1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18407061.csml convertedTime:2009.07.01.11:19

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Linking inflammasome activation and phagosome maturation.
Authors Lazarevic V, Martinon F.
Affiliation Department of Immunology and Infectious Diseases, Harvard School of PublicHealth, 651 Huntington Avenue, Boston, MA 02115, USA.
Abstract One-third of the world's population is infected with Mycobacterium tuberculosis,one of the most effective human pathogens, whose success is attributed to thedeployment of remarkably sophisticated immune evasion mechanisms. In this issueof Cell Host & Microbe, a new study unravels a novel strategy of immune evasionand enhanced bacterial intracellular survival, which is dependent on inhibitionof inflammasome activation by an M. tuberculosis-encoded metalloprotease.
PMID 18407061
Model Abstract

Entity

MO000000030:PI3K MO000007330:proIL-18 MO000016597:IL-1beta MO000016625:IL-18 MO000016828:Caspase-1 MO000019449:proIL-1beta MO000022185:flagellin MO000044014:ASC e1: e10: e11:IPAF inflammasome e12:NALP3 inflammasome {activated} e13:NALP1B inflammasome e14:NALP1B inflammasome {activated} e15:IPAF inflammasome {activated} e16:NALP3 inflammasome {activated}: ASC e17:NAIP5 inflammasome {activated}: ASC e18:NALP3 inflammasome {activated}: ASC: caspase-1 {activated} e19:IPAF inflammasome {activated}: ASC e2: e20:NAIP5 inflammasome {activated} e21:IL-1beta {extracellular} e22:IL-1R: IL-1beta e23:NALP3 inflammasome {activated}: ASC: caspase-1 e24:NAIP5 inflammasome {activated}: ASC: caspase-1 e25:NAIP5 inflammasome {activated}: ASC: caspase-1{activated} e26:IPAF inflammasome {activated}: ASC: caspase-1 e27:IL-1R e28:IPAF inflammasome {activated}: ASC: caspase-1{activated} e29:anthrax lethal toxin e3: e30:listeriolysin O toxin e31:bacterial protein e32:Mycobacterium tuberculosis protein e33:PI3K {activated} e4: e5:NALP3 inflammasome e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:NAIP5 inflammasome e60: e61: e62: e7: e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p3 p4 p5 p6 p7 p8 p9
Model Detail
777.0, 853.0
38.0, 38.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m30

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
513.0, 741.0
30.0, 30.0

proIL-18

--

MO000007330

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10 p18 p19

true true true true

csml-variable:Double

m841

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000007330

--

Go back
848.0, 772.0
32.0, 32.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p11 p21 p23

p12 p22

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
633.0, 745.0
29.0, 29.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10 p18 p19

--

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
570.0, 486.0
36.5, 36.5

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p15 p17

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
754.0, 774.0
28.0, 28.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p21 p23

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
49.0, 497.0
30.0, 30.0

flagellin

--

MO000022185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m6485

10

false

infinite

0

unit false false false
TRANSPATHMO000022185

--

Go back
394.0, 486.0
28.0, 28.0

ASC

--

MO000044014

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p4 p6

true true true true

csml-variable:Double

m21736

10

false

infinite

0

unit false false false
InterProIPR004020
TRANSPATHMO000044014

--

Go back
117.75, 91.99690800911765
856.2594311764528, 1243.2886940682085

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
126.0, 111.00000000000006
829.9775981223106, 1167.545103664102

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
245.875, 489.5
32.25, 45.0

IPAF inflammasome

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p7 p8

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
243.875, 293.5
32.25, 45.0

NALP3 inflammasome {activated}

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p1

p3

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
253.875, 667.5
32.25, 45.0

NALP1B inflammasome

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
253.875, 735.5
32.25, 45.0

NALP1B inflammasome {activated}

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
245.875, 553.5
32.25, 45.0

IPAF inflammasome {activated}

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p7 p8

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
467.875, 293.5
32.25, 45.0

NALP3 inflammasome {activated}: ASC

--

e16

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p14

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
467.875, 417.5
32.25, 45.0

NAIP5 inflammasome {activated}: ASC

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p15

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
859.875, 393.5
32.25, 45.0

NALP3 inflammasome {activated}: ASC: caspase-1 {activated}

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p19 p23

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
463.875, 553.5
32.25, 45.0

IPAF inflammasome {activated}: ASC

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

p6

p17

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
117.75, 91.99690800911765
856.2594311764528, 1243.2886940682085

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
243.875, 417.5
32.25, 45.0

NAIP5 inflammasome {activated}

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p4

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1044.0, 772.0
32.0, 32.0

IL-1beta {extracellular}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p12

p13

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
925.625, 917.5
36.929636727212134, 45.219963339443424

IL-1R: IL-1beta

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
631.875, 341.5
32.25, 45.0

NALP3 inflammasome {activated}: ASC: caspase-1

--

e23

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p5

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
631.875, 409.5
32.25, 45.0

NAIP5 inflammasome {activated}: ASC: caspase-1

--

e24

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p16

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
859.875, 469.5
32.25, 45.0

NAIP5 inflammasome {activated}: ASC: caspase-1{activated}

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

p18 p21

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
627.875, 533.5
32.25, 45.0

IPAF inflammasome {activated}: ASC: caspase-1

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p20

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
929.0, 837.0
30.0, 30.0

IL-1R

--

e27

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR004076
TRANSPATHMO000016595

--

Go back
859.875, 593.5
32.25, 45.0

IPAF inflammasome {activated}: ASC: caspase-1{activated}

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p10 p11

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
39.5, 744.25
41.54331370899916, 23.541211101766187

anthrax lethal toxin

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
134.87518862352903, 109.12209663264673
822.009053929395, 1209.038316821151

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
44.5, 305.25
38.313708999158955, 21.711101766190076

listeriolysin O toxin

--

e30

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
47.5, 429.375
33.96309314586994, 22.076010544815464

bacterial protein

--

e31

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
40.5, 567.375
39.37609841827767, 25.59446397188049

Mycobacterium tuberculosis protein

--

e32

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p8

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
849.0, 929.0
38.0, 38.0

PI3K {activated}

--

e33

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

--

true true true true

csml-variable:Double

m34

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
166.5567875770579, 139.0911767238224
758.6458560223377, 1149.1001566387986

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
243.875, 229.5
32.25, 45.0

NALP3 inflammasome

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
299.0000000000001, 809.0
465.65007097488615, 422.2934535656795

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
349.2936761946805, 819.0077409313899
272.2795573298219, 409.2864683429171

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
305.06992643728915, 814.6363602631968
453.5102181003086, 411.0207330392853

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
305.9370587854733, 815.5034926113808
451.77595340394004, 409.2864683429171

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
299.0000000000001, 809.0
465.65007097488615, 422.2934535656795

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
299.0000000000001, 809.0
465.65007097488615, 422.2934535656795

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
305.9370587854733, 815.5034926113808
451.77595340394004, 409.2864683429171

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
638.9158804881852, 982.4264696368291
29.09125791829892, 26.335244010249593

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
562.6082338479807, 1103.8249983826095
82.37757307749382, 74.57338194383665

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
299.0000000000001, 809.0
465.65007097488615, 422.2934535656795

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
243.875, 357.5
32.25, 45.0

NAIP5 inflammasome

--

e6

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
408.75110169617204, 996.6637213250547
14.746453546866464, 7.100144300343118

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
408.2586758712023, 975.4894108513563
50.4736470593979, 90.85256470691623

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
429.43298634490145, 1034.5805098477251
7.87881319951576, 7.878813199515771

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
129.0, 97.0
839.7237354966343, 1189.86684291774

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
132.0, 118.0
805.5569854171276, 1169.6687428256698

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
140.0, 139.0
801.8791759029862, 1154.3288303559784

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
191.0, 303.0
25.0, 25.0

p1

p1

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e5 e30

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c55 : 1
stoichiometry:c2 : 1

m5*m31*0.1

nodelay

--

true

0

false

PMID: 18407061 Vacuolar escape and listeriolysin O toxin were required for NALP3 inflammasome activation by Listeria monocytogenes.

Go back
635.0, 683.0
25.0, 25.0

p10

p10

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000007330 e28

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c50 : 1
stoichiometry:c24 : 1

m841*m28*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
850.0, 714.0
27.0, 27.0

p11

p11

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000019449 e28

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c53 : 1
stoichiometry:c26 : 1

m4012*m28*0.1

nodelay

--

true

0

false

PMID: 18407061 Inflammasome activation results in IL-1beta processing and release of IL-1beta that is followed by the engagement of its receptor (IL-1R).

Go back
935.0, 775.0
25.0, 25.0

p12

p12

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000016597

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1

m1591*0.1

nodelay

--

true

0

false

PMID: 18407061 Inflammasome activation results in IL-1beta processing and release of IL-1beta that is followed by the engagement of its receptor (IL-1R).

Go back
1047.0, 839.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 e27

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m21*m27*0.1

nodelay

--

true

0

false

PMID: 18407061 Inflammasome activation results in IL-1beta processing and release of IL-1beta that is followed by the engagement of its receptor (IL-1R).

Go back
531.0, 303.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e16 MO000016828

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c40 : 1
stoichiometry:c33 : 1

m16*m1765*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
531.0, 427.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e17 MO000016828

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c41 : 1
stoichiometry:c35 : 1

m17*m1765*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
695.0, 419.0
25.0, 25.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e24

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c37 : 1

m24*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
526.0, 562.0
27.0, 27.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e19 MO000016828

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c43 : 1
stoichiometry:c39 : 1

m19*m1765*0.1

nodelay

--

true

0

false

PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).

Go back
578.0, 678.0
27.0, 27.0

p18

p18

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000007330 e25

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c49 : 1
stoichiometry:c45 : 1

m841*m25*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
516.0, 684.0
23.0, 23.0

p19

p19

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000007330 e18

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m841*m18*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
201.0, 745.0
25.0, 25.0

p2

p2

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e13 e29

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c3 : 1
stoichiometry:c54 : 1
stoichiometry:c4 : 1

m13*m29*0.1

nodelay

--

true

0

false

PMID: 18407061 Bacillus anthracis uses anthrax lethal toxin to activate a NALP1b inflammasome.

Go back
694.0, 542.0
27.0, 27.0

p20

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c42 : 1

m26*0.1

nodelay

--

true

0

false

PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).

Go back
806.0, 714.0
27.0, 27.0

p21

p21

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000019449 e25

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c52 : 1
stoichiometry:c59 : 1

m4012*m25*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
853.0, 857.0
29.0, 29.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030 MO000016597

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m30*m1591*0.1

nodelay

--

true

0

false

PMID: 18407061 IL-1beta is known to activate PI3K, and it is tempting to speculate that the IL-1R signaling pathway and phagosome maturation pathway may converge at PI3K activation to promote PI3P generation.

Go back
753.0, 713.0
29.0, 29.0

p23

p23

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000019449 e18

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c51 : 1
stoichiometry:c63 : 1

m4012*m18*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
311.0, 303.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044014 e12

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c5 : 1
stoichiometry:c9 : 1
stoichiometry:c17 : 1

m21736*m12*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
315.0, 427.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044014 e20

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c10 : 1
stoichiometry:c18 : 1

m21736*m20*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
695.0, 351.0
25.0, 25.0

p5

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c36 : 1

m23*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
315.0, 563.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000044014 e15

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c12 : 1
stoichiometry:c20 : 1

m21736*m15*0.1

nodelay

--

true

0

false

PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).

Go back
193.0, 499.0
25.0, 25.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 MO000022185

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c57 : 1
stoichiometry:c14 : 1

m11*m6485*0.1

nodelay

--

true

0

false

PMID: 18407061, 17126540 IPAF and ASC have been previously associated with inflammasome activation by the Gram-negative bacteria Salmonella typhimurium, Shigella flexneri, and Pseudomonas aeruginosa, which use their type III secretion system to inject IPAF activators such as flagellin in the cytosol of macrophages.

Go back
193.0, 563.0
25.0, 25.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 e32

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c60 : 1
stoichiometry:c16 : 1

m11*m33*0.1

nodelay

--

true

0

false

PMID; 18407061 Infection with M. tuberculosis triggers IPAF inflammasome including the adaptor ASC and caspase-1 (Casp-1).

Go back
190.0, 426.0
27.0, 27.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 e31

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c56 : 1
stoichiometry:c22 : 1

m6*m32*0.1

nodelay

--

true

0

false

PMID: 18407061 The NLR family members NALP3, NAIP5, or IPAF and the adaptor ASC are involved in caspase-1 activation in response to bacterial infection, triggering the processing and maturation of IL-1beta and IL-18 cytokines.

Go back
220.28091686182944, 270.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 440.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 432.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
278.0, 576.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
226.0, 512.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
216.0, 524.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.28091686182944, 530.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
218.0, 576.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
336.0, 316.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 440.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.0, 556.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
216.0, 316.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
340.0, 576.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
222.45134822335075, 397.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
217.0, 440.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
543.0, 705.5777087639997

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
648.0, 708.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
782.0, 741.2039430457753

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
864.0, 741.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.0, 788.0

c27

c27

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 788.0

c28

c28

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1060.0, 804.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
230.1041429180026, 710.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.36345376026, 862.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
959.0, 852.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
500.0, 316.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 322.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
500.0, 440.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 433.6296198833601

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 368.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.0, 436.0

c37

c37

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 576.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
553.0, 560.4679769048231

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
226.0, 758.0

c4

c4

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
548.8240701714238, 335.7892726239182

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.6134655807892, 458.5357429061181

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
721.0, 561.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.4376015698018, 523.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.0, 710.6568542494924

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
603.0, 705.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.0, 715.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
539.0, 702.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
545.2355633212782, 429.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.5357429061181, 503.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
333.31736478473994, 335.2797727220682

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.5508668509282, 622.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
775.6206740745167, 439.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
824.8758508390492, 515.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.8485198511377, 639.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
81.0, 756.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
83.0, 316.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
81.0, 440.0

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
79.0, 512.0

c57

c57

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
780.0, 747.009319187599

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.0, 741.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.3715705307979, 453.83767392153175

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
80.0, 576.2123145706574

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
815.0, 872.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
768.0, 750.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.0, 737.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.0, 886.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.0, 804.0

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
664.0, 364.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
345.76256170793187, 513.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
276.0, 316.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back