1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18472258.csml convertedTime:2009.07.01.11:19

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Developmental plasticity of lymphocytes.
Authors Cobaleda C, Busslinger M.
Affiliation Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
Abstract Experimental perturbation of signaling or transcription factor networks has beenused to study the developmental potential of lymphoid progenitors,lineage-committed precursors and mature lymphocytes. Common lymphoid progenitorsand uncommitted pro-T cells can be efficiently diverted into myeloid orerythroid lineages by ectopic cytokine signaling or retroviral expression of themyeloid C/EBPalpha or erythroid GATA1 transcription factor. Forced C/EBPalphaexpression furthermore induces direct transdifferentiation of immaturethymocytes or B cells into macrophages. Notably, conditional inactivation of theB cell commitment factor Pax5 is sufficient to convert mature B cells intofunctional T cells via dedifferentiation to uncommitted progenitors. Togetherthese experiments have uncovered an unanticipated developmental plasticity oflymphocytes, which may account for lineage switches observed in humanmalignancies.
PMID 18472258
Model Abstract

Entity

G010325:C/EBPalpha G010392:CD19 G010693:Tlr4 G010962:TLR2 G011496:PAX5 G011500:GATA1 G011501:GATA3 G011631:GATA2 G011746:TCF7 G011894:CD79A G026871:BLNK MO000016830:IL-7 MO000016840:IL-7R MO000016882:LPS MO000017046:SCF MO000017690:BCR MO000019394:TLR4 MO000019397:TLR2 MO000019417:C/EBPalpha MO000030955:Notch1 MO000032474:GATA-2 MO000032476:GATA-1 MO000032503:E2A MO000034634:GATA-3 MO000037161:Pax-5 MO000090399:FLT3L MO000092644:EBF1 MO000118017:Blimp-1 e1:CMPs e10: e100: e101: e102:IL-7:IL-7R e103:Macrophage e104:erythropoietin e105:SCF e106:Erythroblast e107:GATA1 e108:GATA-1 e109:megakaryocytes e11: e110:Erythrocytes e111: e112: e113: e114: e115: e116: e117: e118: e119: e12: e120: e121: e122: e123: e124: e125: e126: e127: e128: e129: e13: e130: e131: e132:IL-2:IL-2R e133: e134: e135: e136: e137: e138: e139: e14: e140: e141: e142: e143: e144: e145: e146: e147: e148: e149:IL-2:IL-2R e15: e150:GM-CSF:GM-CSFR e151:C/EBPalpha e152:C/EBPalpha e153:C/EBPalpha e154:C/EBPalpha e155:C/EBPalpha e156: e157: e158: e159: e16:B-lymphoid genes e160: e161: e162: e163: e164: e165: e166: e167: e168: e169:GATA3 e17:B-lineage inappropriate genes e170:Myeloid e171:GATA3 e172:GATA3 e173:GATA-3 e174:GATA-3 e175:Mast cells e176: e177: e178: e179: e18:IL-7:IL-7R e180: e181: e182: e183: e184: e185: e186: e187: e188: e189: e19:B-cell specific genes e190: e191: e192: e193: e194: e195:Pax-5 e196: e197:Foreign antigens e198:BCR{active} e199:Plasma cells e2:LLMPs e20:Blimp1 e21:HSCs e22: e23: e24: e25: e26: e27: e28: e29: e3:Erythroid cells e30: e31: e32: e33: e34: e35: e36: e37: e38: e39: e4:Megakaryocytes e40: e41: e42: e43: e44: e45: e46: e47: e48: e49: e5:Multipotent progenitors e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:Myeloid cells e60: e61: e62: e63: e64: e65:Delta-like 4 e66:Delta-like 4:Notch1 e67:Granulocyte e68:Monocyte e69:IL-2:IL-2R e7:ELPs e70:C/EBPalpha e71: e72:GM-CSF:GM-CSFR e73:DC e74:Pam3CSK4 e75:TLR2:Pam3CSK4 e76:LPS:TLR4 e77: e78: e79: e8: e80: e81: e82: e83: e84: e85: e86: e87: e88: e89: e9: e90: e91: e92: e93: e94: e95: e96: e97: e98: e99:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p7 p8 p9
Model Detail
176.0, 1312.0
24.0, 24.0

C/EBPalpha

--

G010325

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m93306

10

false

infinite

0

unit false false false
TRANSFACG010325

--

Go back
692.0, 1920.0
24.0, 24.0

CD19

--

G010392

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p53

--

true true true true

csml-variable:Double

m93367

10

false

infinite

0

unit false false false
TRANSFACG010392

--

Go back
504.0, 728.0
24.0, 24.0

Tlr4

--

G010693

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m93614

10

false

infinite

0

unit false false false
TRANSFACG010693

--

Go back
462.0, 722.0
20.0, 20.0

TLR2

--

G010962

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m93848

10

false

infinite

0

unit false false false
TRANSFACG010962

--

Go back
710.0, 1766.0
27.0, 27.0

PAX5

--

G011496

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p56

p57

true true true true

csml-variable:Double

m94373

10

false

infinite

0

unit false false false
TRANSFACG011496

--

Go back
213.0, 1365.0
22.0, 22.0

GATA1

--

G011500

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m94377

10

false

infinite

0

unit false false false
TRANSFACG011500

--

Go back
863.0, 383.0
25.0, 25.0

GATA3

--

G011501

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p18

--

true true true true

csml-variable:Double

m94378

10

false

infinite

0

unit false false false
TRANSFACG011501

--

Go back
229.0, 1417.0
22.0, 22.0

GATA2

--

G011631

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m94470

10

false

infinite

0

unit false false false
TRANSFACG011631

--

Go back
920.0, 340.0
24.0, 24.0

TCF7

--

G011746

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p19

--

true true true true

csml-variable:Double

m94568

10

false

infinite

0

unit false false false
TRANSFACG011746

--

Go back
639.0, 1871.0
25.0, 25.0

CD79A

--

G011894

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p52

--

true true true true

csml-variable:Double

m94708

10

false

infinite

0

unit false false false
TRANSFACG011894

--

Go back
750.0, 1934.0
28.0, 28.0

BLNK

--

G026871

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p54

--

true true true true

csml-variable:Double

m105574

10

false

infinite

0

unit false false false
TRANSFACG026871

--

Go back
222.0, 550.0
20.0, 20.0

IL-7

--

MO000016830

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11 p29 p30 p39

true true true true

csml-variable:Double

m1767

10

false

infinite

0

unit false false false
InterProIPR001181
TRANSPATHMO000016830

--

Go back
347.0, 551.0
18.0, 18.0

IL-7R

--

MO000016840

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m1776

10

false

infinite

0

unit false false false
TRANSPATHMO000016840

--

Go back
400.0, 968.0
16.0, 16.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
262.0, 818.0
20.0, 20.0

SCF

--

MO000017046

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30

true true true true

csml-variable:Double

m1943

10

false

infinite

0

unit false false false
InterProIPR003452
TRANSPATHMO000017046

--

Go back
830.0, 1558.0
20.0, 20.0

BCR

--

MO000017690

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p55

true true true true

csml-variable:Double

m2450

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
501.0, 869.0
22.0, 22.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

p26

p28

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
343.0, 723.0
18.0, 18.0

TLR2

--

MO000019397

cso30:c:Protein

cso30:i:CC_CellComponent

--

p25

p27

true true true true

csml-variable:Double

m3964

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019397

--

Go back
305.0, 1245.0
22.0, 22.0

C/EBPalpha

--

MO000019417

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p34

true true true true

csml-variable:Double

m3982

10

false

infinite

0

unit false false false
InterProIPR000217
TRANSPATHMO000019417

--

Go back
747.0, 35.0
17.0, 17.0

Notch1

--

MO000030955

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m10514

10

false

infinite

0

unit false false false
TRANSPATHMO000030955

--

Go back
317.0, 1449.0
22.0, 22.0

GATA-2

--

MO000032474

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

p36

true true true true

csml-variable:Double

m11425

10

false

infinite

0

unit false false false
InterProIPR001179
TRANSPATHMO000032474

--

Go back
313.0, 1289.0
22.0, 22.0

GATA-1

--

MO000032476

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p35 p37

true true true true

csml-variable:Double

m11427

10

false

infinite

0

unit false false false
InterProIPR000679
TRANSPATHMO000032476

--

Go back
494.0, 474.0
20.0, 20.0

E2A

--

MO000032503

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m11454

10

false

infinite

0

unit false false false
InterProIPR001092
TRANSPATHMO000032503

--

Go back
143.0, 1171.0
18.0, 18.0

GATA-3

--

MO000034634

cso30:c:Protein

cso30:i:CC_CellComponent

--

p46

p47

true true true true

csml-variable:Double

m13174

10

false

infinite

0

unit false false false
InterProIPR000679
TRANSPATHMO000034634

--

Go back
597.0, 505.0
21.0, 21.0

Pax-5

--

MO000037161

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8 p9

true true true true

csml-variable:Double

m15456

10

false

infinite

0

unit false false false
InterProIPR001523
TRANSPATHMO000037161

--

Go back
280.0, 892.0
16.0, 16.0

FLT3L

--

MO000090399

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29 p30

true true true true

csml-variable:Double

m63933

10

false

infinite

0

unit false false false
TRANSPATHMO000090399

--

Go back
537.0, 505.0
21.0, 21.0

EBF1

--

MO000092644

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7

true true true true

csml-variable:Double

m362249

10

false

infinite

0

unit false false false
Affymetrix115110_at
EnsemblENSMUSG00000057098
InterProIPR001092
MGD9830166E18Rik
ProteomeHumanPSD/Ebf1
RGDEbf1
RefSeqNM_007897
TRANSFACT09926
TRANSPATHMO000092644
UnigeneMm.339905
UniProtQ07802

--

Go back
886.0, 1918.0
20.0, 20.0

Blimp-1

--

MO000118017

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59

p60

true true true true

csml-variable:Double

m87014

10

false

infinite

0

unit false false false
TRANSPATHMO000118017

--

Go back
139.5, 190.0
41.0, 60.0

CMPs

--

e1

cso30:c:Cell

cso30:i:CC_CellComponent

--

p1

p2 p3

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false false false

--

Go back
339.6298360183223, 388.45921478934685
351.92474569448956, 510.99473074839983

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
11.559051469543135, 1047.5262402570738
381.38408880155094, 549.0136947962546

--

e100

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false true false

--

Go back
5.900470721129125, 1043.1354391480081
387.9510891610431, 545.7380965894232

--

e101

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false true false

--

Go back
383.5, 1144.0
17.019074764306072, 32.940144705108544

IL-7:IL-7R

--

e102

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p34 p35 p36

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
699.5, 1202.0
41.0, 60.0

Macrophage

--

e103

cso30:c:Cell

cso30:i:CC_Extracellular

--

p21 p22 p34 p35 p36

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
438.0, 1425.0
12.84190832553789, 29.635173058933596

erythropoietin

--

e104

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p37

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
433.0, 1095.5
21.44000000000001, 16.080000000000002

SCF

--

e105

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p37 p39

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
599.5, 1334.0
34.99867449346714, 51.21757242946411

Erythroblast

--

e106

cso30:c:Cell

cso30:i:CC_Extracellular

--

p37

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
533.0, 673.0
22.0, 22.0

GATA1

--

e107

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p38

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
TRANSFACG011500

--

Go back
597.0, 813.0
22.0, 22.0

GATA-1

--

e108

cso30:c:Protein

cso30:i:CC_CellComponent

--

p38

p39

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
InterProIPR000679
TRANSPATHMO000032476

--

Go back
606.5, 1102.0
35.95360727135012, 52.61503503124408

megakaryocytes

--

e109

cso30:c:Cell

cso30:i:CC_Extracellular

--

p39

--

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
346.6683309322119, 395.49770970323664
337.84775586671003, 496.9177409206201

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
700.5, 1101.0
31.582654800227225, 46.21851921984473

Erythrocytes

--

e110

cso30:c:Cell

cso30:i:CC_Extracellular

--

p39

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
795.824273257896, 907.3129095487233
301.0522492814995, 437.12786595673714

--

e111

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false true false

--

Go back
812.9842514669413, 923.870783259206
266.73229286340836, 404.0121185357721

--

e112

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false true false

--

Go back
795.824273257896, 907.3129095487233
301.0522492814995, 437.12786595673714

--

e113

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false true false

--

Go back
801.845318243526, 913.3339545343532
289.0101593102391, 425.08577598547697

--

e114

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false true false

--

Go back
865.8590460363246, 1141.084678633492
179.92660366888532, 163.17366105539534

--

e115

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false true false

--

Go back
885.2924594679736, 1144.9516571833149
105.20847961271889, 158.14777827134822

--

e116

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false true false

--

Go back
1118.9709215617934, 565.9933717671775
368.2883345661928, 534.7546617901119

--

e117

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false true false

--

Go back
868.539516854483, 1143.5976200255157
174.5656620325685, 158.14777827134822

--

e118

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false true false

--

Go back
865.8590460363246, 1141.084678633492
179.92660366888532, 163.17366105539534

--

e119

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false true false

--

Go back
718.7525758999825, 28.790555860102245
367.1753460565738, 533.1386024741442

--

e12

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false true false

--

Go back
967.7169371263451, 1255.0046884052265
31.83059096563149, 28.81506129520332

--

e120

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false true false

--

Go back
868.2044580022134, 1143.262561173246
175.2357797371081, 158.81789597588778

--

e121

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false true false

--

Go back
865.8590460363246, 1141.084678633492
179.92660366888532, 163.17366105539534

--

e122

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false true false

--

Go back
865.8590460363246, 1141.084678633492
179.92660366888532, 163.17366105539534

--

e123

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false true false

--

Go back
908.266734143766, 1213.5977052914484
5.698011163820412, 2.7434868566542763

--

e124

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false true false

--

Go back
908.0764614223201, 1205.4159782692946
19.50295394815752, 35.105317106683565

--

e125

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false true false

--

Go back
916.2581884444743, 1228.2487048427472
3.0443635431270226, 3.044363543127026

--

e126

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false true false

--

Go back
997.2021161260881, 1208.096449087453
11.2408255897751, 10.175905270743797

--

e127

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false true false

--

Go back
1126.3366882531168, 573.3591384585013
353.55680118354485, 520.0231284074638

--

e128

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false true false

--

Go back
800.1712591544878, 917.6764902046554
287.97655326027444, 408.0553374610527

--

e129

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false true false

--

Go back
343.5483422979849, 392.7446633483866
342.8526881505268, 493.54660201960615

--

e13

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false true false

--

Go back
1139.9633566320667, 586.2492301683178
326.3034644256468, 494.2429449878304

--

e130

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false true false

--

Go back
1221.5608726679784, 817.6902006951248
117.11098418810377, 176.03944119995228

--

e131

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false true false

--

Go back
978.5, 906.0
18.188116641087486, 35.202806402104805

IL-2:IL-2R

--

e132

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p21

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
1200.9126267781521, 818.1829778480613
194.31472217198106, 176.03944119995228

--

e133

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false true false

--

Go back
1313.3102424459184, 940.1938130153998
35.43166719066832, 32.0749829304998

--

e134

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false true false

--

Go back
1202.5396618603565, 815.810012930265
195.06065200757422, 176.78537103554515

--

e135

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false true false

--

Go back
1199.9289074357805, 813.3857409645874
200.28216085672526, 181.6339149669

--

e136

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false true false

--

Go back
1199.9289074357805, 813.3857409645874
200.28216085672526, 181.6339149669

--

e137

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false true false

--

Go back
1256.0298338191076, 910.4108565516548
3.388780182684888, 3.3887801826848873

--

e138

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false true false

--

Go back
1247.1342858395592, 894.1023519224831
6.342641750609811, 3.0538645465899097

--

e139

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false true false

--

Go back
726.0960828211132, 36.13406278123375
352.4883322143107, 518.451588631882

--

e14

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false true false

--

Go back
1246.922487078141, 884.9950051815173
21.70937304532508, 39.07687148158516

--

e140

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false true false

--

Go back
1199.9289074357805, 813.3857409645874
200.28216085672526, 181.6339149669

--

e141

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false true false

--

Go back
1202.9126267781521, 816.1829778480613
194.31472217198106, 176.03944119995228

--

e142

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false true false

--

Go back
1199.9289074357805, 813.3857409645874
200.28216085672526, 181.6339149669

--

e143

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false true false

--

Go back
1346.131155212012, 887.9787245238891
12.512528959179443, 11.327131478836137

--

e144

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false true false

--

Go back
1123.8096930987995, 568.1452668002892
361.17611646840606, 511.7772277633499

--

e145

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false true false

--

Go back
1122.519354022264, 574.1668491574524
356.98417583528357, 502.17635695828517

--

e146

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false true false

--

Go back
1125.1000321753347, 577.1776403360334
346.48055221980877, 503.08976182316235

--

e147

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false true false

--

Go back
1128.5409363794265, 586.2100138717788
344.89867844242616, 496.49186565973946

--

e148

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false true false

--

Go back
1182.5, 558.0
18.188116641087486, 35.202806402104805

IL-2:IL-2R

--

e149

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p22

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
718.7525758999825, 28.790555860102245
367.1753460565738, 533.1386024741442

--

e15

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false true false

--

Go back
1123.5, 788.0
17.012278009208494, 32.92698969524227

GM-CSF:GM-CSFR

--

e150

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p24

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
445.0, 493.0
22.0, 22.0

C/EBPalpha

--

e151

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p41

true true true true

csml-variable:Double

m151

10

false

infinite

0

unit false false false
InterProIPR000217
TRANSPATHMO000019417

--

Go back
904.0, 1184.0
24.0, 24.0

C/EBPalpha

--

e152

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m152

10

false

infinite

0

unit false false false
TRANSFACG010325

--

Go back
1220.0, 888.0
24.0, 24.0

C/EBPalpha

--

e153

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p44

true true true true

csml-variable:Double

m153

10

false

infinite

0

unit false false false
TRANSFACG010325

--

Go back
885.0, 1025.0
22.0, 22.0

C/EBPalpha

--

e154

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p43

true true true true

csml-variable:Double

m154

10

false

infinite

0

unit false false false
InterProIPR000217
TRANSPATHMO000019417

--

Go back
1205.0, 713.0
22.0, 22.0

C/EBPalpha

--

e155

cso30:c:Protein

cso30:i:CC_CellComponent

--

p44

p45

true true true true

csml-variable:Double

m155

10

false

infinite

0

unit false false false
InterProIPR000217
TRANSPATHMO000019417

--

Go back
807.7283297939218, 273.1108544836899
201.19867775549818, 182.4650950966998

--

e156

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false true false

--

Go back
807.7283297939218, 273.1108544836899
201.19867775549818, 182.4650950966998

--

e157

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false true false

--

Go back
810.7257030193293, 275.92089188250964
195.20393130468256, 176.84502029906017

--

e158

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false true false

--

Go back
807.7283297939218, 273.1108544836899
201.19867775549818, 182.4650950966998

--

e159

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m159

0

false

infinite

0

unit false true false

--

Go back
462.0, 658.0
35.86505190311418, 19.1280276816609

B-lymphoid genes

--

e16

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p7

--

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
921.6285123594179, 400.4992165635215
35.59380705171756, 32.221762173133826

--

e160

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m160

0

false

infinite

0

unit false true false

--

Go back
810.7257030193293, 275.92089188250964
195.20393130468256, 176.84502029906017

--

e161

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false true false

--

Go back
954.599617838904, 348.0451851188849
12.569787899208933, 11.37896588770495

--

e162

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false true false

--

Go back
807.7283297939218, 273.1108544836899
201.19867775549818, 182.4650950966998

--

e163

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m163

0

false

infinite

0

unit false true false

--

Go back
829.4592856781284, 277.43501197495743
117.64689909725598, 176.84502029906017

--

e164

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m164

0

false

infinite

0

unit false true false

--

Go back
810.3510313661534, 275.54622022933376
195.95327461103463, 177.59436360541196

--

e165

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false true false

--

Go back
855.1497260738548, 354.1968350231703
6.371666494113826, 3.067839423091848

--

e166

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m166

0

false

infinite

0

unit false true false

--

Go back
854.9369580940946, 345.0478118934771
21.808717925431708, 39.25569226577711

--

e167

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m167

0

false

infinite

0

unit false true false

--

Go back
864.0859812237884, 370.57996946471434
3.404287676164945, 3.4042876761649508

--

e168

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m168

0

false

infinite

0

unit false true false

--

Go back
117.0, 1349.0
22.0, 22.0

GATA3

--

e169

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m169

10

false

infinite

0

unit false false false
TRANSFACG011501

--

Go back
541.0, 634.0
38.04498269896193, 20.29065743944637

B-lineage inappropriate genes

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p8

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
143.5, 878.0
41.0, 60.0

Myeloid

--

e170

cso30:c:Cell

cso30:i:CC_Extracellular

--

p47

--

true true true true

csml-variable:Double

m170

0

false

infinite

0

unit false false false

--

Go back
969.0, 1193.0
22.0, 22.0

GATA3

--

e171

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
TRANSFACG011501

--

Go back
1301.0, 901.0
22.0, 22.0

GATA3

--

e172

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p49

true true true true

csml-variable:Double

m172

10

false

infinite

0

unit false false false
TRANSFACG011501

--

Go back
967.0, 1035.0
18.0, 18.0

GATA-3

--

e173

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p50

true true true true

csml-variable:Double

m173

10

false

infinite

0

unit false false false
InterProIPR000679
TRANSPATHMO000034634

--

Go back
1171.0, 1023.0
18.0, 18.0

GATA-3

--

e174

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49

p51

true true true true

csml-variable:Double

m174

10

false

infinite

0

unit false false false
InterProIPR000679
TRANSPATHMO000034634

--

Go back
1207.5, 1238.0
41.0, 60.0

Mast cells

--

e175

cso30:c:Cell

cso30:i:CC_Extracellular

--

p50 p51

--

true true true true

csml-variable:Double

m175

0

false

infinite

0

unit false false false

--

Go back
547.5150739581406, 1462.9362958870934
426.1433798924708, 618.7601876038673

--

e176

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m176

0

false

infinite

0

unit false true false

--

Go back
547.5150739581406, 1462.9362958870934
426.1433798924708, 618.7601876038673

--

e177

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m177

0

false

infinite

0

unit false true false

--

Go back
556.0379415559902, 1471.4591634849423
409.097644696772, 601.7144524081691

--

e178

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m178

0

false

infinite

0

unit false true false

--

Go back
571.8052466120115, 1486.3741817811792
377.56303458472917, 571.8844158156951

--

e179

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m179

0

false

infinite

0

unit false true false

--

Go back
346.5, 469.0
19.45910984433238, 37.662793247094946

IL-7:IL-7R

--

e18

cso30:c:Complex

cso30:i:CC_Extracellular

--

p11

p12

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
754.0330072397746, 1921.0976159707134
46.37307238055758, 48.85103522336538

--

e180

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m180

0

false

infinite

0

unit false true false

--

Go back
609.5442764540377, 1732.2258809501432
254.31969168705788, 268.1126584352146

--

e181

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m181

0

false

infinite

0

unit false true false

--

Go back
605.6391756219901, 1727.965616250431
262.12989335115185, 276.63318783463876

--

e182

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m182

0

false

infinite

0

unit false true false

--

Go back
679.0642364804155, 1875.7373968111567
4.435245675790088, 5.1612005664129725

--

e183

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m183

0

false

infinite

0

unit false true false

--

Go back
667.1445137267297, 1837.0283925630602
28.413292610530284, 59.515094031449614

--

e184

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m184

0

false

infinite

0

unit false true false

--

Go back
667.4217165814664, 1850.899119085295
8.301268563011327, 4.651115321124375

--

e185

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m185

0

false

infinite

0

unit false true false

--

Go back
633.9511566543305, 1734.5214206407145
153.27520765784305, 268.1126584352146

--

e186

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m186

0

false

infinite

0

unit false true false

--

Go back
605.6391756219901, 1727.965616250431
262.12989335115185, 276.63318783463876

--

e187

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m187

0

false

infinite

0

unit false true false

--

Go back
796.9891163922907, 1841.5726749094183
16.376435462813063, 17.251516549558225

--

e188

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m188

0

false

infinite

0

unit false true false

--

Go back
609.5442764540377, 1732.2258809501432
254.31969168705788, 268.1126584352146

--

e189

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m189

0

false

infinite

0

unit false true false

--

Go back
555.0, 709.0
42.14532871972318, 22.477508650519027

B-cell specific genes

--

e19

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p9

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
605.6391756219901, 1727.965616250431
262.12989335115185, 276.63318783463876

--

e190

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m190

0

false

infinite

0

unit false true false

--

Go back
609.0561388500315, 1731.6578456568493
255.29596689506977, 269.2487290218042

--

e191

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m191

0

false

infinite

0

unit false true false

--

Go back
605.6391756219901, 1727.965616250431
262.12989335115185, 276.63318783463876

--

e192

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m192

0

false

infinite

0

unit false true false

--

Go back
582.8898072919609, 1472.5854403159617
362.62128932225147, 607.4449978972951

--

e193

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m193

0

false

infinite

0

unit false true false

--

Go back
602.2663092664137, 1501.4693792231853
315.3387374220053, 532.8156786492561

--

e194

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m194

0

false

infinite

0

unit false true false

--

Go back
857.0, 1721.0
21.0, 21.0

Pax-5

--

e195

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

p52 p53 p54

true true true true

csml-variable:Double

m195

10

false

infinite

0

unit false false false
InterProIPR001523
TRANSPATHMO000037161

--

Go back
601.0919463977508, 1491.9033124882535
328.7134583007594, 542.0164583349502

--

e196

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m196

0

false

infinite

0

unit false true false

--

Go back
1027.0, 1587.5
25.694200351493848, 16.701230228470997

Foreign antigens

--

e197

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p55

true true true true

csml-variable:Double

m197

0

false

infinite

0

unit false false false

--

Go back
770.0, 1654.0
20.0, 20.0

BCR{active}

--

e198

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55

p56 p58

true true true true

csml-variable:Double

m198

10

false

infinite

0

unit false false false
TRANSPATHMO000017690

--

Go back
1106.5, 1894.0
35.65858738875213, 52.18329861768604

Plasma cells

--

e199

cso30:c:Cell

cso30:i:CC_Extracellular

--

p60

--

true true true true

csml-variable:Double

m199

0

false

infinite

0

unit false false false

--

Go back
243.5, 188.0
32.8869532285552, 48.127248627153946

LLMPs

--

e2

cso30:c:Cell

cso30:i:CC_CellComponent

--

p1 p15

p4 p5 p16

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false false false

--

Go back
655.0, 1814.0
50.70934256055364, 27.04498269896194

Blimp1

--

e20

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

p58

p59

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
168.5, 24.0
38.46903995455406, 56.29615603105474

HSCs

--

e21

cso30:c:Cell

cso30:i:CC_Extracellular

--

--

p13 p15

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
743.6815706252069, 52.985199893213775
325.31735660612435, 492.74931440792136

--

e22

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false true false

--

Go back
722.7525758999825, 32.79055586010226
367.1753460565738, 533.1386024741442

--

e23

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false true false

--

Go back
739.6815706252069, 48.985199893213746
325.31735660612435, 492.74931440792136

--

e24

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false true false

--

Go back
860.0859812237884, 366.57996946471434
3.404287676164945, 3.4042876761649508

--

e25

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false true false

--

Go back
850.9369580940946, 341.0478118934771
21.808717925431708, 39.25569226577711

--

e26

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false true false

--

Go back
851.1497260738548, 350.1968350231703
6.371666494113826, 3.067839423091848

--

e27

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false true false

--

Go back
803.7283297939218, 269.1108544836899
201.19867775549818, 182.4650950966998

--

e28

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false true false

--

Go back
803.7283297939218, 269.1108544836899
201.19867775549818, 182.4650950966998

--

e29

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false true false

--

Go back
70.5, 286.0
35.27040333270213, 51.61522438932022

Erythroid cells

--

e3

cso30:c:Cell

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false false false

--

Go back
917.6285123594179, 396.4992165635215
35.59380705171756, 32.221762173133826

--

e30

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false true false

--

Go back
803.7283297939218, 269.1108544836899
201.19867775549818, 182.4650950966998

--

e31

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false true false

--

Go back
803.7283297939218, 269.1108544836899
201.19867775549818, 182.4650950966998

--

e32

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false true false

--

Go back
806.7257030193293, 271.92089188250964
195.20393130468256, 176.84502029906017

--

e33

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false true false

--

Go back
806.7257030193293, 271.92089188250964
195.20393130468256, 176.84502029906017

--

e34

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false true false

--

Go back
825.4592856781284, 273.43501197495743
117.64689909725598, 176.84502029906017

--

e35

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false true false

--

Go back
950.599617838904, 344.0451851188849
12.569787899208933, 11.37896588770495

--

e36

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false true false

--

Go back
806.3510313661534, 271.54622022933376
195.95327461103463, 177.59436360541196

--

e37

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false true false

--

Go back
745.9044427000829, 47.95359440273302
326.9240576203513, 470.61686646641033

--

e38

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false true false

--

Go back
742.6428634752352, 39.391948937509
328.42349100838493, 476.87090894417486

--

e39

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false true false

--

Go back
144.5, 369.0
31.986366218519223, 46.80931641734522

Megakaryocytes

--

e4

cso30:c:Cell

cso30:i:CC_CellComponent

--

p2

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false false false

--

Go back
719.8562649338693, 38.53806711576767
360.7201255132743, 507.4317876638152

--

e40

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false true false

--

Go back
741.4197712659181, 30.83030347228498
342.35318628836825, 485.10562189938537

--

e41

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false true false

--

Go back
730.0960828211132, 40.13406278123375
352.4883322143107, 518.451588631882

--

e42

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false true false

--

Go back
722.7525758999825, 32.79055586010226
367.1753460565738, 533.1386024741442

--

e43

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false true false

--

Go back
743.6815706252069, 52.985199893213775
325.31735660612435, 492.74931440792136

--

e44

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false true false

--

Go back
722.7525758999825, 32.79055586010226
367.1753460565738, 533.1386024741442

--

e45

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false true false

--

Go back
730.0960828211132, 40.13406278123375
352.4883322143107, 518.451588631882

--

e46

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false true false

--

Go back
722.7525758999825, 32.79055586010226
367.1753460565738, 533.1386024741442

--

e47

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false true false

--

Go back
527.5647227207078, 12.131833720423884
183.9111554197745, 267.0389976695122

--

e48

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false true false

--

Go back
527.5647227207078, 12.131833720423884
183.9111554197745, 267.0389976695122

--

e49

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false true false

--

Go back
68.5, 88.0
38.46903995455406, 56.29615603105474

Multipotent progenitors

--

e5

cso30:c:Cell

cso30:i:CC_Extracellular

--

p13

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
398.27908813168926, 541.5318297841532
244.19668764416252, 221.459565889585

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
424.6541493669984, 546.7800995441684
142.78912461874674, 214.63842936321203

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
401.46228517733, 544.487655612249
237.8302935528808, 215.54791423339492

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
401.9170276124211, 544.9423980473399
236.9208086826975, 214.63842936321203

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
398.27908813168926, 541.5318297841532
244.19668764416252, 221.459565889585

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
398.27908813168926, 541.5318297841532
244.19668764416252, 221.459565889585

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
403.43695190684184, 544.9423980473399
236.9208086826975, 214.63842936321203

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
576.5381226875772, 632.480316802465
15.256067304312174, 13.810755664956327

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
536.5207883995201, 696.1442577152785
43.200531333697285, 39.10784941787337

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
398.27908813168926, 541.5318297841532
244.19668764416252, 221.459565889585

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
238.5, 334.0
35.138420753645136, 51.42207915167582

Myeloid cells

--

e6

cso30:c:Cell

cso30:i:CC_CellComponent

--

p3 p4

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
455.83487340923114, 639.9466309300283
7.733350288348848, 3.723464953649454

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
455.576634953225, 628.8423773217312
26.46944174070626, 47.644995133271294

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
466.6808885615214, 659.8309920425594
4.131815296110241, 4.131815296110248

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
531.2429458291033, 15.810056828819228
176.55470920298356, 259.6825514527213

--

e63

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false true false

--

Go back
538.047658579635, 22.246947268511462
162.94528370192026, 246.8087705733372

--

e64

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false true false

--

Go back
685.0, 136.5
22.49560632688928, 14.622144112478033

Delta-like 4

--

e65

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
727.5, 167.0
17.229774172330625, 33.347950010962506

Delta-like 4:Notch1

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p14

p18 p19

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
875.5, 595.0
33.67108502177617, 49.274758568452945

Granulocyte

--

e67

cso30:c:Cell

cso30:i:CC_Extracellular

--

p20 p21 p22 p23 p24 p41 p43 p45

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
747.5, 719.0
33.67108502177617, 49.274758568452945

Monocyte

--

e68

cso30:c:Cell

cso30:i:CC_Extracellular

--

p20 p23 p24 p41 p43 p45

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
666.5, 638.0
18.188116641087486, 35.202806402104805

IL-2:IL-2R

--

e69

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
419.5, 276.0
32.747206968377206, 47.922741904942264

ELPs

--

e7

cso30:c:Cell

cso30:i:CC_CellComponent

--

p5

p6 p17

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false false false

--

Go back
436.0, 592.0
24.0, 24.0

C/EBPalpha

--

e70

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSFACG010325

--

Go back
1118.9709215617934, 565.9933717671775
368.2883345661928, 534.7546617901119

--

e71

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false true false

--

Go back
667.5, 776.0
17.012278009208494, 32.92698969524227

GM-CSF:GM-CSFR

--

e72

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p23

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
728.5, 965.0
31.039197121757237, 45.42321530013255

DC

--

e73

cso30:c:Cell

cso30:i:CC_Extracellular

--

p23 p24 p29 p30

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
267.0, 666.0
34.617325483599664, 19.616484440706476

Pam3CSK4

--

e74

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p27

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
343.5, 768.0
17.03946502959877, 32.97960973470731

TLR2:Pam3CSK4

--

e75

cso30:c:Complex

cso30:i:CC_Extracellular

--

p27

p30

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
584.5, 869.0
15.754878316158734, 30.493312869984642

LPS:TLR4

--

e76

cso30:c:Complex

cso30:i:CC_Extracellular

--

p28

p29

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
0.9766642086708544, 1025.1709628680433
407.24804029138966, 591.324154503097

--

e77

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false true false

--

Go back
532.3436752894029, 22.22736393194893
172.2311257287443, 247.93180804262178

--

e78

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false true false

--

Go back
530.6254002085236, 17.716891844641367
173.0210617837906, 251.22658171006384

--

e79

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false true false

--

Go back
359.68954652290887, 407.81507580254396
311.805324685318, 472.28300872200515

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
529.9810470531941, 13.206419757333805
180.35954619082042, 255.56481821872705

--

e80

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false true false

--

Go back
531.3366938978645, 18.213401148872123
178.26622806767978, 250.7704571785512

--

e81

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false true false

--

Go back
0.9766642086708544, 1025.1709628680433
407.24804029138966, 591.324154503097

--

e82

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false true false

--

Go back
24.189802505280056, 1047.5696050840697
360.8217636981712, 546.5268700710442

--

e83

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false true false

--

Go back
9.121625014498647, 1033.315923673871
390.95811867973424, 575.0342328914413

--

e84

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false true false

--

Go back
77.18150425510214, 1279.186890359744
221.4691855779281, 200.84821857812108

--

e85

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false true false

--

Go back
80.48085897507127, 1282.2800354097149
214.87047613798984, 194.6619284781789

--

e86

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false true false

--

Go back
77.18150425510214, 1279.186890359744
221.4691855779281, 200.84821857812108

--

e87

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false true false

--

Go back
202.55698361392922, 1419.4094659584323
39.17983729963349, 35.46806323966822

--

e88

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false true false

--

Go back
80.06843963507521, 1281.8676160697191
215.69531481798225, 195.486767158171

--

e89

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false true false

--

Go back
339.6298360183223, 388.45921478934685
351.92474569448956, 510.99473074839983

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
238.84988553358983, 1361.6707583589716
13.836177851566552, 12.525382055102355

--

e90

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false true false

--

Go back
80.48085897507127, 1282.2800354097149
214.87047613798984, 194.6619284781789

--

e91

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false true false

--

Go back
77.18150425510214, 1279.186890359744
221.4691855779281, 200.84821857812108

--

e92

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false true false

--

Go back
101.10182597487824, 1283.9467011526633
129.4996727587885, 194.6619284781789

--

e93

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false true false

--

Go back
129.3805451744849, 1368.4421790733677
7.013603692467598, 3.3769202963732914

--

e94

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false true false

--

Go back
129.14634109461588, 1358.371403639003
24.005918186567847, 43.21065273582214

--

e95

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false true false

--

Go back
139.2171165289812, 1386.4758932232771
3.747265277903273, 3.747265277903273

--

e96

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false true false

--

Go back
77.18150425510214, 1279.186890359744
221.4691855779281, 200.84821857812108

--

e97

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false true false

--

Go back
7.754148184735129, 1037.5383691344525
383.1333024892076, 556.3095552143292

--

e98

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false true false

--

Go back
6.327309452932127, 1027.5504980118312
399.3834499402988, 565.9160323877295

--

e99

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false true false

--

Go back
185.0, 105.0
21.0, 21.0

p1

p1

cso30:i:CE_CellDifferentiation

cso30:i:CC_CellComponent

--

e5

e1 e2

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m5*0.1

nodelay

--

true

0

false

PMID: 18472258 Hematopoietic stem cells (HSCs) in the bone marrow give rise to all blood cell types by differentiating via multipotent progenitors into common myeloid progenitors (CMPs) or lymphoid-primed multipotent progenitors (LMPPs).

Go back
310.5, 693.0
1.5, 1.5

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

--

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0

1.0*0.1

nodelay

--

true

0

false

--

Go back
283.0, 551.0
17.0, 17.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016830 MO000016840

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c22 : 1
stoichiometry:c23 : 1

m1767*m1776*0.1

nodelay

--

true

0

false

PMID: 18472258,12208884,17440452,17582344 Entry of CLPs into the B cell lineage critically depends on signaling of the IL-7 receptor and expression of the three transcription factors E2A, EBF1, and Pax5

Go back
672.0, 1416.0
23.0, 23.0

p12

p12

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e18

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c24 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18472258,12208884,17440452,17582344 Entry of CLPs into the B cell lineage critically depends on signaling of the IL-7 receptor and expression of the three transcription factors E2A, EBF1, and Pax5

Go back
105.0, 41.0
21.0, 21.0

p1

p13

cso30:i:CE_CellDifferentiation

cso30:i:CC_CellComponent

--

e21

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18472258 Hematopoietic stem cells (HSCs) in the bone marrow give rise to all blood cell types by differentiating via multipotent progenitors into common myeloid progenitors (CMPs) or lymphoid-primed multipotent progenitors (LMPPs). ) PMID: 18472258, 17582341 T cells are also derived from HSCs in the bone marrow and yet develop in the thymus. Several hematopoietic progenitors (MPPs, LMPPs, ELPs, CLPs, and pre?pro-B cells) in the bone marrow have the potential to migrate to the thymus, where they promote T cell development

Go back
707.0, 91.0
17.0, 17.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e65 MO000030955

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c33 : 1

m65*m10514*0.1

nodelay

--

true

0

false

PMID: 18472258,17440450 Upon entry into the thymus, the TSPs experience a high density of the Notch ligand Delta-like 4, which is expressed on cortical epithelial cells

Go back
250.0, 90.0
19.0, 19.0

p14

p15

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e21

e2

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18472258,17582341 T cells are also derived from HSCs in the bone marrow and yet develop in the thymus. Several hematopoietic progenitors (MPPs, LMPPs, ELPs, CLPs, and pre?pro-B cells) in the bone marrow have the potential to migrate to the thymus, where they promote T cell development

Go back
686.0, 302.0
19.0, 19.0

p16

p16

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e2

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1

m2*0.1

nodelay

--

true

0

false

PMID: 18472258,17582341 Currently, the LMPPs and ELPs are considered to be the most probable candidates for the thymus-settling progenitor (TSP) that initiates T lymphopoiesis

Go back
678.0, 338.0
19.0, 19.0

p16

p17

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e7

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1

m7*0.1

nodelay

--

true

0

false

PMID: 18472258,17582341 Currently, the LMPPs and ELPs are considered to be the most probable candidates for the thymus-settling progenitor (TSP) that initiates T lymphopoiesis

Go back
849.0, 301.0
21.0, 21.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e66

G011501

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18472258,17440450,15356142 Signaling through the Notch1 receptor induces pro-T cell development by activating Gata3, Tcf7 (Tcf1) and the T cell gene expression program

Go back
905.0, 289.0
21.0, 21.0

p18

p19

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e66

G011746

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18472258,17440450,15356142 Signaling through the Notch1 receptor induces pro-T cell development by activating Gata3, Tcf7 (Tcf1) and the T cell gene expression program

Go back
150.0, 302.0
19.0, 19.0

p2

p2

cso30:i:CE_CellDifferentiation

cso30:i:CC_CellComponent

--

e1

e3 e4

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m1*0.1

nodelay

--

true

0

false

PMID: 18472258,15851035 Erythroid cells and megakaryocytes largely arise from CMPs, while myeloid cells can develop from either CMPs or LMPPs

Go back
802.0, 630.0
19.0, 19.0

p20

p20

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e69

e67 e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c41 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 18472258,11014194 Stimulation with human IL-2 efficiently redirects these transgenic CLPs to the granulocyte and monocyte (GM) lineages even under lymphoid differentiation conditions (IL-7 plus stromal OP9 cells), which normally allow wild-type CLPs to develop only into B lymphocytes

Go back
883.0, 823.0
17.0, 17.0

p21

p21

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e132

e67 e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c44 : 1

m132*0.1

nodelay

--

true

0

false

PMID: 18472258,11014194,11917122 Ectopic hIL-2R signaling also induces uncommitted DN1 and DN2 pro-T cells to differentiate into granulocytes and macrophages, which carry Dbeta1-Jbeta1 rearrangements at the TCRbeta locus as genetic evidence of their lineage conversion

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1054.0, 706.0
19.0, 19.0

p21

p22

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e149

e67 e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m149*0.1

nodelay

--

true

0

false

PMID: 18472258,11014194,11917122 Ectopic hIL-2R signaling also induces uncommitted DN1 and DN2 pro-T cells to differentiate into granulocytes and macrophages, which carry Dbeta1-Jbeta1 rearrangements at the TCRbeta locus as genetic evidence of their lineage conversion

Go back
733.0, 857.0
21.0, 21.0

p23

p23

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e72

e67 e68 e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c54 : 1

m72*0.1

nodelay

--

true

0

false

PMID: 18472258,11014194 Indeed, transgenic expression of a human GM-CSF receptor instructs CLPs and DN2 thymocytes to differentiate along the GM and DC lineages in response to hGM-CSF addition

Go back
973.0, 777.0
21.0, 21.0

p23

p24

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e150

e67 e68 e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c53 : 1
stoichiometry:c55 : 1

m150*0.1

nodelay

--

true

0

false

PMID: 18472258,11014194 Indeed, transgenic expression of a human GM-CSF receptor instructs CLPs and DN2 thymocytes to differentiate along the GM and DC lineages in response to hGM-CSF addition

Go back
378.0, 698.0
19.0, 19.0

p25

p25

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010962

MO000019397

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m93848*0.1

nodelay

--

true

0

false

PMID: 18472258,16782035 CLPs express high levels of the Toll-like receptor 2 (TLR2) and lower levels of TLR4.Indeed, the TLR2 ligand Pam3CSK4 or TLR4 ligand LPS efficiently redirects the developmental fate of wild-type CLPs toward DC differentiation under lymphoid culture conditions (SCF, Flt3L, and IL-7; Figure 2A), which normally promote B cell development

Go back
502.0, 802.0
19.0, 19.0

p25

p26

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010693

MO000019394

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m93614*0.1

nodelay

--

true

0

false

PMID: 18472258,16782035 CLPs express high levels of the Toll-like receptor 2 (TLR2) and lower levels of TLR4.Indeed, the TLR2 ligand Pam3CSK4 or TLR4 ligand LPS efficiently redirects the developmental fate of wild-type CLPs toward DC differentiation under lymphoid culture conditions (SCF, Flt3L, and IL-7; Figure 2A), which normally promote B cell development

Go back
277.0, 721.0
21.0, 21.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019397 e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m3964*m74*0.1

nodelay

--

true

0

false

PMID: 18472258,16782035 Indeed, the TLR2 ligand Pam3CSK4 or TLR4 ligand LPS efficiently redirects the developmental fate of wild-type CLPs toward DC differentiation under lymphoid culture conditions (SCF, Flt3L, and IL-7; Figure 2A), which normally promote B cell development

Go back
449.0, 965.0
21.0, 21.0

p27

p28

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 MO000019394

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1
stoichiometry:c67 : 1

m155666*m3961*0.1

nodelay

--

true

0

false

PMID: 18472258,16782035 Indeed, the TLR2 ligand Pam3CSK4 or TLR4 ligand LPS efficiently redirects the developmental fate of wild-type CLPs toward DC differentiation under lymphoid culture conditions (SCF, Flt3L, and IL-7; Figure 2A), which normally promote B cell development

Go back
582.0, 1002.0
19.0, 19.0

p29

p29

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e76 MO000017046 MO000016830 MO000090399

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c73 : 1
stoichiometry:c75 : 1
stoichiometry:c77 : 1
stoichiometry:c69 : 1

m76*m1943*m1767*m63933*0.1

nodelay

--

true

0

false

PMID: 18472258, 16782035 Indeed, the TLR2 ligand Pam3CSK4 or TLR4 ligand LPS efficiently redirects the developmental fate of wild-type CLPs toward DC differentiation under lymphoid culture conditions (SCF, Flt3L, and IL-7; Figure 2A), which normally promote B cell development

Go back
198.0, 278.0
19.0, 19.0

p2

p3

cso30:i:CE_CellDifferentiation

cso30:i:CC_CellComponent

--

e1

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1

m1*0.1

nodelay

--

true

0

false

PMID: 18472258,15851035 Erythroid cells and megakaryocytes largely arise from CMPs, while myeloid cells can develop from either CMPs or LMPPs

Go back
402.0, 830.0
19.0, 19.0

p29

p30

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e75 MO000017046 MO000016830 MO000090399

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c72 : 1
stoichiometry:c74 : 1
stoichiometry:c76 : 1
stoichiometry:c71 : 1

m75*m1943*m1767*m63933*0.1

nodelay

--

true

0

false

PMID: 18472258, 16782035 Indeed, the TLR2 ligand Pam3CSK4 or TLR4 ligand LPS efficiently redirects the developmental fate of wild-type CLPs toward DC differentiation under lymphoid culture conditions (SCF, Flt3L, and IL-7; Figure 2A), which normally promote B cell development

Go back
194.0, 1246.0
19.0, 19.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010325

MO000019417

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m93306*0.1

nodelay

--

true

0

false

PMID: 18472258,12881423 Retroviral expression of C/EBPalpha, GATA1, or GATA2 strongly enhances the macrophage differentiation potential of Pax5 knockout pro-B cells under lymphoid culture conditions (IL-7 plus stromal ST2 cells), whereas GATA1 expression induces erythroblast development in the presence of erythropoietin and stem cell factor (SCF)

Go back
314.0, 1342.0
19.0, 19.0

p31

p32

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011500

MO000032476

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1

m94377*0.1

nodelay

--

true

0

false

PMID: 18472258,12881423 Retroviral expression of C/EBPalpha, GATA1, or GATA2 strongly enhances the macrophage differentiation potential of Pax5 knockout pro-B cells under lymphoid culture conditions (IL-7 plus stromal ST2 cells), whereas GATA1 expression induces erythroblast development in the presence of erythropoietin and stem cell factor (SCF)

Go back
310.0, 1386.0
19.0, 19.0

p31

p33

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011631

MO000032474

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m94470*0.1

nodelay

--

true

0

false

PMID: 18472258,12881423 Retroviral expression of C/EBPalpha, GATA1, or GATA2 strongly enhances the macrophage differentiation potential of Pax5 knockout pro-B cells under lymphoid culture conditions (IL-7 plus stromal ST2 cells), whereas GATA1 expression induces erythroblast development in the presence of erythropoietin and stem cell factor (SCF)

Go back
455.0, 1247.0
17.0, 17.0

p34

p34

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000019417 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c85 : 1

m3982*m102*0.1

nodelay

--

true

0

false

PMID: 18472258,12881423 Retroviral expression of C/EBPalpha, GATA1, or GATA2 strongly enhances the macrophage differentiation potential of Pax5 knockout pro-B cells under lymphoid culture conditions (IL-7 plus stromal ST2 cells), whereas GATA1 expression induces erythroblast development in the presence of erythropoietin and stem cell factor (SCF)

Go back
459.0, 1295.0
17.0, 17.0

p34

p35

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000032476 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m11427*m102*0.1

nodelay

--

true

0

false

PMID: 18472258,12881423 Retroviral expression of C/EBPalpha, GATA1, or GATA2 strongly enhances the macrophage differentiation potential of Pax5 knockout pro-B cells under lymphoid culture conditions (IL-7 plus stromal ST2 cells), whereas GATA1 expression induces erythroblast development in the presence of erythropoietin and stem cell factor (SCF)

Go back
443.0, 1375.0
17.0, 17.0

p34

p36

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000032474 e102

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c91 : 1
stoichiometry:c92 : 1

m11425*m102*0.1

nodelay

--

true

0

false

PMID: 18472258,12881423 Retroviral expression of C/EBPalpha, GATA1, or GATA2 strongly enhances the macrophage differentiation potential of Pax5 knockout pro-B cells under lymphoid culture conditions (IL-7 plus stromal ST2 cells), whereas GATA1 expression induces erythroblast development in the presence of erythropoietin and stem cell factor (SCF)

Go back
515.0, 1335.0
17.0, 17.0

p34

p37

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000032476 e105 e104

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m11427*m105*m104*0.1

nodelay

--

true

0

false

PMID: 18472258,12881423 Retroviral expression of C/EBPalpha, GATA1, or GATA2 strongly enhances the macrophage differentiation potential of Pax5 knockout pro-B cells under lymphoid culture conditions (IL-7 plus stromal ST2 cells), whereas GATA1 expression induces erythroblast development in the presence of erythropoietin and stem cell factor (SCF)

Go back
638.0, 714.0
19.0, 19.0

p38

p38

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

e107

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m107*0.1

nodelay

--

true

0

false

PMID: 18472258,14499119 Moreover, CLPs fail to realize their B cell potential upon forced expression of GATA1, but instead develop into megakaryocytes and erythrocytes (MegE) even under lymphoid cytokine conditions (SCF and IL-7)

Go back
657.0, 1025.0
21.0, 21.0

p39

p39

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e108 MO000016830 e105

e109 e110

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c103 : 1

m108*m1767*m105*0.1

nodelay

--

true

0

false

--

Go back
282.0, 278.0
19.0, 19.0

p2

p4

cso30:i:CE_CellDifferentiation

cso30:i:CC_CellComponent

--

e2

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c9 : 1
stoichiometry:c10 : 1

m2*0.1

nodelay

--

true

0

false

PMID: 18472258,15851035 Erythroid cells and megakaryocytes largely arise from CMPs, while myeloid cells can develop from either CMPs or LMPPs

Go back
399.0, 539.0
17.0, 17.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e70

e151

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m70*0.1

nodelay

--

true

0

false

PMID: 18472258,16407117 Likewise, retroviral C/EBPalpha expression efficiently diverts CLPs as well as DN1 and DN2 pro-T cells into the GM lineages

Go back
710.0, 598.0
19.0, 19.0

p41

p41

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e151

e67 e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1

m151*0.1

nodelay

--

true

0

false

PMID: 18472258,16407117 Likewise, retroviral C/EBPalpha expression efficiently diverts CLPs as well as DN1 and DN2 pro-T cells into the GM lineages

Go back
887.0, 1087.0
17.0, 17.0

p40

p42

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e152

e154

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c107 : 1
stoichiometry:c108 : 1

m152*0.1

nodelay

--

true

0

false

PMID: 18472258,16407117 Likewise, retroviral C/EBPalpha expression efficiently diverts CLPs as well as DN1 and DN2 pro-T cells into the GM lineages

Go back
822.0, 834.0
19.0, 19.0

p41

p43

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e154

e67 e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1
stoichiometry:c111 : 1

m154*0.1

nodelay

--

true

0

false

PMID: 18472258,16407117 Likewise, retroviral C/EBPalpha expression efficiently diverts CLPs as well as DN1 and DN2 pro-T cells into the GM lineages

Go back
1215.0, 779.0
17.0, 17.0

p40

p44

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e153

e155

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m153*0.1

nodelay

--

true

0

false

PMID: 18472258,16407117 Likewise, retroviral C/EBPalpha expression efficiently diverts CLPs as well as DN1 and DN2 pro-T cells into the GM lineages

Go back
1046.0, 646.0
19.0, 19.0

p41

p45

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e155

e67 e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m155*0.1

nodelay

--

true

0

false

PMID: 18472258,16407117 Likewise, retroviral C/EBPalpha expression efficiently diverts CLPs as well as DN1 and DN2 pro-T cells into the GM lineages

Go back
101.0, 1233.0
21.0, 21.0

p46

p46

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e169

MO000034634

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m169*0.1

nodelay

--

true

0

false

PMID: 18472258,17603486,12881423 However in the absence of Notch ligands, ectopic GATA3 expression induces myeloid differentiation of Pax5 knockout pro-B cells or mast cell development of DN1 and DN2 pro-T cells

Go back
159.0, 983.0
21.0, 21.0

p47

p47

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000034634

e170

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c119 : 1
stoichiometry:c120 : 1

m13174*0.1

nodelay

--

true

0

false

PMID: 18472258,17603486,12881423 However in the absence of Notch ligands, ectopic GATA3 expression induces myeloid differentiation of Pax5 knockout pro-B cells or mast cell development of DN1 and DN2 pro-T cells

Go back
965.0, 1097.0
21.0, 21.0

p46

p48

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e171

e173

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c123 : 1

m171*0.1

nodelay

--

true

0

false

PMID: 18472258,17603486,12881423 However in the absence of Notch ligands, ectopic GATA3 expression induces myeloid differentiation of Pax5 knockout pro-B cells or mast cell development of DN1 and DN2 pro-T cells

Go back
1233.0, 1017.0
21.0, 21.0

p46

p49

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e172

e174

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c124 : 1

m172*0.1

nodelay

--

true

0

false

PMID: 18472258,17603486,12881423 However in the absence of Notch ligands, ectopic GATA3 expression induces myeloid differentiation of Pax5 knockout pro-B cells or mast cell development of DN1 and DN2 pro-T cells

Go back
338.0, 290.0
19.0, 19.0

p5

p5

cso30:i:CE_CellDifferentiation

cso30:i:CC_CellComponent

--

e2

e7

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m2*0.1

nodelay

--

true

0

false

PMID: 18472258,9393859,17582343 Activation of the lymphoid Rag1 and Rag2 genes in LMPP cells characterizes the emergence of the earliest lymphocyte progenitors (ELPs), which subsequently differentiate into common lymphoid progenitors (CLPs) with their characteristic B, T, and NK cell potential PMID: 18472258,17582341 T cells are also derived from HSCs in the bone marrow and yet develop in the thymus. Several hematopoietic progenitors (MPPs, LMPPs, ELPs, CLPs, and pre?pro-B cells) in the bone marrow have the potential to migrate to the thymus, where they promote T cell development

Go back
1113.0, 1201.0
21.0, 21.0

p47

p50

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e173

e175

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c126 : 1

m173*0.1

nodelay

--

true

0

false

PMID: 18472258,17603486,12881423 However in the absence of Notch ligands, ectopic GATA3 expression induces myeloid differentiation of Pax5 knockout pro-B cells or mast cell development of DN1 and DN2 pro-T cells

Go back
1165.0, 1149.0
21.0, 21.0

p47

p51

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

e174

e175

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m174*0.1

nodelay

--

true

0

false

PMID: 18472258,17603486,12881423 However in the absence of Notch ligands, ectopic GATA3 expression induces myeloid differentiation of Pax5 knockout pro-B cells or mast cell development of DN1 and DN2 pro-T cells

Go back
723.0, 1843.0
17.0, 17.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e195

G011894

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m195*0.1

nodelay

--

true

0

false

PMID: 18472258,17440452 Pax5 directly activates target genes coding for essential components of BCR signaling such as the signal-transducing chain Ig¦Á (CD79a), the costimulatory receptor CD19 and the central adaptor protein BLNK (SLP65)

Go back
755.0, 1875.0
17.0, 17.0

p52

p53

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e195

G010392

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1

m195*0.1

nodelay

--

true

0

false

PMID: 18472258,17440452 Pax5 directly activates target genes coding for essential components of BCR signaling such as the signal-transducing chain Ig¦Á (CD79a), the costimulatory receptor CD19 and the central adaptor protein BLNK (SLP65)

Go back
799.0, 1875.0
17.0, 17.0

p52

p54

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e195

G026871

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m195*0.1

nodelay

--

true

0

false

PMID: 18472258,17440452 Pax5 directly activates target genes coding for essential components of BCR signaling such as the signal-transducing chain Ig¦Á (CD79a), the costimulatory receptor CD19 and the central adaptor protein BLNK (SLP65)

Go back
830.0, 1618.0
19.0, 19.0

p55

p55

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e197 MO000017690

e198

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m197*m2450*0.1

nodelay

--

true

0

false

PMID: 18472258,16546096,17600970,17658281,15738953 ,11420047 Under physiological conditions, Pax5 and its transcription program are downregulated during the terminal differentiation of mature B cells to plasma cells , which is initiated in response to efficient stimulation of the BCR by foreign antigens PMID: 18472258 In response to strong BCR stimulation by foreign antigens, mature B cells repress the Pax5 gene and activate expression of the plasma cell transcription factor Blimp1, which results in terminal differentiation to plasma cells.

Go back
649.0, 1781.0
21.0, 21.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e198

G011496

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c139 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18472258 In response to strong BCR stimulation by foreign antigens, mature B cells repress the Pax5 gene and activate expression of the plasma cell transcription factor Blimp1, which results in terminal differentiation to plasma cells.

Go back
787.0, 1711.0
17.0, 17.0

p57

p57

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G011496

e195

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m94373*0.1

nodelay

--

true

0

false

PMID: 18472258, 17440452 Pax5 directly activates target genes coding for essential components of BCR signaling such as the signal-transducing chain Ig¦Á (CD79a), the costimulatory receptor CD19 and the central adaptor protein BLNK (SLP65) PMID: 18472258, 16546096, 17600970,17658281,15738953,11420047 Under physiological conditions, Pax5 and its transcription program are downregulated during the terminal differentiation of mature B cells to plasma cells, which is initiated in response to efficient stimulation of the BCR by foreign antigens

Go back
749.0, 1781.0
21.0, 21.0

p56

p58

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e198

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c142 : 1

m198*0.1

nodelay

--

true

0

false

PMID: 18472258 In response to strong BCR stimulation by foreign antigens, mature B cells repress the Pax5 gene and activate expression of the plasma cell transcription factor Blimp1, which results in terminal differentiation to plasma cells.

Go back
849.0, 1969.0
17.0, 17.0

p59

p59

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e20

MO000118017

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18472258 In response to strong BCR stimulation by foreign antigens, mature B cells repress the Pax5 gene and activate expression of the plasma cell transcription factor Blimp1, which results in terminal differentiation to plasma cells.

Go back
426.0, 358.0
19.0, 19.0

p5

p6

cso30:i:CE_CellDifferentiation

cso30:i:CC_CellComponent

--

e7

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1

m7*0.1

nodelay

--

true

0

false

PMID: 18472258,9393859,17582343 Activation of the lymphoid Rag1 and Rag2 genes in LMPP cells characterizes the emergence of the earliest lymphocyte progenitors (ELPs), which subsequently differentiate into common lymphoid progenitors (CLPs) with their characteristic B, T, and NK cell potential

Go back
1018.0, 1918.0
19.0, 19.0

p60

p60

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000118017

e199

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m87014*0.1

nodelay

--

true

0

false

PMID: 18472258 In response to strong BCR stimulation by foreign antigens, mature B cells repress the Pax5 gene and activate expression of the plasma cell transcription factor Blimp1, which results in terminal differentiation to plasma cells.

Go back
478.0, 594.0
19.0, 19.0

p7

p7

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000032503 MO000092644

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c14 : 1
stoichiometry:c15 : 1
stoichiometry:c16 : 1

m11454*m362249*0.1

nodelay

--

true

0

false

PMID: 18472258,10435576,15361869 E2A and EBF1 coordinately activate the expression of B-lymphoid genes partly by acting as ¡Æpioneer¡Ç factors to initiate epigenetic changes and chromatin remodeling at the onset of B cell development

Go back
543.0, 583.0
19.0, 19.0

p8

p8

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000037161

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c17 : 1
stoichiometry:c18 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18472258,16546096,17658281 At the molecular level, Pax5 fulfills a dual role by repressing the transcription of B-lineage-inappropriate genes and by activating the expression of B-cell-specific genes during B cell commitment.

Go back
599.0, 607.0
17.0, 17.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

MO000037161

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1

m15456*0.1

nodelay

--

true

0

false

PMID: 18472258,16546096,17658281 At the molecular level, Pax5 fulfills a dual role by repressing the transcription of B-lineage-inappropriate genes and by activating the expression of B-cell-specific genes during B cell commitment.

Go back
107.0, 116.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
272.4997257507944, 297.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
241.0, 570.0

c100

c100

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
454.0, 1041.3367907179836

c101

c101

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
639.4743934852801, 1046.0

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
673.0, 1046.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 508.0

c104

c104

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
729.0, 609.0

c105

c105

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
723.0, 617.0

c106

c106

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
899.5689290811055, 1111.8446454055274

c107

c107

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 1055.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.51657315371, 860.5938698673355

c109

c109

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
276.0, 228.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
835.0, 651.7264944053211

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
784.5066945971321, 774.6098187424603

c111

c111

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1225.5206330987648, 803.9830408477266

c112

c112

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1218.0809056378664, 742.9266413443544

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.3720914197193, 663.1068099554531

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.8148278218915, 625.7112761653777

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.6586216862937, 659.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.08462869405115, 1261.92613276422

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
119.0, 1195.8185818291893

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
153.0, 1011.9635338723242

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
357.0, 300.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
166.5321520841902, 945.9822812628529

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.319744306791, 1125.9936076697743

c121

c121

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1254.0944414007565, 923.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
976.0, 1061.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1196.9917483216825, 1029.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
984.0, 1053.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1134.0, 1217.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.296093284079, 1041.0

c127

c127

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1181.0, 1170.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0046899112375, 1742.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
436.0, 324.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.4536640138874, 1856.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
774.5174713247359, 1742.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
722.2625860380489, 1891.0

c132

c132

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
814.913082411211, 1742.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
778.5455257366611, 1892.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
856.8958944955403, 1598.0

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 1578.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.8599434057004, 1634.0

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.7456957707635, 1674.0

c138

c138

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
670.0, 1784.379042654018

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
490.10918275627523, 494.0

c14

c14

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
737.0, 1732.1455366913863

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
804.0, 1721.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
713.3174928327581, 1797.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0, 1841.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
865.0, 1944.4247842258703

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
906.0, 1928.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1037.0, 1921.6832091307715

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.48247494163365, 526.0

c15

c15

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.0573097607281, 613.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.3357178967731, 526.0

c17

c17

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
554.0, 602.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
608.0, 526.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
172.6006381480884, 126.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
581.421926492615, 624.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
242.0, 560.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 560.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.0, 504.9349894126538

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
363.0, 507.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
763.1831076448378, 1674.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
134.0, 52.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
103.35246541969397, 62.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
699.0, 115.30007459611961

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.6656542647312, 52.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
203.0, 126.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
207.0, 65.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
260.0, 109.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
276.0, 216.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
718.0, 108.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.0, 303.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
745.0, 193.0

c35

c35

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
862.0, 322.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
745.0, 190.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
919.0, 310.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 641.9504845910735

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
160.0, 250.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
821.0, 625.9734342450795

c40

c40

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.3260780821423, 649.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.8018287567196, 845.5080652753668

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
892.0, 652.0

c43

c43

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.1660445877833, 840.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.4057970281387, 586.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.0046214722144, 633.8646187432906

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.4376015698018, 725.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1001.9540091220535, 789.8565855977596

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
908.8492760207721, 651.0130645309956

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
114.0, 312.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.0, 802.0

c50

c50

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
751.0, 650.8713029138188

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 775.9028223726551

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.8398985566564, 748.5924793943209

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.0, 878.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
766.1386774474314, 797.0

c55

c55

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.56316647596276, 562.5709597253864

c56

c56

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
416.0, 519.4513482233507

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
404.70984017501604, 713.1350326638506

c58

c58

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
367.7165612572172, 715.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
160.0, 321.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
513.319744306791, 752.0

c60

c60

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
512.0, 821.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
306.0, 732.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
285.0, 686.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
298.0, 740.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
416.0, 976.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
469.8041362749238, 891.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 893.5685159055888

c67

c67

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 899.0

c68

c68

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.0, 991.2951848187461

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
181.0, 249.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
361.0, 792.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
421.0, 844.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
282.0, 829.0

c72

c72

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
282.0, 834.0

c73

c73

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
238.0, 570.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
240.0, 570.0

c75

c75

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
296.0, 848.468479984129

c76

c76

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
296.0, 903.0

c77

c77

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
191.0, 1272.7895054303715

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
213.0, 1256.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
214.0, 297.0

c8

c8

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
235.0, 1355.8707072438638

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
324.0, 1319.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
251.0, 1403.0143850336156

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
321.0, 1405.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
327.0, 1256.0

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
472.0, 1234.73373639593

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.0, 1171.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
335.0, 1300.0

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
401.0, 1176.0

c88

c88

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
476.0, 1240.197769023179

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
270.0, 236.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
339.0, 1393.1927794053147

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
397.0, 1177.0

c91

c91

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
460.0, 1247.9220899170605

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
335.0, 1302.0

c93

c93

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
447.0, 1112.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
451.0, 1358.1709862283205

c95

c95

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
532.0, 1345.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 688.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
614.9711254108329, 733.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
611.0, 835.0

c99

c99

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back