_enti_e7
_enti_e8
_enti_e1
_enti_e9
_enti_e10
_enti_e2
_enti_e3
_enti_e4
_enti_e55
_enti_e53
_enti_e59
_enti_e51
_enti_e54
_enti_e52
_enti_e56
_enti_e50
_enti_e58
_enti_e61
_enti_e57
_enti_e62
_enti_e60
g2_fact_g2
g2_fact_g12
g2_fact_g13
g1_fact_g14
g1_fact_g1
p1_propro_p1
PMID: 18385944, 8132624, 8327512, 9581795
Because SFKs have been reported to associate with Fcg receptors [135138], this association may represent the mechanism dictating proximity between SFKs and ITAM-containing adaptors.
c1 cso30:c:InputProcess connector
c2 cso30:c:InputProcess connector
c3 cso30:c:OutputProcess connector
p2_propro_p2
PMID: 18385944
Syk binds to phosphorylated tyrosine residues of ITAM-containing adaptors and is phosphorylated and activated by SFKs.
c4 cso30:c:InputProcess connector
c5 cso30:c:OutputProcess connector
p3_propro_p3
PMID: 18385944
Syk binds to phosphorylated tyrosine residues of ITAM-containing adaptors and is phosphorylated and activated by SFKs.
c6 cso30:c:InputProcess connector
c7 cso30:c:InputProcess connector
c8 cso30:c:OutputProcess connector
p4_propro_p4
PMID: 18385944
Syk binds to phosphorylated tyrosine residues of ITAM-containing adaptors and is phosphorylated and activated by SFKs.
c9 cso30:c:InputProcess connector
c10 cso30:c:OutputProcess connector
p5_propro_p5
PMID: 18385944, 17420256, 15519852
Other receptors, such as trimeric G protein-coupled receptors for chemoattractants [14 17] and c-Fms [18, 19] seem to implicate only SFKs, but not Syk.
PMID: 18385944
As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.
c12 cso30:c:InputProcess connector
c11 cso30:c:InputProcess connector
c13 cso30:c:OutputProcess connector
p6_propro_p6
PMID: 18385944, 9916742, 10527858, 10973280
Other receptors, such as trimeric G protein-coupled receptors for chemoattractants [14 17] and c-Fms [18, 19] seem to implicate only SFKs, but not Syk.
c14 cso30:c:InputProcess connector
c15 cso30:c:InputProcess connector
c16 cso30:c:OutputProcess connector
p7_propro_p7
PMID: 18385944, 17420256
SFKs bind to c-Fms in myeloid leukocytes and recruit a c-Cbl/PI3-kinase complex to the membrane.
c17 cso30:c:InputProcess connector
c18 cso30:c:InputProcess connector
c19 cso30:c:OutputProcess connector
p8_propro_p8
PMID: 18395944, 17632516
PSGL-1, the major leukocyte ligand for endothelial selectins, implicates SFKs for phosphorylation of its associated molecule Naf1 which in turn binds PI3-kinase.
c20 cso30:c:InputProcess connector
c21 cso30:c:InputProcess connector
c22 cso30:c:OutputProcess connector
p9_propro_p9
PMID: 18395944, 17632516
PSGL-1, the major leukocyte ligand for endothelial selectins, implicates SFKs for phosphorylation of its associated molecule Naf1 which in turn binds PI3-kinase.
c23 cso30:c:InputProcess connector
c24 cso30:c:OutputProcess connector
p10_propro_p10
PMID: 18395944, 17632516
PSGL-1, the major leukocyte ligand for endothelial selectins, implicates SFKs for phosphorylation of its associated molecule Naf1 which in turn binds PI3-kinase.
c25 cso30:c:InputProcess connector
c27 cso30:c:InputProcess connector
c26 cso30:c:OutputProcess connector
p12_propro_p12
PMID: 18385944, 12387735
PSGL-1 also triggers phosphorylation of ezrin and moesin, two ITAM-containing molecules associated with its cytoplasmic tail [20]; it is conceivable that ezrin and moesin phosphorylation is mediated by SFKs.
c29 cso30:c:InputProcess connector
c220 cso30:c:OutputProcess connector
p13_propro_p13
PMID: 18385944
Receptors for chemokines bind SFKs in phagocytes likely via binding to beta-arrestin.
PMID: 18385944
As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.
c32 cso30:c:InputProcess connector
c33 cso30:c:InputProcess connector
c34 cso30:c:OutputProcess connector
p14_propro_p14
PMID: 18385944
In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain.
PMID: 18385944
As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.
c35 cso30:c:InputProcess connector
c37 cso30:c:InputProcess connector
c38 cso30:c:OutputProcess connector
p15_propro_p15
PMID: 18385944
In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain.
PMID: 18385944
As indicated, interaction of SFK with integrins, c-Cbl and b-arrestin have been reported to occur via the SH3 domain.
c36 cso30:c:InputProcess connector
c39 cso30:c:InputProcess connector
c40 cso30:c:OutputProcess connector
p16_propro_p16
c41 cso30:c:InputProcess connector
c42 cso30:c:OutputProcess connector
p17_propro_p17
c43 cso30:c:InputProcess connector
c44 cso30:c:OutputProcess connector
p18_propro_p18
PMID: 18385944
In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain.
c45 cso30:c:InputProcess connector
c46 cso30:c:InputProcess connector
c47 cso30:c:OutputProcess connector
p19_propro_p19
PMID: 18385944
In the case of integrins, both SFKs and Syk have been reported to bind to the integrin beta3 or beta2 chain.
c48 cso30:c:InputProcess connector
c49 cso30:c:InputProcess connector
c50 cso30:c:OutputProcess connector
p20_propro_p20
PMID: 18385944, 10527858, 10973280, 7535337
Receptors for chemokines (CCR3, CXCR1) directly [15] or indirectly [16] interacts with Fgr and Hck in granulocytes and the urokinase plasminogen-activator-receptor, a powerful chemoattractant, forms a membrane signaling complex containing the Srcfamily kinases, Fgr, Fyn, Lyn and Hck, as well as b2 integrins, in monocytes [6].
c51 cso30:c:InputProcess connector
c52 cso30:c:InputProcess connector
c57 cso30:c:InputProcess connector
c53 cso30:c:OutputProcess connector
p21_propro_p21
PMID: 18385944, 10527858, 10973280, 7535337
Receptors for chemokines (CCR3, CXCR1) directly [15] or indirectly [16] interacts with Fgr and Hck in granulocytes and the urokinase plasminogen-activator-receptor, a powerful chemoattractant, forms a membrane signaling complex containing the Srcfamily kinases, Fgr, Fyn, Lyn and Hck, as well as b2 integrins, in monocytes [6].
c54 cso30:c:InputProcess connector
c55 cso30:c:InputProcess connector
c58 cso30:c:InputProcess connector
c56 cso30:c:OutputProcess connector
p22_propro_p22
PMID: 18385944, 10527858, 10973280, 7535337
Receptors for chemokines (CCR3, CXCR1) directly [15] or indirectly [16] interacts with Fgr and Hck in granulocytes and the urokinase plasminogen-activator-receptor, a powerful chemoattractant, forms a membrane signaling complex containing the Srcfamily kinases, Fgr, Fyn, Lyn and Hck, as well as b2 integrins, in monocytes [6].
PMID: 18385944, 7535337
The first strong evidence suggesting a link between a chemoattractant receptor, b2 integrins and SFKs in regulating mononuclear phagocyte migration derives from studies showing that the urokinase type plasminogen activator-receptor (uPA-R), the b2 integrins LFA-1 and CR3, and the SFK members Hck, Fgr, Lyn nd Fyn form a large molecular complex in human monocytes [6].
c59 cso30:c:InputProcess connector
c60 cso30:c:InputProcess connector
c62 cso30:c:InputProcess connector
c63 cso30:c:InputProcess connector
c64 cso30:c:InputProcess connector
c61 cso30:c:InputProcess connector
c65 cso30:c:OutputProcess connector
p23_propro_p23
PMID: 18385944, 8810279, 7650013
Neutrophil stimulation with chemoattractants activates a Lyn/Shc/p85-p110 phosphatidylinositol 3-kinase pathway (PI-3K) [93, 94].
c66 cso30:c:InputProcess connector
c68 cso30:c:InputAssociation connector
c67 cso30:c:OutputProcess connector
p24_propro_p24
PMID: 18385944, 12208881
Interaction of the chemokine Stromal cell-derived factor (SDF/CXCL12) with its receptor (CXCR4) triggers a signalling pathway implicatingLyn and PI-3K in HL-60 cells and hematopoietic progenitors and SDF-induced cell migration is defective in Lyndeficient bone marrow cells [99].
c69 cso30:c:InputProcess connector
c70 cso30:c:InputProcess connector
c71 cso30:c:OutputProcess connector
p25_propro_p25
PMID: 18385944, 12208881
Interaction of the chemokine Stromal cell-derived factor (SDF/CXCL12) with its receptor (CXCR4) triggers a signalling pathway implicatingLyn and PI-3K in HL-60 cells and hematopoietic progenitors and SDF-induced cell migration is defective in Lyndeficient bone marrow cells [99].
c72 cso30:c:InputProcess connector
c73 cso30:c:InputProcess connector
c75 cso30:c:InputProcess connector
c74 cso30:c:OutputProcess connector
p26_propro_p26
PMID: 18385944, 12208881
Interaction of the chemokine Stromal cell-derived factor (SDF/CXCL12) with its receptor (CXCR4) triggers a signalling pathway implicatingLyn and PI-3K in HL-60 cells and hematopoietic progenitors and SDF-induced cell migration is defective in Lyndeficient bone marrow cells [99].
c76 cso30:c:InputAssociation connector
p27_propro_p27
PMID: 18385944, 11157475
SDF/CXCL12-induced cell migration in CXCR4 expressing pre-B lymphoma cells involves formation of complexes between CXCR4, the tyrosine phosphatase SHP2, Cbl and Fyn [102].
c77 cso30:c:InputProcess connector
c78 cso30:c:InputProcess connector
c79 cso30:c:InputProcess connector
c80 cso30:c:InputProcess connector
c81 cso30:c:OutputProcess connector
p28_propro_p28
PMID: 18385944, 11157475
SDF/CXCL12-induced cell migration in CXCR4 expressing pre-B lymphoma cells involves formation of complexes between CXCR4, the tyrosine phosphatase SHP2, Cbl and Fyn [102].
c82 cso30:c:InputAssociation connector
p29_propro_p29
PMID: 18385944, 15955842
Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].
c83 cso30:c:InputProcess connector
c84 cso30:c:InputProcess connector
c85 cso30:c:OutputProcess connector
p30_propro_p30
PMID: 18385944, 15955842
Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].
c86 cso30:c:InputProcess connector
c87 cso30:c:InputProcess connector
c88 cso30:c:OutputProcess connector
p31_propro_p31
PMID: 18385944, 15955842
Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].
c89 cso30:c:InputProcess connector
c90 cso30:c:OutputProcess connector
p32_propro_p32
PMID: 18385944, 15955842
Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].
c91 cso30:c:InputProcess connector
c92 cso30:c:InputProcess connector
c93 cso30:c:OutputProcess connector
p33_propro_p33
PMID: 18385944, 15955842
Chemoattractant receptor engagement in a T cell line induces Fyn-dependent PI-3K activation, and overexpression of a Fyn mutant form inhibits chemoattractant-induced cell migration [105].
c94 cso30:c:InputAssociation connector
p34_propro_p34
PMID: 18385944, 10747947
MIP-1b/CCL4-CCR5 interaction induces formation of a signaling complex which includes Syk [109].
c95 cso30:c:InputProcess connector
c96 cso30:c:InputProcess connector
c97 cso30:c:OutputProcess connector
p35_propro_p35
PMID: 18385944, 10747947
MIP-1b/CCL4-CCR5 interaction induces formation of a signaling complex which includes Syk [109].
c99 cso30:c:InputProcess connector
c98 cso30:c:InputProcess connector
c100 cso30:c:OutputProcess connector
p36_propro_p36
PMID: 18385944, 10547366, 15561106, 11149930
Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].
c101 cso30:c:InputProcess connector
c103 cso30:c:InputProcess connector
c102 cso30:c:OutputProcess connector
p37_propro_p37
PMID: 18385944, 10547366, 15561106, 11149930
Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].
c104 cso30:c:InputProcess connector
c105 cso30:c:InputProcess connector
c106 cso30:c:OutputProcess connector
p38_propro_p38
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c107 cso30:c:InputProcess connector
c109 cso30:c:InputProcess connector
c108 cso30:c:OutputProcess connector
p39_propro_p39
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c111 cso30:c:InputProcess connector
c112 cso30:c:InputProcess connector
c113 cso30:c:OutputProcess connector
p40_propro_p40
PMID: 18385944, 15561106
The Rho inhibitor p190RhoGAP associates with Pyk2 in murine macrophages and is a substrate of Hck and Fgr [36].
c114 cso30:c:InputProcess connector
c115 cso30:c:InputProcess connector
c116 cso30:c:OutputProcess connector
p41_propro_p41
c117 cso30:c:InputProcess connector
c121 cso30:c:InputAssociation connector
c118 cso30:c:OutputProcess connector
p42_propro_p42
c119 cso30:c:InputProcess connector
c122 cso30:c:InputAssociation connector
c120 cso30:c:OutputProcess connector
p43_propro_p43
PMID: 18385944, 10547366, 15561106, 11149930
Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].
c123 cso30:c:InputProcess connector
c124 cso30:c:OutputProcess connector
p44_propro_p44
PMID: 18385944, 10547366, 15561106, 11149930
Pyk2 is a substrate of Hck and Fgr and interacts with Fgr in murine macrophages and Src in osteoclasts [32, 36, 41].
c125 cso30:c:InputProcess connector
c127 cso30:c:InputAssociation connector
c126 cso30:c:OutputProcess connector
p45_propro_p45
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c128 cso30:c:InputProcess connector
c129 cso30:c:OutputProcess connector
p46_propro_p46
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c130 cso30:c:InputProcess connector
c131 cso30:c:OutputProcess connector
p47_propro_p47
PMID: 18385944, 15561106
The Rho inhibitor p190RhoGAP associates with Pyk2 in murine macrophages and is a substrate of Hck and Fgr [36].
c132 cso30:c:InputProcess connector
c200 cso30:c:InputAssociation connector
c133 cso30:c:OutputProcess connector
p48_propro_p48
PMID: 18385944, 15561106
The Rho inhibitor p190RhoGAP associates with Pyk2 in murine macrophages and is a substrate of Hck and Fgr [36].
c134 cso30:c:InputAssociation connector
c135 cso30:c:InputProcess connector
c136 cso30:c:OutputProcess connector
p49_propro_p49
PMID: 18385944, 12094222
Vav proteins act as guanine nucleotide exchange factors (GEFs) for Rac and Cdc42 [122].
c137 cso30:c:InputProcess connector
c139 cso30:c:InputAssociation connector
c138 cso30:c:OutputProcess connector
p50_propro_p50
PMID: 18385944, 12094222
Vav proteins act as guanine nucleotide exchange factors (GEFs) for Rac and Cdc42 [122].
c140 cso30:c:InputAssociation connector
c141 cso30:c:InputProcess connector
c142 cso30:c:OutputProcess connector
p51_propro_p51
PMID: 18385944, 8805332, 12235133
WASp is a substrate of Hck and Fgr and tyrosine phosphorylated WASp exhibits an enhanced capability to trigger actin polymerization in macrophages [124, 125].
c143 cso30:c:InputProcess connector
c147 cso30:c:InputAssociation connector
c144 cso30:c:OutputProcess connector
p52_propro_p52
PMID: 18385944, 8805332, 12235133
WASp is a substrate of Hck and Fgr and tyrosine phosphorylated WASp exhibits an enhanced capability to trigger actin polymerization in macrophages [124, 125].
c145 cso30:c:InputProcess connector
c148 cso30:c:InputAssociation connector
c146 cso30:c:OutputProcess connector
p53_propro_p53
PMID: 18385944, 8805332, 12235133
WASp is a substrate of Hck and Fgr and tyrosine phosphorylated WASp exhibits an enhanced capability to trigger actin polymerization in macrophages [124, 125].
c149 cso30:c:InputProcess connector
c151 cso30:c:InputAssociation connector
c150 cso30:c:OutputProcess connector
p54_propro_p54
PMID: 18385944, 10547366, 10657655
Paxillin, a cytoskeletal adaptor protein recruiting actin-binding and signalling proteins to integrin-based adhesion sites [126], is a substrate of SFKs in macrophages [32, 127, 128].
c152 cso30:c:InputProcess connector
c154 cso30:c:InputAssociation connector
c153 cso30:c:OutputProcess connector
p55_propro_p55
PMID: 18385944, 11149930, 16313344
Notably, SFKs, Pyk2 and c-Cbl also form a molecular complex regulating osteoclast adhesion and migration [41, 42].
c207 cso30:c:InputAssociation connector
p56_propro_p56
PMID: 18385944, 11283727
Although Syk binding to phosphorylated ITAM tyrosine residues of adaptor molecules is essential for full Syk activation and downstream signaling (reviewed in [12]), Syk interacts with SFKs, integrins and c-Cbl in leukocytes.
c156 cso30:c:InputProcess connector
c157 cso30:c:InputProcess connector
c158 cso30:c:OutputProcess connector
p57_propro_p57
PMID: 18385944, 17339487
The findings summarized above also suggest that implication of SFKs in trimeric G protein-coupled receptors signaling (Figure 1) has not relevance in the context of chemotactic migration, but other neutrophil responses to chemoattractants, such as degranulation [14, 16, 59, 64, 65] and ROIs generation [60].
c159 cso30:c:InputAssociation connector
c160 cso30:c:OutputProcess connector
p58_propro_p58
PMID: 18385944
An early step in neutrophil-endothelium interaction is the binding of PSGL-1 with its endothelial counterreceptors P- and E-selectin.
c161 cso30:c:InputProcess connector
c162 cso30:c:InputProcess connector
c163 cso30:c:OutputProcess connector
p59_propro_p59
PMID: 18385944
Besides mediating leukocyte rolling, PSGL-1 triggers intracellular signals regulating interaction of b2 integrins with ICAM-1; his interaction mediates “slow rolling” and primes leukocytes for arrest on the endothelial surface.
c164 cso30:c:InputProcess connector
c165 cso30:c:InputProcess connector
c167 cso30:c:InputAssociation connector
c166 cso30:c:OutputProcess connector
p60_propro_p60
PMID: 18385944
Tyrosine phosphorylated Naf1 recruits the p85-p110delta isoform of PI3-kinase and this results in “inside-out” signals which are essential for full activation of the LFA-1 binding capacity by trimericGprotein-coupled chemoattractant receptors.
c168 cso30:c:InputProcess connector
c169 cso30:c:InputProcess connector
c171 cso30:c:InputAssociation connector
c170 cso30:c:OutputProcess connector
p61_propro_p61
PMID: 18385944
Altogether, these findings suggest that SFKs and Syk are implicated in selectin-mediated priming of neutrophil adhesion, recruitment and, potentially, in transcription of pro-inflammatory mediators.
c28 cso30:c:InputAssociation connector
c172 cso30:c:OutputProcess connector
p62_propro_p62
PMID: 18385944, 17339487, 8666673
It is important to note that SFKs regulate important neutrophil effector functions including superoxide anion generation (see [60, 77] and references contained therein) and degranulation.
c174 cso30:c:InputAssociation connector
c175 cso30:c:OutputProcess connector
p63_propro_p63
PMID: 18385944, 11937554, 12947983
Release of reactive oxygen intermediates or granule constituents may regulate expression of counterreceptors for leukocyte integrins by the vascular endothelium or tightness of the endothelial cell layer [86, 87].
c177 cso30:c:InputAssociation connector
c176 cso30:c:OutputProcess connector
p64_propro_p64
PMID: 18385944, 15186216, 10547366, 15561106
Cortactin, an F-actin binding protein interacting with the Arp3 subunit of the Arp2/3 complex and regulating its actin-nucleating activity [129], is a substrate of Hck and Fgr in murine macrophages and Fgr-transfected cell lines [32, 36].
c178 cso30:c:InputProcess connector
c179 cso30:c:InputProcess connector
c180 cso30:c:OutputProcess connector
p65_propro_p65
PMID: 18385944, 15186216, 10547366, 15561106
Cortactin, an F-actin binding protein interacting with the Arp3 subunit of the Arp2/3 complex and regulating its actin-nucleating activity [129], is a substrate of Hck and Fgr in murine macrophages and Fgr-transfected cell lines [32, 36].
c181 cso30:c:InputProcess connector
c186 cso30:c:InputAssociation connector
c182 cso30:c:OutputProcess connector
p66_propro_p66
PMID: 18385944, 15186216, 10547366, 15561106
Cortactin, an F-actin binding protein interacting with the Arp3 subunit of the Arp2/3 complex and regulating its actin-nucleating activity [129], is a substrate of Hck and Fgr in murine macrophages and Fgr-transfected cell lines [32, 36].
c183 cso30:c:InputProcess connector
c185 cso30:c:InputAssociation connector
c184 cso30:c:OutputProcess connector
p68_propro_p68
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c190 cso30:c:InputProcess connector
c191 cso30:c:InputProcess connector
c192 cso30:c:OutputProcess connector
p69_propro_p69
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c193 cso30:c:InputProcess connector
c194 cso30:c:OutputProcess connector
p67_propro_p67
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c110 cso30:c:InputProcess connector
c187 cso30:c:InputProcess connector
c188 cso30:c:OutputProcess connector
p70_propro_p70
PMID: 18385944, 9687507, 12652654, 11149930
c-Cbl is a substrate of SFKs and interacts with Fgr and Lyn in murine macrophages and Src and Pyk2 in osteoclasts [31, 33, 41].
c189 cso30:c:InputProcess connector
c195 cso30:c:OutputProcess connector
p71_propro_p71
PMID: 18385944, 9687507
Notably, SFKs regulated not only c-Cbl tyrosine phosphorylation but also its capability to bind and redistribute a phosphatidylinositol 3-kinase (PI-3 kinase) activity to a detergent insoluble fraction [31].
c196 cso30:c:InputProcess connector
c198 cso30:c:InputProcess connector
c155 cso30:c:OutputProcess connector
p72_propro_p72
PMID: 18385944, 15561106
In macrophages, the Rho inhibitor p190RhoGAP interacts with this complex via direct or indirect binding to Pyk2 [36].
c202 cso30:c:InputProcess connector
c206 cso30:c:InputProcess connector
c203 cso30:c:OutputProcess connector
p73_propro_p73
PMID: 18385944, 9687507
Notably, SFKs regulated not only c-Cbl tyrosine phosphorylation but also its capability to bind and redistribute a phosphatidylinositol 3-kinase (PI-3 kinase) activity to a detergent insoluble fraction [31].
c197 cso30:c:InputProcess connector
c199 cso30:c:OutputProcess connector
p74_propro_p74
PMID: 18385944, 9687507
Notably, SFKs regulated not only c-Cbl tyrosine phosphorylation but also its capability to bind and redistribute a phosphatidylinositol 3-kinase (PI-3 kinase) activity to a detergent insoluble fraction [31].
PMID: 18385944, 11149930, 16313344
Notably, SFKs, Pyk2 and c-Cbl also form a molecular complex regulating osteoclast adhesion and migration [41, 42].
c201 cso30:c:InputProcess connector
c205 cso30:c:InputProcess connector
c204 cso30:c:OutputProcess connector
p75_propro_p75
PMID: 18385944
As far as myeloid cells are concerned, Src was reported to bind to the b3 integrin in osteoclasts constitutively [11] and we found that Fgr and Hck associated with b1 in BMDM (unpublished observation).
c209 cso30:c:InputProcess connector
c208 cso30:c:InputProcess connector
c210 cso30:c:OutputProcess connector
p76_propro_p76
PMID: 18385944
As far as myeloid cells are concerned, Src was reported to bind to the b3 integrin in osteoclasts constitutively [11] and we found that Fgr and Hck associated with b1 in BMDM (unpublished observation).
c211 cso30:c:InputProcess connector
c212 cso30:c:InputProcess connector
c213 cso30:c:OutputProcess connector
p77_propro_p77
PMID: 18385944
An early step in neutrophil-endothelium interaction is the binding of PSGL-1 with its endothelial counterreceptors P- and E-selectin.
c214 cso30:c:InputProcess connector
c215 cso30:c:InputProcess connector
c216 cso30:c:OutputProcess connector
p78_propro_p78
c217 cso30:c:InputProcess connector
c218 cso30:c:InputProcess connector
c219 cso30:c:OutputProcess connector
Syk_enti_MO000008301
Syk
Src family_enti_MO000000136
Src family
ligand: FCgammaR: ITAM containing adaptor_enti_e6
ligand: FCgammaR: ITAM containing adaptor
ligand: FCgammaR: ITAM containing adaptor: Src family_enti_e12
ligand: FCgammaR: ITAM containing adaptor: Src family
ligand: FCgammaR: ITAM containing adaptor{pT}: Src family_enti_e11
ligand: FCgammaR: ITAM containing adaptor{pT}: Src family
ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk_enti_e14
ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk
ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk{p}_enti_e15
ligand: FCgammaR: ITAM containing adaptor{p}: Src family: Syk{p}
ligand: c-Fms_enti_e5
ligand: c-Fms
ligand: c-Fms: Src family_enti_e13
ligand: c-Fms: Src family
ligand: GPCR_enti_e16
ligand: GPCR
ligand: GPCR: Src family_enti_e17
ligand: GPCR: Src family
c-Cbl_enti_MO000016872
c-Cbl
PI3K_enti_MO000000030
PI3K
c-Cbl: PI3K_enti_e18
c-Cbl: PI3K
ligand: c-Fms: Src family: c-Cbl: PI3K_enti_e19
ligand: c-Fms: Src family: c-Cbl: PI3K
PSGL-1: SELE: Naf1_enti_e21
PSGL-1: SELE: Naf1
PSGL-1: SELE: Naf1: Src family_enti_e22
PSGL-1: SELE: Naf1: Src family
PSGL-1: SELE: Naf1{p}: Src family_enti_e23
PSGL-1: SELE: Naf1{p}: Src family
PSGL-1: SELE: Naf1{p}: Src family: PI3K_enti_e24
PSGL-1: SELE: Naf1{p}: Src family: PI3K
chemokine: chemokine receptor: beta-arrestin_enti_e26
chemokine: chemokine receptor: beta-arrestin
chemokine: chemokine receptor: beta-arrestin: Src family_enti_e27
chemokine: chemokine receptor: beta-arrestin: Src family
ligand: beta2-integrin:DAp-12_enti_e28
ligand: beta2-integrin:DAp-12
ligand: beta3-integrin: DAP-12_enti_e29
ligand: beta3-integrin: DAP-12
ligand: beta2-integrin: DAP-12: Src family_enti_e30
ligand: beta2-integrin: DAP-12: Src family
ligand: beta3-integrin: DAP-12: Src family_enti_e31
ligand: beta3-integrin: DAP-12: Src family
ligand: beta2-integrin: DAP-12{p}: Src family_enti_e32
ligand: beta2-integrin: DAP-12{p}: Src family
ligand: beta3-integrin: DAP-12{p}: Src family_enti_e33
ligand: beta3-integrin: DAP-12{p}: Src family
ligand: beta2-integrin: DAP-12{p}: Src family: Syk_enti_e34
ligand: beta2-integrin: DAP-12{p}: Src family: Syk
ligand: beta3-integrin: DAP-12{p}: Src family: Syk_enti_e35
ligand: beta3-integrin: DAP-12{p}: Src family: Syk
FGR_enti_MO000089777
FGR
Hck_enti_MO000006538
Hck
chemokine: CCR3_enti_e36
chemokine: CCR3
chemokine: CXCR1_enti_e37
chemokine: CXCR1
chemokine: CCR3: Hck: FGR_enti_e38
chemokine: CCR3: Hck: FGR
chemokine: CXCR1: Hck: FGR_enti_e39
chemokine: CXCR1: Hck: FGR
chemoattrcatant: uPAR_enti_e40
chemoattrcatant: uPAR
Fyn_enti_MO000000143
Fyn
chemoattrcatant: uPAR: FGR: fyn: Lyn: Hck: CR3_enti_e41
chemoattrcatant: uPAR: FGR: fyn: Lyn: Hck: CR3
Lyn_enti_MO000000144
Lyn
chemoattractant_enti_e42
chemoattractant
Shc: Lyn: p85:p110: PI3K_enti_e43
Shc: Lyn: p85:p110: PI3K
Shc: Lyn: p85:p110: PI3K{activated}_enti_e44
Shc: Lyn: p85:p110: PI3K{activated}
SDF-1_enti_MO000019001
SDF-1
CXCR4_enti_MO000017157
CXCR4
SDF-1: CXCR4_enti_e45
SDF-1: CXCR4
SDF-1: CXCR4: Lyn: PI3K_enti_e46
SDF-1: CXCR4: Lyn: PI3K
SHP-2_enti_MO000016886
SHP-2
SDF-1: CXCR4: SHP-2: c-Cbl: Fyn_enti_e47
SDF-1: CXCR4: SHP-2: c-Cbl: Fyn
chemoattractant: chemoattractant receptor_enti_e48
chemoattractant: chemoattractant receptor
chemoattractant: chemoattractant receptor: Fyn_enti_e49
chemoattractant: chemoattractant receptor: Fyn
chemoattractant: chemoattractant receptor: Fyn: Fyn_enti_e63
chemoattractant: chemoattractant receptor: Fyn: Fyn
chemoattractant: chemoattractant receptor: Fyn: Fyn_enti_e64
chemoattractant: chemoattractant receptor: Fyn: Fyn
chemoattractant receptor_enti_e65
chemoattractant receptor
MIP-1beta_enti_MO000019951
MIP-1beta
CCR5_enti_MO000017281
CCR5
MIP-1beta: CCR5_enti_e66
MIP-1beta: CCR5
MIP-1beta: CCR5: SyK_enti_e67
MIP-1beta: CCR5: SyK
CR3_enti_MO000064543
CR3
Pyk2_enti_MO000016852
Pyk2
FGR: Pyk2_enti_e68
FGR: Pyk2
Src_enti_MO000000085
Src
Src: Pyk2_enti_e69
Src: Pyk2
Src: c-Cbl_enti_e70
Src: c-Cbl
Lyn: c-Cbl_enti_e71
Lyn: c-Cbl
p190RhoGAP_enti_MO000036287
p190RhoGAP
Pyk2: p190RhoGAP_enti_e72
Pyk2: p190RhoGAP
Vav_enti_MO000000044
Vav
Vav{p}_enti_e73
Vav{p}
cortactin_enti_MO000016997
cortactin
Arp2/3 complex_enti_MO000019632
Arp2/3 complex
FGR: Pyk2{p}_enti_e74
FGR: Pyk2{p}
Pyk2{p}_enti_e75
Pyk2{p}
Src: c-Cbl{p}_enti_e76
Src: c-Cbl{p}
Lyn: c-Cbl{p}_enti_e77
Lyn: c-Cbl{p}
p190RhoGAP{p}_enti_e79
p190RhoGAP{p}
Cdc42:GTP_enti_MO000019718
Cdc42:GTP
Cdc42:GDP_enti_MO000019719
Cdc42:GDP
Rac: GDP_enti_e80
Rac: GDP
Rac:GTP_enti_e81
Rac:GTP
WASP_enti_MO000017852
WASP
actin_enti_MO000016998
actin
WASP_enti_e82
WASP
actin polymer_enti_e83
actin polymer
paxillin_enti_MO000017529
paxillin
paxillin{p}_enti_e84
paxillin{p}
c-Cbl: Syk_enti_e85
c-Cbl: Syk
ROI_enti_e86
ROI
P selectin_enti_e87
P selectin
PSGL-1_enti_MO000012555
PSGL-1
P selectin: PSGL-1_enti_e88
P selectin: PSGL-1
ligand: beta2-integrin_enti_e89
ligand: beta2-integrin
TYROBP_enti_MO000066771
TYROBP
LFA-1: GPCR_enti_e90
LFA-1: GPCR
GPCR_enti_MO000000314
GPCR
LFA-1_enti_e91
LFA-1
proinflammatory mediator_enti_e92
proinflammatory mediator
superoxide anion_enti_e93
superoxide anion
counter receptor for leukocyte_enti_e94
counter receptor for leukocyte
cortactin: Arp2/3 complex_enti_e95
cortactin: Arp2/3 complex
cortactin {p}_enti_e96
cortactin {p}
Pyk2: c-Cbl_enti_e98
Pyk2: c-Cbl
Pyk2: c-Cbl{p}_enti_e99
Pyk2: c-Cbl{p}
Fyn: c-Cbl_enti_e97
Fyn: c-Cbl
Fyn: c-Cbl{p}_enti_e100
Fyn: c-Cbl{p}
Src family: c-Cbl_enti_e101
Src family: c-Cbl
Src family: Pyk2:c-Cbl: p190RhoGAP_enti_e78
Src family: Pyk2:c-Cbl: p190RhoGAP
Src family: c-Cbl{p}_enti_e102
Src family: c-Cbl{p}
Src family: c-Cbl{p}: Pyk2_enti_e103
Src family: c-Cbl{p}: Pyk2
ligand:beta1-integrin: Hck_enti_e104
ligand:beta1-integrin: Hck
ligand:beta1-integrin_enti_e105
ligand:beta1-integrin
ligand:beta1-integrin: Fgr_enti_e106
ligand:beta1-integrin: Fgr
E selectin_enti_e107
E selectin
E selectin: PSGL-1_enti_e108
E selectin: PSGL-1
c-Cbl: Cap_enti_e109
c-Cbl: Cap
CAP_enti_MO000019573
CAP
PSGL-1:SELE:moesin: ezrin:SFK: Syk_enti_e110
PSGL-1:SELE:moesin: ezrin:SFK: Syk
PSGL-1:SELE: moesin{p}: ezrin{p}:SFK: Syk_enti_e111
PSGL-1:SELE: moesin{p}: ezrin{p}:SFK: Syk