1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18573338.csml convertedTime:2009.07.01.11:20

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Intracellular DNA sensors in immunity.
Authors Takeshita F, Ishii KJ.
Affiliation Department of Molecular Biodefense Research, Yokohama City University GraduateSchool of Medicine, 3-9 Fukuura, Kanazawaku, Yokohama, Japan.takesita@yokohama-cu.ac.jp
Abstract Mammalian innate immunity possesses a distinct system to recognize aberrant DNAinside the cell. One class of DNA sensors is the Toll-like receptor 9, which isexpressed in the specialized immune cells, binds to single-stranded DNA in theendosome to transmit cellular signaling through myeloid differentiation primaryresponse protein 88 (MyD88). Another class of DNA sensors exists in thecytoplasm of most type of cells in the tissue, detecting double-stranded DNA tosignal through TANK-binding kinase-1 (TBK1)-mediated type-I interferonproduction and apoptosis-associated speck-like protein containing a CARD(ASC)-mediated IL-1beta secretion. Since DNA sensors have potential to recognizeaberrant DNA of both self and nonself origin, their physiological roles inmicrobial infection, tissue damage, autoimmune diseases, and DNA-basedtherapeutic applications are being intensively investigated.
PMID 18573338
Model Abstract

Entity

G010389:IL-1beta G010514:iNOS MO000000058:NF-kappaB MO000000210:IKK-alpha MO000000212:TRAF6 MO000007330:proIL-18 MO000007685:IRF-1 MO000007694:IRF-3 MO000007700:IRF-5 MO000007702:IRF-7 MO000016573:MyD88 MO000016597:IL-1beta MO000016625:IL-18 MO000016828:Caspase-1 MO000016894:MAPK MO000016963:TRAF3 MO000019331:TBK1 MO000019449:proIL-1beta MO000022224:dsRNA MO000039077:IRAK-4 MO000041457:IRF-7{p} MO000042012:TLR9 MO000044940:HMGB1 MO000061425:ZBP1 e1: e10:LL37 e11:CpG DNA:TLR9:MYD88 e12:CpG DNA:TLR9:MYD88:IRAK4 e13:IRAK1 e14:CpG DNA:TLR9:MYD88:IRAK4:IRAK1 e15:CpG DNA:TLR9:MYD88:IRAK4:IRAK1:TRAF6 e16:IRF-7{p}{ub} e17:IFN-alpha e18:IFN-alpha e19:IKK-alpha{active} e2: e20:CpG DNA:TLR9:MYD88:TRAF3 e21:NF-kappaB{active} e22:MAPK e23:type I interferon e24:type I interferon e25:TBK1{active} e26:IRF-5{active} e27:IkBzeta e28:IKB-zeta e29:CpG DNA:TLR9:MYD88:IRF1 e3: e30:IRF-1 e31:IFN-beta e32:IL12-p35 e33:UNC93B1 e34:TLR9:UNC93B1 e35:CpG DNA e36:CpG DNA:HMGB1 e37:RAGEs receptor e38:CpG DNA:HMGB1:RAGEs receptor e39:PDC-TREM e4: e40:plexin A1 e41:DAP12 e42:PDC-TREM:plexin A1:DAP12 e43:PDC-TREM e44:self DNA:LL37 e45:self DNA e46:RIG-I e47:dsRNA:RIG-I e48:B-DNA e49:B-DNA:ZBP1 e5:CpG DNA:TLR9 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e60: e61: e62: e63:ZBP1:TBK1 e64:ZBP1:IRF3 e65:ZBP1 oligomer e66:Caspase-1{active} e67:ASC e68:pyrin e69:ASC:pyrin e7: e70:IL-18 e71:IL-33 e72:proIL-33 e73:IL-33 e74:self DNA:Ig complex e75:FcgammaRIIA e76:self DNA:Ig complex:FcgammaRIIa e77:FcgammaRIII e78:self DNA:Ig complex:FcgammaRIII e79:self DNA:Ig complex:TLR9 e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p6 p7 p8 p9
Model Detail
720.0, 1536.0
32.0, 32.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p40

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
895.0, 1247.0
34.0, 34.0

iNOS

--

G010514

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p23

--

true true true true

csml-variable:Double

m93479

10

false

infinite

0

unit false false false
TRANSFACG010514

--

Go back
882.0, 998.0
28.0, 28.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13

true true true true

csml-variable:Double

m21

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
771.0, 727.0
26.0, 26.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
1267.0, 863.0
34.0, 34.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
501.0, 1613.0
29.0, 29.0

proIL-18

--

MO000007330

cso30:c:Protein

cso30:i:CC_CellComponent

--

p43

p42

true true true true

csml-variable:Double

m841

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000007330

--

Go back
613.0, 565.0
30.0, 30.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p20

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
727.0, 431.0
26.0, 26.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
670.0, 1054.0
28.0, 28.0

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
1262.0, 938.0
28.0, 28.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p11 p17

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1252.0, 644.0
24.0, 24.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
266.0, 1362.0
44.0, 44.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
262.0, 1582.0
36.0, 36.0

IL-18

--

MO000016625

cso30:c:Protein

cso30:i:CC_CellComponent

--

p42

--

true true true true

csml-variable:Double

m1611

10

false

infinite

0

unit false false false
InterProIPR008996
TRANSPATHMO000016625

--

Go back
473.0, 797.0
30.0, 30.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
660.0, 912.0
32.0, 32.0

MAPK

--

MO000016894

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14

true true true true

csml-variable:Double

m1812

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
808.0, 608.0
32.0, 32.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
626.0, 678.0
28.0, 28.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p35

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
472.0, 1480.0
32.0, 32.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40

p41

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
1257.0, 361.0
30.0, 30.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1239.0, 699.0
34.0, 34.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
1115.0, 1031.0
26.0, 26.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6 p11 p17

p7

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
1055.0, 611.0
34.0, 34.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1 p25 p48 p49

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
848.0, 44.0
32.0, 32.0

HMGB1

--

MO000044940

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p26

true true true true

csml-variable:Double

m22603

10

false

infinite

0

unit false false false
TRANSPATHMO000044940

--

Go back
856.0, 408.0
32.0, 32.0

ZBP1

--

MO000061425

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p35 p36 p37

true true true true

csml-variable:Double

m36323

10

false

infinite

0

unit false false false
TRANSPATHMO000061425

--

Go back
334.60333785569924, 253.08879800476842
1067.435373591612, 1549.9161624550197

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
1010.0, 164.76894293732454
20.466791393826004, 47.2310570626754

LL37

--

e10

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p32

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false false false

--

Go back
1124.5, 720.3207928060197
22.70343182235273, 31.679207193980552

CpG DNA:TLR9:MYD88

--

e11

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p2 p21

p3 p12 p20

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
1137.0, 750.9999999999999
21.0, 35.00000000000001

CpG DNA:TLR9:MYD88:IRAK4

--

e12

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p3

p4

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
1259.0, 766.8199999999998
34.24, 25.68

IRAK1

--

e13

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p4

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
1135.0, 794.9411764705882
25.23529411764706, 42.05882352941176

CpG DNA:TLR9:MYD88:IRAK4:IRAK1

--

e14

cso30:c:Complex

cso30:i:CC_Cytosol

--

p4

p5 p6

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
1115.0, 849.7352941176471
26.558823529411768, 44.26470588235294

CpG DNA:TLR9:MYD88:IRAK4:IRAK1:TRAF6

--

e15

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p7 p10 p14

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
1255.0, 1092.4534639608119
41.14765570328901, 31.54653603918824

IRF-7{p}{ub}

--

e16

cso30:c:Protein

cso30:i:CC_Cytosol

--

p7

p9

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
987.0, 1302.840830449827
49.048442906574394, 26.15916955017301

IFN-alpha

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p9

p8 p28 p31

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
1277.0, 1304.0147917085933
38.08412155363252, 23.48520829140672

IFN-alpha

--

e18

cso30:c:Protein

cso30:i:CC_Cytosol

--

p8 p28 p31

--

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
811.0, 907.0
26.0, 26.0

IKK-alpha{active}

--

e19

cso30:c:Protein

cso30:i:CC_CellComponent

--

p10

p11 p13

true true true true

csml-variable:Double

m19

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
334.60333785569924, 253.08879800476842
1067.435373591612, 1549.9161624550197

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
942.0, 777.5588235294117
27.264705882352942, 45.44117647058824

CpG DNA:TLR9:MYD88:TRAF3

--

e20

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

p15 p16

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
834.0, 1090.0
28.0, 28.0

NF-kappaB{active}

--

e21

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13

--

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
620.0, 1056.0
32.0, 32.0

MAPK

--

e22

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14

--

true true true true

csml-variable:Double

m23

10

false

infinite

0

unit false false false
TRANSPATHMO000016894

--

Go back
670.0, 1326.5951557093426
36.3840830449827, 19.404844290657444

type I interferon

--

e23

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p15

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
431.0, 1270.978484565014
18.642656688493922, 43.021515434985965

type I interferon

--

e24

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p15

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
630.0, 806.0
28.0, 28.0

TBK1{active}

--

e25

cso30:c:Protein

cso30:i:CC_CellComponent

--

p16

p17

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
614.0, 1122.0
28.0, 28.0

IRF-5{active}

--

e26

cso30:c:Protein

cso30:i:CC_CellComponent

--

p18

p19

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
826.0, 1400.8166089965398
50.96885813148789, 27.18339100346021

IkBzeta

--

e27

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p19

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
491.5, 1139.5250553431274
24.959549205071447, 40.47494465687261

IKB-zeta

--

e28

cso30:c:Protein

cso30:i:CC_Nucleoplasm

--

p19

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
935.0, 721.8823529411765
26.470588235294112, 44.11764705882353

CpG DNA:TLR9:MYD88:IRF1

--

e29

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p20

p21

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
355.9520453275313, 274.4375054766005
1024.737958647948, 1507.2187475113558

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
765.0, 1201.0
30.0, 30.0

IRF-1

--

e30

cso30:c:Protein

cso30:i:CC_CellComponent

--

p21

p22 p23 p24

true true true true

csml-variable:Double

m31

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
978.0, 1444.3598615916956
44.325259515570934, 23.640138408304498

IFN-beta

--

e31

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p22

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
864.0, 1499.006920415225
48.73702422145329, 25.993079584775085

IL12-p35

--

e32

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p24

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
970.0, 498.5746629100422
43.66270879452606, 26.92533708995774

UNC93B1

--

e33

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p25

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
926.5, 619.8353607732045
26.267788701883024, 32.16463922679554

TLR9:UNC93B1

--

e34

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p25

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
650.0, 101.5
60.0, 13.0

CpG DNA

--

e35

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p1 p26 p30

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
803.5, 116.04515914014331
25.279786702216295, 30.954840859856695

CpG DNA:HMGB1

--

e36

cso30:c:Complex

cso30:i:CC_Extracellular

--

p26

p27

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
689.5, 269.46572934973636
28.947275922671352, 44.53427065026362

RAGEs receptor

--

e37

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p27

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
759.5, 270.34575151403925
25.552211414938522, 35.65424848596073

CpG DNA:HMGB1:RAGEs receptor

--

e38

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p27

p28

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
358.5, 359.82425307557105
26.11423550087874, 40.17574692442882

PDC-TREM

--

e39

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p30

p29

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
395.44715415042094, 311.7977435523069
945.7477410021686, 1432.498271359943

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
360.5, 428.7082601054481
30.089630931458696, 46.291739894551846

plexin A1

--

e40

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p29

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
441.0, 388.461561682431
37.35962970416582, 23.03843831756893

DAP12

--

e41

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p29

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
353.5, 516.436777390347
28.353642870251427, 39.56322260965315

PDC-TREM:plexin A1:DAP12

--

e42

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p29

p31

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
699.0, 1452.2179930795849
42.71626297577855, 22.782006920415228

PDC-TREM

--

e43

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p30

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
969.0, 99.73480662983434
29.038674033149174, 32.26519337016575

self DNA:LL37

--

e44

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p32

--

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
876.0, 98.46232422393211
55.55850358185195, 12.037675776067923

self DNA

--

e45

cso30:c:Dna

cso30:i:CC_Cytoplasm

--

--

p32

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
1153.0, 472.22328436305094
37.746025357214734, 23.27671563694908

RIG-I

--

e46

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p33

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
1141.5, 415.1043159473421
21.14814197633728, 25.89568405265789

dsRNA:RIG-I

--

e47

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p33

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
914.0, 357.5
60.0, 13.0

B-DNA

--

e48

cso30:c:Dna

cso30:i:CC_Cytoplasm

--

--

p34 p37 p40 p43 p44

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
890.5, 471.9153474420929
26.202466255624053, 32.08465255790701

B-DNA:ZBP1

--

e49

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p34

--

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
1100.5, 653.53606665205
22.97303222977417, 44.46393334795001

CpG DNA:TLR9

--

e5

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p1

p2 p18

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
593.5543223577433, 1144.9235815984202
580.4915419046745, 526.442050107219

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
656.2517328427921, 1157.3994928596007
339.43080848802214, 510.2272025679824

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
601.1212512093871, 1151.95001553209
565.3576842013872, 512.3891822398805

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
602.2022410453365, 1153.0310053680387
563.1957045294888, 510.2272025679824

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
593.5543223577433, 1144.9235815984202
580.4915419046745, 526.442050107219

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
593.5543223577433, 1144.9235815984202
580.4915419046745, 526.442050107219

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
602.2022410453365, 1153.0310053680387
563.1957045294888, 510.2272025679824

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1017.3023380497959, 1361.121548788242
36.26592202506221, 32.83020309637214

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
922.1752324862746, 1512.4601258211187
102.69403441516583, 92.96512589162391

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
593.5543223577433, 1144.9235815984202
580.4915419046745, 526.442050107219

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
730.3729125835863, 1378.8700786395968
18.38331418939661, 8.85122535045023

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
729.7590416873315, 1352.4736301006496
62.92176686609468, 113.25918035897035

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
756.1554902262791, 1426.1381376511986
9.821934340073302, 9.8219343400733

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
648.0, 526.3204419889504
24.911602209944753, 27.67955801104973

ZBP1:TBK1

--

e63

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p35

--

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
637.0, 487.8563535911603
21.729281767955804, 24.143646408839786

ZBP1:IRF3

--

e64

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p36

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
663.0, 361.33149171270725
26.701657458563542, 29.668508287292813

ZBP1 oligomer

--

e65

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p37

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
453.0, 921.0
30.0, 30.0

Caspase-1{active}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

p41 p42 p45

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
514.0, 536.9753471523445
36.52646407727913, 22.52465284765546

ASC

--

e67

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p38

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
454.0, 473.9799999999999
27.359999999999996, 20.52

pyrin

--

e68

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p38

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
442.0, 631.9558011049725
28.839779005524864, 32.04419889502762

ASC:pyrin

--

e69

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p38

p39

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
348.62788172134344, 256.3257831683225
1046.8215434217843, 1483.3190873578053

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
803.0, 1594.0380622837372
50.55363321799308, 26.961937716262977

IL-18

--

e70

cso30:c:mRNA

cso30:i:CC_Cytoplasm

--

--

p43

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1022.0, 1548.0
60.0, 32.0

IL-33

--

e71

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p44

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
684.5, 1669.1936003219967
23.313946468102237, 37.80639967800363

proIL-33

--

e72

cso30:c:Protein

cso30:i:CC_Cell_WithoutCellWall_

--

p44

p45

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
250.0, 1671.4999999999998
43.99999999999999, 33.00000000000001

IL-33

--

e73

cso30:c:Protein

cso30:i:CC_Extracellular

--

p45

--

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1123.0, 134.04419889502762
25.160220994475136, 27.955801104972373

self DNA:Ig complex

--

e74

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p46 p47

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1051.5, 288.1757469244288
25.88576449912127, 39.82425307557117

FcgammaRIIA

--

e75

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p49

p46

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1109.5, 251.61993026243346
29.655716645256007, 41.38006973756652

self DNA:Ig complex:FcgammaRIIa

--

e76

cso30:c:Complex

cso30:i:CC_Extracellular

--

p46

p49

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1211.5, 280.4059753954306
25.08611599297012, 38.59402460456942

FcgammaRIII

--

e77

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p48

p47

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1282.5, 261.3307028812626
26.996329601761794, 37.66929711873738

self DNA:Ig complex:FcgammaRIII

--

e78

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p47

p48

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
973.5, 588.6139004604253
20.34948476211357, 39.38609953957465

self DNA:Ig complex:TLR9

--

e79

cso30:c:Complex

cso30:i:CC_Cytoplasm

--

p48 p49

--

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
352.3677600855152, 282.5049317175248
1004.2283802896477, 1458.1396081805694

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
372.34076905663994, 260.6840802667271
999.6435268798208, 1439.0164725960065

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
1142.0, 622.5
19.5, 19.5

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e35

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c3 : 1
stoichiometry:c2 : 1

m19828*m36*0.1

nodelay

--

true

0

false

PMID: 18573338, 17572678 Its homodimerized form binds endocytosed CpG DNA through its ectodomain.

Go back
837.0, 841.0
21.0, 21.0

p10

p10

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000000210 e15

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c26 : 1
stoichiometry:c28 : 1
stoichiometry:c27 : 1

m181*m15*0.1

nodelay

--

true

0

false

PMID: 18573338, 18262306 CpG-A activates kinases, such as IRAK1 and I¦ÊB kinase-¦Á (IKK-¦Á), and an E3 ligase, TRAF6, resulting in phosphorylation and ubiquitination of IRF-7, and robust production of IFN-¦Á.

Go back
1207.0, 979.0
17.0, 17.0

p11

p11

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e19

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c31 : 1
stoichiometry:c30 : 1

m980*m19*0.1

nodelay

--

true

0

false

PMID: 18573338, 18262306 CpG-A activates kinases, such as IRAK1 and I¦ÊB kinase-¦Á (IKK-¦Á), and an E3 ligase, TRAF6, resulting in phosphorylation and ubiquitination of IRF-7, and robust production of IFN-¦Á.

Go back
893.0, 661.0
21.0, 21.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016963 e11

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1
stoichiometry:c34 : 1

m1872*m11*0.1

nodelay

--

true

0

false

PMID: 18573338 CpG-A-induces TRAF3 recruitment to the complex consisting of activated (=dimerized) MyD88, triggering type-I IFN production in pDCs.

Go back
841.0, 1013.0
21.0, 21.0

p13

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e19

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c37 : 1
stoichiometry:c36 : 1

m21*m19*0.1

nodelay

--

true

0

false

PMID: 18573338 CpG-B elicits activation of mitogen-activated protein (MAP) kinases and NF-¦ÊB through TRAF6, which is pivotal for proinflammatory cytokine and chemokine gene expression.

Go back
665.0, 1009.0
21.0, 21.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016894 e15

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c38 : 1
stoichiometry:c40 : 1
stoichiometry:c39 : 1

m1812*m15*0.1

nodelay

--

true

0

false

PMID: 18573338 CpG-B elicits activation of mitogen-activated protein (MAP) kinases and NF-¦ÊB through TRAF6, which is pivotal for proinflammatory cytokine and chemokine gene expression.

Go back
578.0, 1214.0
19.0, 19.0

p15

p15

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e23 e20

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c41 : 1
stoichiometry:c43 : 1
stoichiometry:c42 : 1

m24*m20*0.1

nodelay

--

true

0

false

PMID: 18573338 CpG-A-induces TRAF3 recruitment to the complex consisting of activated (=dimerized) MyD88, triggering type-I IFN production in pDCs.

Go back
579.0, 743.0
17.0, 17.0

p16

p16

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e20

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c46 : 1
stoichiometry:c45 : 1

m3902*m20*0.1

nodelay

--

true

0

false

PMID: 18573338 In cDCs and macrophages, TRAF3 coordinates TANK-binding kinase-1 (TBK1)-mediated phosphorylation of IRF-7 for type-I IFN production, while TRAF6 mediates NF-¦ÊB activation to induce proinflammatory cytokine production.

Go back
1257.0, 1025.0
21.0, 21.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytoplasm

--

MO000007702 e25

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c47 : 1
stoichiometry:c49 : 1
stoichiometry:c48 : 1

m980*m26*0.1

nodelay

--

true

0

false

PMID: 18573338 In cDCs and macrophages, TRAF3 coordinates TANK-binding kinase-1 (TBK1)-mediated phosphorylation of IRF-7 for type-I IFN production, while TRAF6 mediates NF-¦ÊB activation to induce proinflammatory cytokine production.

Go back
721.0, 1109.0
21.0, 21.0

p18

p18

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000007700 e5

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c50 : 1
stoichiometry:c52 : 1
stoichiometry:c51 : 1

m979*m5*0.1

nodelay

--

true

0

false

PMID: 18573338, 17457343 CpG-B also induces activation of IRF-5 and production of IkB¦Æ to facilitate the transcriptional regulation of the proinflammatory cytokine genes.

Go back
566.0, 1150.0
19.0, 19.0

p19

p19

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e27 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c53 : 1

m28*m27*0.1

nodelay

--

true

0

false

PMID: 18573338, 17457343 CpG-B also induces activation of IRF-5 and production of IkB¦Æ to facilitate the transcriptional regulation of the proinflammatory cytokine genes.

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1182.0, 646.0
19.0, 19.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e5 MO000016573

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m5*m1572*0.1

nodelay

--

true

0

false

PMID: 18573338, 17572678 Its homodimerized form binds endocytosed CpG DNA through its ectodomain, changes its conformation, and allosterically transmits signaling through the cytoplasmic Toll/IL-1 receptor domain interaction with myeloid differentiation factor 88 (MyD88), TNF receptor-associated factor 6 (TRAF6), and IL-1 receptor-associated kinase 1 (IRAK1) and IRAK4.

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625.0, 621.0
21.0, 21.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000007685 e11

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c56 : 1
stoichiometry:c57 : 1
stoichiometry:c58 : 1

m970*m11*0.1

nodelay

--

true

0

false

PMID: 18573338, 17018642, 17273999 CpG-B induces IRF-1 interaction with MyD88, which crucially licenses IRF-1 transmigration into the nucleus and TLR9-mediated gene-induction programs such as IFN-¦Â, inducible NO synthetase, and IL-12 p35.

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532.0, 1032.0
23.0, 23.0

p21

p21

cso30:i:ME_Translocation

cso30:i:CC_Cytoplasm

--

e29

e30 e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m30*0.1

nodelay

--

true

0

false

PMID: 18573338, 17018642, 17273999 CpG-B induces IRF-1 interaction with MyD88, which crucially licenses IRF-1 transmigration into the nucleus and TLR9-mediated gene-induction programs such as IFN-¦Â, inducible NO synthetase, and IL-12 p35.

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990.0, 1361.5
20.5, 20.5

p22

p22

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c62 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18573338, 17018642, 17273999 CpG-B induces IRF-1 interaction with MyD88, which crucially licenses IRF-1 transmigration into the nucleus and TLR9-mediated gene-induction programs such as IFN-¦Â, inducible NO synthetase, and IL-12 p35.

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902.0, 1178.5
19.5, 19.5

p23

p23

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

G010514

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c64 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18573338, 17018642, 17273999 CpG-B induces IRF-1 interaction with MyD88, which crucially licenses IRF-1 transmigration into the nucleus and TLR9-mediated gene-induction programs such as IFN-¦Â, inducible NO synthetase, and IL-12 p35.

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785.0, 1494.0
21.0, 21.0

p24

p24

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e30

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c66 : 1

m31*0.1

nodelay

--

true

0

false

PMID: 18573338, 17018642, 17273999 CpG-B induces IRF-1 interaction with MyD88, which crucially licenses IRF-1 transmigration into the nucleus and TLR9-mediated gene-induction programs such as IFN-¦Â, inducible NO synthetase, and IL-12 p35.

Go back
933.0, 557.0
21.0, 21.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000042012 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c70 : 1

m19828*m34*0.1

nodelay

--

true

0

false

PMID: 18573338, 17452530, 18305481 Recently, a polytopic membrane protein, UNC93B1, was demonstrated to directly associate with TLR9 and crucially regulate its function by directing subcellular trafficking.

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742.0, 50.0
19.0, 19.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e35 MO000044940

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c72 : 1
stoichiometry:c73 : 1

m36*m22603*0.1

nodelay

--

true

0

false

PMID: 18573338 Recombinant HMGB1 protein directly associates with CpG-A.

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737.0, 180.5
22.5, 22.5

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e36 e37

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m37*m38*0.1

nodelay

--

true

0

false

Go back
1198.0, 1346.0
19.0, 19.0

p28

p28

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17 e38

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c77 : 1

m17*m39*0.1

nodelay

--

true

0

false

PMID: 18573338, 17417641 Coadministration of HMGB1 with CpG-A synergistically activates pDCs to produce IFN-¦Á through the association with cell surface receptor for advanced glycosylation end products (RAGEs).

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261.0, 389.0
22.0, 22.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e39 e40 e41

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1
stoichiometry:c83 : 1

m40*m41*m42*0.1

nodelay

--

true

0

false

PMID: 18573338, 18287072 pDCs express a cell type-specific variant of triggering receptor expressed in myeloid cell (TREM) family members, PDC-TREM, which associates with cell surface semaphorin receptor plexin-A1 and adaptor protein DNAX-activation protein 12 (DAP12)

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1185.0, 725.0
21.0, 21.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e11 MO000039077

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m11*m17258*0.1

nodelay

--

true

0

false

PMID: 18573338, 17572678 Its homodimerized form binds endocytosed CpG DNA through its ectodomain, changes its conformation, and allosterically transmits signaling through the cytoplasmic Toll/IL-1 receptor domain interaction with myeloid differentiation factor 88 (MyD88), TNF receptor-associated factor 6 (TRAF6), and IL-1 receptor-associated kinase 1 (IRAK1) and IRAK4.

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436.0, 1176.0
23.0, 23.0

p30

p30

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e43 e35

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c86 : 1
stoichiometry:c85 : 1

m44*m36*0.1

nodelay

--

true

0

false

PMID: 18573338, 18287072 Cell surface expression of PDC-TREM is upregulated upon CpG-A stimulation, whereas neutralization or knock down of this molecule result in a significant reduction of CpG-A-induced IFN-¦Á production, suggesting that PDC-TREM is engaged in DAP12-mediated positive-feedback signal amplification to trigger robust production of IFN-¦Á.

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1260.0, 1176.0
23.0, 23.0

p31

p31

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17 e42

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c87 : 1
stoichiometry:c90 : 1
stoichiometry:c88 : 1

m17*m43*0.1

nodelay

--

true

0

false

PMID: 18573338, 18287072 Cell surface expression of PDC-TREM is upregulated upon CpG-A stimulation, whereas neutralization or knock down of this molecule result in a significant reduction of CpG-A-induced IFN-¦Á production, suggesting that PDC-TREM is engaged in DAP12-mediated positive-feedback signal amplification to trigger robust production of IFN-¦Á.

Go back
918.0, 178.0
19.0, 19.0

p32

p32

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e10 e45

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c91 : 1
stoichiometry:c93 : 1

m10*m46*0.1

nodelay

--

true

0

false

PMID: 18573338, 17873860 Recently, antimicrobial peptide LL37 (also known as cathelicidin antimicrobial peptide), overexpressed in psoriatic skin, was demonstrated to interact with self-DNA to form aggregated structures, which are also delivered to and retained in the early endosomes to trigger TLR9-mediated innate immune activation.

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1263.0, 459.0
17.0, 17.0

p33

p33

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000022224 e46

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1
stoichiometry:c96 : 1

m119368*m47*0.1

nodelay

--

true

0

false

PMID: 18573338, 17517627 in vitro analysis demonstrated that RIG-I directly binds to 5¡ì-triphosphorylated RNA but not to B-DNA.

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945.0, 413.0
21.0, 21.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000061425 e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c98 : 1
stoichiometry:c99 : 1

m36323*m49*0.1

nodelay

--

true

0

false

PMID: 18573338 ZBP1/DAI physically interacts with B-DNA and downstream signaling molecules TBK1 and IRF-3.

Go back
722.0, 546.5
19.5, 19.5

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000019331 MO000061425

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c102 : 1

m3902*m36323*0.1

nodelay

--

true

0

false

PMID: 18573338 ZBP1/DAI physically interacts with B-DNA and downstream signaling molecules TBK1 and IRF-3.

Go back
754.0, 490.0
19.0, 19.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000061425 MO000007694

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c103 : 1
stoichiometry:c105 : 1
stoichiometry:c104 : 1

m36323*m977*0.1

nodelay

--

true

0

false

PMID: 18573338 ZBP1/DAI physically interacts with B-DNA and downstream signaling molecules TBK1 and IRF-3.

Go back
756.0, 364.0
23.0, 23.0

p37

p37

cso30:i:ME_Oligomerization

cso30:i:CC_Cytoplasm

--

MO000061425 e48

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c108 : 1
stoichiometry:c107 : 1

m36323*m49*0.1

nodelay

--

true

0

false

PMID: 18573338, 18375758 B-DNA induces oligomerization of ZBP1/DAI that has been overexpressed in L929 cells, whereas artificially oligomerized ZBP/DAI alone can activate signaling, suggesting that oligomerization of ZBP/DAI is a crucial step for B-DNA-mediated signaling.

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457.0, 537.0
21.0, 21.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e68 e67

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m69*m68*0.1

nodelay

--

true

0

false

PMID: 18573338, 17964261, 17599095 ASC plays an alternative role in pyroptosome by associating with a noninflammasome protein, pyrin, for caspase-1 activation in a process leading to a distinct form of cell death, pyroptosis.

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450.0, 870.0
19.0, 19.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

MO000016828 e69

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c114 : 1
stoichiometry:c110 : 1

m1765*m70*0.1

nodelay

--

true

0

false

PMID: 18573338, 17964261, 17599095 ASC plays an alternative role in pyroptosome by associating with a noninflammasome protein, pyrin, for caspase-1 activation in a process leading to a distinct form of cell death, pyroptosis.

Go back
1189.0, 769.5
21.5, 21.5

p4

p4

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e12 e13

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m12*m13*0.1

nodelay

--

true

0

false

PMID: 18573338, 17572678 Its homodimerized form binds endocytosed CpG DNA through its ectodomain, changes its conformation, and allosterically transmits signaling through the cytoplasmic Toll/IL-1 receptor domain interaction with myeloid differentiation factor 88 (MyD88), TNF receptor-associated factor 6 (TRAF6), and IL-1 receptor-associated kinase 1 (IRAK1) and IRAK4.

Go back
572.0, 1540.0
23.0, 23.0

p40

p40

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010389 e48

MO000019449

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c120 : 1
stoichiometry:c116 : 1

m93364*m49*0.1

nodelay

--

true

0

false

PMID: 18573338 B-DNA-mediated production of proinflammatory cytokines such as IL-1¦Â, IL-18, and IL-33 whose secretion are regulated by caspase-1.

Go back
477.0, 1372.0
23.0, 23.0

p41

p41

cso30:i:ME_Processing

cso30:i:CC_Cytoplasm

--

MO000019449 e66

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c119 : 1
stoichiometry:c118 : 1

m4012*m67*0.1

nodelay

--

true

0

false

PMID: 18573338 B-DNA-mediated production of proinflammatory cytokines such as IL-1¦Â, IL-18, and IL-33 whose secretion are regulated by caspase-1.

Go back
438.0, 1558.0
19.0, 19.0

p42

p42

cso30:i:ME_Processing

cso30:i:CC_Cytoplasm

--

MO000007330 e66

MO000016625

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c123 : 1
stoichiometry:c125 : 1
stoichiometry:c124 : 1

m841*m67*0.1

nodelay

--

true

0

false

PMID: 18573338 B-DNA-mediated production of proinflammatory cytokines such as IL-1¦Â, IL-18, and IL-33 whose secretion are regulated by caspase-1.

Go back
608.0, 1620.0
15.0, 15.0

p43

p43

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e70 e48

MO000007330

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c131 : 1
stoichiometry:c121 : 1

m71*m49*0.1

nodelay

--

true

0

false

PMID: 18573338 B-DNA-mediated production of proinflammatory cytokines such as IL-1¦Â, IL-18, and IL-33 whose secretion are regulated by caspase-1.

Go back
873.0, 1677.0
21.0, 21.0

p44

p44

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

e71 e48

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c126 : 1
stoichiometry:c132 : 1
stoichiometry:c127 : 1

m72*m49*0.1

nodelay

--

true

0

false

PMID: 18573338 B-DNA-mediated production of proinflammatory cytokines such as IL-1¦Â, IL-18, and IL-33 whose secretion are regulated by caspase-1.

Go back
556.0, 1676.0
23.0, 23.0

p45

p45

cso30:i:ME_Processing

cso30:i:CC_Cytoplasm

--

e72 e66

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c128 : 1
stoichiometry:c130 : 1
stoichiometry:c129 : 1

m73*m67*0.1

nodelay

--

true

0

false

PMID: 18573338 B-DNA-mediated production of proinflammatory cytokines such as IL-1¦Â, IL-18, and IL-33 whose secretion are regulated by caspase-1.

Go back
1130.0, 190.0
19.0, 19.0

p46

p46

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e74 e75

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1
stoichiometry:c135 : 1

m75*m76*0.1

nodelay

--

true

0

false

PMID: 18573338 Human Fc¦ÃRIIa or mouse Fc¦ÃRIII is an essential player for TLR9 sensing of the self-DNA?Ig complex inside the cell.

Go back
1217.0, 186.0
17.0, 17.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e77 e74

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m78*m75*0.1

nodelay

--

true

0

false

PMID: 18573338 Human Fc¦ÃRIIa or mouse Fc¦ÃRIII is an essential player for TLR9 sensing of the self-DNA?Ig complex inside the cell.

Go back
1222.0, 594.0
19.0, 19.0

p48

p48

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e78 MO000042012

e79 e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1
stoichiometry:c142 : 1

m79*m19828*0.1

nodelay

--

true

0

false

PMID: 18573338 Human Fc¦ÃRIIa or mouse Fc¦ÃRIII is an essential player for TLR9 sensing of the self-DNA?Ig complex inside the cell. PMID: 18573338 chromatin?IgG complex is delivered to the TLR9-containing endosomes in a human Fc¦ÃRIIa-dependent manner or mouse Fc¦ÃRIII-dependent manner

Go back
1086.0, 446.0
19.0, 19.0

p49

p49

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000042012 e76

e75 e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c143 : 1
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m19828*m77*0.1

nodelay

--

true

0

false

PMID: 18573338 Human Fc¦ÃRIIa or mouse Fc¦ÃRIII is an essential player for TLR9 sensing of the self-DNA?Ig complex inside the cell. PMID: 18573338 chromatin?IgG complex is delivered to the TLR9-containing endosomes in a human Fc¦ÃRIIa-dependent manner or mouse Fc¦ÃRIII-dependent manner

Go back
1197.0, 825.0
21.0, 21.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000000212

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m14*m183*0.1

nodelay

--

true

0

false

PMID: 18573338, 17572678 Its homodimerized form binds endocytosed CpG DNA through its ectodomain, changes its conformation, and allosterically transmits signaling through the cytoplasmic Toll/IL-1 receptor domain interaction with myeloid differentiation factor 88 (MyD88), TNF receptor-associated factor 6 (TRAF6), and IL-1 receptor-associated kinase 1 (IRAK1) and IRAK4.

Go back
1175.0, 942.5
18.5, 18.5

p6

p6

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007702 e14

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m980*m14*0.1

nodelay

--

true

0

false

PMID: 18573338, 18262306 CpG-A activates kinases, such as IRAK1 and I¦ÊB kinase-¦Á (IKK-¦Á), and an E3 ligase, TRAF6, resulting in phosphorylation and ubiquitination of IRF-7, and robust production of IFN-¦Á.

Go back
1176.0, 1096.0
23.0, 23.0

p7

p7

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000041457 e15

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c21 : 1
stoichiometry:c20 : 1

m19325*m15*0.1

nodelay

--

true

0

false

PMID: 18573338, 18262306 CpG-A activates kinases, such as IRAK1 and I¦ÊB kinase-¦Á (IKK-¦Á), and an E3 ligase, TRAF6, resulting in phosphorylation and ubiquitination of IRF-7, and robust production of IFN-¦Á.

Go back
1186.0, 1262.0
19.0, 19.0

p8

p8

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e17

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c23 : 1
stoichiometry:c22 : 1

m17*0.1

nodelay

--

true

0

false

PMID: 18573338, 18262306 CpG-A activates kinases, such as IRAK1 and I¦ÊB kinase-¦Á (IKK-¦Á), and an E3 ligase, TRAF6, resulting in phosphorylation and ubiquitination of IRF-7, and robust production of IFN-¦Á.

Go back
981.0, 1217.0
21.0, 21.0

p9

p9

cso30:i:ME_GeneExpression

cso30:i:CC_Cytosol

--

e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c24 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 18573338, 18262306 CpG-A activates kinases, such as IRAK1 and I¦ÊB kinase-¦Á (IKK-¦Á), and an E3 ligase, TRAF6, resulting in phosphorylation and ubiquitination of IRF-7, and robust production of IFN-¦Á.

Go back
1089.0, 629.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.0, 770.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 572.6198061951341

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
747.8076214712466, 439.0

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
680.8057300167486, 544.7523067384537

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
779.5204669982018, 435.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
667.0, 500.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 457.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
786.2470588235294, 384.38823529411764

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
698.0, 376.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
786.9822812628529, 366.0

c108

c108

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
467.08910470500905, 827.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1219.0, 780.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
461.0, 889.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
468.0, 494.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
486.0, 548.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
458.9658558131846, 558.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
456.0, 664.0

c114

c114

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
603.0, 1552.0

c115

c115

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
510.89547372126214, 1509.0561610125071

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
488.0, 1402.999446424246

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
318.0, 1384.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
469.0, 951.0

c119

c119

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1166.5857022873224, 788.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.318604848719, 371.0

c120

c120

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
538.0, 1628.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
630.9645579131932, 1610.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
462.98677551382514, 1581.3064601145268

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.8552500606081, 1570.0

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
448.26344846803505, 951.0

c125

c125

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
900.4225966213324, 1580.0

c126

c126

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
716.0, 1688.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
587.0, 1688.0

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
302.0, 1688.0

c129

c129

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1160.0, 820.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 951.0

c130

c130

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
620.0087730719497, 371.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
885.3610406493771, 371.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1137.0, 162.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1077.0, 215.5153660540384

c134

c134

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.6389052329816, 209.0

c135

c135

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1224.0, 210.99730276458956

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1148.0, 154.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1233.0, 203.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1235.5433349445989, 299.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1224.9459451369958, 845.9691115068547

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1089.0, 607.189632179376

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1001.9987691360801, 604.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1225.2035704242278, 326.9974095232381

c142

c142

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1074.0, 472.9185075822004

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1099.189252003367, 293.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1069.7214202482928, 335.81259958840633

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
998.7201327147385, 465.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1149.282931819701, 841.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1202.0, 952.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.1873448469985, 961.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1154.0, 837.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1140.0, 1057.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1128.5172413793102, 642.0

c2

c2

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1199.0, 1108.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1134.0, 894.0

c21

c21

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1205.0, 1276.0

c22

c22

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.0, 1275.8669836198026

c23

c23

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
994.0, 1238.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.3681398969907, 1117.0

c25

c25

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
791.0, 753.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.6800773412384, 862.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
865.9804501005061, 853.5589420303857

c28

c28

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1230.844000632146, 960.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
686.0, 115.0

c3

c3

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.7492919018569, 994.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.0, 922.0

c31

c31

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
840.0, 634.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
921.7138767651443, 677.1204021439734

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
908.0, 682.0

c34

c34

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
869.7611400011626, 1016.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
849.4279577709729, 1034.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.0, 933.0

c37

c37

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.0, 944.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.8776860867976, 1030.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1123.0, 659.9711902327327

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
693.6000288035282, 876.0

c40

c40

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.330647868242, 1238.9652488049373

c41

c41

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
457.2653354651449, 1229.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
602.2400225246611, 816.0

c43

c43

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
601.2332154634527, 706.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.0, 760.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
603.9331863031164, 754.0317727850874

c46

c46

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1269.809384816779, 966.0

c47

c47

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1148.9893198795369, 1037.0

c48

c48

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
658.0, 825.0

c49

c49

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1209.0, 656.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.0, 1082.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.909274117848, 1122.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.2063309876478, 689.0

c52

c52

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
524.0, 1160.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
590.8739573171631, 1173.4310795829326

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
592.2044130909167, 1142.0

c55

c55

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
630.0, 595.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
653.8311626034539, 635.6348982470677

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
646.0, 636.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
561.424262258598, 754.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1151.6274302184634, 665.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 1052.0

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
555.0, 745.6868994967369

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1000.0, 1382.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.0, 1227.0

c63

c63

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
912.0, 1198.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
795.0, 1191.6812243389893

c65

c65

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
806.0, 1506.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
781.0, 1231.0

c67

c67

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
961.2531301420403, 576.375218976989

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
959.2542459584337, 526.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.0, 736.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.3805211953236, 578.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.0, 71.46701094871993

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
769.0, 60.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
760.0, 69.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
765.9867755138251, 143.0

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
714.0, 210.32415563218427

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
751.0, 203.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1217.0, 1328.2829174186304

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1036.0, 1321.0

c78

c78

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
779.0, 306.0

c79

c79

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1213.5894663844042, 722.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.8485922262113, 383.0

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
290.1554175279993, 408.5777087639997

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
291.0, 400.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
280.0, 411.0

c83

c83

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
464.61160157321336, 1204.7017477832248

c84

c84

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
374.749269265942, 407.9648349365894

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
452.6807633697056, 115.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1036.0, 1197.5263248462736

c87

c87

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1274.0, 1199.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1164.6564023547028, 744.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 546.0

c90

c90

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
906.0, 111.0

c91

c91

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 188.0

c92

c92

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 138.30004000806068

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1272.0, 391.0

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1191.0, 470.31519189844283

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1170.5970291928218, 434.5070196336312

c96

c96

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
888.0, 424.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 371.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
922.0570138197744, 434.0

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back