1. Information
    majorVersion:3 minorVersion:0 projectID:local projectVersionID:undef fileName:/home/ikeda/eclipse/workspace/macrophage/csml/ok/csml/18694646.csml convertedTime:2009.07.01.11:21

  2. Original Literature
  3. Model OverView
  4. Model Abstracts
  5. Model Detail
  6. Download
Original Literature Model OverView
Publication
Title Innate immune response to viral infection.
Authors Koyama S, Ishii KJ, Coban C, Akira S.
Affiliation Laboratory of Host Defense, WPI Immunology Frontier Research Center, OsakaUniversity, 3-1 Yamada-oka, Suita, Japan.
Abstract In viral infections the host innate immune system is meant to act as a firstline defense to prevent viral invasion or replication before more specificprotection by the adaptive immune system is generated. In the innate immuneresponse, pattern recognition receptors (PRRs) are engaged to detect specificviral components such as viral RNA or DNA or viral intermediate products and toinduce type I interferons (IFNs) and other pro-inflammatory cytokines in theinfected cells and other immune cells. Recently these innate immune receptorsand their unique downstream pathways have been identified. Here, we summarizetheir roles in the innate immune response to virus infection, discriminationbetween self and viral nucleic acids and inhibition by virulent factors andprovide some recent advances in the coordination between innate and adaptiveimmune activation.
PMID 18694646
Model Abstract

Entity

G010228:IFN-beta MO000000030:PI3K MO000000048:AKT MO000000058:NF-kappaB MO000000065:RIP1 MO000000077:MAPKs{active} MO000000210:IKK-alpha:IKKbeta:IKKgamma MO000000212:TRAF6 MO000000213:IRAK MO000000276:AP-1 MO000007685:IRF-1 MO000007694:IRF-3 MO000007702:IRF-7 MO000016573:MyD88 MO000016574:TAK1 MO000016828:Caspase-1 MO000016899:FADD MO000016900:Caspase-8 MO000016906:Caspase-10 MO000016963:TRAF3 MO000017669:proCaspase-8 MO000018276:proCaspase-10 MO000019241:RIP3 MO000019331:TBK1:IKK-i MO000019398:TLR3 MO000022224:dsRNA MO000039077:IRAK-4 MO000041125:TRIF MO000041437:dsRNA:TLR3:TRIF MO000041446:dsRNA:TLR3 MO000041456:IRF-3{p} MO000041457:IRF-7{p} MO000042012:TLR9 MO000042126:TLR7 MO000044014:ASC MO000066987:DDX58 MO000094908:MAVS MO000103999:IFIH1 MO000116924:Cryopyrin e1: e10: e11:IKK-alpha:IKKbeta:IKKgamma{active} e12:MAPKs e13:ssRNA e14:NF-kappaB{active} e15:Viral RNA e16:AP-1{active} e17:Type I IFN e18:TBK1:IKK-i{active} e19:CpG DNA e2: e20:IRF-3{active} e21:dsRNA:TLR3{p} e22:dsRNA:TLR3{p}:PI3K e23:AKT{active} e24:dsRNA e25:DDX58:dsRNA e26:TLR9:CpG DNA e27:DDX58:ssRNA e28:IFIH1:dsRNA e29:Poly-IC e3: e30:IFIH1:Poly-IC e31:DDX58:dsRNA:MAVS e32:IFIH1:dsRNA:MAVS e33:DDX58:dsRNA:MAVS:TRAF3 e34:IFIH1:dsRNA:MAVS:TRAF3 e35:TLR9:CpG DNA:MyD88 e36:Viral RNA:TLR7 e37:Viral RNA:TLR7:MyD88 e38:IKK-alpha e39:TLR7:Viral RNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha:IRF-7 e4: e40:TLR9:CpG DNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha:IRF-7 e41:Cytokines e42:IRF-7{active} e43:IRF-1{active} e44:Cryopyrin:ssRNA e45:Cryopyrin:dsRNA e46:ASC{active} e47:Caspase-1{active} e48: e49: e5:dsRNA:TLR3:TRIF:TRAF3:TRAF6:RIP1:RIP3 e50: e51: e52: e53: e54: e55: e56: e57: e58: e59: e6:TAK1{active} e60: e61: e62: e63: e64: e65: e66: e67:TLR9 e68:TLR7 e69:UNC93B1 e7: e70:IFIH1:dsRNA:MAVS:FADD e71:DDX58:dsRNA:MAVS:FADD e72:TLR7:Viral RNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha e8: e9:

Process

p1 p10 p11 p12 p13 p14 p15 p16 p17 p18 p19 p2 p20 p21 p22 p23 p24 p25 p26 p27 p28 p29 p3 p30 p31 p32 p33 p34 p35 p36 p37 p38 p39 p4 p40 p41 p42 p43 p44 p45 p46 p47 p48 p49 p5 p50 p51 p52 p53 p54 p55 p56 p57 p58 p59 p6 p60 p61 p7 p8 p9
Model Detail
688.0, 1436.0
24.0, 24.0

IFN-beta

--

G010228

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p46

--

true true true true

csml-variable:Double

m93217

10

false

infinite

0

unit false false false
TRANSFACG010228

--

Go back
710.0, 826.0
20.0, 20.0

PI3K

--

MO000000030

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p18

true true true true

csml-variable:Double

m27

10

false

infinite

0

unit false false false
TRANSPATHMO000000030

--

Go back
842.0, 810.0
20.0, 20.0

AKT

--

MO000000048

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p19

true true true true

csml-variable:Double

m45

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
236.0, 1048.0
24.0, 24.0

NF-kappaB

--

MO000000058

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p7 p60 p61

true true true true

csml-variable:Double

m14

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
555.0, 287.0
18.0, 18.0

RIP1

--

MO000000065

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m6

10

false

infinite

0

unit false false false
InterProIPR000198
TRANSPATHMO000000065

--

Go back
509.0, 849.0
22.0, 22.0

MAPKs{active}

--

MO000000077

cso30:c:Protein

cso30:i:CC_CellComponent

--

p6

p8

true true true true

csml-variable:Double

m69

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
273.0, 905.0
22.0, 22.0

IKK-alpha:IKKbeta:IKKgamma

--

MO000000210

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p5

true true true true

csml-variable:Double

m181

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
526.0, 334.0
20.0, 20.0

TRAF6

--

MO000000212

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p37 p15

true true true true

csml-variable:Double

m183

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000000212

--

Go back
995.0, 287.0
18.0, 18.0

IRAK

--

MO000000213

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p15

true true true true

csml-variable:Double

m184

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000213

--

Go back
442.0, 990.0
19.0, 19.0

AP-1

--

MO000000276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p8

true true true true

csml-variable:Double

m219

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
1002.0, 974.0
20.0, 20.0

IRF-1

--

MO000007685

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p45

true true true true

csml-variable:Double

m970

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
597.0, 837.0
21.0, 21.0

IRF-3

--

MO000007694

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p14 p20 p31

true true true true

csml-variable:Double

m977

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
877.0, 933.0
22.0, 22.0

IRF-7

--

MO000007702

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p32 p37 p15

true true true true

csml-variable:Double

m980

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
1122.0, 338.0
20.0, 20.0

MyD88

--

MO000016573

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p36 p10

true true true true

csml-variable:Double

m1572

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000016573

--

Go back
528.0, 520.0
24.0, 24.0

TAK1

--

MO000016574

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p4 p43 p44

true true true true

csml-variable:Double

m1573

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
927.0, 183.0
26.0, 26.0

Caspase-1

--

MO000016828

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p51

true true true true

csml-variable:Double

m1765

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
230.0, 630.0
20.0, 20.0

FADD

--

MO000016899

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p54 p55

true true true true

csml-variable:Double

m1814

10

false

infinite

0

unit false false false
InterProIPR001875
TRANSPATHMO000016899

--

Go back
230.0, 810.0
20.0, 20.0

Caspase-8

--

MO000016900

cso30:c:Protein

cso30:i:CC_CellComponent

--

p56 p57

p60

true true true true

csml-variable:Double

m1815

10

false

infinite

0

unit false false false
TRANSPATHMO000016900

--

Go back
320.0, 864.0
24.0, 24.0

Caspase-10

--

MO000016906

cso30:c:Protein

cso30:i:CC_CellComponent

--

p58 p59

p61

true true true true

csml-variable:Double

m1821

10

false

infinite

0

unit false false false
TRANSPATHMO000016906

--

Go back
542.0, 450.0
20.0, 20.0

TRAF3

--

MO000016963

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3 p27 p28 p37 p15

true true true true

csml-variable:Double

m1872

10

false

infinite

0

unit false false false
InterProIPR001841
TRANSPATHMO000016963

--

Go back
199.0, 747.0
18.0, 18.0

proCaspase-8

--

MO000017669

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p56 p57

true true true true

csml-variable:Double

m2432

10

false

infinite

0

unit false false false
InterProIPR001309
TRANSPATHMO000017669

--

Go back
322.0, 786.0
20.0, 20.0

proCaspase-10

--

MO000018276

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p58 p59

true true true true

csml-variable:Double

m2932

10

false

infinite

0

unit false false false
InterProIPR001309
TRANSPATHMO000018276

--

Go back
526.0, 394.0
20.0, 20.0

RIP3

--

MO000019241

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p3

true true true true

csml-variable:Double

m3825

10

false

infinite

0

unit false false false
TRANSPATHMO000019241

--

Go back
589.0, 581.0
29.0, 29.0

TBK1:IKK-i

--

MO000019331

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p13 p29 p30

true true true true

csml-variable:Double

m3902

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
767.0, 335.0
18.0, 18.0

TLR3

--

MO000019398

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m3965

10

false

infinite

0

unit false false false
InterProIPR000157
TRANSPATHMO000019398

--

Go back
680.0, 36.0
24.0, 24.0

dsRNA

--

MO000022224

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p1

true true true true

csml-variable:Double

m119368

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
1102.0, 586.0
19.0, 19.0

IRAK-4

--

MO000039077

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p15

true true true true

csml-variable:Double

m17258

10

false

infinite

0

unit false false false
TRANSPATHMO000039077

--

Go back
619.0, 319.0
18.0, 18.0

TRIF

--

MO000041125

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p2

true true true true

csml-variable:Double

m18998

10

false

infinite

0

unit false false false
TRANSPATHMO000041125

--

Go back
726.0, 458.0
27.0, 27.0

dsRNA:TLR3:TRIF

--

MO000041437

cso30:c:Protein

cso30:i:CC_CellComponent

--

p2

p3

true true true true

csml-variable:Double

m19305

10

false

infinite

0

unit false false false
TRANSPATHMO000041437

--

Go back
729.0, 397.0
22.0, 22.0

dsRNA:TLR3

--

MO000041446

cso30:c:Protein

cso30:i:CC_CellComponent

--

p1

p2 p17

true true true true

csml-variable:Double

m19314

10

false

infinite

0

unit false false false
TRANSPATHMO000041446

--

Go back
558.0, 946.0
20.0, 20.0

IRF-3{p}

--

MO000041456

cso30:c:Protein

cso30:i:CC_CellComponent

--

p31

p33

true true true true

csml-variable:Double

m19324

10

false

infinite

0

unit false false false
TRANSPATHMO000041456

--

Go back
794.0, 970.0
19.0, 19.0

IRF-7{p}

--

MO000041457

cso30:c:Protein

cso30:i:CC_CellComponent

--

p32

p34

true true true true

csml-variable:Double

m19325

10

false

infinite

0

unit false false false
TRANSPATHMO000041457

--

Go back
919.0, 571.0
18.0, 18.0

TLR9

--

MO000042012

cso30:c:Protein

cso30:i:CC_CellComponent

--

p53

p9

true true true true

csml-variable:Double

m19828

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
829.0, 325.0
22.0, 22.0

TLR7

--

MO000042126

cso30:c:Protein

cso30:i:CC_CellComponent

--

p52

p35

true true true true

csml-variable:Double

m19940

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
702.0, 174.0
20.0, 20.0

ASC

--

MO000044014

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p49 p50

true true true true

csml-variable:Double

m21736

10

false

infinite

0

unit false false false
InterProIPR004020
TRANSPATHMO000044014

--

Go back
218.0, 358.0
20.0, 20.0

DDX58

--

MO000066987

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p22

true true true true

csml-variable:Double

m41844

10

false

infinite

0

unit false false false
TRANSPATHMO000066987

--

Go back
393.0, 385.0
22.0, 22.0

MAVS

--

MO000094908

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p25 p26

true true true true

csml-variable:Double

m68199

10

false

infinite

0

unit false false false
TRANSPATHMO000094908

--

Go back
282.0, 482.0
20.0, 20.0

IFIH1

--

MO000103999

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p23 p24

true true true true

csml-variable:Double

m76904

10

false

infinite

0

unit false false false
TRANSPATHMO000103999

--

Go back
526.0, 174.0
20.0, 20.0

Cryopyrin

--

MO000116924

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p47 p48

true true true true

csml-variable:Double

m86033

10

false

infinite

0

unit false false false
TRANSPATHMO000116924

--

Go back
109.90607455593346, 72.76685995349969
1135.1171577180726, 1648.1901130066396

--

e1

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane

--

--

--

true true true true

csml-variable:Double

m1

0

false

infinite

0

unit false true false

--

Go back
116.09569593212328, 122.59528484347736
1088.066439890175, 1530.6035334315095

--

e10

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytosol

--

--

--

true true true true

csml-variable:Double

m10

0

false

infinite

0

unit false true false

--

Go back
377.0, 989.0
22.0, 22.0

IKK-alpha:IKKbeta:IKKgamma{active}

--

e11

cso30:c:Protein

cso30:i:CC_CellComponent

--

p5

p7

true true true true

csml-variable:Double

m12

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
425.0, 877.0
22.0, 22.0

MAPKs

--

e12

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p6

true true true true

csml-variable:Double

m13

10

false

infinite

0

unit false false false
TRANSPATHMO000000077

--

Go back
418.0, 256.5
60.0, 31.0

ssRNA

--

e13

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p22 p47

true true true true

csml-variable:Double

m15

0

false

infinite

0

unit false false false

--

Go back
284.0, 1128.0
24.0, 24.0

NF-kappaB{active}

--

e14

cso30:c:Protein

cso30:i:CC_CellComponent

--

p7 p60 p61

p11 p41 p38

true true true true

csml-variable:Double

m16

10

false

infinite

0

unit false false false
TRANSPATHMO000000058

--

Go back
762.0, 244.5
60.0, 31.0

Viral RNA

--

e15

cso30:c:Rna

cso30:i:CC_Cytosol

--

--

p35

true true true true

csml-variable:Double

m17

0

false

infinite

0

unit false false false

--

Go back
530.0, 1014.0
19.0, 19.0

AP-1{active}

--

e16

cso30:c:Protein

cso30:i:CC_CellComponent

--

p8

p12

true true true true

csml-variable:Double

m18

10

false

infinite

0

unit false false false
TRANSPATHMO000000276

--

Go back
456.0, 1391.0
47.85467128027682, 25.522491349480973

Type I IFN

--

e17

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p11 p12 p16 p33 p34 p40 p41

--

true true true true

csml-variable:Double

m19

0

false

infinite

0

unit false false false

--

Go back
625.0, 653.0
29.0, 29.0

TBK1:IKK-i{active}

--

e18

cso30:c:Protein

cso30:i:CC_CellComponent

--

p13 p29 p30

p31 p32

true true true true

csml-variable:Double

m20

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000019331

--

Go back
1030.0, 688.0
60.0, 16.0

CpG DNA

--

e19

cso30:c:Dna

cso30:i:CC_Cytosol

--

--

p9

true true true true

csml-variable:Double

m21

0

false

infinite

0

unit false false false

--

Go back
109.90607455593346, 72.76685995349969
1135.1171577180726, 1648.1901130066396

--

e2

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_ExternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m2

0

false

infinite

0

unit false true false

--

Go back
646.0, 994.0
19.0, 19.0

IRF-3{active}

--

e20

cso30:c:Protein

cso30:i:CC_CellComponent

--

p14 p20

p16

true true true true

csml-variable:Double

m22

10

false

infinite

0

unit false false false
InterProIPR008984
TRANSPATHMO000007694

--

Go back
809.0, 452.0
30.121951219512194, 24.097560975609763

dsRNA:TLR3{p}

--

e21

cso30:c:Protein

cso30:i:CC_EndosomeLumen

--

p17

p18

true true true true

csml-variable:Double

m23

0

false

infinite

0

unit false false false

--

Go back
790.5, 620.0
19.433427762039656, 23.796033994334284

dsRNA:TLR3{p}:PI3K

--

e22

cso30:c:Complex

cso30:i:CC_Cytosol

--

p18

p19

true true true true

csml-variable:Double

m24

0

false

infinite

0

unit false false false

--

Go back
786.0, 818.0
19.0, 19.0

AKT{active}

--

e23

cso30:c:Protein

cso30:i:CC_CellComponent

--

p19

p20

true true true true

csml-variable:Double

m25

10

false

infinite

0

unit false false false
TRANSPATHMO000000048

--

Go back
220.0, 260.0
24.0, 24.0

dsRNA

--

e24

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p21 p23 p48

true true true true

csml-variable:Double

m26

10

false

infinite

0

unit false false false
TRANSPATHMO000022224

--

Go back
329.5, 359.0
20.91951341443093, 25.61573071154808

DDX58:dsRNA

--

e25

cso30:c:Complex

cso30:i:CC_Cytosol

--

p21

p25

true true true true

csml-variable:Double

m28

0

false

infinite

0

unit false false false

--

Go back
881.5, 588.0
20.4242490681868, 39.53080464810349

TLR9:CpG DNA

--

e26

cso30:c:Complex

cso30:i:CC_Cytosol

--

p9

p10

true true true true

csml-variable:Double

m29

0

false

infinite

0

unit false false false

--

Go back
410.5, 316.0
18.90268288618563, 23.146142309615062

DDX58:ssRNA

--

e27

cso30:c:Complex

cso30:i:CC_Cytosol

--

p22

--

true true true true

csml-variable:Double

m30

0

false

infinite

0

unit false false false

--

Go back
326.5, 433.0
18.527078820196635, 22.68621896350608

IFIH1:dsRNA

--

e28

cso30:c:Complex

cso30:i:CC_Cytosol

--

p23

p26

true true true true

csml-variable:Double

m31

0

false

infinite

0

unit false false false

--

Go back
197.0, 415.0
45.769554247266605, 25.936080740117745

Poly-IC

--

e29

cso30:c:SmallMolecule

cso30:i:CC_Cytosol

--

--

p24

true true true true

csml-variable:Double

m32

0

false

infinite

0

unit false false false

--

Go back
132.60841771029496, 95.46920310786118
1089.7124714093482, 1602.7854266979189

--

e3

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_IntegralToPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m3

0

false

infinite

0

unit false true false

--

Go back
217.5, 539.0
21.997333777703716, 26.935510748208632

IFIH1:Poly-IC

--

e30

cso30:c:Complex

cso30:i:CC_Cytosol

--

p24

--

true true true true

csml-variable:Double

m33

0

false

infinite

0

unit false false false

--

Go back
426.5, 474.0
19.71260781794824, 27.505964397137085

DDX58:dsRNA:MAVS

--

e31

cso30:c:Complex

cso30:i:CC_Cytosol

--

p25

p27 p55

true true true true

csml-variable:Double

m34

0

false

infinite

0

unit false false false

--

Go back
358.5, 570.0
19.71260781794824, 27.505964397137085

IFIH1:dsRNA:MAVS

--

e32

cso30:c:Complex

cso30:i:CC_Cytosol

--

p26

p28 p54

true true true true

csml-variable:Double

m35

0

false

infinite

0

unit false false false

--

Go back
496.0, 535.0
19.411764705882355, 32.352941176470594

DDX58:dsRNA:MAVS:TRAF3

--

e33

cso30:c:Complex

cso30:i:CC_Cytosol

--

p27

p29

true true true true

csml-variable:Double

m36

0

false

infinite

0

unit false false false

--

Go back
414.0, 628.0
19.411764705882355, 32.352941176470594

IFIH1:dsRNA:MAVS:TRAF3

--

e34

cso30:c:Complex

cso30:i:CC_Cytosol

--

p28

p30

true true true true

csml-variable:Double

m37

0

false

infinite

0

unit false false false

--

Go back
866.5, 662.0
19.641585612038902, 27.406863644705453

TLR9:CpG DNA:MyD88

--

e35

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p10

p15

true true true true

csml-variable:Double

m38

0

false

infinite

0

unit false false false

--

Go back
891.5, 363.0
17.161806621354962, 33.216399912299934

Viral RNA:TLR7

--

e36

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p35

p36

true true true true

csml-variable:Double

m39

0

false

infinite

0

unit false false false

--

Go back
922.5, 434.0
19.617911543402464, 27.373830060561588

Viral RNA:TLR7:MyD88

--

e37

cso30:c:Complex

cso30:i:CC_EndosomeLumen

--

p36

p37

true true true true

csml-variable:Double

m40

0

false

infinite

0

unit false false false

--

Go back
1034.0, 794.0
19.0, 19.0

IKK-alpha

--

e38

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p37 p15

true true true true

csml-variable:Double

m41

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000000210

--

Go back
904.6470588235294, 499.4117647058823
15.52941176470588, 25.88235294117648

TLR7:Viral RNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha:IRF-7

--

e39

cso30:c:Complex

cso30:i:CC_Cytosol

--

p37

p39 p43

true true true true

csml-variable:Double

m42

0

false

infinite

0

unit false false false

--

Go back
174.60775254586378, 135.1983036279934
1005.7138017382107, 1523.3272256576504

--

e4

cso30:c:EntityBiologicalCompartment

cso30:i:CC_PlasmaMembrane_InternalSideOfPlasmaMembrane_

--

--

--

true true true true

csml-variable:Double

m4

0

false

infinite

0

unit false true false

--

Go back
836.6470588235293, 735.4117647058824
18.794117647058822, 31.323529411764714

TLR9:CpG DNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha:IRF-7

--

e40

cso30:c:Complex

cso30:i:CC_Cytosol

--

p15

p44 p45

true true true true

csml-variable:Double

m43

0

false

infinite

0

unit false false false

--

Go back
609.0, 1364.0
45.83044982698962, 24.442906574394463

Cytokines

--

e41

cso30:c:mRNA

cso30:i:CC_Nucleoplasm

--

p42 p38

--

true true true true

csml-variable:Double

m44

0

false

infinite

0

unit false false false

--

Go back
821.0, 1037.0
22.0, 22.0

IRF-7{active}

--

e42

cso30:c:Protein

cso30:i:CC_CellComponent

--

p39

p40 p42

true true true true

csml-variable:Double

m46

10

false

infinite

0

unit false false false
TRANSPATHMO000007702

--

Go back
890.0, 1014.0
20.0, 20.0

IRF-1{active}

--

e43

cso30:c:Protein

cso30:i:CC_CellComponent

--

p45

p46

true true true true

csml-variable:Double

m47

10

false

infinite

0

unit false false false
InterProIPR001346
TRANSPATHMO000007685

--

Go back
556.0, 243.0
23.41988950276243, 26.022099447513813

Cryopyrin:ssRNA

--

e44

cso30:c:Complex

cso30:i:CC_Cytosol

--

p47

p49

true true true true

csml-variable:Double

m48

0

false

infinite

0

unit false false false

--

Go back
328.0, 215.0
23.41988950276243, 26.022099447513813

Cryopyrin:dsRNA

--

e45

cso30:c:Complex

cso30:i:CC_Cytosol

--

p48

p50

true true true true

csml-variable:Double

m49

0

false

infinite

0

unit false false false

--

Go back
802.0, 206.0
20.0, 20.0

ASC{active}

--

e46

cso30:c:Protein

cso30:i:CC_CellComponent

--

p49 p50

p51

true true true true

csml-variable:Double

m63

10

false

infinite

0

unit false false false
InterProIPR004020
TRANSPATHMO000044014

--

Go back
1039.0, 243.0
26.0, 26.0

Caspase-1{active}

--

e47

cso30:c:Protein

cso30:i:CC_CellComponent

--

p51

--

true true true true

csml-variable:Double

m64

10

false

infinite

0

unit false false false
TRANSPATHMO000016828

--

Go back
855.9738411474372, 1127.25
271.9043976240346, 82.18332275453143

--

e48

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_IntegralToMembrane_

--

--

--

true true true true

csml-variable:Double

m65

0

false

infinite

0

unit false true false

--

Go back
855.9738411474372, 1127.25
271.9043976240346, 82.18332275453143

--

e49

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToExternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m66

0

false

infinite

0

unit false true false

--

Go back
738.0, 567.0
20.29411764705883, 33.823529411764696

dsRNA:TLR3:TRIF:TRAF3:TRAF6:RIP1:RIP3

--

e5

cso30:c:Complex

cso30:i:CC_Cytosol

--

p3

p4 p13 p14

true true true true

csml-variable:Double

m5

0

false

infinite

0

unit false false false

--

Go back
287.54443123364575, 1067.3539308053685
529.6522596529801, 480.3364067988856

--

e50

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelopeLumen

--

--

--

true true true true

csml-variable:Double

m50

0

false

infinite

0

unit false true false

--

Go back
344.7508205443959, 1078.7372053472038
309.7035559237166, 465.541650942657

--

e51

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearPore

--

--

--

true true true true

csml-variable:Double

m51

0

false

infinite

0

unit false true false

--

Go back
294.44865063321913, 1073.7649916764008
515.8438208538338, 467.51428505682065

--

e52

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearInnerMembrane

--

--

--

true true true true

csml-variable:Double

m52

0

false

infinite

0

unit false true false

--

Go back
295.4349676903009, 1074.7513087334828
513.8711867396697, 465.541650942657

--

e53

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearLumen

--

--

--

true true true true

csml-variable:Double

m53

0

false

infinite

0

unit false true false

--

Go back
287.54443123364575, 1067.3539308053685
529.6522596529801, 480.3364067988856

--

e54

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearOuterMembrane

--

--

--

true true true true

csml-variable:Double

m54

0

false

infinite

0

unit false true false

--

Go back
287.54443123364575, 1067.3539308053685
529.6522596529801, 480.3364067988856

--

e55

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleus

--

--

--

true true true true

csml-variable:Double

m55

0

false

infinite

0

unit false true false

--

Go back
295.4349676903009, 1074.7513087334828
513.8711867396697, 465.541650942657

--

e56

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleoplasm

--

--

--

true true true true

csml-variable:Double

m56

0

false

infinite

0

unit false true false

--

Go back
674.1807176097504, 1264.617342221749
33.0897630066198, 29.95494335336112

--

e57

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearBody

--

--

--

true true true true

csml-variable:Double

m57

0

false

infinite

0

unit false true false

--

Go back
587.3848165865433, 1402.7017302132142
93.70012042278046, 84.8232669090435

--

e58

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Nucleolus

--

--

--

true true true true

csml-variable:Double

m58

0

false

infinite

0

unit false true false

--

Go back
287.54443123364575, 1067.3539308053685
529.6522596529801, 480.3364067988856

--

e59

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearEnvelope

--

--

--

true true true true

csml-variable:Double

m59

0

false

infinite

0

unit false true false

--

Go back
484.0, 604.0
24.0, 24.0

TAK1{active}

--

e6

cso30:c:Protein

cso30:i:CC_CellComponent

--

p4 p43 p44

p5 p6

true true true true

csml-variable:Double

m11

10

false

infinite

0

unit false false false
InterProIPR000719
TRANSPATHMO000016574

--

Go back
412.38048868571616, 1280.8114609343893
16.773308820963894, 8.076037580464108

--

e60

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Chromatin

--

--

--

true true true true

csml-variable:Double

m60

0

false

infinite

0

unit false true false

--

Go back
411.82038042596514, 1256.726805765093
57.41109662448414, 103.33997392407146

--

e61

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearChromosome

--

--

--

true true true true

csml-variable:Double

m61

0

false

infinite

0

unit false true false

--

Go back
435.9050355952613, 1323.9397969352208
8.961732156017028, 8.961732156017035

--

e62

cso30:c:EntityBiologicalCompartment

cso30:i:CC_NuclearCentromere

--

--

--

true true true true

csml-variable:Double

m62

0

false

infinite

0

unit false true false

--

Go back
860.7824398192449, 1132.0585986718074
262.28720028041926, 72.56612541091603

--

e63

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulumLumen

--

--

--

true true true true

csml-variable:Double

m67

0

false

infinite

0

unit false true false

--

Go back
855.9738411474372, 1127.25
271.9043976240346, 82.18332275453143

--

e64

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_Membrane_

--

--

--

true true true true

csml-variable:Double

m68

0

false

infinite

0

unit false true false

--

Go back
859.9081491516434, 1131.1843080042063
264.03578161562206, 74.31470674611879

--

e65

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum_ExtrinsicToInternalSideOfMembrane_

--

--

--

true true true true

csml-variable:Double

m70

0

false

infinite

0

unit false true false

--

Go back
858.5967131502412, 1129.8728720028041
266.65865361842634, 76.93757874892302

--

e66

cso30:c:EntityBiologicalCompartment

cso30:i:CC_EndoplasmicReticulum

--

--

--

true true true true

csml-variable:Double

m71

0

false

infinite

0

unit false true false

--

Go back
1043.0, 1135.0
18.0, 18.0

TLR9

--

e67

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p53

true true true true

csml-variable:Double

m72

10

false

infinite

0

unit false false false
TRANSPATHMO000042012

--

Go back
917.0, 1125.0
22.0, 22.0

TLR7

--

e68

cso30:c:Protein

cso30:i:CC_CellComponent

--

--

p52

true true true true

csml-variable:Double

m73

10

false

infinite

0

unit false false false
TRANSPATHMO000042126

--

Go back
963.0, 1185.5
34.23223988730127, 21.109881263835785

UNC93B1

--

e69

cso30:c:Protein

cso30:i:CC_Cytosol

--

--

p52 p53

true true true true

csml-variable:Double

m74

0

false

infinite

0

unit false false false

--

Go back
193.32939384679239, 139.82342358961904
966.0111150176506, 1368.812797663387

--

e7

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell

--

--

--

true true true true

csml-variable:Double

m7

0

false

infinite

0

unit false true false

--

Go back
330.0, 672.0
19.147058823529417, 31.911764705882348

IFIH1:dsRNA:MAVS:FADD

--

e70

cso30:c:Complex

cso30:i:CC_Cytosol

--

p54

p56 p59

true true true true

csml-variable:Double

m75

0

false

infinite

0

unit false false false

--

Go back
386.0, 720.0
19.147058823529417, 31.911764705882348

DDX58:dsRNA:MAVS:FADD

--

e71

cso30:c:Complex

cso30:i:CC_Cytosol

--

p55

p57 p58

true true true true

csml-variable:Double

m76

0

false

infinite

0

unit false false false

--

Go back
960.6470588235294, 527.4117647058823
15.52941176470588, 25.88235294117648

TLR7:Viral RNA:MyD88:IRAK1:IRAK4:TRAF3:TRAF6:IKK-alpha

--

e72

cso30:c:Complex

cso30:i:CC_Cytosol

--

p39

--

true true true true

csml-variable:Double

m77

0

false

infinite

0

unit false false false

--

Go back
181.35083568303105, 181.41516119174685
811.3145257378492, 1178.0286913713576

--

e8

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cell_WithoutCellWall_

--

--

--

true true true true

csml-variable:Double

m8

0

false

infinite

0

unit false true false

--

Go back
189.4080139130006, 202.56525404541696
807.6104298939349, 1162.579140271303

--

e9

cso30:c:EntityBiologicalCompartment

cso30:i:CC_Cytoplasm

--

--

--

true true true true

csml-variable:Double

m9

0

false

infinite

0

unit false true false

--

Go back
678.0, 334.0
19.0, 19.0

p1

p1

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000019398 MO000022224

MO000041446

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c1 : 1
stoichiometry:c2 : 1
stoichiometry:c3 : 1

m3965*m119368*0.1

nodelay

--

true

0

false

PMID: 18694646,12471095,12539043 TLR3 recognizes double-stranded (ds)RNA and triggers a signaling pathway via a TIR domain-containing adapter inducing IFN-beta (TRIF) (also known as TICAM-1)

Go back
814.0, 598.0
19.0, 19.0

p10

p10

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e26 MO000016573

e35

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c60 : 1
stoichiometry:c96 : 1
stoichiometry:c114 : 1

m29*m1572*0.1

nodelay

--

true

0

false

PMID: 18694646 TLR9 shares the adapter protein MyD88 and the downstream signaling pathway with TLR7.

Go back
438.0, 1242.0
19.0, 19.0

p11

p11

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e14

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c32 : 1
stoichiometry:c33 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 18694646 TRIF associates with TRAF3, TRAF6 and RIP1. TRAF6 and RIP1 activate NF-KappaB and AP-1 while TRAF3 activates TBK1/IKK-i and is followed by a type I IFN response.

Go back
474.0, 1198.0
19.0, 19.0

p11

p12

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e16

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c34 : 1
stoichiometry:c35 : 1

m18*0.1

nodelay

--

true

0

false

PMID: 18694646 TRIF associates with TRAF3, TRAF6 and RIP1. TRAF6 and RIP1 activate NF-KappaB and AP-1 while TRAF3 activates TBK1/IKK-i and is followed by a type I IFN response.

Go back
666.0, 586.0
19.0, 19.0

p4

p13

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e5 MO000019331

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c36 : 1
stoichiometry:c37 : 1
stoichiometry:c38 : 1

m5*m3902*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i).

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651.0, 707.0
17.0, 17.0

p14

p14

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e5 MO000007694

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c39 : 1
stoichiometry:c40 : 1
stoichiometry:c29 : 1

m5*m977*0.1

nodelay

--

true

0

false

--

Go back
890.0, 714.0
19.0, 19.0

p37

p15

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e35 MO000039077 MO000016963 MO000000212 MO000000213 e38 MO000007702

e40

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c115 : 1
stoichiometry:c119 : 1
stoichiometry:c125 : 1
stoichiometry:c126 : 1
stoichiometry:c127 : 1
stoichiometry:c128 : 1
stoichiometry:c129 : 1
stoichiometry:c130 : 1

m38*m17258*m1872*m183*m184*m41*m980*0.1

nodelay

--

true

0

false

PMID: 18694646,16306937,15767370,15361868 Upon exposure to its ligand, MyD88 forms a complex with interleukin-1-receptor (IL-1R)-associated kinase-4 (IRAK-4), IRAK-1, tumor necrosis factor-receptor associated factor 3 (TRAF3), TRAF6, Ikkalpha and IRF-7

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510.0, 1230.0
19.0, 19.0

p11

p16

cso30:i:ME_GeneExpression

cso30:i:CC_NuclearChromosome

--

e20

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c44 : 1
stoichiometry:c45 : 1

m22*0.1

nodelay

--

true

0

false

PMID: 18694646 TRIF associates with TRAF3, TRAF6 and RIP1. TRAF6 and RIP1 activate NF-KappaB and AP-1 while TRAF3 activates TBK1/IKK-i and is followed by a type I IFN response.

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789.0, 385.0
21.0, 21.0

p17

p17

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

MO000041446

e21

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c46 : 1
stoichiometry:c47 : 1

m19314*0.1

nodelay

--

true

0

false

PMID:18694646 Tyrosine phosphorylation of TLR3 induces PI3K recruitment to the receptor and subsequent activation of Akt leads to activation of IRF-3.

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685.0, 745.0
17.0, 17.0

p18

p18

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e21 MO000000030

e22

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c48 : 1
stoichiometry:c49 : 1
stoichiometry:c50 : 1

m23*m27*0.1

nodelay

--

true

0

false

--

Go back
763.0, 707.0
17.0, 17.0

p19

p19

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e22 MO000000048

e23

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c51 : 1
stoichiometry:c52 : 1
stoichiometry:c53 : 1

m24*m45*0.1

nodelay

--

true

0

false

PMID:18694646 Tyrosine phosphorylation of TLR3 induces PI3K recruitment to the receptor and subsequent activation of Akt leads to activation of IRF-3.

Go back
622.0, 398.0
19.0, 19.0

p1

p2

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041125 MO000041446

MO000041437

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c4 : 1
stoichiometry:c5 : 1
stoichiometry:c6 : 1

m18998*m19314*0.1

nodelay

--

true

0

false

PMID: 18694646,12471095,12539043 TLR3 recognizes double-stranded (ds)RNA and triggers a signaling pathway via a TIR domain-containing adapter inducing IFN-beta (TRIF) (also known as TICAM-1)

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731.0, 959.0
17.0, 17.0

p19

p20

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e23 MO000007694

e20

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c54 : 1
stoichiometry:c55 : 1
stoichiometry:c26 : 1

m25*m977*0.1

nodelay

--

true

0

false

PMID:18694646 Tyrosine phosphorylation of TLR3 induces PI3K recruitment to the receptor and subsequent activation of Akt leads to activation of IRF-3.

Go back
282.0, 262.0
19.0, 19.0

p21

p21

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e24 MO000066987

e25

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c57 : 1
stoichiometry:c58 : 1
stoichiometry:c59 : 1

m26*m41844*0.1

nodelay

--

true

0

false

PMID: 18694646,18242112,17038589 RIG-I binds 5prime-triphosphorylated single-stranded (ss)RNA and short dsRNA and stimulates production of type I IFNs

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330.0, 266.0
19.0, 19.0

p21

p22

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000066987 e13

e27

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c61 : 1
stoichiometry:c31 : 1
stoichiometry:c62 : 1

m41844*m15*0.1

nodelay

--

true

0

false

PMID: 18694646,18242112,17038589 RIG-I binds 5prime-triphosphorylated single-stranded (ss)RNA and short dsRNA and stimulates production of type I IFNs

Go back
283.0, 383.0
17.0, 17.0

p23

p23

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e24

e28

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c63 : 1
stoichiometry:c64 : 1
stoichiometry:c65 : 1

m76904*m26*0.1

nodelay

--

true

0

false

PMID: 18694646,16625202 By contrast, MDA5 preferentially recognizes longer-dsRNA, including synthetic poly-IC

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218.0, 482.0
19.0, 19.0

p23

p24

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000103999 e29

e30

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c66 : 1
stoichiometry:c67 : 1
stoichiometry:c68 : 1

m76904*m32*0.1

nodelay

--

true

0

false

PMID: 18694646,16625202 By contrast, MDA5 preferentially recognizes longer-dsRNA, including synthetic poly-IC

Go back
346.0, 406.0
19.0, 19.0

p25

p25

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e25 MO000094908

e31

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c69 : 1
stoichiometry:c70 : 1
stoichiometry:c71 : 1

m28*m68199*0.1

nodelay

--

true

0

false

PMID: 18694646,16127453,16125763,16177806,16153868 Both RIG-I and MDA5 associate with an adapter protein IPS-1 also known as MAVS, VISA or CARDIF, which also contains an N-terminal CARD

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358.0, 494.0
19.0, 19.0

p25

p26

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e28 MO000094908

e32

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c72 : 1
stoichiometry:c184 : 1
stoichiometry:c73 : 1

m31*m68199*0.1

nodelay

--

true

0

false

PMID: 18694646,16127453,16125763,16177806,16153868 Both RIG-I and MDA5 associate with an adapter protein IPS-1 also known as MAVS, VISA or CARDIF, which also contains an N-terminal CARD

Go back
485.0, 469.0
17.0, 17.0

p27

p27

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000016963

e33

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c74 : 1
stoichiometry:c75 : 1
stoichiometry:c76 : 1

m34*m1872*0.1

nodelay

--

true

0

false

PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.

Go back
415.0, 567.0
17.0, 17.0

p27

p28

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000016963 e32

e34

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c77 : 1
stoichiometry:c78 : 1
stoichiometry:c79 : 1

m1872*m35*0.1

nodelay

--

true

0

false

PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.

Go back
539.0, 619.0
17.0, 17.0

p29

p29

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e33 MO000019331

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c80 : 1
stoichiometry:c81 : 1
stoichiometry:c82 : 1

m36*m3902*0.1

nodelay

--

true

0

false

PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.

Go back
587.0, 427.0
17.0, 17.0

p3

p3

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000041437 MO000016963 MO000000212 MO000000065 MO000019241

e5

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c7 : 1
stoichiometry:c8 : 1
stoichiometry:c10 : 1
stoichiometry:c11 : 1
stoichiometry:c12 : 1
stoichiometry:c9 : 1

m19305*m1872*m183*m6*m3825*0.1

nodelay

--

true

0

false

PMID: 18694646,14530355,15064760 TRIF associates with TRAF3 and TRAF6 via TRAF-binding motifs which exist in its N-terminal portion and also with receptor interacting protein (RIP) 1 and RIP3 via RIP homotypic interaction motif (RHIM)

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551.0, 691.0
17.0, 17.0

p29

p30

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e34 MO000019331

e18

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c83 : 1
stoichiometry:c84 : 1
stoichiometry:c85 : 1

m37*m3902*0.1

nodelay

--

true

0

false

PMID: 18694646 IPS-1 then associates with TRAF3, followed by activation of TBK1 and Ikk-i.

Go back
547.0, 767.0
17.0, 17.0

p31

p31

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e18 MO000007694

MO000041456

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c86 : 1
stoichiometry:c87 : 1
stoichiometry:c88 : 1

m20*m977*0.1

nodelay

--

true

0

false

PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production

Go back
831.0, 891.0
17.0, 17.0

p31

p32

cso30:i:ME_Phosphorylation

cso30:i:CC_Cytosol

--

e18 MO000007702

MO000041457

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c89 : 1
stoichiometry:c90 : 1
stoichiometry:c91 : 1

m20*m980*0.1

nodelay

--

true

0

false

PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production

Go back
595.0, 1243.0
17.0, 17.0

p33

p33

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041456

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c92 : 1
stoichiometry:c93 : 1

m19324*0.1

nodelay

--

true

0

false

PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production

Go back
623.0, 1131.0
17.0, 17.0

p33

p34

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

MO000041457

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c94 : 1
stoichiometry:c95 : 1

m19325*0.1

nodelay

--

true

0

false

PMID: 18694646,15210742,15800576 These kinases phosphorylate IRF3 and IRF7 and induce type I IFN production

Go back
888.0, 288.0
23.0, 23.0

p35

p35

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042126 e15

e36

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c97 : 1
stoichiometry:c41 : 1
stoichiometry:c98 : 1

m19940*m17*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1

Go back
981.0, 353.0
21.0, 21.0

p36

p36

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e36 MO000016573

e37

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c99 : 1
stoichiometry:c100 : 1
stoichiometry:c101 : 1

m39*m1572*0.1

nodelay

--

true

0

false

PMID: 18694646 TLR7 signals through a TIR domain-containing adapter, myeloid differentiation factor 88 (MyD88).

Go back
1066.0, 410.0
19.0, 19.0

p37

p37

cso30:i:ME_Binding

cso30:i:CC_EndosomeLumen

--

e37 MO000000213 MO000039077 MO000016963 MO000000212 e38 MO000007702

e39

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c102 : 1
stoichiometry:c103 : 1
stoichiometry:c104 : 1
stoichiometry:c105 : 1
stoichiometry:c106 : 1
stoichiometry:c107 : 1
stoichiometry:c108 : 1
stoichiometry:c109 : 1

m40*m184*m17258*m1872*m183*m41*m980*0.1

nodelay

--

true

0

false

PMID: 18694646,16306937,15767370,15361868 Upon exposure to its ligand, MyD88 forms a complex with interleukin-1-receptor (IL-1R)-associated kinase-4 (IRAK-4), IRAK-1, tumor necrosis factor-receptor associated factor 3 (TRAF3), TRAF6, Ikkalpha and IRF-7

Go back
654.0, 1166.0
19.0, 19.0

p40

p38

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c111 : 1
stoichiometry:c112 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines

Go back
943.0, 927.0
17.0, 17.0

p38

p39

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39

e42 e72

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c113 : 1
stoichiometry:c30 : 1
stoichiometry:c185 : 1

m42*0.1

nodelay

--

true

0

false

PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines PMID: 18694646 Figure 2

Go back
602.0, 510.0
19.0, 19.0

p4

p4

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e5 MO000016574

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c13 : 1
stoichiometry:c14 : 1
stoichiometry:c15 : 1

m5*m1573*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i).

Go back
594.0, 1294.0
19.0, 19.0

p40

p40

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e42

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c124 : 1
stoichiometry:c116 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines

Go back
402.0, 1298.0
19.0, 19.0

p40

p41

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e14

e17

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c117 : 1
stoichiometry:c118 : 1

m16*0.1

nodelay

--

true

0

false

PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines

Go back
734.0, 1190.0
19.0, 19.0

p40

p42

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e42

e41

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c122 : 1
stoichiometry:c123 : 1

m46*0.1

nodelay

--

true

0

false

PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines

Go back
802.0, 550.0
19.0, 19.0

p43

p43

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e39 MO000016574

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c110 : 1
stoichiometry:c120 : 1
stoichiometry:c121 : 1

m42*m1573*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1

Go back
706.0, 894.0
19.0, 19.0

p44

p44

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 MO000016574

e6

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c131 : 1
stoichiometry:c132 : 1
stoichiometry:c133 : 1

m43*m1573*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure2

Go back
1063.0, 851.0
17.0, 17.0

p45

p45

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e40 MO000007685

e43

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c134 : 1
stoichiometry:c135 : 1
stoichiometry:c136 : 1

m43*m970*0.1

nodelay

--

true

0

false

PMID: 18694646,17273999 cDCs and macrophages also respond to CpG-DNA and produce small amounts of IFN-beta through IRF-1 activation rather than IRF-3 or IRF-7 activation

Go back
742.0, 1350.0
19.0, 19.0

p46

p46

cso30:i:ME_GeneExpression

cso30:i:CC_Nucleoplasm

--

e43

G010228

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c137 : 1
stoichiometry:c138 : 1

m47*0.1

nodelay

--

true

0

false

PMID: 18694646,17273999 cDCs and macrophages also respond to CpG-DNA and produce small amounts of IFN-beta through IRF-1 activation rather than IRF-3 or IRF-7 activation

Go back
405.0, 197.0
21.0, 21.0

p47

p47

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000116924 e13

e44

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c139 : 1
stoichiometry:c140 : 1
stoichiometry:c141 : 1

m86033*m15*0.1

nodelay

--

true

0

false

PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)

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245.0, 173.0
19.0, 19.0

p47

p48

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000116924 e24

e45

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c142 : 1
stoichiometry:c143 : 1
stoichiometry:c144 : 1

m86033*m26*0.1

nodelay

--

true

0

false

PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)

Go back
635.0, 247.0
17.0, 17.0

p49

p49

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e44 MO000044014

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c145 : 1
stoichiometry:c146 : 1
stoichiometry:c147 : 1

m48*m21736*0.1

nodelay

--

true

0

false

PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)

Go back
370.0, 906.0
19.0, 19.0

p4

p5

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000210 e6

e11

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c16 : 1
stoichiometry:c18 : 1
stoichiometry:c17 : 1

m181*m11*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i).

Go back
595.0, 199.0
17.0, 17.0

p49

p50

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e45 MO000044014

e46

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c148 : 1
stoichiometry:c149 : 1
stoichiometry:c150 : 1

m49*m21736*0.1

nodelay

--

true

0

false

PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)

Go back
911.0, 243.0
17.0, 17.0

p49

p51

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e46 MO000016828

e47

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c151 : 1
stoichiometry:c152 : 1
stoichiometry:c153 : 1

m63*m1765*0.1

nodelay

--

true

0

false

PMID: 18694646,17008311,16407888 Cryopyrin/NALP3 was shown to recognize both ssRNA and dsRNA of viral origin or their synthetic versions and to induce caspase-1 activation via apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC)

Go back
985.0, 865.0
21.0, 21.0

p52

p52

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e68 e69

MO000042126

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c154 : 1
stoichiometry:c155 : 1
stoichiometry:c156 : 1

m73*m74*0.1

nodelay

--

true

0

false

PMID: 18694646,18305481 Recently endoplasmic reticulum (ER) protein UNC93B1 turned out to be essential for trafficking of TLR7 and TLR9 from ER to endosome,but what triggers this TLR-trafficking from ER to endosome before viral recognition by TLRs remains to be elucidated.

Go back
1101.0, 765.0
21.0, 21.0

p52

p53

cso30:i:ME_Translocation

cso30:i:CC_Cytosol

--

e67 e69

MO000042012

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c157 : 1
stoichiometry:c159 : 1
stoichiometry:c158 : 1

m72*m74*0.1

nodelay

--

true

0

false

PMID: 18694646,18305481 Recently endoplasmic reticulum (ER) protein UNC93B1 turned out to be essential for trafficking of TLR7 and TLR9 from ER to endosome,but what triggers this TLR-trafficking from ER to endosome before viral recognition by TLRs remains to be elucidated.

Go back
234.0, 574.0
19.0, 19.0

p54

p54

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e32 MO000016899

e70

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c160 : 1
stoichiometry:c161 : 1
stoichiometry:c162 : 1

m35*m1814*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
302.0, 534.0
19.0, 19.0

p54

p55

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

e31 MO000016899

e71

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c163 : 1
stoichiometry:c164 : 1
stoichiometry:c165 : 1

m34*m1814*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
238.0, 682.0
19.0, 19.0

p56

p56

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e70 MO000017669

MO000016900

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c166 : 1
stoichiometry:c167 : 1
stoichiometry:c168 : 1

m75*m2432*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
318.0, 738.0
19.0, 19.0

p56

p57

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e71 MO000017669

MO000016900

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c169 : 1
stoichiometry:c170 : 1
stoichiometry:c171 : 1

m76*m2432*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
370.0, 810.0
19.0, 19.0

p56

p58

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e71 MO000018276

MO000016906

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c172 : 1
stoichiometry:c173 : 1
stoichiometry:c174 : 1

m76*m2932*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
274.0, 814.0
19.0, 19.0

p56

p59

cso30:i:ME_Cleavage

cso30:i:CC_Cytosol

--

e70 MO000018276

MO000016906

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c175 : 1
stoichiometry:c176 : 1
stoichiometry:c177 : 1

m75*m2932*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
486.0, 694.0
19.0, 19.0

p4

p6

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e6 e12

MO000000077

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c19 : 1
stoichiometry:c20 : 1
stoichiometry:c21 : 1

m11*m13*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i). PMID: 18694646 Figure 2

Go back
294.0, 1010.0
19.0, 19.0

p60

p60

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016900 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c178 : 1
stoichiometry:c179 : 1
stoichiometry:c180 : 1

m1815*m14*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
338.0, 1018.0
19.0, 19.0

p60

p61

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000016906 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c181 : 1
stoichiometry:c182 : 1
stoichiometry:c183 : 1

m1821*m14*0.1

nodelay

--

true

0

false

PMID: 18694646,16585540 IPS-1 also interacts with Fas-associated death domain-containing protein (FADD) and leads to activation of NF-KappaB through cleavage of caspase-8/-10

Go back
414.0, 1062.0
19.0, 19.0

p4

p7

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

e11 MO000000058

e14

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c22 : 1
stoichiometry:c23 : 1
stoichiometry:c24 : 1

m12*m14*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i). PMID: 18694646 Following the formation of this signaling complex, IRF7 and nuclear factor-kappa B (NF-¦ÊB) are activated, which results in the production of type I IFNs and cytokines PMID: 18694646 Figure 2

Go back
491.0, 927.0
18.0, 18.0

p4

p8

cso30:i:ME_UnknownActivation

cso30:i:CC_Cytosol

--

MO000000077 MO000000276

e16

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c27 : 1
stoichiometry:c28 : 1
stoichiometry:c25 : 1

m69*m219*0.1

nodelay

--

true

0

false

PMID: 18694646 Figure 1 PMID: 18694646 TRAF6 and RIP1 activate NF-KappaB while TRAF3 activates TRAF family member-associated NK-KappaB activator (TANK)-binding kinase 1 (TBK1) and inducible IKappaB kinase (IKK-i) PMID: 18694646 Figure 2.

Go back
1013.0, 609.0
21.0, 21.0

p9

p9

cso30:i:ME_Binding

cso30:i:CC_Cytosol

--

MO000042012 e19

e26

true true true true

--

and

mass

coefficient1:0.1
coefficient2:1.0
stoichiometry:c42 : 1
stoichiometry:c43 : 1
stoichiometry:c56 : 1

m19828*m21*0.1

nodelay

--

true

0

false

PMID: 18694646 TLR9 recognizes unmethylated DNA with a CpG motif (CpG-DNA) and DNA viruses, including herpes simplex virus (HSV)-1, HSV-2 and cytomegalovirus (CMV) in pDCs.

Go back
705.0, 344.0

c1

c1

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
542.0, 354.0

c10

c10

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.946105112698, 349.0

c100

c100

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
946.660151531424, 374.0

c101

c101

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
942.0, 423.5201752525269

c102

c102

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1009.0, 305.0

c103

c103

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1079.5977236172805, 436.83883149728223

c104

c104

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
562.0, 421.60146745051287

c105

c105

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.0, 345.0

c106

c106

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1045.0, 436.9731141883335

c107

c107

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
892.0, 436.52919187348607

c108

c108

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
926.9955171436355, 426.0

c109

c109

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
566.0, 305.0

c11

c11

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
828.2228841505914, 516.0

c110

c110

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
308.0, 1141.0

c111

c111

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
635.279407441456, 1185.0

c112

c112

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
913.0, 525.0

c113

c113

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
831.0, 617.0

c114

c114

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
883.0, 689.0

c115

c115

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
502.22830599112564, 1312.0

c116

c116

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
304.0, 1152.0

c117

c117

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
418.0, 1317.0

c118

c118

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
915.8411065005789, 602.0

c119

c119

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.0, 409.0

c12

c12

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 533.0

c120

c120

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.87772838085, 562.0

c121

c121

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
754.0145352162576, 1059.0

c122

c122

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
644.2752260829116, 1209.0

c123

c123

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
618.316489420069, 1059.0

c124

c124

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
562.0, 468.0

c125

c125

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
546.0, 354.0

c126

c126

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
903.900023141829, 305.0

c127

c127

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
916.003804098719, 732.8660998624929

c128

c128

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
889.0, 740.987927382856

c129

c129

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
628.23995138211, 527.4033959488552

c13

c13

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
862.196065268608, 729.0

c130

c130

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
730.1758195855608, 762.0

c131

c131

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
546.0, 544.0

c132

c132

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.85338655480155, 634.3596099683606

c133

c133

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
855.0, 756.0

c134

c134

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
1017.0, 875.208997614072

c135

c135

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
915.8056398354918, 868.0

c136

c136

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
759.2405150182823, 1034.0

c137

c137

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
711.1008793404288, 1369.0

c138

c138

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.8446454055274, 186.0

c139

c139

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
552.0, 523.2639240088533

c14

c14

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.5037553862376, 225.19191895069815

c140

c140

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
426.0, 211.0

c141

c141

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
271.9999417289742, 183.03053412873655

c142

c142

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.0, 199.73364182289208

c143

c143

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
264.0, 188.0

c144

c144

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
579.0, 256.0

c145

c145

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
657.4897634151657, 194.0

c146

c146

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
652.0, 219.8669836198026

c147

c147

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
351.0, 209.58856459798452

c148

c148

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
619.8094964814716, 186.0

c149

c149

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
514.1564935530408, 528.0

c15

c15

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
612.0, 208.0

c150

c150

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
822.0, 219.0

c151

c151

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
925.6625609418811, 209.0

c152

c152

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
928.0, 252.0

c153

c153

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
931.0, 893.7436835838358

c154

c154

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
981.0, 893.9900187110228

c155

c155

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
845.2251850032362, 354.6843055445091

c156

c156

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
1053.0, 793.8953896122451

c157

c157

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
941.4891031632251, 594.8197720284795

c158

c158

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
983.0, 793.6303891655838

c159

c159

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
295.0, 916.0

c16

c16

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
261.0, 584.0

c160

c160

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.0, 600.9883381862201

c161

c161

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
252.0, 593.0

c162

c162

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
328.2876334417754, 492.0

c163

c163

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
247.0, 559.3900277413852

c164

c164

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
316.0, 553.0

c165

c165

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
264.9880172185127, 688.0

c166

c166

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
214.0, 707.8335884449156

c167

c167

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
241.43970131829198, 701.0

c168

c168

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.89546304620546, 738.0

c169

c169

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
381.0, 925.0

c17

c17

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
217.0, 749.4744111479364

c170

c170

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
256.1754418849364, 756.0

c171

c171

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
383.4906692092933, 752.0

c172

c172

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
342.0, 801.0

c173

c173

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
347.20633098764773, 829.0

c174

c174

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
291.029062765764, 704.0

c175

c175

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
299.90158376078125, 802.0

c176

c176

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
292.0, 833.0

c177

c177

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
243.0, 830.0

c178

c178

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
260.0, 1031.6134655807894

c179

c179

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
386.87363220510133, 628.0

c18

c18

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
297.4839604832151, 1029.0

c180

c180

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
333.0, 888.0

c181

c181

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
260.0, 1033.4417494565182

c182

c182

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
305.352465419694, 1037.0

c183

c183

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
373.5298221281347, 407.0

c184

c184

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
952.0, 560.9935734817245

c185

c185

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
496.0, 628.0

c19

c19

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
688.1167758783465, 60.0

c2

c2

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
440.0, 720.6123554101047

c20

c20

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
497.0, 713.0

c21

c21

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
393.0, 1011.0

c22

c22

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
260.0, 1061.0

c23

c23

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
315.045902066714, 1077.0

c24

c24

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0, 945.0

c25

c25

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
672.364654255002, 972.0

c26

c26

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
504.0698886817927, 871.0

c27

c27

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
459.0, 951.3829385913779

c28

c28

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
656.1185055145116, 724.0

c29

c29

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
695.0, 353.0

c3

c3

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
848.829021351216, 944.0

c30

c30

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
356.9924492668405, 273.0

c31

c31

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
308.0, 1149.0

c32

c32

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
450.0, 1261.0

c33

c33

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
489.32005916226296, 1033.0

c34

c34

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
480.18385947015844, 1217.0

c35

c35

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
692.8870925171259, 586.0

c36

c36

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
618.0, 596.0

c37

c37

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
651.5777087639997, 605.0

c38

c38

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
670.4376015698018, 599.0

c39

c39

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
629.0, 337.0

c4

c4

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
612.0, 731.4323409345194

c40

c40

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
822.0, 271.0

c41

c41

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
937.0, 584.0

c42

c42

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
1032.376236641263, 637.2526564886388

c43

c43

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
529.9931695356361, 1013.0

c44

c44

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
484.91453271171616, 1249.0

c45

c45

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
751.0, 399.64808384839876

c46

c46

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
804.0, 406.0

c47

c47

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
701.2817896360216, 476.0

c48

c48

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
699.3861999450876, 769.6358398242802

c49

c49

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
649.0, 408.0

c5

c5

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
702.0, 649.0279295380494

c50

c50

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
777.5298221281347, 644.0

c51

c51

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
782.8705502811124, 730.3464746087222

c52

c52

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
774.0, 724.0

c53

c53

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
746.9289944709163, 837.0

c54

c54

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
618.0, 857.0

c55

c55

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
909.9677313947838, 609.7178136391697

c56

c56

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
244.0, 272.0

c57

c57

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
235.0, 287.6696984118505

c58

c58

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
296.0, 281.0

c59

c59

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
641.0, 413.0

c6

c6

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
841.0, 608.0

c60

c60

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.0, 289.09505157597033

c61

c61

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
349.0, 282.0

c62

c62

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
292.0, 408.0

c63

c63

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
238.0, 284.0

c64

c64

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
299.0, 400.0

c65

c65

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
245.0, 492.0

c66

c66

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
222.0, 441.0

c67

c67

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
228.0, 501.0

c68

c68

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
344.0, 385.0

c69

c69

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
611.7685735448305, 439.9103049700403

c7

c7

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
372.4460119475228, 401.0

c70

c70

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
365.0, 424.0

c71

c71

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
342.0, 456.0

c72

c72

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
368.0, 513.0

c73

c73

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
446.0, 481.21645747403153

c74

c74

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
509.6082725498476, 463.0

c75

c75

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
495.0, 486.0

c76

c76

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
437.91952058716754, 469.0

c77

c77

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
378.0, 578.0713431680111

c78

c78

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
424.0, 584.0

c79

c79

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
562.0, 444.9088269514547

c8

c8

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
515.0, 567.0

c80

c80

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
562.9329796549933, 604.0

c81

c81

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
556.0, 631.0

c82

c82

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
433.0, 648.0

c83

c83

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
567.0963115579191, 610.0

c84

c84

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
568.0, 676.9935522735371

c85

c85

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
567.9063767279423, 682.0

c86

c86

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
566.6615021863596, 790.50156883887

c87

c87

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
557.0, 784.0

c88

c88

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
652.0, 682.0

c89

c89

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
604.0, 444.0

c9

c9

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
853.8551517954508, 912.4513482233507

c90

c90

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
811.2926937794119, 908.0

c91

c91

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
569.0, 966.0

c92

c92

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
496.0322200240302, 1260.0

c93

c93

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
645.8433924487405, 989.0

c94

c94

cso30:c:InputAssociation

--

true true true true

cso30:c:InputAssociation

threshold

--

0

1,

--

Go back
490.993663049907, 1148.0

c95

c95

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
839.112702690078, 356.0

c96

c96

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
851.0, 311.0886031430172

c97

c97

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back
900.0, 311.0

c98

c98

cso30:c:OutputProcess

--

true true true true

cso30:c:OutputProcess

threshold

--

0

1,

--

Go back
909.0, 367.31519189844283

c99

c99

cso30:c:InputProcess

--

true true true true

cso30:c:InputProcess

threshold

--

0

1,

--

Go back