1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18406367.csml convertedTime:2009.07.01.11:18

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Lipopolysaccharide sensing an important factor in the innate immune response toGram-negative bacterial infections: benefits and hazards of LPShypersensitivity.
Authors Freudenberg MA, Tchaptchet S, Keck S, Fejer G, Huber M, Schutze N, Beutler B,Galanos C.
Affiliation Max-Planck-Institute for Immunobiology, Stubeweg 51, D-79108 Freiburg, Germany.freudenberg@immunobio.mpg.de
Abstract In this review, we summarize our investigations concerning the differentialimportance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloiddifferentiation protein-2 (MD-2)-mediated signaling by smooth and rough-formlipopolysaccharide (LPS) chemotypes and include the results obtained in studieswith murine and human TLR4-transgenic mice. Furthermore, we present more recentdata on the mechanisms involved in the induction of LPS hypersensitivity bybacterial and viral infections and on the reactivity of the hypersensitive hostto non-LPS microbial ligands and endogenous mediators. Finally, the effects ofpre-existing hypersensitivity on the course and outcome of a super-infectionwith Salmonella typhimurium or Listeria monocytogenes are summarized.
PMID 18406367
Model Abstract

Entity

G010228:IFN-beta G010262:IL-6 G010329:TNF-alpha G010453:IFN-gamma G010657:IL-12 p40 MO000016573:MyD88 MO000016625:IL-18 MO000017181:STAT4 MO000017265:IL-12 MO000018132:CD14 MO000019394:TLR4 MO000019398:TLR3 MO000019420:LBP MO000021928:S form-LPS:LBP MO000021929:S-formLPS:LBP:CD14 MO000022131:MD-2 MO000022224:dsRNA MO000033676:IL-12R MO000038482:IFNalpha, IFNbeta MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000042012:TLR9 MO000042032:PGN MO000068831:MAL MO000103999:mda-5 e1: e10: e11:TLR4: MD-2 e12:S form-LPS:LBP:CD14: TLR4: MD-2 e13:R form-LPS: TLR4: MD-2 e14:lipid A e15:lipid A: TLR4: MD-2 e16:IL-18R e17:IL-12 : IL-12R e18:LP e19:IL-18: IL-18R e2: e20:STAT4 {activated} e21:IFNalpha, IFNbeta [activated} e22:S form-LPS:LBP:CD14: TLR4: MD-2: MyD88: MAL e23:S form-LPS:LBP:CD14: TLR4: MD-2: TRIF: TRAM e24:IFN-alpha e25:TLR2:TLR1 e26:TLR2: TLR6 e28:LTA e29:LP: TLR2:TLR1 e3: e30:PGN: TLR2:TLR1 e31:LTA: TLR2:TLR1 e32:LP: TLR2: TLR6 e33:PGN: TLR2: TLR6 e34:LTA: TLR2: TLR6 e35:dsRNA: mda-5 e36:TLR9 ligand e37:TLR9 ligand: TLR9 e38:IL-12p35 e39:IL-12Rbeta1 e4: e40:IL-12Rbeta2 e5:R form-LPS e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:S form-LPS e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p4 p5 p6 p7 p8 p9
Model Detail
478.0, 1000.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p17 p30

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
607.0, 991.0
26.0, 26.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p16 p27

--

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
526.0, 992.0
27.0, 27.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p15 p28

--

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
664.0, 1048.0
31.0, 31.0

IFN-gamma

--

G010453

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p9 p12

--

true true true true

csml-variable:Double

m93423

10

false

infinite

0

unit false false false
TRANSFACG010453

--

Go back
434.0, 1126.0
28.0, 28.0

IL-12 p40

--

G010657

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m93589

10

false

infinite

0

unit false false false
TRANSFACG010657

--

Go back
648.0, 250.0
32.5, 32.5

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1056.0, 1120.0
32.0, 32.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
660.0, 1140.0
32.0, 32.0

STAT4

--

MO000017181

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m2053

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000017181

--

Go back
1049.0, 885.0
30.0, 30.0

IL-12

--

MO000017265

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m2121

10

false

infinite

0

unit false false false
TRANSPATHMO000017265

--

Go back
284.0, 130.0
32.0, 32.0

CD14

--

MO000018132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m2828

10

false

infinite

0

unit false false false
InterProIPR001611
TRANSPATHMO000018132

--

Go back
407.0, 173.0
26.0, 26.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
970.0, 250.0
28.0, 28.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
355.0, 29.0
34.0, 34.0

LBP

--

MO000019420

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3985

10

false

infinite

0

unit false false false
InterProIPR001124
TRANSPATHMO000019420

--

Go back
283.0, 85.0
34.0, 34.0

S form-LPS:LBP

--

MO000021928

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2

true true true true

csml-variable:Double

m6254

10

false

infinite

0

unit false false false
TRANSPATHMO000021928

--

Go back
350.0, 168.0
36.5, 36.5

S-formLPS:LBP:CD14

--

MO000021929

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p4

true true true true

csml-variable:Double

m6255

10

false

infinite

0

unit false false false
TRANSPATHMO000021929

--

Go back
448.0, 170.0
32.0, 32.0

MD-2

--

MO000022131

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m6438

10

false

infinite

0

unit false false false
InterProIPR003172
TRANSPATHMO000022131

--

Go back
1048.0, 228.0
38.0, 38.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p31

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
964.0, 848.0
32.0, 32.0

IL-12R

--

MO000033676

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m12340

10

false

infinite

0

unit false false false
TRANSPATHMO000033676

--

Go back
890.0, 1140.0
28.0, 28.0

IFNalpha, IFNbeta

--

MO000038482

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m16692

10

false

infinite

0

unit false false false
TRANSPATHMO000038482

--

Go back
750.0, 290.0
27.0, 27.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p26

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
717.0, 245.0
30.0, 30.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
958.0, 386.0
36.0, 36.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p27 p28

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
960.0, 292.0
32.0, 32.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p26

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
173.0, 1117.0
29.0, 29.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
51.0, 463.0
25.0, 25.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20 p23

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
594.0, 250.0
35.5, 35.5

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
895.0, 567.0
33.0, 33.0

mda-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
157.75, 172.9969080091176
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
166.0, 192.0
829.9775981223105, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
508.5, 163.0
31.689551741376437, 38.80353274454258

TLR4: MD-2

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4 p5 p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
572.25, 157.0
30.567168287759223, 42.65186272710589

S form-LPS:LBP:CD14: TLR4: MD-2

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p4

p13 p14 p17 p18

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
928.25, 139.0
38.89254909157643, 54.26867315103687

R form-LPS: TLR4: MD-2

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p5

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
181.0, 73.5
30.0, 17.0

lipid A

--

e14

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
195.25, 158.0
25.158188993641748, 48.69326901995176

lipid A: TLR4: MD-2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
962.0, 1122.0
36.0, 36.0

IL-18R

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
InterProIPR003599
TRANSPATHMO000016602

--

Go back
974.25, 935.0
27.46228897171673, 53.15281736461302

IL-12 : IL-12R

--

e17

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p9

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
51.0, 391.5
33.440000000000005, 25.080000000000002

LP

--

e18

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p19 p21

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
971.25, 1024.0
25.239750054812543, 48.85112913834685

IL-18: IL-18R

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p11

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
157.75, 172.9969080091176
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
660.0, 1096.0
32.0, 32.0

STAT4 {activated}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p12

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000017181

--

Go back
834.0, 1098.0
28.0, 28.0

IFNalpha, IFNbeta [activated}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11

p10

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000038482

--

Go back
683.5, 137.0
41.57166452560102, 58.0069737566526

S form-LPS:LBP:CD14: TLR4: MD-2: MyD88: MAL

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p15

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
795.875, 149.5
40.16503028078546, 56.044228298770406

S form-LPS:LBP:CD14: TLR4: MD-2: TRIF: TRAM

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p16

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
431.0, 1021.0
25.0, 25.0

IFN-alpha

--

e24

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18 p29

--

true true true true

csml-variable:Double

m24

10

false

infinite

0

unit false false false
EnsemblENSG00000147877
HGNCIFNA7
OMIM147567
ProteomeHumanPSD/IFNA7
RefSeqNM_021057
TRANSFACG000306
UnigeneHs.282274

--

Go back
170.0, 326.0
36.0, 36.0

TLR2:TLR1

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19 p20 p24

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000042221

--

Go back
169.625, 581.5
36.75, 45.0

TLR2: TLR6

--

e26

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p21 p22 p23

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
41.5, 519.25
45.0, 25.5

LTA

--

e28

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p22 p24

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
168.75, 271.5
29.9585635359116, 33.28729281767956

LP: TLR2:TLR1

--

e29

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
174.87518862352903, 190.12209663264667
822.0090539293948, 1209.0383168211513

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
169.75, 392.5
28.118784530386737, 31.24309392265194

PGN: TLR2:TLR1

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
172.75, 439.5
29.9585635359116, 33.287292817679564

LTA: TLR2:TLR1

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p24

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
169.75, 488.5
28.267955801104975, 31.408839779005536

LP: TLR2: TLR6

--

e32

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
170.75, 533.5
26.32872928176796, 29.25414364640884

PGN: TLR2: TLR6

--

e33

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p23

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
169.75, 651.5
29.013812154696137, 32.23756906077349

LTA: TLR2: TLR6

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p22

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
893.625, 717.5
36.75, 45.0

dsRNA: mda-5

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p31

p29 p30

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
100.5, 1263.375
39.37609841827767, 25.59446397188049

TLR9 ligand

--

e36

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p32

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
177.375, 1179.5
29.040835343126506, 56.20806840605131

TLR9 ligand: TLR9

--

e37

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p32

p33 p34 p35 p36

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
461.5, 1172.0
45.0, 24.0

IL-12p35

--

e38

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p34

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
513.5, 1208.0
45.0, 24.0

IL-12Rbeta1

--

e39

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p35

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
206.5567875770579, 220.09117672382234
758.6458560223374, 1149.1001566387988

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
561.5, 1248.0
45.0, 24.0

IL-12Rbeta2

--

e40

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p36

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
988.0, 38.0
32.0, 32.0

R form-LPS

--

e5

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
339.0, 890.0
465.6500709748862, 422.29345356567933

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
389.29367619468036, 900.0077409313898
272.27955732982184, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
345.06992643728904, 895.6363602631969
453.51021810030846, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
345.93705878547314, 896.503492611381
451.7759534039399, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
339.0, 890.0
465.6500709748862, 422.29345356567933

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
339.0, 890.0
465.6500709748862, 422.29345356567933

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
345.93705878547314, 896.503492611381
451.7759534039399, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
678.9158804881849, 1063.426469636829
29.091257918298922, 26.33524401024959

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
602.6082338479803, 1184.8249983826097
82.37757307749382, 74.57338194383664

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
339.0, 890.0
465.6500709748862, 422.29345356567933

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
213.0, 31.0
30.0, 30.0

S form-LPS

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
TRANSPATHMO000042409

--

Go back
448.7511016961721, 1077.6637213250547
14.746453546866459, 7.100144300343119

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
448.25867587120234, 1056.489410851356
50.4736470593979, 90.85256470691624

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
469.43298634490145, 1115.5805098477247
7.878813199515761, 7.8788131995157675

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
169.0, 178.0
839.7237354966342, 1189.8668429177399

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
172.0, 199.0
805.5569854171277, 1169.6687428256696

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
180.0, 220.0
801.8791759029863, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
281.0, 31.0
31.0, 31.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e6 MO000019420

MO000021928

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1

m6*m3985*0.1

nodelay

--

true

0

false

PMID: 18406367, 16506285 activation of TLR4 by S-form LPS requires the cooperation of accessory proteins (CD14, LBP), while R-form LPS can trigger the TLR4/MD-2 directly.

Go back
741.0, 1097.0
30.0, 30.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Nucleoplasm

--

MO000017181 e21

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c32 : 1
stoichiometry:c28 : 1

m2053*m21*0.1

nodelay

--

true

0

false

PMID: 18406367, 12165484 In addition to the IL-12-dependent pathway, we reported the existence of a further, IL-12-independent pathway of IFN-gamma induction based on activation of the signal transducer and activator of transcription (STAT)4 by IFN-alpha/beta and IL-18 signaling.

Go back
889.0, 1035.0
30.0, 30.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000038482 e19

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m16692*m19*0.1

nodelay

--

true

0

false

PMID: 18406367, 12165484 In addition to the IL-12-dependent pathway, we reported the existence of a further, IL-12-independent pathway of IFN-gamma induction based on activation of the signal transducer and activator of transcription (STAT)4 by IFN-alpha/beta and IL-18 signaling.

Go back
743.0, 1051.0
25.0, 25.0

p12

p12

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e20

G010453

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18406367, 12165484 In addition to the IL-12-dependent pathway, we reported the existence of a further, IL-12-independent pathway of IFN-gamma induction based on activation of the signal transducer and activator of transcription (STAT)4 by IFN-alpha/beta and IL-18 signaling.

Go back
626.0, 188.0
27.0, 27.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

MO000016573 e12 MO000068831

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c35 : 1
stoichiometry:c38 : 1

m1572*m12*m43675*0.1

nodelay

--

true

0

false

PMID: 18406367, 12872135, 16924467 LPS induction of pro-inflammatory cytokines, such as TNF-alpha or IL-6 via TLR4 requires the assistance of the adapter proteins MyD88 and TRIF, in association with Mal and TRAM, respectively, whereby the induction of IFN-alpha/beta is MyD88/Mal independent.

Go back
745.0, 171.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e12 MO000041132 MO000041125

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m12*m19005*m18998*0.1

nodelay

--

true

0

false

PMID: 18406367, 12872135, 16924467 LPS induction of pro-inflammatory cytokines, such as TNF-alpha or IL-6 via TLR4 requires the assistance of the adapter proteins MyD88 and TRIF, in association with Mal and TRAM, respectively, whereby the induction of IFN-alpha/beta is MyD88/Mal independent.

Go back
527.0, 937.0
25.0, 25.0

p15

p15

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e22

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c43 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 18406367, 12872135, 16924467 LPS induction of pro-inflammatory cytokines, such as TNF-alpha or IL-6 via TLR4 requires the assistance of the adapter proteins MyD88 and TRIF, in association with Mal and TRAM, respectively, whereby the induction of IFN-alpha/beta is MyD88/Mal independent.

Go back
607.0, 939.0
25.0, 25.0

p16

p16

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e23

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c44 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18406367, 12872135, 16924467 LPS induction of pro-inflammatory cytokines, such as TNF-alpha or IL-6 via TLR4 requires the assistance of the adapter proteins MyD88 and TRIF, in association with Mal and TRAM, respectively, whereby the induction of IFN-alpha/beta is MyD88/Mal independent.

Go back
480.0, 950.0
23.0, 23.0

p17

p17

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e12

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c50 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18406367, 12872135, 16924467 LPS induction of pro-inflammatory cytokines, such as TNF-alpha or IL-6 via TLR4 requires the assistance of the adapter proteins MyD88 and TRIF, in association with Mal and TRAM, respectively, whereby the induction of IFN-alpha/beta is MyD88/Mal independent.

Go back
432.0, 962.0
23.0, 23.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e12

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1

m12*0.1

nodelay

--

true

0

false

PMID: 18406367, 12872135, 16924467 LPS induction of pro-inflammatory cytokines, such as TNF-alpha or IL-6 via TLR4 requires the assistance of the adapter proteins MyD88 and TRIF, in association with Mal and TRAM, respectively, whereby the induction of IFN-alpha/beta is MyD88/Mal independent.

Go back
56.0, 332.0
23.0, 23.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e25 e18

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c62 : 1

m25*m18*0.1

nodelay

--

true

0

false

PMID: 18406367, 16924467 LP, depending on their chemical structure, are ligands of the heterodimeric surface receptors TLR2/TLR6 or TLR2/TLR1.

Go back
353.0, 87.0
30.0, 30.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021928 MO000018132

MO000021929

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m6254*m2828*0.1

nodelay

--

true

0

false

PMID: 18406367, 16506285 activation of TLR4 by S-form LPS requires the cooperation of accessory proteins (CD14, LBP), while R-form LPS can trigger the TLR4/MD-2 directly.

Go back
107.0, 395.0
25.0, 25.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e25 MO000042032

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c54 : 1
stoichiometry:c63 : 1

m25*m155701*0.1

nodelay

--

true

0

false

PMID: 18406367, 10549626, 10588727 The cytokine responses to S. aureus were suggested earlier to be TLR2 dependent, since peptidoglycan and lipoteichoic acid isolated from this micro-organism were shown to trigger this receptor.

Go back
111.0, 491.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 e18

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c65 : 1

m26*m18*0.1

nodelay

--

true

0

false

PMID: 18406367, 16924467 LP, depending on their chemical structure, are ligands of the heterodimeric surface receptors TLR2/TLR6 or TLR2/TLR1.

Go back
51.0, 591.0
25.0, 25.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 e28

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m26*m28*0.1

nodelay

--

true

0

false

PMID: 18406367, 10549626, 10588727 The cytokine responses to S. aureus were suggested earlier to be TLR2 dependent, since peptidoglycan and lipoteichoic acid isolated from this micro-organism were shown to trigger this receptor.

Go back
106.0, 534.0
27.0, 27.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 MO000042032

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c66 : 1

m26*m155701*0.1

nodelay

--

true

0

false

PMID: 18406367, 10549626, 10588727 The cytokine responses to S. aureus were suggested earlier to be TLR2 dependent, since peptidoglycan and lipoteichoic acid isolated from this micro-organism were shown to trigger this receptor.

Go back
111.0, 443.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e25 e28

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c64 : 1

m25*m28*0.1

nodelay

--

true

0

false

PMID: 18406367, 10549626, 10588727 The cytokine responses to S. aureus were suggested earlier to be TLR2 dependent, since peptidoglycan and lipoteichoic acid isolated from this micro-organism were shown to trigger this receptor.

Go back
1027.0, 291.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c74 : 1
stoichiometry:c70 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18406367 Since TRIF function is absolutely necessary for TLR3 signaling, our findings indicate that the role of TLR3 in the recognition of dsRNA had been overestimated in the past.

Go back
1027.0, 359.0
25.0, 25.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c73 : 1
stoichiometry:c72 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18406367 Since TRIF function is absolutely necessary for TLR3 signaling, our findings indicate that the role of TLR3 in the recognition of dsRNA had been overestimated in the past.

Go back
648.0, 944.0
23.0, 23.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c76 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 18406367 priming with P. acnes enhanced only moderately the TNF-alpha and IL-6 responses to dsRNA and caused no enhancement of the IFN-alpha/beta response.

Go back
568.0, 944.0
23.0, 23.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041437

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c75 : 1

m19305*0.1

nodelay

--

true

0

false

PMID: 18406367 priming with P. acnes enhanced only moderately the TNF-alpha and IL-6 responses to dsRNA and caused no enhancement of the IFN-alpha/beta response.

Go back
430.0, 1074.0
27.0, 27.0

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e35

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c79 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 184066367, 16730994 the cytoplasmic melanoma differentiation-associated gene-5 (mda-5) is the dominant receptor mediating the IFN-alpha/beta responses to dsRNA.

Go back
449.0, 95.0
30.0, 30.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000022131

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3961*m6438*0.1

nodelay

--

true

0

false

PMID: 18406367, 11500507, 17803912 In this function, TLR4 is aided by the LPS recognition protein MD (myeloid differentiation protein)-2.

Go back
478.0, 1074.0
27.0, 27.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c80 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 184066367, 16730994 the cytoplasmic melanoma differentiation-associated gene-5 (mda-5) is the dominant receptor mediating the IFN-alpha/beta responses to dsRNA.

Go back
898.0, 630.0
27.0, 27.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000103999

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m119368*m76904*0.1

nodelay

--

true

0

false

PMID: 184066367, 16730994 the cytoplasmic melanoma differentiation-associated gene-5 (mda-5) is the dominant receptor mediating the IFN-alpha/beta responses to dsRNA.

Go back
105.0, 1193.0
30.0, 30.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e36 MO000042012

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m36*m19828*0.1

nodelay

--

true

0

false

PMID: 18406367 induction of mRNA for IL-12p40, IL-12p35, IL-12Rbeta1 and IL-12Rbeta2 was also absent in the liver of TLR9¡Ý/¡Ý mice, 3 days after P. acnes treatment.

Go back
379.0, 1131.0
25.0, 25.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

G010657

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c89 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18406367 induction of mRNA for IL-12p40, IL-12p35, IL-12Rbeta1 and IL-12Rbeta2 was also absent in the liver of TLR9¡Ý/¡Ý mice, 3 days after P. acnes treatment.

Go back
405.0, 1189.0
23.0, 23.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c90 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18406367 induction of mRNA for IL-12p40, IL-12p35, IL-12Rbeta1 and IL-12Rbeta2 was also absent in the liver of TLR9¡Ý/¡Ý mice, 3 days after P. acnes treatment.

Go back
453.0, 1225.0
27.0, 27.0

p35

p35

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c91 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18406367 induction of mRNA for IL-12p40, IL-12p35, IL-12Rbeta1 and IL-12Rbeta2 was also absent in the liver of TLR9¡Ý/¡Ý mice, 3 days after P. acnes treatment.

Go back
516.0, 1256.0
23.0, 23.0

p36

p36

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e37

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c92 : 1

m37*0.1

nodelay

--

true

0

false

PMID: 18406367 induction of mRNA for IL-12p40, IL-12p35, IL-12Rbeta1 and IL-12Rbeta2 was also absent in the liver of TLR9¡Ý/¡Ý mice, 3 days after P. acnes treatment.

Go back
509.0, 67.0
30.0, 30.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000021929 e11

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m6255*m11*0.1

nodelay

--

true

0

false

PMID: 18406367, 15608698, 2402637, 1698311 The activation of TLR4 is assisted further by the plasma protein LBP (LPS-binding protein). PMID: 18406367 According to the current consensus, recognition of LPS by cells of the innate immune system proceeds via the LPS receptor complex, which, in addition to the signaling subunit TLR4, consists of recognition subunits MD-2 and glycosyl-phosphatidylinositol-anchored CD14 (mCD14).

Go back
933.0, 39.0
30.0, 30.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 e11

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m5*m11*0.1

nodelay

--

true

0

false

PMID: 18406367, 16506285 activation of TLR4 by S-form LPS requires the cooperation of accessory proteins (CD14, LBP), while R-form LPS can trigger the TLR4/MD-2 directly.

Go back
229.0, 107.0
30.0, 30.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 e11

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m14*m11*0.1

nodelay

--

true

0

false

PMID: 18406367, 6714230, 324763 Furthermore, while cells (e.g., macrophages and B cells) carrying murine or human TLR4 can be stimulated with lipid A, only those carrying the murine receptor respond to the lipid A precursor (tetra-acylated lipid A).

Go back
1049.0, 947.0
30.0, 30.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000017265 MO000033676

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c19 : 1
stoichiometry:c21 : 1

m2121*m12340*0.1

nodelay

--

true

0

false

PMID: 18406367, 9755338, 9620656 The induction of IFN-gamma is complex. Induction by bacteria is dependent on interleukin (IL)-12 and IL-18.

Go back
1057.0, 1033.0
30.0, 30.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000016625 e16

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c22 : 1
stoichiometry:c24 : 1

m1611*m16*0.1

nodelay

--

true

0

false

PMID: 18406367, 12165484 In addition to the IL-12-dependent pathway, we reported the existence of a further, IL-12-independent pathway of IFN-gamma induction based on activation of the signal transducer and activator of transcription (STAT)4 by IFN-alpha/beta and IL-18 signaling.

Go back
723.0, 1015.0
25.0, 25.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e17

G010453

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18406367, 9755338, 9620656 The induction of IFN-gamma is complex. Induction by bacteria is dependent on interleukin (IL)-12 and IL-18.

Go back
243.0, 46.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.0, 82.00869422222094

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.0, 105.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 97.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.0, 54.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.0, 54.01020964533277

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
948.0, 69.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
206.0, 91.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
243.91160400162784, 144.99999666689658

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.23999152002546, 137.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
994.0, 880.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.0, 62.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1064.0, 915.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1010.0, 962.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.0, 1068.6568542494924

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1072.0, 1071.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1004.0, 1048.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.7405743333039, 966.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
701.7294278030124, 1036.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.0, 1123.860838029177

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
700.0, 1112.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 1073.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.9978375455748, 46.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
866.3813823519705, 1065.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
926.9940893970505, 1048.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 1112.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
692.0, 1076.0561610125071

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
703.0, 1064.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 222.35316024014446

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
647.785492236829, 222.49940217607812

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 185.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.0, 181.84666088965483

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
597.0, 101.77500466904411

c39

c39

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
317.0, 102.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.0, 203.55805289534106

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 180.91699286388103

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.3401177329985, 203.99276672546497

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.0, 962.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 964.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
544.6358483164947, 195.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
624.9676533007531, 206.0

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.4256285830347, 200.0

c47

c47

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
493.97403250719435, 200.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
444.0, 985.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
316.0, 116.35352884079218

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 973.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.0, 344.0

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
68.0, 363.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
137.80762147124662, 361.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 426.20449602968955

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
136.29500393754526, 522.7492919018569

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
75.0, 417.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.21404598975602, 564.0384156673698

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
73.0, 488.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
84.0, 604.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 117.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
135.0150230995983, 362.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
74.0, 474.29482733884726

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
79.0, 298.51368105603956

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
132.0, 408.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
136.0, 456.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
136.0, 504.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
133.0, 548.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
64.0, 545.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
76.0, 610.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.0, 274.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
427.0, 131.91023120718748

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
999.9869706753918, 305.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
992.0, 324.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.1117964514128, 378.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.0, 307.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1049.4618485406781, 266.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
555.9975603804354, 967.0

c75

c75

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.1214751973158, 967.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.6593284228757, 422.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
670.9762701620235, 422.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
444.0, 1054.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.0, 133.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 1036.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
932.9999849839868, 266.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.0, 600.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
912.0, 657.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
463.42637286961354, 754.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
511.16261788996053, 755.0

c85

c85

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
120.0, 1231.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
138.33064786824195, 1146.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
135.0, 1208.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.0, 1141.53215208419

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
477.0, 125.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
428.0, 1191.8323146698044

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
480.0, 1228.0471404825303

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
539.0, 1264.034713472542

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
206.0, 1150.4238101946487

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
206.0, 1201.281233098133

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
206.0, 1210.0

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
206.0, 1211.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back