1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18641647.csml convertedTime:2009.07.01.11:20

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Plasmacytoid dendritic cells: sensing nucleic acids in viral infection andautoimmune diseases.
Authors Gilliet M, Cao W, Liu YJ.
Affiliation Department of Immunology and Center of Cancer Immunology Research, TheUniversity of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Abstract Plasmacytoid dendritic cells (pDCs) are important mediators of antiviralimmunity through their ability to produce large amounts of type I interferons(IFNs) on viral infection. This function of pDCs is linked to their expressionof Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids withinthe early endosomes. Exclusion of self nucleic acids from TLR-containing earlyendosomes normally prevents pDC responses to them. However, in some autoimmunediseases, self nucleic acids can be modified by host factors and gain entranceto pDC endosomes, where they activate TLR signalling. Several pDC receptorsnegatively regulate type I IFN responses by pDCs during viral infection and fornormal homeostasis.
PMID 18641647
Model Abstract

Entity

G010228:IFN-beta G010240:MHC G010262:IL-6 G010329:TNF-alpha G010691:CD40 G010859:CD86 G012224:CD80 G012384:IFNW1 G016992:IFN-alpha1 MO000000030:PI3K MO000000077:MAPKs MO000000210:IKK-alpha MO000000212:TRAF6 MO000000213:IRAK MO000000254:p50:RelA-p65:IkappaB-alpha{p} MO000000289:TNF-alpha MO000000311:LL37 MO000001935:Btk MO000007185:IRF-8 MO000007384:IL-6 MO000007694:IRF-3 MO000007697:IRF-4 MO000007700:IRF-5 MO000007702:IRF-7 MO000008179:PKR MO000016573:MyD88 MO000016574:TAK1 MO000016632:p50:RelA-p65{activated} MO000016658:IFN Type I MO000016659:IFNalpha1 MO000016660:IFNbeta MO000016882:LPS MO000016963:TRAF3 MO000019331:TBK1 MO000019398:TLR3 MO000022224:dsRNA MO000038724:p50:RelA-p65:IkappaB-alpha MO000039077:IRAK-4 MO000041125:TRIF MO000041132:TRAM MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042007:TLR8 MO000042012:TLR9 MO000042032:PGN MO000042126:TLR7 MO000061281:RNASEL{activated} MO000061307:OPN MO000061425:DAI MO000068831:MAL MO000094908:IPS1 MO000103999:MDA-5 e1: e10: e100:p50:RelA-p65{activated} e101:dsRNA: DAI e102:TBK1{activated} e103:IFN Type I e104:PKR{activated} e105:5'-triphosphate e106:self RNA e107:RNASEL e108:2', 5'--linked oligoadenylate e109:small RNA cleavage products e11: e110:IFNAR e111:IFNbeta e112:IFN beta: IFNAR e113:MyD88: IRF-5 e114:MyD88: IRF-4 e115:UNC93B e116:TLR3: UNC93B: gp96 e117:TLR7: UNC93B: gp96 e118:TLR9: UNC93B: gp96 e119:gp96 e12:TLR4 e120:A type CpG ODN: TLR9 e121:Type B CpG ODN: TLR9 e122:A type CpG ODN: TLR9: MyD88 e123:IRAK-4: TRAF6 e124:IRAK-4: TRAF6{activated} e125:IRAK-1: TRAF3: OPN: IRF-7 e126:IRAK-1: TRAF3: OPN: IRF-7 e127:IFNL e128:IFNW1 e129:IRAK4:TRAF6: BTK e13:TLR5 e130:IRAK4:TRAF6: BTK e131:Type B CpG ODN: TLR9: MyD88 e132:self DNA e133:LL37: self DNA e134:HMGB1 e135:LL37: self DNA: HMGB1 e136:RAGE e137:LL37: self DNA: HMGB1: RAGE e138:LL37: self DNA: HMGB1: TLR9 e139:LL37: self DNA: HMGB1: TLR9: MyD88 e14:LPS: TLR4 e140:LL37: self DNA: HMGB1 e141:DNA-specific IgG antibody e142:LL37: self DNA: HMGB1: DNA-specific IgG antibody e143:FCgammaRIIA e144:LL37: self DNA: HMGB1: DNA-specific IgG antibody: FCgammaRIIA e145:LL37: self DNA: HMGB1: DNA-specific IgG antibody: TLR9 e146:snRNA e147:snRNA: TLR7 e148:auto-antibody e149:BDCA2ligand: BDCA2 e15:flagellin: TLR5 e150:ILT7 ligand: ILT7 e151:BDCA2ligand: BDCA2: IgE: FCepsilonRIgamma e152:IgE: FCepsilonRIgamma e153:ILT7 ligand: ILT7: IgE: FCepsilonRIgamma e154:ligand: DAP12 e155:ligand: NKp44 e156:ligand: Siglec-H e157:ligand: NKp44: ligand: DAP12 e158:ligand: Siglec-H: ligand: DAP12 e159:PTKs e16:flagellin e160:PTKs{activated} e161:Syk{activated} e162:Syk e163:BLNK: BCAP e164:BLNK: BCAP{activated} e165:FcgammaRIIA e166:PDC-TREM: plexin A1 e167:semaphorin 6D e168:semaphorin 6D: PDC-TREM: plexin A1 e169:PI3K{activated} e17:Lp e170:ERK1 e171:ERK2 e172:ERK1{activated} e173:ERK2{activated} e174:PDC-TREM e175:plexin A1 e176:nucleortide: P2Y e177:ADP e178:P2Y e179:ligand: BCR e18:TLR1: TLR2 e180:ligand: BCR{activated} e181:self RNA e182:self RNA: TLR7 e183:IL-12 e184:IL-12 e185:IFN-gamma e186:IFN-gamma e187:antibody e188:antibody e19:Lp: TLR1: TLR2 e2: e20:CpG ODN e21:TLR6: TLR2 e22:PGN: TLR6: TLR2 e23:ssRNA e24:ssRNA: TLR7 e25:ssRNA: TLR8 e26:CpG DNA: TLR9 e27:imiquimod e28:imidazoquinoline: TLR7 e29:imidazoquinoline: TLR8 e3: e30:R-848 e31:R-848: TLR8 e32:R-848: TLR7 e33:guanosine analogues e34:guanosine analogues: TLR7 e35:guanosine analogues: TLR8 e36:CpG ss-DNA e37:CpG ODN: TLR9 e38:LPS: TLR4: MAL e39:LPS: TLR4: MAL: MyD88 e4: e40:LPS: TLR4: TRAM e41:LPS: TLR4: TRAM: TRIF e42:Lp: TLR1: TLR2: MAL e43:Lp: TLR1: TLR2: MAL: MyD88 e44:poly I:C: TLR3 e45:Poly I:C: TLR3 e46:ssRNA: TLR7: MyD88 e47:ssRNA: TLR8: MyD88 e48:CpG DNA: TLR9: MyD88 e49:ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: BTK e5: e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6: e60: e61: e62: e63:ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: BTK e64:CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: BTK e65:MAPKs{activated} e66:IRAK-1: IRAK4:TRAF6: BTK: IRF-7 e67:IRAK-1: IRAK4:TRAF6: BTK: IRF-7{ub} e68:IRAK1: IRF-7{ub}: TRAF3: TABK1: IKK-alpha: OPN: PI3K e69:IRAK1: IRF-7{ub} e7: e70:IRAK-1: TRAF6: BTK e71:TAK1{activated} e72:IRAK-1: IRAK4:TRAF6: BTK{activated} e73:IRF-5{activated} e74:IRF-7{ub}{p} e75:IFNL e76:TRAF3: TBK1: IKK-i e77:p50:RelA-p65{activated} e78:TRAF3: TBK1: IKK-i{activated} e79:RIG-1 e8: e80:dsRNA e81:dsRNA: RIG-1 e82:dsRNA: MDA-5 e83:dsRNA: LGP2 e84:LGP2 e85: e86: e87: e88: e89: e9: e90: e91: e92: e93: e94:dsRNA: RIG-1: IPS1 e95:dsRNA: MDA-5: IPS1 e96:dsRNA: LGP2: IPS1 e97:dsRNA: RIG1: IPS1: TRAF3: TBK1: IKK-i e98:FADD: caspase-8 e99:FADD: caspase-8{activated}

Process

p1 p10 p100 p101 p102 p103 p104 p105 p106 p107 p108 p109 p11 p110 p111 p112 p113 p114 p115 p116 p117 p118 p119 p12 p120 p121 p122 p123 p124 p125 p126 p127 p128 p129 p13 p130 p131 p132 p133 p134 p135 p136 p137 p138 p139 p14 p140 p141 p142 p143 p144 p145 p146 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p62 p63 p64 p65 p66 p67 p68 p69 p7 p70 p71 p72 p73 p74 p75 p76 p77 p78 p79 p8 p80 p81 p82 p83 p84 p85 p86 p87 p88 p89 p9 p90 p91 p92 p93 p94 p95 p96 p97 p98 p99
Model Detail
917.0, 1377.0
30.0, 30.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p43 p82

p55 p94

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
925.0, 1273.0
29.0, 29.0

MHC

--

G010240

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p99

--

true true true true

csml-variable:Double

m93228

10

false

infinite

0

unit false false false

--

Go back
1142.0, 1478.0
28.0, 28.0

IL-6

--

G010262

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p50 p86

p109

true true true true

csml-variable:Double

m93248

10

false

infinite

0

unit false false false
TRANSFACG010262

--

Go back
1035.0, 1443.0
34.0, 34.0

TNF-alpha

--

G010329

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p49 p85

p108

true true true true

csml-variable:Double

m93309

10

false

infinite

0

unit false false false
TRANSFACG010329

--

Go back
893.0, 1597.0
29.5, 29.5

CD40

--

G010691

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p89

--

true true true true

csml-variable:Double

m93612

10

false

infinite

0

unit false false false

--

Go back
990.0, 1586.0
28.5, 28.5

CD86

--

G010859

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p52 p87

--

true true true true

csml-variable:Double

m93745

10

false

infinite

0

unit false false false
TRANSFACG010859

--

Go back
1013.0, 1513.0
30.0, 30.0

CD80

--

G012224

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p51 p88

--

true true true true

csml-variable:Double

m95018

10

false

infinite

0

unit false false false
TRANSFACG012224

--

Go back
917.0, 1453.0
30.0, 30.0

IFNW1

--

G012384

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p47 p84

p105

true true true true

csml-variable:Double

m95135

10

false

infinite

0

unit false false false
TRANSFACG012384

--

Go back
913.0, 1341.0
29.0, 29.0

IFN-alpha1

--

G016992

cso30:c:mRNA

cso30:i:CC_CellComponent

--

p38 p81

p78

true true true true

csml-variable:Double

m98717

10

false

infinite

0

unit false false false
TRANSPATHG016992

--

Go back
1062.0, 906.0
27.0, 27.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p34 p135

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1197.0, 927.0
34.0, 34.0

MAPKs

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p57

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1060.0, 940.0
32.0, 32.0

IKK-alpha

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p34

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
893.0, 705.0
26.5, 26.5

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p28 p29

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
881.0, 589.0
25.0, 25.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p103

p27 p28 p29

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
1137.0, 1070.0
36.0, 36.0

p50:RelA-p65:IkappaB-alpha{p}

--

MO000000254

cso30:c:Protein

cso30:i:CC_CellComponent

--

p33 p56 p111

p37

true true true true

csml-variable:Double

m208

10

false

infinite

0

unit false false false
TRANSPATHMO000000254

--

Go back
971.0, 1671.0
34.5, 34.5

TNF-alpha

--

MO000000289

cso30:c:Protein

cso30:i:CC_CellComponent

--

p108

--

true true true true

csml-variable:Double

m230

10

false

infinite

0

unit false false false
InterProIPR003636
TRANSPATHMO000000289

--

Go back
67.0, 1177.0
42.53014689761017, 21.97390923043192

LL37

--

MO000000311

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p95

true true true true

csml-variable:Double

m230108

10

false

infinite

0

unit false false false
TRANSPATHMO000000311

--

Go back
878.0, 550.0
27.5, 27.5

Btk

--

MO000001935

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p28 p29

true true true true

csml-variable:Double

m367

10

false

infinite

0

unit false false false
InterProIPR001452
TRANSPATHMO000001935

--

Go back
726.0, 1522.0
28.0, 28.0

IRF-8

--

MO000007185

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p79

true true true true

csml-variable:Double

m769

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007185

--

Go back
1087.0, 1651.0
26.0, 26.0

IL-6

--

MO000007384

cso30:c:Protein

cso30:i:CC_CellComponent

--

p109

p120

true true true true

csml-variable:Double

m871

10

false

infinite

0

unit false false false
InterProIPR003573
TRANSPATHMO000007384

--

Go back
522.0, 1178.0
30.0, 30.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p66 p70

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
1161.0, 649.0
32.0, 32.0

IRF-4

--

MO000007697

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p90

true true true true

csml-variable:Double

m978

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007697

--

Go back
1196.0, 744.0
31.5, 31.5

IRF-5

--

MO000007700

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p40 p80 p112

true true true true

csml-variable:Double

m979

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
1068.0, 628.0
32.0, 32.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p39

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
913.0, 265.0
29.0, 29.0

PKR

--

MO000008179

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p73

true true true true

csml-variable:Double

m1055

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
997.0, 369.0
30.0, 30.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p16 p20 p24 p25 p26 p80 p90 p100 p110 p113

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
1195.0, 842.0
32.0, 32.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p35 p107

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
1140.5, 1120.0
31.5, 31.5

p50:RelA-p65{activated}

--

MO000016632

cso30:c:Protein

cso30:i:CC_CellComponent

--

p37 p68 p71

p48

true true true true

csml-variable:Double

m1617

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
541.0, 1449.0
30.0, 30.0

IFN Type I

--

MO000016658

cso30:c:Protein

cso30:i:CC_CellComponent

--

p72 p122 p138

p119 p120

true true true true

csml-variable:Double

m1634

10

false

infinite

0

unit false false false
TRANSPATHMO000016658

--

Go back
115.0, 1367.0
26.0, 26.0

IFNalpha1

--

MO000016659

cso30:c:Protein

cso30:i:CC_CellComponent

--

p78

--

true true true true

csml-variable:Double

m1635

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016659

--

Go back
577.0, 1377.0
29.0, 29.0

IFNbeta

--

MO000016660

cso30:c:Protein

cso30:i:CC_CellComponent

--

p55 p94

p76

true true true true

csml-variable:Double

m1636

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
1006.0, 62.0
31.0, 31.0

LPS

--

MO000016882

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m155666

10

false

infinite

0

unit false false false

--

Go back
1065.0, 977.0
30.0, 30.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p103

p34

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
903.0, 959.0
26.0, 26.0

TBK1

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30

p34 p69

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
368.0, 360.0
24.0, 24.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22 p91

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
442.0, 418.0
27.0, 27.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p22

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1142.0, 1022.0
35.0, 35.0

p50:RelA-p65:IkappaB-alpha

--

MO000038724

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p33 p56 p111

true true true true

csml-variable:Double

m16910

10

false

infinite

0

unit false false false
TRANSPATHMO000038724

--

Go back
881.0, 637.0
25.0, 25.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p27 p28 p29

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
947.0, 323.0
26.5, 26.5

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18 p23

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
986.0, 294.0
28.0, 28.0

TRAM

--

MO000041132

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p17

true true true true

csml-variable:Double

m19005

10

false

infinite

0

unit false false false
TRANSPATHMO000041132

--

Go back
436.0, 316.0
32.0, 32.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p23

p53 p56 p57

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
391.0, 335.0
26.5, 26.5

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p22

p23

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
589.0, 1245.0
32.0, 32.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p54 p66 p70

p55 p72

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
956.0, 1132.0
31.0, 31.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p103

p41

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
359.0, 671.0
26.0, 26.0

TLR8

--

MO000042007

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6 p9 p11 p13

true true true true

csml-variable:Double

m19823

10

false

infinite

0

unit false false false
TRANSPATHMO000042007

--

Go back
352.0, 860.0
24.0, 24.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p14 p93 p98 p118

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
1427.0, 293.0
26.0, 26.0

PGN

--

MO000042032

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4

true true true true

csml-variable:Double

m155701

10

false

infinite

0

unit false false false
TRANSPATHMO000042032

--

Go back
339.0, 483.0
26.0, 26.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5 p8 p10 p12 p92 p121 p142

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
956.0, 396.0
31.5, 31.5

RNASEL{activated}

--

MO000061281

cso30:c:Protein

cso30:i:CC_CellComponent

--

p75

p74

true true true true

csml-variable:Double

m36179

10

false

infinite

0

unit false false false
TRANSPATHMO000061281

--

Go back
1067.0, 1027.0
33.5, 33.5

OPN

--

MO000061307

cso30:c:Protein

cso30:i:CC_CellComponent

--

p30 p103

p34

true true true true

csml-variable:Double

m36205

10

false

infinite

0

unit false false false
TRANSPATHMO000061307

--

Go back
825.0, 261.0
30.5, 30.5

DAI

--

MO000061425

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p67

true true true true

csml-variable:Double

m36323

10

false

infinite

0

unit false false false
TRANSPATHMO000061425

--

Go back
1074.0, 274.0
31.0, 31.0

MAL

--

MO000068831

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p15 p16 p19

true true true true

csml-variable:Double

m43675

10

false

infinite

0

unit false false false
TRANSPATHMO000068831

--

Go back
725.0, 253.0
30.0, 30.0

IPS1

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p61 p62 p63

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
405.0, 277.0
29.0, 29.0

MDA-5

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p59

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
224.92713562413394, 135.68376036584698
1127.848960282282, 1673.451020997325

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
235.26394311436604, 160.01432548463578
1039.9174124843082, 1494.8636878383768

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
1204.5, 1204.0
31.5, 31.5

p50:RelA-p65{activated}

--

e100

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p68 p71

true true true true

csml-variable:Double

m102

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
789.5, 303.0
28.227462089651727, 34.564239293451095

dsRNA: DAI

--

e101

cso30:c:Complex

cso30:i:CC_Cytosol

--

p67

p69 p71

true true true true

csml-variable:Double

m103

0

false

infinite

0

unit false false false

--

Go back
783.0, 1107.0
26.0, 26.0

TBK1{activated}

--

e102

cso30:c:Protein

cso30:i:CC_CellComponent

--

p69

p70

true true true true

csml-variable:Double

m104

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
798.5, 1471.0
34.98269896193772, 18.65743944636678

IFN Type I

--

e103

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p79

p72 p122 p138

true true true true

csml-variable:Double

m105

0

false

infinite

0

unit false false false

--

Go back
869.0, 305.0
29.0, 29.0

PKR{activated}

--

e104

cso30:c:Protein

cso30:i:CC_CellComponent

--

p73

--

true true true true

csml-variable:Double

m106

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000008179

--

Go back
836.5, 221.25
38.515559293523964, 21.82548359966358

5'-triphosphate

--

e105

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p73

true true true true

csml-variable:Double

m107

0

false

infinite

0

unit false false false

--

Go back
1040.5, 485.625
39.357005758157385, 21.646353166986565

self RNA

--

e106

cso30:c:Rna

cso30:i:CC_Cytosol

--

p74

--

true true true true

csml-variable:Double

m108

0

false

infinite

0

unit false false false

--

Go back
912.0, 412.0
31.5, 31.5

RNASEL

--

e107

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p75

true true true true

csml-variable:Double

m109

10

false

infinite

0

unit false false false
TRANSPATHMO000061281

--

Go back
999.5, 488.25
41.34146341463414, 23.426829268292682

2', 5'--linked oligoadenylate

--

e108

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p75

true true true true

csml-variable:Double

m110

0

false

infinite

0

unit false false false

--

Go back
1106.5, 534.25
35.05887300252312, 19.866694701429772

small RNA cleavage products

--

e109

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

p74

--

true true true true

csml-variable:Double

m111

0

false

infinite

0

unit false false false

--

Go back
351.3827015341437, 322.0
433.89888684504945, 724.3905144785995

--

e11

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeMembrane

--

--

--

true true true true

csml-variable:Double

m11

0

false

infinite

0

unit false true false

--

Go back
225.375, 1454.5
20.042618629173987, 30.834797891036917

IFNAR

--

e110

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p77

true true true true

csml-variable:Double

m112

0

false

infinite

0

unit false false false

--

Go back
119.0, 1430.0
23.0, 23.0

IFNbeta

--

e111

cso30:c:Protein

cso30:i:CC_CellComponent

--

p76

p77

true true true true

csml-variable:Double

m113

10

false

infinite

0

unit false false false
InterProIPR000471
TRANSPATHMO000016660

--

Go back
229.375, 1490.5
20.001151063363295, 38.71190528392896

IFN beta: IFNAR

--

e112

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p77

p78

true true true true

csml-variable:Double

m114

0

false

infinite

0

unit false false false

--

Go back
1204.625, 1248.5
31.099608398600232, 38.08115314114314

MyD88: IRF-5

--

e113

cso30:c:Complex

cso30:i:CC_Cytosol

--

p80

p81 p82 p83 p84 p85 p86 p87 p88 p89

true true true true

csml-variable:Double

m115

0

false

infinite

0

unit false false false

--

Go back
1166.625, 591.5
28.739835027495424, 35.191634727545406

MyD88: IRF-4

--

e114

cso30:c:Complex

cso30:i:CC_Cytosol

--

p90

p80

true true true true

csml-variable:Double

m116

0

false

infinite

0

unit false false false

--

Go back
758.125, 544.5
19.641124974844033, 31.85047293217951

UNC93B

--

e115

cso30:c:Protein

cso30:i:CC_EndosomeMembrane

--

--

p91 p92 p93

true true true true

csml-variable:Double

m117

0

false

infinite

0

unit false false false

--

Go back
741.875, 500.5
27.578317122407782, 38.48137272894109

TLR3: UNC93B: gp96

--

e116

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p91

--

true true true true

csml-variable:Double

m118

0

false

infinite

0

unit false false false

--

Go back
761.875, 580.5
27.578317122407782, 38.48137272894109

TLR7: UNC93B: gp96

--

e117

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p92

--

true true true true

csml-variable:Double

m119

0

false

infinite

0

unit false false false

--

Go back
750.875, 773.5
26.22100385391815, 36.58744723802533

TLR9: UNC93B: gp96

--

e118

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p93

--

true true true true

csml-variable:Double

m120

0

false

infinite

0

unit false false false

--

Go back
776.25, 634.5
15.486903648269411, 35.73900841908326

gp96

--

e119

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

--

p91 p92 p93

true true true true

csml-variable:Double

m121

0

false

infinite

0

unit false false false

--

Go back
1027.0, 163.5
33.760000000000005, 25.320000000000004

TLR4

--

e12

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p1

true true true true

csml-variable:Double

m12

0

false

infinite

0

unit false false false

--

Go back
657.625, 954.5
29.148100316613892, 35.69155140809865

A type CpG ODN: TLR9

--

e120

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

--

p100

true true true true

csml-variable:Double

m122

0

false

infinite

0

unit false false false

--

Go back
601.625, 982.5
29.148100316613892, 35.69155140809865

Type B CpG ODN: TLR9

--

e121

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

--

p99 p110

true true true true

csml-variable:Double

m123

0

false

infinite

0

unit false false false

--

Go back
681.5, 924.0
28.36942558267572, 39.585244999082406

A type CpG ODN: TLR9: MyD88

--

e122

cso30:c:Complex

cso30:i:CC_Cytosol

--

p100

p101 p145

true true true true

csml-variable:Double

m124

0

false

infinite

0

unit false false false

--

Go back
738.5, 959.0
27.116980503249458, 33.20446592234628

IRAK-4: TRAF6

--

e123

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p101 p114

true true true true

csml-variable:Double

m125

0

false

infinite

0

unit false false false

--

Go back
730.5, 1036.0
26.088151974670886, 31.944675887352115

IRAK-4: TRAF6{activated}

--

e124

cso30:c:Complex

cso30:i:CC_Cytosol

--

p101 p114

p102 p111

true true true true

csml-variable:Double

m126

0

false

infinite

0

unit false false false

--

Go back
885.5, 1024.0
28.377316938887873, 39.59625619379703

IRAK-1: TRAF3: OPN: IRF-7

--

e125

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p102

true true true true

csml-variable:Double

m127

0

false

infinite

0

unit false false false

--

Go back
869.5, 1092.0
28.377316938887873, 39.59625619379703

IRAK-1: TRAF3: OPN: IRF-7

--

e126

cso30:c:Complex

cso30:i:CC_Cytosol

--

p102

p103

true true true true

csml-variable:Double

m128

0

false

infinite

0

unit false false false

--

Go back
573.5, 1414.125
37.41698530891528, 23.07380760716442

IFNL

--

e127

cso30:c:Protein

cso30:i:CC_Cytosol

--

p104

--

true true true true

csml-variable:Double

m129

0

false

infinite

0

unit false false false

--

Go back
789.5, 1652.125
37.80338096196418, 23.312084926544575

IFNW1

--

e128

cso30:c:Protein

cso30:i:CC_Cytosol

--

p105

--

true true true true

csml-variable:Double

m130

0

false

infinite

0

unit false false false

--

Go back
762.875, 905.5
26.22100385391815, 36.58744723802533

IRAK4:TRAF6: BTK

--

e129

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p106

true true true true

csml-variable:Double

m131

0

false

infinite

0

unit false false false

--

Go back
1296.0, 1677.5
32.31999999999999, 24.240000000000002

TLR5

--

e13

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p2

true true true true

csml-variable:Double

m13

0

false

infinite

0

unit false false false

--

Go back
894.875, 917.5
26.22100385391815, 36.58744723802533

IRAK4:TRAF6: BTK

--

e130

cso30:c:Complex

cso30:i:CC_Cytosol

--

p106

p107 p112

true true true true

csml-variable:Double

m132

0

false

infinite

0

unit false false false

--

Go back
630.5, 965.0
27.217287575701956, 37.97761057074692

Type B CpG ODN: TLR9: MyD88

--

e131

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p110

p106 p144 p146

true true true true

csml-variable:Double

m133

0

false

infinite

0

unit false false false

--

Go back
64.0, 1211.5
47.26057906458797, 16.54120267260579

self DNA

--

e132

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p95

true true true true

csml-variable:Double

m134

0

false

infinite

0

unit false false false

--

Go back
141.5, 1238.0
29.99116813864356, 36.72387935344109

LL37: self DNA

--

e133

cso30:c:Complex

cso30:i:CC_Extracellular

--

p95

p96

true true true true

csml-variable:Double

m135

0

false

infinite

0

unit false false false

--

Go back
73.5, 1299.125
29.012879855101634, 17.891275910646005

HMGB1

--

e134

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p96

true true true true

csml-variable:Double

m136

0

false

infinite

0

unit false false false

--

Go back
142.875, 1282.5
25.26614975224812, 35.25509267755552

LL37: self DNA: HMGB1

--

e135

cso30:c:Complex

cso30:i:CC_Extracellular

--

p96

p115 p116

true true true true

csml-variable:Double

m137

0

false

infinite

0

unit false false false

--

Go back
447.375, 1037.5
24.36072056239016, 37.47803163444639

RAGE

--

e136

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p98

p97

true true true true

csml-variable:Double

m138

0

false

infinite

0

unit false false false

--

Go back
384.375, 1021.5
23.25, 45.0

LL37: self DNA: HMGB1: RAGE

--

e137

cso30:c:Complex

cso30:i:CC_Cytosol

--

p97

p98

true true true true

csml-variable:Double

m139

0

false

infinite

0

unit false false false

--

Go back
516.875, 1015.5
29.472242613323544, 41.12405946045146

LL37: self DNA: HMGB1: TLR9

--

e138

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p98

p113

true true true true

csml-variable:Double

m140

0

false

infinite

0

unit false false false

--

Go back
559.875, 1001.5
31.03473114332905, 43.304276013947515

LL37: self DNA: HMGB1: TLR9: MyD88

--

e139

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p113

p114

true true true true

csml-variable:Double

m141

0

false

infinite

0

unit false false false

--

Go back
1075.5, 152.0
29.778870188301948, 36.46392267955341

LPS: TLR4

--

e14

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p1

p15 p17

true true true true

csml-variable:Double

m14

0

false

infinite

0

unit false false false

--

Go back
314.875, 1206.5
25.26614975224812, 35.25509267755552

LL37: self DNA: HMGB1

--

e140

cso30:c:Complex

cso30:i:CC_Extracellular

--

p115

p97

true true true true

csml-variable:Double

m142

0

false

infinite

0

unit false false false

--

Go back
52.0, 1121.5
24.307692307692307, 36.46153846153847

DNA-specific IgG antibody

--

e141

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p116

true true true true

csml-variable:Double

m143

0

false

infinite

0

unit false false false

--

Go back
106.875, 1045.5
27.041704899981646, 37.732611488346485

LL37: self DNA: HMGB1: DNA-specific IgG antibody

--

e142

cso30:c:Complex

cso30:i:CC_Extracellular

--

p116

p117

true true true true

csml-variable:Double

m144

0

false

infinite

0

unit false false false

--

Go back
230.375, 1115.5
27.148066783831283, 41.76625659050967

FCgammaRIIA

--

e143

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p118

p117

true true true true

csml-variable:Double

m145

0

false

infinite

0

unit false false false

--

Go back
228.375, 1033.5
23.25, 45.0

LL37: self DNA: HMGB1: DNA-specific IgG antibody: FCgammaRIIA

--

e144

cso30:c:Complex

cso30:i:CC_Extracellular

--

p117

p118

true true true true

csml-variable:Double

m146

0

false

infinite

0

unit false false false

--

Go back
351.875, 969.5
32.25, 45.0

LL37: self DNA: HMGB1: DNA-specific IgG antibody: TLR9

--

e145

cso30:c:Complex

cso30:i:CC_Cytosol

--

p118

--

true true true true

csml-variable:Double

m147

0

false

infinite

0

unit false false false

--

Go back
131.375, 413.5
25.725471698113203, 28.06415094339623

snRNA

--

e146

cso30:c:RnaOther

cso30:i:CC_Extracellular

--

--

p121

true true true true

csml-variable:Double

m148

0

false

infinite

0

unit false false false

--

Go back
337.625, 410.5
24.600024995834033, 30.122479586735544

snRNA: TLR7

--

e147

cso30:c:Complex

cso30:i:CC_Cytosol

--

p121

p122

true true true true

csml-variable:Double

m149

0

false

infinite

0

unit false false false

--

Go back
88.0, 437.5
24.461538461538463, 36.69230769230769

auto-antibody

--

e148

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p121

true true true true

csml-variable:Double

m150

0

false

infinite

0

unit false false false

--

Go back
229.5, 1595.0
21.803990352992763, 42.201271650953736

BDCA2ligand: BDCA2

--

e149

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p123

true true true true

csml-variable:Double

m151

0

false

infinite

0

unit false false false

--

Go back
1300.625, 1710.5
23.260914847525413, 28.482752874520912

flagellin: TLR5

--

e15

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p2

--

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
224.5, 1755.0
22.001096250822187, 42.5827669370752

ILT7 ligand: ILT7

--

e150

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p124

true true true true

csml-variable:Double

m152

0

false

infinite

0

unit false false false

--

Go back
230.5, 1645.0
26.68067535327583, 37.22884933015232

BDCA2ligand: BDCA2: IgE: FCepsilonRIgamma

--

e151

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p123

p127

true true true true

csml-variable:Double

m153

0

false

infinite

0

unit false false false

--

Go back
218.5, 1689.0
19.55426441569831, 37.84696338522254

IgE: FCepsilonRIgamma

--

e152

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p123 p124

true true true true

csml-variable:Double

m154

0

false

infinite

0

unit false false false

--

Go back
255.5, 1746.0
25.99412736281886, 36.27087538997981

ILT7 ligand: ILT7: IgE: FCepsilonRIgamma

--

e153

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p124

p128

true true true true

csml-variable:Double

m155

0

false

infinite

0

unit false false false

--

Go back
454.5, 1765.0
19.764963823722866, 38.25476869107652

ligand: DAP12

--

e154

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p125 p126 p135 p136 p137

true true true true

csml-variable:Double

m156

0

false

infinite

0

unit false false false

--

Go back
364.375, 1761.5
23.25, 45.0

ligand: NKp44

--

e155

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p125

true true true true

csml-variable:Double

m157

0

false

infinite

0

unit false false false

--

Go back
554.375, 1760.5
19.763264634948474, 38.25147993860995

ligand: Siglec-H

--

e156

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p126

true true true true

csml-variable:Double

m158

0

false

infinite

0

unit false false false

--

Go back
402.875, 1732.5
27.238988805285373, 38.00789135621215

ligand: NKp44: ligand: DAP12

--

e157

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

p125

p130

true true true true

csml-variable:Double

m159

0

false

infinite

0

unit false false false

--

Go back
490.875, 1717.5
26.899660488162965, 37.53440998348321

ligand: Siglec-H: ligand: DAP12

--

e158

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p126

p129

true true true true

csml-variable:Double

m160

0

false

infinite

0

unit false false false

--

Go back
376.125, 1597.5
17.98062990541356, 29.157778224994974

PTKs

--

e159

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p127 p128 p129 p130 p133

true true true true

csml-variable:Double

m161

0

false

infinite

0

unit false false false

--

Go back
1376.5, 1652.375
38.91915641476273, 25.29745166959578

flagellin

--

e16

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p2

true true true true

csml-variable:Double

m16

0

false

infinite

0

unit false false false

--

Go back
375.125, 1645.5
17.98062990541356, 29.157778224994974

PTKs{activated}

--

e160

cso30:c:Protein

cso30:i:CC_Cytosol

--

p127 p128 p129 p130 p133

p131

true true true true

csml-variable:Double

m162

0

false

infinite

0

unit false false false

--

Go back
524.25, 1587.5
14.647801683816652, 33.80261927034612

Syk{activated}

--

e161

cso30:c:Protein

cso30:i:CC_Cytosol

--

p131

p132

true true true true

csml-variable:Double

m163

0

false

infinite

0

unit false false false

--

Go back
524.25, 1635.5
14.647801683816652, 33.80261927034612

Syk

--

e162

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p131

true true true true

csml-variable:Double

m164

0

false

infinite

0

unit false false false

--

Go back
461.625, 1521.5
29.63801866355607, 36.29145142476254

BLNK: BCAP

--

e163

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p132

true true true true

csml-variable:Double

m165

0

false

infinite

0

unit false false false

--

Go back
661.625, 1521.5
29.63801866355607, 36.29145142476254

BLNK: BCAP{activated}

--

e164

cso30:c:Complex

cso30:i:CC_Cytosol

--

p132

p55 p72 p78 p94 p105 p108 p109 p122

true true true true

csml-variable:Double

m166

0

false

infinite

0

unit false false false

--

Go back
228.375, 1537.5
23.25, 45.0

FcgammaRIIA

--

e165

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p133

true true true true

csml-variable:Double

m167

0

false

infinite

0

unit false false false

--

Go back
793.625, 1738.5
28.478545242459592, 34.871688051991335

PDC-TREM: plexin A1

--

e166

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p139

p134

true true true true

csml-variable:Double

m168

0

false

infinite

0

unit false false false

--

Go back
865.5, 1684.375
36.91564147627417, 23.99516695957821

semaphorin 6D

--

e167

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p134

true true true true

csml-variable:Double

m169

0

false

infinite

0

unit false false false

--

Go back
744.375, 1749.5
23.25, 45.0

semaphorin 6D: PDC-TREM: plexin A1

--

e168

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p134

p135 p136 p137

true true true true

csml-variable:Double

m170

0

false

infinite

0

unit false false false

--

Go back
638.0, 1686.0
27.0, 27.0

PI3K{activated}

--

e169

cso30:c:Protein

cso30:i:CC_CellComponent

--

p135

p138

true true true true

csml-variable:Double

m171

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
1418.5, 193.125
35.88, 26.909999999999993

Lp

--

e17

cso30:c:Protein

cso30:i:CC_Extracellular

--

--

p3

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
642.125, 1568.5
19.670909639766553, 31.898772388810627

ERK1

--

e170

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p136

true true true true

csml-variable:Double

m172

0

false

infinite

0

unit false false false

--

Go back
649.125, 1626.5
21.629251358422216, 35.0744616623063

ERK2

--

e171

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

--

p137

true true true true

csml-variable:Double

m173

0

false

infinite

0

unit false false false

--

Go back
610.125, 1592.5
19.670909639766553, 31.898772388810627

ERK1{activated}

--

e172

cso30:c:Protein

cso30:i:CC_Cytosol

--

p136

p138

true true true true

csml-variable:Double

m174

0

false

infinite

0

unit false false false

--

Go back
605.125, 1646.5
21.629251358422216, 35.0744616623063

ERK2{activated}

--

e173

cso30:c:Protein

cso30:i:CC_Cytoplasm

--

p137

p138

true true true true

csml-variable:Double

m175

0

false

infinite

0

unit false false false

--

Go back
860.375, 1730.5
22.807117750439367, 35.08787346221441

PDC-TREM

--

e174

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p139

true true true true

csml-variable:Double

m176

0

false

infinite

0

unit false false false

--

Go back
920.5, 1724.125
31.240000000000002, 23.43

plexin A1

--

e175

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

p139

true true true true

csml-variable:Double

m177

0

false

infinite

0

unit false false false

--

Go back
241.375, 1364.5
20.6060622670467, 39.88270116202587

nucleortide: P2Y

--

e176

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p140

p55

true true true true

csml-variable:Double

m178

0

false

infinite

0

unit false false false

--

Go back
58.5, 1402.625
34.0978886756238, 18.75383877159309

ADP

--

e177

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p140

true true true true

csml-variable:Double

m179

0

false

infinite

0

unit false false false

--

Go back
241.375, 1404.5
20.75087873462214, 31.924428822495603

P2Y

--

e178

cso30:c:Protein

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p140

true true true true

csml-variable:Double

m180

0

false

infinite

0

unit false false false

--

Go back
253.375, 1256.5
20.6060622670467, 39.88270116202587

ligand: BCR

--

e179

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p141

true true true true

csml-variable:Double

m182

0

false

infinite

0

unit false false false

--

Go back
1280.625, 193.5
30.029953341109817, 36.77137143809365

TLR1: TLR2

--

e18

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p3

true true true true

csml-variable:Double

m18

0

false

infinite

0

unit false false false

--

Go back
253.375, 1308.5
20.6060622670467, 39.88270116202587

ligand: BCR{activated}

--

e180

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p141

p55 p72 p78 p94 p104 p105 p108 p109 p122

true true true true

csml-variable:Double

m185

0

false

infinite

0

unit false false false

--

Go back
53.5, 1325.625
36.247600767754314, 19.936180422264876

self RNA

--

e181

cso30:c:Rna

cso30:i:CC_Extracellular

--

--

p141 p142

true true true true

csml-variable:Double

m186

0

false

infinite

0

unit false false false

--

Go back
335.625, 445.5
23.799825029161813, 29.142642892851192

self RNA: TLR7

--

e182

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p142

--

true true true true

csml-variable:Double

m187

0

false

infinite

0

unit false false false

--

Go back
869.5, 1246.0
37.110726643598625, 19.792387543252595

IL-12

--

e183

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p143

true true true true

csml-variable:Double

m188

0

false

infinite

0

unit false false false

--

Go back
866.5, 1193.125
34.4103441336285, 21.219712215737573

IL-12

--

e184

cso30:c:Protein

cso30:i:CC_Cytosol

--

p143

--

true true true true

csml-variable:Double

m189

0

false

infinite

0

unit false false false

--

Go back
739.5, 1190.125
32.06782048701952, 19.77515596699537

IFN-gamma

--

e185

cso30:c:Protein

cso30:i:CC_Cytosol

--

p145

--

true true true true

csml-variable:Double

m190

0

false

infinite

0

unit false false false

--

Go back
832.5, 1296.0
31.660899653979243, 16.885813148788927

IFN-gamma

--

e186

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p145

true true true true

csml-variable:Double

m191

0

false

infinite

0

unit false false false

--

Go back
697.0, 1211.5
21.538461538461537, 32.30769230769231

antibody

--

e187

cso30:c:Protein

cso30:i:CC_Cytosol

--

p146

--

true true true true

csml-variable:Double

m192

0

false

infinite

0

unit false false false

--

Go back
813.5, 1346.0
37.88927335640139, 20.207612456747405

antibody

--

e188

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

--

p146

true true true true

csml-variable:Double

m193

0

false

infinite

0

unit false false false

--

Go back
1279.875, 245.5
32.25, 45.0

Lp: TLR1: TLR2

--

e19

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p3

p19

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
224.92713562413394, 135.68376036584698
1127.848960282282, 1673.451020997325

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
161.5, 866.0
45.0, 12.0

CpG ODN

--

e20

cso30:c:Dna

cso30:i:CC_Extracellular

--

--

p14

true true true true

csml-variable:Double

m20

0

false

infinite

0

unit false false false

--

Go back
1286.625, 303.5
27.27007998666889, 33.39193467755374

TLR6: TLR2

--

e21

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

p4

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
1284.875, 343.5
29.472242613323544, 41.12405946045146

PGN: TLR6: TLR2

--

e22

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p4

--

true true true true

csml-variable:Double

m22

0

false

infinite

0

unit false false false

--

Go back
435.5, 588.625
41.5067178502879, 22.828694817658352

ssRNA

--

e23

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p5 p6

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
342.625, 512.5
25.759498416930516, 31.54224295950675

ssRNA: TLR7

--

e24

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p5

p24

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
357.625, 698.5
28.59285952341276, 35.01166472254625

ssRNA: TLR8

--

e25

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p6

p25

true true true true

csml-variable:Double

m25

0

false

infinite

0

unit false false false

--

Go back
345.625, 890.5
28.568363606065656, 34.98166972171304

CpG DNA: TLR9

--

e26

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p7

p26

true true true true

csml-variable:Double

m26

0

false

infinite

0

unit false false false

--

Go back
111.5, 552.25
40.13036164844407, 22.74053826745164

imiquimod

--

e27

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p8 p9

true true true true

csml-variable:Double

m27

0

false

infinite

0

unit false false false

--

Go back
344.625, 549.5
24.510206632227966, 30.01249791701383

imidazoquinoline: TLR7

--

e28

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p8

--

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
348.625, 733.5
30.209590068321948, 36.99133477753708

imidazoquinoline: TLR8

--

e29

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p9

--

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
247.48411482977951, 158.73404991126455
1082.735001870991, 1627.3504419064905

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
124.5, 676.25
39.802354920100925, 22.554667788057188

R-848

--

e30

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p10 p11

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
341.625, 774.5
28.960298283619398, 35.46158973504416

R-848: TLR8

--

e31

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p11

--

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
350.625, 591.5
27.53953507748708, 33.72187968671888

R-848: TLR7

--

e32

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p10

--

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
120.5, 825.25
38.313708999158955, 21.711101766190076

guanosine analogues

--

e33

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p12 p13

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
358.625, 631.5
26.78832694550908, 32.80203299450091

guanosine analogues: TLR7

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p12

--

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
342.625, 819.5
26.69034327612065, 32.68205299116814

guanosine analogues: TLR8

--

e35

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p13

--

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
441.5, 814.0
45.0, 12.0

CpG ss-DNA

--

e36

cso30:c:Dna

cso30:i:CC_EndosomeLumen

--

--

p7

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
341.625, 926.5
29.148100316613892, 35.69155140809865

CpG ODN: TLR9

--

e37

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p14

--

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
1133.875, 139.5
30.829555881813178, 43.017984951367225

LPS: TLR4: MAL

--

e38

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p15

--

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
1177.875, 123.5
32.25, 45.0

LPS: TLR4: MAL: MyD88

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p16

--

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
289.2145263602241, 199.07205661574545
999.2741788101021, 1546.674428497528

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
983.875, 125.5
32.25, 45.0

LPS: TLR4: TRAM

--

e40

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p17

p18

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
943.875, 140.5
32.25, 45.0

LPS: TLR4: TRAM: TRIF

--

e41

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p18

--

true true true true

csml-variable:Double

m41

0

false

infinite

0

unit false false false

--

Go back
1287.875, 393.5
32.25, 45.0

Lp: TLR1: TLR2: MAL

--

e42

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p19

p20

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
1287.875, 453.5
32.25, 45.0

Lp: TLR1: TLR2: MAL: MyD88

--

e43

cso30:c:Complex

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

p20

--

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
350.5, 383.0
27.419096817197136, 33.57440426595568

poly I:C: TLR3

--

e44

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p21

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
127.5, 376.25
40.23128679562657, 22.797729184188395

Poly I:C: TLR3

--

e45

cso30:c:SmallMolecule

cso30:i:CC_Extracellular

--

--

p21 p143

true true true true

csml-variable:Double

m45

0

false

infinite

0

unit false false false

--

Go back
688.875, 407.5
29.74054872453661, 41.498440080748765

ssRNA: TLR7: MyD88

--

e46

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p24 p27 p45

--

true true true true

csml-variable:Double

m46

0

false

infinite

0

unit false false false

--

Go back
764.875, 671.5
29.472242613323544, 41.12405946045146

ssRNA: TLR8: MyD88

--

e47

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p25 p28 p46

--

true true true true

csml-variable:Double

m47

0

false

infinite

0

unit false false false

--

Go back
733.875, 820.5
28.517388511653515, 39.791704899981646

CpG DNA: TLR9: MyD88

--

e48

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p26 p29 p31

--

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
711.875, 449.5
32.25, 45.0

ssRNA: TLR7: MyD88: IRAK-1: IRAK-4: TRAF6: BTK

--

e49

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p27

p45

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
351.3827015341437, 322.0
433.89888684504945, 724.3905144785995

--

e5

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndosomeLumen

--

--

--

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false true false

--

Go back
746.4311828958773, 1211.9772663234394
486.8584063562004, 451.1830696139516

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
799.0155172881672, 1222.6696491562773
284.68070688239663, 437.28626048826567

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
752.7775680811538, 1217.9992169445698
474.1656359856477, 439.13916837169006

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
753.6841945361931, 1218.9256708862822
472.3523830755686, 437.28626048826567

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
746.4311828958773, 1211.9772663234394
486.8584063562004, 451.1830696139516

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
746.4311828958773, 1211.9772663234394
486.8584063562004, 451.1830696139516

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
753.6841945361931, 1218.9256708862822
472.3523830755686, 437.28626048826567

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
1101.8287532713528, 1397.2680546659249
30.41623818363828, 28.136870536944837

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
1022.0456252278782, 1526.971606505664
86.1295132287505, 79.67503898726874

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
746.4311828958773, 1211.9772663234394
486.8584063562004, 451.1830696139516

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
351.3827015341437, 322.0
433.89888684504945, 724.3905144785995

--

e6

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Endosome

--

--

--

true true true true

csml-variable:Double

m6

0

false

infinite

0

unit false true false

--

Go back
861.1809699103356, 1412.4792943034831
15.418090366017243, 7.585873929804072

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
860.6661162308517, 1389.8564231322255
52.772502147109286, 97.06790072319058

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
882.8048244486638, 1452.9900170985288
8.237658871743886, 8.417812528840377

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
763.875, 713.5
32.25, 45.0

ssRNA: TLR8: MyD88: IRAK-1: IRAK-4: TRAF6: BTK

--

e63

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p46

true true true true

csml-variable:Double

m63

0

false

infinite

0

unit false false false

--

Go back
703.875, 857.5
32.25, 45.0

CpG DNA: TLR9: MyD88: IRAK-1: IRAK-4: TRAF6: BTK

--

e64

cso30:c:Complex

cso30:i:CC_EndosomeMembrane

--

p29

p31

true true true true

csml-variable:Double

m64

0

false

infinite

0

unit false false false

--

Go back
1199.0, 975.0
34.0, 34.0

MAPKs{activated}

--

e65

cso30:c:Protein

cso30:i:CC_CellComponent

--

p36 p57

p51 p52

true true true true

csml-variable:Double

m65

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
1018.7158882363736, 681.5
26.29202605982749, 36.686547990456965

IRAK-1: IRAK4:TRAF6: BTK: IRF-7

--

e66

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

p42

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false false false

--

Go back
1018.3844512754633, 761.5
29.74054872453661, 41.498440080748765

IRAK-1: IRAK4:TRAF6: BTK: IRF-7{ub}

--

e67

cso30:c:Complex

cso30:i:CC_Cytosol

--

p42

p32

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false false false

--

Go back
956.875, 1003.5
29.472242613323544, 41.12405946045146

IRAK1: IRF-7{ub}: TRAF3: TABK1: IKK-alpha: OPN: PI3K

--

e68

cso30:c:Complex

cso30:i:CC_Cytosol

--

p34

p30

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false false false

--

Go back
955.875, 833.5
32.25, 45.0

IRAK1: IRF-7{ub}

--

e69

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p34

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false false false

--

Go back
239.0227822017231, 142.08945768804384
1052.1287998554285, 1523.443275346338

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
1075.875, 833.5
29.472242613323544, 41.12405946045146

IRAK-1: TRAF6: BTK

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p32

p40 p35

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false false false

--

Go back
1199.0, 886.0
32.0, 32.0

TAK1{activated}

--

e71

cso30:c:Protein

cso30:i:CC_CellComponent

--

p35 p107

p33 p36

true true true true

csml-variable:Double

m74

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
951.875, 626.5
25.060974490732246, 34.96880161497523

IRAK-1: IRAK4:TRAF6: BTK{activated}

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p45 p46 p31

p39

true true true true

csml-variable:Double

m73

0

false

infinite

0

unit false false false

--

Go back
1196.0, 792.0
31.5, 31.5

IRF-5{activated}

--

e73

cso30:c:Protein

cso30:i:CC_CellComponent

--

p40 p112

--

true true true true

csml-variable:Double

m75

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007700

--

Go back
984.0, 1232.0
31.0, 31.0

IRF-7{ub}{p}

--

e74

cso30:c:Protein

cso30:i:CC_CellComponent

--

p41

p38 p43 p44 p47

true true true true

csml-variable:Double

m76

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
913.5, 1422.0
36.79930795847751, 19.62629757785467

IFNL

--

e75

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p44 p83

p104

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
589.5, 1084.0
28.984951367223346, 40.444118186823275

TRAF3: TBK1: IKK-i

--

e76

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p53 p64

true true true true

csml-variable:Double

m78

0

false

infinite

0

unit false false false

--

Go back
1124.5, 1300.0
31.5, 31.5

p50:RelA-p65{activated}

--

e77

cso30:c:Protein

cso30:i:CC_CellComponent

--

p48

p49 p50

true true true true

csml-variable:Double

m79

10

false

infinite

0

unit false false false
TRANSPATHMO000016632

--

Go back
589.5, 1132.0
28.984951367223346, 40.444118186823275

TRAF3: TBK1: IKK-i{activated}

--

e78

cso30:c:Complex

cso30:i:CC_Cytosol

--

p53

p54

true true true true

csml-variable:Double

m80

0

false

infinite

0

unit false false false

--

Go back
308.5, 258.0
24.217926186291734, 37.258347978910365

RIG-1

--

e79

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p58

true true true true

csml-variable:Double

m81

0

false

infinite

0

unit false false false

--

Go back
242.78162128908036, 168.97675938293176
1009.3196946264908, 1497.5826843540028

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
406.0, 30.0
27.0, 27.0

dsRNA

--

e80

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p59 p60 p67 p73

true true true true

csml-variable:Double

m82

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
344.375, 225.5
23.25, 45.0

dsRNA: RIG-1

--

e81

cso30:c:Complex

cso30:i:CC_Cytosol

--

p58

p61

true true true true

csml-variable:Double

m83

0

false

infinite

0

unit false false false

--

Go back
477.625, 254.5
29.148100316613892, 35.69155140809865

dsRNA: MDA-5

--

e82

cso30:c:Complex

cso30:i:CC_Cytosol

--

p59

p62

true true true true

csml-variable:Double

m84

0

false

infinite

0

unit false false false

--

Go back
592.625, 265.5
31.00979003499417, 37.97117147142143

dsRNA: LGP2

--

e83

cso30:c:Complex

cso30:i:CC_Cytosol

--

p60

p63

true true true true

csml-variable:Double

m85

0

false

infinite

0

unit false false false

--

Go back
538.5, 289.125
35.19521030388408, 21.703713020728518

LGP2

--

e84

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p60

true true true true

csml-variable:Double

m86

0

false

infinite

0

unit false false false

--

Go back
760.1498029784049, 259.6225488964334
0.5854327073220948, 0.585432707322094

--

e85

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialCentromere

--

--

--

true true true true

csml-variable:Double

m87

0

false

infinite

0

unit false true false

--

Go back
758.6130421216847, 255.26839313572538
3.7504282812821743, 6.750770906307896

--

e86

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialChromosome

--

--

--

true true true true

csml-variable:Double

m88

0

false

infinite

0

unit false true false

--

Go back
747.7168642745708, 230.5373712948518
32.75457098283915, 51.37712948517912

--

e87

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialInnerMembrane

--

--

--

true true true true

csml-variable:Double

m89

0

false

infinite

0

unit false true false

--

Go back
742.433868954758, 225.98078783151323
43.32056162246464, 60.4902964118561

--

e88

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialIntermembraneSpace

--

--

--

true true true true

csml-variable:Double

m90

0

false

infinite

0

unit false true false

--

Go back
742.433868954758, 225.98078783151323
43.32056162246464, 60.4902964118561

--

e89

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialEnvelope

--

--

--

true true true true

csml-variable:Double

m91

0

false

infinite

0

unit false true false

--

Go back
283.8051921886993, 252.1459190256952
1004.7115965739548, 1477.942262708966

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
747.8489391575661, 230.6694461778471
32.490421216848524, 51.112979719188424

--

e90

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialLumen

--

--

--

true true true true

csml-variable:Double

m92

0

false

infinite

0

unit false true false

--

Go back
747.8489391575661, 230.6694461778471
32.490421216848524, 51.112979719188424

--

e91

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialMatrix

--

--

--

true true true true

csml-variable:Double

m93

0

false

infinite

0

unit false true false

--

Go back
742.433868954758, 225.98078783151323
43.32056162246464, 60.4902964118561

--

e92

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Mitochondria

--

--

--

true true true true

csml-variable:Double

m94

0

false

infinite

0

unit false true false

--

Go back
742.3017940717627, 225.84871294851797
43.584711388455275, 60.75444617784674

--

e93

cso30:c:EntityBiologicalCompartment

cso30:i:CC_MitochondrialOuterMembrane

--

--

--

true true true true

csml-variable:Double

m95

0

false

infinite

0

unit false true false

--

Go back
621.625, 222.5
29.278745209131817, 35.851524745875686

dsRNA: RIG-1: IPS1

--

e94

cso30:c:Complex

cso30:i:CC_Cytosol

--

p61

p64

true true true true

csml-variable:Double

m96

0

false

infinite

0

unit false false false

--

Go back
618.625, 355.5
27.629353441093148, 33.83186135644059

dsRNA: MDA-5: IPS1

--

e95

cso30:c:Complex

cso30:i:CC_Cytosol

--

p62

--

true true true true

csml-variable:Double

m97

0

false

infinite

0

unit false false false

--

Go back
690.625, 312.5
26.028953507748703, 31.872187968671888

dsRNA: LGP2: IPS1

--

e96

cso30:c:Complex

cso30:i:CC_Cytosol

--

p63

--

true true true true

csml-variable:Double

m98

0

false

infinite

0

unit false false false

--

Go back
387.875, 1185.5
32.44728390530372, 45.27527986786566

dsRNA: RIG1: IPS1: TRAF3: TBK1: IKK-i

--

e97

cso30:c:Complex

cso30:i:CC_Cytosol

--

p64

p65

true true true true

csml-variable:Double

m99

0

false

infinite

0

unit false false false

--

Go back
459.875, 1205.5
32.25, 45.0

FADD: caspase-8

--

e98

cso30:c:Complex

cso30:i:CC_Cytosol

--

--

p65

true true true true

csml-variable:Double

m100

0

false

infinite

0

unit false false false

--

Go back
463.875, 1257.5
32.25, 45.0

FADD: caspase-8{activated}

--

e99

cso30:c:Complex

cso30:i:CC_Cytosol

--

p65

p66 p68

true true true true

csml-variable:Double

m101

0

false

infinite

0

unit false false false

--

Go back
1077.0, 65.0
25.0, 25.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016882 e12

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m155666*m12*0.1

nodelay

--

true

0

false

PMID: 18641647, 9237759, 11323673, 10364168 The leucine-rich repeats of the TLR ectodomains bind to pathogen-associated molecular patterns (PAMPs), such as the bacterial cell-wall component lipopolysaccharide (a ligand of TLR4), bacterial flagellin (a ligand of TLR5), and lipoprotein and peptidoglycan (which are recognized by TLR2 complexed with TLR1 or TLR6).

Go back
219.0, 595.0
25.0, 25.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e30 MO000042126

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c28 : 1
stoichiometry:c30 : 1
stoichiometry:c31 : 1

m30*m19940*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.

Go back
604.0, 864.0
23.0, 23.0

p100

p100

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e120 MO000016573

e122

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c293 : 1
stoichiometry:c294 : 1
stoichiometry:c292 : 1

m122*m1572*0.1

nodelay

--

true

0

false

PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production.

Go back
686.0, 982.0
27.0, 27.0

p101

p101

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e123 e122

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c295 : 1
stoichiometry:c297 : 1
stoichiometry:c296 : 1

m125*m124*0.1

nodelay

--

true

0

false

PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production.

Go back
819.0, 1031.0
25.0, 25.0

p102

p102

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e125 e124

e126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c298 : 1
stoichiometry:c300 : 1
stoichiometry:c299 : 1

m127*m126*0.1

nodelay

--

true

0

false

PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
923.0, 1087.0
25.0, 25.0

p103

p103

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e126

MO000041457 MO000016963 MO000061307 MO000000213

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c301 : 1
stoichiometry:c302 : 1
stoichiometry:c303 : 1
stoichiometry:c304 : 1
stoichiometry:c305 : 1

m128*0.1

nodelay

--

true

0

false

PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
651.0, 1395.0
25.0, 25.0

p104

p104

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e75 e180

e127

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c306 : 1
stoichiometry:c438 : 1
stoichiometry:c281 : 1

m77*0.1

nodelay

--

true

0

false

PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL?6.

Go back
796.0, 1612.0
23.0, 23.0

p105

p105

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G012384 e164 e180

e128

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c307 : 1
stoichiometry:c395 : 1
stoichiometry:c440 : 1
stoichiometry:c308 : 1

m95135*0.1

nodelay

--

true

0

false

PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 This ITAM-mediated pathway potently inhibits type I interferon (IFN) and cytokine production by pDCs in response to Toll-like receptor (TLR) activation. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL-6.

Go back
849.0, 925.0
22.0, 22.0

p106

p106

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e129 e131

e130

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c311 : 1
stoichiometry:c321 : 1
stoichiometry:c309 : 1

m131*m133*0.1

nodelay

--

true

0

false

PMID: 18641647, 15591070, 15815647, 16864658 Conversely, liposome or particle encapsidation of B-type CpG ODNs allows their retention in early endosomes and the subsequent induction of much higher levels of type I IFNs and lower levels of IL-6 and TNF and impaired pDC maturation, which supports the important link between the physical size of TLR9 ligands and their stimulatory capacity.

Go back
1139.0, 887.0
25.0, 25.0

p107

p107

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e130

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c312 : 1
stoichiometry:c314 : 1
stoichiometry:c313 : 1

m1573*m132*0.1

nodelay

--

true

0

false

PMID: 18641647 This presumably activates a different set of signal mediators, particularly NF-kappaB (nuclear factor-kappaB) and probably MAPKs (mitogen-activated protein kinases) and IRF5, and thereby leads to distinct outcomes of pDC activation without high levels of IFN production.

Go back
1038.0, 1674.0
28.0, 28.0

p108

p108

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010329 e164 e180

MO000000289

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c317 : 1
stoichiometry:c396 : 1
stoichiometry:c441 : 1
stoichiometry:c315 : 1

m93309*0.1

nodelay

--

true

0

false

PMID: 18641647 Interestingly, when A-type CpG ODNs are disrupted into monomeric structures, they fail to be retained in the early endosome and to induce high amounts of type I IFN production, but instead rapidly traffic to late endosomes and induce maturation and production of IL-6 and TNF. PMID: 18641647 This ITAM-mediated pathway potently inhibits type I interferon (IFN) and cytokine production by pDCs in response to Toll-like receptor (TLR) activation. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL-6.

Go back
1142.0, 1650.0
27.0, 27.0

p109

p109

cso30:i:ME_Translation

cso30:i:CC_Cytoplasm

--

G010262 e164 e180

MO000007384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c318 : 1
stoichiometry:c397 : 1
stoichiometry:c442 : 1
stoichiometry:c316 : 1

m93248*0.1

nodelay

--

true

0

false

PMID: 18641647 Interestingly, when A-type CpG ODNs are disrupted into monomeric structures, they fail to be retained in the early endosome and to induce high amounts of type I IFN production, but instead rapidly traffic to late endosomes and induce maturation and production of IL-6 and TNF. PMID: 18641647 This ITAM-mediated pathway potently inhibits type I interferon (IFN) and cytokine production by pDCs in response to Toll-like receptor (TLR) activation. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL-6.

Go back
230.0, 778.0
27.0, 27.0

p11

p11

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e30 MO000042007

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c29 : 1
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m30*m19823*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.

Go back
575.0, 883.0
25.0, 25.0

p110

p110

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e121 MO000016573

e131

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c310 : 1
stoichiometry:c320 : 1
stoichiometry:c319 : 1

m123*m1572*0.1

nodelay

--

true

0

false

PMID: 18641647, 15591070, 15815647, 16864658 Conversely, liposome or particle encapsidation of B-type CpG ODNs allows their retention in early endosomes and the subsequent induction of much higher levels of type I IFNs and lower levels of IL-6 and TNF and impaired pDC maturation, which supports the important link between the physical size of TLR9 ligands and their stimulatory capacity.

Go back
1075.0, 1075.0
25.0, 25.0

p111

p111

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e124

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c322 : 1
stoichiometry:c324 : 1
stoichiometry:c323 : 1

m16910*m126*0.1

nodelay

--

true

0

false

PMID: 18641647 Interestingly, when A-type CpG ODNs are disrupted into monomeric structures, they fail to be retained in the early endosome and to induce high amounts of type I IFN production, but instead rapidly traffic to late endosomes and induce maturation and production of IL-6 and TNF.

Go back
1140.0, 796.0
23.0, 23.0

p112

p112

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e130

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c325 : 1
stoichiometry:c327 : 1
stoichiometry:c326 : 1

m979*m132*0.1

nodelay

--

true

0

false

PMID: 18641647 This presumably activates a different set of signal mediators, particularly NF-kappaB (nuclear factor-kappaB) and probably MAPKs (mitogen-activated protein kinases) and IRF5, and thereby leads to distinct outcomes of pDC activation without high levels of IFN production.

Go back
517.0, 869.0
25.0, 25.0

p113

p113

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e138

e139

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c333 : 1
stoichiometry:c334 : 1
stoichiometry:c335 : 1

m1572*m140*0.1

nodelay

--

true

0

false

PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
658.0, 1038.0
27.0, 27.0

p114

p114

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e123 e139

e124

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c336 : 1
stoichiometry:c338 : 1
stoichiometry:c337 : 1

m125*m141*0.1

nodelay

--

true

0

false

PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
238.0, 1210.0
27.0, 27.0

p115

p115

cso30:i:ME_Translocation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e135

e140

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c289 : 1
stoichiometry:c339 : 1

m137*0.1

nodelay

--

true

0

false

PMID: 18641647 After internalization, the self-DNA?LL37?HMGB1 complex associates with TLR9 in early endosomes by engaging RAGE.

Go back
107.0, 1127.0
25.0, 25.0

p116

p116

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e141 e135

e142

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c341 : 1
stoichiometry:c342 : 1
stoichiometry:c343 : 1

m143*m137*0.1

nodelay

--

true

0

false

PMID: 18641647 DNA-specific IgG antibodies can bind self-DNA?LL37?HMGB1 complexes and potently enhance the internalization of the complex through FcgammaRIIA.

Go back
158.0, 1050.0
27.0, 27.0

p117

p117

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e142 e143

e144

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c344 : 1
stoichiometry:c345 : 1
stoichiometry:c346 : 1

m144*m145*0.1

nodelay

--

true

0

false

PMID: 18641647 DNA-specific IgG antibodies can bind self-DNA?LL37?HMGB1 complexes and potently enhance the internalization of the complex through FcgammaRIIA.

Go back
275.0, 979.0
25.0, 25.0

p118

p118

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e144 MO000042012

e145 e143

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c347 : 1
stoichiometry:c348 : 1
stoichiometry:c349 : 1
stoichiometry:c350 : 1

m146*m19828*0.1

nodelay

--

true

0

false

--

Go back
570.0, 1866.0
27.0, 27.0

p119

p119

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000016658

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c351 : 1

m1634*0.1

nodelay

--

true

0

false

PMID: 18641647, 11711679 The ongoing production of type I IFNs by pDCs in these patients induces an unabated activation and maturation of mDCs that stimulate autoreactive T cells.

Go back
220.0, 633.0
27.0, 27.0

p12

p12

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042126 e33

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m19940*m33*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.

Go back
598.0, 1834.0
27.0, 27.0

p120

p120

cso30:i:CE_CellDifferentiation

cso30:i:CC_Extracellular

--

MO000016658 MO000007384

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c352 : 1
stoichiometry:c353 : 1

m1634*m871*0.1

nodelay

--

true

0

false

PMID: 18641647, 12932356 Furthermore, pDC-derived type I IFNs, together with IL-6, stimulate the differentiation of autoreactive B cells into autoantibody-secreting plasma cells.

Go back
219.0, 415.0
25.0, 25.0

p121

p121

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042126 e146 e148

e147

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c354 : 1
stoichiometry:c355 : 1
stoichiometry:c360 : 1
stoichiometry:c356 : 1

m19940*m148*m150*0.1

nodelay

--

true

0

false

PMID: 18641647, 16330816 However, self-RNA molecules, in particular those rich in uridine or uridine and guanosine (U/UGRNA) and those in small nuclear ribonucleoprotein (snRNP), were shown to trigger pDCs to produce type I IFNs through TLR7 when delivered to endosomes by autoantibodies or liposomes.

Go back
591.0, 1487.0
25.0, 25.0

p122

p122

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e103 e147 e164 e180

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c357 : 1
stoichiometry:c359 : 1
stoichiometry:c391 : 1
stoichiometry:c443 : 1
stoichiometry:c358 : 1

m105*m149*0.1

nodelay

--

true

0

false

PMID: 18641647, 16330816 However, self-RNA molecules, in particular those rich in uridine or uridine and guanosine (U/UGRNA) and those in small nuclear ribonucleoprotein (snRNP), were shown to trigger pDCs to produce type I IFNs through TLR7 when delivered to endosomes by autoantibodies or liposomes. PMID: 18641647 This ITAM-mediated pathway potently inhibits type I interferon (IFN) and cytokine production by pDCs in response to Toll-like receptor (TLR) activation. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL?6.

Go back
143.0, 1651.0
25.0, 25.0

p123

p123

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e149 e152

e151

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c362 : 1
stoichiometry:c363 : 1
stoichiometry:c361 : 1

m151*m154*0.1

nodelay

--

true

0

false

PMID: 18641647, 16735691, 17850179 Both BDCA2 and ILT7 associate with the ¦Ã?chain of the highaffinity Fc receptor for IgE (FcepsilonRIgamma) and activate pDCs through an immunoreceptor-based tyrosine activation motif (ITAM)-mediated signalling pathway.

Go back
164.0, 1828.0
23.0, 23.0

p124

p124

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e150 e152

e153

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c364 : 1
stoichiometry:c365 : 1
stoichiometry:c366 : 1

m152*m154*0.1

nodelay

--

true

0

false

PMID: 18641647, 16735691, 17850179 Both BDCA2 and ILT7 associate with the ¦Ã?chain of the highaffinity Fc receptor for IgE (FcepsilonRIgamma) and activate pDCs through an immunoreceptor-based tyrosine activation motif (ITAM)-mediated signalling pathway.

Go back
405.0, 1825.0
22.0, 22.0

p125

p125

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e155 e154

e157

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c367 : 1
stoichiometry:c368 : 1
stoichiometry:c369 : 1

m157*m156*0.1

nodelay

--

true

0

false

PMID: 18641647, 15941912 Crosslinking of NKp44, a receptor that signals through the ITAM-bearing adaptor DAP12, inhibits IFNalpha production induced by CpG ODNs.

Go back
491.0, 1815.0
25.0, 25.0

p126

p126

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e154 e156

e158

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c370 : 1
stoichiometry:c371 : 1
stoichiometry:c372 : 1

m156*m158*0.1

nodelay

--

true

0

false

PMID: 18641647, 16293595 In mice, antibody crosslinking of Siglec-H (sialicacid-binding immunoglobulin-like lectin H), another DAP12-associated receptor expressed by pDCs, reduces type I IFN production by pDCs in vitro and in vivo.

Go back
319.0, 1599.0
25.0, 25.0

p127

p127

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e159 e151

e160

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c373 : 1
stoichiometry:c381 : 1
stoichiometry:c374 : 1

m161*m153*0.1

nodelay

--

true

0

false

PMID: 18641647 These receptor complexes or receptors with intrinsic ITAMs, such as FcgammaRIIA, signal through their ITAMs and activate a B-cell receptor (BCR)-like pathway that involves SRC family protein tyrosine kinases (PTKs), SYK (spleen tyrosine kinase) and the B-cell-specific adaptors BLNK (B-cell linker) and BCAP (B-cell adaptor protein).

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322.0, 1646.0
27.0, 27.0

p128

p128

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e159 e153

e160

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c375 : 1
stoichiometry:c382 : 1
stoichiometry:c376 : 1

m161*m155*0.1

nodelay

--

true

0

false

PMID: 18641647 These receptor complexes or receptors with intrinsic ITAMs, such as FcgammaRIIA, signal through their ITAMs and activate a B-cell receptor (BCR)-like pathway that involves SRC family protein tyrosine kinases (PTKs), SYK (spleen tyrosine kinase) and the B-cell-specific adaptors BLNK (B-cell linker) and BCAP (B-cell adaptor protein).

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423.0, 1599.0
25.0, 25.0

p129

p129

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e159 e158

e160

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c377 : 1
stoichiometry:c383 : 1
stoichiometry:c378 : 1

m161*m160*0.1

nodelay

--

true

0

false

PMID: 18641647 These receptor complexes or receptors with intrinsic ITAMs, such as FcgammaRIIA, signal through their ITAMs and activate a B-cell receptor (BCR)-like pathway that involves SRC family protein tyrosine kinases (PTKs), SYK (spleen tyrosine kinase) and the B-cell-specific adaptors BLNK (B-cell linker) and BCAP (B-cell adaptor protein).

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231.0, 823.0
25.0, 25.0

p13

p13

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042007 e33

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c35 : 1
stoichiometry:c36 : 1
stoichiometry:c39 : 1

m19823*m33*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.

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422.0, 1646.0
27.0, 27.0

p130

p130

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e159 e157

e160

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c379 : 1
stoichiometry:c384 : 1
stoichiometry:c380 : 1

m161*m159*0.1

nodelay

--

true

0

false

PMID: 18641647 These receptor complexes or receptors with intrinsic ITAMs, such as FcgammaRIIA, signal through their ITAMs and activate a B-cell receptor (BCR)-like pathway that involves SRC family protein tyrosine kinases (PTKs), SYK (spleen tyrosine kinase) and the B-cell-specific adaptors BLNK (B-cell linker) and BCAP (B-cell adaptor protein).

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466.0, 1590.0
27.0, 27.0

p131

p131

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e162 e160

e161

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c385 : 1
stoichiometry:c387 : 1
stoichiometry:c386 : 1

m164*m162*0.1

nodelay

--

true

0

false

PMID: 18641647 These receptor complexes or receptors with intrinsic ITAMs, such as FcgammaRIIA, signal through their ITAMs and activate a B-cell receptor (BCR)-like pathway that involves SRC family protein tyrosine kinases (PTKs), SYK (spleen tyrosine kinase) and the B-cell-specific adaptors BLNK (B-cell linker) and BCAP (B-cell adaptor protein).

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515.0, 1527.0
25.0, 25.0

p132

p132

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e163 e161

e164

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c388 : 1
stoichiometry:c390 : 1
stoichiometry:c389 : 1

m165*m163*0.1

nodelay

--

true

0

false

PMID: 18641647 These receptor complexes or receptors with intrinsic ITAMs, such as FcgammaRIIA, signal through their ITAMs and activate a B-cell receptor (BCR)-like pathway that involves SRC family protein tyrosine kinases (PTKs), SYK (spleen tyrosine kinase) and the B-cell-specific adaptors BLNK (B-cell linker) and BCAP (B-cell adaptor protein).

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319.0, 1547.0
25.0, 25.0

p133

p133

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e165 e159

e160

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c398 : 1
stoichiometry:c399 : 1
stoichiometry:c400 : 1

m167*m161*0.1

nodelay

--

true

0

false

PMID: 18641647 These receptor complexes or receptors with intrinsic ITAMs, such as FcgammaRIIA, signal through their ITAMs and activate a B-cell receptor (BCR)-like pathway that involves SRC family protein tyrosine kinases (PTKs), SYK (spleen tyrosine kinase) and the B-cell-specific adaptors BLNK (B-cell linker) and BCAP (B-cell adaptor protein).

Go back
742.0, 1682.0
27.0, 27.0

p134

p134

cso30:i:ME_Binding

cso30:i:CC_Cytoplasm

--

e167 e166

e168

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c401 : 1
stoichiometry:c402 : 1
stoichiometry:c403 : 1

m169*m168*0.1

nodelay

--

true

0

false

PMID: 18641647 However, PDC-TREM (triggering receptor expressed on myeloid cells), a newly discovered pDC-specific transmembrane receptor that forms a complex with plexin A1, is activated by its endogenous ligand semaphorin 6D to induce DAP12-mediated activation of PI3K and extracellular-signal-regulated kinase 1 (ERK1) and ERK2, which leads to enhanced levels of type I IFN production.

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691.0, 1687.0
25.0, 25.0

p135

p135

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e168 e154 MO000000030

e169

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c404 : 1
stoichiometry:c405 : 1
stoichiometry:c407 : 1
stoichiometry:c406 : 1

m170*m156*m72*0.1

nodelay

--

true

0

false

PMID: 18641647 However, PDC-TREM (triggering receptor expressed on myeloid cells), a newly discovered pDC-specific transmembrane receptor that forms a complex with plexin A1, is activated by its endogenous ligand semaphorin 6D to induce DAP12-mediated activation of PI3K and extracellular-signal-regulated kinase 1 (ERK1) and ERK2, which leads to enhanced levels of type I IFN production.

Go back
675.0, 1595.0
25.0, 25.0

p136

p136

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e170 e168 e154

e172

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c408 : 1
stoichiometry:c412 : 1
stoichiometry:c414 : 1
stoichiometry:c409 : 1

m172*m170*m156*0.1

nodelay

--

true

0

false

PMID: 18641647 However, PDC-TREM (triggering receptor expressed on myeloid cells), a newly discovered pDC-specific transmembrane receptor that forms a complex with plexin A1, is activated by its endogenous ligand semaphorin 6D to induce DAP12-mediated activation of PI3K and extracellular-signal-regulated kinase 1 (ERK1) and ERK2, which leads to enhanced levels of type I IFN production.

Go back
688.0, 1652.0
23.0, 23.0

p137

p137

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytoplasm

--

e171 e168 e154

e173

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c410 : 1
stoichiometry:c413 : 1
stoichiometry:c415 : 1
stoichiometry:c411 : 1

m173*m170*m156*0.1

nodelay

--

true

0

false

PMID: 18641647 However, PDC-TREM (triggering receptor expressed on myeloid cells), a newly discovered pDC-specific transmembrane receptor that forms a complex with plexin A1, is activated by its endogenous ligand semaphorin 6D to induce DAP12-mediated activation of PI3K and extracellular-signal-regulated kinase 1 (ERK1) and ERK2, which leads to enhanced levels of type I IFN production.

Go back
696.0, 1432.0
23.0, 23.0

p138

p138

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e103 e172 e173 e169

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c417 : 1
stoichiometry:c418 : 1
stoichiometry:c419 : 1
stoichiometry:c420 : 1
stoichiometry:c416 : 1

m105*m174*m175*m171*0.1

nodelay

--

true

0

false

PMID: 18641647 However, PDC-TREM (triggering receptor expressed on myeloid cells), a newly discovered pDC-specific transmembrane receptor that forms a complex with plexin A1, is activated by its endogenous ligand semaphorin 6D to induce DAP12-mediated activation of PI3K and extracellular-signal-regulated kinase 1 (ERK1) and ERK2, which leads to enhanced levels of type I IFN production.

Go back
893.0, 1777.0
27.0, 27.0

p139

p139

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

e174 e175

e166

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c421 : 1
stoichiometry:c422 : 1
stoichiometry:c423 : 1

m176*m177*0.1

nodelay

--

true

0

false

PMID: 18641647 However, PDC-TREM (triggering receptor expressed on myeloid cells), a newly discovered pDC-specific transmembrane receptor that forms a complex with plexin A1, is activated by its endogenous ligand semaphorin 6D to induce DAP12-mediated activation of PI3K and extracellular-signal-regulated kinase 1 (ERK1) and ERK2, which leads to enhanced levels of type I IFN production.

Go back
231.0, 859.0
25.0, 25.0

p14

p14

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e20 MO000042012

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c20 : 1
stoichiometry:c41 : 1
stoichiometry:c42 : 1

m20*m19828*0.1

nodelay

--

true

0

false

PMID: 18641647, 17572678 Synthetic ODNs containing CpG dinucleotides can interact directly with the ectodomain of TLR9 and induce conformational changes40 that lead to downstream signalling activation.

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163.0, 1399.0
25.0, 25.0

p140

p140

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e177 e178

e176

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c425 : 1
stoichiometry:c426 : 1
stoichiometry:c427 : 1

m179*m180*0.1

nodelay

--

true

0

false

PMID: 18641647, 17993619 The nucleotides that bind to P2Y receptors are also known to be released and to accumulate at sites of cell stress and tissue damage.

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204.0, 1316.0
23.0, 23.0

p141

p141

cso30:i:ME_UnknownActivation

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e179 e181

e180

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c428 : 1
stoichiometry:c430 : 1
stoichiometry:c429 : 1

m182*m186*0.1

nodelay

--

true

0

false

PMID: 18641647, 16330816, 16260486 These self-RNA and autoantibody complexes were also shown to activate autoreactive B cells through the B-cell receptor (BCR) and endosomal TLR7.

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132.0, 488.0
23.0, 23.0

p142

p142

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000042126 e181

e182

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c431 : 1
stoichiometry:c433 : 1
stoichiometry:c432 : 1

m19940*m186*0.1

nodelay

--

true

0

false

PMID: 18641647, 16330816, 16260486 These self-RNA and autoantibody complexes were also shown to activate autoreactive B cells through the B-cell receptor (BCR) and endosomal TLR7.

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801.0, 1201.0
25.0, 25.0

p143

p143

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e183 e45

e184

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c445 : 1
stoichiometry:c446 : 1
stoichiometry:c444 : 1

m188*m45*0.1

nodelay

--

true

0

false

PMID: 18641647, 11160284 By contrast, myeloid DCs (mDCs) produced type I IFNs and interleukin?12 (IL-12) in response to polyI:C but not to CpG-containing DNA.

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154.0, 930.0
27.0, 27.0

p144

p144

cso30:i:CE_CellProliferation

cso30:i:CC_Extracellular

--

e131

--

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c447 : 1

m133*0.1

nodelay

--

true

0

false

--

Go back
788.0, 1232.0
23.0, 23.0

p145

p145

cso30:i:ME_Translation

cso30:i:CC_Nucleoplasm

--

e186 e122

e185

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c448 : 1
stoichiometry:c450 : 1
stoichiometry:c449 : 1

m191*m124*0.1

nodelay

--

true

0

false

PMID: 18641647, 11160295, 14971051 Interestingly, at the same time, Klinman and colleagues classified CpG ODNs into two main groups: D-type (now known as A-type) CpG ODNs, which stimulate IFNgamma production by natural killer (NK) cells, and K-type (now known as B-type) CpG ODNs, which stimulate B-cell proliferation and B-cell IL-6 and antibody production.

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742.0, 1254.0
27.0, 27.0

p146

p146

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

e188 e131

e187

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c451 : 1
stoichiometry:c453 : 1
stoichiometry:c452 : 1

m193*m133*0.1

nodelay

--

true

0

false

PMID: 18641647, 11160295, 14971051 Interestingly, at the same time, Klinman and colleagues classified CpG ODNs into two main groups: D-type (now known as A-type) CpG ODNs, which stimulate IFNgamma production by natural killer (NK) cells, and K-type (now known as B-type) CpG ODNs, which stimulate B-cell proliferation and B-cell IL-6 and antibody production.

Go back
1077.0, 221.0
25.0, 25.0

p15

p15

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000068831

e38

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c43 : 1
stoichiometry:c45 : 1
stoichiometry:c44 : 1

m14*m43675*0.1

nodelay

--

true

0

false

PMID: 18641647, 15229469, 16675322 TLR4 signals through MyD88, TIRAP, TRIF and TRAM; and TLR2 uses both MyD88 and TIRAP.

Go back
1181.5, 277.0
25.5, 25.5

p16

p16

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 MO000016573

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c48 : 1
stoichiometry:c47 : 1

m43675*m1572*0.1

nodelay

--

true

0

false

PMID: 18641647, 15229469, 16675322 TLR4 signals through MyD88, TIRAP, TRIF and TRAM; and TLR2 uses both MyD88 and TIRAP.

Go back
987.0, 239.0
26.0, 26.0

p17

p17

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e14 MO000041132

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c49 : 1
stoichiometry:c50 : 1
stoichiometry:c51 : 1

m14*m19005*0.1

nodelay

--

true

0

false

PMID: 18641647, 15229469, 16675322 TLR4 signals through MyD88, TIRAP, TRIF and TRAM; and TLR2 uses both MyD88 and TIRAP.

Go back
947.0, 226.0
25.0, 25.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e40 MO000041125

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c52 : 1
stoichiometry:c53 : 1
stoichiometry:c54 : 1

m40*m18998*0.1

nodelay

--

true

0

false

PMID: 18641647, 15229469, 16675322 TLR4 signals through MyD88, TIRAP, TRIF and TRAM; and TLR2 uses both MyD88 and TIRAP.

Go back
1159.0, 403.0
25.0, 25.0

p19

p19

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000068831 e19

e42

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c55 : 1
stoichiometry:c56 : 1
stoichiometry:c57 : 1

m43675*m19*0.1

nodelay

--

true

0

false

PMID: 18641647, 15229469, 16675322 TLR4 signals through MyD88, TIRAP, TRIF and TRAM; and TLR2 uses both MyD88 and TIRAP.

Go back
1385.0, 1714.0
22.0, 22.0

p2

p2

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e13 e16

e15

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m13*m16*0.1

nodelay

--

true

0

false

PMID: 18641647, 9237759, 11323673, 10364168 The leucine-rich repeats of the TLR ectodomains bind to pathogen-associated molecular patterns (PAMPs), such as the bacterial cell-wall component lipopolysaccharide (a ligand of TLR4), bacterial flagellin (a ligand of TLR5), and lipoprotein and peptidoglycan (which are recognized by TLR2 complexed with TLR1 or TLR6).

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1162.0, 462.0
27.0, 27.0

p20

p20

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e42 MO000016573

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c58 : 1
stoichiometry:c60 : 1
stoichiometry:c59 : 1

m42*m1572*0.1

nodelay

--

true

0

false

PMID: 18641647, 15229469, 16675322 TLR4 signals through MyD88, TIRAP, TRIF and TRAM; and TLR2 uses both MyD88 and TIRAP.

Go back
281.0, 375.0
25.0, 25.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000019398 e45

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c62 : 1
stoichiometry:c63 : 1

m3965*m45*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR3, which is localized in endosomes, recognizes viral dsRNA and its synthetic mimic polyI:C.

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444.0, 376.0
23.0, 23.0

p22

p22

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c64 : 1
stoichiometry:c65 : 1
stoichiometry:c66 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR3, which is localized in endosomes, recognizes viral dsRNA and its synthetic mimic polyI:C.

Go back
511.0, 319.0
26.0, 26.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041446 MO000041125

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c67 : 1
stoichiometry:c68 : 1
stoichiometry:c69 : 1

m19314*m18998*0.1

nodelay

--

true

0

false

PMID: 18641647, 12471095, 12855817 Indeed, TLR3 was shown to associate with TRIF and signal through IRF3, a key factor involved in IFNbeta production.

Go back
551.0, 415.0
25.0, 25.0

p24

p24

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e24

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c70 : 1
stoichiometry:c73 : 1
stoichiometry:c74 : 1

m1572*m24*0.1

nodelay

--

true

0

false

PMID: 18641647 Endosomal Toll-like receptor 7 (TLR7), TLR8 and TLR9 recognize RNA and DNA ligands, and signal through a key adaptor MyD88 (myeloid differentiation primary-response gene 88) in the cytosol.

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639.0, 703.0
25.0, 25.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000016573 e25

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c71 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m1572*m25*0.1

nodelay

--

true

0

false

PMID: 18641647 Endosomal Toll-like receptor 7 (TLR7), TLR8 and TLR9 recognize RNA and DNA ligands, and signal through a key adaptor MyD88 (myeloid differentiation primary-response gene 88) in the cytosol.

Go back
658.0, 826.0
27.0, 27.0

p26

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016573 e26

e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c77 : 1
stoichiometry:c78 : 1

m1572*m26*0.1

nodelay

--

true

0

false

PMID: 18641647 Endosomal Toll-like receptor 7 (TLR7), TLR8 and TLR9 recognize RNA and DNA ligands, and signal through a key adaptor MyD88 (myeloid differentiation primary-response gene 88) in the cytosol.

Go back
803.0, 463.0
25.0, 25.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 MO000039077 MO000001935 MO000000212

e46 e49

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c79 : 1
stoichiometry:c80 : 1
stoichiometry:c94 : 1
stoichiometry:c81 : 1
stoichiometry:c88 : 1
stoichiometry:c91 : 1

m184*m17258*m367*m183*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NF?kappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases).

Go back
823.0, 679.0
25.0, 25.0

p28

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 MO000039077 MO000000212 MO000001935

e47 e63

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c82 : 1
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c95 : 1
stoichiometry:c89 : 1
stoichiometry:c92 : 1

m184*m17258*m183*m367*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NF?kappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases).

Go back
810.0, 826.0
27.0, 27.0

p29

p29

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000000213 MO000039077 MO000000212 MO000001935

e48 e64

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c85 : 1
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c96 : 1
stoichiometry:c90 : 1
stoichiometry:c93 : 1

m184*m17258*m183*m367*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NF?kappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases).

Go back
1423.0, 255.0
25.0, 25.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e17 e18

e19

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c9 : 1

m17*m18*0.1

nodelay

--

true

0

false

PMID: 18641647, 9237759, 11323673, 10364168 The leucine-rich repeats of the TLR ectodomains bind to pathogen-associated molecular patterns (PAMPs), such as the bacterial cell-wall component lipopolysaccharide (a ligand of TLR4), bacterial flagellin (a ligand of TLR5), and lipoprotein and peptidoglycan (which are recognized by TLR2 complexed with TLR1 or TLR6).

Go back
1015.0, 1011.0
25.0, 25.0

p30

p30

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e68

MO000041457 MO000019331 MO000000210 MO000016963 MO000061307 MO000000213

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1
stoichiometry:c124 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1

m68*0.1

nodelay

--

true

0

false

PMID: 18641647 Most importantly, IRF7 is activated through TRAF3, IRAK1, IKKalpha (inhibitor of NF-kappaB kinase alpha), osteopontin (OPN) and phosphoinositide 3-kinase (PI3K). PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NF?kappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases). PMID: 18641647, 15361868 IRF7 is activated through ubiquitylation by the ubiquitin E3 ligase activity of TRAF6 (ref. 86) and phosphorylation by IRAK4.

Go back
815.0, 867.0
25.0, 25.0

p31

p31

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e64

e72 e48

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c100 : 1
stoichiometry:c101 : 1
stoichiometry:c104 : 1

m64*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin-1- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NFkappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases).

Go back
1019.5, 841.0
26.5, 26.5

p32

p32

cso30:i:ME_Dissociation

cso30:i:CC_Cytosol

--

e67

e69 e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1
stoichiometry:c113 : 1

m67*0.1

nodelay

--

true

0

false

PMID: 18641647 The MyD88?TRAF6?IRAK4 complex then activates IRF7 (interferon-regulatory factor 7), TAK1 (transforming?growth-factor-beta-activated kinase 1), nuclear factor-kappaB (NF-kappaB) and IRF5 to propagate the downstream signals.

Go back
1207.0, 1027.0
25.0, 25.0

p33

p33

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 e71

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c106 : 1
stoichiometry:c134 : 1
stoichiometry:c107 : 1

m16910*m74*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NF?kappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases). PMID: 18641647 The MyD88?TRAF6?IRAK4 complex then activates IRF7 (interferon-regulatory factor 7), TAK1 (transforming?growth-factor-beta-activated kinase 1), nuclear factor-kappaB (NF-kappaB) and IRF5 to propagate the downstream signals. PMID: 18641647 TAK1 triggers the activation of NF?kappaB and MAPKs (mitogen-activated protein kinases) and, together with IRF5, leads to the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules. PMID: 18641647 This presumably activates a different set of signal mediators, particularly NF-kappaB (nuclear factor-kappaB) and probably MAPKs (mitogen-activated protein kinases) and IRF5, and thereby leads to distinct outcomes of pDC activation without high levels of IFN production.

Go back
959.0, 919.0
25.0, 25.0

p34

p34

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019331 MO000000210 MO000016963 e69 MO000061307 MO000000030

e68

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c114 : 1
stoichiometry:c117 : 1
stoichiometry:c118 : 1
stoichiometry:c119 : 1
stoichiometry:c121 : 1
stoichiometry:c129 : 1
stoichiometry:c120 : 1

m3902*m181*m1872*m70*m36205*m72*0.1

nodelay

--

true

0

false

PMID: 18641647 Most importantly, IRF7 is activated through TRAF3, IRAK1, IKKalpha (inhibitor of NF-kappaB kinase alpha), osteopontin (OPN) and phosphoinositide 3-kinase (PI3K).

Go back
1139.0, 847.0
25.0, 25.0

p35

p35

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016574 e70

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c130 : 1
stoichiometry:c132 : 1
stoichiometry:c131 : 1

m1573*m71*0.1

nodelay

--

true

0

false

PMID: 18641647 The MyD88?TRAF6?IRAK4 complex then activates IRF7 (interferon-regulatory factor 7), TAK1 (transforming?growth-factor-beta-activated kinase 1), nuclear factor-kappaB (NF-kappaB) and IRF5 to propagate the downstream signals.

Go back
1136.0, 930.0
27.0, 27.0

p36

p36

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 e71

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c133 : 1
stoichiometry:c116 : 1

m69*m74*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NF?kappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases). PMID: 18641647 TAK1 triggers the activation of NF?kappaB and MAPKs (mitogen-activated protein kinases) and, together with IRF5, leads to the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules. PMID: 18641647 This presumably activates a different set of signal mediators, particularly NF-kappaB (nuclear factor-kappaB) and probably MAPKs (mitogen-activated protein kinases) and IRF5, and thereby leads to distinct outcomes of pDC activation without high levels of IFN production.

Go back
1203.0, 1123.0
25.0, 25.0

p37

p37

cso30:i:ME_ProteasomeDegradation

cso30:i:CC_Cytosol

--

MO000000254

MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m208*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NF?kappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases). PMID: 18641647 TAK1 triggers the activation of NF?kappaB and MAPKs (mitogen-activated protein kinases) and, together with IRF5, leads to the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules. PMID: 18641647 The TLR3?TRIF signalling pathway also activates NF?kappaB and MAPKs and results in the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules (CD80 and CD86). PMID: 18641647 Interestingly, when A-type CpG ODNs are disrupted into monomeric structures, they fail to be retained in the early endosome and to induce high amounts of type I IFN production, but instead rapidly traffic to late endosomes and induce maturation and production of IL-6 and TNF. PMID: 18641647 This presumably activates a different set of signal mediators, particularly NF-kappaB (nuclear factor-kappaB) and probably MAPKs (mitogen-activated protein kinases) and IRF5, and thereby leads to distinct outcomes of pDC activation without high levels of IFN production.

Go back
1017.0, 1281.0
25.0, 25.0

p38

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

G016992

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c144 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18641647 Following ubiquitylation and phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I interferons (such as IFNalpha, IFNbeta, IFNlambda and IFNomega). PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
1020.0, 632.0
23.0, 23.0

p39

p39

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000007702 e72

e66

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c98 : 1
stoichiometry:c105 : 1
stoichiometry:c108 : 1

m980*m73*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin-1- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NFkappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases).

Go back
1426.0, 350.0
27.0, 27.0

p4

p4

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e21 MO000042032

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1

m21*m155701*0.1

nodelay

--

true

0

false

PMID: 18641647, 9237759, 11323673, 10364168 The leucine-rich repeats of the TLR ectodomains bind to pathogen-associated molecular patterns (PAMPs), such as the bacterial cell-wall component lipopolysaccharide (a ligand of TLR4), bacterial flagellin (a ligand of TLR5), and lipoprotein and peptidoglycan (which are recognized by TLR2 complexed with TLR1 or TLR6).

Go back
1139.0, 747.0
25.0, 25.0

p40

p40

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000007700 e70

e73

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c141 : 1
stoichiometry:c138 : 1

m979*m71*0.1

nodelay

--

true

0

false

PMID: 18641647 The MyD88?TRAF6?IRAK4 complex then activates IRF7 (interferon-regulatory factor 7), TAK1 (transforming?growth-factor-beta-activated kinase 1), nuclear factor-kappaB (NF-kappaB) and IRF5 to propagate the downstream signals.

Go back
987.0, 1183.0
25.0, 25.0

p41

p41

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000041457

e74

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 18641647 Following ubiquitylation and phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I interferons (such as IFNalpha, IFNbeta, IFNlambda and IFNomega). PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
1075.0, 687.0
25.0, 25.0

p42

p42

cso30:i:ME_Ubiquitination

cso30:i:CC_Cytosol

--

e66

e67

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c109 : 1
stoichiometry:c110 : 1

m66*0.1

nodelay

--

true

0

false

PMID: 18641647, 15361868 IRF7 is activated through ubiquitylation by the ubiquitin E3 ligase activity of TRAF6 (ref. 86) and phosphorylation by IRAK4.

Go back
1020.0, 1344.0
24.0, 24.0

p43

p43

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c149 : 1
stoichiometry:c145 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18641647 Following ubiquitylation and phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I interferons (such as IFNalpha, IFNbeta, IFNlambda and IFNomega). PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
985.0, 1409.0
21.0, 21.0

p44

p44

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c150 : 1
stoichiometry:c147 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18641647 Following ubiquitylation and phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I interferons (such as IFNalpha, IFNbeta, IFNlambda and IFNomega). PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
949.0, 489.0
29.0, 29.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e49

e72 e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c102 : 1

m49*0.1

nodelay

--

true

0

false

Go back
899.0, 775.0
25.0, 25.0

p46

p46

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e63

e72 e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c99 : 1
stoichiometry:c103 : 1

m63*0.1

nodelay

--

true

0

false

PMID: 18641647 MyD88 in turn associates with a signal complex comprised of TRAF6 (tumour-necrosis factor (TNF)-receptor-associated factor 6), BTK (Bruton¡Çs tyrosine kinase), IRAK4 (interleukin-1- receptor (IL-1R)-associated kinase 4) and IRAK1, which leads to the activation of IRF7 (interferon-regulatory factor 7), NFkappaB (nuclear factorkappaB) and MAPKs (mitogen-activated protein kinases).

Go back
969.0, 1457.0
22.0, 22.0

p47

p47

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e74

G012384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c146 : 1

m76*0.1

nodelay

--

true

0

false

PMID: 18641647 Following ubiquitylation and phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I interferons (such as IFNalpha, IFNbeta, IFNlambda and IFNomega). PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 Aggregated self-DNA?LL37 complexes are retained in the early endosomes of pDCs, and, similar to A-type CpG ODNs, they trigger the TLR9?MyD88?IRF7 pathway of type I IFN production without inducing pDC maturation.

Go back
1126.0, 1210.0
27.0, 27.0

p48

p48

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016632

e77

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m1617*0.1

nodelay

--

true

0

false

PMID: 18641647 TAK1 triggers the activation of NF?kappaB and MAPKs (mitogen-activated protein kinases) and, together with IRF5, leads to the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules. PMID: 18641647 Interestingly, when A-type CpG ODNs are disrupted into monomeric structures, they fail to be retained in the early endosome and to induce high amounts of type I IFN production, but instead rapidly traffic to late endosomes and induce maturation and production of IL-6 and TNF. PMID: 18641647 This presumably activates a different set of signal mediators, particularly NF-kappaB (nuclear factor-kappaB) and probably MAPKs (mitogen-activated protein kinases) and IRF5, and thereby leads to distinct outcomes of pDC activation without high levels of IFN production.

Go back
1095.0, 1379.0
25.0, 25.0

p49

p49

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c156 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 18641647 Overall, this pathway potently induces the production of high levels of type I IFNs (such as IFNalpha, IFNbeta, IFNlambda and IFNomega), pro-inflammatory cytokines and expression of co-stimulatory molecules. PMID: 18641647 Interestingly, when A-type CpG ODNs are disrupted into monomeric structures, they fail to be retained in the early endosome and to induce high amounts of type I IFN production, but instead rapidly traffic to late endosomes and induce maturation and production of IL-6 and TNF. PMID: 18641647, 11160284, 11561001, 7700380 On the other hand, B-type CpG ODNs can activate B cells but only trigger pDCs to produce the pro-inflammatory cytokines TNF and IL-6, and small amounts of IFN, as well as inducing the upregulation of CD80, CD86 and the expression of MHC class II molecules.

Go back
443.0, 515.0
25.0, 25.0

p5

p5

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e23

e24

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m19940*m23*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.PMID: 18641647

Go back
1143.0, 1423.0
25.0, 25.0

p50

p50

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e77

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c155 : 1
stoichiometry:c157 : 1

m79*0.1

nodelay

--

true

0

false

PMID: 18641647 Overall, this pathway potently induces the production of high levels of type I IFNs (such as IFNalpha, IFNbeta, IFNlambda and IFNomega), pro-inflammatory cytokines and expression of co-stimulatory molecules. PMID: 18641647 Interestingly, when A-type CpG ODNs are disrupted into monomeric structures, they fail to be retained in the early endosome and to induce high amounts of type I IFN production, but instead rapidly traffic to late endosomes and induce maturation and production of IL-6 and TNF. PMID: 18641647, 11160284, 11561001, 7700380 On the other hand, B-type CpG ODNs can activate B cells but only trigger pDCs to produce the pro-inflammatory cytokines TNF and IL-6, and small amounts of IFN, as well as inducing the upregulation of CD80, CD86 and the expression of MHC class II molecules.

Go back
1075.0, 1511.0
25.0, 25.0

p51

p51

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

G012224

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c158 : 1
stoichiometry:c160 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 18641647 Overall, this pathway potently induces the production of high levels of type I IFNs (such as IFNalpha, IFNbeta, IFNlambda and IFNomega), pro-inflammatory cytokines and expression of co-stimulatory molecules. PMID: 18641647 The TLR3?TRIF signalling pathway also activates NF?kappaB and MAPKs and results in the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules (CD80 and CD86). PMID: 18641647, 11160284, 11561001, 7700380 On the other hand, B-type CpG ODNs can activate B cells but only trigger pDCs to produce the pro-inflammatory cytokines TNF and IL-6, and small amounts of IFN, as well as inducing the upregulation of CD80, CD86 and the expression of MHC class II molecules.

Go back
1051.0, 1587.0
25.0, 25.0

p52

p52

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e65

G010859

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c159 : 1
stoichiometry:c161 : 1

m65*0.1

nodelay

--

true

0

false

PMID: 18641647 Overall, this pathway potently induces the production of high levels of type I IFNs (such as IFNalpha, IFNbeta, IFNlambda and IFNomega), pro-inflammatory cytokines and expression of co-stimulatory molecules. PMID: 18641647 The TLR3?TRIF signalling pathway also activates NF?kappaB and MAPKs and results in the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules (CD80 and CD86). PMID: 18641647, 11160284, 11561001, 7700380 On the other hand, B-type CpG ODNs can activate B cells but only trigger pDCs to produce the pro-inflammatory cytokines TNF and IL-6, and small amounts of IFN, as well as inducing the upregulation of CD80, CD86 and the expression of MHC class II molecules.

Go back
511.0, 1139.0
25.0, 25.0

p53

p53

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000041437 e76

e78

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c162 : 1
stoichiometry:c163 : 1
stoichiometry:c164 : 1

m19305*m78*0.1

nodelay

--

true

0

false

PMID: 18641647 Alternatively, the binding of double-stranded RNA (dsRNA) to endosomal TLR3 triggers a signalling pathway mediated by TRIF (Toll/IL-1R (TIR) domain-containing adaptor protein inducing IFNbeta), which involves TRAF3, TBK1 (TANK-binding kinase 1) and IKKepsilon (inhibitor of NF?kappaB kinase epsilon). PMID: 18641647 By coupling with TRAF3, TBK1 and IKKepsilon, IPS1 directly activates IRF3 and NF?kappaB through FADD (FAS-associated via death domain), caspase?8 and caspase?10.

Go back
592.0, 1196.0
25.0, 25.0

p54

p54

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e78

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c165 : 1
stoichiometry:c167 : 1
stoichiometry:c166 : 1

m977*m80*0.1

nodelay

--

true

0

false

PMID: 18641647 Subsequent IRF3 activation leads to IFNbeta production.

Go back
578.0, 1322.0
27.0, 27.0

p55

p55

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 MO000041456 e176 e180 e164

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c424 : 1
stoichiometry:c435 : 1
stoichiometry:c437 : 1
stoichiometry:c168 : 1

m93217*m19324*0.1

nodelay

--

true

0

false

PMID: 18641647 Subsequent IRF3 activation leads to IFNbeta production. PMID: 18641647, 17993619 Last, P2Y receptors, a family of G-protein-coupled receptors, downregulate IFNalpha secretion by human pDCs following stimulation by nucleotides such as ATP, ADP and UDP-glucose. PMID: 18641647, 17993619 The nucleotides that bind to P2Y receptors are also known to be released and to accumulate at sites of cell stress and tissue damage. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL-6.

Go back
1203.0, 1079.0
25.0, 25.0

p56

p56

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000038724 MO000041437

MO000000254

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c171 : 1
stoichiometry:c173 : 1
stoichiometry:c172 : 1

m16910*m19305*0.1

nodelay

--

true

0

false

PMID: 18641647 The TLR3?TRIF signalling pathway also activates NF?kappaB and MAPKs and results in the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules (CD80 and CD86).

Go back
1134.0, 978.0
27.0, 27.0

p57

p57

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 MO000041437

e65

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c174 : 1
stoichiometry:c176 : 1
stoichiometry:c175 : 1

m69*m19305*0.1

nodelay

--

true

0

false

PMID: 18641647 The TLR3?TRIF signalling pathway also activates NF?kappaB and MAPKs and results in the production of pro-inflammatory cytokines and the expression of co-stimulatory molecules (CD80 and CD86).

Go back
306.0, 174.0
27.0, 27.0

p58

p58

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e79 e80

e81

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c177 : 1
stoichiometry:c178 : 1
stoichiometry:c179 : 1

m81*m82*0.1

nodelay

--

true

0

false

PMID: 18641647 The dsRNA receptors RIG?I (retinoic-acid-inducible gene I), MDA5 (melanoma differentiation-associated gene 5) and LGP2 (laboratory of genetics and physiology 2) constitute the third nucleic-acid sensor system, exclusively located in the cytoplasm of most cells.

Go back
407.0, 215.0
25.0, 25.0

p59

p59

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e80 MO000103999

e82

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c180 : 1
stoichiometry:c181 : 1
stoichiometry:c182 : 1

m82*m76904*0.1

nodelay

--

true

0

false

PMID: 18641647 The dsRNA receptors RIG?I (retinoic-acid-inducible gene I), MDA5 (melanoma differentiation-associated gene 5) and LGP2 (laboratory of genetics and physiology 2) constitute the third nucleic-acid sensor system, exclusively located in the cytoplasm of most cells.

Go back
443.0, 671.0
25.0, 25.0

p6

p6

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042007 e23

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c17 : 1
stoichiometry:c18 : 1

m19823*m23*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.

Go back
543.0, 215.0
26.0, 26.0

p60

p60

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e84 e80

e83

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c183 : 1
stoichiometry:c185 : 1
stoichiometry:c184 : 1

m86*m82*0.1

nodelay

--

true

0

false

PMID: 18641647 The dsRNA receptors RIG?I (retinoic-acid-inducible gene I), MDA5 (melanoma differentiation-associated gene 5) and LGP2 (laboratory of genetics and physiology 2) constitute the third nucleic-acid sensor system, exclusively located in the cytoplasm of most cells.

Go back
694.0, 226.0
27.0, 27.0

p61

p61

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e81

e94

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c186 : 1
stoichiometry:c192 : 1
stoichiometry:c189 : 1

m68199*m83*0.1

nodelay

--

true

0

false

PMID: 18641647 RIGI, MDA5 and LGP2 signal through a common adaptor molecule IPS1 (IFNB-promoter stimulator 1), which is associated with the mitochondria.

Go back
679.0, 255.0
25.0, 25.0

p62

p62

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e82

e95

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c187 : 1
stoichiometry:c193 : 1
stoichiometry:c190 : 1

m68199*m84*0.1

nodelay

--

true

0

false

PMID: 18641647 RIGI, MDA5 and LGP2 signal through a common adaptor molecule IPS1 (IFNB-promoter stimulator 1), which is associated with the mitochondria.

Go back
743.0, 315.0
25.0, 25.0

p63

p63

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000094908 e83

e96

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c188 : 1
stoichiometry:c194 : 1
stoichiometry:c191 : 1

m68199*m85*0.1

nodelay

--

true

0

false

PMID: 18641647 RIGI, MDA5 and LGP2 signal through a common adaptor molecule IPS1 (IFNB-promoter stimulator 1), which is associated with the mitochondria.

Go back
391.0, 1091.0
25.0, 25.0

p64

p64

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e94 e76

e97

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c196 : 1
stoichiometry:c197 : 1
stoichiometry:c195 : 1

m96*m78*0.1

nodelay

--

true

0

false

PMID: 18641647 By coupling with TRAF3, TBK1 and IKKepsilon, IPS1 directly activates IRF3 and NF?kappaB through FADD (FAS-associated via death domain), caspase8 and caspase10.

Go back
391.0, 1267.0
25.0, 25.0

p65

p65

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e97 e98

e99

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c198 : 1
stoichiometry:c199 : 1
stoichiometry:c200 : 1

m99*m100*0.1

nodelay

--

true

0

false

PMID: 18641647 By coupling with TRAF3, TBK1 and IKKepsilon, IPS1 directly activates IRF3 and NF?kappaB through FADD (FAS-associated via death domain), caspase8 and caspase10.

Go back
523.0, 1247.0
27.0, 27.0

p66

p66

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e99 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c201 : 1
stoichiometry:c202 : 1
stoichiometry:c203 : 1

m101*m977*0.1

nodelay

--

true

0

false

PMID: 18641647 By coupling with TRAF3, TBK1 and IKKepsilon, IPS1 directly activates IRF3 and NF?kappaB through FADD (FAS-associated via death domain), caspase8 and caspase10.

Go back
792.0, 228.0
23.0, 23.0

p67

p67

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000061425 e80

e101

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c204 : 1
stoichiometry:c209 : 1
stoichiometry:c205 : 1

m36323*m82*0.1

nodelay

--

true

0

false

PMID: 18641647, 17653195 First, a recently described molecule termed DNA-dependent activator of IRFs (DAI) has been shown in vitro to act as a cytosolic DNA sensor by binding dsDNA and signalling through TBK1 and IRF3 to activate NF-kappaB and induce type I IFN production.

Go back
1075.0, 1159.0
25.0, 25.0

p68

p68

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e99 e100

MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c206 : 1
stoichiometry:c208 : 1
stoichiometry:c207 : 1

m101*m102*0.1

nodelay

--

true

0

false

PMID: 18641647 By coupling with TRAF3, TBK1 and IKKepsilon, IPS1 directly activates IRF3 and NF?kappaB through FADD (FAS-associated via death domain), caspase8 and caspase10.

Go back
782.0, 958.0
27.0, 27.0

p69

p69

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000019331 e101

e102

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c210 : 1
stoichiometry:c212 : 1
stoichiometry:c211 : 1

m3902*m103*0.1

nodelay

--

true

0

false

PMID: 18641647, 17653195 First, a recently described molecule termed DNA-dependent activator of IRFs (DAI) has been shown in vitro to act as a cytosolic DNA sensor by binding dsDNA and signalling through TBK1 and IRF3 to activate NF-kappaB and induce type I IFN production.

Go back
407.0, 859.0
25.0, 25.0

p7

p7

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

MO000042012 e36

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c40 : 1
stoichiometry:c21 : 1

m19828*m36*0.1

nodelay

--

true

0

false

PMID: 18641647, 11130078, 11470918 TLR9 seems to detect ssDNA molecules that contain unmethylated CpG-containing motifs, which are commonly found in the genomes of viruses and bacteria.

Go back
636.0, 1180.0
25.0, 25.0

p70

p70

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000007694 e102

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c213 : 1
stoichiometry:c215 : 1
stoichiometry:c214 : 1

m977*m104*0.1

nodelay

--

true

0

false

PMID: 18641647, 17653195 First, a recently described molecule termed DNA-dependent activator of IRFs (DAI) has been shown in vitro to act as a cytosolic DNA sensor by binding dsDNA and signalling through TBK1 and IRF3 to activate NF-kappaB and induce type I IFN production.

Go back
1203.0, 1159.0
25.0, 25.0

p71

p71

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e100 e101

MO000016632

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c216 : 1
stoichiometry:c218 : 1
stoichiometry:c217 : 1

m102*m103*0.1

nodelay

--

true

0

false

PMID: 18641647, 17653195 First, a recently described molecule termed DNA-dependent activator of IRFs (DAI) has been shown in vitro to act as a cytosolic DNA sensor by binding dsDNA and signalling through TBK1 and IRF3 to activate NF-kappaB and induce type I IFN production.

Go back
643.0, 1463.0
25.0, 25.0

p72

p72

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

MO000041456 e103 e164 e180

MO000016658

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c220 : 1
stoichiometry:c221 : 1
stoichiometry:c392 : 1
stoichiometry:c439 : 1
stoichiometry:c219 : 1

m19324*m105*0.1

nodelay

--

true

0

false

PMID: 18641647, 17653195 First, a recently described molecule termed DNA-dependent activator of IRFs (DAI) has been shown in vitro to act as a cytosolic DNA sensor by binding dsDNA and signalling through TBK1 and IRF3 to activate NF-kappaB and induce type I IFN production. PMID: 18641647 This ITAM-mediated pathway potently inhibits type I interferon (IFN) and cytokine production by pDCs in response to Toll-like receptor (TLR) activation. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL-6.

Go back
872.0, 264.0
23.0, 23.0

p73

p73

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000008179 e80 e105

e104

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c222 : 1
stoichiometry:c224 : 1
stoichiometry:c225 : 1
stoichiometry:c223 : 1

m1055*m82*m107*0.1

nodelay

--

true

0

false

PMID: 18641647, 18048689 For example, RNAs with short stem-loops can activate IFNinducible dsRNA-dependent protein kinase R (PKR) in a 5'-triphosphate-dependent manner, independent of RIG-I.

Go back
1110.0, 482.0
27.0, 27.0

p74

p74

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

MO000061281

e106 e109

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c227 : 1
stoichiometry:c226 : 1
stoichiometry:c231 : 1

m36179*0.1

nodelay

--

true

0

false

PMID: 18641647, 17653195 In addition, activation of the ribonuclease L by 2¡ì,5¡ì-linked oligoadenylate leads to the production of small RNA cleavage products from self RNA, which then function to amplify antiviral IFN responses.

Go back
958.0, 446.0
27.0, 27.0

p75

p75

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e107 e108

MO000061281

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c228 : 1
stoichiometry:c230 : 1
stoichiometry:c229 : 1

m109*m110*0.1

nodelay

--

true

0

false

PMID: 18641647, 17653195 In addition, activation of the ribonuclease L by 2¡ì,5¡ì-linked oligoadenylate leads to the production of small RNA cleavage products from self RNA, which then function to amplify antiviral IFN responses.

Go back
311.0, 1427.0
25.0, 25.0

p76

p76

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

MO000016660

e111

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c232 : 1
stoichiometry:c233 : 1

m1636*0.1

nodelay

--

true

0

false

PMID: 18641647, 11790540 In most cells, the production of IFN-alpha depends on type I IFN receptor (IFNAR) triggering by IFN-beta, which results in IRF7 induction.

Go back
119.0, 1498.0
23.0, 23.0

p77

p77

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e111 e110

e112

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c234 : 1
stoichiometry:c235 : 1
stoichiometry:c236 : 1

m113*m112*0.1

nodelay

--

true

0

false

PMID: 18641647, 11790540 In most cells, the production of IFN-alpha depends on type I IFN receptor (IFNAR) triggering by IFN-beta, which results in IRF7 induction.

Go back
698.0, 1282.0
27.0, 27.0

p78

p78

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G016992 e164 e112 e180

MO000016659

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c238 : 1
stoichiometry:c394 : 1
stoichiometry:c239 : 1
stoichiometry:c434 : 1
stoichiometry:c237 : 1

m98717*m114*0.1

nodelay

--

true

0

false

PMID: 18641647, 11790540 In most cells, the production of IFN-alpha depends on type I IFN receptor (IFNAR) triggering by IFN-beta, which results in IRF7 induction. PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 This ITAM-mediated pathway potently inhibits type I interferon (IFN) and cytokine production by pDCs in response to Toll-like receptor (TLR) activation. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL-6.

Go back
803.0, 1519.0
25.0, 25.0

p79

p79

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000007185

e103

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c241 : 1
stoichiometry:c240 : 1

m769*0.1

nodelay

--

true

0

false

PMID: 18641647, 17702615, 12538667 IRF8 can further amplify the IFN response during the second phase of type I IFN gene transcription in pDCs.

Go back
215.0, 551.0
25.0, 25.0

p8

p8

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

MO000042126 e27

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m19940*m27*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.

Go back
1335.0, 747.0
25.0, 25.0

p80

p80

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000016573 MO000007700 e114

e113

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c242 : 1
stoichiometry:c243 : 1
stoichiometry:c266 : 1
stoichiometry:c244 : 1

m1572*m979*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF. PMID: 18641647, 15665823 However, IRF4 competes with IRF5, but not IRF7, to interact with MyD88, thereby negatively regulating cytokine production induced by TLR stimulation.

Go back
1068.0, 1252.0
24.0, 24.0

p81

p81

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G016992

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c249 : 1
stoichiometry:c245 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
1019.0, 1311.0
25.0, 25.0

p82

p82

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c250 : 1
stoichiometry:c246 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
1020.0, 1372.0
23.0, 23.0

p83

p83

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

e75

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c251 : 1
stoichiometry:c247 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
1020.0, 1404.0
23.0, 23.0

p84

p84

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G012384

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c252 : 1
stoichiometry:c248 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
1103.0, 1447.0
25.0, 25.0

p85

p85

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G010329

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c255 : 1
stoichiometry:c254 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
1167.0, 1387.0
25.0, 25.0

p86

p86

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G010262

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c253 : 1
stoichiometry:c256 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
1075.0, 1563.0
25.0, 25.0

p87

p87

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G010859

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c258 : 1
stoichiometry:c257 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
1076.0, 1536.0
23.0, 23.0

p88

p88

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G012224

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c260 : 1
stoichiometry:c259 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
963.0, 1619.0
25.0, 25.0

p89

p89

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e113

G010691

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c261 : 1
stoichiometry:c262 : 1

m115*0.1

nodelay

--

true

0

false

PMID: 18641647, 17360658, 17513736, 15665823 Aside from IRF7, IRF5 directly interacts with MyD88 and mediates the TLR-dependent induction of type I IFNs and pro-inflammatory cytokines, including IL-6 and TNF.

Go back
230.0, 738.0
27.0, 27.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

e27 MO000042007

e29

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c25 : 1
stoichiometry:c26 : 1
stoichiometry:c27 : 1

m27*m19823*0.1

nodelay

--

true

0

false

PMID: 18641647 TLR7 and TLR8 respond to guanosine- or uridine-rich singlestranded RNA (ssRNA) from viruses and the synthetic imidazoquinoline compounds imiquimod and R?848.

Go back
1246.0, 594.0
27.0, 27.0

p90

p90

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000007697 MO000016573

e114

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c263 : 1
stoichiometry:c264 : 1
stoichiometry:c265 : 1

m978*m1572*0.1

nodelay

--

true

0

false

PMID: 18641647, 15665823 However, IRF4 competes with IRF5, but not IRF7, to interact with MyD88, thereby negatively regulating cytokine production induced by TLR stimulation.

Go back
584.0, 508.0
23.0, 23.0

p91

p91

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e115 MO000019398 e119

e116

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c267 : 1
stoichiometry:c270 : 1
stoichiometry:c273 : 1
stoichiometry:c276 : 1

m117*m3965*m121*0.1

nodelay

--

true

0

false

PMID: 18641647 Resting plasmacytoid dendritic cells (pDCs) predominantly express Toll-like receptor 7 (TLR7) and TLR9, which reside in the endoplasmic reticulum (ER) in association with UNC93B and gp96. PMID: 18641647, 16415873, 17452530 The delivery of TLRs to endolysosomes and their subsequent proper activation requires UNC93B, an ER-resident transmembrane protein that can specifically interact with TLR3, TLR7 and TLR9.

Go back
587.0, 587.0
25.0, 25.0

p92

p92

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e115 MO000042126 e119

e117

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c268 : 1
stoichiometry:c271 : 1
stoichiometry:c274 : 1
stoichiometry:c277 : 1

m117*m19940*m121*0.1

nodelay

--

true

0

false

PMID: 18641647 Resting plasmacytoid dendritic cells (pDCs) predominantly express Toll-like receptor 7 (TLR7) and TLR9, which reside in the endoplasmic reticulum (ER) in association with UNC93B and gp96. PMID: 18641647, 16415873, 17452530 The delivery of TLRs to endolysosomes and their subsequent proper activation requires UNC93B, an ER-resident transmembrane protein that can specifically interact with TLR3, TLR7 and TLR9.

Go back
630.0, 778.0
27.0, 27.0

p93

p93

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e115 MO000042012 e119

e118

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c269 : 1
stoichiometry:c272 : 1
stoichiometry:c275 : 1
stoichiometry:c278 : 1

m117*m19828*m121*0.1

nodelay

--

true

0

false

PMID: 18641647 Resting plasmacytoid dendritic cells (pDCs) predominantly express Toll-like receptor 7 (TLR7) and TLR9, which reside in the endoplasmic reticulum (ER) in association with UNC93B and gp96. PMID: 18641647, 16415873, 17452530 The delivery of TLRs to endolysosomes and their subsequent proper activation requires UNC93B, an ER-resident transmembrane protein that can specifically interact with TLR3, TLR7 and TLR9.

Go back
653.0, 1345.0
25.0, 25.0

p94

p94

cso30:i:ME_Translation

cso30:i:CC_Cytosol

--

G010228 e164 e180

MO000016660

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c279 : 1
stoichiometry:c393 : 1
stoichiometry:c436 : 1
stoichiometry:c280 : 1

m93217*0.1

nodelay

--

true

0

false

PMID: 18641647, 16415873 The prolonged retention of multimeric A-type CpG ODNs provides a platform for extended activation of the signal-transducing complex, consisting of MyD88 and IRF7, which leads to robust type I IFN production. PMID: 18641647 This ITAM-mediated pathway potently inhibits type I interferon (IFN) and cytokine production by pDCs in response to Toll-like receptor (TLR) activation. PMID: 18641647, 16735691, 17850179 Activation of the BCR-like signalling pathway in pDCs potently suppresses the activation of both TLR7 and TLR9, inhibiting the production of all type I IFNs, as well as TNF and IL-6.

Go back
143.0, 1175.0
25.0, 25.0

p95

p95

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

MO000000311 e132

e133

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c283 : 1
stoichiometry:c284 : 1
stoichiometry:c285 : 1

m230108*m134*0.1

nodelay

--

true

0

false

PMID: 18641647 The antimicrobial peptide LL37 is secreted by damaged epithelial cells or deposited by tissue-infiltrating neutrophils. It binds self-DNA fragments released by dying cells to form aggregated and condensed structures that are protected from extracellular nuclease degradation and delivered via lipid rafts from the extracellular environment into the early endosomes of plasmacytoid dendritic cells (pDCs).

Go back
75.0, 1243.0
25.0, 25.0

p96

p96

cso30:i:ME_Binding

cso30:i:CC_Extracellular

--

e133 e134

e135

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c286 : 1
stoichiometry:c287 : 1
stoichiometry:c288 : 1

m135*m136*0.1

nodelay

--

true

0

false

PMID: 18641647 Dying cells also release high-mobility group box 1 protein (HMGB1), which binds aggregated self-DNA?LL37 complexes and promotes their association with Toll-like receptor 9 (TLR9) in early endosomes by binding to RAGE (receptor for advanced glycation end-products). PMID: 18641647 Interestingly, in contrast to LL37, HMGB1 can only bind multimeric aggregated DNA structures, such as A-type CpG ODNs, and not monomeric DNA sequences, such as B-type CpG ODNs.

Go back
315.0, 1043.0
25.0, 25.0

p97

p97

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e136 e140

e137

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c290 : 1
stoichiometry:c340 : 1
stoichiometry:c328 : 1

m138*m142*0.1

nodelay

--

true

0

false

PMID: 18641647 Dying cells also release high-mobility group box 1 protein (HMGB1), which binds aggregated self-DNA?LL37 complexes and promotes their association with Toll-like receptor 9 (TLR9) in early endosomes by binding to RAGE (receptor for advanced glycation end-products).

Go back
447.0, 971.0
26.0, 26.0

p98

p98

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e137 MO000042012

e138 e136

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c329 : 1
stoichiometry:c330 : 1
stoichiometry:c331 : 1
stoichiometry:c332 : 1

m139*m19828*0.1

nodelay

--

true

0

false

PMID: 18641647 Dying cells also release high-mobility group box 1 protein (HMGB1), which binds aggregated self-DNA?LL37 complexes and promotes their association with Toll-like receptor 9 (TLR9) in early endosomes by binding to RAGE (receptor for advanced glycation end-products).

Go back
871.0, 1275.0
25.0, 25.0

p99

p99

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e121

G010240

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c282 : 1
stoichiometry:c291 : 1

m123*0.1

nodelay

--

true

0

false

PMID: 18641647, 11160284, 11561001, 7700380 On the other hand, B-type CpG ODNs can activate B cells but only trigger pDCs to produce the pro-inflammatory cytokines TNF and IL-6, and small amounts of IFN, as well as inducing the upregulation of CD80, CD86 and the expression of MHC class II molecules.

Go back
1037.0, 78.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1314.0, 324.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
736.0, 880.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
840.0, 668.8882762431303

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.671729547731, 434.26816351845963

c102

c102

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
800.4512399668456, 706.7309093090201

c103

c103

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
769.1283159748743, 850.6314062513511

c104

c104

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
977.0, 644.0

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1177.0, 1040.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1179.4452081011955, 1050.0

c107

c107

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1032.0, 655.0

c108

c108

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1045.0, 700.0

c109

c109

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1440.0, 319.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.406737666646, 712.0

c110

c110

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1033.0, 803.0

c111

c111

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
995.9960966086966, 855.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1046.0, 854.0

c113

c113

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
929.0, 945.7309093090201

c114

c114

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1171.0, 944.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1163.0, 954.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
991.8070718570434, 936.746318704865

c117

c117

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
990.9932582089723, 942.885143449429

c118

c118

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 879.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1322.0, 364.0

c12

c12

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
972.0, 944.0

c120

c120

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
989.6568542494924, 949.6568542494924

c121

c121

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
986.0, 1024.0

c122

c122

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
982.3332376839458, 1036.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
936.253768895108, 981.3738459977246

c124

c124

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1037.0, 978.4985898687328

c125

c125

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1040.0, 1005.3124295713869

c126

c126

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1040.0, 1028.0

c127

c127

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.9274714762033, 588.3110592491572

c128

c128

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
991.947271486969, 922.0

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.0, 500.0

c13

c13

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1171.9958409147175, 858.0

c130

c130

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.0, 868.0

c131

c131

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1105.0, 855.0

c132

c132

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1169.6564023547028, 912.0

c133

c133

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1231.0, 903.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1173.0, 1102.0

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.0, 1136.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1172.0, 760.0

c137

c137

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.0, 770.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
744.0, 474.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 548.0

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
964.0, 518.0

c140

c140

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1104.0, 778.7223731857939

c141

c141

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.0, 1163.0

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 1208.0

c143

c143

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.8195028725718, 1302.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
954.5032291936727, 1360.0

c145

c145

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
955.0, 1468.0

c146

c146

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.8446454055273, 1422.0

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1009.0, 1263.0

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1004.0, 1263.0

c149

c149

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
376.0, 528.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
996.219095869855, 1263.0

c150

c150

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
981.7390935125082, 1263.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1144.3592553320611, 1152.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1140.0, 1237.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1117.1324413127782, 1332.0

c154

c154

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1142.0, 1332.0

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1071.0745328934242, 1404.0

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1156.0, 1448.0

c157

c157

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1107.998146103803, 993.0

c158

c158

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1083.999999829609, 983.5231269324868

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
385.0, 684.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1050.984420627863, 1525.0

c160

c160

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 1600.0

c161

c161

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
87.97943099127485, 331.51899747667744

c162

c162

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
542.8823322690733, 1113.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
536.0, 1152.0

c164

c164

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
552.0, 1197.0

c165

c165

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
605.0, 1221.0

c166

c166

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
604.0, 1172.0

c167

c167

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
592.0, 1349.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.8911513906571, 1339.315191898443

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
456.0, 611.0

c17

c17

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
595.40026667774, 1277.0

c170

c170

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1177.0, 1056.0

c171

c171

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1180.982281262853, 1089.53215208419

c172

c172

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
451.82419511127375, 35.69494711687332

c173

c173

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1167.4854338271991, 957.0

c174

c174

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1161.0, 992.0

c175

c175

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
454.0, 52.13255517609855

c176

c176

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
320.1403292830891, 208.9987691360801

c177

c177

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
319.8303925497885, 44.0

c178

c178

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.0, 201.0

c179

c179

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.46338504034065, 689.0

c18

c18

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
420.0, 57.0

c180

c180

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
420.0, 248.0

c181

c181

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
432.0, 235.0

c182

c182

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
556.0, 249.0

c183

c183

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 241.0

c184

c184

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
430.0, 57.0

c185

c185

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.9619305082008, 256.3343588757586

c186

c186

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
712.0, 268.0

c187

c187

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
744.0, 283.0

c188

c188

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
659.0, 240.0

c189

c189

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
376.0, 872.0

c19

c19

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
645.9394765400795, 280.0

c190

c190

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
725.0, 328.0

c191

c191

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.0, 119.54906498322146

c192

c192

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
492.0, 155.99950684783897

c193

c193

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
624.0, 284.0

c194

c194

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 1116.0

c195

c195

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
60.02087245115251, 19.81901789505173

c196

c196

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 1104.0

c197

c197

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
404.0, 1231.0

c198

c198

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
422.5398594650478, 1240.0

c199

c199

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1050.0, 97.2694147517065

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
207.0, 872.0

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 1280.0

c200

c200

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 1267.5298221281348

c201

c201

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
537.0, 1208.0

c202

c202

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
550.0, 1261.0

c203

c203

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
820.6568542494924, 256.65685424949237

c204

c204

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 251.0

c205

c205

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 1172.0079224635572

c206

c206

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1100.0, 1147.7825416385167

c207

c207

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1107.5225221223284, 1178.7224365776046

c208

c208

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
433.0, 43.6851334502046

c209

c209

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
380.8415826524321, 880.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
817.0, 972.0

c210

c210

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
796.0, 985.0

c211

c211

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
796.1032172143252, 338.0

c212

c212

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
552.0, 1193.0

c213

c213

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.3599068047633, 1205.0

c214

c214

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
647.6917147073865, 1120.0

c215

c215

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1217.796029752168, 1191.9602975216799

c216

c216

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1178.9183115728806, 1150.017084139092

c217

c217

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
806.0, 19.830601878830066

c218

c218

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.9510698773889, 1466.8834522085988

c219

c219

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
247.02316458331507, 503.0

c22

c22

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
609.0, 1277.0

c220

c220

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
675.9962732193867, 1476.2441610143323

c221

c221

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
902.9876828256433, 277.4437601569802

c222

c222

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
884.0, 287.0

c223

c223

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.0, 51.0

c224

c224

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
863.0, 243.0

c225

c225

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1088.0, 496.0

c226

c226

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
988.0, 421.0

c227

c227

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
944.0, 439.0

c228

c228

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
972.0, 436.0

c229

c229

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
152.0, 564.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
991.2179589656599, 476.03358582934374

c230

c230

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1124.0, 509.0

c231

c231

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
343.8756224939967, 1395.0

c232

c232

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.99943985436144, 1440.0

c233

c233

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
131.0, 1453.0

c234

c234

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
149.4644445550967, 1474.0

c235

c235

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
142.0, 1510.0

c236

c236

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
148.9187406921522, 1298.0

c237

c237

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
732.7104889620335, 1302.1326884363073

c238

c238

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
249.0, 1305.2957384626716

c239

c239

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
240.0, 564.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
816.0, 1498.0

c240

c240

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.0, 1533.3262589561145

c241

c241

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1025.0, 399.0

c242

c242

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1228.0, 760.0

c243

c243

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1243.9999963908629, 772.0

c244

c244

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.8262546692157, 1271.0

c245

c245

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
953.613703039687, 1333.0

c246

c246

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
957.2362051439704, 1390.0

c247

c247

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
954.0961421925876, 1422.0

c248

c248

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1099.9949925666012, 1264.2830085864284

c249

c249

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
139.0, 575.0

c25

c25

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.6794655578944, 1273.0

c250

c250

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1049.8074888811523, 1277.0

c251

c251

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1049.295937309987, 1280.0

c252

c252

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1186.2987830845307, 1287.0

c253

c253

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1077.0, 1460.0

c254

c254

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1126.8215808360976, 1287.0

c255

c255

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1161.995473888266, 1412.0

c256

c256

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1026.6921915811265, 1580.0

c257

c257

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1107.9999867263036, 1287.0

c258

c258

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1050.5894663844042, 1535.5298221281348

c259

c259

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0703033307765, 691.0

c26

c26

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1106.9999203579873, 1287.0

c260

c260

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
995.9999919145489, 1287.0

c261

c261

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
930.6626102817692, 1618.2987830845307

c262

c262

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1193.0, 622.4950642846643

c263

c263

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1027.0, 398.0

c264

c264

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1202.9984625732538, 608.0

c265

c265

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1195.0, 622.0

c266

c266

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
614.3361207301938, 528.1908200563525

c267

c267

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
619.7795818292902, 562.0

c268

c268

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
654.7719548666504, 576.0

c269

c269

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 752.0

c27

c27

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 377.0

c270

c270

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.0, 496.0

c271

c271

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
374.0, 791.7228382270954

c272

c272

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.5411017337165, 532.6058645343921

c273

c273

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
599.8452097740558, 619.9999388905655

c274

c274

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.8971315643976, 653.0

c275

c275

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
607.0, 520.0

c276

c276

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 600.0

c277

c277

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
657.0, 792.0

c278

c278

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
685.9377110046612, 1360.9963653980747

c279

c279

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
157.0, 625.3622900637502

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
613.2455218124675, 1364.0

c280

c280

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.7611400011626, 1411.0

c281

c281

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
631.0, 1016.0

c282

c282

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
110.0, 1188.0

c283

c283

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
106.0, 1197.4997257507944

c284

c284

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
156.0, 1200.0

c285

c285

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
108.0, 1256.0

c286

c286

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
88.0, 1276.0

c287

c287

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
100.0, 1264.0

c288

c288

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
168.0, 1239.9425724154553

c289

c289

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
154.0, 699.0

c29

c29

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
348.0, 1056.0

c290

c290

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
896.0, 1288.0

c291

c291

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
627.0, 885.0

c292

c292

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
626.0561610125071, 893.8954737212622

c293

c293

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
615.5066103788897, 384.0

c294

c294

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
720.4667648496245, 981.0

c295

c295

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
710.0, 1009.0

c296

c296

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
697.0, 964.0

c297

c297

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
852.0, 1044.0

c298

c298

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
841.0, 1056.0

c299

c299

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 90.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.83821374750838, 508.0

c30

c30

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
757.0, 1045.7705935588815

c300

c300

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
898.0, 1104.8669836198026

c301

c301

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
945.0, 1112.0

c302

c302

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 1007.8087386821638

c303

c303

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
948.0, 1053.8296500773265

c304

c304

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.9900690358198, 600.4890260888835

c305

c305

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
683.9690388002031, 1409.7031504823708

c306

c306

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
822.9618846722624, 1483.0

c307

c307

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
808.0, 1635.0

c308

c308

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
871.0, 936.0

c309

c309

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.0, 608.0

c31

c31

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
593.0613012044827, 915.72987951681

c310

c310

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
789.0, 926.0

c311

c311

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1170.5240571578818, 869.0

c312

c312

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1164.0, 900.0

c313

c313

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
916.0, 900.012844201214

c314

c314

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1014.0, 1688.0

c315

c315

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1121.0, 1664.0

c316

c316

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1052.0, 1477.0

c317

c317

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1156.0, 1506.0

c318

c318

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
596.0, 908.0

c319

c319

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
263.1161785822062, 695.0

c32

c32

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
587.6497611570375, 384.0

c320

c320

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
658.0, 939.7570698754893

c321

c321

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1106.6564023547028, 1052.0

c322

c322

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1100.0, 1088.0

c323

c323

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.0, 1068.0

c324

c324

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1169.2839333778202, 773.0

c325

c325

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1163.0, 808.0

c326

c326

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
907.952928308955, 808.0120271931019

c327

c327

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
340.0, 1047.4310835055999

c328

c328

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
408.0, 1001.506083455352

c329

c329

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
257.0, 792.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.0, 884.0

c330

c330

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
473.0, 993.0

c331

c331

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
460.0, 997.0

c332

c332

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
530.0366581914285, 371.6231309777245

c333

c333

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
530.1311299219144, 901.998925236779

c334

c334

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
534.0, 894.0

c335

c335

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
690.8161052203985, 989.0

c336

c336

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0, 1052.0

c337

c337

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
591.0, 1028.0

c338

c338

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
265.0, 1224.0

c339

c339

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
249.9290958070508, 509.0

c34

c34

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
328.0, 1076.0

c340

c340

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
76.0, 1140.0

c341

c341

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
139.99970719386755, 1140.068445689299

c342

c342

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
120.0, 1091.0

c343

c343

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
134.0, 1064.0

c344

c344

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
190.65685424949237, 1082.6568542494924

c345

c345

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
185.0, 1057.9240068653964

c346

c346

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
252.0, 1010.4623275828736

c347

c347

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.27194393110386, 884.0

c348

c348

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
300.0, 992.0

c349

c349

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
260.1500930328753, 697.0

c35

c35

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.3238528289896, 1004.0

c350

c350

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
557.0, 1479.0

c351

c351

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
558.0, 1479.0

c352

c352

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
632.9999990474537, 1677.0

c353

c353

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
250.9549376844409, 438.95333299957696

c354

c354

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
157.0, 428.0

c355

c355

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
244.0, 426.1701742519246

c356

c356

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
623.9657030232805, 1482.0

c357

c357

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
577.4, 1480.8

c358

c358

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
35.68382228590258, 428.0

c359

c359

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
159.0, 836.0

c36

c36

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
112.0, 432.61115694427014

c360

c360

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
168.0, 1664.0

c361

c361

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
174.96659447277054, 1622.0

c362

c362

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
174.8361755317706, 1675.1553223820567

c363

c363

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
192.50999569531754, 1788.0

c364

c364

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
183.94571396153077, 1727.0

c365

c365

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
187.0, 1779.0950515759703

c366

c366

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
388.0, 1799.0

c367

c367

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
431.4652570302059, 1794.0

c368

c368

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
416.0, 1779.0

c369

c369

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
145.0, 667.1467338452597

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
474.0, 1795.0

c370

c370

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
522.2790621242674, 1788.0

c371

c371

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
504.0, 1763.0

c372

c372

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
352.0, 1612.0

c373

c373

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
344.0, 1623.0

c374

c374

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
354.76256170793187, 1621.0

c375

c375

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 1660.0

c376

c376

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
394.0, 1612.0

c377

c377

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
398.84844214594295, 1624.0

c378

c378

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
394.0, 1621.0

c379

c379

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 647.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
401.0, 1660.0

c380

c380

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
257.0, 1624.017084139092

c381

c381

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
280.0, 1679.6844428710842

c382

c382

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
446.8150839815766, 1631.0317234170236

c383

c383

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
420.0, 1680.8185851202143

c384

c384

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
498.84217130815114, 1621.465257030206

c385

c385

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
493.0, 1604.0

c386

c386

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 1616.0602868406304

c387

c387

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
491.0, 1540.0

c388

c388

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
540.0, 1540.0

c389

c389

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
256.0, 836.0

c39

c39

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
529.4437601569801, 1559.9876828256433

c390

c390

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.5144980382902, 1508.9100532816794

c391

c391

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
661.1286652959662, 1491.837462006285

c392

c392

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
667.210235332491, 1373.99447131733

c393

c393

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
679.0, 1312.9582976149645

c394

c394

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
691.0, 1550.0

c395

c395

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
691.0, 1546.0

c396

c396

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
690.0, 1558.0

c397

c397

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
252.0, 1560.0

c398

c398

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
349.7459217823134, 1577.5663617266162

c399

c399

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1328.0, 1697.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
436.17581958556076, 826.0

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
338.0, 1572.0

c400

c400

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.0, 1696.0

c401

c401

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
772.3517178529796, 1714.9463531699773

c402

c402

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
756.0, 1709.0

c403

c403

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
717.6076282594655, 1718.5398594650478

c404

c404

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
474.0, 1707.61329395742

c405

c405

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
673.0, 1700.0

c406

c406

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
703.807507511707, 919.6951648282165

c407

c407

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
662.0, 1590.0

c408

c408

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
638.0, 1608.0

c409

c409

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.0, 872.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.0, 1649.0

c410

c410

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
635.0, 1664.0

c411

c411

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
696.0688506262655, 1627.3879737298985

c412

c412

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
709.6157183455093, 1682.1362862082422

c413

c413

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
474.0, 1622.943954226452

c414

c414

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
474.0, 1673.6309072353858

c415

c415

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
578.9352584665878, 1446.0

c416

c416

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
726.6082725498476, 1450.4726885787004

c417

c417

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
628.0, 1462.0503201829345

c418

c418

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
623.0, 1462.3846153846155

c419

c419

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
256.0, 880.0

c42

c42

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
655.0, 1462.811876221479

c420

c420

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
883.0, 1761.0

c421

c421

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.8646187432906, 1748.0

c422

c422

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
829.5458827133112, 1763.6570009553914

c423

c423

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
262.0, 1338.563930917681

c424

c424

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
93.0, 1412.0

c425

c425

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
195.94922374651966, 1413.8999121222475

c426

c426

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
188.0, 1390.824458019474

c427

c427

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
232.3403601260162, 1287.0

c428

c428

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
227.0, 1328.0

c429

c429

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 188.0

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
90.0, 1329.420470664982

c430

c430

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
162.99811031059133, 496.0

c431

c431

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
155.0, 463.56059170105755

c432

c432

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
71.73554916943415, 500.0652102284993

c433

c433

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
274.0, 1297.282313088024

c434

c434

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
274.0, 1328.0

c435

c435

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
274.0, 1329.0

c436

c436

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
598.5186948628212, 1352.7004818488463

c437

c437

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
274.0, 1330.0

c438

c438

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
274.0, 1332.0

c439

c439

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
1101.0, 186.23209348210335

c44

c44

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
274.0, 1333.0

c440

c440

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
111.59040979931268, 1330.0

c441

c441

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
96.03288124607496, 1330.0

c442

c442

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
274.0, 1333.0

c443

c443

cso30:c:InputInhibitor

--

true true true true

cso30:c:InputInhibitor

threshold

--

0

1,

--

Go back
826.0, 1207.1583934409375

c444

c444

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
832.9556524591421, 1224.9520752608762

c445

c445

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
19.988459111934105, 387.8867762098472

c446

c446

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
188.97162819000525, 945.6731597138227

c447

c447

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
814.016075241693, 1261.2320934821034

c448

c448

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
771.6568542494924, 1215.6568542494924

c449

c449

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1090.0, 254.0

c45

c45

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
703.0, 964.0

c450

c450

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
772.2216722050282, 1287.0608695236933

c451

c451

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
725.1676940130167, 1242.0950515759703

c452

c452

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 1003.0

c453

c453

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1105.0, 290.0

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1194.0, 177.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 309.01946725397426

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1018.9322862329901, 183.0

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1396.0, 1678.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 273.0

c50

c50

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1000.0, 179.0

c51

c51

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
969.1995556481268, 171.0

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 259.0

c53

c53

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
960.0, 194.0

c54

c54

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1100.0, 305.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1188.1318755781376, 287.0

c56

c56

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1184.0, 416.0

c57

c57

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1196.2550717518177, 424.0

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1189.0, 476.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1332.0, 1725.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1027.0, 392.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
313.85423880472223, 374.0

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
168.0, 388.0

c62

c62

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
306.0, 390.0

c63

c63

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
392.0, 375.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
456.0, 407.0

c65

c65

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.22352944162975, 363.026696856701

c66

c66

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
418.0, 335.0237707010416

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
544.9996193014179, 332.0780450663553

c68

c68

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
476.0, 332.0

c69

c69

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1436.0, 220.0

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
564.076071235341, 380.3447681242425

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.6891021283702, 383.5855378207923

c71

c71

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
671.8654546545101, 384.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 437.46697086571646

c73

c73

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
576.0, 428.0

c74

c74

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
386.0, 716.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
664.0, 696.4790079429674

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
374.0, 839.6414587093152

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
685.0, 840.0

c78

c78

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
827.2339488917636, 494.78775933441466

c79

c79

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1311.0, 218.0

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
824.2808811836649, 495.29628800546374

c80

c80

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.7976291387107, 495.4948830012374

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
848.3417230863822, 614.0

c82

c82

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
854.4698886744255, 659.0

c83

c83

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
855.4837767493345, 698.8272045497487

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
830.2455626125934, 614.0

c85

c85

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.788935721519, 662.0

c86

c86

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
837.5023278166561, 732.0

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
726.3531602401445, 437.15135438863337

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.0, 692.0

c89

c89

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1320.0, 268.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
770.0, 840.0

c90

c90

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.9954075771187, 473.27103076532603

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
802.3148177390107, 702.0

c92

c92

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
743.4484561999482, 845.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
831.2542459584337, 494.03265276709044

c94

c94

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
845.1951186300456, 578.0

c95

c95

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.9402850002907, 578.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
780.0, 759.0

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1051.0, 644.0

c98

c98

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
917.0, 668.5279407321813

c99

c99

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back