

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.0, 1086.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.0, 762.8766374468665

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.4468537264198, 622.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
452.0, 752.0784191224138

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1198.5720815054283, 559.5813914223052

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
443.0, 1219.1676940130167

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
533.0, 591.7788826941525

c221

c221

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 960.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 861.0

c223

c223

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
681.0, 928.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
569.0, 869.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
692.0, 1025.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
762.0, 1061.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 1160.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
776.0, 1212.1055682552917

c229

c229

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1073.0, 467.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.83698803634337, 1163.0

c230

c230

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
392.0, 1079.6994371546484

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
665.7047053669884, 1164.1534890777298

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
586.7008847747089, 1121.3701422443753

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.4832142536907, 725.6048436519278

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
604.7641695155405, 352.0

c236

c236

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
610.0, 697.6279775337206

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
703.5190802411536, 586.7003236643484

c238

c238

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1314.0, 1208.0

c239

c239

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1074.3531602401445, 508.15135438863337

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1254.0, 1226.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1258.7347025773502, 1269.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1020.0, 1198.8128547924575

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1012.4774036933123, 1191.0

c243

c243

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1169.6889582922297, 1185.4817952863177

c244

c244

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
892.0, 266.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
939.9900187110228, 1186.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.9459451369956, 1199.9691115068547

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
485.0, 231.0

c248

c248

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
927.5842074051469, 1193.0

c249

c249

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 344.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.0, 1253.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1158.0, 1187.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1112.0, 1154.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1085.0, 1181.437601569802

c253

c253

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1097.4550114420476, 1179.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
928.8883650844857, 1251.3318018973807

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1103.0, 241.0

c256

c256

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
946.544030462707, 1244.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.0, 1326.0

c258

c258

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
847.068230803076, 1279.747013919703

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.7950595939388, 318.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.6462320697756, 1241.3526867907

c260

c260

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
682.8552865618956, 1081.7818964123953

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.3409919128368, 302.87768608679755

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.0, 216.0

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.5631853341599, 298.0

c264

c264

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
531.0, 1275.035946394237

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.0048536786446, 348.0

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
525.8679010975817, 318.0

c267

c267

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.5572750077215, 121.0

c268

c268

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.2791292043919, 1145.0

c269

c269

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.2341704273326, 265.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
719.5689290811055, 266.0

c270

c270

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
719.5614215284768, 121.0

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
586.0183750985082, 1280.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0, 1319.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 348.0

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 203.23048155891163

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.2654560121236, 88.0

c276

c276

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
392.0, 1111.0

c277

c277

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
378.0, 373.0

c278

c278

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1187.6898372918974, 592.0

c279

c279

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 392.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.9528174517275, 592.0

c280

c280

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.0, 286.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.0, 47.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.0, 215.86804919170356

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.0, 208.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
920.897233121606, 317.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
893.0, 266.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 310.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.6518879601005, 367.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
833.3095287328448, 295.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.8421713081511, 272.4652570302059

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
723.9994123696188, 256.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
690.2172852104175, 268.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1306.2221365379228, 538.9969153652218

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.0, 348.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.0, 399.3711937189796

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 404.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0, 321.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
588.0126284062368, 344.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 378.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1114.8110000001107, 385.7286639344507

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.2441610143323, 241.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1107.0, 365.09527931970325

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.0, 326.2815156786386

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.0, 529.2333107865676

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1003.0, 336.19409903942767

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.0, 322.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
894.2728493241308, 493.3325159727285

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
790.0, 487.6135719910779

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0231486264291, 495.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
714.9699247055655, 563.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 583.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
646.7790984158441, 664.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
635.0, 687.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.1337810613895, 829.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1249.6307940059135, 504.4022870018617

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
643.0, 836.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
661.0, 880.4172239865221

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
735.4204706649821, 882.0

c62

c62

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
723.6906911759853, 960.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1046.5734565841656, 295.5773543349255

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1082.3330443576974, 1071.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1063.0, 275.12447195866395

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1155.0, 270.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.0, 223.67538335099013

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
852.0, 210.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 109.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 174.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0, 217.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.1159660434203, 199.85994340570036

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
955.9563479663227, 183.83458195450936

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 151.83458195450936

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
491.0, 226.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
494.0, 258.85296421844834

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
527.0, 270.38461538461536

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.0, 222.4

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
634.9998263045478, 150.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 184.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
589.0, 169.5631853341599

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.438898430631, 163.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
484.0, 419.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
389.0, 981.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.1984430354239, 432.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
524.271030765326, 491.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.929823205461, 555.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.3805211953236, 569.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
613.0, 274.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
533.0, 607.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 117.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
571.9601774867889, 622.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.0, 662.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
448.0, 669.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.74701391970297, 724.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
445.0, 498.76688876399714

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.0, 869.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
570.8123825158167, 736.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
534.5876987549067, 869.0

c98

c98

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 921.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back