1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18385818.csml convertedTime:2009.07.01.11:17

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Zinc in human health: effect of zinc on immune cells.
Authors Prasad AS.
Affiliation Wayne State University School of Medicine, Detroit, Michigan 48201, UnitedStates of America. prasada@karmanos.org
Abstract Although the essentiality of zinc for plants and animals has been known for manydecades, the essentiality of zinc for humans was recognized only 40 years ago inthe Middle East. The zinc-deficient patients had severe immune dysfunctions,inasmuch as they died of intercurrent infections by the time they were 25 yearsof age. In our studies in an experimental human model of zinc deficiency, wedocumented decreased serum testosterone level, oligospermia, severe immunedysfunctions mainly affecting T helper cells, hyperammonemia, neurosensorydisorders, and decreased lean body mass. It appears that zinc deficiency isprevalent in the developing world and as many as two billion subjects may begrowth retarded due to zinc deficiency. Besides growth retardation and immunedysfunctions, cognitive impairment due to zinc deficiency also has been reportedrecently. Our studies in the cell culture models showed that the activation ofmany zinc-dependent enzymes and transcription factors were adversely affecteddue to zinc deficiency. In HUT-78 (T helper 0 [Th(0)] cell line), we showed thata decrease in gene expression of interleukin-2 (IL-2) and IL-2 receptoralpha(IL-2Ralpha) were due to decreased activation of nuclear factor-kappaB(NF-kappaB) in zinc deficient cells. Decreased NF-kappaB activation in HUT-78due to zinc deficiency was due to decreased binding of NF-kappaB to DNA,decreased level of NF-kappaB p105 (the precursor of NF-kappaB p50) mRNA,decreased kappaB inhibitory protein (IkappaB) phosphorylation, and decreasedIkappa kappa. These effects of zinc were cell specific. Zinc also is anantioxidant and has anti-inflammatory actions. The therapeutic roles of zinc inacute infantile diarrhea, acrodermatitis enteropathica, prevention of blindnessin patients with age-related macular degeneration, and treatment of common coldwith zinc have been reported. In HL-60 cells (promyelocytic leukemia cell line),zinc enhances the up-regulation of A20 mRNA, which, via TRAF pathway, decreasesNF-kappaB activation, leading to decreased gene expression and generation oftumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-8. We have reportedrecently that in both young adults and elderly subjects, zinc supplementationdecreased oxidative stress markers and generation of inflammatory cytokines.
PMID 18385818
Model Abstract

Entity

G010229:IL-2 G010230:IL-2Ralpha G010329:TNF-alpha G010389:IL-1beta G010405:A20 G010453:IFN-gamma MO000000058:NF-kappaB MO000000210:IKK-alpha MO000000233:IkappaB-alpha MO000000289:TNF-alpha MO000016591:A20 MO000016597:IL-1beta MO000016665:IFNgamma MO000016882:LPS MO000017061:IL-2 MO000017214:IL-2Ralpha MO000021432:NADPH oxidase e1: e10: e11:NF-kappaB{active} e12:IkappaB-alpha{p} e13:PMA e14:PHA-p e15:IKK-alpha{p} e16:IkappaB-alpha{ub} e17:NF-kappaB{active} e18:DNA e19:NF-KappaB{active}:DNA e2: e20:p105 e21:O2 e22:O2- e23:Metallothionein e24:Hydroxyl group e25:Iron e26:H2O2 e27:Copper e28:ROS e29:A20:DNA e3: e30:Epstein Barr protein e31:Thymulin e32:High affinity receptors e33:Thymulin:High affinity receptors e34:T-cell marker e35:Super oxide dismutase e36:Thymocytes e37:peripheral T-lymphocytes e38:Peripheral B-lymphocytes e4: e5:Zinc e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:MHC class I e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p5 p6 p7 p8 p9
Model Detail
763.0, 931.0
25.5, 25.5

IL-2

--

G010229

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p38 p39

p3 p33

true true true true

csml-variable:Double

m93218

10

false

infinite

0

unit false false false
TRANSFACG010229

--

Go back
702.0, 974.0
28.0, 28.0

IL-2Ralpha

--

G010230

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p41 p42 p43

p40

true true true true

csml-variable:Double

m93219

10

false

infinite

0

unit false false false
TRANSFACG010230

--

Go back
395.0, 1059.0
25.0, 25.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p23

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
365.0, 997.0
21.5, 21.5

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p24

--

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
594.0, 970.0
20.0, 20.0

A20

--

G010405

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p25 p26 p27 p28 p29 p30

--

true true true true

csml-variable:Double

m93378

10

false

infinite

0

unit false false false
TRANSFACG010405

--

Go back
785.0, 1045.0
22.0, 22.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p1

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
328.0, 744.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p20 p21

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
726.0, 402.0
20.0, 20.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
292.0, 464.0
24.0, 24.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6 p7 p10

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
118.0, 1298.0
20.0, 20.0

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p20 p26

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
543.0, 1039.0
18.0, 18.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
121.0, 1349.0
22.0, 22.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p21 p27

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
1114.0, 802.0
19.0, 19.0

IFNgamma

--

MO000016665

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

--

true true true true

csml-variable:Double

m1639

10

false

infinite

0

unit false false false
InterProIPR002069
TRANSPATHMO000016665

--

Go back
1104.0, 1020.0
24.0, 24.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1117.0, 845.0
22.0, 22.0

IL-2

--

MO000017061

cso30:c:Protein

cso30:i:CC_CellComponent

--

p3 p33

p35 p36 p37

true true true true

csml-variable:Double

m1954

10

false

infinite

0

unit false false false
TRANSPATHMO000017061

--

Go back
1097.0, 945.0
22.0, 22.0

IL-2Ralpha

--

MO000017214

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

--

true true true true

csml-variable:Double

m2080

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000017214

--

Go back
1027.0, 659.0
26.0, 26.0

NADPH oxidase

--

MO000021432

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15

true true true true

csml-variable:Double

m5783

10

false

infinite

0

unit false false false
TRANSPATHMO000021432

--

Go back
166.18064482497323, 221.41250239621422
907.1260678596572, 1317.1470505322213

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
167.92074132768835, 225.54448516594573
879.2829457794812, 1236.903863914764

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
456.0, 672.0
24.0, 24.0

NF-kappaB{active}

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p20 p21

p12

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
424.0, 352.0
24.0, 24.0

IkappaB-alpha{p}

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5 p6 p7

--

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
356.0, 182.0
48.191757779646764, 27.30866274179983

PMA

--

e13

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p6 p8 p10 p28 p38 p41

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
452.0, 184.0
40.773759461732546, 23.10513036164844

PHA-p

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p7 p9 p11 p39 p42

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
682.0, 458.0
20.0, 20.0

IKK-alpha{p}

--

e15

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8 p9

--

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
312.0, 604.0
24.0, 24.0

IkappaB-alpha{ub}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10 p11

--

true true true true

csml-variable:Double

m17

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
568.0, 784.0
24.0, 24.0

NF-kappaB{active}

--

e17

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

p13 p43

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
518.0, 985.5
60.0, 13.0

DNA

--

e18

cso30:c:Dna

cso30:i:CC_Nucleoplasm

--

--

p13 p22

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
478.0, 923.5
60.0, 17.0

NF-KappaB{active}:DNA

--

e19

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p13

--

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
166.18064482497323, 221.41250239621422
907.1260678596572, 1317.1470505322213

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
655.0, 851.0
50.346020761245676, 26.851211072664363

p105

--

e20

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p14

--

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
899.0, 592.0
42.28763666947013, 23.962994112699743

O2

--

e21

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
807.0, 660.0
42.94365012615643, 24.33473507148864

O2-

--

e22

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p15

p34

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
836.0, 553.0
39.133725820016814, 22.175777964676197

Metallothionein

--

e23

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
917.5, 469.0
20.705408840559254, 21.056347973450073

Hydroxyl group

--

e24

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p17

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
758.5, 342.0
19.947182601327498, 20.285270442027965

Iron

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
898.0, 391.0
41.1017661900757, 23.291000841042887

H2O2

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p34

p17

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
826.5, 338.0
19.880525349526906, 20.21748340629854

Copper

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p17

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
545.0, 1289.0
53.41463414634146, 30.26829268292683

ROS

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p18 p19

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
462.0, 1127.5
60.0, 17.0

A20:DNA

--

e29

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p22

p20 p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
184.32316618216618, 239.55502375340723
870.8410251452713, 1280.8620078178346

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
1102.0, 1087.5
27.82048701952104, 17.155966995371305

Epstein Barr protein

--

e30

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p30

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
1119.0, 1175.5
26.32320386395653, 16.232642382773193

Thymulin

--

e31

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
1028.5, 1162.0
22.89279437609842, 35.21968365553603

High affinity receptors

--

e32

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p31

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
1033.5, 1236.0
20.444639333479504, 39.57026967770226

Thymulin:High affinity receptors

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p32 p33

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
645.0, 1140.0
45.77854671280277, 24.41522491349481

T-cell marker

--

e34

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p32

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
941.0, 527.5
22.72, 17.040000000000003

Super oxide dismutase

--

e35

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p34

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1149.5, 667.0
29.168149971596293, 42.685097519409204

Thymocytes

--

e36

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p35

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1261.5, 894.0
29.750426055671277, 43.537208861957964

peripheral T-lymphocytes

--

e37

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p36

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1278.5, 810.0
34.92103768225714, 51.103957583790944

Peripheral B-lymphocytes

--

e38

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p37

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
217.88683069297383, 271.3044361284951
803.7136961236565, 1217.3631830676584

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
587.5, 511.0
25.713034882078805, 26.148849032622508

Zinc

--

e5

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p1 p2 p4 p5 p6 p7 p8 p9 p10 p11 p14 p15 p16 p17 p22 p23 p24 p25 p38 p39 p41 p42

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
326.1979164755333, 726.009619577481
552.1757203651307, 500.7627110201469

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
385.837007315715, 737.8769678341845
322.87369868650103, 485.3388082166516

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
333.39573778383135, 732.6933107923289
537.7800777485356, 487.3953285904509

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
334.4239979707307, 733.7215709792285
535.7235573747362, 485.3388082166516

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
326.1979164755333, 726.009619577481
552.1757203651307, 500.7627110201469

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
326.1979164755333, 726.009619577481
552.1757203651307, 500.7627110201469

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
333.3046751619042, 734.840893788055
535.7235573747362, 485.3388082166516

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
729.2759097402095, 931.6616569574185
34.496905076668334, 31.228777227299783

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
638.789013293037, 1075.618083123374
97.68471775546999, 88.4303760733731

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
326.1979164755333, 726.009619577481
552.1757203651307, 500.7627110201469

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
428.0, 861.0
55.7439446366782, 29.730103806228374

MHC class I

--

e6

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p2

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
456.34262688666706, 948.54443051849
17.486593726968582, 8.41947105372563

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
455.7587000248935, 923.4355754622214
59.852503331802374, 107.7345059972443

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
480.86755508116244, 993.5067988750635
9.3428297883789, 9.342829788378909

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
180.09895823776665, 226.71280625224722
889.6080586498215, 1260.5516403008535

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
183.27717514784487, 248.96032462279496
853.4116110281204, 1239.1536592128305

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
190.7524202413868, 276.2078429933425
849.5153188981565, 1222.902469476066

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
926.0, 802.0
19.0, 19.0

p1

p1

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010453 e5

MO000016665

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1

m93423*m5*0.1

nodelay

--

true

0

false

PMID: 18385818,9280142,9227444 Our studies in the experimental human model showed for the first time that the production of IFN-gamma was decreased, whereas the production of IL-4, IL-6 and IL-10 was not affected due to zinc deficiency

Go back
394.0, 562.0
19.0, 19.0

p10

p10

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000233 e5 e13

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1
stoichiometry:c32 : 1

m199*m5*m14*0.1

nodelay

--

true

0

false

PMID: 18385818,11574819 Zinc deficiency caused a 50% reduction of ubiquitinated IKappaB-alpha after PMA/PHA-p stimulation

Go back
450.0, 578.0
19.0, 19.0

p10

p11

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e14 e5

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c37 : 1

m15*m5*0.1

nodelay

--

true

0

false

PMID: 18385818,11574819 Zinc deficiency caused a 50% reduction of ubiquitinated IKappaB-alpha after PMA/PHA-p stimulation

Go back
586.0, 674.0
19.0, 19.0

p12

p12

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e11

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
497.0, 849.0
21.0, 21.0

p13

p13

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

e17 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m18*m19*0.1

nodelay

--

true

0

false

PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
689.0, 793.0
21.0, 21.0

p14

p14

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
910.0, 662.0
19.0, 19.0

p15

p15

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000021432 e21 e5

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m5783*m22*0.1

nodelay

--

true

0

false

PMID: 18385818 The NADPH oxidases are a group of plasma membrane associated enzymes, which catalyze the production of O2.¡Ý from oxygen by using NADPH as the electron donor. PMID: 18385818 Zinc is an inhibitor of this enzyme

Go back
751.0, 555.0
17.0, 17.0

p16

p16

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e5

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18385818 Zinc is known to induce the production of metallothionein, which is very rich in cysteine, and is an excellent scavenger of .OH

Go back
815.0, 427.0
17.0, 17.0

p17

p17

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e26 e25 e27 e5

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c52 : 1

m27*m26*m28*0.1

nodelay

--

true

0

false

PMID: 18385818 Iron and copper ions catalyze the production of .OH from H2O2. PMID: 18385818 Zinc is known to compete with both iron and copper for binding to cell membrane, thus decreasing the production of .OH

Go back
438.0, 1294.0
19.0, 19.0

p18

p18

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000000289

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 18385818,3500253,2824615 A few investigators have reported that inflammatory cytokines such as TNF-alpha (tumor necrosis factor-alpha) and IL-1beta, generated by activated monocytes-macrophages, also are known to produce increased amounts of ROS

Go back
442.0, 1342.0
19.0, 19.0

p18

p19

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000016597

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m1591*0.1

nodelay

--

true

0

false

PMID: 18385818,3500253,2824615 A few investigators have reported that inflammatory cytokines such as TNF-alpha (tumor necrosis factor-alpha) and IL-1beta, generated by activated monocytes-macrophages, also are known to produce increased amounts of ROS

Go back
446.0, 798.0
19.0, 19.0

p2

p2

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18385818 IFN- gamma is the major component of the Th1 response panel, and it upregulates major histocompatibility complex class I antigen expression.

Go back
330.0, 1246.0
19.0, 19.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000289 MO000000058 e29

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c69 : 1
stoichiometry:c62 : 1

m230*m11*0.1

nodelay

--

true

0

false

PMID: 18385818,2118515,1381359,9928991,8557994, One such inhibitor of NF-KappaB activation is A20, a zinc finger-transactivating factor which also binds to DNA, producing the A20 protein which inhibits TNF-alpha-induced NF-KappaB activation

Go back
277.0, 1169.0
21.0, 21.0

p21

p21

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016597 MO000000058 e29

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c70 : 1
stoichiometry:c66 : 1

m1591*m11*0.1

nodelay

--

true

0

false

PMID: 18385818, 2118515,1381359,9928991,8557994 A20 plays an important role in reducing IL-1beta- and TNF-alpha-induced NF-kappaB activation

Go back
481.0, 1037.0
21.0, 21.0

p22

p22

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

MO000016591 e18 e5

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c67 : 1
stoichiometry:c75 : 1
stoichiometry:c68 : 1

m1585*m19*m5*0.1

nodelay

--

true

0

false

PMID: 18385818, 2118515,1381359,9928991,8557994, One such inhibitor of NF-KappaB activation is A20, a zinc finger-transactivating factor which also binds to DNA, producing the A20 protein which inhibits TNF-alpha-induced NF-KappaB activation. PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation

Go back
427.0, 1003.0
21.0, 21.0

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c71 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18385818 Our data showed that zinc supplementation to normal healthy subjects inhibits the induction of TNF-alpha and IL-1beta mRNA in MNCs

Go back
413.0, 941.0
21.0, 21.0

p23

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c73 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18385818 Our data showed that zinc supplementation to normal healthy subjects inhibits the induction of TNF-alpha and IL-1beta mRNA in MNCs

Go back
590.0, 866.0
19.0, 19.0

p25

p25

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation

Go back
570.0, 1066.0
19.0, 19.0

p26

p26

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000000289

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m230*0.1

nodelay

--

true

0

false

PMID: 18385818,8557994 A20 is expressed in various types of cells in response to a number of stimuli such as TNF-alpha, IL-1beta, LPS (lipopolysaccharide), PMA, Epstein-Barr virus latent membrane protein, as well as other stimuli

Go back
594.0, 1134.0
19.0, 19.0

p26

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016597

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m1591*0.1

nodelay

--

true

0

false

PMID: 18385818,8557994 A20 is expressed in various types of cells in response to a number of stimuli such as TNF-alpha, IL-1beta, LPS (lipopolysaccharide), PMA, Epstein-Barr virus latent membrane protein, as well as other stimuli

Go back
562.0, 890.0
19.0, 19.0

p26

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18385818,8557994 A20 is expressed in various types of cells in response to a number of stimuli such as TNF-alpha, IL-1beta, LPS (lipopolysaccharide), PMA, Epstein-Barr virus latent membrane protein, as well as other stimuli

Go back
690.0, 1014.0
19.0, 19.0

p25

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016882

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m155666*0.1

nodelay

--

true

0

false

PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation

Go back
881.0, 845.0
21.0, 21.0

p3

p3

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010229

MO000017061

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1

m93218*0.1

nodelay

--

true

0

false

PMID: 18385818 Because zinc deficiency affects IL-2 production and T-cell activation adversely, we have investigated the role of zinc on NF-KappaB (nuclear factor-kappaB) activation in HUT-78, a T helper 0 (Th0) human malignant lymphoblastoid cell line.

Go back
650.0, 1074.0
19.0, 19.0

p25

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010405

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18385818,15451058 In addition, we provided evidence to show that, in the human pro-myelocytic leukemia cell line HL-60 which differentiates to the monocyte-macrophage phenotype by PMA, zinc increased the expression of A20 and the binding of A20 transactivating factor to DNA, thereby enhancing inhibition of induced NF-KappaB activation

Go back
1122.0, 1230.0
19.0, 19.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 e32

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m32*m33*0.1

nodelay

--

true

0

false

PMID: 18385818 Thymulin binds to high-affinity receptors on T cells, induces several T-cell markers, and promotes T-cell function, including allogenic cytotoxicity, suppressor functions, and interleukin-2 (IL-2) production.

Go back
734.0, 1142.0
19.0, 19.0

p32

p32

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m34*0.1

nodelay

--

true

0

false

PMID: 18385818 Thymulin binds to high-affinity receptors on T cells, induces several T-cell markers, and promotes T-cell function, including allogenic cytotoxicity, suppressor functions, and interleukin-2 (IL-2) production.

Go back
918.0, 934.0
19.0, 19.0

p33

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010229 e33

MO000017061

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c95 : 1
stoichiometry:c94 : 1

m93218*m34*0.1

nodelay

--

true

0

false

PMID: 18385818 Thymulin binds to high-affinity receptors on T cells, induces several T-cell markers, and promotes T-cell function, including allogenic cytotoxicity, suppressor functions, and interleukin-2 (IL-2) production.

Go back
770.0, 502.0
19.0, 19.0

p34

p34

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e35 e22

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m36*m23*0.1

nodelay

--

true

0

false

PMID: 18385818 The dismutation of O2.¡Ýto H2O2 is catalyzed by an enzyme super oxide dismutase (SOD), which contains both copper and zinc.

Go back
1155.0, 771.0
17.0, 17.0

p35

p35

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000017061 e36

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1

m1954*m37*0.1

nodelay

--

true

0

false

PMID: 18385818,7548205 IL-2 also is involved in the differentiation of thymocytes, peripheral T- and B-lymphocytes and other cells of hematopoietic origin

Go back
1151.0, 907.0
17.0, 17.0

p35

p36

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000017061 e37

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m1954*m38*0.1

nodelay

--

true

0

false

PMID: 18385818,7548205 IL-2 also is involved in the differentiation of thymocytes, peripheral T- and B-lymphocytes and other cells of hematopoietic origin

Go back
1199.0, 827.0
17.0, 17.0

p35

p37

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000017061 e38

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m1954*m39*0.1

nodelay

--

true

0

false

PMID: 18385818,7548205 IL-2 also is involved in the differentiation of thymocytes, peripheral T- and B-lymphocytes and other cells of hematopoietic origin

Go back
753.0, 869.0
21.0, 21.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e13 e5

G010229

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c107 : 1
stoichiometry:c106 : 1

m14*m5*0.1

nodelay

--

true

0

false

PMID: 18385818,12389026 Following PMA/PHA-p stimulation, the IL-2 production and IL-2 mRNA were significantly greater in zinc-sufficient cells in comparison to the zinc-deficient cells

Go back
785.0, 857.0
21.0, 21.0

p38

p39

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 e14

G010229

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m5*m15*0.1

nodelay

--

true

0

false

PMID: 18385818,12389026 Following PMA/PHA-p stimulation, the IL-2 production and IL-2 mRNA were significantly greater in zinc-sufficient cells in comparison to the zinc-deficient cells

Go back
328.0, 672.0
23.0, 23.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e5 MO000000058

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1

m5*m11*0.1

nodelay

--

true

0

false

PMID: 18385818,11574819 We showed for the first time that, in zinc deficient HUT-78 cells, the activation of NF-KappaB was affected adversely

Go back
905.0, 893.0
21.0, 21.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010230

MO000017214

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m93219*0.1

nodelay

--

true

0

false

PMID: 18385818,12389026 Similar results were seen for soluble IL-2 receptor alpha (soluble IL-2Ralpha) production and gene expression

Go back
629.0, 921.0
21.0, 21.0

p41

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 e13

G010230

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c114 : 1
stoichiometry:c113 : 1

m5*m14*0.1

nodelay

--

true

0

false

--

Go back
693.0, 901.0
21.0, 21.0

p41

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e5 e14

G010230

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c117 : 1
stoichiometry:c115 : 1

m5*m15*0.1

nodelay

--

true

0

false

--

Go back
654.0, 886.0
19.0, 19.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e17

G010230

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18385818,9619918,2785715 Induction of IL-2Ralphagene expression also is mediated by the induced nuclear expression of NF-KappaB

Go back
294.0, 522.0
19.0, 19.0

p5

p5

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e5 MO000000233

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c13 : 1
stoichiometry:c14 : 1

m5*m199*0.1

nodelay

--

true

0

false

PMID: 18385818 Zinc deficiency caused a 60percent decrease in phosphorylated IKappaB-alpha in non-stimulated and 40percent decrease in phorbol-12 myristate 13 acetate (PMA)/phytohemagglutinin-p (PHA-p)?stimulated cells, compared with zinc-sufficient cells PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
314.0, 382.0
19.0, 19.0

p5

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e13 e5 MO000000233

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m14*m5*m199*0.1

nodelay

--

true

0

false

PMID: 18385818 Zinc deficiency caused a 60percent decrease in phosphorylated IKappaB-alpha in non-stimulated and 40percent decrease in phorbol-12 myristate 13 acetate (PMA)/phytohemagglutinin-p (PHA-p)?stimulated cells, compared with zinc-sufficient cells PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
506.0, 390.0
19.0, 19.0

p5

p7

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14 e5 MO000000233

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m15*m5*m199*0.1

nodelay

--

true

0

false

PMID: 18385818 Zinc deficiency caused a 60percent decrease in phosphorylated IKappaB-alpha in non-stimulated and 40percent decrease in phorbol-12 myristate 13 acetate (PMA)/phytohemagglutinin-p (PHA-p)?stimulated cells, compared with zinc-sufficient cells PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
551.0, 403.0
17.0, 17.0

p8

p8

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e13 MO000000210 e5

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1
stoichiometry:c28 : 1
stoichiometry:c25 : 1

m14*m181*m5*0.1

nodelay

--

true

0

false

PMID: 18385818 Zinc deficiency decreased IKK- alpha in PMA/PHA-p?stimulated cells by 30percent in comparison to zinc-sufficient cells. PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
635.0, 371.0
17.0, 17.0

p8

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000210 e5 e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1
stoichiometry:c27 : 1

m181*m5*m15*0.1

nodelay

--

true

0

false

PMID: 18385818 Zinc deficiency decreased IKK- alpha in PMA/PHA-p?stimulated cells by 30percent in comparison to zinc-sufficient cells. PMID: 18385818,11574819 We showed that the phosphorylation of IKappaB and IKK, translocation of NF-KappaB, and its binding to DNA in HUT-78 cells were all zinc dependent

Go back
802.0, 827.9325740807054

c1

c1

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 703.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.0, 710.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.0, 867.0

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1176.0, 916.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1139.0, 839.9402850002907

c103

c103

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1224.0, 836.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
387.0, 209.0

c105

c105

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 890.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
606.0, 537.0

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
477.0, 207.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
781.0431289826962, 878.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 684.0

c11

c11

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.0, 912.0799186106573

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
926.0, 907.0

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
601.0, 537.0

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
650.0, 939.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.0, 209.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
706.0, 922.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 537.0

c116

c116

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
476.0, 207.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
669.0, 905.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 808.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.9966170230935, 524.0

c12

c12

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
304.0, 488.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
312.0, 382.28456741667384

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
329.18013413435926, 209.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.2165947742446, 399.45264534297195

c16

c16

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.0, 368.96033308110543

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
307.0, 408.78244971748296

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 207.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
945.0, 812.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
526.4824749416337, 415.6262673050237

c20

c20

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
316.0, 406.69571320046646

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
455.3000745961196, 372.2724472327433

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
391.0, 209.0

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 412.0

c24

c24

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 415.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
659.5476811172091, 385.65188796010045

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 388.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
565.6538830249572, 427.54697985222197

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.0, 395.64353983444505

c29

c29

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 535.0

c3

c3

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.0, 207.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
316.0, 487.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.00462147221435, 577.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.7689109332881, 527.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
381.0, 209.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.25862485653334, 207.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
476.28502689044586, 530.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
343.828398279894, 590.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.0, 684.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
583.1313708498985, 693.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.61049379437804, 537.0

c4

c4

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0057081353821, 807.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.3108949951844, 877.6589662697542

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
508.0, 870.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
605.0, 537.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
686.6518879601005, 814.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.0, 672.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
920.0, 616.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
858.0, 672.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
613.0, 530.0

c48

c48

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
613.0, 527.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 817.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.0, 564.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
839.5544289069752, 410.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
832.0, 439.0

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.0, 362.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
826.1474325785512, 358.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 441.45690202245345

c55

c55

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
138.0, 1304.1066571864492

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.0, 1304.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
143.0, 1352.2139702483978

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
461.0, 1317.925218979384

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 868.8441746598661

c6

c6

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
138.0, 1259.9402850002907

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 768.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
342.0, 703.8071514241906

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
510.0, 1048.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
142.0, 1196.0605795342178

c64

c64

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
289.9898412975476, 768.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 703.5183473879075

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
507.72800111696034, 999.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 1058.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.14196668891014, 1145.0

c69

c69

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
902.0, 856.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.90697737268755, 1142.0

c70

c70

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
418.6587841009661, 1024.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
443.25512665525093, 537.0

c72

c72

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
390.20633098764773, 962.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
430.52023512610896, 537.0

c74

c74

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
495.6141076907701, 537.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 537.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
600.0, 885.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
138.0, 1084.6565509320192

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
583.0, 997.7611400011626

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 537.0

c8

c8

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
143.0, 1152.3237900516244

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.0, 998.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
384.0, 209.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
576.0, 909.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.9983597418984, 1024.1619920960384

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
621.3025460151594, 988.266928480466

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.9969295883132, 1084.2216239146876

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
612.8425169829246, 997.0167701427321

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1132.0, 1192.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 1188.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
357.8241185082028, 532.0

c9

c9

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1061.8782684705434, 1242.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
760.5621254794911, 1157.610413421746

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
699.0, 1152.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
789.0, 944.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 864.2150882610083

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
933.8060862248782, 960.4917207701935

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
796.924725494039, 514.0948633906238

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.2633072606727, 528.6731636398415

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.0, 418.93777818477434

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1133.0, 795.2299027111483

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back