1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18385944.csml convertedTime:2009.07.01.11:18

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Regulation of phagocyte migration and recruitment by Src-family kinases.
Authors Baruzzi A, Caveggion E, Berton G.
Affiliation Department of Pathology, Section of General Pathology, University of Verona,Strada Le Grazie 8, 37134, Verona, Italy.
Abstract Src-family kinases (SFKs) regulate different granulocyte and monocyte/macrophageresponses. Accumulating evidence suggests that members of this family areimplicated in signal transduction pathways regulating phagocytic cell migrationand recruitment into inflammatory sites. Macrophages with a genetic deficiencyof SFKs display marked alterations in cytoskeleton dynamics, polarization andmigration. This same phenotype is found in cells with either a lack of SFKsubstrates and/or interacting proteins such as Pyk2/FAK, c-Cbl and p190RhoGAP.Notably, SFKs and their downstream targets also regulate monocyte recruitmentinto inflammatory sites. Depending on the type of assay used, neutrophilmigration in vitro may be either dependent on or independent of SFKs. Alsoneutrophil recruitment in in vivo models of inflammation may be regulateddifferently by SFKs depending on the tissue involved. In this review we willdiscuss possible mechanisms by which SFKs may regulate phagocytic cell migratoryabilities.
PMID 18385944
Model Abstract

Entity

MO000000030:PI3K MO000000044:Vav MO000000085:Src MO000000136:Src family MO000000143:Fyn MO000000144:Lyn MO000000314:GPCR MO000006538:Hck MO000008301:Syk MO000012555:PSGL-1 MO000016852:Pyk2 MO000016872:c-Cbl MO000016886:SHP-2 MO000016997:cortactin MO000016998:actin MO000017157:CXCR4 MO000017281:CCR5 MO000017529:paxillin MO000017852:WASP MO000019001:SDF-1 MO000019573:CAP MO000019632:Arp2/3 complex MO000019718:Cdc42:GTP MO000019719:Cdc42:GDP MO000019951:MIP-1beta MO000036287:p190RhoGAP MO000064543:CR3 MO000066771:TYROBP MO000089777:FGR e1: e10: e100:Fyn: c-Cbl{p} e101:Src family: c-Cbl e102:Src family: c-Cbl{p} e103:Src family: c-Cbl{p}: Pyk2 e104:ligand:beta1-integrin: Hck e105:ligand:beta1-integrin e106:ligand:beta1-integrin: Fgr e107:E selectin e108:E selectin: PSGL-1 e109:c-Cbl: Cap e11:ligand: FCgammaR: ITAM containing adaptor{pT}: Src family e110:PSGL-1:SELE:moesin: ezrin:SFK: Syk e111:PSGL-1:SELE: moesin{p}: ezrin{p}:SFK: Syk e12:ligand: FCgammaR: ITAM containing adaptor: Src family e13:ligand: c-Fms: Src family e14:ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk e15:ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk{p} e16:ligand: GPCR e17:ligand: GPCR: Src family e18:c-Cbl: PI3K e19:ligand: c-Fms: Src family: c-Cbl: PI3K e2: e21:PSGL-1: SELE: Naf1 e22:PSGL-1: SELE: Naf1: Src family e23:PSGL-1: SELE: Naf1{p}: Src family e24:PSGL-1: SELE: Naf1{p}: Src family: PI3K e26:chemokine: chemokine receptor: beta-arrestin e27:chemokine: chemokine receptor: beta-arrestin: Src family e28:ligand: beta2-integrin:DAp-12 e29:ligand: beta3-integrin: DAP-12 e3: e30:ligand: beta2-integrin: DAP-12: Src family e31:ligand: beta3-integrin: DAP-12: Src family e32:ligand: beta2-integrin: DAP-12{p}: Src family e33:ligand: beta3-integrin: DAP-12{p}: Src family e34:ligand: beta2-integrin: DAP-12{p}: Src family: Syk e35:ligand: beta3-integrin: DAP-12{p}: Src family: Syk e36:chemokine: CCR3 e37:chemokine: CXCR1 e38:chemokine: CCR3: Hck: FGR e39:chemokine: CXCR1: Hck: FGR e4: e40:chemoattrcatant: uPAR e41:chemoattrcatant: uPAR: FGR: fyn: Lyn: Hck: CR3 e42:chemoattractant e43:Shc: Lyn: p85:p110: PI3K e44:Shc: Lyn: p85:p110: PI3K{activated} e45:SDF-1: CXCR4 e46:SDF-1: CXCR4: Lyn: PI3K e47:SDF-1: CXCR4: SHP-2: c-Cbl: Fyn e48:chemoattractant: chemoattractant receptor e49:chemoattractant: chemoattractant receptor: Fyn e5:ligand: c-Fms e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:ligand: FCgammaR: ITAM containing adaptor e60: e61: e62: e63:chemoattractant: chemoattractant receptor: Fyn: Fyn e64:chemoattractant: chemoattractant receptor: Fyn: Fyn e65:chemoattractant receptor e66:MIP-1beta: CCR5 e67:MIP-1beta: CCR5: SyK e68:FGR: Pyk2 e69:Src: Pyk2 e7: e70:Src: c-Cbl e71:Lyn: c-Cbl e72:Pyk2: p190RhoGAP e73:Vav{p} e74:FGR: Pyk2{p} e75:Pyk2{p} e76:Src: c-Cbl{p} e77:Lyn: c-Cbl{p} e78:Src family: Pyk2:c-Cbl: p190RhoGAP e79:p190RhoGAP{p} e8: e80:Rac: GDP e81:Rac:GTP e82:WASP e83:actin polymer e84:paxillin{p} e85:c-Cbl: Syk e86:ROI e87:P selectin e88:P selectin: PSGL-1 e89:ligand: beta2-integrin e9: e90:LFA-1: GPCR e91:LFA-1 e92:proinflammatory mediator e93:superoxide anion e94:counter receptor for leukocyte e95:cortactin: Arp2/3 complex e96:cortactin {p} e97:Fyn: c-Cbl e98:Pyk2: c-Cbl e99:Pyk2: c-Cbl{p}

Process

p1 p10 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p8 p9
Model Detail
505.0, 197.0
30.0, 30.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p25 p30

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
519.0, 406.0
30.0, 30.0

Vav

--

MO000000044

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41 p42 p49 p50

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000044

--

Go back
704.0, 296.0
23.5, 23.5

Src

--

MO000000085

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p38

true true true true

csml-variable:Double

m77

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000085

--

Go back
394.0, 374.0
33.0, 33.0

Src family

--

MO000000136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p5 p6 p8 p13 p14 p15 p41 p54 p62 p71

true true true true

csml-variable:Double

m122

10

false

infinite

0

unit false false false
TRANSPATHMO000000136

--

Go back
955.980788664734, 437.30444483807764
27.95269943872323, 29.020249771340026

Fyn

--

MO000000143

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p27 p29 p67

true true true true

csml-variable:Double

m127

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000143

--

Go back
978.9446748522761, 502.3470391846894
26.02492706363887, 27.018853235385542

Lyn

--

MO000000144

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p25 p39

true true true true

csml-variable:Double

m128

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
284.0, 575.0
33.0, 33.0

GPCR

--

MO000000314

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p60

true true true true

csml-variable:Double

m249

10

false

infinite

0

unit false false false
TRANSPATHMO000000314

--

Go back
970.4390814778666, 184.12778303983532
31.32630109512086, 32.52269370926037

Hck

--

MO000006538

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21 p22 p44 p48 p51 p66 p75

true true true true

csml-variable:Double

m751

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000006538

--

Go back
376.0, 504.0
31.0, 31.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p18 p19 p35 p42 p56

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
279.0, 372.0
30.0, 30.0

PSGL-1

--

MO000012555

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p77

true true true true

csml-variable:Double

m1347

10

false

infinite

0

unit false false false
TRANSPATHMO000012555

--

Go back
794.0, 286.0
28.0, 28.0

Pyk2

--

MO000016852

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p37 p44 p68 p74

true true true true

csml-variable:Double

m1785

10

false

infinite

0

unit false false false
TRANSPATHMO000016852

--

Go back
929.0, 845.0
30.0, 30.0

c-Cbl

--

MO000016872

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p38 p39 p56 p68 p67 p71 p78

true true true true

csml-variable:Double

m1795

10

false

infinite

0

unit false false false
InterProIPR000449
TRANSPATHMO000016872

--

Go back
978.0, 890.0
28.0, 28.0

SHP-2

--

MO000016886

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m1807

10

false

infinite

0

unit false false false
InterProIPR000242
TRANSPATHMO000016886

--

Go back
950.0, 1254.0
28.5, 28.5

cortactin

--

MO000016997

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64 p65 p66

true true true true

csml-variable:Double

m1899

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000016997

--

Go back
779.0, 996.0
28.5, 28.5

actin

--

MO000016998

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m1900

10

false

infinite

0

unit false false false
TRANSPATHMO000016998

--

Go back
1110.0, 683.0
32.0, 32.0

CXCR4

--

MO000017157

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m2033

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017157

--

Go back
471.0, 103.0
34.0, 34.0

CCR5

--

MO000017281

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m2134

10

false

infinite

0

unit false false false
InterProIPR000276
TRANSPATHMO000017281

--

Go back
434.0, 218.0
28.0, 28.0

paxillin

--

MO000017529

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54

true true true true

csml-variable:Double

m2323

10

false

infinite

0

unit false false false
InterProIPR001179
TRANSPATHMO000017529

--

Go back
719.0, 892.0
28.5, 28.5

WASP

--

MO000017852

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51 p52

true true true true

csml-variable:Double

m2602

10

false

infinite

0

unit false false false
InterProIPR000697
TRANSPATHMO000017852

--

Go back
1227.0, 684.0
29.0, 29.0

SDF-1

--

MO000019001

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m3609

10

false

infinite

0

unit false false false
InterProIPR001811
TRANSPATHMO000019001

--

Go back
1037.0, 1113.0
30.5, 30.5

CAP

--

MO000019573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p78

true true true true

csml-variable:Double

m4118

10

false

infinite

0

unit false false false
TRANSPATHMO000019573

--

Go back
952.0, 1288.0
24.0, 24.0

Arp2/3 complex

--

MO000019632

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p64

true true true true

csml-variable:Double

m4169

10

false

infinite

0

unit false false false
TRANSPATHMO000019632

--

Go back
478.0, 346.0
28.0, 28.0

Cdc42:GTP

--

MO000019718

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m4251

10

false

infinite

0

unit false false false
TRANSPATHMO000019718

--

Go back
475.0, 303.0
34.0, 34.0

Cdc42:GDP

--

MO000019719

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

--

true true true true

csml-variable:Double

m4252

10

false

infinite

0

unit false false false
TRANSPATHMO000019719

--

Go back
474.0, 2.0
28.0, 28.0

MIP-1beta

--

MO000019951

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34

true true true true

csml-variable:Double

m4479

10

false

infinite

0

unit false false false
InterProIPR000827
TRANSPATHMO000019951

--

Go back
723.0, 716.0
29.0, 29.0

p190RhoGAP

--

MO000036287

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p47 p48 p72

true true true true

csml-variable:Double

m14714

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000036287

--

Go back
1106.9970825455548, 384.26953143921554
25.54298396986778, 26.51850410139692

CR3

--

MO000064543

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m39415

10

false

infinite

0

unit false false false
TRANSPATHMO000064543

--

Go back
344.0, 1028.0
28.0, 28.0

TYROBP

--

MO000066771

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m41628

10

false

infinite

0

unit false false false
TRANSPATHMO000066771

--

Go back
977.2585124155775, 285.1983081055368
28.916585626265412, 30.02094803931727

FGR

--

MO000089777

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p21 p22 p36 p47 p52 p65 p76

true true true true

csml-variable:Double

m63359

10

false

infinite

0

unit false false false
TRANSPATHMO000089777

--

Go back
251.89995765212967, 73.15421481573475
903.4842276592849, 1361.9607218440512

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
264.6714496370636, 141.09705924883667
844.1503976578786, 1232.833755295443

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
582.625, 603.5
26.208590234960838, 32.092151308115305

Fyn: c-Cbl{p}

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p70

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
509.875, 648.5
28.114929344833914, 39.23013396953569

Src family: c-Cbl

--

e101

cso30:c:Complex

cso30:i:CC_Cytosol

--

p71

p73

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
510.625, 695.5
27.539535077487088, 33.72187968671888

Src family: c-Cbl{p}

--

e102

cso30:c:Complex

cso30:i:CC_Cytosol

--

p73

p74

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
508.875, 739.5
29.472242613323544, 41.12405946045146

Src family: c-Cbl{p}: Pyk2

--

e103

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p55 p72

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
1106.625, 127.5
33.94113481086485, 41.560573237793704

ligand:beta1-integrin: Hck

--

e104

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p75

--

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1113.625, 82.5
28.478545242459585, 34.871688051991335

ligand:beta1-integrin

--

e105

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p75 p76

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
967.875, 69.5
32.25, 45.0

ligand:beta1-integrin: Fgr

--

e106

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p76

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
120.5, 345.375
32.73286467486818, 21.27636203866432

E selectin

--

e107

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p77

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
247.625, 335.5
27.359898350274957, 33.501916347275454

E selectin: PSGL-1

--

e108

cso30:c:Complex

cso30:i:CC_Extracellular

--

p77

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
960.625, 1165.5
31.00979003499417, 37.97117147142143

c-Cbl: Cap

--

e109

cso30:c:Complex

cso30:i:CC_Cytosol

--

p78

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
259.875, 689.5
32.25, 45.0

ligand: FCgammaR: ITAM containing adaptor{pT}: Src family

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

p3

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
251.875, 277.5
32.10795558818131, 44.80179849513672

PSGL-1:SELE:moesin: ezrin:SFK: Syk

--

e110

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p12

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
251.875, 221.5
32.25, 45.0

PSGL-1:SELE: moesin{p}: ezrin{p}:SFK: Syk

--

e111

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p12

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
255.875, 637.5
32.25, 45.0

ligand: FCgammaR: ITAM containing adaptor: Src family

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p2

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
265.875, 903.5
27.578317122407782, 38.48137272894109

ligand: c-Fms: Src family

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p5

p7

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
259.875, 741.5
32.25, 45.0

ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
259.875, 793.5
32.25, 45.0

ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk{p}

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
243.625, 490.5
29.27874520913181, 35.851524745875686

ligand: GPCR

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p6

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
244.875, 449.5
26.560332171040557, 37.06092861075427

ligand: GPCR: Src family

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p57

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
401.625, 901.5
28.11110648225296, 34.42176303949341

c-Cbl: PI3K

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p7

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
264.875, 946.5
32.25, 45.0

ligand: c-Fms: Src family: c-Cbl: PI3K

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
251.89995765212967, 73.15421481573475
903.4842276592849, 1361.9607218440512

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
253.625, 178.5
29.099108481919682, 35.63156140643226

PSGL-1: SELE: Naf1

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p8

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
256.875, 122.5
30.616489264085153, 42.72068269407231

PSGL-1: SELE: Naf1: Src family

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p9

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
331.875, 105.5
32.77082951000183, 45.72673885116536

PSGL-1: SELE: Naf1{p}: Src family

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p9

p10

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
375.875, 80.5
39.9598550192696, 55.75793723619013

PSGL-1: SELE: Naf1{p}: Src family: PI3K

--

e24

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

p60 p61

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
796.375, 85.5
23.25, 45.0

chemokine: chemokine receptor: beta-arrestin

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p13

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
839.875, 73.5
32.25, 45.0

chemokine: chemokine receptor: beta-arrestin: Src family

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
265.625, 1060.5
30.560698216963843, 37.42126312281286

ligand: beta2-integrin:DAp-12

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p59

p14

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
263.625, 1251.5
28.478545242459585, 34.871688051991335

ligand: beta3-integrin: DAP-12

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p15

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
269.9696422053153, 91.9140043728154
867.3448585529134, 1324.4411427298912

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
265.875, 1106.5
29.472242613323544, 41.12405946045146

ligand: beta2-integrin: DAP-12: Src family

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p16

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
264.875, 1290.5
25.960589098917232, 36.22407781244265

ligand: beta3-integrin: DAP-12: Src family

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

p17

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
264.875, 1155.5
28.935630390897412, 40.37529821985685

ligand: beta2-integrin: DAP-12{p}: Src family

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

p18

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
263.875, 1333.5
33.607313268489634, 46.89392549091577

ligand: beta3-integrin: DAP-12{p}: Src family

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p19

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
262.875, 1197.5
32.25, 45.0

ligand: beta2-integrin: DAP-12{p}: Src family: Syk

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
262.875, 1385.5
32.25, 45.0

ligand: beta3-integrin: DAP-12{p}: Src family: Syk

--

e35

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
1109.527283787853, 178.62603736989223
28.433879583087414, 36.146702225976824

chemokine: CCR3

--

e36

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p20

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1108.5633976003107, 278.69586416761643
29.11860659816696, 37.01716464204768

chemokine: CXCR1

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p21

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1101.875, 227.5
32.25, 45.0

chemokine: CCR3: Hck: FGR

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
1103.9849382094856, 326.7293810305241
31.08532954823532, 45.0314220589759

chemokine: CXCR1: Hck: FGR

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
303.39855862870894, 124.74363609770627
800.4870257061266, 1258.781879280108

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
1103.7439666625999, 428.8006043642028
31.865385083945803, 40.50901962145835

chemoattrcatant: uPAR

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p22

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1102.057165834401, 480.8369142990194
36.173990579071415, 52.40305510661886

chemoattrcatant: uPAR: FGR: fyn: Lyn: Hck: CR3

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1243.7481162073516, 612.7739728654968
33.31251648157641, 22.480097426805106

chemoattractant

--

e42

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p23 p32

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
1060.4294907077983, 541.8913792012443
31.08532954823532, 45.0314220589759

Shc: Lyn: p85:p110: PI3K

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p23

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
1060.2850354579668, 601.9332752798788
31.08532954823532, 45.0314220589759

Shc: Lyn: p85:p110: PI3K{activated}

--

e44

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p23

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1114.625, 731.5
31.099608398600232, 38.08115314114314

SDF-1: CXCR4

--

e45

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

p25 p27

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1113.875, 784.5
32.25, 45.0

SDF-1: CXCR4: Lyn: PI3K

--

e46

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p25

p26

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1113.875, 836.5
32.25, 45.0

SDF-1: CXCR4: SHP-2: c-Cbl: Fyn

--

e47

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p27

p28

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1118.375, 932.5
23.25, 45.0

chemoattractant: chemoattractant receptor

--

e48

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p29

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1113.875, 988.5
32.25, 45.0

chemoattractant: chemoattractant receptor: Fyn

--

e49

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p29

p30

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
265.625, 849.5
28.73983502749542, 35.191634727545406

ligand: c-Fms

--

e5

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
532.7874517724399, 1077.3567826966607
272.6685584057884, 256.7243889123527

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
562.2376871309795, 1083.4407774953265
159.43748107898995, 248.81706687193116

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
536.3417905226084, 1080.7832889141766
265.55988090545145, 249.87137647732058

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
536.849553201204, 1081.3104437168713
264.54435554826034, 248.81706687193116

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
532.7874517724399, 1077.3567826966607
272.6685584057884, 256.7243889123527

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
532.7874517724399, 1077.3567826966607
272.6685584057884, 256.7243889123527

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
536.849553201204, 1081.3104437168713
264.54435554826034, 248.81706687193116

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
731.8304217818796, 1182.7877432356147
17.03483335068869, 16.009955561239835

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
687.1473060654747, 1256.589415612882
48.237454466573354, 45.33531303175018

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
532.7874517724399, 1077.3567826966607
272.6685584057884, 256.7243889123527

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
254.875, 598.5
25.621260781794824, 35.75059643971371

ligand: FCgammaR: ITAM containing adaptor

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
597.0538967883073, 1191.4429797982211
8.635012600349974, 4.316382816982538

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
596.765549275474, 1178.5705048140562
29.55562006541784, 55.231898478567025

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
609.164492327308, 1214.4936908163763
4.613560205333512, 4.789758133642666

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
1109.875, 1040.5
32.25, 45.0

chemoattractant: chemoattractant receptor: Fyn: Fyn

--

e63

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p30

p31

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1113.875, 1096.5
32.25, 45.0

chemoattractant: chemoattractant receptor: Fyn: Fyn

--

e64

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p33

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
1114.375, 892.5
24.0408611599297, 36.98594024604568

chemoattractant receptor

--

e65

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p32

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
534.625, 90.5
35.639518413597735, 43.64022662889518

MIP-1beta: CCR5

--

e66

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p34

p35

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
599.875, 81.5
32.25, 45.0

MIP-1beta: CCR5: SyK

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p35

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
776.625, 337.5
30.691343109481757, 37.5812364605899

FGR: Pyk2

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p36

p40 p43

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
704.625, 413.5
27.849816697217136, 34.10181636393934

Src: Pyk2

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
263.7075634495214, 112.87423503474261
783.0068270275593, 1151.8737290909505

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
703.875, 459.5
24.05877225178932, 33.57037988621766

Src: c-Cbl

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p45

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
703.875, 554.5
24.39020921269958, 34.032850064231965

Lyn: c-Cbl

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p46

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
706.625, 793.5
28.829653391101484, 35.30161639726712

Pyk2: p190RhoGAP

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p40

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
524.0, 467.5
32.64, 24.479999999999997

Vav{p}

--

e73

cso30:c:Protein

cso30:i:CC_Cytosol

--

p41 p42

--

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
754.5, 391.0
27.043492751208134, 33.1144809198467

FGR: Pyk2{p}

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

--

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
874.5, 203.125
35.56, 26.669999999999995

Pyk2{p}

--

e75

cso30:c:Protein

cso30:i:CC_Cytosol

--

p44

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
587.875, 453.5
32.25, 45.0

Src: c-Cbl{p}

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
586.875, 555.5
24.327078363002386, 33.94476050651495

Lyn: c-Cbl{p}

--

e77

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
567.875, 848.5
32.25, 45.0

Src family: Pyk2:c-Cbl: p190RhoGAP

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p72

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
717.5, 846.125
36.84, 27.629999999999995

p190RhoGAP{p}

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

p47 p48

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
272.382539137401, 136.09356790895046
776.4652515216869, 1170.485485052766

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
653.5, 306.125
37.800000000000004, 28.349999999999998

Rac: GDP

--

e80

cso30:c:Protein

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
655.5, 345.125
40.67999999999999, 30.51

Rac:GTP

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
716.5, 941.125
33.64, 25.229999999999997

WASP

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

p51 p52

p53

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
779.5, 1044.5
26.0, 26.0

actin polymer

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
532.5, 228.125
31.400000000000002, 23.55

paxillin{p}

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

p54

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
914.625, 1114.5
34.48004499250125, 42.22046325612398

c-Cbl: Syk

--

e85

cso30:c:Complex

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
633.5, 249.25
37.10260723296888, 21.02481076534903

ROI

--

e86

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p57

p63

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
117.5, 376.375
34.982425307557115, 22.738576449912127

P selectin

--

e87

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p58

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
247.625, 407.5
27.359898350274957, 33.501916347275454

P selectin: PSGL-1

--

e88

cso30:c:Complex

cso30:i:CC_Extracellular

--

p58

p59

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
269.625, 999.5
23.848816863856023, 29.20263289451758

ligand: beta2-integrin

--

e89

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p59

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
282.0214010128228, 152.10474019658633
772.9202617305948, 1155.1348612134236

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
245.625, 535.5
26.46988001999667, 32.41209798366938

LFA-1: GPCR

--

e90

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p60

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
113.5, 557.375
31.291739894551842, 20.3396309314587

LFA-1

--

e91

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p60

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
657.5, 1268.0
45.0, 24.0

proinflammatory mediator

--

e92

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p61

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
512.5, 1285.25
38.515559293523964, 21.82548359966358

superoxide anion

--

e93

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
604.5, 1197.0
36.22837370242215, 19.32179930795848

counter receptor for leukocyte

--

e94

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p63

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
947.875, 1317.5
32.25, 45.0

cortactin: Arp2/3 complex

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
945.5, 1206.125
36.84, 27.629999999999995

cortactin {p}

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p65 p66

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
702.625, 603.5
27.53953507748709, 33.72187968671888

Fyn: c-Cbl

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p70

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
703.5, 509.0
24.15297450424929, 29.57507082152975

Pyk2: c-Cbl

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

p68

p69

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
590.625, 508.5
25.939135144142643, 31.762206298950176

Pyk2: c-Cbl{p}

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p69

--

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
339.0, 603.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000000136

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m122*0.1

nodelay

--

true

0

false

PMID: 18385944, 8132624, 8327512, 9581795 Because SFKs have been reported to associate with Fcg receptors [135?138], this association may represent the mechanism dictating proximity between SFKs and ITAM-containing adaptors.

Go back
383.0, 171.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e23 MO000000030

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m23*m27*0.1

nodelay

--

true

0

false

PMID: 18395944, 17632516 PSGL-1, the major leukocyte ligand for endothelial selectins, implicates SFKs for phosphorylation of its associated molecule Naf1 which in turn binds PI3-kinase.

Go back
323.0, 287.0
25.0, 25.0

p12

p12

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e110

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c220 : 1

m113*0.1

nodelay

--

true

0

false

PMID: 18385944, 12387735 PSGL-1 also triggers phosphorylation of ezrin and moesin, two ITAM-containing molecules associated with its cytoplasmic tail [20]; it is conceivable that ezrin and moesin phosphorylation is mediated by SFKs.

Go back
795.0, 167.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000136 e26

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m122*m26*0.1

nodelay

--

true

0

false

PMID: 18385944 Receptors for chemokines bind SFKs in phagocytes likely via binding to beta-arrestin. PMID: 18385944 As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.

Go back
348.0, 1066.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000136 e28

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m122*m29*0.1

nodelay

--

true

0

false

PMID: 18385944 In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain. PMID: 18385944 As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.

Go back
341.0, 1256.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000136 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c39 : 1
stoichiometry:c40 : 1

m122*m30*0.1

nodelay

--

true

0

false

PMID: 18385944 In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain. PMID: 18385944 As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.

Go back
347.0, 1116.0
23.0, 23.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m31*0.1

nodelay

--

true

0

false

--

Go back
342.0, 1297.0
23.0, 23.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e31

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m32*0.1

nodelay

--

true

0

false

--

Go back
346.0, 1163.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000008301 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m1066*m33*0.1

nodelay

--

true

0

false

PMID: 18385944 In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain.

Go back
342.0, 1343.0
25.0, 25.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000008301 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m1066*m34*0.1

nodelay

--

true

0

false

PMID: 18385944 In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain.

Go back
334.0, 646.0
27.0, 27.0

p2

p2

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e12

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18385944 Syk binds to phosphorylated tyrosine residues of ITAM-containing adaptors and is phosphorylated and activated by SFKs.

Go back
1032.1277974805662, 188.1305761117443
22.169382313470148, 23.01606016347657

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000006538 MO000089777

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c57 : 1
stoichiometry:c53 : 1

m37*m751*m63359*0.1

nodelay

--

true

0

false

PMID: 18385944, 10527858, 10973280, 7535337 Receptors for chemokines (CCR3, CXCR1) directly [15] or indirectly [16] interacts with Fgr and Hck in granulocytes and the urokinase plasminogen-activator-receptor, a powerful chemoattractant, forms a membrane signaling complex containing the Srcfamily kinases, Fgr, Fyn, Lyn and Hck, as well as b2 integrins, in monocytes [6].

Go back
1027.3083665428553, 287.1997046414913
24.097154688554507, 25.017456699431058

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e37 MO000089777 MO000006538

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c58 : 1
stoichiometry:c56 : 1

m38*m63359*m751*0.1

nodelay

--

true

0

false

PMID: 18385944, 10527858, 10973280, 7535337 Receptors for chemokines (CCR3, CXCR1) directly [15] or indirectly [16] interacts with Fgr and Hck in granulocytes and the urokinase plasminogen-activator-receptor, a powerful chemoattractant, forms a membrane signaling complex containing the Srcfamily kinases, Fgr, Fyn, Lyn and Hck, as well as b2 integrins, in monocytes [6].

Go back
1027.3083665428553, 439.3058413740321
24.097154688554507, 25.017456699431058

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000006538 MO000089777 e40 MO000000143 MO000000144 MO000064543

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c61 : 1
stoichiometry:c65 : 1

m751*m63359*m41*m127*m128*m39415*0.1

nodelay

--

true

0

false

PMID: 18385944, 10527858, 10973280, 7535337 Receptors for chemokines (CCR3, CXCR1) directly [15] or indirectly [16] interacts with Fgr and Hck in granulocytes and the urokinase plasminogen-activator-receptor, a powerful chemoattractant, forms a membrane signaling complex containing the Srcfamily kinases, Fgr, Fyn, Lyn and Hck, as well as b2 integrins, in monocytes [6]. PMID: 18385944, 7535337 The first strong evidence suggesting a link between a chemoattractant receptor, b2 integrins and SFKs in regulating mononuclear phagocyte migration derives from studies showing that the urokinase type plasminogen activator-receptor (uPA-R), the b2 integrins LFA-1 and CR3, and the SFK members Hck, Fgr, Lyn nd Fyn form a large molecular complex in human monocytes [6].

Go back
1139.155278110206, 610.3973144790508
26.02492706363887, 27.018853235385542

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e43 e42

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c68 : 1
stoichiometry:c67 : 1

m45*m43*0.1

nodelay

--

true

0

false

PMID: 18385944, 8810279, 7650013 Neutrophil stimulation with chemoattractants activates a Lyn/Shc/p85-p110 phosphatidylinositol 3-kinase pathway (PI-3K) [93, 94].

Go back
1176.0, 685.0
27.0, 27.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017157 MO000019001

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m2033*m3609*0.1

nodelay

--

true

0

false

PMID: 18385944, 12208881 Interaction of the chemokine Stromal cell-derived factor (SDF/CXCL12) with its receptor (CXCR4) triggers a signalling pathway implicatingLyn and PI-3K in HL-60 cells and hematopoietic progenitors and SDF-induced cell migration is defective in Lyndeficient bone marrow cells [99].

Go back
1040.0, 737.0
27.0, 27.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000144 e45 MO000000030

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c74 : 1

m128*m44*m27*0.1

nodelay

--

true

0

false

PMID: 18385944, 12208881 Interaction of the chemokine Stromal cell-derived factor (SDF/CXCL12) with its receptor (CXCR4) triggers a signalling pathway implicatingLyn and PI-3K in HL-60 cells and hematopoietic progenitors and SDF-induced cell migration is defective in Lyndeficient bone marrow cells [99].

Go back
1195.0, 792.0
30.0, 30.0

p26

p26

cso30:i:CE_CellMigration

cso30:i:CC_Extracellular

--

e46

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18385944, 12208881 Interaction of the chemokine Stromal cell-derived factor (SDF/CXCL12) with its receptor (CXCR4) triggers a signalling pathway implicatingLyn and PI-3K in HL-60 cells and hematopoietic progenitors and SDF-induced cell migration is defective in Lyndeficient bone marrow cells [99].

Go back
1041.0, 846.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 MO000000143 MO000016886 MO000016872

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m44*m127*m1807*m1795*0.1

nodelay

--

true

0

false

PMID: 18385944, 11157475 SDF/CXCL12-induced cell migration in CXCR4 expressing pre-B lymphoma cells involves formation of complexes between CXCR4, the tyrosine phosphatase SHP2, Cbl and Fyn [102].

Go back
1195.0, 844.0
30.0, 30.0

p28

p28

cso30:i:CE_CellMigration

cso30:i:CC_Extracellular

--

e47

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1

m48*0.1

nodelay

--

true

0

false

PMID: 18385944, 11157475 SDF/CXCL12-induced cell migration in CXCR4 expressing pre-B lymphoma cells involves formation of complexes between CXCR4, the tyrosine phosphatase SHP2, Cbl and Fyn [102].

Go back
1045.0, 942.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000143 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m127*m49*0.1

nodelay

--

true

0

false

PMID: 18385944, 15955842 Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].

Go back
346.0, 698.0
27.0, 27.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e11 MO000008301

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m11*m1066*0.1

nodelay

--

true

0

false

PMID: 18385944 Syk binds to phosphorylated tyrosine residues of ITAM-containing adaptors and is phosphorylated and activated by SFKs.

Go back
1044.0, 997.0
27.0, 27.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000030 e49

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m27*m63*0.1

nodelay

--

true

0

false

PMID: 18385944, 15955842 Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].

Go back
1040.0, 1049.0
27.0, 27.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18385944, 15955842 Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].

Go back
1198.0, 898.0
27.0, 27.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e42 e65

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m43*m66*0.1

nodelay

--

true

0

false

PMID: 18385944, 15955842 Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].

Go back
1211.0, 1100.0
30.0, 30.0

p33

p33

cso30:i:CE_CellMigration

cso30:i:CC_Extracellular

--

e64

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 18385944, 15955842 Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].

Go back
538.0, 2.0
27.0, 27.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019951 MO000017281

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1
stoichiometry:c97 : 1

m4479*m2134*0.1

nodelay

--

true

0

false

PMID: 18385944, 10747947 MIP-1b/CCL4-CCR5 interaction induces formation of a signaling complex which includes Syk [109].

Go back
538.0, 162.0
27.0, 27.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e66 MO000008301

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c98 : 1
stoichiometry:c100 : 1

m67*m1066*0.1

nodelay

--

true

0

false

PMID: 18385944, 10747947 MIP-1b/CCL4-CCR5 interaction induces formation of a signaling complex which includes Syk [109].

Go back
879.0, 287.0
25.0, 25.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016852 MO000089777

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c103 : 1
stoichiometry:c102 : 1

m1785*m63359*0.1

nodelay

--

true

0

false

PMID: 18385944, 10547366, 15561106, 11149930 Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].

Go back
703.0, 358.0
28.0, 28.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016852 MO000000085

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m1785*m77*0.1

nodelay

--

true

0

false

PMID: 18385944, 10547366, 15561106, 11149930 Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].

Go back
759.0, 464.0
24.0, 24.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000085 MO000016872

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c109 : 1
stoichiometry:c108 : 1

m77*m1795*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
946.0, 558.0
27.0, 27.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000144 MO000016872

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m128*m1795*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
334.0, 750.0
27.0, 27.0

p4

p4

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e14

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m14*0.1

nodelay

--

true

0

false

PMID: 18385944 Syk binds to phosphorylated tyrosine residues of ITAM-containing adaptors and is phosphorylated and activated by SFKs.

Go back
781.0, 718.0
25.0, 25.0

p40

p40

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000036287 e68

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m14714*m69*0.1

nodelay

--

true

0

false

PMID: 18385944, 15561106 The Rho inhibitor p190RhoGAP associates with Pyk2 in murine macrophages and is a substrate of Hck and Fgr [36].

Go back
471.0, 407.0
25.0, 25.0

p41

p41

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000044 MO000000136

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c121 : 1
stoichiometry:c118 : 1

m74*m122*0.1

nodelay

--

true

0

false

--

Go back
470.0, 466.0
27.0, 27.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000044 MO000008301

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c122 : 1
stoichiometry:c120 : 1

m74*m1066*0.1

nodelay

--

true

0

false

--

Go back
811.0, 395.0
25.0, 25.0

p43

p43

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e68

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c124 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 18385944, 10547366, 15561106, 11149930 Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].

Go back
878.0, 250.0
27.0, 27.0

p44

p44

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016852 MO000006538

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c127 : 1
stoichiometry:c126 : 1

m1785*m751*0.1

nodelay

--

true

0

false

PMID: 18385944, 10547366, 15561106, 11149930 Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].

Go back
647.0, 463.0
25.0, 25.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e70

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c129 : 1

m71*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
647.0, 559.0
26.0, 26.0

p46

p46

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e71

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
781.0, 778.0
25.0, 25.0

p47

p47

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000036287 MO000089777

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c200 : 1
stoichiometry:c133 : 1

m14714*m63359*0.1

nodelay

--

true

0

false

PMID: 18385944, 15561106 The Rho inhibitor p190RhoGAP associates with Pyk2 in murine macrophages and is a substrate of Hck and Fgr [36].

Go back
779.0, 851.0
25.0, 25.0

p48

p48

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000006538 MO000036287

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m751*m14714*0.1

nodelay

--

true

0

false

PMID: 18385944, 15561106 The Rho inhibitor p190RhoGAP associates with Pyk2 in murine macrophages and is a substrate of Hck and Fgr [36].

Go back
535.0, 347.0
25.0, 25.0

p49

p49

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytosol

--

MO000019718 MO000000044

MO000019719

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c139 : 1
stoichiometry:c138 : 1

m4251*m74*0.1

nodelay

--

true

0

false

PMID: 18385944, 12094222 Vav proteins act as guanine nucleotide exchange factors (GEFs) for Rac and Cdc42 [122].

Go back
347.0, 855.0
27.0, 27.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000000136

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c12 : 1
stoichiometry:c11 : 1
stoichiometry:c13 : 1

m5*m122*0.1

nodelay

--

true

0

false

PMID: 18385944, 17420256, 15519852 Other receptors, such as trimeric G protein-coupled receptors for chemoattractants [14 ? 17] and c-Fms [18, 19] seem to implicate only SFKs, but not Syk. PMID: 18385944 As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.

Go back
578.0, 346.0
27.0, 27.0

p50

p50

cso30:i:ME_GDP-GTPExchange

cso30:i:CC_Cytosol

--

MO000000044 e81

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m74*m85*0.1

nodelay

--

true

0

false

PMID: 18385944, 12094222 Vav proteins act as guanine nucleotide exchange factors (GEFs) for Rac and Cdc42 [122].

Go back
779.0, 892.0
27.0, 27.0

p51

p51

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017852 MO000006538

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c147 : 1
stoichiometry:c144 : 1

m2602*m751*0.1

nodelay

--

true

0

false

PMID: 18385944, 8805332, 12235133 WASp is a substrate of Hck and Fgr and tyrosine phosphorylated WASp exhibits an enhanced capability to trigger actin polymerization in macrophages [124, 125].

Go back
779.0, 940.0
27.0, 27.0

p52

p52

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017852 MO000089777

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c148 : 1
stoichiometry:c146 : 1

m2602*m63359*0.1

nodelay

--

true

0

false

PMID: 18385944, 8805332, 12235133 WASp is a substrate of Hck and Fgr and tyrosine phosphorylated WASp exhibits an enhanced capability to trigger actin polymerization in macrophages [124, 125].

Go back
719.0, 996.0
27.0, 27.0

p53

p53

cso30:i:ME_Polymerization

cso30:i:CC_Cytosol

--

MO000016998 e82

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c151 : 1
stoichiometry:c150 : 1

m1900*m83*0.1

nodelay

--

true

0

false

PMID: 18385944, 8805332, 12235133 WASp is a substrate of Hck and Fgr and tyrosine phosphorylated WASp exhibits an enhanced capability to trigger actin polymerization in macrophages [124, 125].

Go back
410.0, 270.0
27.0, 27.0

p54

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000017529 MO000000136

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c154 : 1
stoichiometry:c153 : 1

m2323*m122*0.1

nodelay

--

true

0

false

PMID: 18385944, 10547366, 10657655 Paxillin, a cytoskeletal adaptor protein recruiting actin-binding and signalling proteins to integrin-based adhesion sites [126], is a substrate of SFKs in macrophages [32, 127, 128].

Go back
101.0, 745.0
30.0, 30.0

p55

p55

cso30:i:CE_CellMigration

cso30:i:CC_Extracellular

--

e103

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1

m106*0.1

nodelay

--

true

0

false

PMID: 18385944, 11149930, 16313344 Notably, SFKs, Pyk2 and c-Cbl also form a molecular complex regulating osteoclast adhesion and migration [41, 42].

Go back
919.0, 1061.0
25.0, 25.0

p56

p56

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016872 MO000008301

e85

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m1795*m1066*0.1

nodelay

--

true

0

false

PMID: 18385944, 11283727 Although Syk binding to phosphorylated ITAM tyrosine residues of adaptor molecules is essential for full Syk activation and downstream signaling (reviewed in [12]), Syk interacts with SFKs, integrins and c-Cbl in leukocytes.

Go back
561.0, 245.0
29.0, 29.0

p57

p57

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

e17

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18385944, 17339487 The findings summarized above also suggest that implication of SFKs in trimeric G protein-coupled receptors signaling (Figure 1) has not relevance in the context of chemotactic migration, but other neutrophil responses to chemoattractants, such as degranulation [14, 16, 59, 64, 65] and ROIs generation [60].

Go back
184.0, 377.0
21.0, 21.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000012555 e87

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c161 : 1
stoichiometry:c162 : 1
stoichiometry:c163 : 1

m1347*m90*0.1

nodelay

--

true

0

false

PMID: 18385944 An early step in neutrophil-endothelium interaction is the binding of PSGL-1 with its endothelial counterreceptors P- and E-selectin.

Go back
194.0, 1030.0
23.0, 23.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066771 e89 e88

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1

m41628*m92*m91*0.1

nodelay

--

true

0

false

PMID: 18385944 Besides mediating leukocyte rolling, PSGL-1 triggers intracellular signals regulating interaction of b2 integrins with ICAM-1; his interaction mediates ¡Èslow rolling¡É and primes leukocytes for arrest on the endothelial surface.

Go back
317.0, 495.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000000136

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m16*m122*0.1

nodelay

--

true

0

false

PMID: 18385944, 9916742, 10527858, 10973280 Other receptors, such as trimeric G protein-coupled receptors for chemoattractants [14 ? 17] and c-Fms [18, 19] seem to implicate only SFKs, but not Syk.

Go back
178.0, 555.0
25.0, 25.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e91 MO000000314 e24

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c171 : 1
stoichiometry:c170 : 1

m94*m249*m24*0.1

nodelay

--

true

0

false

PMID: 18385944 Tyrosine phosphorylated Naf1 recruits the p85-p110delta isoform of PI3-kinase and this results in ¡Èinside-out¡É signals which are essential for full activation of the LFA-1 binding capacity by trimericGprotein-coupled chemoattractant receptors.

Go back
730.0, 1266.0
25.0, 25.0

p61

p61

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e24

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c172 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18385944 Altogether, these findings suggest that SFKs and Syk are implicated in selectin-mediated priming of neutrophil adhesion, recruitment and, potentially, in transcription of pro-inflammatory mediators.

Go back
519.0, 1335.0
25.0, 25.0

p62

p62

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000000136

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m122*0.1

nodelay

--

true

0

false

PMID: 18385944, 17339487, 8666673 It is important to note that SFKs regulate important neutrophil effector functions including superoxide anion generation (see [60, 77] and references contained therein) and degranulation.

Go back
608.0, 1108.0
27.0, 27.0

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e86

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c176 : 1

m89*0.1

nodelay

--

true

0

false

PMID: 18385944, 11937554, 12947983 Release of reactive oxygen intermediates or granule constituents may regulate expression of counterreceptors for leukocyte integrins by the vascular endothelium or tightness of the endothelial cell layer [86, 87].

Go back
1007.0, 1287.0
25.0, 25.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016997 MO000019632

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m1899*m4169*0.1

nodelay

--

true

0

false

PMID: 18385944, 15186216, 10547366, 15561106 Cortactin, an F-actin binding protein interacting with the Arp3 subunit of the Arp2/3 complex and regulating its actin-nucleating activity [129], is a substrate of Hck and Fgr in murine macrophages and Fgr-transfected cell lines [32, 36].

Go back
1007.0, 1255.0
25.0, 25.0

p65

p65

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016997 MO000089777

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c186 : 1
stoichiometry:c182 : 1

m1899*m63359*0.1

nodelay

--

true

0

false

PMID: 18385944, 15186216, 10547366, 15561106 Cortactin, an F-actin binding protein interacting with the Arp3 subunit of the Arp2/3 complex and regulating its actin-nucleating activity [129], is a substrate of Hck and Fgr in murine macrophages and Fgr-transfected cell lines [32, 36].

Go back
1007.0, 1207.0
25.0, 25.0

p66

p66

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016997 MO000006538

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c185 : 1
stoichiometry:c184 : 1

m1899*m751*0.1

nodelay

--

true

0

false

PMID: 18385944, 15186216, 10547366, 15561106 Cortactin, an F-actin binding protein interacting with the Arp3 subunit of the Arp2/3 complex and regulating its actin-nucleating activity [129], is a substrate of Hck and Fgr in murine macrophages and Fgr-transfected cell lines [32, 36].

Go back
887.0, 607.0
25.0, 25.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016872 MO000000143

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m1795*m127*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
795.0, 479.0
25.0, 25.0

p68

p68

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016852 MO000016872

e98

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c190 : 1
stoichiometry:c191 : 1
stoichiometry:c192 : 1

m1785*m1795*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
648.0, 512.0
23.0, 23.0

p69

p69

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c193 : 1
stoichiometry:c194 : 1

m101*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
347.0, 910.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1
stoichiometry:c19 : 1

m13*m18*0.1

nodelay

--

true

0

false

PMID: 18385944, 17420256 SFKs bind to c-Fms in myeloid leukocytes and recruit a c-Cbl/PI3-kinase complex to the membrane.

Go back
646.0, 606.0
27.0, 27.0

p70

p70

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e97

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c195 : 1

m100*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507, 12652654, 11149930 c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].

Go back
511.0, 599.0
25.0, 25.0

p71

p71

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000136 MO000016872

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c198 : 1
stoichiometry:c155 : 1

m122*m1795*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507 Notably, SFKs regulated not only c-Cbl tyrosine phosphorylation but also its capability to bind and redistribute a phosphatidylinositol 3-kinase (PI-3 kinase) activity to a detergent insoluble fraction [31].

Go back
571.0, 794.0
25.0, 25.0

p72

p72

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000036287 e103

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c202 : 1
stoichiometry:c206 : 1
stoichiometry:c203 : 1

m14714*m106*0.1

nodelay

--

true

0

false

PMID: 18385944, 15561106 In macrophages, the Rho inhibitor p190RhoGAP interacts with this complex via direct or indirect binding to Pyk2 [36].

Go back
571.0, 655.0
25.0, 25.0

p73

p73

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e101

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c199 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507 Notably, SFKs regulated not only c-Cbl tyrosine phosphorylation but also its capability to bind and redistribute a phosphatidylinositol 3-kinase (PI-3 kinase) activity to a detergent insoluble fraction [31].

Go back
571.0, 747.0
25.0, 25.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e102 MO000016852

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c205 : 1
stoichiometry:c204 : 1

m105*m1785*0.1

nodelay

--

true

0

false

PMID: 18385944, 9687507 Notably, SFKs regulated not only c-Cbl tyrosine phosphorylation but also its capability to bind and redistribute a phosphatidylinositol 3-kinase (PI-3 kinase) activity to a detergent insoluble fraction [31]. PMID: 18385944, 11149930, 16313344 Notably, SFKs, Pyk2 and c-Cbl also form a molecular complex regulating osteoclast adhesion and migration [41, 42].

Go back
976.0, 136.0
24.0, 24.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000006538 e105

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c209 : 1
stoichiometry:c208 : 1
stoichiometry:c210 : 1

m751*m108*0.1

nodelay

--

true

0

false

PMID: 18385944 As far as myeloid cells are concerned, Src was reported to bind to the b3 integrin in osteoclasts constitutively [11] and we found that Fgr and Hck associated with b1 in BMDM (unpublished observation).

Go back
921.0, 129.0
25.0, 25.0

p76

p76

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000089777 e105

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c211 : 1
stoichiometry:c212 : 1
stoichiometry:c213 : 1

m63359*m108*0.1

nodelay

--

true

0

false

PMID: 18385944 As far as myeloid cells are concerned, Src was reported to bind to the b3 integrin in osteoclasts constitutively [11] and we found that Fgr and Hck associated with b1 in BMDM (unpublished observation).

Go back
180.0, 343.0
25.0, 25.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e107 MO000012555

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c215 : 1
stoichiometry:c216 : 1

m110*m1347*0.1

nodelay

--

true

0

false

PMID: 18385944 An early step in neutrophil-endothelium interaction is the binding of PSGL-1 with its endothelial counterreceptors P- and E-selectin.

Go back
963.0, 1063.0
25.0, 25.0

p78

p78

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016872 MO000019573

e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c217 : 1
stoichiometry:c218 : 1
stoichiometry:c219 : 1

m1795*m4118*0.1

nodelay

--

true

0

false

--

Go back
314.0, 206.0
27.0, 27.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000000136

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c21 : 1
stoichiometry:c22 : 1

m21*m122*0.1

nodelay

--

true

0

false

PMID: 18395944, 17632516 PSGL-1, the major leukocyte ligand for endothelial selectins, implicates SFKs for phosphorylation of its associated molecule Naf1 which in turn binds PI3-kinase.

Go back
335.0, 175.0
25.0, 25.0

p9

p9

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 18395944, 17632516 PSGL-1, the major leukocyte ligand for endothelial selectins, implicates SFKs for phosphorylation of its associated molecule Naf1 which in turn binds PI3-kinase.

Go back
280.0, 616.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.50986776965385, 774.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.0, 127.94635316997733

c100

c100

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 300.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.9932582089723, 307.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
912.0, 300.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.2663112244052, 311.0

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.0, 320.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.0, 386.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 320.0

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 476.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
771.0273855985976, 495.99995312667454

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
381.99432038939614, 407.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0002771031583, 639.9999999952008

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
971.8646187432906, 529.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.0, 592.9999996975646

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 572.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
752.0, 731.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 375.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
740.4262408218646, 743.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
503.9924492668405, 420.3474977942105

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.0, 432.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
501.1214751973158, 436.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.0, 867.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.0, 480.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
427.0, 397.0

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
407.0, 489.15135438863337

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
804.0, 375.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 408.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 273.15135438863337

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 238.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
911.6248757770875, 211.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
680.0, 476.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.0, 476.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
299.6564023547028, 878.0

c13

c13

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.0, 572.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.0, 572.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.0, 745.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
753.1354932516747, 803.0

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
811.9846228190856, 179.64903051961335

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.0, 745.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
761.974522228289, 861.6379617782632

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
506.0, 360.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.4591289780632, 336.7201327147385

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
537.0, 379.7873373466686

c139

c139

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
273.0, 508.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
548.0, 378.7432031476084

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
613.0, 360.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 332.635762733503

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 906.0

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
755.2469504755443, 917.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.0, 917.0

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
758.0, 954.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
813.8575911524703, 199.7167765262268

c147

c147

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
813.9968862786707, 304.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
754.0, 1010.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
343.5575641729525, 407.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
746.0, 1020.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
733.0, 966.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
434.3332376839457, 246.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
437.0, 247.67077713795675

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.0, 304.9459069717681

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 624.0

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.0068492214873, 875.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
407.0, 511.5909383484784

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
932.0, 1086.0

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.0, 274.3680270710665

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
278.02899607658037, 479.8201065633589

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.0, 260.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
212.9992696398396, 387.0

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
152.0, 388.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.0, 393.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
225.0, 1042.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.5307152332491, 1019.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.0, 1048.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
67.99702548202404, 424.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
145.0, 568.0

c168

c168

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
210.8294223295591, 572.6432120938581

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
293.0, 923.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 556.8121079572823

c170

c170

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
92.03044494054166, 107.90212195157926

c171

c171

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
710.9945186701341, 1279.0

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
43.61438106791081, 392.0

c174

c174

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 1315.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.0, 1135.0

c176

c176

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
622.2862128340927, 270.0

c177

c177

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
979.0, 1276.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.0, 1300.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
379.9822812628529, 920.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.5424513544061, 1309.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.0, 1268.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0899458438937, 1239.1877316447983

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
979.0, 1236.3281261544707

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.0, 1220.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1002.0, 203.0

c185

c185

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1006.0, 303.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
900.0021070389017, 439.8100193038606

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.0, 620.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
681.0, 620.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.92024951409445, 930.0

c19

c19

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
808.0, 314.0

c190

c190

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
807.8351089542575, 511.99999908124374

c191

c191

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
735.5665770913955, 497.0

c192

c192

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
679.0, 524.0

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
625.0, 524.0

c194

c194

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
617.0, 620.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
419.0, 407.0

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 668.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.88915650528, 623.0668811939566

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.4698886744255, 677.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
357.0514775921964, 407.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
283.0, 202.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
813.9757594979319, 306.0

c200

c200

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.0, 723.0

c201

c201

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.1666680166409, 738.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
584.0, 819.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
546.0, 760.0

c204

c204

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.418034702384, 299.9521041085053

c205

c205

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 771.0

c206

c206

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.0, 760.0

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1007.5693118796269, 105.0

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 167.99306458473882

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.99986890095704, 220.0457992085106

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 148.0

c210

c210

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
940.8027182388947, 161.492981414188

c211

c211

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
953.8224193126193, 103.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.0, 113.65685424949238

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
153.0, 356.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
212.66829085023244, 362.2797621446637

c215

c215

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
205.0, 353.37169119481973

c216

c216

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
946.0, 875.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.5727049087313, 1088.5606523856504

c218

c218

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
976.0, 1088.0

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
291.82486619897395, 171.3812746502559

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
290.18458696386074, 262.0745328934242

c220

c220

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
287.0, 153.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 159.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
365.0, 147.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
396.0, 144.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
415.80185216471324, 188.7694922435432

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
27.659150385916064, 59.58248939089742

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
284.0, 300.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
295.01262840623673, 623.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
424.0, 199.99999322316447

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
808.0, 131.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
815.0, 125.91023120718746

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
380.9982392690249, 407.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.99959043380517, 406.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 1079.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
301.90550082503523, 1087.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.0, 1269.0

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
288.0, 660.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.09773440987675, 1276.0

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
295.0, 1127.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.8485155621994, 1135.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
291.0, 1309.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
303.72456828074905, 1317.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
378.9998168859063, 523.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
294.0, 1176.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.01262840623673, 1183.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.99988334045315, 521.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
297.0, 1356.177733898281

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.50986776965385, 670.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
301.6127939807138, 1365.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1061.9949028347803, 197.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1002.0, 200.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1054.0, 207.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1058.9952479948288, 297.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 300.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 307.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.0, 218.1165361451483

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.0, 217.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
947.6378679090274, 203.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 712.0

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
992.0, 315.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.6746825652904, 407.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1058.9943100988535, 449.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
984.0, 452.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1002.0, 470.4404466988269

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 460.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1092.0, 576.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1099.0, 624.0

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1173.0, 624.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1142.0, 699.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
363.30733935933034, 535.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.0, 699.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1152.0455126623185, 711.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.0, 529.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1075.0, 751.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.0, 761.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 212.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1146.0, 807.0

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1067.6336570575136, 770.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
931.702507162378, 451.54869619715305

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1006.0, 872.7705920107007

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.8262546692157, 721.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
959.0, 859.097553721736

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1066.0, 859.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.0, 859.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.1148943220342, 455.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1078.0, 955.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1070.0, 964.0

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
535.0, 213.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.0, 1011.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1071.0, 1021.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1075.0, 1063.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 764.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1067.0, 1073.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1232.9992471274784, 635.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1138.0, 911.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1149.0518397602302, 919.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.0, 1116.2460374062957

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
502.0, 16.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
498.0, 35.79428260231235

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 29.0

c97

c97

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 180.55669626192162

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 134.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back