1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18631453.csml convertedTime:2009.07.01.11:20

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title When signaling pathways collide: positive and negative regulation of toll-likereceptor signal transduction.
Authors O'Neill LA.
Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2,Ireland. laoneill@tcd.ie
Abstract Toll-like receptor (TLR) signaling is subjected to crosstalk from other signals,with a resulting positive or negative effect. There is complex crosstalk betweenthe NLR family of immune-regulatory molecules and TLRs, and C-type lectinreceptors such as Dectin-1 synergize with TLR2 via the tyrosine kinase Syk.Bruton's tyrosine kinase plays an important positive role in TLR signaling,whereas the TAM family of receptor tyrosine kinases is inhibitory. The tyrosinephosphatase SHP1 has been shown to positively regulate induction ofinterferon-beta, whereas SHP2 inhibits the kinase TBK1, limiting this response.K63-linked polyubiquination has also been shown to be critical for theinitiation of TLR signaling. Finally, glucocorticoids affect TLR signaling byinducing the phosphatase MKP1 and inhibiting TBK1 activation. These recentfindings emphasize the importance of considering TLR signaling in the context ofother signaling pathways, as is likely to occur in vivo during infection andinflammation.
PMID 18631453
Model Abstract

Entity

G010228:IFN-beta G010389:IL-1beta G010539:SOCS1 G011345:IL10 G011404:MKP-1 G011948:SOCS3 MO000000011:ERK MO000000022:p38 MO000000030:PI3K MO000000048:AKT MO000000058:NF-kappaB MO000000085:Src MO000000102:PLCgamma {activated} MO000000144:Lyn MO000000212:TRAF6 MO000000213:IRAK-1 MO000000220:IkappaB-alpha{p} MO000000233:IkappaB-alpha MO000000331:PIP2 MO000001935:Btk MO000006538:Hck MO000007694:IRF-3 MO000008272:ROS MO000008301:Syk MO000013119:STAT1 MO000016566:IRAK-2 MO000016573:MyD88 MO000016574:TAK1 MO000016588:TAB1 MO000016591:A20 MO000016597:IL-1beta MO000016599:IKK-gamma MO000016632:p50:RelA-p65 MO000016645:PKCepsilon MO000016658:IFN Type I MO000016660:IFNbeta MO000016661:IKK-alpha:IKK-beta:IKK-gamma MO000016828:Caspase-1{activated} MO000016882:LPS MO000016884:SHP-1 MO000016886:SHP-2 MO000016963:TRAF3 MO000016966:MKK3 MO000017004:SOCS-1 MO000017247:IL-10 MO000017793:Lp MO000017818:JNK3 MO000019005:MKK6 MO000019331:TBK1 MO000019387:cytokines MO000019394:TLR4 MO000019395:TLRs MO000019398:TLR3 MO000019449:proIL-1beta MO000019479:protein remnants MO000019656:Dectin-1 MO000020434:Nod1 MO000020461:Nod2 MO000021432:NADPH oxidase MO000021702:Gas6 MO000021732:glucocorticoids MO000022125:TAB2 MO000022136:Ubc13 MO000022139:Uev1 MO000022224:dsRNA MO000033294:p50:RelA-p65{pS} MO000033499:p85:p110 MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041419:Pellino1 MO000041433:Pellino2 MO000041456:IRF-3{p} MO000042012:TLR9: TLR9 MO000063086:P2X7 MO000064988:PANX1 MO000068831:MAL MO000074564:GRIP1 MO000116924:Nalp3 e1: e10: e100:TRAF6 {activated} e101:ligand: TAM: IFNAR1 e102:Src {activated} e103:Hck{activated} e104:Lyn {activated} e105:CpG motif: TLR9: TLR9: Btk e106:LPS: TLR4: Btk e107:LPS: TLR4: MAL{pY86, pT106}: MyD88: SOCS1 e108:LPS: TLR4: MAL{pY86, pT106}: MyD88 e109:LPS: TLR4: MyD88: SOCS1 e11:TLR ligand: TLR: TLR: MyD88 e110:ligand: TRME-1: DAP12 e111:ligand: TRME-1: DAP12{pY} e112:ligand: TRME-1: DAP12{pY}: p85:p110 e113:ligand: TRME-1: DAP12{pY}: PLCgamma e114:cytokine e115:antibody e116:antibody: TLR4 e117:CD32A e118:antibody: TLR4: CD32A e119:PI3K {activated} e12:LPS: TLR4 e120:AKT {activated} e121:PLCgamma e122:TAM e123:Gas6: TAM e124:Axl: IFNAR1 e125:Gas6: TAM: Axl:IFNAR1 e126:STAT1 {activated} e127:TLR ligand: TLR: TLR: MyD88: IRAK-1{p}: SHP-1: IRAK-2: IRAK-4 e128:TLR ligand: TLR: TLR: MyD88: IRAK-4 e129:type I interferon e13:LPS: TLR4: MAL e130:Rig-1 e131:IL-1: IL-1R e132:IL-1: IL-1R: MyD88 e133:dsRNA: TLR3: IRAK-2 e134:TLR ligand: TLR: TLR: MyD88: IRAK-1{activated}: IRAK-4 e135:IRAK-1{p}: IRAK-2: IRAK-4: Pellino1: Pellino2 e136:TRAF6{ub} e137:IRAK-1{p}: IRAK-2: IRAK-4: Pellino1: Pellino2 e138:IRAK-1{p}{ub}: IRAK-2: IRAK-4: Pellino1: Pellino2 e139:IRAK-1{p}{ub}: IRAK-2: IRAK-4: Pellino1: Pellino2: IKK-gamma e14:TLR1: TLR2 e140:IRAK-2: IRAK-4 e141:IRAK-1{p}{ub}: IRAK-2: IRAK-4: TRFA6 e142:TRIM20 e143:glucocorticoid receptor e144:GRIP1: glucocorticoid receptor e145:IRF-3{p}: GRIP1 e146:TAB1{ub} e147:TAB2{ub} e15:TLR6: TLR2 e16:Lp: TLR1: TLR2 e17:Lp: TLR6: TLR2 e18:Lp: TLR6: TLR2: MAL e19:dsRNA: TLR3 e2: e20:CpG motif e21: e22: e23: e24:CpG motif: TLR9: TLR9 e25:iE-DAP e26:MDP e27:iE-DAP: Nod1 e28:MDP: Nod2 e29:uric acid crystals e3: e30:MDP: Nalp3 e31:uric acid crystals: Nalp3 e32:IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2: MKK3 e33:asbestos e34:asbestos: Nalp3 e35:ssRNA e36:RIG-1 e37:sRNA: RIG-1 e38:beta-glucan e39:beta-glucan: Dectin-1 e4: e40:TLR ligand: TLR: TLR e41:TLR ligand: TLR: TLR: MyD88: IRAK-1: IRAK-4: IRAK-2 e42:TLR ligand: TLR: TLR: MyD88: IRAK-1{activated}: IRAK-4 e43:TLR ligand: TLR: TLR: MyD88: IRAK-1: IRAK-4: IRAK-2{activated} e44:IRAK-1{p}: IRAK-2: IRAK-4: TRFA6 e45:IRAK-1{p}: IRAK-2: IRAK-4 e46:IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1 e47:IRAK-1{p}: IRAK-2: IRAK-4: TRFA6: Ubc13: Uev1 e48:IRAK-1{p}: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1: TAB1: TAB2 e49:IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2 e5:TLR ligand e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TLR ligand: TLR e60: e61: e62: e63:IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2: IKK-alpha:IKK-beta:IKK-gamma e64:IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2: MKK6 e65:NF-kappaB {activated} e66:p38 {p} e67:ERK {activated} e68:LPS: TLR4: MAL: MyD88 e69:Lp: TLR6: TLR2: MAL: MyD88 e7: e70:LPS: TLR4: TRAM e71:LPS: TLR4: TRAM: TRIF e72:dsRNA: TLR3: TRIF e73:LPS: TLR4 e74:LPS: TLR4: TRAM: TRIF: TRAF{activated}: TBK1 e75:dsRNA: TLR3: TRIF: TBK1 e76:LPS: TLR4: TRAM: TRIF: TRAF3 e77:LPS: TLR4: TRAM: TRIF: TRAF3{activated} e78:LPS: TLR4: TRAM: TRIF: TRAF{activated}: TBK1{activated} e79:dsRNA: TLR3: TRIF: TBK1{activated} e8: e80:MAL{membrane} e81:TRAm{myristoylated} e82:MAL{myristoylated} e83:TRAM{membrane} e84:TRAM{pS16} e85:SARM e86:JNK3: SARM e87:TcpC e88:TcpC: MyD88 e89:ATP e9: e90:ATP: Nalp3 e91:silica e92:silica: Nalp3 e93:Nalp3{activated} e94:potassium{extracellular} e95:potassium e96:R837 e97:Caspase-1 e98:R837: TLR7 e99:R837: TLR7: MyD88

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p130 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
710.0, 1750.0
28.0, 28.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p110

p109

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
717.0, 1467.0
26.0, 26.0

IL-1beta

--

G010389

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p63

p52

true true true true

csml-variable:Double

m93364

10

false

infinite

0

unit false false false
TRANSFACG010389

--

Go back
750.0, 1688.0
32.0, 32.0

SOCS1

--

G010539

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p70 p99

--

true true true true

csml-variable:Double

m93501

10

false

infinite

0

unit false false false
TRANSFACG010539

--

Go back
841.0, 1653.0
29.5, 29.5

IL10

--

G011345

cso30:c:mRNA

cso30:i:CC_CellComponent

--

--

p79 p80

true true true true

csml-variable:Double

m94230

10

false

infinite

0

unit false false false
TRANSFACG011345

--

Go back
633.0, 1521.0
30.0, 30.0

MKP-1

--

G011404

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p124

p125

true true true true

csml-variable:Double

m94283

10

false

infinite

0

unit false false false
TRANSFACG011404

--

Go back
803.0, 1669.0
30.0, 30.0

SOCS3

--

G011948

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p100

--

true true true true

csml-variable:Double

m94757

10

false

infinite

0

unit false false false
TRANSFACG011948

--

Go back
599.0, 802.0
32.0, 32.0

ERK

--

MO000000011

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33

true true true true

csml-variable:Double

m70

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
574.0, 669.0
25.0, 25.0

p38

--

MO000000022

cso30:c:Protein

cso30:i:CC_CellComponent

--

p125

p120 p81

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
1051.0, 907.0
30.0, 30.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p91

true true true true

csml-variable:Double

m125

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
924.0, 924.0
28.0, 28.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p92

true true true true

csml-variable:Double

m127

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
788.0, 1008.0
32.0, 32.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p31 p62 p65

true true true true

csml-variable:Double

m5

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
1217.0, 956.0
26.0, 26.0

Src

--

MO000000085

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p71

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000085

--

Go back
483.0, 870.0
30.0, 30.0

PLCgamma {activated}

--

MO000000102

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p87 p93 p94 p95

true true true true

csml-variable:Double

m119

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
1221.0, 1099.0
25.0, 25.0

Lyn

--

MO000000144

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m128

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
1010.0, 594.0
28.0, 28.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22 p64 p116

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
1044.0, 477.0
30.0, 30.0

IRAK-1

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
746.0, 949.0
34.0, 34.0

IkappaB-alpha{p}

--

MO000000220

cso30:c:Protein

cso30:i:CC_CellComponent

--

p28

p31

true true true true

csml-variable:Double

m190

10

false

infinite

0

unit false false false
TRANSPATHMO000000220

--

Go back
743.0, 906.0
32.0, 32.0

IkappaB-alpha

--

MO000000233

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p28

true true true true

csml-variable:Double

m199

10

false

infinite

0

unit false false false
InterProIPR002110
TRANSPATHMO000000233

--

Go back
1207.0, 403.0
26.0, 26.0

PIP2

--

MO000000331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p94

p48

true true true true

csml-variable:Double

m290229

10

false

infinite

0

unit false false false
TRANSPATHMO000000331

--

Go back
1229.0, 1547.0
28.0, 28.0

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p74 p75 p82 p81

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
1216.0, 1027.0
28.0, 28.0

Hck

--

MO000006538

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p72

true true true true

csml-variable:Double

m751

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000006538

--

Go back
836.0, 1344.0
32.0, 32.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p107 p108

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
476.0, 1572.0
32.0, 32.0

ROS

--

MO000008272

cso30:c:Protein

cso30:i:CC_CellComponent

--

p59 p69

p57

true true true true

csml-variable:Double

m1063

10

false

infinite

0

unit false false false
TRANSPATHMO000008272

--

Go back
437.0, 737.0
30.0, 30.0

Syk

--

MO000008301

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p85

true true true true

csml-variable:Double

m1066

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008301

--

Go back
1031.0, 1810.0
30.0, 30.0

STAT1

--

MO000013119

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p98

true true true true

csml-variable:Double

m1357

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1044.0, 517.0
30.0, 30.0

IRAK-2

--

MO000016566

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p113

true true true true

csml-variable:Double

m1569

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016566

--

Go back
864.0, 412.0
32.0, 32.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2 p34 p35 p51 p61 p112

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1065.0, 681.0
38.0, 38.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1078.0, 738.0
28.0, 28.0

TAB1

--

MO000016588

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p129

true true true true

csml-variable:Double

m1583

10

false

infinite

0

unit false false false
InterProIPR001932
TRANSPATHMO000016588

--

Go back
1034.0, 638.0
27.0, 27.0

A20

--

MO000016591

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p116

true true true true

csml-variable:Double

m1585

10

false

infinite

0

unit false false false
InterProIPR002653
TRANSPATHMO000016591

--

Go back
534.0, 1277.0
32.0, 32.0

IL-1beta

--

MO000016597

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

--

true true true true

csml-variable:Double

m1591

10

false

infinite

0

unit false false false
TRANSPATHMO000016597

--

Go back
506.0, 638.0
28.0, 28.0

IKK-gamma

--

MO000016599

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p119

true true true true

csml-variable:Double

m1593

10

false

infinite

0

unit false false false
InterProIPR007087
TRANSPATHMO000016599

--

Go back
1041.0, 1620.0
35.0, 35.0

p50:RelA-p65

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p76 p77

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
843.0, 1107.0
29.0, 29.0

PKCepsilon

--

MO000016645

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m1629

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016645

--

Go back
594.0, 1842.0
28.0, 28.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p105 p106

--

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
742.0, 1838.0
28.0, 28.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p109

--

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
970.0, 857.0
34.0, 34.0

IKK-alpha:IKK-beta:IKK-gamma

--

MO000016661

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27

true true true true

csml-variable:Double

m1637

10

false

infinite

0

unit false false false
TRANSPATHMO000016661

--

Go back
536.0, 1325.0
34.0, 34.0

Caspase-1{activated}

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58 p60 p66 p67 p68

p53

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
1388.0, 362.0
28.0, 28.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p58

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false
TRANSPATHMO000016882

--

Go back
1141.0, 365.0
30.0, 30.0

SHP-1

--

MO000016884

cso30:c:Protein

cso30:i:CC_CellComponent

--

p102

p101 p106

true true true true

csml-variable:Double

m1805

10

false

infinite

0

unit false false false
InterProIPR000242
TRANSPATHMO000016884

--

Go back
881.0, 1453.0
30.0, 30.0

SHP-2

--

MO000016886

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p41 p110 p111

true true true true

csml-variable:Double

m1807

10

false

infinite

0

unit false false false
InterProIPR000242
TRANSPATHMO000016886

--

Go back
908.0, 1187.0
30.0, 30.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p42

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
741.0, 664.0
28.0, 28.0

MKK3

--

MO000016966

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p29

true true true true

csml-variable:Double

m1875

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016966

--

Go back
1238.0, 674.0
27.0, 27.0

SOCS-1

--

MO000017004

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p83

true true true true

csml-variable:Double

m1906

10

false

infinite

0

unit false false false
InterProIPR001496
TRANSPATHMO000017004

--

Go back
978.0, 1734.0
30.0, 30.0

IL-10

--

MO000017247

cso30:c:Protein

cso30:i:CC_CellComponent

--

p79 p80

--

true true true true

csml-variable:Double

m2103

10

false

infinite

0

unit false false false
InterProIPR000098
TRANSPATHMO000017247

--

Go back
176.0, 332.0
30.0, 30.0

Lp

--

MO000017793

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p6

true true true true

csml-variable:Double

m2549

10

false

infinite

0

unit false false false
TRANSPATHMO000017793

--

Go back
423.0, 991.0
30.0, 30.0

JNK3

--

MO000017818

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p50

true true true true

csml-variable:Double

m2570

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000017818

--

Go back
740.0, 863.0
30.0, 30.0

MKK6

--

MO000019005

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p30

true true true true

csml-variable:Double

m3613

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019005

--

Go back
905.0, 1285.0
30.0, 30.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p43 p44

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
480.0, 1744.0
32.0, 32.0

cytokines

--

MO000019387

cso30:c:Protein

cso30:i:CC_CellComponent

--

p88

--

true true true true

csml-variable:Double

m3957

10

false

infinite

0

unit false false false
TRANSPATHMO000019387

--

Go back
1302.0, 373.0
30.0, 30.0

TLR4

--

MO000019394

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p89

true true true true

csml-variable:Double

m3961

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019394

--

Go back
555.0, 339.0
25.0, 25.0

TLRs

--

MO000019395

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3962

10

false

infinite

0

unit false false false
TRANSPATHMO000019395

--

Go back
1206.0, 1382.0
20.5, 20.5

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
672.0, 1279.0
28.0, 28.0

proIL-1beta

--

MO000019449

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p53

true true true true

csml-variable:Double

m4012

10

false

infinite

0

unit false false false
InterProIPR003297
TRANSPATHMO000019449

--

Go back
1228.0, 839.0
30.0, 30.0

protein remnants

--

MO000019479

cso30:c:Protein

cso30:i:CC_CellComponent

--

p84 p102 p32 p122 p123

--

true true true true

csml-variable:Double

m360980

10

false

infinite

0

unit false false false
TRANSPATHMO000019479

--

Go back
349.0, 1910.0
28.0, 28.0

Dectin-1

--

MO000019656

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16

true true true true

csml-variable:Double

m4193

10

false

infinite

0

unit false false false
TRANSPATHMO000019656

--

Go back
285.0, 1002.0
28.0, 28.0

Nod1

--

MO000020434

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p10

true true true true

csml-variable:Double

m4923

10

false

infinite

0

unit false false false
InterProIPR007091
TRANSPATHMO000020434

--

Go back
281.0, 1040.0
28.5, 28.5

Nod2

--

MO000020461

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p11

true true true true

csml-variable:Double

m4947

10

false

infinite

0

unit false false false
TRANSPATHMO000020461

--

Go back
491.0, 1390.0
32.0, 32.0

NADPH oxidase

--

MO000021432

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59 p69

true true true true

csml-variable:Double

m5783

10

false

infinite

0

unit false false false
TRANSPATHMO000021432

--

Go back
1092.0, 1987.0
28.0, 28.0

Gas6

--

MO000021702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p96

true true true true

csml-variable:Double

m6039

10

false

infinite

0

unit false false false
InterProIPR006209
TRANSPATHMO000021702

--

Go back
579.0, 1439.0
26.0, 26.0

glucocorticoids

--

MO000021732

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p124

true true true true

csml-variable:Double

m6069

10

false

infinite

0

unit false false false
TRANSPATHMO000021732

--

Go back
1079.0, 779.0
26.0, 26.0

TAB2

--

MO000022125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p130

true true true true

csml-variable:Double

m6433

10

false

infinite

0

unit false false false
TRANSPATHMO000022125

--

Go back
817.0, 608.0
28.0, 28.0

Ubc13

--

MO000022136

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m6443

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022136

--

Go back
816.0, 659.0
30.0, 30.0

Uev1

--

MO000022139

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p24

true true true true

csml-variable:Double

m6446

10

false

infinite

0

unit false false false
InterProIPR000608
TRANSPATHMO000022139

--

Go back
1396.0, 1316.0
32.0, 32.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1041.0, 1663.0
32.0, 32.0

p50:RelA-p65{pS}

--

MO000033294

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76 p77

--

true true true true

csml-variable:Double

m11984

10

false

infinite

0

unit false false false
TRANSPATHMO000033294

--

Go back
446.0, 810.0
32.0, 32.0

p85:p110

--

MO000033499

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p86

true true true true

csml-variable:Double

m12175

10

false

infinite

0

unit false false false
TRANSPATHMO000033499

--

Go back
1041.0, 558.0
28.0, 28.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
914.0, 1242.0
28.0, 28.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p38

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
828.0, 1267.0
30.0, 30.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
631.0, 503.0
28.0, 28.0

Pellino1

--

MO000041419

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p117

true true true true

csml-variable:Double

m19287

10

false

infinite

0

unit false false false
TRANSPATHMO000041419

--

Go back
575.0, 507.0
27.0, 27.0

Pellino2

--

MO000041433

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p117

true true true true

csml-variable:Double

m19301

10

false

infinite

0

unit false false false
TRANSPATHMO000041433

--

Go back
836.0, 1384.0
32.0, 32.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p107 p108

p110 p111 p127

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
1143.0, 1491.0
26.0, 26.0

TLR9: TLR9

--

MO000042012

cso30:c:Complex

cso30:i:CC_CellComponent

--

--

p9

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
356.0, 1528.0
32.0, 32.0

P2X7

--

MO000063086

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p57

true true true true

csml-variable:Double

m37969

10

false

infinite

0

unit false false false
TRANSPATHMO000063086

--

Go back
362.0, 1586.0
28.0, 28.0

PANX1

--

MO000064988

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p57

true true true true

csml-variable:Double

m39857

10

false

infinite

0

unit false false false
TRANSPATHMO000064988

--

Go back
1090.0, 399.0
30.0, 30.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p48

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
964.0, 1580.0
32.0, 32.0

GRIP1

--

MO000074564

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p126 p127

true true true true

csml-variable:Double

m49366

10

false

infinite

0

unit false false false
TRANSPATHMO000074564

--

Go back
362.0, 1209.0
26.0, 26.0

Nalp3

--

MO000116924

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p12 p13 p14 p54 p55 p57

true true true true

csml-variable:Double

m86033

10

false

infinite

0

unit false false false
TRANSPATHMO000116924

--

Go back
266.86137150018993, 272.74368282393885
1098.8045215235088, 1679.7532435648984

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
344.43255954337764, 485.5565103316213
937.2268336646739, 1388.0670494687763

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1182.0, 682.0
28.0, 28.0

TRAF6 {activated}

--

e100

cso30:c:Protein

cso30:i:CC_CellComponent

--

p64

p65

true true true true

csml-variable:Double

m104

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
763.875, 1881.5
32.25, 45.0

ligand: TAM: IFNAR1

--

e101

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p70

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
1217.0, 992.0
26.0, 26.0

Src {activated}

--

e102

cso30:c:Protein

cso30:i:CC_CellComponent

--

p71

--

true true true true

csml-variable:Double

m107

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000085

--

Go back
1216.0, 1062.0
28.0, 28.0

Hck{activated}

--

e103

cso30:c:Protein

cso30:i:CC_CellComponent

--

p72

--

true true true true

csml-variable:Double

m108

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000006538

--

Go back
1219.0, 1133.0
27.0, 27.0

Lyn {activated}

--

e104

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m109

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000000144

--

Go back
1071.875, 1517.5
32.25, 45.0

CpG motif: TLR9: TLR9: Btk

--

e105

cso30:c:Complex

cso30:i:CC_Cytosol

--

p74

p76 p78 p79

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1302.875, 1586.5
32.25, 45.0

LPS: TLR4: Btk

--

e106

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p75

p77 p80

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
1302.875, 731.5
32.25, 45.0

LPS: TLR4: MAL{pY86, pT106}: MyD88: SOCS1

--

e107

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p83

p84

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
1303.875, 665.5
32.25, 45.0

LPS: TLR4: MAL{pY86, pT106}: MyD88

--

e108

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p82

p31 p83

true true true true

csml-variable:Double

m113

0

false

infinite

0

unit false false false

--

Go back
1303.875, 781.5
32.25, 45.0

LPS: TLR4: MyD88: SOCS1

--

e109

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p84

--

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
755.875, 305.5
32.25, 45.0

TLR ligand: TLR: TLR: MyD88

--

e11

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2 p20

p18

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
272.375, 653.5
23.25, 45.0

ligand: TRME-1: DAP12

--

e110

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p85 p88

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
275.875, 733.5
32.25, 45.0

ligand: TRME-1: DAP12{pY}

--

e111

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p85

p86 p87

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
282.875, 803.5
32.25, 45.0

ligand: TRME-1: DAP12{pY}: p85:p110

--

e112

cso30:c:Complex

cso30:i:CC_Cytosol

--

p86

--

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
285.875, 878.5
32.25, 45.0

ligand: TRME-1: DAP12{pY}: PLCgamma

--

e113

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p87

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
578.5, 1667.0
38.56401384083045, 20.567474048442907

cytokine

--

e114

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p103 p111

p88

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
1433.0, 298.5
25.846153846153847, 38.76923076923077

antibody

--

e115

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p89

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
1310.625, 302.5
30.96079820029995, 37.91118146975504

antibody: TLR4

--

e116

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p89

p90

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
1274.375, 290.5
23.99516695957821, 36.91564147627417

CD32A

--

e117

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p90

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
1234.875, 300.5
29.882593136355293, 41.69664158561204

antibody: TLR4: CD32A

--

e118

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p90

p91 p93

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
1051.0, 959.0
30.0, 30.0

PI3K {activated}

--

e119

cso30:c:Protein

cso30:i:CC_CellComponent

--

p91

p92

true true true true

csml-variable:Double

m126

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1307.625, 420.5
28.029453424429267, 34.321779703382774

LPS: TLR4

--

e12

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p4 p75

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
902.0, 966.0
28.0, 28.0

AKT {activated}

--

e120

cso30:c:Protein

cso30:i:CC_CellComponent

--

p92

p31 p65

true true true true

csml-variable:Double

m129

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
479.0, 914.0
30.0, 30.0

PLCgamma

--

e121

cso30:c:Protein

cso30:i:CC_CellComponent

--

p93

--

true true true true

csml-variable:Double

m130

10

false

infinite

0

unit false false false
TRANSPATHMO000000102

--

Go back
1053.5, 1917.0
25.657293497363796, 39.472759226713535

TAM

--

e122

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p96

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
1009.5, 1908.0
25.43345757509318, 49.22604691953519

Gas6: TAM

--

e123

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p96

p97

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
962.5, 1918.0
30.340949033391915, 46.67838312829525

Axl: IFNAR1

--

e124

cso30:c:Complex

cso30:i:CC_Extracellular

--

--

p97

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
888.5, 1900.0
41.57166452560102, 58.006973756652606

Gas6: TAM: Axl:IFNAR1

--

e125

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p97

p98

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
879.0, 1810.0
30.0, 30.0

STAT1 {activated}

--

e126

cso30:c:Protein

cso30:i:CC_CellComponent

--

p98

p99 p100

true true true true

csml-variable:Double

m135

10

false

infinite

0

unit false false false
InterProIPR008967
TRANSPATHMO000013119

--

Go back
1080.5, 249.0
44.39677004955036, 61.94898146448889

TLR ligand: TLR: TLR: MyD88: IRAK-1{p}: SHP-1: IRAK-2: IRAK-4

--

e127

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p101

p31 p33 p62 p102 p105 p109 p120

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
1180.5, 240.0
39.804000734079644, 55.54046614057625

TLR ligand: TLR: TLR: MyD88: IRAK-4

--

e128

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p102

--

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
639.5, 1705.0
40.22491349480969, 21.453287197231834

type I interferon

--

e129

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p104

p105 p106

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
1307.875, 544.5
30.829555881813178, 43.017984951367225

LPS: TLR4: MAL

--

e13

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

p34

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
494.5, 1841.125
34.7967397866774, 21.45798953511773

Rig-1

--

e130

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p106

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
349.875, 288.5
29.472242613323544, 41.12405946045146

IL-1: IL-1R

--

e131

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p112

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
392.875, 278.5
32.25, 45.0

IL-1: IL-1R: MyD88

--

e132

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p112

--

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
1172.875, 1442.5
30.829555881813178, 43.017984951367225

dsRNA: TLR3: IRAK-2

--

e133

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

p113

--

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
870.5, 280.0
34.26426867315104, 47.81060745090842

TLR ligand: TLR: TLR: MyD88: IRAK-1{activated}: IRAK-4

--

e134

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p115

p19

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
621.875, 556.5
29.472242613323544, 41.12405946045146

IRAK-1{p}: IRAK-2: IRAK-4: Pellino1: Pellino2

--

e135

cso30:c:Complex

cso30:i:CC_Cytosol

--

p117

p114

true true true true

csml-variable:Double

m69

0

false

infinite

0

unit false false false

--

Go back
1091.5, 844.125
32.36, 24.269999999999996

TRAF6{ub}

--

e136

cso30:c:Protein

cso30:i:CC_Cytosol

--

p116

--

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
498.875, 568.5
32.25, 45.0

IRAK-1{p}: IRAK-2: IRAK-4: Pellino1: Pellino2

--

e137

cso30:c:Complex

cso30:i:CC_Cytosol

--

p114

p118

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
378.875, 580.5
32.25, 45.0

IRAK-1{p}{ub}: IRAK-2: IRAK-4: Pellino1: Pellino2

--

e138

cso30:c:Complex

cso30:i:CC_Cytosol

--

p118

p119 p32

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
375.875, 633.5
32.25, 45.0

IRAK-1{p}{ub}: IRAK-2: IRAK-4: Pellino1: Pellino2: IKK-gamma

--

e139

cso30:c:Complex

cso30:i:CC_Cytosol

--

p119

--

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
275.5, 329.125
45.0, 27.75

TLR1: TLR2

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p6

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
620.875, 655.5
29.472242613323544, 41.12405946045146

IRAK-2: IRAK-4

--

e140

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

--

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
711.875, 497.5
32.25, 45.0

IRAK-1{p}{ub}: IRAK-2: IRAK-4: TRFA6

--

e141

cso30:c:Complex

cso30:i:CC_Cytosol

--

p121

--

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
1102.5, 889.125
35.19521030388408, 21.703713020728518

TRIM20

--

e142

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p129 p130

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
888.375, 1642.5
23.058435852372583, 35.47451669595782

glucocorticoid receptor

--

e143

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p126

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false false false

--

Go back
888.375, 1589.5
23.25, 45.0

GRIP1: glucocorticoid receptor

--

e144

cso30:c:Complex

cso30:i:CC_Nucleoplasm

--

p126

p127 p128

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false false false

--

Go back
769.625, 1333.5
31.099608398600232, 38.08115314114314

IRF-3{p}: GRIP1

--

e145

cso30:c:Complex

cso30:i:CC_Cytosol

--

p127

p128

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false false false

--

Go back
1179.0, 739.5
34.24, 25.679999999999996

TAB1{ub}

--

e146

cso30:c:Protein

cso30:i:CC_Cytosol

--

p129

p123

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false false false

--

Go back
1209.0, 784.5
30.08, 22.56

TAB2{ub}

--

e147

cso30:c:Protein

cso30:i:CC_Cytosol

--

p130

p122

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false false false

--

Go back
275.5, 365.125
45.0, 27.75

TLR6: TLR2

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p5

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
287.875, 278.5
29.472242613323544, 41.12405946045146

Lp: TLR1: TLR2

--

e16

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p6

--

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
274.875, 396.5
32.25, 45.0

Lp: TLR6: TLR2

--

e17

cso30:c:Complex

cso30:i:CC_Cytosol

--

p5

p7

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
274.875, 448.5
32.25, 45.0

Lp: TLR6: TLR2: MAL

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p7

p35

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
1196.625, 1409.5
30.9199716713881, 37.861189801699716

dsRNA: TLR3

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p8

p37 p113

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
266.86137150018993, 272.74368282393885
1098.8045215235088, 1679.7532435648984

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
1393.5, 1540.125
45.0, 15.75

CpG motif

--

e20

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p9

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
952.6070961257652, 1100.3989342536931
277.0033944588778, 462.4548195627035

--

e21

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false true false

--

Go back
952.6070961257652, 1100.3989342536931
277.0033944588778, 462.4548195627035

--

e22

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false true false

--

Go back
952.6070961257652, 1100.3989342536931
277.0033944588778, 462.4548195627035

--

e23

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false true false

--

Go back
1113.625, 1506.5
29.27874520913181, 35.85152474587569

CpG motif: TLR9: TLR9

--

e24

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p9

p74

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
180.5, 1003.25
45.0, 25.5

iE-DAP

--

e25

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
179.5, 1103.25
45.0, 25.5

MDP

--

e26

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p11 p12

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
280.625, 942.5
29.27874520913181, 35.851524745875686

iE-DAP: Nod1

--

e27

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p10

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
283.625, 1094.5
30.65051658056991, 37.53124479253458

MDP: Nod2

--

e28

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p11

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
122.5, 1278.25
41.54331370899916, 23.541211101766187

uric acid crystals

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p13

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
288.83746193065997, 295.8807798427392
1054.8523406625684, 1633.479049527298

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
359.625, 1150.5
31.679345109148482, 38.79103482752875

MDP: Nalp3

--

e30

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p12

p66

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
356.625, 1270.5
33.36956340609898, 40.860689885019156

uric acid crystals: Nalp3

--

e31

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p13

p59 p67

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
739.875, 717.5
32.25, 45.0

IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2: MKK3

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p29

p120

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
130.5, 1332.25
41.54331370899916, 23.541211101766187

asbestos

--

e33

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
357.625, 1323.5
31.099608398600232, 38.08115314114314

asbestos: Nalp3

--

e34

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p14

p68 p69

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
141.5, 1712.625
35.36468330134357, 19.450575815738965

ssRNA

--

e35

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p15

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
303.375, 1651.5
24.26933216168717, 37.33743409490334

RIG-1

--

e36

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p15

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
304.375, 1699.5
23.25, 45.0

sRNA: RIG-1

--

e37

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
343.5, 1969.25
38.313708999158955, 21.711101766190076

beta-glucan

--

e38

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p16

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
416.625, 1898.5
28.870479920013334, 35.351608065322445

beta-glucan: Dectin-1

--

e39

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p16

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
329.49322922703027, 336.3706996256395
973.5408060698288, 1552.499209961497

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
644.5, 315.0
30.00293631859057, 41.8645623050101

TLR ligand: TLR: TLR

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p17

p2

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
802.5, 292.0
34.26426867315104, 47.81060745090842

TLR ligand: TLR: TLR: MyD88: IRAK-1: IRAK-4: IRAK-2

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

p115

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
938.5, 272.0
34.26426867315104, 47.81060745090842

TLR ligand: TLR: TLR: MyD88: IRAK-1{activated}: IRAK-4

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p21

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
1003.875, 264.5
39.360111947146265, 54.92108643787851

TLR ligand: TLR: TLR: MyD88: IRAK-1: IRAK-4: IRAK-2{activated}

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p21

p20 p101 p103 p104

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
875.875, 586.5
30.829555881813178, 43.017984951367225

IRAK-1{p}: IRAK-2: IRAK-4: TRFA6

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

p24 p121

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
931.5, 531.125
45.0, 27.75

IRAK-1{p}: IRAK-2: IRAK-4

--

e45

cso30:c:Protein

cso30:i:CC_Cytosol

--

p20

p22 p117

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
943.875, 705.5
32.25, 45.0

IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1

--

e46

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p25

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
942.875, 651.5
32.25, 45.0

IRAK-1{p}: IRAK-2: IRAK-4: TRFA6: Ubc13: Uev1

--

e47

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

p23

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
996.875, 769.5
37.4661864562305, 52.27839970636814

IRAK-1{p}: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1: TAB1: TAB2

--

e48

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p26

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
895.875, 783.5
37.4661864562305, 52.27839970636814

IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2

--

e49

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p27 p29 p30

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
523.0, 232.5
33.884007029876976, 22.02460456942004

TLR ligand

--

e5

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p1

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false false false

--

Go back
510.7987772764675, 1431.5814531443339
394.74486561731914, 376.9030046141035

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
553.4341631345764, 1440.513506422905
230.8191579214865, 365.29408250073277

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
515.9444272938254, 1436.6119860601277
384.4535655826033, 366.8419387825155

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
516.6795201534482, 1437.3859142010194
382.9833798633578, 365.29408250073277

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
510.7987772764675, 1431.5814531443339
394.74486561731914, 376.9030046141035

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
510.7987772764675, 1431.5814531443339
394.74486561731914, 376.9030046141035

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
516.6795201534482, 1437.3859142010194
382.9833798633578, 365.29408250073277

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
798.9551782485139, 1586.3670813226106
24.66149027649781, 23.50458552198437

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
734.2670066017279, 1694.7170210474044
69.8338216641439, 66.55782011665899

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
510.7987772764675, 1431.5814531443339
394.74486561731914, 376.9030046141035

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
591.625, 324.5
32.29990834860857, 39.550908181969675

TLR ligand: TLR

--

e6

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p17

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false false false

--

Go back
603.8379210259908, 1599.0740340196742
12.50098987744766, 6.336981303871471

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
603.420477588911, 1580.1756561954785
42.78795230067211, 81.08722578056317

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
621.3705453833396, 1632.915315239748
6.67909499327564, 7.031954539235825

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
805.875, 851.5
32.25, 45.0

IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2: IKK-alpha:IKK-beta:IKK-gamma

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p28

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false false false

--

Go back
742.875, 795.5
32.25, 45.0

IRAK-1{p}: IRAK-2: IRAK-4: TRFA6{ubK63}: Ubc13: Uev1: TAK1{activated}: TAB1: TAB2: MKK6

--

e64

cso30:c:Complex

cso30:i:CC_Cytosol

--

p30

p33

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
752.0, 1068.0
32.0, 32.0

NF-kappaB {activated}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31 p62 p65

p52 p63

true true true true

csml-variable:Double

m67

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
575.0, 731.0
25.0, 25.0

p38 {p}

--

e66

cso30:c:Protein

cso30:i:CC_CellComponent

--

p120 p81

p125

true true true true

csml-variable:Double

m68

10

false

infinite

0

unit false false false
TRANSPATHMO000000022

--

Go back
638.0, 862.0
32.0, 32.0

ERK {activated}

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33

--

true true true true

csml-variable:Double

m71

10

false

infinite

0

unit false false false
TRANSPATHMO000000011

--

Go back
1306.875, 589.5
32.25, 45.0

LPS: TLR4: MAL: MyD88

--

e68

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p34

p64 p71 p72 p73 p82

true true true true

csml-variable:Double

m72

0

false

infinite

0

unit false false false

--

Go back
278.875, 500.5
32.25, 45.0

Lp: TLR6: TLR2: MAL: MyD88

--

e69

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p35

--

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
272.53882698696657, 278.691741803597
948.2323613951371, 1414.6048428675685

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1094.875, 1084.5
27.238988805285373, 38.00789135621215

LPS: TLR4: TRAM

--

e70

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p36

p38

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
1150.875, 1130.5
28.114929344833914, 39.23013396953569

LPS: TLR4: TRAM: TRIF

--

e71

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p38

p42

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
1039.875, 1529.5
32.25, 45.0

dsRNA: TLR3: TRIF

--

e72

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p37

p44

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
1029.625, 1094.5
28.029453424429267, 34.321779703382774

LPS: TLR4

--

e73

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p36

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
1193.875, 1289.5
29.472242613323544, 41.12405946045146

LPS: TLR4: TRAM: TRIF: TRAF{activated}: TBK1

--

e74

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p43

p40

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
999.875, 1541.5
32.25, 45.0

dsRNA: TLR3: TRIF: TBK1

--

e75

cso30:c:Complex

cso30:i:CC_Cytosol

--

p44

p41

true true true true

csml-variable:Double

m79

0

false

infinite

0

unit false false false

--

Go back
1180.875, 1179.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TRAF3

--

e76

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p42

p39

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
1188.875, 1235.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF: TRAF3{activated}

--

e77

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p39

p43

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
1197.875, 1337.5
29.472242613323544, 41.12405946045146

LPS: TLR4: TRAM: TRIF: TRAF{activated}: TBK1{activated}

--

e78

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p40

p107

true true true true

csml-variable:Double

m82

0

false

infinite

0

unit false false false

--

Go back
943.875, 1437.5
32.25, 45.0

dsRNA: TLR3: TRIF: TBK1{activated}

--

e79

cso30:c:Complex

cso30:i:CC_Cytosol

--

p41

p108

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
275.9264852892569, 303.6581503366506
909.6506032054309, 1390.5917943680386

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
1303.5, 504.125
37.480000000000004, 28.11

MAL{membrane}

--

e80

cso30:c:Protein

cso30:i:CC_Extracellular

--

p46

p4 p7 p95

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
823.5, 1158.125
38.440000000000005, 28.83

TRAm{myristoylated}

--

e81

cso30:c:Protein

cso30:i:CC_Cytosol

--

p47

p49

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
1145.5, 461.125
33.64, 25.23

MAL{myristoylated}

--

e82

cso30:c:Protein

cso30:i:CC_Cytosol

--

p48 p95

p46

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
945.5, 1159.125
38.440000000000005, 28.83

TRAM{membrane}

--

e83

cso30:c:Protein

cso30:i:CC_Cytosol

--

p49

p45

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false false false

--

Go back
970.5, 1108.125
36.84, 27.629999999999995

TRAM{pS16}

--

e84

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

p45

p36

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false false false

--

Go back
483.5, 978.125
37.69470718454418, 23.245069430468906

SARM

--

e85

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p50

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false false false

--

Go back
426.625, 1031.5
30.919971671388097, 37.86118980169971

JNK3: SARM

--

e86

cso30:c:Complex

cso30:i:CC_Cytosol

--

p50

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false false false

--

Go back
703.5, 235.375
34.982425307557115, 22.738576449912127

TcpC

--

e87

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p51

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false false false

--

Go back
709.625, 434.5
28.739835027495417, 35.191634727545406

TcpC: MyD88

--

e88

cso30:c:Complex

cso30:i:CC_Cytosol

--

p51

p2 p34 p35

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false false false

--

Go back
128.5, 1383.25
45.0, 25.5

ATP

--

e89

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p54

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false false false

--

Go back
376.30166167058877, 328.6245588697041
905.4975492271566, 1372.3545314356763

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
359.625, 1380.5
29.499208465255787, 36.12147975337444

ATP: Nalp3

--

e90

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p54

p58 p60

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false false false

--

Go back
120.5, 1433.25
45.0, 25.5

silica

--

e91

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p55

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false false false

--

Go back
358.625, 1429.5
31.23025329111815, 38.24112647892018

silica: Nalp3

--

e92

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p55

--

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
423.0, 1575.0
26.0, 26.0

Nalp3{activated}

--

e93

cso30:c:Protein

cso30:i:CC_CellComponent

--

p57

--

true true true true

csml-variable:Double

m97

10

false

infinite

0

unit false false false
TRANSPATHMO000116924

--

Go back
189.5, 1481.0
26.254625052958623, 26.699618697924024

potassium{extracellular}

--

e94

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p56

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
361.5, 1481.0
26.254625052958623, 26.699618697924024

potassium

--

e95

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p56

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
183.0, 1239.0
39.5878889823381, 22.433137089991583

R837

--

e96

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p60

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
539.0, 1151.0
34.0, 34.0

Caspase-1

--

e97

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p60 p66 p67 p68

true true true true

csml-variable:Double

m101

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
1308.625, 850.5
32.520371604732546, 39.82086318946842

R837: TLR7

--

e98

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p61

true true true true

csml-variable:Double

m102

0

false

infinite

0

unit false false false

--

Go back
1304.875, 907.5
32.25, 45.0

R837: TLR7: MyD88

--

e99

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p61

p62

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
595.0, 231.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e5 MO000019395

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m6*m3962*0.1

nodelay

--

true

0

false

PMID: 18631453, 15795223 In brief, the model currently used to describe initiation of signaling involves ligand-induced dimerization of TLRs, creating a TIR-TIR interface, which acts to recruit adapters via their TIR domains.

Go back
191.0, 946.0
27.0, 27.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e25 MO000020434

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c29 : 1
stoichiometry:c30 : 1

m27*m4923*0.1

nodelay

--

true

0

false

PMID: 18631453, 17967410 NLRs that have been assigned functions include NOD1 and NOD2, which sense iE-DAP and MDP, respectively.

Go back
826.0, 1716.0
23.0, 23.0

p100

p100

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e126

G011948

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c297 : 1
stoichiometry:c296 : 1

m135*0.1

nodelay

--

true

0

false

PMID: 18631453 This leads to activation of STAT1 and, in turn, induction of SOCS1 and SOCS3, which act to block TLR signaling.

Go back
1027.0, 367.0
25.0, 25.0

p101

p101

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016884 e43

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c299 : 1
stoichiometry:c300 : 1

m1805*m45*0.1

nodelay

--

true

0

false

PMID: 18631453 The mechanism in both cases appears to be SHP1 binding to the kinase domain of IRAK-1 (which contains several phosphoaccepting tyrosines), where it inhibits its activity.

Go back
1141.0, 204.0
25.0, 25.0

p102

p102

cso30:i:ME_UnknownDegradation

cso30:i:CC_Extracellular

--

e127

MO000019479 e128 MO000016884

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c302 : 1
stoichiometry:c303 : 1
stoichiometry:c304 : 1

m136*0.1

nodelay

--

true

0

false

PMID: 18631453, 18391954 This kinase activity is required for induction of proinflammatory cytokines, but is somehow inhibitory for induction of type I interferons, because autophosphoylation of IRAK1 leads to its degradation, allowing for increased production of type I interferons.

Go back
584.0, 1603.0
27.0, 27.0

p103

p103

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c307 : 1
stoichiometry:c305 : 1

m45*0.1

nodelay

--

true

0

false

PMID: 18631453, 18391954 This kinase activity is required for induction of proinflammatory cytokines, but is somehow inhibitory for induction of type I interferons, because autophosphoylation of IRAK1 leads to its degradation, allowing for increased production of type I interferons.

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647.0, 1624.0
25.0, 25.0

p104

p104

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

e129

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c308 : 1
stoichiometry:c306 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18631453, 18391954 This kinase activity is required for induction of proinflammatory cytokines, but is somehow inhibitory for induction of type I interferons, because autophosphoylation of IRAK1 leads to its degradation, allowing for increased production of type I interferons.

Go back
642.0, 1818.0
27.0, 27.0

p105

p105

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e127 e129

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c309 : 1
stoichiometry:c310 : 1
stoichiometry:c311 : 1

m136*m138*0.1

nodelay

--

true

0

false

PMID: 18631453 Intriguingly, SHP1 promotes production of type I interferons by TLRs and also RIG-I.

Go back
573.0, 1789.0
27.0, 27.0

p106

p106

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e129 e130 MO000016884

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c313 : 1
stoichiometry:c314 : 1
stoichiometry:c315 : 1
stoichiometry:c312 : 1

m138*m139*m1805*0.1

nodelay

--

true

0

false

PMID: 18631453 Intriguingly, SHP1 promotes production of type I interferons by TLRs and also RIG-I.

Go back
903.0, 1347.0
25.0, 25.0

p107

p107

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e78

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c320 : 1
stoichiometry:c324 : 1
stoichiometry:c321 : 1

m977*m82*0.1

nodelay

--

true

0

false

PMID: 18631453 In this case, SHP2 was shown to target TBK-1, the kinase that phosphorylates IRF3.

Go back
904.0, 1388.0
23.0, 23.0

p108

p108

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e79

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c325 : 1
stoichiometry:c323 : 1

m977*m83*0.1

nodelay

--

true

0

false

PMID: 18631453 In this case, SHP2 was shown to target TBK-1, the kinase that phosphorylates IRF3.

Go back
683.0, 1839.0
25.0, 25.0

p109

p109

cso30:i:ME_Translation

cso30:i:CC_Extracellular

--

G010228 e127

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c329 : 1
stoichiometry:c330 : 1
stoichiometry:c328 : 1

m93217*m136*0.1

nodelay

--

true

0

false

PMID: 18631453 Although related, therefore, SHP1 and SHP2 have opposite effects. SHP1 promotes interferon-¦Â production in response to TLRs, whereas SHP2 is inhibitory.

Go back
188.0, 1042.0
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000020461 e26

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c31 : 1
stoichiometry:c33 : 1
stoichiometry:c32 : 1

m4947*m28*0.1

nodelay

--

true

0

false

PMID: 18631453, 17967410 NLRs that have been assigned functions include NOD1 and NOD2, which sense iE-DAP and MDP, respectively.

Go back
711.0, 1627.0
25.0, 25.0

p110

p110

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456 MO000016886

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c332 : 1
stoichiometry:c335 : 1
stoichiometry:c331 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18631453 SHP2 limits TLR3-induced production of proinflammatory cytokines and interferon-beta, without affecting TLR2 or TLR9 signaling.

Go back
648.0, 1588.0
23.0, 23.0

p111

p111

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

MO000041456 MO000016886

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c333 : 1
stoichiometry:c336 : 1
stoichiometry:c334 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18631453 SHP2 limits TLR3-induced production of proinflammatory cytokines and interferon-beta, without affecting TLR2 or TLR9 signaling.

Go back
397.0, 345.0
24.0, 24.0

p112

p112

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

MO000016573 e131

e132

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c337 : 1
stoichiometry:c338 : 1
stoichiometry:c339 : 1

m1572*m140*0.1

nodelay

--

true

0

false

PMID: 18631453 In IL-1 signaling, MyD88 is recruited to the receptor complex within seconds, where it stably associates.

Go back
1403.0, 1439.0
25.0, 25.0

p113

p113

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016566 e19

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c340 : 1
stoichiometry:c341 : 1
stoichiometry:c342 : 1

m1569*m21*0.1

nodelay

--

true

0

false

PMID: 18631453 For TLR3, IRAK2 is directly recruited.

Go back
561.0, 565.0
23.0, 23.0

p114

p114

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e135

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c353 : 1
stoichiometry:c354 : 1

m69*0.1

nodelay

--

true

0

false

PMID: 18631453 Importantly, their activity is greatly enhanced, at least in vitro, in response to phosphorylation by IRAK1 and IRAK4.

Go back
875.0, 211.0
25.0, 25.0

p115

p115

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

e41

e134

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1

m43*0.1

nodelay

--

true

0

false

PMID: 18631453 It was shown that similar to IRAK1, IRAK2 was activated downstream of IRAK4.

Go back
1095.0, 627.0
25.0, 25.0

p116

p116

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000000212 MO000016591

e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c346 : 1
stoichiometry:c347 : 1
stoichiometry:c348 : 1

m183*m1585*0.1

nodelay

--

true

0

false

PMID: 18631453 A20 is a key ubiquitin-editing enzyme that restricts TLR responses by regulating the ubiquitination of key signaling proteins such as Traf6.

Go back
708.0, 552.0
25.0, 25.0

p117

p117

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 MO000041419 MO000041433

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c349 : 1
stoichiometry:c350 : 1
stoichiometry:c351 : 1
stoichiometry:c352 : 1

m47*m19287*m19301*0.1

nodelay

--

true

0

false

pMID: 18631453, 17675297, 17997719 Two proteins, termed Pellino-1 and Pellino-3b, appear to be important in this process. These proteins were known to interact with IRAK-1, and recent studies indicate that similar to Traf6, they are E3 ligases.

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443.0, 579.0
25.0, 25.0

p118

p118

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e137

e138

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c355 : 1
stoichiometry:c356 : 1

m144*0.1

nodelay

--

true

0

false

PMID: 18631453 The role of the kinase activity of IRAK1 and/or IRAK4 might therefore be at least initially to activate Pellinos, such that they can cause K63-linked polyubiquitination of IRAK1.

Go back
442.0, 642.0
26.0, 26.0

p119

p119

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e138 MO000016599

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c357 : 1
stoichiometry:c358 : 1
stoichiometry:c359 : 1

m146*m1593*0.1

nodelay

--

true

0

false

PMID: 18631453 Most interestingly, this recruits NEMO to IRAK1, with NEMO binding to polyubiquitin.

Go back
190.0, 1157.0
25.0, 25.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e26 MO000116924

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1
stoichiometry:c36 : 1

m28*m86033*0.1

nodelay

--

true

0

false

PMID: 18631453, 15530394, 16407889, 18403674 In addition, Nalp3 (also called Cryopyrin of Nlrp3) senses multiple pathogens, pathogen products such as MDP, and products of damaged cells such as uric acid crystals and exogenous crystals such as asbestos.

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642.0, 726.0
27.0, 27.0

p120

p120

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 e32 e127

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c360 : 1
stoichiometry:c362 : 1
stoichiometry:c363 : 1
stoichiometry:c361 : 1

m20*m34*0.1

nodelay

--

true

0

false

PMID: 18631453 These ultimately trigger NF-kappaB, p38, and ERK activation. PMID: 18631453, 18391954 It has been shown that SHP1 negatively regulates TLR-mediated production of proinflammatory cytokines by inhibiting activation of NF-kappaB and MAP kinases.

Go back
769.0, 521.0
29.0, 29.0

p121

p121

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e44

e141

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c318 : 1
stoichiometry:c364 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 18631453 There is also evidence that TRAF6 ubiquitinates IRAK1.

Go back
1181.0, 877.0
30.0, 30.0

p122

p122

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e147

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c389 : 1
stoichiometry:c367 : 1

m155*0.1

nodelay

--

true

0

false

PMID: 18631453, 18345001 In the second study, a protein termed TRIM30-alpha, which has a RING finger (often indicative of E3 ubiquitin ligase activity) was shown to limit TLR signaling by targeting TAB2 and TAB3, causing their degradation. This effect was not via the ubiquitin-proteasome pathway, however, but depended on lysosomal degradation.

Go back
1148.0, 836.0
31.0, 31.0

p123

p123

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e146

MO000019479

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c388 : 1
stoichiometry:c368 : 1

m154*0.1

nodelay

--

true

0

false

PMID: 18631453, 18345001 In the second study, a protein termed TRIM30-alpha, which has a RING finger (often indicative of E3 ubiquitin ligase activity) was shown to limit TLR signaling by targeting TAB2 and TAB3, causing their degradation. This effect was not via the ubiquitin-proteasome pathway, however, but depended on lysosomal degradation.

Go back
576.0, 1524.0
23.0, 23.0

p124

p124

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000021732

G011404

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c372 : 1
stoichiometry:c371 : 1

m6069*0.1

nodelay

--

true

0

false

PMID: 18631453, 12391149, 16880258, 16380513 The mechanism was shown to involve induction of a phosphatase termed MKP-1 which dephosphorylates p38 and thereby inactivates it.

Go back
506.0, 670.0
27.0, 27.0

p125

p125

cso30:i:ME_Dephosphorylation

cso30:i:CC_Cytosol

--

e66 G011404

MO000000022

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c373 : 1
stoichiometry:c375 : 1
stoichiometry:c374 : 1

m68*m94283*0.1

nodelay

--

true

0

false

PMID: 18631453, 12391149, 16880258, 16380513 The mechanism was shown to involve induction of a phosphatase termed MKP-1 which dephosphorylates p38 and thereby inactivates it.

Go back
930.0, 1620.0
23.0, 23.0

p126

p126

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e143 MO000074564

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c377 : 1
stoichiometry:c379 : 1
stoichiometry:c378 : 1

m151*m49366*0.1

nodelay

--

true

0

false

PMID: 18631453 GRIP1 is a protein that interacts with the glucocorticoid receptor.

Go back
787.0, 1387.0
25.0, 25.0

p127

p127

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041456 MO000074564 e144

e145

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c380 : 1
stoichiometry:c381 : 1
stoichiometry:c383 : 1
stoichiometry:c382 : 1

m19324*m49366*0.1

nodelay

--

true

0

false

PMID: 18631453 A yeast two-hybrid screen isolated IRF3 as an interacting protein, and it was shown that GRIP1 was required for IRF3-mediated transactivation. PMID: 18631453, 16362036 Importantly the glucocorticoid receptor competed with IRF3 for GRIP1 and thereby blocked IRF3-mediated gene expression.

Go back
741.0, 1513.0
27.0, 27.0

p128

p128

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e145 e144

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c384 : 1
stoichiometry:c385 : 1

m153*0.1

nodelay

--

true

0

false

PMID: 18631453, 16362036 Importantly the glucocorticoid receptor competed with IRF3 for GRIP1 and thereby blocked IRF3-mediated gene expression.

Go back
1124.0, 740.0
23.0, 23.0

p129

p129

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000016588 e142

e146

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c365 : 1
stoichiometry:c391 : 1
stoichiometry:c366 : 1

m1583*m150*0.1

nodelay

--

true

0

false

PMID: 18631453, 18345001 In the second study, a protein termed TRIM30-alpha, which has a RING finger (often indicative of E3 ubiquitin ligase activity) was shown to limit TLR signaling by targeting TAB2 and TAB3, causing their degradation.

Go back
196.0, 1278.0
27.0, 27.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000116924 e29

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c37 : 1
stoichiometry:c38 : 1
stoichiometry:c39 : 1

m86033*m31*0.1

nodelay

--

true

0

false

PMID: 18631453, 15530394, 16407889, 18403674 In addition, Nalp3 (also called Cryopyrin of Nlrp3) senses multiple pathogens, pathogen products such as MDP, and products of damaged cells such as uric acid crystals and exogenous crystals such as asbestos.

Go back
1137.0, 785.0
21.0, 21.0

p130

p130

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

MO000022125 e142

e147

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c386 : 1
stoichiometry:c390 : 1
stoichiometry:c387 : 1

m6433*m150*0.1

nodelay

--

true

0

false

PMID: 18631453, 18345001 In the second study, a protein termed TRIM30-alpha, which has a RING finger (often indicative of E3 ubiquitin ligase activity) was shown to limit TLR signaling by targeting TAB2 and TAB3, causing their degradation.

Go back
192.0, 1330.0
27.0, 27.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000116924 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c40 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m86033*m35*0.1

nodelay

--

true

0

false

PMID: 18631453, 15530394, 16407889, 18403674 In addition, Nalp3 (also called Cryopyrin of Nlrp3) senses multiple pathogens, pathogen products such as MDP, and products of damaged cells such as uric acid crystals and exogenous crystals such as asbestos.

Go back
230.0, 1708.0
27.0, 27.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e36 e35

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m38*m37*0.1

nodelay

--

true

0

false

PMID: 18631453, 15208624, 12163569 The best-known RLR is RIG-I, which senses single-stranded RNA found in viruses, and the best known CLR is Dectin-1, which senses beta-glucan, found in fungal cell walls.

Go back
418.0, 1967.0
25.0, 25.0

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019656 e38

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m4193*m40*0.1

nodelay

--

true

0

false

PMID: 18631453, 15208624, 12163569 The best-known RLR is RIG-I, which senses single-stranded RNA found in viruses, and the best known CLR is Dectin-1, which senses beta-glucan, found in fungal cell walls.

Go back
648.0, 232.0
24.0, 24.0

p17

p17

cso30:i:ME_Dimerization

cso30:i:CC_Extracellular

--

e6

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c6 : 1
stoichiometry:c49 : 1

m11*0.1

nodelay

--

true

0

false

PMID: 18631453, 15795223 In brief, the model currently used to describe initiation of signaling involves ligand-induced dimerization of TLRs, creating a TIR-TIR interface, which acts to recruit adapters via their TIR domains.

Go back
907.0, 395.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 e11 MO000039077 MO000016566

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c343 : 1
stoichiometry:c54 : 1

m184*m12*m17258*m1569*0.1

nodelay

--

true

0

false

PMID: 18631453 This in turn leads to the recruitment of IRAK1 and IRAK4. PMID: 18631453 IRAK4 and IRAK1 (and probably IRAK2) are then recruited to MyD88.

Go back
942.0, 202.0
27.0, 27.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e134

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c344 : 1

m143*0.1

nodelay

--

true

0

false

PMID: 18631453 IRAK4 then activates IRAK1, allowing IRAK1 to autophosphorylate.

Go back
759.0, 415.0
26.0, 26.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e40 e88

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c50 : 1
stoichiometry:c147 : 1
stoichiometry:c5 : 1

m1572*m42*0.1

nodelay

--

true

0

false

PMID: 18631453 MyD88 is the universal adaptor, used by all TLRs except TLR3, and acts to recruit the IRAK family of kinases. PMID: 18631453, 18327267 A uropathogenic strain of E. coli, termed CFT073, was then shown to have a TIR-domain-containing protein termed TIR-containing protein C (TcpC). The bacteria release this protein, which is somehow taken up by macrophages, where it interacts with MyD88 to prevent signaling.

Go back
890.0, 486.0
27.0, 27.0

p20

p20

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e43

e11 e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c59 : 1
stoichiometry:c60 : 1
stoichiometry:c61 : 1

m45*0.1

nodelay

--

true

0

false

PMID; 18631453 Both IRAK1 and IRAK4 then dissociate from MyD88, which remains in a complex with the activated receptor¡½this has been shown for IL-1RI and will most probably apply to the TLRs. PMID: 18631453 IRAK4 then phosphorylates IRAK1, and the kinases dissociate from MyD88.

Go back
1005.0, 209.0
29.0, 29.0

p21

p21

cso30:i:ME_Autophosphorylation

cso30:i:CC_Cytosol

--

e42

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c345 : 1
stoichiometry:c58 : 1

m44*0.1

nodelay

--

true

0

false

PMID: 18631453 IRAK4 then activates IRAK1, allowing IRAK1 to autophosphorylate.

Go back
942.5, 594.0
25.5, 25.5

p22

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e45 MO000000212

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c62 : 1
stoichiometry:c63 : 1
stoichiometry:c64 : 1

m47*m183*0.1

nodelay

--

true

0

false

PMID: 18631453 They in turn interact with TRAF6, which is an E3 ubiquitin ligase. PMID: 18631453 IRAK2 leads to K63-linked polyubiquitination of TRAF6, which serves as a platform to recruit TAK1. PMID: 18631453 IRAK1 has a similar role to IRAK2¡½it leads to K63-linked polyubiquitination of TRAF6 and TAK1 recruitment.

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1004.0, 659.0
30.0, 30.0

p23

p23

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e47

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m49*0.1

nodelay

--

true

0

false

PMID: 18361453 TRAF6 is then thought to autoubiquinate, attaching K63-polyubiquitin to itself. PMID: 18631453 IRAK2 leads to K63-linked polyubiquitination of TRAF6, which serves as a platform to recruit TAK1. PMID: 18631453 IRAK1 has a similar role to IRAK2¡½it leads to K63-linked polyubiquitination of TRAF6 and TAK1 recruitment.

Go back
878.0, 661.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000022136 MO000022139 e44

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c68 : 1
stoichiometry:c69 : 1
stoichiometry:c71 : 1
stoichiometry:c70 : 1

m6443*m6446*m46*0.1

nodelay

--

true

0

false

PMID: 18631453, 11057907 The E2-conjugating complexes Ubc13 and Uev1a are also involved in this process.

Go back
998.0, 714.0
27.0, 27.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e46 MO000016574 MO000016588 MO000022125

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c72 : 1

m48*m1573*m1583*m6433*0.1

nodelay

--

true

0

false

PMID: 18631453 K63-polyubiquitin-TRAF6 can then recruit TAK1 in a complex with TAB2 and TAB3, which both contain nuclear zinc-finger motifs that interact with K63-polyubiquitin chains.

Go back
952.0, 798.0
27.0, 27.0

p26

p26

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e48

e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c76 : 1
stoichiometry:c77 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 18631453 This somehow activates TAK1, which then couples to the IKK complex, which contains the scaffold protein NEMO and the kinase responsible for phosphorylation of I-kappaB, IKK2.

Go back
901.0, 860.0
27.0, 27.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000016661

e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c78 : 1
stoichiometry:c79 : 1
stoichiometry:c80 : 1

m64*m1637*0.1

nodelay

--

true

0

false

PMID: 18631453 This somehow activates TAK1, which then couples to the IKK complex, which contains the scaffold protein NEMO and the kinase responsible for phosphorylation of I-kappaB, IKK2.

Go back
811.0, 927.0
25.0, 25.0

p28

p28

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000233 e63

MO000000220

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c81 : 1
stoichiometry:c83 : 1
stoichiometry:c82 : 1

m199*m65*0.1

nodelay

--

true

0

false

PMID: 18631453 This somehow activates TAK1, which then couples to the IKK complex, which contains the scaffold protein NEMO and the kinase responsible for phosphorylation of I-kappaB, IKK2.

Go back
799.0, 727.0
25.0, 25.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000016966

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c84 : 1
stoichiometry:c87 : 1
stoichiometry:c86 : 1

m64*m1875*0.1

nodelay

--

true

0

false

PMID: 18631453 TAK1 also couples to MKK3-MKK6 and MKK7, the respective upstream kinases for p38 and JNK.

Go back
1390.0, 425.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 MO000016882

e12

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m3961*m155666*0.1

nodelay

--

true

0

false

PMID: 18631453 The best characterized are TLR2, which in combination with TLR1 or TLR6 can recognize acylated lipopeptides; TLR3, which senses double-stranded RNA; TLR4, which senses LPS; and TLR9, which senses hypomethylated CpG motifs.

Go back
817.0, 796.0
27.0, 27.0

p30

p30

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e49 MO000019005

e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c88 : 1
stoichiometry:c89 : 1

m64*m3613*0.1

nodelay

--

true

0

false

PMID: 18631453 TAK1 also couples to MKK3-MKK6 and MKK7, the respective upstream kinases for p38 and JNK.

Go back
714.0, 1014.0
27.0, 27.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 MO000000220 e108 e120 e127

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c90 : 1
stoichiometry:c92 : 1
stoichiometry:c249 : 1
stoichiometry:c275 : 1
stoichiometry:c316 : 1
stoichiometry:c91 : 1

m5*m190*m113*0.1

nodelay

--

true

0

false

PMID: 18631453 These ultimately trigger NF-kappaB, p38, and ERK activation. PMID: 18631453 It might involve activation of PI3 kinase, which via Akt has been shown to block NF-kappaB activation by TLR4. PMID: 18631453, 18391954 It has been shown that SHP1 negatively regulates TLR-mediated production of proinflammatory cytokines by inhibiting activation of NF-kappaB and MAP kinases.

Go back
622.0, 606.0
27.0, 27.0

p32

p32

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

e138

MO000019479 e140

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c93 : 1
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m146*0.1

nodelay

--

true

0

false

PMID: 18631453 Ultimately, both IRAK1 and the Pellinos (which also undergo ubiquitination) are probably degraded to terminate the signal.

Go back
680.0, 803.0
29.0, 29.0

p33

p33

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64 MO000000011 e127

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c96 : 1
stoichiometry:c97 : 1
stoichiometry:c319 : 1
stoichiometry:c98 : 1

m66*m70*0.1

nodelay

--

true

0

false

PMID: 18631453 These ultimately trigger NF-kappaB, p38, and ERK activation. PMID: 18631453, 18391954 It has been shown that SHP1 negatively regulates TLR-mediated production of proinflammatory cytokines by inhibiting activation of NF-kappaB and MAP kinases.

Go back
1116.0, 556.0
23.0, 23.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e13 MO000016573 e88

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c148 : 1
stoichiometry:c104 : 1

m14*m1572*0.1

nodelay

--

true

0

false

PMID: 18631453 MyD88 adaptor-like (Mal, also called TIRAP) is recruited by TLR2 and TLR4, and so far its main function appears to be to subsequently stabilize MyD88 in the complex, acting as a bridge. PMID: 18631453, 18327267 A uropathogenic strain of E. coli, termed CFT073, was then shown to have a TIR-domain-containing protein termed TIR-containing protein C (TcpC). The bacteria release this protein, which is somehow taken up by macrophages, where it interacts with MyD88 to prevent signaling.

Go back
205.0, 509.0
27.0, 27.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 e18 e88

e69

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c101 : 1
stoichiometry:c102 : 1
stoichiometry:c149 : 1
stoichiometry:c103 : 1

m1572*m19*0.1

nodelay

--

true

0

false

PMID: 18631453 MyD88 adaptor-like (Mal, also called TIRAP) is recruited by TLR2 and TLR4, and so far its main function appears to be to subsequently stabilize MyD88 in the complex, acting as a bridge. PMID: 18631453, 18327267 A uropathogenic strain of E. coli, termed CFT073, was then shown to have a TIR-domain-containing protein termed TIR-containing protein C (TcpC). The bacteria release this protein, which is somehow taken up by macrophages, where it interacts with MyD88 to prevent signaling.

Go back
1030.0, 1030.0
27.0, 27.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e73 e84

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c105 : 1
stoichiometry:c140 : 1
stoichiometry:c107 : 1

m77*m88*0.1

nodelay

--

true

0

false

PMID: 18631453 Trif is used by TLR3 and also TLR4, but in the case of TLR4 another bridging adaptor is needed, Tram. PMID: 18631453 TLR4 in endosomes recruits TRAM and TRIF, leading to TRAF3 activation.

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999.0, 1419.0
25.0, 25.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000041125 e19

e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m18998*m21*0.1

nodelay

--

true

0

false

PMID: 18631453 Trif is used by TLR3 and also TLR4, but in the case of TLR4 another bridging adaptor is needed, Tram.

Go back
1037.0, 1138.0
23.0, 23.0

p38

p38

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e70 MO000041125

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c108 : 1
stoichiometry:c110 : 1
stoichiometry:c109 : 1

m74*m18998*0.1

nodelay

--

true

0

false

PMID: 18631453 Trif is used by TLR3 and also TLR4, but in the case of TLR4 another bridging adaptor is needed, Tram. PMID: 18631453 TLR4 in endosomes recruits TRAM and TRIF, leading to TRAF3 activation.

Go back
1236.0, 1191.0
25.0, 25.0

p39

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e76

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c115 : 1

m80*0.1

nodelay

--

true

0

false

PMID: 18631453 TLR4 in endosomes recruits TRAM and TRIF, leading to TRAF3 activation.

Go back
1374.0, 553.0
25.0, 25.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e12 e80

e13

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c11 : 1
stoichiometry:c130 : 1
stoichiometry:c12 : 1

m13*m84*0.1

nodelay

--

true

0

false

PMID: 18631453 MyD88 adaptor-like (Mal, also called TIRAP) is recruited by TLR2 and TLR4, and so far its main function appears to be to subsequently stabilize MyD88 in the complex, acting as a bridge.

Go back
1115.0, 1331.0
25.0, 25.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e74 MO000016886 MO000021732

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c125 : 1
stoichiometry:c326 : 1
stoichiometry:c376 : 1
stoichiometry:c126 : 1

m78*0.1

nodelay

--

true

0

false

PMID: 18631453, 18222170, 18297073 Trif leads to IRF3 activation via recruitment of the kinase TBK-1, and this signal, in the case of both TLR3 and TLR4, comes from the endosome, with TLR4 trafficking there after LPS recognition. PMID: 18631453 In this case, SHP2 was shown to target TBK-1, the kinase that phosphorylates IRF3. PMID: 18631453, 18356163 In addition, another study has shown that activation of TBK-1, the upstream kinase for IRF3, is inhibited by glucocorticoids, again pointing to a more general mechanism rather than inhibition of TLR4 specifically.

Go back
948.0, 1544.0
23.0, 23.0

p41

p41

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e75 MO000016886

e79

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c121 : 1
stoichiometry:c327 : 1
stoichiometry:c128 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 18631453, 18222170, 18297073 Trif leads to IRF3 activation via recruitment of the kinase TBK-1, and this signal, in the case of both TLR3 and TLR4, comes from the endosome, with TLR4 trafficking there after LPS recognition. PMID: 18631453 In this case, SHP2 was shown to target TBK-1, the kinase that phosphorylates IRF3.

Go back
1103.0, 1188.0
27.0, 27.0

p42

p42

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e71 MO000016963

e76

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c116 : 1
stoichiometry:c123 : 1
stoichiometry:c122 : 1

m75*m1872*0.1

nodelay

--

true

0

false

PMID: 18631453 TLR4 will then traffic to endosomes, where TRAM is now engaged, recruiting TRIF, which in turn recruits TRAF3 to activate TBK-1.

Go back
1106.0, 1287.0
27.0, 27.0

p43

p43

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e77 MO000019331

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1

m81*m3902*0.1

nodelay

--

true

0

false

PMID: 18631453, 18222170, 18297073 Trif leads to IRF3 activation via recruitment of the kinase TBK-1, and this signal, in the case of both TLR3 and TLR4, comes from the endosome, with TLR4 trafficking there after LPS recognition.

Go back
1050.0, 1374.0
27.0, 27.0

p44

p44

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000019331 e72

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c120 : 1
stoichiometry:c124 : 1
stoichiometry:c127 : 1

m3902*m76*0.1

nodelay

--

true

0

false

PMID: 18631453, 18222170, 18297073 Trif leads to IRF3 activation via recruitment of the kinase TBK-1, and this signal, in the case of both TLR3 and TLR4, comes from the endosome, with TLR4 trafficking there after LPS recognition.

Go back
894.0, 1109.0
25.0, 25.0

p45

p45

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000016645 e83

e84

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c129 : 1
stoichiometry:c106 : 1
stoichiometry:c139 : 1

m1629*m87*0.1

nodelay

--

true

0

false

PMID: 18631453, 16757566 Phosphorylation of TRAM on serine 16 by protein kinase C-epsilon is required for this process and may be required for endosomal trafficking or displacement of Mal-MyD88 from the complex.

Go back
1151.0, 507.0
21.0, 21.0

p46

p46

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e82

e80

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c136 : 1
stoichiometry:c10 : 1

m86*0.1

nodelay

--

true

0

false

PIMD: 18631453, 16751103, 16603631 Mal has a phosphatidylinositol-4,5-bisphosphase (PIP2) binding domain that localizes it to the plasma membrane, whereas TRAM is myristoylated for the same reason.

Go back
830.0, 1213.0
25.0, 25.0

p47

p47

cso30:i:ME_Myristoylation

cso30:i:CC_Cytosol

--

MO000041132

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c133 : 1
stoichiometry:c134 : 1

m19005*0.1

nodelay

--

true

0

false

PIMD: 18631453, 16751103, 16603631 Mal has a phosphatidylinositol-4,5-bisphosphase (PIP2) binding domain that localizes it to the plasma membrane, whereas TRAM is myristoylated for the same reason.

Go back
1146.0, 398.0
31.0, 31.0

p48

p48

cso30:i:ME_Myristoylation

cso30:i:CC_Cytosol

--

MO000068831 MO000000331

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c135 : 1
stoichiometry:c131 : 1

m43675*m290229*0.1

nodelay

--

true

0

false

PIMD: 18631453, 16751103, 16603631 Mal has a phosphatidylinositol-4,5-bisphosphase (PIP2) binding domain that localizes it to the plasma membrane, whereas TRAM is myristoylated for the same reason.

Go back
886.0, 1161.0
25.0, 25.0

p49

p49

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e81

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m85*0.1

nodelay

--

true

0

false

PIMD: 18631453, 16751103, 16603631 Mal has a phosphatidylinositol-4,5-bisphosphase (PIP2) binding domain that localizes it to the plasma membrane, whereas TRAM is myristoylated for the same reason.

Go back
213.0, 405.0
27.0, 27.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e15 MO000017793

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c15 : 1
stoichiometry:c18 : 1
stoichiometry:c16 : 1

m16*m2549*0.1

nodelay

--

true

0

false

PMID: 18631453 The best characterized are TLR2, which in combination with TLR1 or TLR6 can recognize acylated lipopeptides; TLR3, which senses double-stranded RNA; TLR4, which senses LPS; and TLR9, which senses hypomethylated CpG motifs.

Go back
489.0, 1037.0
26.0, 26.0

p50

p50

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017818 e85

e86

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c141 : 1
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m2570*m89*0.1

nodelay

--

true

0

false

PMID: 18631453, 17724133 It has also been shown to be expressed in neurons, where it interacts with the MAP kinase JNK3.

Go back
708.0, 327.0
27.0, 27.0

p51

p51

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e87 MO000016573

e88

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c144 : 1
stoichiometry:c145 : 1
stoichiometry:c146 : 1

m91*m1572*0.1

nodelay

--

true

0

false

PMID: 18631453, 18327267 A uropathogenic strain of E. coli, termed CFT073, was then shown to have a TIR-domain-containing protein termed TIR-containing protein C (TcpC). The bacteria release this protein, which is somehow taken up by macrophages, where it interacts with MyD88 to prevent signaling.

Go back
717.0, 1361.0
29.0, 29.0

p52

p52

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010389 e65

MO000019449

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c155 : 1
stoichiometry:c151 : 1

m93364*m67*0.1

nodelay

--

true

0

false

PMID: 18631453 A clear-cut example of this ¡Ètwo-signal¡É approach is the ability of TLRs to induce pro-IL-1beta production, but without causing processing to the mature cytokine, as shown in Figure 1.

Go back
607.0, 1278.0
30.0, 30.0

p53

p53

cso30:i:ME_ProteinCleavage

cso30:i:CC_Cytosol

--

MO000019449 MO000016828

MO000016597

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c154 : 1
stoichiometry:c153 : 1

m4012*m1765*0.1

nodelay

--

true

0

false

PMID: 18631453 Various stimuli act via Nalp3 to activate caspase-1, which processes the pro-IL-1beta protein into mature IL-1beta.

Go back
191.0, 1388.0
23.0, 23.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000116924 e89

e90

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c156 : 1
stoichiometry:c157 : 1
stoichiometry:c158 : 1

m86033*m93*0.1

nodelay

--

true

0

false

PMID: 18631453, 15530394, 16407889, 18403674 Nalp3 is a key component of an important caspase-1-containing inflammasome and is activated by various pathogens; such substances as ATP, MDP and, most recently, other types of crystals such as asbestos and silica.

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191.0, 1438.0
23.0, 23.0

p55

p55

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000116924 e91

e92

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c160 : 1
stoichiometry:c161 : 1

m86033*m95*0.1

nodelay

--

true

0

false

PMID: 18631453, 15530394, 16407889, 18403674 Nalp3 is a key component of an important caspase-1-containing inflammasome and is activated by various pathogens; such substances as ATP, MDP and, most recently, other types of crystals such as asbestos and silica.

Go back
293.5, 1481.0
26.5, 26.5

p56

p56

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e95 MO000064988 MO000063086

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c164 : 1
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c165 : 1

m99*m39857*m37969*0.1

nodelay

--

true

0

false

PMID: 18631453, 17433728 The mechanism of Nalp3 activation has been shown to involve a potassium efflux, mediated by the P2X7 receptor in combination with the ion channel pannexin-1.

Go back
422.0, 1529.0
25.0, 25.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000116924 MO000063086 MO000064988 MO000008272

e93

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c168 : 1
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c163 : 1

m86033*m37969*m39857*m1063*0.1

nodelay

--

true

0

false

PMID: 18631453, 17433728 The mechanism of Nalp3 activation has been shown to involve a potassium efflux, mediated by the P2X7 receptor in combination with the ion channel pannexin-1. PMID: 18631453 It also appears to involve reactive oxygen species (ROS) generated by the NADPH oxidase, although how the potassium efflux or ROS generation leads to Nalp3 activation is not known.

Go back
450.0, 1190.0
27.0, 27.0

p58

p58

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e97 MO000016882 e90

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c176 : 1
stoichiometry:c175 : 1
stoichiometry:c174 : 1

m101*m155666*m94*0.1

nodelay

--

true

0

false

PMID: 18631453 TLR ligands such as LPS or the TLR7 ligand R837 also modulate the inflammasome, enabling ATP to activate caspase-1 via Nalp3.

Go back
494.0, 1485.0
25.0, 25.0

p59

p59

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000021432 e31

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c206 : 1
stoichiometry:c173 : 1

m5783*m33*0.1

nodelay

--

true

0

false

PMID: 18631453 It also appears to involve reactive oxygen species (ROS) generated by the NADPH oxidase, although how the potassium efflux or ROS generation leads to Nalp3 activation is not known. PMID: 18631453 Uric acid and asbestos have been shown to activate NADPH-oxidase-generating reactive oxygen species (ROS), which are also required for Nalp3 activation, although again a mechanism is missing.

Go back
217.0, 285.0
27.0, 27.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e14 MO000017793

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c17 : 1
stoichiometry:c14 : 1

m15*m2549*0.1

nodelay

--

true

0

false

PMID: 18631453 The best characterized are TLR2, which in combination with TLR1 or TLR6 can recognize acylated lipopeptides; TLR3, which senses double-stranded RNA; TLR4, which senses LPS; and TLR9, which senses hypomethylated CpG motifs.

Go back
451.0, 1235.0
25.0, 25.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e97 e90 e96

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1
stoichiometry:c178 : 1

m101*m94*m100*0.1

nodelay

--

true

0

false

PMID: 18631453 TLR ligands such as LPS or the TLR7 ligand R837 also modulate the inflammasome, enabling ATP to activate caspase-1 via Nalp3.

Go back
1395.0, 856.0
27.0, 27.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m1572*m102*0.1

nodelay

--

true

0

false

PMID: 18631453 TLRs such as TLR4 and TLR7 activate the standard signaling pathway via MyD88 and NF-kappaB to induce pro-IL-1beta mRNA.

Go back
846.0, 1070.0
27.0, 27.0

p62

p62

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e99 e127

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c184 : 1
stoichiometry:c186 : 1
stoichiometry:c317 : 1
stoichiometry:c185 : 1

m5*m103*0.1

nodelay

--

true

0

false

PMID: 18631453 TLRs such as TLR4 and TLR7 activate the standard signaling pathway via MyD88 and NF-kappaB to induce pro-IL-1beta mRNA. PMID: 18631453, 18391954 It has been shown that SHP1 negatively regulates TLR-mediated production of proinflammatory cytokines by inhibiting activation of NF-kappaB and MAP kinases.

Go back
656.0, 1466.0
27.0, 27.0

p63

p63

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

G010389

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c188 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18631453 TLRs such as TLR4 and TLR7 activate the standard signaling pathway via MyD88 and NF-kappaB to induce pro-IL-1beta mRNA.

Go back
1202.0, 594.0
27.0, 27.0

p64

p64

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000212 e68

e100

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c189 : 1
stoichiometry:c191 : 1
stoichiometry:c190 : 1

m183*m72*0.1

nodelay

--

true

0

false

PMID: 18631453 TLR4 in the plasma membrane engages with Mal and subsequently MyD88, for NF-kappaB activation via TRAF6.

Go back
850.0, 1013.0
25.0, 25.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000058 e100 e120

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c192 : 1
stoichiometry:c194 : 1
stoichiometry:c276 : 1
stoichiometry:c193 : 1

m5*m104*0.1

nodelay

--

true

0

false

PMID: 18631453 TLR4 in the plasma membrane engages with Mal and subsequently MyD88, for NF-kappaB activation via TRAF6. PMID: 18631453 It might involve activation of PI3 kinase, which via Akt has been shown to block NF-kappaB activation by TLR4.

Go back
451.0, 1155.0
25.0, 25.0

p66

p66

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e30 e97

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c195 : 1
stoichiometry:c198 : 1
stoichiometry:c199 : 1

m32*m101*0.1

nodelay

--

true

0

false

PMID: 18631453 Various stimuli act via Nalp3 to activate caspase-1, which processes the pro-IL-1beta protein into mature IL-1beta. These stimuli include ATP, MDP, uric acid, and asbestos.

Go back
447.0, 1279.0
25.0, 25.0

p67

p67

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e31 e97

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c200 : 1
stoichiometry:c201 : 1

m33*m101*0.1

nodelay

--

true

0

false

PMID: 18631453 Various stimuli act via Nalp3 to activate caspase-1, which processes the pro-IL-1beta protein into mature IL-1beta. These stimuli include ATP, MDP, uric acid, and asbestos.

Go back
447.0, 1326.0
27.0, 27.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 e97

MO000016828

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c197 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m36*m101*0.1

nodelay

--

true

0

false

PMID: 18631453 Various stimuli act via Nalp3 to activate caspase-1, which processes the pro-IL-1beta protein into mature IL-1beta. These stimuli include ATP, MDP, uric acid, and asbestos.

Go back
454.0, 1485.0
25.0, 25.0

p69

p69

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytosol

--

MO000021432 e34

MO000008272

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c207 : 1
stoichiometry:c205 : 1

m5783*m36*0.1

nodelay

--

true

0

false

PMID: 18631453 It also appears to involve reactive oxygen species (ROS) generated by the NADPH oxidase, although how the potassium efflux or ROS generation leads to Nalp3 activation is not known. PMID: 18631453 Uric acid and asbestos have been shown to activate NADPH-oxidase-generating reactive oxygen species (ROS), which are also required for Nalp3 activation, although again a mechanism is missing.

Go back
206.0, 458.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 e80

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c21 : 1
stoichiometry:c132 : 1
stoichiometry:c20 : 1

m18*m84*0.1

nodelay

--

true

0

false

PMID: 18631453 MyD88 adaptor-like (Mal, also called TIRAP) is recruited by TLR2 and TLR4, and so far its main function appears to be to subsequently stabilize MyD88 in the complex, acting as a bridge.

Go back
754.0, 1748.0
23.0, 23.0

p70

p70

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleolus

--

e101

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c208 : 1
stoichiometry:c209 : 1

m105*0.1

nodelay

--

true

0

false

PMID: 18631453 TAM receptors in a complex with IFNAR1 induce SOCS1, which inhibits TLR4 by targeting Mal, and SOCS3, which inhibits TRAF3 and TRAF6.

Go back
1374.0, 957.0
25.0, 25.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000085 e68

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c216 : 1
stoichiometry:c211 : 1

m106*m72*0.1

nodelay

--

true

0

false

PMID: 18631453, 9151903 Notably, the tyrosine kinases Src, Hck, and Lyn have been shown to be activated by TLR4, although their exact role is uncertain because a hck, fyn, lyn triple-deficient mouse was normal for TLR4 signaling.

Go back
1375.0, 1030.0
23.0, 23.0

p72

p72

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000006538 e68

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c212 : 1
stoichiometry:c217 : 1
stoichiometry:c213 : 1

m751*m72*0.1

nodelay

--

true

0

false

PMID: 18631453, 9151903 Notably, the tyrosine kinases Src, Hck, and Lyn have been shown to be activated by TLR4, although their exact role is uncertain because a hck, fyn, lyn triple-deficient mouse was normal for TLR4 signaling.

Go back
1372.0, 1099.0
27.0, 27.0

p73

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Extracellular

--

MO000000144 e68

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c214 : 1
stoichiometry:c218 : 1
stoichiometry:c215 : 1

m128*m72*0.1

nodelay

--

true

0

false

PMID: 18631453, 9151903 Notably, the tyrosine kinases Src, Hck, and Lyn have been shown to be activated by TLR4, although their exact role is uncertain because a hck, fyn, lyn triple-deficient mouse was normal for TLR4 signaling.

Go back
1178.0, 1548.0
25.0, 25.0

p74

p74

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e24 MO000001935

e105

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c219 : 1
stoichiometry:c220 : 1
stoichiometry:c221 : 1

m26*m367*0.1

nodelay

--

true

0

false

PMID: 18631453, 15849198, 17932028, 18276597 Btk is recruited to both TLR4 and TLR9 and has been shown to be involved in the pathway leading to enhanced phosphorylation of the p65 subunit of NF-kappaB on serine 536, which is required for p65 to promote gene expression.

Go back
1397.0, 1595.0
27.0, 27.0

p75

p75

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000001935 e12

e106

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c223 : 1
stoichiometry:c224 : 1
stoichiometry:c222 : 1

m367*m13*0.1

nodelay

--

true

0

false

PMID: 18631453, 15849198, 17932028, 18276597 Btk is recruited to both TLR4 and TLR9 and has been shown to be involved in the pathway leading to enhanced phosphorylation of the p65 subunit of NF-kappaB on serine 536, which is required for p65 to promote gene expression.

Go back
1119.0, 1627.0
23.0, 23.0

p76

p76

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e105 MO000016632

MO000033294

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c225 : 1
stoichiometry:c227 : 1
stoichiometry:c228 : 1

m110*m1617*0.1

nodelay

--

true

0

false

PMID: 18631453, 15849198, 17932028, 18276597 Btk is recruited to both TLR4 and TLR9 and has been shown to be involved in the pathway leading to enhanced phosphorylation of the p65 subunit of NF-kappaB on serine 536, which is required for p65 to promote gene expression.

Go back
1116.0, 1666.0
25.0, 25.0

p77

p77

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e106 MO000016632

MO000033294

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c226 : 1
stoichiometry:c229 : 1
stoichiometry:c230 : 1

m111*m1617*0.1

nodelay

--

true

0

false

PMID: 18631453, 15849198, 17932028, 18276597 Btk is recruited to both TLR4 and TLR9 and has been shown to be involved in the pathway leading to enhanced phosphorylation of the p65 subunit of NF-kappaB on serine 536, which is required for p65 to promote gene expression.

Go back
1397.0, 1655.0
27.0, 27.0

p78

p78

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e105

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c231 : 1

m110*0.1

nodelay

--

true

0

false

PMID: 18631453, 18276597 In B cells, Btk is required for TLR9-induced proliferation and IL-10 production.

Go back
899.0, 1735.0
27.0, 27.0

p79

p79

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e105 G011345

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c233 : 1
stoichiometry:c234 : 1
stoichiometry:c232 : 1

m110*m94230*0.1

nodelay

--

true

0

false

PMID: 18631453, 18276597 In B cells, Btk is required for TLR9-induced proliferation and IL-10 production.

Go back
1401.0, 1389.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000022224 MO000019398

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m119368*m3965*0.1

nodelay

--

true

0

false

PMID: 18631453 TLR3, which senses double-stranded RNA.

Go back
979.0, 1687.0
27.0, 27.0

p80

p80

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G011345 e106

MO000017247

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c236 : 1
stoichiometry:c237 : 1
stoichiometry:c235 : 1

m94230*m111*0.1

nodelay

--

true

0

false

PMID: 18631453, 17082638 Btk is also required for IL-10 induction by TLR4 in macrophages.

Go back
499.0, 731.0
25.0, 25.0

p81

p81

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000000022 MO000001935

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c240 : 1
stoichiometry:c239 : 1

m20*m367*0.1

nodelay

--

true

0

false

PMID: 18631453 There is a role in TNF production, however, which was shown to be due to Btk's being required for p38 activation, which then stabilizes TNF but not IL-6 mRNA.

Go back
1418.0, 658.0
27.0, 27.0

p82

p82

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000001935 e68

e108

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c243 : 1
stoichiometry:c242 : 1
stoichiometry:c241 : 1

m367*m72*0.1

nodelay

--

true

0

false

PMID: 18631453, 16439361, 18070880 One substrate is Mal, which undergoes phosphorylation by Btk on Tyr-86 and Tyr-106.

Go back
1239.0, 739.0
25.0, 25.0

p83

p83

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000017004 e108

e107

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c244 : 1
stoichiometry:c245 : 1
stoichiometry:c246 : 1

m1906*m113*0.1

nodelay

--

true

0

false

PMID: 18631453, 16415872 This event is required for Mal to signal NF-kappaB activation but, in addition, is involved in the ultimate degradation of Mal via the recruitment of suppressor of cytokine signaling 1 (SOCS1).

Go back
1254.0, 786.0
27.0, 27.0

p84

p84

cso30:i:ME_UnknownDegradation

cso30:i:CC_Cytosol

--

e107

MO000019479 e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c247 : 1
stoichiometry:c248 : 1
stoichiometry:c250 : 1

m112*0.1

nodelay

--

true

0

false

PMID: 18631453, 16415872 This event is required for Mal to signal NF-kappaB activation but, in addition, is involved in the ultimate degradation of Mal via the recruitment of suppressor of cytokine signaling 1 (SOCS1).

Go back
362.0, 742.0
27.0, 27.0

p85

p85

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e110 MO000008301

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c253 : 1
stoichiometry:c252 : 1

m115*m1066*0.1

nodelay

--

true

0

false

PMID: 18631453 The tyrosine kinase Syk plays a key role in DAP12 activation, phosphorylating tyrosine residues, and allowing for the recruitment of SH2-domain-containing proteins such as the p85-p110 dimer of PI3 kinase and phospholipase Cgamma.

Go back
380.0, 812.0
27.0, 27.0

p86

p86

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e111 MO000033499

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c254 : 1
stoichiometry:c255 : 1
stoichiometry:c256 : 1

m116*m12175*0.1

nodelay

--

true

0

false

PMID: 18631453 The tyrosine kinase Syk plays a key role in DAP12 activation, phosphorylating tyrosine residues, and allowing for the recruitment of SH2-domain-containing proteins such as the p85-p110 dimer of PI3 kinase and phospholipase Cgamma.

Go back
381.0, 888.0
25.0, 25.0

p87

p87

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e111 MO000000102

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c257 : 1
stoichiometry:c259 : 1
stoichiometry:c258 : 1

m116*m119*0.1

nodelay

--

true

0

false

PMID: 18631453 The tyrosine kinase Syk plays a key role in DAP12 activation, phosphorylating tyrosine residues, and allowing for the recruitment of SH2-domain-containing proteins such as the p85-p110 dimer of PI3 kinase and phospholipase Cgamma.

Go back
519.0, 1793.0
27.0, 27.0

p88

p88

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e114 e110

MO000019387

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c262 : 1
stoichiometry:c261 : 1

m120*m115*0.1

nodelay

--

true

0

false

PMID: 1831453 At first, this seemed counterintuitive, because ITAM-containing proteins that couple to receptors had been shown to activate signaling pathways leading to inflammatory cytokine production, such as DAP12, which couples to the coreceptor TREM-1.

Go back
1366.0, 306.0
23.0, 23.0

p89

p89

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000019394 e115

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m3961*m121*0.1

nodelay

--

true

0

false

PMID: 18631453 The effect here appears to be proximity dependent¡½the antibody binds to TLR4 and the Fc portion binds to CD32A, bringing it into close proximity to TLR4.

Go back
1403.0, 1491.0
25.0, 25.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042012 e20

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m19828*m22*0.1

nodelay

--

true

0

false

PMID: 18631453 The best characterized are TLR2, which in combination with TLR1 or TLR6 can recognize acylated lipopeptides; TLR3, which senses double-stranded RNA; TLR4, which senses LPS; and TLR9, which senses hypomethylated CpG motifs. PMID: 18631453, 17572678 In the case of TLR9, it has been shown that a pre-exising dimer occurs, which presumably ¡Ètightens¡É upon ligand binding to create a new conformation.

Go back
1274.0, 226.0
27.0, 27.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e116 e117

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c266 : 1
stoichiometry:c267 : 1
stoichiometry:c268 : 1

m122*m123*0.1

nodelay

--

true

0

false

PMID: 18631453 The effect here appears to be proximity dependent¡½the antibody binds to TLR4 and the Fc portion binds to CD32A, bringing it into close proximity to TLR4.

Go back
1110.0, 962.0
23.0, 23.0

p91

p91

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000030 e118

e119

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c271 : 1
stoichiometry:c270 : 1

m125*m124*0.1

nodelay

--

true

0

false

PMID: 18631453 It might involve activation of PI3 kinase, which via Akt has been shown to block NF-kappaB activation by TLR4.

Go back
985.0, 965.0
25.0, 25.0

p92

p92

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000048 e119

e120

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c272 : 1
stoichiometry:c274 : 1
stoichiometry:c273 : 1

m127*m126*0.1

nodelay

--

true

0

false

PMID: 18631453 It might involve activation of PI3 kinase, which via Akt has been shown to block NF-kappaB activation by TLR4.

Go back
552.0, 872.0
23.0, 23.0

p93

p93

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000102 e118

e121

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c277 : 1
stoichiometry:c279 : 1
stoichiometry:c278 : 1

m119*m124*0.1

nodelay

--

true

0

false

PMID: 18631453 Alternatively, because CD32A can activate phospholipase C-gamma, a depletion in PIP2 by this enzyme might lead to Mal's dissociation from the plasma membrane.

Go back
1207.0, 127.0
25.0, 25.0

p94

p94

cso30:i:ME_UnknownProduction

cso30:i:CC_Cytoplasm

--

MO000000102

MO000000331

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c281 : 1
stoichiometry:c280 : 1

1.0*0.1

nodelay

--

true

0

false

PMID: 18631453 Alternatively, because CD32A can activate phospholipase C-gamma, a depletion in PIP2 by this enzyme might lead to Mal's dissociation from the plasma membrane.

Go back
1225.0, 464.0
25.0, 25.0

p95

p95

cso30:i:ME_Dissociation

cso30:i:CC_Cytoplasm

--

e80 MO000000102

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c284 : 1
stoichiometry:c283 : 1

m84*m119*0.1

nodelay

--

true

0

false

PMID: 18631453 Alternatively, because CD32A can activate phospholipase C-gamma, a depletion in PIP2 by this enzyme might lead to Mal's dissociation from the plasma membrane.

Go back
1008.0, 1987.0
27.0, 27.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e122 MO000021702

e123

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c285 : 1
stoichiometry:c286 : 1
stoichiometry:c287 : 1

m131*m6039*0.1

nodelay

--

true

0

false

PMID: 18631453 Gas6 binds all three, although with different affinities.

Go back
965.0, 1992.0
25.0, 25.0

p97

p97

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e124 e123

e125

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c288 : 1
stoichiometry:c290 : 1
stoichiometry:c289 : 1

m133*m132*0.1

nodelay

--

true

0

false

PMID: 18631453 The ligands for the TAM receptors Gas6 and Protein S activate a signaling pathway via the R1 subunit of the type I interferon receptor, which has been shown to occur in a complex with Axl.

Go back
961.0, 1812.0
25.0, 25.0

p98

p98

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000013119 e125

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c291 : 1
stoichiometry:c293 : 1
stoichiometry:c292 : 1

m1357*m134*0.1

nodelay

--

true

0

false

PMID: 18631453 This leads to activation of STAT1 and, in turn, induction of SOCS1 and SOCS3, which act to block TLR signaling.

Go back
793.0, 1735.0
25.0, 25.0

p99

p99

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e126

G010539

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c294 : 1

m135*0.1

nodelay

--

true

0

false

PMID: 18631453 This leads to activation of STAT1 and, in turn, induction of SOCS1 and SOCS3, which act to block TLR signaling.

Go back
557.0, 244.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1172.0, 518.0

c10

c10

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
896.0, 431.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.55182132224684, 223.5836422642039

c101

c101

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.4894110299791, 482.0

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
232.0, 523.0

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1139.0, 570.0

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1044.0, 1065.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
924.9565555251719, 1138.3403601260163

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 1056.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1066.3342580445078, 1114.0

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1060.0, 1150.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1330.0, 455.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
942.0, 1166.2635457547435

c110

c110

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 1270.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1031.9978624628054, 1428.0

c112

c112

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1016.0, 1444.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1213.0, 1202.0

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1226.065902322058, 1216.0

c115

c115

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1135.3941549121707, 1165.0

c116

c116

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.1554175279994, 1266.0

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0, 1300.0

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1133.0, 1302.0

c119

c119

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1347.0, 566.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.0, 1309.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
978.9249690339478, 1559.0930991770963

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1130.0, 1202.0

c122

c122

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
938.0, 1202.0

c123

c123

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1057.0, 1408.9913606886246

c124

c124

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.3601918319166, 1316.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.0, 1346.0

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1024.0817523504895, 1401.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
960.0, 1491.0

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
872.0, 1122.0

c129

c129

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
250.65640235470275, 311.4376015698018

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1341.0, 532.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1162.0, 429.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
150.997924775123, 199.6855843721264

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 1246.0

c133

c133

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
843.0, 1195.0

c134

c134

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1184.9955592558333, 414.2665186418611

c135

c135

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1162.0, 486.0

c136

c136

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
862.0, 1173.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
911.0, 1174.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
919.0, 1122.0

c139

c139

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.0, 299.0

c14

c14

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
999.0, 1063.535742906118

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.0, 1016.0

c141

c141

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.0, 1001.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
466.0, 1050.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
721.0, 258.0

c144

c144

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
742.0085798749974, 351.8574354350761

c145

c145

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
722.0, 354.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.0, 436.7197343215694

c147

c147

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
738.0, 456.0

c148

c148

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
235.96127590105803, 454.0

c149

c149

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
246.9932582089723, 392.0

c15

c15

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
730.0, 1397.9973027645894

c150

c150

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
697.885143449429, 1313.9932582089723

c151

c151

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.0, 1293.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
574.0, 1293.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
570.0, 1308.599564133703

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
734.9735529449453, 1100.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
219.5433724859686, 1235.0

c156

c156

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.0, 1398.0

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.0, 1399.0547932353022

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
216.81509280259235, 1235.0

c159

c159

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
240.0, 419.0

c16

c16

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
166.0, 1448.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
214.0, 1449.0551711017729

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.0, 1235.0

c162

c162

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
435.0, 1554.0

c163

c163

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.0, 1494.0

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
224.0, 1494.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
320.37799490386163, 1514.6957569117883

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
326.3148177390106, 1508.9115249081194

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
388.0, 1543.2351924128152

c168

c168

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 1559.56916668859

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
203.0, 318.09551454207565

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
453.2679814327163, 1556.9711576880163

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.4605447861927, 1175.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
507.0, 1422.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.273859510597, 1510.0

c173

c173

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.0, 1217.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.0, 1224.2753164671878

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
126.82310220547822, 181.66625796208905

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
482.02653554568815, 1183.0

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.0, 1260.0

c178

c178

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
385.0, 1266.8749375785312

c179

c179

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
199.0, 362.0

c18

c18

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 1248.0701727388662

c180

c180

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
896.0, 429.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1341.0, 870.0

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1343.6387405546145, 880.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
819.0, 1040.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.0, 1084.0

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
880.5841831432634, 935.0

c186

c186

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
674.9303012300632, 1100.0

c187

c187

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
683.0, 1480.0

c188

c188

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1038.0, 608.0

c189

c189

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1120.0, 414.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1200.789539285751, 621.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1236.9940893970504, 608.3074649768097

c191

c191

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
820.0, 1025.0

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
790.8415826524322, 1034.0

c193

c193

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
882.3994013885963, 710.0

c194

c194

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
391.0, 1168.266518641861

c195

c195

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
390.0, 1291.0

c196

c196

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
389.0, 1340.2756982067183

c197

c197

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.0, 1168.0

c198

c198

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
470.0, 1180.0

c199

c199

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
573.0, 263.4943375652156

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
231.0, 471.0

c20

c20

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
474.90687006233946, 1185.0

c200

c200

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
472.0, 1298.0

c201

c201

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
472.8724910813381, 1185.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 1340.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
476.15135438863337, 1422.0

c204

c204

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
470.0, 1510.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 1311.0

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
384.0, 1362.0

c207

c207

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
767.7889283700024, 1778.9610044609337

c208

c208

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
766.0, 1728.0

c209

c209

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
237.53985946504778, 431.0

c21

c21

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1243.0, 969.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1250.8108968747372, 973.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1244.0, 1041.0

c212

c212

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1251.8232921975357, 1045.0

c213

c213

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1246.0, 1112.0

c214

c214

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.8094964814716, 1116.0

c215

c215

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1327.0, 635.0

c216

c216

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1326.0, 635.0

c217

c217

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1326.0, 635.0

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1143.0, 1533.0

c219

c219

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1413.0, 1348.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.0, 1561.0

c220

c220

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1111.8405438169862, 1544.589299422362

c221

c221

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1343.0, 1609.0

c222

c222

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1257.0, 1565.0

c223

c223

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1336.0, 441.0

c224

c224

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1098.0, 1563.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1148.5019900857897, 1615.0

c226

c226

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1076.0, 1638.0

c227

c227

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1080.0289960765804, 1645.0

c228

c228

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1076.0, 1648.0

c229

c229

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1227.0, 1393.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1081.0, 1679.0

c230

c230

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1104.0, 1546.0

c231

c231

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
926.0, 1749.0

c232

c232

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
930.1283349481207, 1559.0

c233

c233

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
866.0, 1683.0

c234

c234

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
993.0, 1714.0

c235

c235

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.0, 1672.0

c236

c236

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1013.7047889074764, 1614.0

c237

c237

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
530.1861423239712, 693.0

c238

c238

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
524.0, 744.0

c239

c239

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1235.936087712431, 1404.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
528.3312722762571, 761.9646907645252

c240

c240

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1343.9156885130728, 674.0

c241

c241

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1339.0, 621.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1257.0, 673.7964840527636

c243

c243

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1252.0, 701.0

c244

c244

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1269.7999954687552, 703.0

c245

c245

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1264.0, 753.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1287.0545840621533, 769.0

c247

c247

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1253.352465419694, 813.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
747.9337864095419, 697.0

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1169.0, 1504.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1281.0, 801.0

c250

c250

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
296.0, 686.0

c251

c251

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.0, 756.0

c252

c252

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
396.9930645847388, 753.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
308.0, 767.0

c254

c254

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.0, 826.0

c255

c255

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
323.0, 826.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
308.0, 779.0

c257

c257

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
326.0, 901.0

c258

c258

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
413.90458495826465, 887.0

c259

c259

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1416.0, 1524.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
543.6048896162828, 1688.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
513.8596008605664, 1782.3548626638176

c261

c261

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
72.29518282337864, 675.5524011357957

c262

c262

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1330.0, 335.05458406215325

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1397.0, 318.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1349.9930645847387, 319.0

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1297.343244865857, 260.2679236214286

c266

c266

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1287.0, 260.99723135482276

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1263.3332376839458, 253.0

c268

c268

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1081.0, 936.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1150.9808970439155, 1505.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1089.0, 974.0

c270

c270

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.5445745115258, 342.0

c271

c271

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
952.0, 947.0

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.9947159835715, 978.0

c273

c273

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1017.9904988089992, 975.0

c274

c274

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
744.8762840268325, 984.0

c275

c275

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
877.9896372747346, 992.0

c276

c276

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
513.0, 884.2050608063404

c277

c277

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.7751199108245, 892.0

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
554.3104088140308, 165.00415319954624

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
203.0, 980.9955592558332

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1220.0, 152.0

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
57.537759455240234, 140.00474829423123

c281

c281

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1257.2080133580728, 486.4705249501832

c282

c282

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1186.9924492668404, 475.3474977942105

c283

c283

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
45.683892147026654, 112.97084546103895

c284

c284

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1036.629976047529, 1956.0

c285

c285

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1043.0, 2001.0

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1022.0, 1965.0

c287

c287

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
978.0, 1965.0

c288

c288

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.3517178529796, 1957.9463531699773

c289

c289

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
224.86897289521832, 972.1008793404288

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.2719439311038, 1954.0

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
994.0, 1825.0

c291

c291

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 1825.0

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
927.0, 1843.8021211735029

c293

c293

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
785.4585460028801, 1725.848442145943

c294

c294

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
824.038974994921, 1764.2469782742755

c295

c295

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
828.4063762906391, 1706.238549617608

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.0005950167381, 1745.9278596631318

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1060.0, 380.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1029.0, 319.0

c299

c299

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
608.0, 256.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
218.0, 960.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1048.0, 317.7839864320407

c300

c300

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1125.0, 235.24695047554425

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1166.0, 216.04139833194495

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1165.0, 229.0

c303

c303

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1154.0, 229.0

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
598.0, 1630.0

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
660.0, 1649.0

c306

c306

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
24.16839007327735, 91.51903086968616

c307

c307

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
36.01712321359247, 103.53477362808007

c308

c308

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
656.0078295040328, 108.34867530888414

c309

c309

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
222.99632943316306, 1054.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
657.2607309808976, 1726.0

c310

c310

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.1554175279994, 1839.0

c311

c311

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 1816.0

c312

c312

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0925202920774, 1726.0

c313

c313

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
529.0, 1816.4025068970707

c314

c314

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
587.0345155349518, 331.7690319664448

c315

c315

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
728.0403981326061, 301.0

c316

c316

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
876.7226911347584, 311.0

c317

c317

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
804.6169894699772, 549.4961595116512

c318

c318

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.0097021343819, 293.0

c319

c319

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
215.0, 1064.0

c32

c32

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.0, 1360.0

c320

c320

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
874.773092393688, 1368.0

c321

c321

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
868.0, 1370.0

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
876.0, 1400.0

c323

c323

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
935.9997805302936, 1358.0

c324

c324

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
928.7618204050059, 1417.428457546758

c325

c325

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
911.0, 1352.8850452295649

c326

c326

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
907.0, 1483.0

c327

c327

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
708.0, 1852.0

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
702.4924053533731, 1778.0

c329

c329

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
202.0, 1077.0

c33

c33

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
695.8794945921586, 95.81312811694352

c330

c330

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
724.0, 1652.0

c331

c331

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
734.7507930175838, 1416.0

c332

c332

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
676.5388653451763, 1416.0

c333

c333

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
611.0111288665283, 1611.0

c334

c334

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
738.8284271247462, 1483.0

c335

c335

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
674.4871887411525, 1476.0

c336

c336

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
428.91004431870346, 360.19632724458944

c337

c337

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
379.0, 325.0

c338

c338

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
409.0, 332.0

c339

c339

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
202.0, 1129.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1074.0, 532.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1228.0, 1430.0

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1211.989918334537, 1453.0

c342

c342

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
937.9675012930073, 424.3281261544708

c343

c343

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
956.0, 229.0

c344

c344

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
973.0, 243.95393826955726

c345

c345

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1038.0, 613.0

c346

c346

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1061.0, 644.6132233653639

c347

c347

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1108.0, 652.0

c348

c348

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
740.9709676259196, 547.0

c349

c349

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.66404373436666, 1176.2939994851165

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.0, 526.0

c350

c350

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
602.0, 525.0

c351

c351

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.9223518172148, 567.0

c352

c352

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
592.0, 577.0

c353

c353

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
538.7907296779343, 580.0

c354

c354

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
475.9958409147176, 591.0

c355

c355

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
418.8629774954746, 594.0

c356

c356

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
411.0, 617.0

c357

c357

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
475.99723135482276, 653.0

c358

c358

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
415.9965420357148, 655.0

c359

c359

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
215.0, 1170.0

c36

c36

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
599.0, 692.0

c360

c360

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.9909451017955, 741.0

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
677.0, 740.0

c362

c362

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
657.3413444076746, 292.0

c363

c363

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
751.7037121577134, 526.1570394041597

c364

c364

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1106.0, 752.0

c365

c365

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1147.0, 752.0

c366

c366

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1211.0, 871.0856580228888

c367

c367

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1179.0, 852.0

c368

c368

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
230.36407692653424, 1227.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.0, 1536.0

c371

c371

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
589.271030765326, 1465.0

c372

c372

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
539.0028719586807, 701.288244344552

c373

c373

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
533.0, 682.3897804297072

c374

c374

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
523.1904792409355, 704.9109265687972

c375

c375

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
605.0, 1347.7844645405528

c376

c376

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
911.0, 1644.2719439311038

c377

c377

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
919.1554175279994, 1621.5777087639997

c378

c378

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
958.9195205871675, 1612.0

c379

c379

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
164.0, 1291.0

c38

c38

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
820.0, 1400.0

c380

c380

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
816.4057970281387, 1417.897233121606

c381

c381

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.5298221281347, 1379.5894663844042

c382

c382

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
807.6904268220918, 1415.6252527027991

c383

c383

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
758.3966562177775, 1372.0

c384

c384

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.4551156035938, 1537.0154841020963

c385

c385

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1105.0, 793.0

c386

c386

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1158.0, 796.0

c387

c387

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1171.4654160868197, 765.0

c388

c388

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1202.2987830845307, 807.0

c389

c389

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
223.0, 1291.0596998301683

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1123.0, 813.7329635378675

c390

c390

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1121.0, 770.9510698773889

c391

c391

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
793.0, 428.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
225.4698886744255, 1231.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
172.0, 1344.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
219.0, 1343.0575524674778

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.4334091317306, 1679.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
177.0, 1722.0

c44

c44

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 1722.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
377.0, 1935.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.0, 1942.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
382.0, 1980.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
660.0, 256.0

c49

c49

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
772.0, 359.0

c5

c5

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
675.0, 348.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
938.8383001217738, 419.1518250739341

c51

c51

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
788.0, 337.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
935.0683443965039, 426.18965952847384

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
842.8623479330104, 336.4436087949382

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
837.0, 242.44044669882695

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
888.0, 236.0

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
905.0, 235.32765345276295

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1021.0, 238.0

c58

c58

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.9869886751273, 319.0

c59

c59

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
618.0, 263.09267876932364

c6

c6

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
792.8664792881382, 355.34959678547557

c60

c60

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
917.0, 512.0

c61

c61

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
954.0, 559.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
975.997733389953, 607.1904222235703

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
914.9969153652218, 607.0

c64

c64

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
975.0, 674.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.9675012930073, 688.0

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
976.0, 728.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.0, 634.0

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 674.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1332.0, 397.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.0, 674.0

c70

c70

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
891.0, 630.0

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1013.0, 741.0

c72

c72

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.427813527082, 707.0

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.6586216862936, 734.3120367354849

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1031.2018798841384, 743.0533836092978

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.5894663844041, 802.0

c76

c76

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
940.9889426346601, 810.4204706649821

c77

c77

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.0, 836.0

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
936.0, 874.0

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1402.0, 390.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
846.0, 874.0

c80

c80

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
775.0, 926.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
787.3775550546283, 946.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 897.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
830.613703039687, 752.5009923464537

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
852.0, 810.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 740.0

c86

c86

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
768.0, 692.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
770.0, 827.330647868242

c88

c88

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
782.9439061935595, 811.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1344.0, 438.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
748.992766725465, 1025.0

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
737.0, 1041.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
739.8466608896548, 983.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
411.0, 604.0

c93

c93

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 625.0

c94

c94

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
636.0, 633.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.0, 818.0

c96

c96

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
631.0, 818.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
669.4376015698018, 832.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1146.9994398543615, 566.0

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back