1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18534908.csml convertedTime:2009.07.01.11:19

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Turning NF-kappaB and IRFs on and off in DC.
Authors Kaisho T, Tanaka T.
Affiliation Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology,Yokohama city, Kanagawa 230-0045, Japan. tkaisho@rcai.riken.jp
Abstract Dendritic cells (DCs) produce an array of cytokines after detecting variousimmune adjuvants through pattern recognition receptors (PRRs). PRR signalingleads to activation of transcription factors such as NF-kappaB or interferonregulatory factors (IRFs) but after activation must be attenuated to avoidimmunopathology and to maintain tissue homeostasis. IkappaB kinase familymembers, originally identified as classical NF-kappaB activators, are now foundto be broadly and crucially involved in PRR signaling in a member-specificmanner. Furthermore, a new mechanism for NF-kappaB downregulation is emergingthat involves the degradation of active NF-kappaB by the nuclearubiquitin-proteasome system. Here we review new aspects of NF-kappaB and IRFregulation chiefly in DCs.
PMID 18534908
Model Abstract

Entity

G010713:IRF-7 MO000000030:PI3K MO000000204:TNF MO000000205:TNFR MO000000210:IKK-alpha MO000000214:IL-1 MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016595:IL-1RI MO000016608:IKK-i MO000016882:LPS MO000016922:CD40 MO000016963:TRAF3 MO000017197:Pin1 MO000019331:TBK1 MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019479:protein remnants MO000022224:dsRNA MO000033291:IKK-alpha:IKK-beta MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 MO000044940:HMGB1 MO000061425:ZBP1 MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 e1: e10: e100:IRF-3{p}:pin1 e101:PDLIM2 e102:IRF-3{p}{ub}:pin1 e103:p50:p65:PDLIM2 e104:p50:p65{ub}:PDLIM2 e105:p50 e106:p50:p65 e107:ECS e108:p50:p65{p}{ub} e109:p50 e11:IL1:ILRI e12:TNF:TNFR e13:TLR ligand:TLR:MYD88 e14:TLR ligand:TLR:TRIF e15:IL1:IL1R:MYD88 e16:IKK-alpha:IKK-beta{active} e17:(IKK-beta)2 e18:(IKK-beta)2 e19:p100:RelB e2: e20:p100{p}:RelB e21:TNF e22:CD40L e23:CD40L:CD40 e24:LTbetaR e25:LTbeta e26:LTbeta:LTbetaR e27:BAFFR ligand:BAFFR e28:BAFF-R e29:BAFFR ligand e3: e30:p50:p65 e31:p50:p65:IkappaB{p} e32:p50:p65:IkappaB e33:(IKK-alpha)2 e34:(IKK-alpha)2 active e35:p52:RelB e36:BLC e37:SLC e38: e39: e4: e40: e41:IL-6 e42:IL-12 e43:LPS:TLR4 e44:Ikk-alpha:promoter:histone H3 e45:NF-kappaB responsive promoter:histone H3 e46:Ikk-alpha:promoter:histone H3{p} e47:Ikk-alpha:promoter:histone H3{p}{ace} e48:LPS:TLR4:MYD88 e49:LPS:TLR4:TRIF e5:TLR ligand e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR ligand:TLR e60: e61: e62: e63:TBK1:IKK-i e64:TBK1:IKK-i{active} e65:(IRF-3{p})2 e66:(IRF-3{p})2 e67:IFN-beta e68:dsRNA:DDX58 e69:dsRNA:IFIH1 e7: e70:dsRNA:IFIH1:MAVS e71:dsRNA:DDX58:MAVS e72:IFN-alpha e73:dsDNA e74:dsDNA:ZBP1 e75:p65{p}:p50 e76:ssRNA:TLR7 e77:ssRNA e78:CpG DNA e79:CpGDNA:TLR9 e8: e80:DNA:TLR9:MYD88 e81:ssRNA:TLR7:MYD88 e82:IKK-alpha e83:IKK-alpha{active} e84:IRF-7{p} e85:osteopontin e86:IRAK-1{active} e87:IRAK-1 e88:DNA e89:DNA:HMGB1 e9: e90:LL37 e91:DNA:LL37 e92:DNA:LL37 e93:IkappaB-alpha e94:Ikappa-Balpha e95:p50:p65:IkappaB-alpha e96:(IRF-3{p})2{ub} e97:IRF-7{p}{ub} e98:E3 ligase e99:protein remnants

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98
Model Detail
485.0, 1373.0
30.0, 30.0

IRF-7

--

G010713

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p60

--

true true true true

csml-variable:Double

m93631

10

false

infinite

0

unit false false false
TRANSFACG010713

--

Go back
410.0, 1546.0
28.0, 28.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p70

true true true true

csml-variable:Double

m85

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1055.0, 75.0
18.0, 18.0

TNF

--

MO000000204

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p33

true true true true

csml-variable:Double

m175

10

false

infinite

0

unit false false false
TRANSPATHMO000000204

--

Go back
1089.0, 241.0
22.0, 22.0

TNFR

--

MO000000205

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m176

10

false

infinite

0

unit false false false
TRANSPATHMO000000205

--

Go back
753.0, 1389.0
22.0, 22.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1165.0, 93.0
22.0, 22.0

IL-1

--

MO000000214

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m185

10

false

infinite

0

unit false false false
TRANSPATHMO000000214

--

Go back
1118.0, 1062.0
28.0, 28.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
351.0, 1147.0
34.0, 34.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p69 p77

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1089.0, 361.0
22.0, 22.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p6 p37 p63 p64

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1216.0, 240.0
24.0, 24.0

IL-1RI

--

MO000016595

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1589

10

false

infinite

0

unit false false false
InterProIPR004076
TRANSPATHMO000016595

--

Go back
1006.0, 806.0
20.0, 20.0

IKK-i

--

MO000016608

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m1599

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016608

--

Go back
1511.0, 559.0
26.0, 26.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
272.0, 340.0
32.0, 32.0

CD40

--

MO000016922

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m1837

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000016922

--

Go back
549.0, 1673.0
30.0, 30.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73 p74

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
1216.0, 1136.0
32.0, 32.0

Pin1

--

MO000017197

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p90

true true true true

csml-variable:Double

m2065

10

false

infinite

0

unit false false false
InterProIPR000297
TRANSPATHMO000017197

--

Go back
857.0, 833.0
22.0, 22.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p41

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1255.0, 555.0
34.0, 34.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
1273.0, 261.0
30.0, 30.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
692.0, 456.0
24.0, 24.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
809.0, 889.0
22.0, 22.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p17 p98

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
811.0, 375.0
26.0, 26.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p46 p47

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
877.0, 544.0
36.0, 36.0

IKK-alpha:IKK-beta

--

MO000033291

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p9 p7 p8 p10

true true true true

csml-variable:Double

m11981

10

false

infinite

0

unit false false false
TRANSPATHMO000033291

--

Go back
1214.0, 438.0
19.0, 19.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p36 p38

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
727.0, 547.0
26.0, 26.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36

p40

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
710.0, 498.0
28.0, 28.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p36

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
1162.0, 1210.0
28.0, 28.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

p43 p90

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
356.0, 1344.0
32.0, 32.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58 p69 p77

p70

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
568.0, 668.0
32.0, 32.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p62

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
567.0, 471.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
75.0, 711.0
26.0, 26.0

HMGB1

--

MO000044940

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p80

true true true true

csml-variable:Double

m22603

10

false

infinite

0

unit false false false
TRANSPATHMO000044940

--

Go back
1177.0, 1641.0
22.0, 22.0

ZBP1

--

MO000061425

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m36323

10

false

infinite

0

unit false false false
TRANSPATHMO000061425

--

Go back
939.0, 311.0
26.0, 26.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p46

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
643.0, 315.0
34.0, 34.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48 p49

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
725.0, 321.0
30.0, 30.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
248.63584090585525, 221.89466217813413
1085.1907974609728, 1575.697037913331

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
259.0915786800393, 245.97846178484508
1051.8821968986695, 1479.702477993265

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1165.0, 1076.1878453038676
21.430939226519335, 23.812154696132595

IRF-3{p}:pin1

--

e100

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

p91

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
671.5, 1118.0609780639968
16.61239686053532, 26.939021936003225

PDLIM2

--

e101

cso30:c:Protein

cso30:i:CC_Extracellular

--

p94

p92

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1167.0, 926.0441988950276
25.16022099447514, 27.955801104972377

IRF-3{p}{ub}:pin1

--

e102

cso30:c:Complex

cso30:i:CC_Extracellular

--

p91

--

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
712.5, 1159.9333822719766
23.697742705083503, 33.066617728023495

p50:p65:PDLIM2

--

e103

cso30:c:Complex

cso30:i:CC_Extracellular

--

p92

p93

true true true true

csml-variable:Double

m104

0

false

infinite

0

unit false false false

--

Go back
797.5, 1209.137639933933
21.40135804734814, 29.862360066067165

p50:p65{ub}:PDLIM2

--

e104

cso30:c:Complex

cso30:i:CC_Extracellular

--

p93

p94

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
816.0, 1086.62
23.839999999999996, 17.879999999999995

p50

--

e105

cso30:c:Protein

cso30:i:CC_Extracellular

--

p94

--

true true true true

csml-variable:Double

m106

0

false

infinite

0

unit false false false

--

Go back
665.5, 882.6157307115482
28.080486585569073, 34.38426928845193

p50:p65

--

e106

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p55

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
476.5, 1083.781244265003
23.090108276748026, 32.218755734997245

ECS

--

e107

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p97

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
351.5, 1061.1349775037495
24.389768371938008, 29.865022496250628

p50:p65{p}{ub}

--

e108

cso30:c:Complex

cso30:i:CC_Extracellular

--

p97

p98

true true true true

csml-variable:Double

m109

0

false

infinite

0

unit false false false

--

Go back
392.0, 963.1400000000001
24.479999999999997, 18.359999999999996

p50

--

e109

cso30:c:Protein

cso30:i:CC_Extracellular

--

p98

--

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1166.5, 232.824161368121
19.724183293137465, 38.17583863187897

IL1:ILRI

--

e11

cso30:c:Complex

cso30:i:CC_Cytosol

--

p2

p6

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1035.5, 235.55974566980922
16.76079807059855, 32.44025433019075

TNF:TNFR

--

e12

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p13 p10

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1271.5, 394.2376582859241
24.91301156175445, 34.76234171407598

TLR ligand:TLR:MYD88

--

e13

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p11 p8

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1277.5, 477.37988621765476
21.227748210680854, 29.620113782345385

TLR ligand:TLR:TRIF

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p12 p7

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
941.5, 233.07157276564504
21.44870618462103, 29.92842723435493

IL1:IL1R:MYD88

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

p14 p9

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
853.0, 748.0
36.0, 36.0

IKK-alpha:IKK-beta{active}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p9 p7 p8 p10

p15

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000033291

--

Go back
1024.5, 614.4845859023497
22.470921513081148, 27.515414097650392

(IKK-beta)2

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p11 p12 p13 p14 p95

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1060.5, 762.5132477920346
15.914180969838355, 19.486752207965328

(IKK-beta)2

--

e18

cso30:c:Complex

cso30:i:CC_Cytosol

--

p11 p12 p13 p14 p95

p16

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
488.0, 654.2651933701657
24.961325966850826, 27.734806629834257

p100:RelB

--

e19

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p25

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
248.63584090585525, 221.89466217813413
1085.1907974609728, 1575.697037913331

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
338.0, 652.8895027624308
27.099447513812155, 30.11049723756906

p100{p}:RelB

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
727.0, 1313.0484429065746
41.159169550173004, 21.951557093425606

TNF

--

e21

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p18

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
106.0, 270.97100175746925
28.506151142355012, 18.528998242530754

CD40L

--

e22

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p19

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
277.5, 392.1797851348388
20.573777680333258, 39.82021486516115

CD40L:CD40

--

e23

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p23

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
273.5, 486.48506151142357
28.284710017574696, 43.51493848857645

LTbetaR

--

e24

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p20

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
67.0, 497.01845342706497
34.58699472759227, 22.481546572934974

LTbeta

--

e25

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p20

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
273.5, 567.0484542863408
21.158298618723965, 40.951545713659286

LTbeta:LTbetaR

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p20

p24

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
301.5, 228.62705547029162
20.342688007016005, 39.3729445297084

BAFFR ligand:BAFFR

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p22

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
360.5, 225.6555360281195
23.623901581722322, 36.344463971880494

BAFF-R

--

e28

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p21

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
374.0, 67.2739987925136
31.17729925538337, 19.22600120748642

BAFFR ligand

--

e29

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
270.3396568550749, 243.5984781273537
1041.7831655625337, 1532.289406014893

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
595.5, 1256.4150974837528
24.977670388268624, 30.584902516247297

p50:p65

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p96

p18 p29 p30 p83 p85 p92

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
732.5, 807.8583226280052
23.034868783262986, 32.14167737199486

p50:p65:IkappaB{p}

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15 p16

p17

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
608.5, 743.4839420077079
23.303174894476054, 32.51605799229217

p50:p65:IkappaB

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

p15 p16

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
455.5, 381.99333444425923
16.338776870521585, 20.006665555740717

(IKK-alpha)2

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p22 p23 p24

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
451.5, 525.243626062323
17.767705382436265, 21.756373937677058

(IKK-alpha)2 active

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22 p23 p24

p25

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
337.5, 870.035994001
29.37060489918347, 35.96400599900017

p52:RelB

--

e35

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p27 p28

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
563.0, 1177.0484429065746
41.159169550173004, 21.951557093425606

BLC

--

e36

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p27

--

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
639.0, 1312.9377162629758
41.36678200692042, 22.062283737024224

SLC

--

e37

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p28

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
572.0, 426.7837028046954
168.60755124874328, 281.488877932224

--

e38

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false true false

--

Go back
572.0, 426.7837028046954
168.60755124874328, 281.488877932224

--

e39

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false true false

--

Go back
310.49171636113056, 281.5801560384873
961.4790465504216, 1456.3260501926243

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
572.0, 426.7837028046954
168.60755124874328, 281.488877932224

--

e40

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false true false

--

Go back
782.0, 1338.733564013841
36.12456747404844, 19.266435986159173

IL-6

--

e41

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p29

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
838.0, 1288.5813148788927
43.91003460207613, 23.418685121107266

IL-12

--

e42

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p30

--

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1265.5, 628.6007454505591
20.35628151721114, 39.39925454944091

LPS:TLR4

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p31

p37 p38

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
898.0, 1455.5
60.0, 17.0

Ikk-alpha:promoter:histone H3

--

e44

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p33

p34

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
650.0, 1455.5
60.0, 17.0

NF-kappaB responsive promoter:histone H3

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p33

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
818.0, 1499.5
60.0, 17.0

Ikk-alpha:promoter:histone H3{p}

--

e46

cso30:c:Complex

cso30:i:CC_Nucleolus

--

p34

p35

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
570.0, 1499.5
60.0, 17.0

Ikk-alpha:promoter:histone H3{p}{ace}

--

e47

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p35

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1263.5, 705.9823820884567
25.812626169939442, 36.017617911543404

LPS:TLR4:MYD88

--

e48

cso30:c:Complex

cso30:i:CC_Extracellular

--

p37

p95

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
1261.5, 779.4677922554598
29.04808221692054, 40.53220774454029

LPS:TLR4:TRIF

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p38

p39

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
1339.0, 248.9956063268893
34.62214411247804, 22.504393673110727

TLR ligand

--

e5

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p1

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
416.18035274161343, 1052.8265135006616
675.902684009152, 612.9694732075559

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
489.1828772714666, 1067.352998898232
395.22056383402935, 594.0895099670768

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
424.99100225383694, 1061.0078309048683
658.2813849847048, 596.6068383991404

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
426.24966646986894, 1062.2664951209013
655.7640565526411, 594.0895099670768

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
416.18035274161343, 1052.8265135006616
675.902684009152, 612.9694732075559

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
416.18035274161343, 1052.8265135006616
675.902684009152, 612.9694732075559

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
426.24966646986894, 1062.2664951209013
655.7640565526411, 594.0895099670768

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
909.5767254261337, 1304.55935670705
42.226685946841, 38.22626306766665

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
798.8142744153231, 1480.7723469515208
119.57310052303428, 108.24512257874707

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
416.18035274161343, 1052.8265135006616
675.902684009152, 612.9694732075559

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
1273.5, 327.0747643060732
21.14470510852883, 40.925235693926766

TLR ligand:TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p4 p5

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
575.4868123199368, 1325.225082385643
21.4048448678984, 10.30603641787704

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
574.7720439616376, 1294.4900429787929
73.26375672563272, 131.87476210613906

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
605.5070833684889, 1380.2622459746567
11.436293732781685, 11.436293732781714

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
976.0, 866.8121546961327
23.56906077348066, 26.187845303867405

TBK1:IKK-i

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p39 p40 p50 p51 p54

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1045.0, 1007.6243093922652
29.138121546961333, 32.37569060773482

TBK1:IKK-i{active}

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39 p40 p50 p51 p54

p42 p55 p56 p57 p58

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1162.0, 1440.5580110497237
27.39779005524862, 30.441988950276244

(IRF-3{p})2

--

e65

cso30:c:Complex

cso30:i:CC_Cytosol

--

p43

p44

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
979.0, 1353.1104972375688
26.90055248618785, 29.88950276243094

(IRF-3{p})2

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p45 p52 p60 p87

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
912.0, 1211.4498269896194
32.90657439446366, 17.55017301038062

IFN-beta

--

e67

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p45 p56 p68 p72 p74 p76

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
841.0, 356.29834254143645
21.331491712707187, 23.701657458563545

dsRNA:DDX58

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p46

p49

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
655.5, 377.1236460589902
17.865689051824692, 21.87635394100983

dsRNA:IFIH1

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p48

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
262.89366514337905, 228.23539162259328
1064.2340825589242, 1507.992205544749

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
536.5, 371.70416590200034
23.145347770233073, 32.29583409799964

dsRNA:IFIH1:MAVS

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p50

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
890.5, 374.6592035235825
19.59423747476601, 27.340796476417694

dsRNA:DDX58:MAVS

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p49

p51

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
826.0, 1412.4705882352941
44.11764705882353, 23.529411764705884

IFN-alpha

--

e72

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p52 p57 p67 p71 p73 p75

--

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
998.0, 1644.3307349665924
43.340757238307354, 15.169265033407573

dsDNA

--

e73

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p53

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1102.5, 1547.295450758207
26.70871521413097, 32.70454924179301

dsDNA:ZBP1

--

e74

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
536.5, 921.694884185969
23.932511248125312, 29.305115814031

p65{p}:p50

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p96 p97

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
571.5, 527.0993203244902
16.998684499013375, 32.90067967550976

ssRNA:TLR7

--

e76

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p61

p64

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
483.0, 582.5633632975224
34.71607103705328, 17.936636702477525

ssRNA

--

e77

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p61

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
502.0, 721.5
60.0, 13.0

CpG DNA

--

e78

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p62

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
567.5, 619.4545055908792
16.815172111379084, 32.545494409120806

CpGDNA:TLR9

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

p63

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
266.6957516067188, 254.84999686597098
1020.9324365677244, 1482.3938978963367

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
617.5, 690.0535878142779
20.028262066434205, 27.946412185722153

DNA:TLR9:MYD88

--

e80

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

p66 p78

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
572.5, 575.2306845292715
23.48467608735548, 32.76931547072858

ssRNA:TLR7:MYD88

--

e81

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p64

p65 p79

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
417.0, 757.0
22.0, 22.0

IKK-alpha

--

e82

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p65 p66

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
428.0, 908.0
23.0, 23.0

IKK-alpha{active}

--

e83

cso30:c:Protein

cso30:i:CC_CellComponent

--

p65 p66

p67 p68 p69

true true true true

csml-variable:Double

m83

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
540.0, 1312.0
32.0, 32.0

IRF-7{p}

--

e84

cso30:c:Protein

cso30:i:CC_CellComponent

--

p70

p71 p72 p88

true true true true

csml-variable:Double

m84

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
914.0, 1678.9
36.8, 27.6

osteopontin

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p75 p76

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
486.0, 889.9579045837231
19.51824134705332, 45.042095416276894

IRAK-1{active}

--

e86

cso30:c:Protein

cso30:i:CC_Extracellular

--

p78 p79

p77

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
546.0, 781.9579045837231
19.51824134705332, 45.042095416276894

IRAK-1

--

e87

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p78 p79

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
50.0, 920.6714922048998
39.510022271714924, 13.828507795100224

DNA

--

e88

cso30:c:Dna

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

p80 p81

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
153.0, 826.8563535911602
30.729281767955797, 34.14364640883978

DNA:HMGB1

--

e89

cso30:c:Complex

cso30:i:CC_Extracellular

--

p80

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
276.83464884229124, 281.46460210934873
1016.2713199782384, 1462.9526733797265

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
60.5, 1055.1114912457235
15.964580398470517, 25.88850875427651

LL37

--

e90

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p81

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
118.0, 1091.8453038674033
28.939226519337016, 32.15469613259668

DNA:LL37

--

e91

cso30:c:Complex

cso30:i:CC_Extracellular

--

p81

p82

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
635.0, 465.8287292817679
26.25414364640884, 29.171270718232037

DNA:LL37

--

e92

cso30:c:Complex

cso30:i:CC_Extracellular

--

p82

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
697.0, 1265.7923875432527
37.88927335640138, 20.207612456747405

IkappaB-alpha

--

e93

cso30:c:mRNA

cso30:i:CC_Cytosol

--

p83

p84

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
895.0, 1130.6394646810222
41.93600321996378, 25.860535318977664

Ikappa-Balpha

--

e94

cso30:c:Protein

cso30:i:CC_Cytosol

--

p84

p85

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
534.5, 1466.5931363552945
19.64158561203891, 27.406863644705457

p50:p65:IkappaB-alpha

--

e95

cso30:c:Complex

cso30:i:CC_Extracellular

--

p85

p86

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
1005.0, 1257.0930720783765
37.70468859342198, 28.906927921623517

(IRF-3{p})2{ub}

--

e96

cso30:c:Protein

cso30:i:CC_Cytosol

--

p87

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
472.0, 1227.2456263121067
32.28831350594821, 24.754373687893633

IRF-7{p}{ub}

--

e97

cso30:c:Protein

cso30:i:CC_Extracellular

--

p88

p89

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
447.0, 1320.3180542563143
17.195509822263794, 39.68194574368568

E3 ligase

--

e98

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p88

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
713.0, 1097.0
22.0, 22.0

protein remnants

--

e99

cso30:c:Protein

cso30:i:CC_CellComponent

--

p89 p94

--

true true true true

csml-variable:Double

m100

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
1348.0, 340.0
15.0, 15.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000019395

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c2 : 1
stoichiometry:c3 : 1
stoichiometry:c1 : 1

m5*m3962*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is essential for the classical or canonical NF-¦ÊB activation pathway, which functions downstream of tumor necrosis factor receptor (TNFR), IL-1 receptors (IL-1Rs), Toll-like receptors (TLRs) and RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs).

Go back
774.0, 641.5
17.5, 17.5

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000033291 e12

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c29 : 1

m11981*m12*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes

Go back
1060.0, 684.0
15.0, 15.0

p11

p11

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e13

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m17*m13*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation. PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes

Go back
1003.0, 691.0
17.0, 17.0

p12

p12

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e14

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c36 : 1
stoichiometry:c35 : 1

m17*m14*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation. PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes

Go back
957.0, 677.0
21.0, 21.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e12

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c39 : 1
stoichiometry:c38 : 1

m17*m12*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes

Go back
1114.0, 674.0
19.0, 19.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e15

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c42 : 1
stoichiometry:c41 : 1

m17*m15*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes

Go back
638.0, 814.0
19.0, 19.0

p15

p15

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e16 e32

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c45 : 1
stoichiometry:c43 : 1
stoichiometry:c46 : 1

m16*m32*0.1

nodelay

--

true

0

false

PMID: 18534908 Upon various stimuli, I¦ÊB is phosphorylated and degraded, thereby allowing NF-¦ÊB to translocate into the nucleus and activate expression of several immune response genes.

Go back
610.0, 866.0
19.0, 19.0

p16

p16

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e18 e32

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c47 : 1
stoichiometry:c49 : 1

m18*m32*0.1

nodelay

--

true

0

false

PMID: 18534908 Upon various stimuli, I¦ÊB is phosphorylated and degraded, thereby allowing NF-¦ÊB to translocate into the nucleus and activate expression of several immune response genes.

Go back
734.0, 889.5
20.5, 20.5

p17

p17

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e31

MO000019479 e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c51 : 1
stoichiometry:c50 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18534908 Upon various stimuli, I¦ÊB is phosphorylated and degraded, thereby allowing NF-¦ÊB to translocate into the nucleus and activate expression of several immune response genes.

Go back
649.0, 1381.0
21.0, 21.0

p18

p18

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c53 : 1
stoichiometry:c52 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18534908 Upon various stimuli, I¦ÊB is phosphorylated and degraded, thereby allowing NF-¦ÊB to translocate into the nucleus and activate expression of several immune response genes. PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes.

Go back
155.0, 347.0
17.0, 17.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016922 e22

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m1837*m23*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the noncanonical NF-¦ÊB activation pathway, which functions downstream of certain TNFR family members such as BAFF-R, CD40 or LT?R.

Go back
1166.0, 154.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000214 MO000016595

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m185*m1589*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is essential for the classical or canonical NF-¦ÊB activation pathway, which functions downstream of tumor necrosis factor receptor (TNFR), IL-1 receptors (IL-1Rs), Toll-like receptors (TLRs) and RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs).

Go back
154.0, 498.0
19.0, 19.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 e25

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m25*m26*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the noncanonical NF-¦ÊB activation pathway, which functions downstream of certain TNFR family members such as BAFF-R, CD40 or LT?R.

Go back
328.0, 140.0
15.0, 15.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e29 e28

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c61 : 1
stoichiometry:c62 : 1

m30*m29*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the noncanonical NF-¦ÊB activation pathway, which functions downstream of certain TNFR family members such as BAFF-R, CD40 or LT?R.

Go back
434.0, 454.0
19.0, 19.0

p22

p22

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 e27

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c69 : 1
stoichiometry:c64 : 1

m33*m28*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the noncanonical NF-¦ÊB activation pathway, which functions downstream of certain TNFR family members such as BAFF-R, CD40 or LT?R.

Go back
479.0, 455.0
17.0, 17.0

p23

p23

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 e23

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c70 : 1
stoichiometry:c66 : 1

m33*m24*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the noncanonical NF-¦ÊB activation pathway, which functions downstream of certain TNFR family members such as BAFF-R, CD40 or LT?R.

Go back
529.0, 449.0
21.0, 21.0

p24

p24

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 e26

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c71 : 1
stoichiometry:c68 : 1

m33*m27*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the noncanonical NF-¦ÊB activation pathway, which functions downstream of certain TNFR family members such as BAFF-R, CD40 or LT?R.

Go back
410.0, 658.0
19.0, 19.0

p25

p25

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e34 e19

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c44 : 1

m34*m19*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required as an IKK¦Á-IKK¦Á homodimer and activates another form of NF-¦ÊB (p100/RelB) by phosphorylating p100.

Go back
343.0, 771.0
17.0, 17.0

p26

p26

cso30:i:ME_Processing

cso30:i:CC_Cytosol

--

e20

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c73 : 1
stoichiometry:c76 : 1

m20*0.1

nodelay

--

true

0

false

PMID: 18534908 This phosphorylation leads to processing of p100 to p52, thereby inducing expression of target chemokine genes.

Go back
574.0, 1110.0
19.0, 19.0

p27

p27

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e35

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c77 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18534908 This phosphorylation leads to processing of p100 to p52, thereby inducing expression of target chemokine genes.

Go back
643.0, 1231.0
25.0, 25.0

p28

p28

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m35*0.1

nodelay

--

true

0

false

PMID: 18534908 This phosphorylation leads to processing of p100 to p52, thereby inducing expression of target chemokine genes.

Go back
789.0, 1288.5
22.5, 22.5

p29

p29

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c81 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes.

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1056.0, 160.0
15.0, 15.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000205 MO000000204

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c8 : 1
stoichiometry:c9 : 1
stoichiometry:c7 : 1

m176*m175*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is essential for the classical or canonical NF-¦ÊB activation pathway, which functions downstream of tumor necrosis factor receptor (TNFR), IL-1 receptors (IL-1Rs), Toll-like receptors (TLRs) and RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs).

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856.0, 1236.0
23.0, 23.0

p30

p30

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearBody

--

e30

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes.

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1370.0, 562.0
19.0, 19.0

p31

p31

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000016882

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 18534908 These TLRs recognize double-stranded RNA (dsRNA) and lipopolysaccharides (LPSs), respectively.

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746.0, 458.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022224 MO000019398

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c88 : 1
stoichiometry:c89 : 1
stoichiometry:c90 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18534908 These TLRs recognize double-stranded RNA (dsRNA) and lipopolysaccharides (LPSs), respectively.

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786.0, 1454.0
19.0, 19.0

p33

p33

cso30:i:ME_DNABinding

cso30:i:CC_Nucleoplasm

--

MO000000210 e45 MO000000204

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c91 : 1
stoichiometry:c92 : 1
stoichiometry:c94 : 1
stoichiometry:c93 : 1

m181*m45*m175*0.1

nodelay

--

true

0

false

PMID: 18534908 In response to TNF, IKK¦Á is recruited to NF-¦ÊB responsive promoters and leads to phosphorylation and subsequent acetylation of histone H3, thereby being involved in NF-¦ÊB?induced gene expression.

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919.0, 1495.0
17.0, 17.0

p34

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e44

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18534908 In response to TNF, IKK¦Á is recruited to NF-¦ÊB responsive promoters and leads to phosphorylation and subsequent acetylation of histone H3, thereby being involved in NF-¦ÊB?induced gene expression.

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730.0, 1498.0
19.0, 19.0

p35

p35

cso30:i:ME_Acetylation

cso30:i:CC_Nucleoplasm

--

e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 18534908 In response to TNF, IKK¦Á is recruited to NF-¦ÊB responsive promoters and leads to phosphorylation and subsequent acetylation of histone H3, thereby being involved in NF-¦ÊB?induced gene expression.

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786.0, 486.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18534908 TLR3 can also associate with TRIF but not with MyD88.

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1443.0, 639.0
17.0, 17.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e43 MO000016573

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1

m43*m1572*0.1

nodelay

--

true

0

false

PMID: 18534908 From fig.2

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1387.0, 755.0
17.0, 17.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e43 MO000041125

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1

m43*m18998*0.1

nodelay

--

true

0

false

PMID: 18534908 From fig.2

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1010.0, 942.0
19.0, 19.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 e49

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m63*m49*0.1

nodelay

--

true

0

false

PMID: 18534908 from fig.2

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1382.0, 362.0
20.0, 20.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000016573

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m6*m1572*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation.

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979.0, 955.0
17.0, 17.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041437 e63

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m19305*m63*0.1

nodelay

--

true

0

false

Go back
943.0, 835.0
17.0, 17.0

p41

p41

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000016608

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1
stoichiometry:c116 : 1

m3902*m1599*0.1

nodelay

--

true

0

false

PMID: 18534908 TBK1 can form heterodimers with IKK epsilon

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1115.0, 1147.0
17.0, 17.0

p42

p42

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e64

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m977*m64*0.1

nodelay

--

true

0

false

PMID: 18534908, 12692549, 12702806 IFN regulatory factor (IRF)-3 is an essential transcription factor for IFN-¦Â (type I interferon) gene induction and is a crucial target for TBK1 and IKKvar epsilon/¦É phosphorylation

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1166.0, 1306.0
19.0, 19.0

p43

p43

cso30:i:ME_Dimerization

cso30:i:CC_Cytosol

--

MO000041456

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18534908 Phosphorylated IRF-3 forms homodimers that are translocated into the nucleus after signaling through TLR3 or TLR4.

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1074.0, 1446.0
19.0, 19.0

p44

p44

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e65

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 18534908 Phosphorylated IRF-3 forms homodimers that are translocated into the nucleus after signaling through TLR3 or TLR4.

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960.0, 1284.0
15.0, 15.0

p45

p45

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c125 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18534908 TRIF links TLR3 and 4 signaling with IRF-3 activation and subsequent IFN-¦Â induction.

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762.0, 342.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 MO000022224

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m41844*m119368*0.1

nodelay

--

true

0

false

PMID: 18534908 In addition to TLR3 and 4, cytosolic viral recognition molecules such as RIG-I or MDA5 can also activate IRF-3 and induce IFN-¦Â.

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730.0, 378.0
19.0, 19.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 MO000022224

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c130 : 1
stoichiometry:c131 : 1

m76904*m119368*0.1

nodelay

--

true

0

false

PMID: 18534908 In addition to TLR3 and 4, cytosolic viral recognition molecules such as RIG-I or MDA5 can also activate IRF-3 and induce IFN-¦Â.

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593.0, 349.0
21.0, 21.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e69 MO000094908

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c132 : 1
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m69*m68199*0.1

nodelay

--

true

0

false

PMID: 18534908, 16713980, 16785313 This pathway is independent of TRIF, but dependent on another cytoplasmic adaptor, called IFN-¦Â promoter stimulator 1 (IPS-1).

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838.0, 434.0
19.0, 19.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e68 MO000094908

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1
stoichiometry:c137 : 1

m68*m68199*0.1

nodelay

--

true

0

false

PMID: 18534908, 16713980, 16785313 This pathway is independent of TRIF, but dependent on another cytoplasmic adaptor, called IFN-¦Â promoter stimulator 1 (IPS-1).

Go back
1365.0, 437.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e6 MO000041125

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m6*m18998*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation.

Go back
921.0, 977.0
21.0, 21.0

p50

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 e70

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c138 : 1
stoichiometry:c140 : 1
stoichiometry:c139 : 1

m63*m70*0.1

nodelay

--

true

0

false

PMID: 18534908 cytosolic viral recognition molecules such as RIG-I or MDA5 can also activate IRF-3 and induce IFN-¦Â. This pathway is independent of TRIF, but dependent on another cytoplasmic adaptor, called IFN-¦Â promoter stimulator 1 (IPS-1)

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1041.0, 881.0
21.0, 21.0

p51

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 e71

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c143 : 1
stoichiometry:c142 : 1

m63*m71*0.1

nodelay

--

true

0

false

PMID: 18534908 cytosolic viral recognition molecules such as RIG-I or MDA5 can also activate IRF-3 and induce IFN-¦Â. This pathway is independent of TRIF, but dependent on another cytoplasmic adaptor, called IFN-¦Â promoter stimulator 1 (IPS-1)

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890.0, 1374.0
19.0, 19.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e66

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18534908 RLRs, but not TLR3 or 4, can induce IFN-¦Á. This IFN-¦Á induction also depends on TBK1 and IKKvar epsilon/¦É.

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1105.0, 1641.0
21.0, 21.0

p53

p53

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e73 MO000061425

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c146 : 1
stoichiometry:c147 : 1
stoichiometry:c148 : 1

m73*m36323*0.1

nodelay

--

true

0

false

PMID: 18534908, 17618271 The cytosolic detector for dsDNA is reported to be Z-DNA binding protein 1 (ZBP1), also known as DNA-dependent activator of IFN-regulatory factors (DAI)

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1094.0, 930.0
19.0, 19.0

p54

p54

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63 e74

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c151 : 1
stoichiometry:c150 : 1

m63*m74*0.1

nodelay

--

true

0

false

PMID: 18534908 Another form of nucleic acid, dsDNA, also induces IFN-¦Á and IFN-¦Â in a TBK1-dependent manner.

Go back
651.0, 955.5
17.5, 17.5

p55

p55

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e64 e106

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c254 : 1
stoichiometry:c153 : 1

m64*m107*0.1

nodelay

--

true

0

false

PMID: 18534908 TBK1/IKKvar epsilon/¦É can also phosphorylate p65, but whether this is crucial for NF-¦ÊB activation is unclear.

Go back
901.0, 1297.0
21.0, 21.0

p56

p56

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e64

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c155 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18534908 double-stranded DNA (dsDNA)-induced signaling through the cytosolic detector system can induce production of IFN-¦Á and IFN-¦Â, which requires TBK1 but not IPS-1.

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950.0, 1406.0
19.0, 19.0

p57

p57

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e64

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c157 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18534908 double-stranded DNA (dsDNA)-induced signaling through the cytosolic detector system can induce production of IFN-¦Á and IFN-¦Â, which requires TBK1 but not IPS-1.

Go back
358.0, 1206.0
19.0, 19.0

p58

p58

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e64

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c265 : 1
stoichiometry:c160 : 1

m980*m64*0.1

nodelay

--

true

0

false

PMID: 18534908, 12702806 IRF-7 can also be phosphorylated and activated by TBK1 and IKKvar epsilon/¦É

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941.0, 145.0
21.0, 21.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e11

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m1572*m11*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation.

Go back
694.0, 1338.0
19.0, 19.0

p60

p60

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e66

G010713

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c165 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18534908,11070172 the IRF-7 gene itself is upregulated by IRF-3 activation and type I IFN signaling

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519.0, 523.0
17.0, 17.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e77

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c167 : 1
stoichiometry:c169 : 1
stoichiometry:c168 : 1

m19940*m77*0.1

nodelay

--

true

0

false

PMID: 18534908 TLR7 and TLR9 respond to single-stranded RNA and CpG DNA, respectively.

Go back
518.0, 630.0
19.0, 19.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e78 MO000042012

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c170 : 1
stoichiometry:c171 : 1
stoichiometry:c172 : 1

m78*m19828*0.1

nodelay

--

true

0

false

PMID: 18534908 TLR7 and TLR9 respond to single-stranded RNA and CpG DNA, respectively.

Go back
625.0, 633.0
21.0, 21.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e79 MO000016573

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c173 : 1
stoichiometry:c174 : 1
stoichiometry:c175 : 1

m79*m1572*0.1

nodelay

--

true

0

false

PMID: 18534908 MyD88 is essential for all effects of TLR7 and TLR9.

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611.0, 555.0
17.0, 17.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e76 MO000016573

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c176 : 1
stoichiometry:c178 : 1
stoichiometry:c177 : 1

m76*m1572*0.1

nodelay

--

true

0

false

PMID: 18534908 MyD88 is essential for all effects of TLR7 and TLR9.

Go back
388.0, 836.0
15.0, 15.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e81

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c179 : 1
stoichiometry:c184 : 1
stoichiometry:c180 : 1

m82*m81*0.1

nodelay

--

true

0

false

Go back
451.0, 827.0
17.0, 17.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e82 e80

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c183 : 1
stoichiometry:c182 : 1

m82*m80*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the TLR7/9-induced MyD88-dependent pathway that leads to expression of IFN-¦Á and IFN-¦Â.

Go back
840.0, 1332.0
23.0, 23.0

p67

p67

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e83

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c185 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the TLR7/9-induced MyD88-dependent pathway that leads to expression of IFN-¦Á and IFN-¦Â.

Go back
974.0, 1210.0
19.0, 19.0

p68

p68

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e83

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c187 : 1

m83*0.1

nodelay

--

true

0

false

PMID: 18534908 IKK¦Á is required for the TLR7/9-induced MyD88-dependent pathway that leads to expression of IFN-¦Á and IFN-¦Â.

Go back
409.0, 1105.0
21.0, 21.0

p69

p69

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e83

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c191 : 1
stoichiometry:c190 : 1

m980*m83*0.1

nodelay

--

true

0

false

PMID: 18534908, 16612387 IRF-7 was found abundantly expressed in pDC and is a target for IKK¦Á.

Go back
863.0, 634.0
15.0, 15.0

p7

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000033291 e14

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m11981*m14*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation. PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes.

Go back
381.0, 1453.0
21.0, 21.0

p70

p70

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041457 MO000000030

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c194 : 1
stoichiometry:c193 : 1

m19325*m85*0.1

nodelay

--

true

0

false

PMID: 18534908, 18227218 phosphatidylinositol-3 kinase (PI3K) is also crucial for nuclear translocation of IRF-7 and type I IFN induction in human pDCs.

Go back
661.0, 1557.0
21.0, 21.0

p71

p71

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e84

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c195 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 18534908, 18227218 phosphatidylinositol-3 kinase (PI3K) is also crucial for nuclear translocation of IRF-7 and type I IFN induction in human pDCs.

Go back
749.0, 1561.0
21.0, 21.0

p72

p72

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e84

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c197 : 1

m84*0.1

nodelay

--

true

0

false

PMID: 18534908, 18227218 phosphatidylinositol-3 kinase (PI3K) is also crucial for nuclear translocation of IRF-7 and type I IFN induction in human pDCs.

Go back
808.0, 1556.0
23.0, 23.0

p73

p73

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000016963

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m1872*0.1

nodelay

--

true

0

false

PMID: 18534908, 16306937, 16306936, 16604075 cytoplasmic adaptors such as TRAF3 and osteopontin are involved in type I IFN induction from pDCs.

Go back
877.0, 1553.0
21.0, 21.0

p74

p74

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

MO000016963

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1

m1872*0.1

nodelay

--

true

0

false

PMID: 18534908, 16306937, 16306936, 16604075 cytoplasmic adaptors such as TRAF3 and osteopontin are involved in type I IFN induction from pDCs.

Go back
964.0, 1500.0
23.0, 23.0

p75

p75

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e85

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c203 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 18534908, 16306937, 16306936, 16604075 cytoplasmic adaptors such as TRAF3 and osteopontin are involved in type I IFN induction from pDCs.

Go back
997.0, 1449.0
21.0, 21.0

p76

p76

cso30:i:ME_GeneExpression

cso30:i:CC_Extracellular

--

e85

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c205 : 1
stoichiometry:c206 : 1

m86*0.1

nodelay

--

true

0

false

PMID: 18534908, 16306937, 16306936, 16604075 cytoplasmic adaptors such as TRAF3 and osteopontin are involved in type I IFN induction from pDCs.

Go back
433.0, 1173.0
21.0, 21.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e86

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c207 : 1
stoichiometry:c209 : 1
stoichiometry:c208 : 1

m980*m87*0.1

nodelay

--

true

0

false

PMID: 18534908, 15767370 Another serine threonine kinase, IRAK-1, was also identified as an IRF-7 kinase and was found to be crucial for TLR7/9-induced type I IFN production in pDCs

Go back
545.0, 877.0
21.0, 21.0

p78

p78

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e87 e80

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c211 : 1

m88*m80*0.1

nodelay

--

true

0

false

PMID: 18534908, 15767370 Another serine threonine kinase, IRAK-1, was also identified as an IRF-7 kinase and was found to be crucial for TLR7/9-induced type I IFN production in pDCs

Go back
501.0, 837.0
21.0, 21.0

p79

p79

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e87 e81

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c215 : 1
stoichiometry:c214 : 1

m88*m81*0.1

nodelay

--

true

0

false

PMID: 18534908, 15767370 Another serine threonine kinase, IRAK-1, was also identified as an IRF-7 kinase and was found to be crucial for TLR7/9-induced type I IFN production in pDCs

Go back
924.0, 607.0
21.0, 21.0

p8

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000033291 e13

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c24 : 1
stoichiometry:c23 : 1

m11981*m13*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation. PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes.

Go back
79.0, 839.0
17.0, 17.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e88 MO000044940

e89

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c217 : 1
stoichiometry:c218 : 1

m89*m22603*0.1

nodelay

--

true

0

false

PMID: 18534908 Necrotic cells release nuclear proteins including HMGB-1, which bind to nucleic acids and facilitate TLR9 signaling.

Go back
124.0, 996.0
15.0, 15.0

p81

p81

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e88 e90

e91

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m89*m91*0.1

nodelay

--

true

0

false

PMID: 18534908 LL37 forms a complex with DNA, and this complex formation facilitates the incorporation of DNA by pDCs and its retention in the early endosome, thereby activating the pDCs to produce IFN-¦Á via TLR9

Go back
353.0, 961.0
21.0, 21.0

p82

p82

cso30:i:ME_Internalization

cso30:i:CC_Cytosol

--

e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c223 : 1

m92*0.1

nodelay

--

true

0

false

PMID: 18534908 LL37 forms a complex with DNA, and this complex formation facilitates the incorporation of DNA by pDCs and its retention in the early endosome, thereby activating the pDCs to produce IFN-¦Á via TLR9

Go back
705.0, 1221.0
21.0, 21.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e30

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c224 : 1

m21*0.1

nodelay

--

true

0

false

PMID: 18534908 I¦ÊB¦Á is resynthesized in an NF-¦ÊB?dependent manner, enters the nucleus and transports nuclear NF-¦ÊB back out to the cytoplasm, thereby downregulating NF-¦ÊB?mediated transcription

Go back
796.0, 1016.0
23.0, 23.0

p84

p84

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e93

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c227 : 1

m94*0.1

nodelay

--

true

0

false

PMID: 18534908 I¦ÊB¦Á is resynthesized in an NF-¦ÊB?dependent manner, enters the nucleus and transports nuclear NF-¦ÊB back out to the cytoplasm, thereby downregulating NF-¦ÊB?mediated transcription

Go back
705.0, 1401.0
21.0, 21.0

p85

p85

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e30 e94

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m21*m95*0.1

nodelay

--

true

0

false

PMID: 18534908 NF-¦ÊB is shuttled back to the cytoplasm in a process mediated by I¦ÊB¦Á, which is resynthesized in an NF-¦ÊB?dependent manner after its initial degradation by I¦ÊB kinase (IKK).

Go back
481.0, 1572.0
19.0, 19.0

p86

p86

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e95

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1
stoichiometry:c232 : 1

m96*0.1

nodelay

--

true

0

false

PMID: 18534908 NF-¦ÊB is shuttled back to the cytoplasm in a process mediated by I¦ÊB¦Á, which is resynthesized in an NF-¦ÊB?dependent manner after its initial degradation by I¦ÊB kinase (IKK).

Go back
1022.0, 1322.0
19.0, 19.0

p87

p87

cso30:i:ME_Ubiquitination

cso30:i:CC_Nucleoplasm

--

e66

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18534908, 9566918, 17015689 when cells are infected with Sendai virus, IRF3 is polyubiquitinated in the nucleus.

Go back
479.0, 1275.0
17.0, 17.0

p88

p88

cso30:i:ME_Ubiquitination

cso30:i:CC_Extracellular

--

e84 e98

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c235 : 1
stoichiometry:c237 : 1
stoichiometry:c236 : 1

m84*m99*0.1

nodelay

--

true

0

false

PMID: 18534908, 15664159 Kaposi's sarcoma-associated herpes virus (KSHV)-encoded RTA protein acts as a nuclear ubiquitin E3 ligase for IRF7, promoting its polyubiquitination and degradation

Go back
513.0, 1181.0
21.0, 21.0

p89

p89

cso30:i:ME_UnknownDegradation

cso30:i:CC_Nucleoplasm

--

e97

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c239 : 1

m98*0.1

nodelay

--

true

0

false

PMID: 18534908, 15664159 Kaposi's sarcoma-associated herpes virus (KSHV)-encoded RTA protein acts as a nuclear ubiquitin E3 ligase for IRF7, promoting its polyubiquitination and degradation

Go back
824.0, 639.0
21.0, 21.0

p9

p9

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000033291 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c27 : 1
stoichiometry:c26 : 1

m11981*m15*0.1

nodelay

--

true

0

false

PMID: 18534908 Two TLR adapters, MyD88 and TRIF, can lead to IKK¦Â activation. PMID: 18534908 IKK¦Â is required as an IKK¦Á-IKK¦Â heterodimer or as an IKK¦Â-IKK¦Â homodimer and induces NF-¦ÊB activation by phosphorylating I¦ÊB, thereby inducing expression of proinflammatory cytokine genes

Go back
1165.0, 1145.0
21.0, 21.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041456 MO000017197

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c240 : 1
stoichiometry:c241 : 1
stoichiometry:c242 : 1

m19324*m2065*0.1

nodelay

--

true

0

false

PMID: 18534908, 16699525 The prolyl isomerase, Pin1, also interacts with phosphorylated IRF-3 and facilitates its polyubiquitination.

Go back
1206.0, 1010.0
19.0, 19.0

p91

p91

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e100

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c244 : 1

m101*0.1

nodelay

--

true

0

false

PMID: 18534908, 16699525 The prolyl isomerase, Pin1, also interacts with phosphorylated IRF-3 and facilitates its polyubiquitination.

Go back
649.0, 1189.0
21.0, 21.0

p92

p92

cso30:i:ME_Binding

cso30:i:CC_Nucleoplasm

--

e30 e101

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c245 : 1
stoichiometry:c246 : 1
stoichiometry:c247 : 1

m21*m102*0.1

nodelay

--

true

0

false

PMID: 18534908 The p65 NF-¦ÊB subunit binds to a nuclear protein, PDLIM2, and is ubiquitinated.

Go back
765.0, 1165.0
21.0, 21.0

p93

p93

cso30:i:ME_Ubiquitination

cso30:i:CC_Extracellular

--

e103

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c248 : 1
stoichiometry:c249 : 1

m104*0.1

nodelay

--

true

0

false

PMID: 18534908 The p65 NF-¦ÊB subunit binds to a nuclear protein, PDLIM2, and is ubiquitinated.

Go back
819.0, 1147.0
17.0, 17.0

p94

p94

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Nucleoplasm

--

e104

e99 e101 e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c251 : 1
stoichiometry:c252 : 1
stoichiometry:c253 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 18534908 It is targeted to discrete nuclear regions, the promyelocytic leukemia protein nuclear bodies, and degraded in a proteasome-dependent manner.

Go back
1158.0, 646.0
19.0, 19.0

p95

p95

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e17 e48

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c262 : 1
stoichiometry:c264 : 1
stoichiometry:c263 : 1

m17*m48*0.1

nodelay

--

true

0

false

PMID: 18534908 From fig.2

Go back
722.0, 1014.0
20.0, 20.0

p96

p96

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e75

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c255 : 1

m75*0.1

nodelay

--

true

0

false

PMID: 18534908 Upon various stimuli, I¦ÊB is phosphorylated and degraded, thereby allowing NF-¦ÊB to translocate into the nucleus and activate expression of several immune response genes.

Go back
443.0, 1039.0
17.0, 17.0

p97

p97

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e75 e107

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c256 : 1
stoichiometry:c257 : 1
stoichiometry:c258 : 1

m75*m108*0.1

nodelay

--

true

0

false

PMID: 18534908, 14690596, 17183367 The multimeric ubiquitin ligase complex, ECS, which is composed of Elongins B and C, Cullin2 and SOCS1, is also reported to mediate p65 polyubiquitination and subsequent degradation.

Go back
390.0, 1010.0
19.0, 19.0

p98

p98

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e108

MO000019479 e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c259 : 1
stoichiometry:c260 : 1
stoichiometry:c261 : 1

m109*0.1

nodelay

--

true

0

false

PMID: 18534908, 14690596, 17183367 The multimeric ubiquitin ligase complex, ECS, which is composed of Elongins B and C, Cullin2 and SOCS1, is also reported to mediate p65 polyubiquitination and subsequent degradation.

Go back
1303.0, 348.0

c1

c1

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1295.0, 350.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.9498775178084, 449.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.288244344552, 505.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.0, 648.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.0, 381.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1296.3531602401445, 652.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1286.0, 658.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1229.0, 457.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1298.6582051289422, 767.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
994.0, 893.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1025.0, 961.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1111.0, 372.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1035.883291819427, 809.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
748.0, 573.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
988.0, 893.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
996.0, 971.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
879.0, 844.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
967.3365604500259, 820.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 852.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.8374782761443, 1090.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.0, 1164.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1068.0, 1040.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1303.5259830722491, 376.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 1238.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.0, 1325.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1011.7829814889137, 1386.527849952638

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1101.0, 1456.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.4022870018616, 1306.6307940059135

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
936.9281045069552, 1235.96921767363

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
788.9016978127913, 326.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.5538553641524, 362.5876987549066

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
781.0, 354.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.0, 351.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1295.0, 360.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 388.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
681.0, 388.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
621.2888633827068, 368.29734295884356

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
621.1057411452476, 340.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.1117964514128, 365.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.4437601569801, 380.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
677.0, 342.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
857.0, 403.8161052203985

c137

c137

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
941.6453688709789, 893.0

c138

c138

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.0, 991.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1233.0, 448.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
558.0, 404.0

c140

c140

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1000.0, 882.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1053.0, 902.0

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
904.0, 402.0

c143

c143

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
916.8849780385061, 1370.0

c144

c144

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
869.428457546758, 1392.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1041.0, 1652.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1134.0, 1652.0

c147

c147

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1116.0, 1588.0

c148

c148

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.0, 886.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1306.1554175279994, 454.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1072.6259734110108, 949.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1104.16050280467, 956.9983897660525

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
560.0, 942.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
567.7561004513301, 940.9603330811054

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
676.9096295916166, 966.1990661880908

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
914.0, 1236.8782684705434

c155

c155

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
921.6986413211023, 1040.0

c156

c156

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
877.9844206278631, 1417.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
964.9701784257642, 1040.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
368.0, 1181.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
963.5077462216557, 172.60910160317943

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 1225.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
522.8513208661648, 1350.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
720.9817461979922, 1349.540118163774

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
541.8421713081511, 496.0

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 534.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 547.253768895108

c169

c169

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
969.3513041378435, 163.15568177624502

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
528.4376995736171, 656.9880172185127

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.3257896609113, 651.8973855439314

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
537.0, 637.5150582239837

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.0, 637.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.8994740725439, 378.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
631.1005469701975, 654.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
588.0, 548.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.2469504755443, 571.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
635.4244767547447, 376.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.10445600046506, 779.0

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 166.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
400.0, 851.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.0, 779.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
444.8255305823146, 844.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.2876365146944, 712.0

c183

c183

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
406.7865534827817, 607.0

c184

c184

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
849.4204706649821, 1355.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 931.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
953.0, 1220.0

c187

c187

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.0, 926.0

c188

c188

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 1131.4057970281387

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
875.4022870018616, 580.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
376.54815230697517, 1126.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
421.823193208684, 931.0

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
375.0, 1376.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
402.0, 1346.121475197316

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
397.5298221281347, 1481.5894663844042

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
682.0, 1441.077042199227

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
564.0, 1344.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
765.0, 1236.2152338338256

c197

c197

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
569.0, 1344.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
579.0, 1577.3865486632396

c199

c199

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1356.0, 272.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
871.0, 649.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 1443.8446454055274

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.0, 1570.858386482081

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
889.0, 1236.9455391136191

c202

c202

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.5942782824095, 1440.5294032646852

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 1530.7727218904142

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
937.0, 1477.6074696756514

c205

c205

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
933.5194658048299, 1236.5929106446931

c206

c206

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.0, 1168.0

c207

c207

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
382.0136665432816, 1194.0

c208

c208

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
447.51812287804336, 935.0

c209

c209

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.5330827562383, 496.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
556.0, 827.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
513.4013489469979, 892.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.9063553271329, 718.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
527.6568542494924, 814.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.94028500029066, 858.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
517.1532952431061, 608.0

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
72.0, 863.820654249389

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
88.0, 737.0

c217

c217

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
96.0, 845.4204706649821

c218

c218

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
75.0, 935.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 580.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
76.0, 1016.6568542494924

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
132.0, 1011.0

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
147.0, 982.0517700340185

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
370.0, 501.92849437507255

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
716.0, 1242.0

c224

c224

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 1238.7410427608056

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
720.0, 1046.5027871695181

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
818.0, 1039.0

c227

c227

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 1287.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
728.7874335579578, 1156.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
882.1808595010745, 628.0

c23

c23

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.4345852499463, 1416.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
499.72222921664894, 1494.0

c231

c231

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.0, 783.9046634311254

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1006.0, 1346.268036862948

c233

c233

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.1005469701975, 1293.923938185422

c234

c234

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
502.67966563693466, 1293.4025068970707

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
488.0, 1260.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.0, 1298.9329796549935

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
497.0, 1208.3692975529848

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 1116.091551598562

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
951.8895085152125, 419.0

c24

c24

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1176.0, 1174.0

c240

c240

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1193.982281262853, 1153.0

c241

c241

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1176.0, 1108.0

c242

c242

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1183.0, 1035.87281235127

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1189.2612067229911, 961.3051030595001

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
619.0, 1216.4334091317305

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
665.2667691281392, 1145.0

c246

c246

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
670.0, 1182.7898696961713

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
736.0, 1176.0

c248

c248

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
783.0, 1186.0

c249

c249

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
847.4892664309411, 580.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
812.0, 1171.6388542106463

c250

c250

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.2560717419874, 1116.368890451637

c251

c251

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.8895176356772, 1134.32495716019

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
828.0, 1113.0

c253

c253

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
665.3526867907002, 917.0

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.5777087639997, 1034.0

c255

c255

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
465.20076648753627, 949.0

c256

c256

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
462.4920113466981, 1062.619806195134

c257

c257

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
383.63380971140487, 1051.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
373.0, 1035.6883832866965

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
838.0, 660.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
409.0, 905.1926878371034

c260

c260

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.0, 989.9796695986458

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1047.0, 630.0

c262

c262

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.2063309876478, 665.0

c263

c263

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1183.797121329585, 666.2189028942252

c264

c264

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
384.7068194971045, 1028.0

c265

c265

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.2462724791444, 263.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
798.2828443809673, 576.0

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.0, 659.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1302.0, 291.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
793.3842100584869, 265.0

c30

c30

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1043.0, 642.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1068.0, 699.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1078.894393608129, 428.0

c33

c33

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1017.4832142536907, 642.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.0, 708.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.3940471355468, 500.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
984.0285524572718, 638.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.0, 696.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
971.3682894312905, 268.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1176.0, 115.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1047.0, 635.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1078.2573723617468, 693.0

c41

c41

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.0, 263.0

c42

c42

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
627.0, 776.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
373.0, 668.0

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
664.7421951148484, 771.0

c45

c45

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
657.0, 824.0

c46

c46

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 776.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
636.7939115054407, 774.0

c48

c48

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.0, 832.0567213159391

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1185.100879340429, 179.86897289521832

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 900.0

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
755.0, 900.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.0, 1339.8632840217354

c52

c52

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
614.0, 1287.0

c53

c53

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
180.0, 356.0

c54

c54

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
126.0, 290.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
172.0, 360.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
181.0, 508.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
102.0, 508.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
173.0, 514.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1176.0, 173.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
346.89497719930716, 87.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
341.7509280956508, 162.5121497996618

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.7911800874873, 155.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
449.079787787583, 402.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
446.0, 473.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
467.0, 402.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.9469149448716, 472.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 399.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.7999954687553, 470.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
322.0, 264.0

c69

c69

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1049.789539285751, 175.0

c7

c7

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
298.0, 415.0

c70

c70

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
295.0, 469.5777087639997

c71

c71

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.0, 840.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.0, 683.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
425.3430000067613, 547.0

c74

c74

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
437.0, 668.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
352.0, 788.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
584.0, 1129.0

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
367.0, 903.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
367.0, 905.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1070.1243987748494, 182.36465425500205

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.0, 1256.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.0, 1311.0

c81

c81

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
620.0, 1274.0

c82

c82

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0, 1249.7425433283772

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
863.0573097607281, 1259.0

c84

c84

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1289.0, 572.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1397.0, 572.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1292.436592636686, 579.0

c87

c87

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.1530859662622, 401.0

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
716.0, 468.0

c89

c89

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1064.0, 93.0

c9

c9

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
738.6499055497528, 477.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.0, 1411.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.0, 1464.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
805.0, 1464.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
799.5234047364962, 93.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.0, 1473.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
885.9904988089992, 1505.0

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
757.0, 1508.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.0, 1508.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 499.78700925063515

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back